Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases

ABSTRACT

Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a U.S. National Stage Application under 35 U.S.C. § 371 of International Patent Application No. PCT/US2016/068697, filed on Dec. 27, 2016, which claims priority to U.S. Provisional Patent Application No. 62/271,864, filed Dec. 28, 2015, the entireties of which are incorporated by reference.

1. FIELD

Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY

This application incorporates by reference a Substitute Sequence Listing submitted as a text file entitled “12827-980-999_SEQ_LISTING.txt” created on Feb. 11, 2020 and having a size of 17,948 bytes.

2. BACKGROUND 2.1 Cereblon

At least two isoforms of the protein cereblon (CRBN) exist, which are 442 and 441 amino acids long, respectively, and CRBN is conserved from plant to human. In humans, the CRBN gene has been identified as a candidate gene of an autosomal recessive nonsyndromic mental retardation (ARNSMR). See Higgins, J. J. et al., Neurology, 2004, 63:1927-1931. CRBN was initially characterized as an RGS-containing novel protein that interacted with a calcium-activated potassium channel protein (SLO1) in the rat brain, and was later shown to interact with a voltage-gated chloride channel (CIC-2) in the retina with AMPK1 and DDB1. See Jo, S. et al., J. Neurochem, 2005, 94:1212-1224; Hohberger B. et al., FEBS Lett, 2009, 583:633-637; Angers S. et al., Nature, 2006, 443:590-593. DDB1 was originally identified as a nucleotide excision repair protein that associates with damaged DNA binding protein 2 (DDB2). Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). DDB1 also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CRBN has also been identified as a target for the development of therapeutic agents for diseases of the cerebral cortex. See WO 2010/137547 A1.

CRBN has recently been identified as a key molecular target that binds to thalidomide to cause birth defects. See Ito, T. et al., Science, 2010, 327:1345-1350. DDB1 was found to interact with CRBN and, thus, was indirectly associated with thalidomide. Moreover, thalidomide was able to inhibit auto-ubiquitination of CRBN in vitro, suggesting that thalidomide is an E3 ubiquitin-ligase inhibitor. Id. Importantly, this activity was inhibited by thalidomide in wild-type cells, but not in cells with mutated CRBN binding sites that prevent thalidomide binding. Id. The thalidomide binding site was mapped to a highly conserved C-terminal 104 amino acid region in CRBN. Id. Individual point mutants in CRBN, Y384A and W386A were both defective for thalidomide binding, with the double point mutant having the lowest thalidomide-binding activity. Id. A link between CRBN and the teratogenic effect of thalidomide was confirmed in animal models of zebra-fish and chick embryos. Id.

Whether binding to CRBN, the CRBN E3 ubiquitin-ligase complex, or one or more substrates of CRBN, is required for the beneficial effects of thalidomide and other drugs is yet to be established. Understanding these interactions with thalidomide and other drug targets will allow the definition of the molecular mechanisms of efficacy and/or toxicity and may lead to drugs with improved efficacy and toxicity profiles.

2.2 Compounds

Compounds for the methods provided herein comprises a group of immunomodulatory compounds, including but not limited to, thalidomide, lenalidomide and pomalidomide which have shown remarkable responses in patients with multiple myeloma, lymphoma and other hematological diseases such as myelodysplastic syndrome. See Galustian C, et al., Expert Opin Pharmacother., 2009, 10:125-133. These drugs display a broad spectrum of activity, including anti-angiogenic properties, modulation of pro-inflammatory cytokines, co-stimulation of T cells, increased NK cell toxicity, direct anti-tumor effects and modulation of stem cell differentiation. For example, thalidomide and lenalidomide have emerged as important options for the treatment of multiple myeloma in newly diagnosed patients, in patients with advanced disease who have failed chemotherapy or transplantation, and in patients with relapsed or refractory multiple myeloma. Lenalidomide in combination with dexamethasone has been approved for the treatment of patients with multiple myeloma who have received at least one prior therapy. Pomalidomide may also be administered in combination with dexamethasone. U.S. Patent Publication No. 2004/0029832 A1, the disclosure of which is hereby incorporated in its entirety, discloses the treatment of multiple myeloma.

Other exemplary compounds provided herein include 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (“Compound A”), 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (“Compound B”), and 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea (“Compound C”), or an enantiomer or a mixture of enantiomers thereof or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Understanding the interactions of CRBN, the CRBN E3 ubiquitin-ligase complex, or one or more substrates of CRBN with thalidomide, lenalidomide, pomalidomide and other drug targets will allow the definition of the molecular mechanisms of efficacy and/or toxicity and may lead to drugs with improved efficacy and toxicity profiles.

3. SUMMARY

We have discovered that CRBN has pluripotent potential as a drug target for the treatment of various diseases. We believe we are the first to report and understand that cereblon can be induced to undergo conformational changes by use of certain small molecules or other agents that we will call “cereblon modifying agents” (CMAs). The use of the appropriate agent leads to a distinct conformational change or other alteration in the properties of the CRBN surface, and a resulting distinct phenotypic response. Cereblon is not simply a unidimensional or monotypic protein that interacts with a single substrate. Instead, without being limited by theory, the conformational change or phenotypic response of cereblon or its pathway is dependent upon cell type and, most importantly, the CMA used to interact with cereblon or its pathway.

As such, we describe herein a variety of distinct conformational changes, surface property alterations, phenotypic responses and CMAs. We also describe treatment methods, compositions, drug screens and computational methods that exploit these discoveries.

We also describe the use of known agents as CMAs for new treatment methods. In another embodiment we disclose the use of new CMA or CMA classes based upon the conformational change, alteration in surface properties, or phenotypic response. It should be noted that these discoveries permit a plethora of methods to be used to treat diseases associated with cereblon pathway. Thus, also described herein are known or new agents as CMAs for use in methods for treating diseases.

In one aspect, provided herein is a method of identifying a test compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface. In certain embodiments, the method comprises (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound that induces a CRBN conformational change or otherwise alters the properties of a CRBN surface. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein.

In certain embodiments of the various compositions and methods provided herein, the properties of the CRBN surface are altered by the placement of compound appendages.

In a second aspect, provided herein is a method of identifying a test compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface. In certain embodiments, the method comprises (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or otherwise alters the properties of a CRBN surface. In some embodiments, the first three-dimensional structure is of a CRBN that is not bound to a reference compound (also sometimes referred to as an “unbound CRBN” herein, and which is not meant to preclude the CRBN being bound to other proteins, e.g., DDB1). In some embodiments, the CRBN that is not bound to a reference compound (or unbound CRBN) has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of an unbound CRBN, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In some embodiments, the first crystal structure of the unbound CRBN has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of an unbound CRBN; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In some embodiments of the various compositions and methods provided herein, the crystal structure of CRBN is a crystal structure of mouse CRBN. In some embodiments, the crystal structure of CRBN is a crystal structure of mouse CRBN that is bound to a reference compound. In other embodiments, the crystal structure of CRBN is a crystal structure of mouse CRBN that is not bound to a reference compound. In one embodiment, the crystal structure of mouse CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In certain embodiments of the various compositions and methods provided herein, the crystal structure of CRBN is a crystal structure of human CRBN. In some embodiments, the crystal structure of CRBN is a crystal structure of human CRBN that is bound to a reference compound. In other embodiments, the crystal structure of CRBN is a crystal structure of human CRBN that is not bound to a reference compound. In certain embodiments, the CRBN is further bound to DDB1. In other embodiments of the various compositions and methods provided herein, the CMA-binding pocket of CRBN is an immunomodulatory agent-binding pocket.

In a third aspect, provided herein is a method of identifying a test compound that has a specific downstream biological activity comprising: (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound has the specific downstream biological activity. In some embodiments, the first crystal structure is of a CRBN that is not bound to a reference compound. In one embodiment, the crystal structure of mouse CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. In some embodiments, the method further comprises assaying the specific biological activity. Also provided herein is a test compound identified by this method. In some embodiments, the compound induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In certain embodiments, the method further comprises administering said compound to a patient, wherein said biological activity is modulated in said patient. In certain embodiments, the patient has a disease, and wherein one or more symptoms of said disease are alleviated following said administration.

In a fourth aspect, provided herein is a method of identifying a test compound that has a specific downstream biological activity comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound has the specific downstream biological activity. In some embodiments, the first three-dimensional structure is of a CRBN that is not bound to a reference compound. In one embodiment, the crystal structure of mouse CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments of the various methods provided herein, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In certain embodiments, the CRBN is further bound to DDB1.

In some embodiments of the various compositions and methods provided herein, the CRBN is a mouse CRBN. In certain embodiments of the various compositions and methods provided herein, CRBN is a human CRBN. In some embodiments, the CRBN is further bound to DDB1. In other embodiments of the various compositions and methods provided herein, the CMA-binding pocket of CRBN is an immunomodulatory agent-binding pocket.

In a fifth aspect, provided herein is a method of identifying a test compound that has a specific therapeutic efficacy comprising: (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound has the specific therapeutic efficacy. In some embodiments, the first crystal structure is of a CRBN that is not bound to a reference compound. In one embodiment, the first crystal structure of CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In certain embodiments, the method further comprises administering said compound to a patient having disease, disorder or condition, wherein one or more symptoms of said disease, disorder or condition is alleviated following said administration. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In certain embodiments, the CRBN is further bound to DDB1.

In a sixth aspect, provided herein is a method of identifying a test compound that has a specific downstream biological activity comprising: (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound has the specific downstream biological activity. In some embodiments, the first three-dimensional structure is of a CRBN that is not bound to a reference compound. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a seventh aspect, provided herein is a method of designing a test compound based on fit within CMA binding pocket of CRBN, comprising: (a) generating on a computer, three-dimensional structural features of a CRBN having a conformational change in the CMA binding pocket, (b) designing a test compound capable of selectively binding to said CMA binding pocket, (c) synthesizing said test compound, (d) contacting CRBN with said synthesized test compound, and (e) determining if said test compound binds to said CRBN. In certain embodiments, the conformational change occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change is relative to a CRBN that is not bound to a reference compound. In other embodiments, the conformational change is relative to a CRBN that is bound to a reference compound.

In an eighth aspect, provided herein is a crystal of a complex comprising CRBN and a CMA, or an analog thereof. Also provided herein is a method of obtaining the crystal, comprising concentrating a purified complex of the CRBN and the CMA, or analog thereof, and obtaining the crystal. In certain embodiments, provided herein is a crystal comprising CRBN. In some embodiments, provided herein is a crystal consisting of CRBN. In certain embodiments, provided herein is a crystal of a complex comprising CRBN and DDB1. In some embodiments, provided herein is a crystal of a complex consisting of CRBN and DDB1. In certain embodiments, provided herein is a crystal of a complex comprising CRBN and a CMA, or an analog thereof. In some embodiments, provided herein is a crystal of a complex consisting of CRBN and a CMA or an analog thereof. In certain embodiments, provided herein is a crystal of a complex comprising CRBN, DDB1, and a CMA, or an analog thereof. In some embodiments, provided herein is a crystal of a complex consisting of CRBN, DDB1, and a CMA or an analog thereof. Methods of obtaining such crystals are also provided herein.

In certain embodiments, the CRBN is bound to DDB1. In some embodiments, the CRBN is bound to Cul4. In other embodiments, the CRBN is bound to Roc1. In some embodiments, the CRBN is bound to DDB1 and Cul4. In other embodiments, the CRBN is bound to DDB1 and Roc1. In yet other embodiments, the CRBN is bound to Cul4 and Roc1. In some embodiments, the CRBN is bound to DDB1, Cul4 and Roc1. In certain embodiments, CRBN that is bound to DDB1, Cul4 and/or Roc1 is a complex with DDB1, Cul4 and/or Roc1, respectively. Crystals comprising CRBN and DDB1, Cul4 and/or Roc1 are also contemplated, as are methods of obtaining such crystals.

In certain embodiments, the CMA is thalidomide. In other embodiments, the CMA is pomalidomide. In some embodiments, the CMA is Compound B. In other embodiments, the CMA is 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea (Compound C). In certain embodiments, the CMA is a thalidomide analog. In other embodiments, the CMA is a pomalidomide analog. In some embodiments, the CMA is a Compound B analog. In other embodiments, the CMA is a Compound C analog. In other embodiments, the CMA is not thalidomide. In other embodiments, the CMA is not pomalidomide. In some embodiments, the CMA is not Compound B. In other embodiments, the CMA is not Compound C. In other embodiments, the CMA is not a thalidomide analog. In other embodiments, the CMA is not a pomalidomide analog. In some embodiments, the CMA is not a Compound B analog. In other embodiments, the CMA is not a Compound C analog.

In a ninth aspect, provided herein is a crystal of a complex comprising CRBN and a test compound, wherein said crystal has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in any one of Tables 3, 4, 5, 6 or 7. In one embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 3. In another embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 4. In other embodiments, the crystal has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 5. In other embodiments, the crystal has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 6. In other embodiments, the complex has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 7. In some embodiments, the crystal further comprises DDB1, Cul4 and/or Roc1. In a specific embodiment, the complex further comprises DDB1.

In a tenth aspect, provided herein is a crystal of a complex comprising a CRBN and a test compound, wherein said crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in any one of Tables 3, 4, 5, 6 or 7. In one embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in Table 3. In another embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in Table 4. In yet another embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in Table 5. In yet another embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in Table 6. In some embodiments, the crystal further comprises DDB1, Cul4 and/or Roc1. In a specific embodiment, the crystal further comprises DDB1. In yet another embodiment, the crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has the atomic coordinates set forth in Table 7. In some embodiments, the complex further comprises DDB1, Cul4 and/or Roc1. In a specific embodiment, the complex further comprises DDB1.

In certain embodiments of the methods provided herein a complex comprising CRBN and reference compound has a three-dimensional structure as determined by x-ray diffraction, having the atomic coordinates set forth in any one of Tables 3, 4, 5, 6 or 7. In one embodiment, the three-dimensional structure has the atomic coordinates set forth in Table 3. In another embodiment, the three-dimensional structure has the atomic coordinates set forth in Table 4. In yet another embodiment, the three-dimensional structure has the atomic coordinates set forth in Table 5. In yet another embodiment, the three-dimensional structure has the atomic coordinates set forth in Table 6. In yet another embodiment, the three-dimensional structure has the atomic coordinates set forth in Table 7. In some embodiments, the complex further comprises DDB1, Cul4 and/or Roc1. In a specific embodiment, the complex further comprises DDB1.

In an eleventh aspect, provided herein is a method of identifying a test compound that induces a specific biological activity, comprising contacting the test compound with CRBN, inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface, and assessing conformational change or alteration wherein conformational change or alteration is indicative of a specific biological activity. In some embodiments, the method further comprises assaying the specific biological activity. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound induces a CRBN conformational change relative to a CRBN contacted with a reference compound. In some embodiments, the test compound induces a CRBN conformational change relative to a CRBN bound to a reference compound. In other embodiments, the test compound induces a CRBN conformational change relative to a CRBN that is not contacted with a reference compound. In one embodiment, the CRBN that is not contacted with a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the test compound induces a CRBN conformational change relative to an unbound CRBN. In other embodiments, the test compound alters the properties of the CRBN surface. In some embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN contacted with a reference compound. In other embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN bound to a reference compound. In some embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN that is not contacted with a reference compound. In other embodiments, the test compound alters the properties of the CRBN surface relative to an unbound CRBN. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In certain embodiments, the method further comprises administering said compound to a patient, wherein said biological activity is modulated in said patient. In certain embodiments, the patient has a disease, and wherein one or more symptoms of said disease are alleviated following said administration. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In some embodiments, the first crystal structure is of a CRBN that is not bound to a reference compound. In one embodiment, the first crystal structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In other embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a twelfth aspect, provided herein is a method of identifying a test compound that has a specific therapeutic utility, comprising contacting the test compound with CRBN, inducing a CRBN conformational change or otherwise altering the properties of the CRBN surface, and assessing the conformational change or alteration, wherein a conformational change or alteration is indicative of the specific therapeutic utility. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound induces a CRBN conformational change relative to a CRBN contacted with a reference compound. In some embodiments, the test compound induces a CRBN conformational change relative to a CRBN bound to a reference compound. In other embodiments, the test compound induces a CRBN conformational change relative to a CRBN that is not contacted with a reference compound. In some embodiments, the test compound induces a CRBN conformational change relative to an unbound CRBN. In other embodiments, the test compound alters the properties of the CRBN surface. In some embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN contacted with a reference compound. In other embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN bound to a reference compound. In some embodiments, the test compound alters the properties of the CRBN surface relative to a CRBN that is not contacted with a reference compound. In other embodiments, the test compound alters the properties of the CRBN surface relative to an unbound CRBN. In one embodiment, the structure of the unbound CRBN has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In some embodiments, the method further comprises administering said compound to a patient having a disease, wherein one or more symptoms of said disease is alleviated following said administration. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is bound to DDB1.

In a thirteenth aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a compound, wherein said CRBN conformational change or alteration results in a specific biological activity. In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In one embodiment, the CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In some embodiments, the biological activity is a tumoricidal effect. In other embodiments, the biological activity is an apoptosis effect. In some embodiments, the biological activity is anti-proliferation. In yet other embodiments, the biological activity is PBMC viability. In some embodiments, the biological activity is toxicity. In certain embodiments, the biological activity is substrate degradation. In one embodiments, the biological activity is Aiolos degradation. In another embodiments, the biological activity is Ikaros degradation. In other embodiments, the biological activity is an immune-mediated effect. In another embodiment, the biological activity is IL-2 induction. In some embodiments, the biological activity is IL-2 repression. In yet other embodiments, the biological activity is an effect on fetal hemoglobin (HbF). Any combination of one, two, three or more of the aforementioned biological activities is also contemplated. In certain embodiments, the biological activity is based on specific cell type categories. In other embodiments, the biological activity is based on specific tissue type categories. In yet other embodiments, the biological activity is based on solid tumors or solid tumor categories. In some embodiments, the biological activity is based on non-solid tumor categories. In some embodiments, a CRBN conformational change is induced. In other embodiments, and alteration in the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In other embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a fourteenth aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a compound, wherein said CRBN conformational change or alteration results in a specific therapeutic utility. In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In some embodiments, the unbound CRBN or the CRBN prior to contact with the test compound has a three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the therapeutic utility is based on solid tumors or solid tumor categories. In other embodiments, the therapeutic utility is based on non-solid tumor categories. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a fifteenth aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a test compound, wherein said CRBN conformational change or alteration results in a different substrate specificity as compared to the substrate specificity of a CRBN that is contacted with a reference compound. Also provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a test compound, wherein said CRBN conformational change or alteration results in a different substrate specificity as compared to the substrate specificity of an unbound CRBN (e.g., a CRBN prior to contact with the test compound). In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In some embodiments, the unbound CRBN or the CRBN prior to contact with the test compound has a three-dimensional structure as determined by x-ray diffraction having atomic coordinates set forth in Table 8. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a sixteenth aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a test compound. In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In one embodiment, the unbound CRBN or the CRBN prior to contact with the test compound has a first three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, said CRBN conformational change or alteration comprises a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) that is different than the conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) contacted with a reference compound. In some embodiments, the CRBN conformational change or alteration results in a different biological activity. In some embodiments, the CRBN conformational change or alteration results in a different therapeutic utility. In other embodiments, the CRBN conformational change or alteration results in a different substrate specificity. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a seventeenth aspect, provided herein is a method of inducing a biological activity in a cell comprising CRBN, comprising contacting said cell with a test compound, wherein said compound induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) of said CRBN, and wherein said CRBN conformational change or alteration is as compared to a reference compound, and wherein the conformational change or alteration results in said biological activity. Also provided herein is a method of inducing a biological activity in a cell comprising CRBN, comprising contacting said cell with a test compound, wherein said compound induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) of said CRBN, and wherein said CRBN conformational change or alteration is as compared to an unbound CRBN (e.g., a CRBN prior to contact with the test compound), and wherein the conformational change or alteration results in said biological activity. In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In one embodiment, the unbound CRBN or the CRBN prior to contact with the test compound has a first three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In some embodiments, the biological activity is a tumoricidal effect. In other embodiments, the biological activity is an apoptosis effect. In some embodiments, the biological activity is anti-proliferation. In yet other embodiments, the biological activity is PBMC viability. In some embodiments, the biological activity is toxicity. In certain embodiments, the biological activity is substrate degradation. In one embodiments, the biological activity is Aiolos degradation. In another embodiments, the biological activity is Ikaros degradation. In other embodiments, the biological activity is an immune-mediated effect. In another embodiment, the biological activity is IL-2 induction. In some embodiments, the biological activity is IL-2 repression. In yet other embodiments, the biological activity is a HbF effect. Any combination of one, two, three or more of the aforementioned biological activities is also contemplated. In certain embodiments, the biological activity is based on specific cell type categories. In other embodiments, the biological activity is based on specific tissue type categories. In yet other embodiments, the biological activity is based on solid tumors or solid tumor categories. In some embodiments, the biological activity is based on non-solid tumor categories. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the unbound CRBN or the CRBN prior to contact with the test compound has a first three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In an eighteenth aspect, provided herein is a method of treating or alleviating one or more symptoms of a CRBN-mediated disease or disorder in a patient, comprising administering a test compound to the subject, wherein said test compound induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), and wherein said CRBN conformational change or alteration is as compared to a reference compound, and wherein said CRBN conformational change or alteration results in treatment or alleviation of one or more symptoms of said disease or disorder. Also provided herein is a method of treating or alleviating one or more symptoms of a CRBN-mediated disease or disorder in a patient, comprising administering a test compound to the subject, wherein said test compound induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), and wherein said CRBN conformational change or alteration is as compared to an unbound CRBN (e.g., a CRBN prior to contact with the test compound), and wherein said CRBN conformational change or alteration results in treatment or alleviation of one or more symptoms of said disease or disorder. In one embodiment, the method induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In one embodiment, the CRBN conformational change is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the CRBN conformational change is relative to an unbound CRBN. In a specific embodiment, the CRBN conformational change is relative to the CRBN prior to contact with the test compound. In one embodiment, the unbound CRBN or the CRBN prior to contact with the test compound has a first three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In another embodiment, the method induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In one embodiment, the alteration of the properties of the CRBN surface is relative to a CRBN that is bound to a reference compound. In a certain embodiment, the alteration of the properties of the CRBN surface is relative to an unbound CRBN. In a specific embodiment, the alteration of the properties of the CRBN surface is relative to the CRBN prior to contact with the test compound. In certain embodiments, the disease or disorder is a cancer or tumor. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first crystal structure of CRBN has a first three-dimensional structure as determined by x-ray diffraction having the atomic coordinates set forth in Table 8. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1. In some embodiments provided herein is the above-described test compound for use in a method of treating or alleviating one or more symptoms of a CRBN-mediated disease or disorder in a patient.

In a nineteenth aspect, provided herein is a composition comprising a CRBN and a test compound, wherein said CRBN has a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) as compared to a reference compound. Also provided herein is a composition comprising a CRBN and a test compound, wherein said CRBN has a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) as compared to an unbound CRBN (e.g., a CRBN prior to contact with the test compound). In one embodiment, the CRBN has a conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In another embodiment, the CRBN has an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN as determined by x-ray diffraction has atomic coordinates set forth in Table 8. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a twentieth aspect, provided herein is a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) upon contact with said CRBN, as compared to the conformational change or alteration as compared to a reference compound. Also provided herein is a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) upon contact with said CRBN, as compared to the conformational change or alteration as compared to an unbound CRBN (e.g., prior to contact with the compound). In one embodiment, the unbound CRBN has a three-dimensional structure as determined by x-ray diffraction having atomic coordinates set forth in Table 8. In one embodiment, the compound induces a CRBN conformational change. In a specific embodiment, the CRBN conformational change is within the CMA-binding pocket of the CRBN. In another embodiment, the compound induces an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In some embodiments, the CRBN conformational change or alteration results in a different biological activity. In some embodiments, the CRBN conformational change or alteration results in a different therapeutic utility. In other embodiments, the CRBN conformational change or alteration results in a different substrate specificity. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has the atomic coordinates set forth in Table 8 as determined by x-ray diffraction. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a twenty-first aspect, provided herein is a complex comprising a CRBN and test compound, wherein said CRBN has a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) as compared to a conformational change of said CRBN contacted with a reference compound. Also provided herein is a complex comprising a CRBN and test compound, wherein said CRBN has a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) as compared to a conformational change of an unbound CRBN (e.g., a CRBN prior to contact with the test compound). In one embodiment, the CRBN has a conformational change. In a specific embodiment, the CRBN has a conformational change within the CMA-binding pocket of the CRBN. In another embodiment, the CRBN has an alteration of the properties of a CRBN surface. In a specific embodiment, the alteration of the properties of a CRBN surface are on an adjacent region of the protein. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having atomic coordinates set forth in Table 8. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a twenty-second aspect, provided herein is a method of identifying a substrate ubiquitinated by a E3 ubiquitination ligase complex comprising CRBN, said method comprising: (i) contacting said CRBN with a compound that induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), wherein said CRBN conformational change or alteration results in ubiquitination of said substrate, (ii) assaying for ubiquitination of one or more substrates, and (iii) identifying said one or more ubiquitinated substrates; wherein said substrate is not ubiquitinated by said E3 ubiquitination ligase complex in the absence of said compound. Also provided is a substrate identified by this method. In some embodiments, the conformational change or alteration is as compared to the CMA binding pocket when the CRBN is contacted with a reference compound. In some embodiments, the conformational change or alteration is as compared to the CMA binding pocket of an unbound CRBN (e.g., a CRBN prior to contact with the compound that induce a conformational change or alteration of the properties of the CRBN surface). In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound), and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure CRBN that is not bound to a reference compound (e.g., a CRBN prior to contact with the test compound); (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In one embodiment, the first three-dimensional structure of CRBN that is not bound to a reference compound has a three-dimensional structure as determined by x-ray diffraction having atomic coordinates set forth in Table 8. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In a specific embodiment, the CRBN is further bound to DDB1.

In a twenty-third aspect, provided herein is a method of recruiting a substrate for ubiquitination by a E3 ubiquitination ligase complex comprising CRBN, said method comprising contacting said CRBN with a compound that induces a conformational change of the CRBN (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), wherein said CRBN conformational change or alteration results in recruitment and ubiquitination of said substrate; and wherein said substrate is not ubiquitinated by said E3 ubiquitination ligase complex in the absence of said compound. In some embodiments, the induction of the conformational change or alteration is as compared of the CRBN (e.g., the CMA binding pocket of CRBN) or CRBN surface when the CRBN is contacted with a reference compound. In other embodiments, the induction of the conformational change or alteration is as compared of the CRBN (e.g., the CMA binding pocket of CRBN) or CRBN surface when the CRBN is unbound (e.g., prior to contact with the compound). In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In certain embodiments of the various compositions and methods provided herein, the crystal comprises a full-length CRBN protein. In other embodiments of the various compositions and methods provided herein, the crystal comprises a portion of the CRBN protein. In certain embodiments, the portion of the CRBN protein is a CMA binding domain. That is, in certain embodiments provided herein, methods that comprise obtaining a crystal comprising CRBN and a compound, includes without limitation obtaining a crystal comprising a CMA binding domain (i.e., not the full-length CRBN) and a compound. In some embodiments, the crystal comprises the thalidomide binding domain (TBD) (a type of a CMA-binding domain) of human CRBN (amino acids 319-427). In other embodiments, the crystal comprises the TBD of mouse CRBN (amino acids 322-430). Crystals comprising other CMA-binding domains are also contemplated.

In other embodiments of the various compositions and methods provided herein, the three-dimensional structure comprises a full-length CRBN protein. In other embodiments of the various compositions and methods provided herein, the three-dimensional structure comprises a portion of the CRBN protein. In certain embodiments, the portion of the CRBN protein is a CMA-binding domain. That is, in certain embodiments provided herein, methods that comprise obtaining a three-dimensional structure of a complex comprising CRBN and a compound, includes without limitation obtaining a three-dimensional structure of a complex comprising a CMA binding domain (i.e., not the full-length CRBN) and a compound. In some embodiments, the crystal comprises TBD of human CRBN (amino acids 319-427). In other embodiments, the crystal comprises the TBD of mouse CRBN (amino acids 322-430). Three-dimensional structures comprising other CMA-binding domains are also contemplated.

Exemplary methods of obtaining the crystal structure, e.g., of a CRBN (or a CMA-binding domain thereof), either alone or complexed with a CMA, are provided elsewhere herein.

In certain embodiments of the various compositions and methods provided herein, the atomic coordinates are set forth in Table 3. In other embodiments of the various compositions and methods provided herein, the atomic coordinates are set forth in Table 4. In some embodiments of the various compositions and methods provided herein, the atomic coordinates are set forth in Table 5. In some embodiments of the various compositions and methods provided herein, the atomic coordinates are set forth in Table 6. In some embodiments of the various compositions and methods provided herein, the atomic coordinates are set forth in Table 7.

In certain embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 3. In other embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 4. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 5. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 6. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 7. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is reflected by the atomic coordinates set forth in Table 8.

In certain embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in any one of the figures, including, for example, FIG. 12-18 or 20. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 12. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 13. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 14. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 15. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 16. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 17. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 18. In some embodiments of the various compositions and methods provided herein, the three-dimensional structure is provided in FIG. 20.

We further discovered that recruitment of a CRBN-associated protein (CAP) to CRBN, as well as subsequent degradation of the CAP by CRBN E3 ubiquitin ligase complex, is mediated by the CMA-induced conformational change in CRBN. The CAP recruited to CRBN depends on the specific CMA as well as a degron in the CAP. Based on the degron information, new CAPs can be identified and exploited as potential drug targets for treating various CRBN-related diseases.

As such, we describe herein a variety of degrons in a CAP, structural requirements of the degrons, and critical amino acid residues in the degrons. We also describe methods of identifying a CAP or a target of a treatment compound based on the degron information.

In a twenty-fourth aspect, provided herein is a degron in a CAP, wherein the degron is a structural degron.

In some embodiments, the structural degron comprises an α-turn. In other embodiments, the structural degron comprises a beta-hairpin.

In certain embodiments, the degron comprises 4 amino acid residues, with positions designated as i, i+1, i+2, and i+3, respectively.

In other embodiments, the degron further comprises an amino acid residue at position i−1.

In some embodiments, the amino acid residues at position i, i+1, or i+2 form hydrogen bonds with amino acid residues on CRBN. In one embodiment, the amino acid residue at position i form hydrogen bonds with amino acid residues on CRBN. In another embodiment, the amino acid residue at position i+1 form hydrogen bonds with amino acid residues on CRBN. In yet another embodiment, the amino acid residue at position i+2 form hydrogen bonds with amino acid residues on CRBN. In still another embodiment, the amino acid residues at positions i and i+1 form hydrogen bonds with amino acid residues on CRBN. In one embodiment, the amino acid residues at positions i and i+2 form hydrogen bonds with amino acid residues on CRBN. In another embodiment, the amino acid residues at positions i+1 and i+2 form hydrogen bonds with amino acid residues on CRBN. In yet another embodiment, the amino acid residues at position i, i+1, and i+2 form hydrogen bonds with amino acid residues on CRBN.

In certain embodiments, the amino acid residue at position i+3 is Glycine (G).

In some embodiments, the degron is stabilized by internal hydrogen bonds from an ASX motif and a ST motif.

In certain embodiments, the degron comprises an ASX motif that starts with Aspartic Acid (D). In other embodiments, the degron comprises an ASX motif that starts with Asparagine (N).

In some embodiments, the degron comprises a ST motif that starts with Serine (S). In other embodiments, the degron comprises a ST motif that starts with Threonine (T).

In certain embodiments, the degron comprises an amino acid sequence of [D/N]XX[S/T]G (SEQ ID NO:11), wherein X can be any amino acid residue. In one embodiment, the degron comprises an amino acid sequence of DXXSG (SEQ ID NO:12). In another embodiment, the degron comprises an amino acid sequence of NXXSG (SEQ ID NO:13). In yet another embodiment, the degron comprises an amino acid sequence of DXXTG (SEQ ID NO:14). In still another embodiment, the degron comprises an amino acid sequence of NXXTG (SEQ ID NO:15).

In some embodiments, the degron comprises an amino acid sequence of CXXCG (SEQ ID NO:16), wherein X can be any amino acid residue.

In certain embodiments, the degron comprises an amino acid sequence of NXXNG (SEQ ID NO:17), wherein X can be any amino acid residue.

In some embodiments, the CAP is a substrate of CRBN.

In one embodiment, the substrate of CRBN is GSPT1.

In another embodiment, the substrate of CRBN is IKZF1.

In yet another embodiment, the substrate of CRBN is CK1a.

In a twenty-fifth aspect, provided herein is a method of identifying a CAP, comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay; and (c) identifying the protein as a CAP if the protein specifically binds to CRBN in the CRBN-binding assay or ubiquitination assay. In some embodiments, the method comprises testing the protein in a CRBN-binding assay. In other embodiments, the method comprises testing the protein in an ubiquitination assay.

In certain embodiments, the CAP is a substrate of CRBN.

In some embodiments, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11).

In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO:16).

In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In certain embodiments, the CRBN-binding assay is performed in the presence of a compound.

In some embodiments, the compound is a CMA.

In other embodiments, the compound is an immunomodulatory compound.

In still other embodiments, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

In a twenty-sixth aspect, provided herein is a method of identifying a CAP, comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment; and (c) identifying the protein as a CAP if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay or proteomics experiments. In some embodiments, the method comprises testing the protein in a CRBN-mediated degradation assay. In other embodiments, the method comprises testing the protein in an ubiquitination assay. In yet other embodiments, the method comprises testing the protein in a proteomics experiment.

In certain embodiments, the CAP is a substrate of CRBN.

In some embodiments, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11).

In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO:16).

In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In certain embodiments, the CRBN-binding assay is performed in the presence of a compound.

In some embodiments, the compound is a CMA.

In other embodiments, the compound is an immunomodulatory compound.

In still other embodiments, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

In a twenty-seventh aspect, provided herein is a method of identifying a target of a compound comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein specifically binds to CRBN in the CRBN-binding assay or ubiquitination assay. In some embodiments, the method comprises testing the protein in a CRBN-binding assay in the presence of the compound. In other embodiments, the method comprises testing the protein in an ubiquitination assay in the presence of the compound.

In certain embodiments, the CAP is a substrate of CRBN.

In some embodiments, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11).

In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO:16).

In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In some embodiments, the compound is a CMA.

In other embodiments, the compound is an immunomodulatory compound.

In still other embodiments, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

In a twenty-eighth aspect, provided herein is a method of identifying a target of a compound comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay, or proteomics experiment in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay, or proteomics experiment. In some embodiments, the method comprises testing the protein in a CRBN-mediated degradation assay in the presence of the compound. In other embodiments, the method comprises testing the protein in an ubiquitination assay in the presence of the compound. In yet other embodiments, the method comprises testing the protein in a proteomics experiment in the presence of the compound.

In certain embodiments, the CAP is a substrate of CRBN.

In some embodiments, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11).

In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO: 16).

In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In some embodiments, the compound is a CMA.

In other embodiments, the compound is an immunomodulatory compound.

In still other embodiments, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

In a twenty-ninth aspect, provided herein is a method of identifying a CAP or a target of a compound comprising: searching for a protein that has a region of structural similarity to a degron region provided herein.

In some embodiments, provided herein is a method of identifying a CAP, comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay; and (c) identifying the protein as a CAP if the protein specifically binds to CRBN in the CRBN-binding assay or ubiquitination assay.

In other embodiments, provided herein is a method of identifying a CAP, comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment; and (c) identifying the protein as a CAP if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment.

In yet other embodiments, provided herein is a method of identifying a target of a compound comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein specifically binds to CRBN in the CRBN-binding assay or ubiquitination assay.

In yet other embodiments, provided herein is a method of identifying a target of a compound comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment.

In some embodiments of the various methods provided herein, the method comprises computationally searching for a protein based on the structural similarity to a degron provided herein. In one embodiment, the method provided herein comprises searching for a degron or a similar structure on the surface of proteins of known structure. In another embodiment, the method provided herein comprises searching for a similar structural feature to the known degron on the surface of proteins of known structure. In yet another embodiment, the method provided herein comprises searching for a glycine on the surface of proteins of known structure.

In certain embodiments, the CAP is a substrate of CRBN.

In some embodiments, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11).

In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO:16).

In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In certain embodiments, the CRBN-binding assay is performed in the presence of a compound.

In some embodiments, the compound is a CMA.

In other embodiments, the compound is an immunomodulatory compound.

In still other embodiments, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

In a thirtieth aspect, provided herein is a method of identifying a CAP or a target of a compound comprising: searching for a protein able to bind to a surface of CRBN adjacent to the site of ligand binding via features other than the known degron, e.g., by performing docking studies.

In some embodiments of the various methods provided herein, the method further comprises searching for proteins homologous to the proteins with the degron structure or predicted to have ability to bind CRBN.

4. BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts the differences in protein homeostasis following treatment with a CMA due to altered protein ubiquitination and degradation.

FIG. 2 depicts crystals of CRBN complexed with Apo (negative control), thalidomide, pomalidomide, Compound B, or Compound C. Identical projections of the CMA binding surfaces of CRBN show protein conformational changes.

FIGS. 3A-B depicts the crystal structure of Compound B in CRBN, in which the drug can act as a “molecular glue” or bridge with a substrate, such as a CRBN-associated protein. (A) Unbound mouse CRBN prior to Compound B binding, and (B) mouse CRBN in complex with Compound B.

FIG. 4 depicts a complex of CRBN and Compound B or thalidomide, and a 50° rotation of “pthalimide” ring in Compound B relative to thalidomide or pomalidomide is observed.

FIGS. 5A-B depict lenalidomide competes with Compound A and Compound C for CRBN. (A) and (B) Co-treatment of lenalidomide with either Compound A or Compound C blocks the anti-proliferative effects of either drug through competition of binding to the CRBN complex in both ABC and GCB DLBCL. Co-culture of Lenalidomide with either Compound A or Compound C dampens the activity of these compounds as they target the same binding pocket with relative affinity.

FIG. 6 shows that Compound C induced early apoptosis in the multiple myeloma (MM) cell line H929.

FIG. 7 shows that Compound C is potent across a panel of solid tumor lines.

FIG. 8 shows that Compound C binds CRBN protein MM cell extracts.

FIG. 9 shows that CRBN is required for the anti-proliferative activity of Compound C in myeloma cells.

FIG. 10 shows that CRBN is required for the anti-proliferative activity of Compound C in myeloma cells.

FIG. 11 shows that CRBN is required for both growth inhibition and pro-apoptotic activity of Compound C in the MDA-MB-213 breast cancer cells.

FIG. 12 shows the structure of human cereblon in complex with human DDB1. Lenalidomide binds the thalidomide binding domain (TBD; sometimes also referred to as immunomodulatory agent-binding domain (IBD) herein) (a type of CMA-binding domain) on the opposing face to the DDB1 binding motif. The Cereblon Lon-like domain (LLD) is shown in yellow. The TBD is shown in blue with the region deleted in a human polymorphism shown in red. DDB1 is shown in green with a grey surface. The DDB1 beta propeller domains are labeled BPA, BPB and BPC. Lenalidomide is shown as yellow sticks, and the zinc ion as a grey sphere.

FIG. 13 shows the structural superposition of cereblon with Bacillus subtilis lon protease (red, PDB code 3M65). The cereblon lon-like domain (LLD) is shown in yellow and the TBD is shown in blue. The DDB1 binding motif is inserted into the LLD, while the TBD exhibits no similarity to lon protease and occurs at the C-terminus.

FIG. 14 shows the structural superposition of cereblon:DDB1 (yellow and green, respectively) with DDB2:DDB1 (DDB2 shown in blue, DDB1 omitted). DDB1-binding is typically mediated by a helix-turn-helix motif such as helices c and d, which interact with the DDB1 beta-propellar C (BPC) domain. CRBN makes interactions with DDB1 BPC, but also places helix e to interact with the DDB1 beta-propeller A (BDA) domain.

FIG. 15 shows the TBD of human cereblon. The immunomodulatory agent binding domain is shown in blue, lenalidomide is shown in yellow sticks, the Lon-like domain is shown in the background in yellow. The immunomodulatory agent binding pocket is composed of 3 tryptophan residues: W380, W386 and W400. Three hydrogen bonds between the TBD and lenalidomide are shown as a dotted line to the protein backbone at H378 and W380 and to the sidechain of H378. The zinc binding site is shown as a grey sphere, and is approximately 18 Å from lenalidomide. The beta sheet region which varies in the other structures is marked by a ‘β’.

FIG. 16 shows the murine TBD in complex with thalidomide.

FIG. 17 shows the murine TBD in complex with pomalidomide.

FIG. 18 shows the structural superposition of cereblon TBD (blue) with methionine sulfoxide reductase (green) and RIG-I (magenta).

FIG. 19 shows the sequence alignment differences mapped onto the surface of the immunomodulatory agent-binding domain of cereblon. Conserved residues relative to the human protein are shown in red, conservative changes are shown in orange, nonconservative changes are shown in white. The immunomodulatory agent binding pocket is indicated by a blue arrow. Tryptophan residues directly involved in immunomodulatory agent binding are shown in bold in the sequence alignment. The immunomodulatory agent-binding pocket demonstrates extremely high conservation across plant and animal kingdoms. Homo: SEQ ID NO:1, Macaca: SEQ ID NO:1, Mus: SEQ ID NO:2, Rattus: SEQ ID NO:2, Drosophila melanogaster: SEQ ID NO:3, and Glycine max: SEQ ID NO:4.

FIG. 20 shows the TBD of murine cereblon showing the crystal contacts formed between protein monomers, bridged by thalomide molecules.

FIGS. 21A-21C shows a CRBN-binding assay with thalidomide enantiomers. (A) Competitive elution assay using thalidomide-immobilized beads coupled with racemic thalidomide. Beads were washed three times with 0.5% NP-40 lysis buffer and bound proteins were eluted with wash buffer containing 1 mM S-, R-thalidomide (S-Thal or R-Thal) or 0.1% DMSO for the indicated time. The eluate was then analyzed by SDS-PAGE and immunoblotting (IB). (B) Same as A, but eluted with a buffer solution containing the indicated concentrations of S- or R-thalidomide (S- or R-Thal). (C) Inhibitory effects of thalidomide enantiomers on auto-ubiquitylation of FH-CRBN was detected in the presence of MG132. Cells were treated with DMSO or the indicated concentrations of S- or R-thalidomide for 4 hours prior to harvesting.

FIG. 22 shows Phylogenetically conserved tryptophan residues (W386 and W400) confer binding of CRBN to immunomodulatory agent and are required for immunomodulatory agent function in vivo. (A) Cell lines re-expressing full-length CRBN wild-type. W386A or W400A mutants were tested for the ability to bind immunomodulatory agent compounds. Assay was repeated at least three times. Representative Western blot of representative experiment is shown. (B) Cell proliferation assay of DF15 (sensitive). DF15R (resistant; CRBN^(null)), CRBNWT, CRBNW386A; CRBN400 cells treated with a dose response of pomalidomide. Assays were done in triplicate and error bars representative s.d. Data for each cell line was normalized to treatment with vehicle (DMSO). (C) Western blots of key downstream effectors of immunomodulatory agent resistance.

FIGS. 23A-23B shows the effects of E377V mutation on CRBN activity in vivo. (A) Cell lines re-expressing RFP or full length CRBN wild type or E377V mutant were tested for the ability of CRBN proteins to bind immunomodulatory agent compounds. Assay was repeated at least three times. Representative Western blot of representative experiment is shown. (B) Cell proliferation assay of DF15 (sensitive), DF15R (resistant; CRBN^(null)), CRBN^(WT), CRBN^(E377V) cells treated with a dose response of pomalidomide. Assays were done in triplicate and error bars represent s.d. Data for each cell line was normalized to treatment with vehicle (DMSO). The insert shows Western blots of Aiolos and β-actin.

FIGS. 24A-24D shows CRBN in lysates from DF15. (A) Immunoblot analysis of CRBN in lysates from DF15, DF15R, DF15R RFP (RFP ctrl), DF15R CRBN^(WT) (CRBN wt), DF15R CRBN^(W386A) and CRBN^(W400A) cells. (B) CRBN analysis in DF15 and DF15R and DF15R-derived cell lines by immunohistochemistry confocal microscopy. Images were obtained using a Nikon E800 confocal microscope at a 40× magnification. CRBN signal is shown in cytoplasm and nucleus of the calls. DAPI staining identifies the nucleus of cells (darker staining). (C) Immunoblot of anti-FLAG immunoprecipitation from cell extracts using FLAG-tagged CRBN proteins. (D) Immunoblot of thalidomide analog affinity bead binding to CRBN in DF15, DF15R and DF15R CRBN^(WT) cell extracts. Lane description in order (left to right): In=DF15 input prior to bead purification; V=DF15 extract control (1% DMSO preincubation); Len=DF15R extract preincubated with lenalidomide (30 μM); Pom=DF15R extract preincubated with pomalidomide (30 μM); In=DF15R CRBN^(WT) input prior to bead purification; V=DF15R CRBN^(WT) control (1% DMSO preincubation); Len=DF15R CRBN^(WT) extract preincubated with lenalidomide (30 μM); Pom=DF15R CRBN^(WT) extract preincubated with pomalidomide (30 μM) Representative immunoblot from two independent experiments with similar results are shown.

FIGS. 25A-25F show that CRBN inducible-knockdown cells had a dose and time dependent shRNA induction as measured by an increase in the percentage of RFP positive cells. (A) An inducible shRNA construct targeting CRBN or a control construct was transduced into the multiple myeloma cell lines H929 and U266. Inducible shRNA expression (marked by turbo-RFP) was monitored by flow cytometry over a period of 1 to 9 days as indicated in the histograms (Top row). Annexin V assay staining demonstrated that following induction with doxycycline treatment, CRBN inducible-knockdown did not result in cell death (A Bottom row & C). (B) CRBN protein expression was quantified by Western blotting. CRBN inducible-knockdown cells showed no significant changes in IRF4 or actin protein levels. (C) Following doxycycline treatment, CRBN inducible-knockdown in H929 and U266 cells showed no effect in viability as measured by Annexin V+7AAD staining and analyzed by flow cytometry over a period of 1-9 days. (D)-(F) After 9 days of shRNA inducible knock-down, cells were treated with increasing doses of pomalidomide and compound effect in cell viability was assayed by flow cytometry after 5 day treatment. In CRBN inducible knockdown cells, pomalidomide had reduced anti-proliferative effects compared to shControl knockdown cells. Data are shown as mean of three independent experiments±s.d.

FIG. 26 shows IL2 costimulation by pomalidomide. (A) Co-stimulation of IL2 release by pomalidomide in human PBMCs treated with anti-CD3. Data are shown as mean±s.d. (B) Costimulation of IL2 release by anti-CD28 (squares) or pomalidomide (circles) in mouse PBMC treated with anti-CD3. Data are shown as mean±s.d.

FIG. 27 shows V388 is essential for the degradation of IKZF1/3 by lenalidomide.

FIGS. 28A-28C show that (A) a truncation mutant of human GSPT1 lacking the N-terminal 138 amino acid residues (B) is still destabilized by Compound C in 293T HEK cells, and (C) consistent with the ability of this mutant to capture CRBN in the presence of Compound C.

FIGS. 29A-29B show that (A) the yeast homologue SUP35 shares a high degree of sequence homology with human GSPT1, (B) but did not show any changes at the protein level in response to Compound C treatment. Human GSPT1 (hGSPT1): SEQ ID NO:5, and yeast homologue SUP35 (scSUP35): SEQ ID NO:6.

FIGS. 30A-30D show that a 32-amino acid fragment in the C-terminus of human GSPT1 (residues 562 to 593), when replaced with the corresponding region of SUP35, completely blocked the Compound C-induced degradation of GSPT1. (A) Constructs generated through domain swapping between human GSPT1 and yeast SUP35. (B-D) Western blot showing the degradation of various GSPT1 constructs in response to the Compound C treatment.

FIGS. 31A-31C show that (A) conversion of glycine 575 of human GSPT1 into the corresponding asparagine of yeast SUP35 (B) prevented the Compound C-induced degradation of GSPT1 and (C) the Compound C-induced in vitro binding of GSPT1 to CRBN. hGSPT1: SEQ ID NO:7; mGSPT1: SEQ ID NO:7; hGSPT2: SEQ ID NO:8; mGSPT2: SEQ ID NO:8; hHBS1L: SEQ ID NO:9; mHBS1L: SEQ ID NO:9; and scSUP35: SEQ ID NO:10.

FIGS. 32A-32B show that a G575N mutation in human GSPT1 prevented (A) the Compound C-induced growth inhibition and (B) the Compound C-induced activation of ATF4 and apoptosis pathways.

FIGS. 33A-33E show a chemical structure of (A) lenalidomide, (B) pomalidomide, (C) Compound C, (D) structure of complex GSPT1-CRBN-DDB1, (E) detail of the interface between CRBN and GSPT1 with Compound C shown as sticks with carbons in yellow.

FIGS. 34A-34C show excellent agreement between structure and mutational analysis. (A) CRBN immunoprecipitation assay of various mutated forms of CRBN in the absence or presence of Compound C. (B) Structure indicating mapped SUP35 region in yellow. (C) Structure indicating positions of mutations on CRBN surface: red—disrupting binding; green—no effect on binding; orange—partially disrupting binding; and blue—no mutations tested.

FIGS. 35A-35D show the details of interaction between Compound C and CRBN-GSPT1 complex. (A) glutarimide group. (B) isoindolinone group. (C) urea group. (D) methyl-chloro-phenyl group.

FIGS. 36A-36B show non-conserved residues in red between (A) GSPT1 and GSPT2, (B) between GSPT1 and HBS1L.

FIG. 37 shows backbone-mediated interactions between CRBN and GSPT1 in the presence of Compound C.

FIG. 38 shows that the key anchoring motif of GSPT1 is stabilized by internal hydrogen bonds from ASX and ST motifs.

FIGS. 39A-39B show the effect of CRBN surface mutations on substrate binding. (A) Immunoprecipitation of GSPT1. (B) Immunoprecipitation of IKZF1.

FIGS. 40A-40B map the effect of mutations on CRBN surface upon substrate binding: (A) GSPT1 binding and (B) IKZF1 binding. Red—strong reduction in substrate binding; orange—some reduction; green—no effect; blue—not tested.

FIGS. 41A-41B show (A) the anchoring motif of GSPT1 (blue) bound to CRBN (green) and Compound C (yellow); (B) a model of IKZF1 (magenta) superposed upon the backnone of GSPT1 (blue); (C) immunopricipitation of CRBN-DDB1 with alanine mutations of the GSPT1 anchoring motif; (D) immunopricipitation of CRBN-DDB1 with alanine mutations of the IKZF1 anchoring motif; (E) sequence alignment of the GSPT1 anchoring motif with the putative region from IKZF1, with residues critical for binding shown to be red. The critical glycine is shown in bold.

FIG. 42 shows that CRBN-CK1a complex model superposes with the anchoring motif of CRBN-GSPT1 complex.

FIGS. 43A-43B show the effect of lenalidomide or Compound C on IKZF1 and GSPT1 degradation. (A) shows the effect with human CRBN. (B) shows the effect with mouse CRBN.

5. DETAILED DESCRIPTION

The compositions, methods and kits provided herein are based, in part, on the discovery that E3 ubiquitin ligases, including CRBN, undergo conformational changes or otherwise alter the surface, upon ligand (e.g., CMA) binding. As shown in FIG. 1, CRBN binds proteins, such as DDB1, Cul4 and Roc1 to form a E3-ubiquitan ligase complex, which serve to facilitate targeted protein ubiquitination and degradation. In the presence of a CMA, the CRBN complex has an altered binding specificity and subsequent downstream biological effects. CRBN is believed to act as a novel substrate receptor for the complex. Without wishing to be bound by theory, it is believed that this ligand-dependent E3 ubiquitin ligase (e.g., CRBN) conformational change or alteration results in different E3 ubiquitin ligase surfaces being exposed, thereby affecting the recruitment and engagement of different substrates to the E3 ubiquitin ligase complex and resulting in the downstream differential phenotypic and/or therapeutic effects. In addition, ligands (including CMAs) provide binding interactions for the various different protein substrates. In specific embodiments, the E3 ubiquitin ligase is CRBN, and the CRBN ligands include CMAs, such as Compound C, or any analog thereof.

5.1 Definitions

All patents, applications, published applications and other publications are incorporated by reference in their entirety. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. All patents, applications, published applications and other publications are incorporated herein by reference in their entirety. In the event that there is a plurality of definitions for a term herein, those in this section prevail unless stated otherwise.

The term “about” or “approximately” means within 20%, within 10%, and within 5% (or 1% or less) of a given value or range.

As used herein, the term “degron” refers to a sequence of amino acid in a protein, e.g., a sequence in a protein that directs the starting place of degradation.

As used herein, “administer” or “administration” refers to the act of injecting or otherwise physically delivering a substance as it exists outside the body into a patient, such as by mucosal, intradermal, intravenous, intramuscular delivery and/or any other method of physical delivery described herein or known in the art. When a disease, disorder or condition, or a symptom thereof, is being treated, administration of the substance typically occurs after the onset of disease, disorder or condition or symptoms thereof. When a disease, disorder or condition, or symptoms thereof, are being prevented, administration of the substance typically occurs before the onset of the disease, disorder or condition or symptoms thereof.

“Biological sample” as used herein refers to a sample obtained from a biological subject, including sample of biological tissue or fluid origin, obtained, reached, or collected in vivo or in situ. A biological sample also includes samples from a region of a biological subject containing precancerous or cancer cells or tissues. Such samples can be, but are not limited to, organs, tissues, fractions and cells isolated from a mammal. Exemplary biological samples include but are not limited to cell lysate, a cell culture, a cell line, a tissue, oral tissue, gastrointestinal tissue, an organ, an organelle, a biological fluid, a blood sample, a urine sample, a skin sample, and the like. Preferred biological samples include but are not limited to whole blood, partially purified blood, PBMCs, tissue biopsies, and the like.

A biological marker or “biomarker” is a substance whose detection indicates a particular biological state, such as, for example, the presence of cancer. In some embodiments, biomarkers can either be determined individually, or several biomarkers can be measured simultaneously. In some embodiments, a “biomarker” indicates a change in the level of mRNA expression that may correlate with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. In some embodiments, the biomarker is a nucleic acid, such as a mRNA or cDNA. In additional embodiments, a “biomarker” indicates a change in the level of polypeptide or protein expression that may correlate with the risk, susceptibility to treatment, or progression of a disease. In some embodiments, the biomarker can be a polypeptide or protein, or a fragment thereof. The relative level of specific proteins can be determined by methods known in the art. For example, antibody based methods, such as an immunoblot, enzyme-linked immunosorbent assay (ELISA), or other methods can be used.

The terms “cancer” and “cancerous” refer to or describe the physiological condition in mammals that is typically characterized by unregulated cell growth. Examples of cancer include, but are not limited to, blood-borne tumors (e.g., multiple myeloma, lymphoma and leukemia), and solid tumors. Other exemplary cancers are provided elsewhere herein.

The term “capture agent,” as used herein, refers to an agent that binds an mRNA or protein through an interaction that is sufficient to permit the agent to bind and concentrate the mRNA or protein from a homogeneous mixture.

The terms “cereblon” or “CRBN” and similar terms refers to the polypeptides (“polypeptides,” “peptides” and “proteins” are used interchangeably herein) comprising the amino acid sequence any CRBN, such as a human CRBN protein (e.g., human CRBN isoform 1, GenBank Accession No. NP_057386; or human CRBN isoforms 2, GenBank Accession No. NP_001166953, each of which is herein incorporated by reference in its entirety), and related polypeptides, including SNP variants thereof. Related CRBN polypeptides include allelic variants (e.g., SNP variants); splice variants; fragments; derivatives; substitution, deletion, and insertion variants; fusion polypeptides; and interspecies homologs, which, in certain embodiments, retain CRBN activity and/or are sufficient to generate an anti-CRBN immune response.

As used herein, the term “cereblon-associated protein” or “CRBN-associated protein” refers to a protein that interacts with or binds to CRBN directly or indirectly. In certain embodiments, a “cereblon-associated protein” or “CRBN-associated protein” is a substrate of CRBN, for example, a protein substrate of the E3 ubiquitin ligase complex involving CRBN, or the downstream substrates thereof. In one embodiment, the CRBN-associated protein provided herein is a substrate of CRBN such as IKZF3, also known as “Aiolos,” and/or IKZF1, also known as “Ikaros.” In certain embodiments, a “cereblon-associated protein” or “CRBN-associated protein” is a binding protein of CRBN.

As used herein and unless otherwise indicated, the term “co-crystal” means a crystalline form that contains more than one compound in a crystal lattice. Co-crystals include crystalline molecular complexes of two or more non-volatile compounds bound together in a crystal lattice through non-ionic interactions. As used herein, co-crystals include pharmaceutical cocrystals wherein the crystalline molecular complexes containing a therapeutic compound and one or more additional non-volatile compound(s) (referred to herein as counter-molecule(s)). A counter-molecule in a pharmaceutical cocrystal is typically a non-toxic pharmaceutically acceptable molecule, such as, for example, food additives, preservatives, pharmaceutical excipients, or other APIs. In some embodiments, pharmaceutical cocrystals enhance certain physicochemical properties of drug products (e.g., solubility, dissolution rate, bioavailability and/or stability). without compromising the chemical structural integrity of the active pharmaceutical ingredient (API). See, e.g., Jones et al., “Pharmaceutical Cocrystals: An Emerging Approach to Physical Property Enhancement,” MRS Bulletin, 2006, 31, 875-879; Trask, “An Overview of Pharmaceutical Cocrystals as Intellectual Property,” Molecular Pharmaceutics, 2007, 4(3), 301-309; Schultheiss & Newman, “Pharmaceutical Cocrystals and Their Physicochemical Properties,” Crystal Growth & Design, 2009, 9(6), 2950-2967; Shan & Zaworotko, “The Role of Cocrystals in Pharmaceutical Science,” Drug Discovery Today, 2008, 13(9/10), 440-446; and Vishweshwar et al., “Pharmaceutical Co-Crystals,” J. Pharm. Sci., 2006, 95(3), 499-516.

The term “complementary” refers to specific binding between polynucleotides based on the sequences of the polynucleotides. As used herein, a first polynucleotide and a second polynucleotide are complementary if they bind to each other in a hybridization assay under stringent conditions, e.g. if they produce a given or detectable level of signal in a hybridization assay. Portions of polynucleotides are complementary to each other if they follow conventional base-pairing rules, e.g. A pairs with T (or U) and G pairs with C, although small regions (e.g. less than about 3 bases) of mismatch, insertion, or deleted sequence may be present.

An improvement in the cancer or cancer-related disease can be characterized as a complete or partial response. “Complete response” refers to an absence of clinically detectable disease with normalization of any previously abnormal radiographic studies, bone marrow, and cerebrospinal fluid (CSF) or abnormal monoclonal protein measurements. “Partial response” refers to at least about a 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% decrease in all measurable tumor burden (i.e., the number of malignant cells present in the subject, or the measured bulk of tumor masses or the quantity of abnormal monoclonal protein) in the absence of new lesions. The term “treatment” contemplates both a complete and a partial response.

As used herein, the term “composition” is intended to encompass a product containing the specified ingredients (e.g., an antibody provided herein) and, optionally, in the specified amounts, as well as any product which results, directly or indirectly, from combination of the specified ingredients in, optionally, the specified amounts.

The term “cycle number” or “CT” when used herein in reference to PCR methods, refers to the PCR cycle number at which the fluorescence level passes a given set threshold level. The CT measurement can be used, for example, to approximate levels of mRNA in an original sample. The CT measurement is often used in terms of “dCT” or the “difference in the CT” score, when the CT of one nucleic acid is subtracted from the CT of another nucleic acid.

The terms “determining”, “measuring”, “evaluating”, “assessing” and “assaying” as used herein generally refer to any form of measurement, and include determining if an element is present or not. These terms include both quantitative and/or qualitative determinations. Assessing may be relative or absolute. “Assessing the presence of” can include determining the amount of something present, as well as determining whether it is present or absent.

The term “effective amount” as used herein refers to the amount of a therapy (e.g., a composition provided herein) which is sufficient to reduce and/or ameliorate the severity and/or duration of a given disease, disorder or condition and/or a symptom related thereto. This term also encompasses an amount necessary for the reduction or amelioration of the advancement or progression of a given disease, disorder or condition, reduction or amelioration of the recurrence, development or onset of a given disease, disorder or condition, and/or to improve or enhance the prophylactic or therapeutic effect(s) of another therapy. In some embodiments, “effective amount” as used herein also refers to the amount of therapy provided herein to achieve a specified result.

As used herein, an “effective patient tumor response” refers to any increase in the therapeutic benefit to the patient. An “effective patient tumor response” can be, for example, a 5%, 10%, 25%, 50%, or 100% decrease in the rate of progress of the tumor. An “effective patient tumor response” can be, for example, a 5%, 10%, 25%, 50%, or 100% decrease in the physical symptoms of a cancer. An “effective patient tumor response” can also be, for example, a 5%, 10%, 25%, 50%, 100%, 200%, or more increase in the response of the patient, as measured by any suitable means, such as gene expression, cell counts, assay results, etc.

The term “expressed” or “expression” as used herein refers to the transcription from a gene to give an RNA nucleic acid molecule at least complementary in part to a region of one of the two nucleic acid strands of the gene. The term “expressed” or “expression” as used herein also refers to the translation from the RNA molecule to give a protein, a polypeptide or a portion thereof.

The term “CRBN modifying agent” or “CMA” refers to a molecule that directly or indirectly modulating the CRBN E3 ubiquitin-ligase complex. In some embodiments, the CMA can bind directly to CRBN and induce conformational change in the CRBN protein. In other embodiments, the CMA can bind directly to other subunits in the CRBN E3 ubiquitin-ligase complex.

As used herein, the term “immunomodulatory compound” or “immunomodulatory drug” refers generally to a molecule or agent capable of altering the immune response in some way. Non-limiting examples of immunomodulatory compounds include those disclosed in Section 5.9 below.

The terms “isolated” and “purified” refer to isolation of a substance (such as mRNA, antibody or protein) such that the substance comprises a substantial portion of the sample in which it resides, i.e. greater than the substance is typically found in its natural or un-isolated state. Typically, a substantial portion of the sample comprises, e.g., greater than 1%, greater than 2%, greater than 5%, greater than 10%, greater than 20%, greater than 50%, or more, usually up to about 90%-100% of the sample. For example, a sample of isolated mRNA can typically comprise at least about 1% total mRNA. Techniques for purifying polynucleotides are well known in the art and include, for example, gel electrophoresis, ion-exchange chromatography, affinity chromatography, flow sorting, and sedimentation according to density.

A “label” or a “detectable moiety” in reference to a nucleic acid, refers to a composition that, when linked with a nucleic acid, renders the nucleic acid detectable, for example, by spectroscopic, photochemical, biochemical, immunochemical, or chemical means. Exemplary labels include, but are not limited to, radioactive isotopes, magnetic beads, metallic beads, colloidal particles, fluorescent dyes, enzymes, biotin, digoxigenin, haptens, and the like. A “labeled nucleic acid or oligonucleotide probe” is generally one that is bound, either covalently, through a linker or a chemical bond, or noncovalently, through ionic bonds, van der Waals forces, electrostatic attractions, hydrophobic interactions, or hydrogen bonds, to a label such that the presence of the nucleic acid or probe can be detected by detecting the presence of the label bound to the nucleic acid or probe.

The term “likelihood” generally refers to an increase in the probability of an event. The term “likelihood” when used in reference to the effectiveness of a patient tumor response generally contemplates an increased probability that the rate of tumor progress or tumor cell growth will decrease. The term “likelihood” when used in reference to the effectiveness of a patient tumor response can also generally mean the increase of indicators, such as mRNA or protein expression, that may evidence an increase in the progress in treating the tumor.

As used herein, the terms “manage,” “managing,” and “management” refer to the beneficial effects that a subject derives from a therapy, which does not result in a cure of the disease, disorder or condition. In certain embodiments, a subject is administered one or more therapies to “manage” a disease, disorder or condition, or one or more symptoms thereof, so as to prevent the progression or worsening of the disease, disorder or condition.

The term “monitor,” as used herein, generally refers to the overseeing, supervision, regulation, watching, tracking, or surveillance of an activity. For example, the term “monitoring the effectiveness of a compound” refers to tracking the effectiveness in treating a cancer in a patient or in a tumor cell culture. Similarly, the “monitoring,” when used in connection with patient compliance, either individually, or in a clinical trial, refers to the tracking or confirming that the patient is actually taking a drug being tested as prescribed. The monitoring can be performed, for example, by following the expression of mRNA or protein biomarkers.

The terms “nucleic acid” and “polynucleotide” are used interchangeably herein to describe a polymer of any length composed of nucleotides, e.g., deoxyribonucleotides or ribonucleotides, or compounds produced synthetically, which can hybridize with naturally occurring nucleic acids in a sequence specific manner analogous to that of two naturally occurring nucleic acids, e.g., can participate in Watson-Crick base pairing interactions. As used herein in the context of a polynucleotide sequence, the term “bases” (or “base”) is synonymous with “nucleotides” (or “nucleotide”), i.e., the monomer subunit of a polynucleotide. The terms “nucleoside” and “nucleotide” are intended to include those moieties that contain not only the known purine and pyrimidine bases, but also other heterocyclic bases that have been modified. Such modifications include methylated purines or pyrimidines, acylated purines or pyrimidines, alkylated riboses or other heterocycles. In addition, the terms “nucleoside” and “nucleotide” include those moieties that contain not only conventional ribose and deoxyribose sugars, but other sugars as well. Modified nucleosides or nucleotides also include modifications on the sugar moiety, e.g., wherein one or more of the hydroxyl groups are replaced with halogen atoms or aliphatic groups, or are functionalized as ethers, amines, or the like. “Analogues” refer to molecules having structural features that are recognized in the literature as being mimetics, derivatives, having analogous structures, or other like terms, and include, for example, polynucleotides incorporating non-natural nucleotides, nucleotide mimetics such as 2′-modified nucleosides, peptide nucleic acids, oligomeric nucleoside phosphonates, and any polynucleotide that has added substituent groups, such as protecting groups or linking moieties.

As used herein, the term “nucleotide,” nucleic acid,” “nucleic acid molecule,” “polynucleotide,” and other similar terms are used interchangeable and include DNA, RNA, mRNA and the like.

The term “nucleic acid” or “oligonucleotide probe” refers to a nucleic acid capable of binding to a target nucleic acid of complementary sequence, such as the mRNA biomarkers provided herein, through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (e.g., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. It will be understood by one of skill in the art that probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions. The probes are preferably directly labeled with isotopes, for example, chromophores, lumiphores, chromogens, or indirectly labeled with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of a target mRNA biomarker of interest.

As used herein, and unless otherwise indicated, the term “optically pure” means a composition that comprises one optical isomer of a compound and is substantially free of other isomers of that compound. For example, an optically pure composition of a compound having one chiral center will be substantially free of the opposite enantiomer of the compound. An optically pure composition of a compound having two chiral centers will be substantially free of other diastereomers of the compound. A typical optically pure compound comprises greater than about 80% by weight of one enantiomer of the compound and less than about 20% by weight of other enantiomers of the compound, greater than about 90% by weight of one enantiomer of the compound and less than about 10% by weight of the other enantiomers of the compound, greater than about 95% by weight of one enantiomer of the compound and less than about 5% by weight of the other enantiomers of the compound, greater than about 97% by weight of one enantiomer of the compound and less than about 3% by weight of the other enantiomers of the compound, and greater than about 99% by weight of one enantiomer of the compound and less than about 1% by weight of the other enantiomers of the compound.

The terms “optional” or “optionally” as used herein means that the subsequently described event or circumstance may or may not occur, and that the description includes, without limitation, instances where said event or circumstance occurs and instances in which it does not.

The term “pharmaceutically acceptable” as used herein means being approved by a regulatory agency of the Federal or a state government, or listed in the U.S. Pharmacopeia, European Pharmacopeia or other generally recognized Pharmacopeia for use in animals, and more particularly in humans.

As used herein and unless otherwise indicated, the term “pharmaceutically acceptable salt” encompasses non-toxic acid and base addition salts of the compound to which the term refers. Acceptable non-toxic acid addition salts include those derived from organic and inorganic acids or bases know in the art, which include, for example, hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, methanesulphonic acid, acetic acid, tartaric acid, lactic acid, succinic acid, citric acid, malic acid, maleic acid, sorbic acid, aconitic acid, salicylic acid, phthalic acid, embolic acid, enanthic acid, and the like.

Compounds that are acidic in nature are capable of forming salts with various pharmaceutically acceptable bases. The bases that can be used to prepare pharmaceutically acceptable base addition salts of such acidic compounds are those that form non-toxic base addition salts, i.e., salts containing pharmacologically acceptable cations such as, but not limited to, alkali metal or alkaline earth metal salts and the calcium, magnesium, sodium or potassium salts in particular. Suitable organic bases include, but are not limited to, N,N-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumaine (N-methylglucamine), lysine, and procaine.

The terms “polymerase chain reaction,” or “PCR,” as used herein generally refers to a procedure wherein small amounts of a nucleic acid, RNA and/or DNA, are amplified as described, for example, in U.S. Pat. No. 4,683,195 to Mullis. Generally, sequence information from the ends of the region of interest or beyond needs to be available, such that oligonucleotide primers can be designed; these primers will be identical or similar in sequence to opposite strands of the template to be amplified. The 5′ terminal nucleotides of the two primers may coincide with the ends of the amplified material. PCR can be used to amplify specific RNA sequences, specific DNA sequences from total genomic DNA, and cDNA transcribed from total cellular RNA, bacteriophage or plasmid sequences, etc. See generally Mullis et al., Cold Spring Harbor Symp. Quant. Biol., 51: 263 (1987); Erlich, ed., PCR Technology, (Stockton Press, N Y, 1989).

As used herein the terms “polypeptide” and “protein” as used interchangeably herein, refer to a polymer of amino acids of three or more amino acids in a serial array, linked through peptide bonds. The term “polypeptide” includes proteins, protein fragments, protein analogues, oligopeptides and the like. The term polypeptide as used herein can also refer to a peptide. The amino acids making up the polypeptide may be naturally derived, or may be synthetic. The polypeptide can be purified from a biological sample.

The term “predict” generally means to determine or tell in advance. When used to “predict” the effectiveness of a cancer treatment, for example, the term “predict” can mean that the likelihood of the outcome of the cancer treatment can be determined at the outset, before the treatment has begun, or before the treatment period has progressed substantially.

As used herein, the term “prophylactic agent” refers to any agent that can totally or partially inhibit the development, recurrence, onset or spread of a disease, disorder or condition and/or symptom related thereto in a subject. In certain embodiments, the term “prophylactic agent” refers to a compound provided herein. In certain other embodiments, the term “prophylactic agent” refers to an agent other than a compound provided herein. In certain embodiments, a prophylactic agent is an agent which is known to be useful to or has been or is currently being used to prevent a disease, disorder or condition and/or a symptom related thereto or impede the onset, development, progression and/or severity of a disease, disorder or condition and/or a symptom related thereto.

The term “probe” as used herein, refers to a capture agent that is directed to a specific target mRNA biomarker sequence. Accordingly, each probe of a probe set has a respective target mRNA biomarker. A probe/target mRNA duplex is a structure formed by hybridizing a probe to its target mRNA biomarker.

The term “refractory or resistant” refers to a circumstance where patients, even after intensive treatment, have residual cancer cells (e.g., leukemia or lymphoma cells) in their lymphatic system, blood and/or blood forming tissues (e.g., marrow).

The term “regulate” as used herein refers to controlling the activity of a molecule or biological function, such as enhancing or diminishing the activity or function.

The term “sample” as used herein relates to a material or mixture of materials, typically, although not necessarily, in fluid form, containing one or more components of interest.

The term “sensitivity” and “sensitive” when made in reference to treatment with compound is a relative term which refers to the degree of effectiveness of the compound in lessening or decreasing the progress of a tumor or the disease being treated. For example, the term “increased sensitivity” when used in reference to treatment of a cell or tumor in connection with a compound refers to an increase of, at least a 5%, or more, in the effectiveness of the tumor treatment.

“Sequence identity” or “identity” in the context of two nucleic acid sequences refers to the residues in the two sequences which are the same when aligned for maximum correspondence over a specified comparison window, and can take into consideration additions, deletions and substitutions.

As used herein and unless otherwise indicated, the term “solvate” means a compound provided herein or a salt thereof, that further includes a stoichiometric or non-stoichiometric amount of solvent bound by non-covalent intermolecular forces. Where the solvent is water, the solvate is a hydrate.

As used herein and unless otherwise indicated, the term “stereomerically pure” means a composition that comprises one stereoisomer of a compound and is substantially free of other stereoisomers of that compound. For example, a stereomerically pure composition of a compound having one chiral center will be substantially free of the opposite enantiomer of the compound. A stereomerically pure composition of a compound having two chiral centers will be substantially free of other diastereomers of the compound. A typical stereomerically pure compound comprises greater than about 80% by weight of one stereoisomer of the compound and less than about 20% by weight of other stereoisomers of the compound, greater than about 90% by weight of one stereoisomer of the compound and less than about 10% by weight of the other stereoisomers of the compound, greater than about 95% by weight of one stereoisomer of the compound and less than about 5% by weight of the other stereoisomers of the compound, and greater than about 97% by weight of one stereoisomer of the compound and less than about 3% by weight of the other stereoisomers of the compound. As used herein and unless otherwise indicated, the term “stereomerically enriched” means a composition that comprises greater than about 60% by weight of one stereoisomer of a compound, greater than about 70% by weight, greater than about 80% by weight of one stereoisomer of a compound. As used herein and unless otherwise indicated, the term “enantiomerically pure” means a stereomerically pure composition of a compound having one chiral center. Similarly, the term “stereomerically enriched” means a stereomerically enriched composition of a compound having one chiral center.

The term “stringent assay conditions” refers to conditions that are compatible to produce binding pairs of nucleic acids, e.g., probes and target mRNAs, of sufficient complementarity to provide for the desired level of specificity in the assay while being generally incompatible to the formation of binding pairs between binding members of insufficient complementarity to provide for the desired specificity. The term stringent assay conditions generally refers to the combination of hybridization and wash conditions.

As used herein, the terms “subject” and “patient” are used interchangeably. As used herein, a subject can be a mammal such as a non-primate (e.g., cows, pigs, horses, cats, dogs, rats, etc.) or a primate (e.g., monkey and human). In specific embodiments, the subject is a human. In one embodiment, the subject is a mammal (e.g., a human) having a disease, disorder or condition. In another embodiment, the subject is a mammal (e.g., a human) at risk of developing a disease, disorder or condition.

The term “substantial identity” or “homologous” in their various grammatical forms in the context of polynucleotides generally means that a polynucleotide comprises a sequence that has a desired identity, for example, at least 60% identity, at least 70% sequence identity, at least 80%, at least 90% and at least 95%, compared to a reference sequence. Another indication that nucleotide sequences are substantially identical is if two molecules hybridize to each other under stringent conditions.

As used herein, and unless otherwise specified, the term “therapeutically effective amount” of a compound is an amount sufficient to provide a therapeutic benefit in the treatment or management of a cancer, or to delay or minimize one or more symptoms associated with the presence of the cancer. A therapeutically effective amount of a compound means an amount of therapeutic agent, alone or in combination with other therapies, which provides a therapeutic benefit in the treatment or management of the cancer. The term “therapeutically effective amount” can encompass an amount that improves overall therapy, reduces or avoids symptoms or causes of cancer, or enhances the therapeutic efficacy of another therapeutic agent.

As used herein, the term “therapy” refers to any protocol, method and/or agent that can be used in the prevention, management, treatment and/or amelioration of a given disease, disorder or condition. In certain embodiments, the terms “therapies” and “therapy” refer to a drug therapy, biological therapy, supportive therapy, and/or other therapies useful in the prevention, management, treatment and/or amelioration of a given disease, disorder or condition known to one of skill in the art such as medical personnel.

As used herein, and unless otherwise specified, the terms “treat,” “treating” and “treatment” refer to an action that occurs while a patient is suffering from the specified disease, disorder or condition. As used herein, the terms “treat,” “treatment” and “treating” refer to the reduction or amelioration of the progression, severity, and/or duration of a disease, disorder or condition resulting from the administration of one or more therapies.

“Tumor,” as used herein, refers to all neoplastic cell growth and proliferation, whether malignant or benign, and all pre-cancerous and cancerous cells and tissues. “Neoplastic,” as used herein, refers to any form of dysregulated or unregulated cell growth, whether malignant or benign, resulting in abnormal tissue growth. Thus, “neoplastic cells” include malignant and benign cells having dysregulated or unregulated cell growth.

An mRNA that is “upregulated” is generally increased upon a given treatment or condition. An mRNA that is “downregulated” generally refers to a decrease in the level of expression of the mRNA in response to a given treatment or condition. In some situations, the mRNA level can remain unchanged upon a given treatment or condition. An mRNA from a patient sample can be “upregulated” when treated with a drug, as compared to a non-treated control. This upregulation can be, for example, an increase of about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 90%, 100%, 200%, 300%, 500%, 1,000%, 5,000% or more of the comparative control mRNA level. Alternatively, an mRNA can be “downregulated”, or expressed at a lower level, in response to administration of certain compounds or other agents. A downregulated mRNA can be, for example, present at a level of about 99%, 95%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, 1% or less of the comparative control mRNA level. Similarly, the level of a polypeptide or protein biomarker from a patient sample can be increased when treated with a drug, as compared to a non-treated control. This increase can be about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 90%, 100%, 200%, 300%, 500%, 1,000%, 5,000% or more of the comparative control protein level. Alternatively, the level of a protein biomarker can be decreased in response to administration of certain compounds or other agents. This decrease can be, for example, present at a level of about 99%, 95%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, 1% or less of the comparative control protein level.

It should be noted that if there is a discrepancy between a depicted structure and a name given that structure, the depicted structure is to be accorded more weight. In addition, if the stereochemistry of a structure or a portion of a structure is not indicated with, for example, bold or dashed lines, the structure or portion of the structure is to be interpreted as encompassing all stereoisomers of it.

The practice of the embodiments provided herein will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology, and immunology, which are within the skill of those working in the art. Such techniques are explained fully in the literature. Examples of particularly suitable texts for consultation include the following: Sambrook et al. (1989) Molecular Cloning; A Laboratory Manual (2d ed.); D. N Glover, ed. (1985) DNA Cloning, Volumes I and II; M. J. Gait, ed. (1984) Oligonucleotide Synthesis; B. D. Hames & S J. Higgins, eds. (1984) Nucleic Acid Hybridization; B. D. Hames & S. J. Higgins, eds. (1984) Transcription and Translation; R. I. Freshney, ed. (1986) Animal Cell Culture; Immobilized Cells and Enzymes (IRL Press, 1986); Immunochemical Methods in Cell and Molecular Biology (Academic Press, London); Scopes (1987) Protein Purification: Principles and Practice (2d ed.; Springer Verlag, N.Y.); and D. M. Weir and C. C. Blackwell, eds. (1986) Handbook of Experimental Immunology, Volumes I-IV.

5.2 Methods of Identifying Compounds

Provided herein, for example, are compositions, methods and kits for screening or otherwise identifying a compound, that binds to an E3 ubiquitin ligase. In certain embodiments, the compound induces a conformational change in the E3 ubiquitin ligase ligand binding pocket. In other embodiments, the compound alters the properties of the E3 ubiquitin ligase surface. In some embodiments of the various compositions and methods provided herein, the compound alters the E3 ubiquitin ligase surface adjacent to the E3 ubiquitin ligase ligand binding pocket. In other embodiments, the compound alters one or more surrounding loops or other surface of the E3 ubiquitin ligase ligand binding pocket. In certain embodiments, the properties of the E3 ubiquitin ligase surface are altered by the placement of compound appendages. In a specific embodiment, the compound is a CMA. In another specific embodiment, the E3 ubiquitin ligase is CRBN.

While exemplary methods provided below and elsewhere refer to CRBN conformational changes (e.g., within the CMA binding pocket) or other alterations in the properties of a CRBN surface (e.g., on an adjacent region of the protein, such as a region adjacent to the CMA-binding pocket), it is understood that CRBN is merely illustrative and that the methods provided herein can be utilized with other E3 ubiquitin ligases.

In one aspect, provided herein is a method of identifying a test compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the method comprises (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. Also provided herein is a test compound identified by this method. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN.

In another aspect, provided herein is a method of identifying a test compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the method comprises (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. Also provided herein is a test compound identified by this method. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In another aspect, provided herein is a method of identifying a test compound that has a specific downstream biological activity comprising: (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound has the specific downstream biological activity. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. In some embodiments, the method further comprises assaying the specific biological activity. Also provided herein is a test compound identified by this method. In certain embodiments, the method further comprises administering said compound to a patient, wherein said biological activity is modulated in said patient. In certain embodiments, the patient has a disease, and wherein one or more symptoms of said disease are alleviated following said administration. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN.

In another aspect, provided herein is a method of identifying a test compound that has a specific downstream biological activity comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound has the specific downstream biological activity. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In some embodiments, the biological activity is a tumoricidal effect. In other embodiments, the biological activity is an apoptosis effect. In some embodiments, the biological activity is anti-proliferation. In yet other embodiments, the biological activity is PBMC viability. In some embodiments, the biological activity is toxicity. In certain embodiments, the biological activity is substrate degradation. In one embodiments, the biological activity is Aiolos degradation. In another embodiments, the biological activity is Ikaros degradation. In other embodiments, the biological activity is an immune-mediated effect. In another embodiment, the biological activity is IL-2 induction. In some embodiments, the biological activity is IL-2 repression. In yet other embodiments, the biological activity is a HbF effect. Any combination of one, two, three or more of the aforementioned biological activities is also contemplated. In certain embodiments, the biological activity is based on specific cell type categories. In other embodiments, the biological activity is based on specific tissue type categories. In yet other embodiments, the biological activity is based on solid tumors or solid tumor categories. In some embodiments, the biological activity is based on non-solid tumor categories.

In another aspect, provided herein is a method of identifying a test compound that has a specific therapeutic efficacy comprising: (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound has the specific therapeutic efficacy. In some embodiments, the first set of atomic coordinates and/or said second set of atomic coordinates define a CMA binding domain. In certain embodiments, the difference in atomic coordinates is determined by assessing differences in atomic distances. Also provided herein is a test compound identified by this method. In certain embodiments, the method further comprises administering said compound to a patient having disease, disorder or condition, wherein one or more symptoms of said disease, disorder or condition is alleviated following said administration. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN.

In another aspect, provided herein is a method of identifying a test compound that has a specific downstream therapeutic efficacy comprising: (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound has the specific downstream biological activity. Also provided herein is a test compound identified by this method. In some embodiments, the test compound induces a CRBN conformational change. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

5.2.1. Computer-Based Design of Compounds

Provided herein are methods of designing compounds based on fit within the CMA binding pocket of CRBN. In some embodiments, the methods are computer-based methods.

In one aspect, provided herein is a method of designing a test compound based on fit within CMA binding pocket of CRBN, comprising: (a) generating on a computer, three-dimensional structural features of a CRBN having a conformational change or alteration in the CMA binding pocket, (b) designing a test compound capable of selectively binding to said CMA binding pocket, (c) synthesizing said test compound, (d) contacting CRBN with said synthesized test compound, and (e) determining if said test compound binds to said CRBN. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN.

In one embodiment, the method comprises (i) generating (e.g., on a computer) a three-dimensional structural features of a CRBN having a conformational change or alteration in the CMA binding pocket, (ii) designing a compound capable of selectively binding to said CMA binding pocket, (iii) synthesizing said compound, (iv) contacting a CRBN with said synthesized compound, and (v) identifying a synthesized compound that binds to said CMA binding pocket. In certain embodiments, the CMA binding pocket conformational change or alteration of the CRBN is defined by atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7; or a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In some embodiments, the CMA binding pocket comprises W380, W386 and/or W400. Exemplary CMA binding pockets are provided in FIGS. 12-20 and 22; and Tables 3-5. In some embodiments, the method further comprises methods provided in Example 6.10.

In certain embodiments, the test compounds are synthesized and assayed for a biological activity as provided elsewhere herein. For example, in some embodiments, the biological activity is a tumoricidal effect, apoptosis effect, anti-proliferation, increased proliferation, PBMC viability, toxicity, substrate degradation (e.g., Aiolos or Ikaros degradation), an immune-mediated effect, IL-2 induction, or IL-2 repression.

In other embodiments, the test compounds are synthesized and assayed for a therapeutic activity as provided elsewhere herein.

5.3 Crystalline CRBN

Provided herein are crystalline forms of CRBN, for example, unbound CRBN or CRBN complexed with a CMA. In one embodiment, the crystalline form has atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7. In some embodiments, the crystalline form has a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, the CRBN is complexed with (or otherwise bound to) DDB1. In other embodiments, the CRBN is complexed with (or otherwise bound to) a CMA. In certain embodiments, the CMA is thalidomide, pomalidomide or lenalidomide. In other embodiments, the CRBN is complexed with (or otherwise bound to) DDB1 and a CMA. Exemplary crystals and methods of making the crystals are provided in Example 6.10 below.

5.3.1. Crystalline CRBN—Unbound

Provided herein is a crystalline CRBN. In certain embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In one embodiment, the CRBN has a three-dimensional structure. In certain embodiments, the three-dimensional structure is determined by x-ray diffraction. In a specific embodiment, the three-dimensional structure has the following atomic coordinates. In one embodiment, the crystalline form has atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7. In some embodiments, the crystalline form has a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, the CRBN is complexed with (or otherwise bound to) DDB1. In other embodiments, the CRBN is complexed with (or otherwise bound to) a CMA. In certain embodiments, the CMA is thalidomide, pomalidomide or lenalidomide. In other embodiments, the CRBN is complexed with (or otherwise bound to) DDB and a CMA. Exemplary crystals and methods of making the crystals are provided in Example 6.10 below.

In a specific embodiment, the crystalline form has atomic coordinates set forth in Table 4. In other embodiments, the crystalline form has atomic coordinates set forth in Table 5. In other embodiments, the crystalline form has atomic coordinates set forth in Table 6. In other embodiments, the crystalline form has atomic coordinates set forth in Table 7.

In some embodiments, the crystalline form comprises a fragment of CRBN. In other embodiments, the crystalline form comprises a fragment of CRBN, either alone or in combination with DDB1 and/or a CMA provided herein.

Also provided herein is a method to obtain a crystalline CRBN, wherein said method comprises concentrating the CRBN and obtaining a crystal using methods provided in Example 6.10 below.

5.3.2. Crystalline CRBN—Bound

Provided herein is a crystal of a complex comprising CRBN and a CMA. In one embodiment, the CMA is an immunomodulatory compound provided herein (see, e.g., Section 5.9 below). In other embodiments, the CMA is Compound C or an analog thereof. In certain embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In one embodiment, the crystal of the complex has a three-dimensional structure. In certain embodiments, the three-dimensional structure is determined by x-ray diffraction. In one embodiment, the crystal has atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7. In some embodiments, the crystal has a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, the CRBN is complexed with (or otherwise bound to) DDB1. In other embodiments, the CRBN is complexed with (or otherwise bound to) a CMA. In certain embodiments, the CMA is thalidomide, pomalidomide or lenalidomide. In other embodiments, the CRBN is complexed with (or otherwise bound to) DDB and a CMA. Exemplary crystals and methods of making the crystals are provided in Example 6.10 below.

In one embodiment, the crystal has atomic coordinates set forth in Table 3. In a specific embodiment, the crystal has atomic coordinates set forth in Table 4. In other embodiments, the crystal has atomic coordinates set forth in Table 5. In other embodiments, the crystal has atomic coordinates set forth in Table 6. In other embodiments, the crystal has atomic coordinates set forth in Table 7.

Generally speaking, those of skill in the art will understand that the term “coordinates” or “structure coordinates” refers to Cartesian coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of a polypeptide in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are then used to estimate the positions of the individual atoms of the polypeptide to construct a polypeptide model. Those of skill in the art will also understand that a set of structure coordinates for a polypeptide model is a relative set of points that define a structure in three dimensions.

Those of skill in the art understand that a set of structure coordinates determined by X-ray crystallography is approximate and not without standard error. Due to inherent limitations of the resolution of diffraction data, the positions of individual atoms in a polypeptide model are necessarily approximate. Slight variations in atomic position within a polypeptide model will have little effect on overall shape and structure of the polypeptide model. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape and structure is considered to be structurally equivalent. By way of example, those skilled in the art understand that a set of structure coordinates for a given polypeptide model having a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of a second set of structure coordinates for a second polypeptide model are typically considered to be substantially identical or homologous.

It also is possible that an entirely different set of coordinates could define a similar or identical shape. Slight variations in structure coordinates also can be generated by mathematically manipulating the coordinates of a polypeptide model. For example, the structure coordinates set forth herein could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates, or any combination thereof. Alternatively, modification in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal, could also account for variations in structure coordinates. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be the same as that of the unmodified crystal structure.

In some embodiments, the crystal comprises a fragment of CRBN. In other embodiments, the crystal comprises a fragment of CRBN, either alone or in combination with DDB1 and/or a CMA provided herein.

In certain embodiments, the three-dimensional structure is indicative of a conformational change or alteration in the CRBN. In some embodiments, the CRBN conformational change or alteration is as compared to an unbound CRBN. In other embodiments, the CRBN conformational change or alteration is as compared to complex comprising the CRBN and an analog of the CMA. In yet other embodiments, the CRBN conformational change or alteration is as compared to a complex comprising CRBN and a different CMA.

Also provided herein is a crystal of a complex comprising CRBN and a CMA, or an analog thereof. Also provided herein is a method of obtaining the crystal, comprising concentrating a purified complex of the CRBN and the CMA, or analog thereof, and obtaining the crystal. In certain embodiments, the method further comprises methods provided in Example 6.10 below.

Also provided herein is a crystal of a complex comprising CRBN and a compound, wherein said crystal has a three-dimensional structure as determined by x-ray diffraction having the following atomic coordinates. In one embodiment, the crystal has atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7. In some embodiments, the crystal has a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, the CRBN is complexed with (or otherwise bound to) DDB1. In other embodiments, the CRBN is complexed with (or otherwise bound to) a CMA. In certain embodiments, the CMA is thalidomide, pomalidomide or lenalidomide. In other embodiments, the CRBN is complexed with (or otherwise bound to) DDB and a CMA. Exemplary crystals and methods of making the crystals are provided in Example 6.10 below.

In one embodiment, the crystal has atomic coordinates set forth in Table 3. In a specific embodiment, the crystal has atomic coordinates set forth in Table 4. In other embodiments, the crystal has atomic coordinates set forth in Table 5. In other embodiments, the crystal has atomic coordinates set forth in Table 6. In other embodiments, the crystal has atomic coordinates set forth in Table 7.

In some embodiments, the crystal comprises a fragment of CRBN. In other embodiments, the crystal comprises a fragment of CRBN, either alone or in combination with DDB1 and/or a CMA provided herein.

Also provided herein is a crystal of a complex comprising a CRBN and a compound, wherein said crystal has a three-dimensional structure as determined by x-ray diffraction, wherein said three-dimensional structure has atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7 indicative of CRBN conformational change or alteration. In some embodiments, the CRBN conformational change or alteration is as compared to a complex comprising CRBN and reference compound. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN.

In certain embodiments of the various compositions and methods provided herein, the CRBN is bound to DDB1. In some embodiments, the CRBN is bound to Cul4. In other embodiments, the CRBN is bound to Roc1. In some embodiments, the CRBN is bound to DDB1 and Cul4. In other embodiments, the CRBN is bound to DDB1 and Roc1. In yet other embodiments, the CRBN is bound to Cul4 and Roc1. In some embodiments, the CRBN is bound to DDB1, Cul4 and Roc1. In certain embodiments, CRBN that is bound to DDB1, Cul4 and/or Roc1 is a complex with DDB1, Cul4 and/or Roc1, respectively.

In some embodiments of the various compositions and methods provided herein, the CMA is an immunomodulatory compound provided herein (see, e.g., Section 5.9 below). In certain embodiments, the CMA is thalidomide. In other embodiments, the CMA is pomalidomide. In some embodiments, the CMA is Compound B. In other embodiments, the CMA is Compound C. In certain embodiments, the CMA is a thalidomide analog. In other embodiments, the CMA is a pomalidomide analog. In some embodiments, the CMA is a Compound B analog. In other embodiments, the CMA is a Compound C analog. In other embodiments, the CMA is not thalidomide. In other embodiments, the CMA is not pomalidomide. In some embodiments, the CMA is not Compound B. In other embodiments, the CMA is not Compound C. In other embodiments, the CMA is not a thalidomide analog. In other embodiments, the CMA is not a pomalidomide analog. In some embodiments, the CMA is not a Compound B analog. In other embodiments, the CMA is not a Compound C analog.

Also provided herein are methods of identifying a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein) comprising: (i) obtaining a crystal comprising a complex comprising the CRBN and the compound, (ii) determining the three-dimensional structure of the crystal by x-ray diffraction to obtain atomic coordinates, and (iii) comparing said atomic coordinates with atomic coordinates provided in any one of Tables 3, 4, 5, 6 or 7, wherein a change or shift in atomic coordinates is indicative of a compound that induces said CRBN conformational change or alteration. In certain embodiments, the atomic coordinates define the CMA binding domain. Also provided herein are compounds identified by these methods. In some embodiments, the test compound induces a CRBN conformational change or alteration. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein.

5.4 Methods of Inducing a CRBN Conformational Change or Alteration

Provided herein are methods of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), said method comprising contacting the CRBN with a CMA.

In certain embodiments, a conformational change in the CMA-binding pocket is induced. In other embodiments, an alteration in the properties of the CRBN surface is induced. In some embodiments, a CRBN surface adjacent to the CMA-binding pocket is altered. In other embodiments, one or more surrounding loops that are adjacent or otherwise surround the CMA binding pocket are altered. In certain embodiments, the properties of the CRBN surface are altered by the placement of a compound's appendages. In a specific embodiment, the compound is a CMA.

In some embodiments, the CRBN conformational change results in an altered substrate specificity, biological activity and/or therapeutic utility as compared to CRBN in the absence of the CMA. In some embodiments, the CRBN conformational change results in an altered substrate specificity, biological activity and/or therapeutic utility as compared to CRBN in the presence of a different CMA. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced.

Provided herein, in certain embodiments, is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a test compound, wherein said CRBN conformational change or alteration comprises a conformational change or alteration within the CMA binding pocket of the CRBN that is different than the conformational change or alteration within the CMA binding pocket of a CRBN contacted with a reference compound. In some embodiments, the CRBN conformational change or alteration results in a different biological activity. In some embodiments, the CRBN conformational change or alteration results in a different therapeutic utility. In other embodiments, the CRBN conformational change or alteration results in a different substrate specificity. In some embodiments, the test compound induces a CRBN conformational change or alteration. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

Also provided herein is a composition comprising a CRBN and a test compound, wherein said CRBN has a conformational change or alteration as compared to a reference compound. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

Also provided herein is a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein) upon contact with said CRBN, as compared to the conformational change or alteration as compared to a reference compound. In some embodiments, the CRBN conformational change or alteration results in a different biological activity. In some embodiments, the CRBN conformational change or alteration results in a different therapeutic utility. In other embodiments, the CRBN conformational change or alteration results in a different substrate specificity. In some embodiments, the compound induces a CRBN conformational change or alteration. In other embodiments, the compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

Also provided herein is a complex comprising a CRBN and test compound, wherein said CRBN has a conformational change or alteration as compared to a conformational change or alteration of said CRBN contacted with a reference compound. In some embodiments, the CRBN has a conformational change or alteration. In other embodiments, the CRBN has an alteration of the properties of the CRBN surface. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In various embodiments of the methods provided herein, the compound is a compound provided herein (see, e.g., Section 5.9 below). In other embodiments, the compound is not a compound provided herein. In various embodiments of the methods provided herein, the compound is a CMA. In certain embodiments, the CMA is thalidomide, lenalidomide, pomalidomide, 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (Compound A) or 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In certain embodiments of the methods provided herein, the CMA is not thalidomide, lenalidomide, pomalidomide, 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (Compound A) or 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (Compound B), a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In an embodiment, the compound is lenalidomide. In another embodiment, the compound is Compound A. In some embodiments, the compound is not thalidomide. In other embodiments, the compound is not lenalidomide. In other embodiments, the compound is not Compound A. In some embodiments, the compound is not thalidomide, lenalidomide, Compound A, or any analog thereof.

In certain embodiments of the various compositions and methods provided herein, the substrate is a CRBN-associated protein.

In some embodiments, the CRBN-associated protein is Ikaros. In other embodiments, the CRBN-associated protein is Aiolos. In some embodiments, the CRBN-associated protein is Ikaros and Aiolos. In certain embodiments, the CRBN-associated protein is interferon. In other embodiments, the CRBN-associated protein is an interferon pathway protein. In some embodiments, the interferon pathway protein is interferon-induced transmembrane protein 3 (IFITM3) and/or interferon regulatory factor 7 (IRF7). In one embodiment of the methods provided herein, the CRBN-associated protein is IKZF3 (Aiolos) having a molecular weight of 58 kDa. In another embodiment of the methods provided herein, the CRBN-associated protein is IKZF3 (Aiolos) having a molecular weight of 42 kDa. Other isoforms of Ikaros and/or Aiolos are also contemplated herein. In various embodiments of the methods provided herein, the CRBN-associated protein is interferon, an interferon pathway protein, casein kinase 1, alpha 1 (CSNK1A1), or a combination thereof. In other embodiments, the CRBN-associated protein is DDB1, DDB2, GSK3B, CUL4A, CUL4B, XBP-1, FAS1, RANBP6, DUS3L, PHGDH, AMPK, IRF4 or NFκB. In various embodiments of the methods provided herein, the CRBN-associated protein is DDB1, PABPC1, HNRNPR, RPL19, SYNCRIP, H2AFX, HSPA8, ALDOA, HIST1H2AA, HSPA1A, XRCC6, RPL12, RPL18A, RPL4, HNRNPA2B1, HNRNPC, RPS2, SEC24C, RPL9, USP15, SEC24A, CTPS, ABCE1, EEF1A1, IPO5, CPSF6, KCNAB2, C7ORF42, SMC4, GNB3, H2AFZ, HIST1H1C, HIST1H1D, HIST1H1E, ACTB, CSNK2A1, CRBN, DDX21, DHX9, DNAJC1, G3BP1, HSPA1B, IGF2BP2, RPL10A, RPL13A, RPL14, RPL15, RPL21, RPL3, RPL30, RPL7, RPL7A, RPLP1, RPLP2, MYH10, ILF3, NCL, RPS13, RPS16, RPS19, RPS6, SND1, EIF2S2, HNRNPH2, UBB, EEF1G, TBL1XR1, NACA, EIF4A1, FASN, PPAT, G3BP2, TUBA1A, UBAP2L, MCM2, UAP1, TUBA1C, EIF2S1, EIF3J, PRKDC, MCM7, RPL11, TUBA1B, STAT3, PTRH2, PABPC4, PTPRC, MACF1, UBE2O, DUT, GNB2L1, NUP88, H2AFJ, SEC23B, PDXK, ACLY, ARID1A, GBE1, HSPA9, DDX17, FUBP1, FBXO21, EWSR1, IFI16, YWHAE, UBA52, COPSE, GNAS, UBE2Q1, FERMT3, NAP1L2, TPD52, VAPA, EEF1AL3, DDIT4, NEDD8, HIST1H1A, HIST1H1B, or PCM1. Other isoforms of the aforementioned CRBN-associated proteins are also contemplated herein.

In various embodiments of the methods provided herein, the CRBN-associated protein is GSPT1, GSPT2, HBS1L, IKZF1, IKZF3, CK1a, eRF1, BIP, PERK, GCN2, eIF2a, ATF4, ATF3, DDIT3, PPP1R15A, TNFRSF10B, GADD45A, TNFRSF1A, TNFRSF1B, FAS, FADD, IRE1, XBP1, SEC24D, DNAJB9, EDEM1, EDEM2, HYOU1, ATF6, HSPA5, Caspase 3, Caspase 7, Caspase 8, BID, Caspase 9, PARP, Mcl-1, and BAD. In a particular embodiment, the CAP is GSPT1. In another embodiment, the CAP is IKZF1. In yet another embodiment, the CAP is CK1a.

5.4.1. Inducing a CRBN Conformational Change to Alter Substrate Specificity

Also provided herein are methods of inducing a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), said method comprising contacting the CRBN with a CMA, wherein said CRBN conformational change or alteration results in an altered substrate specificity. In certain embodiments, the altered substrate specificity is as compared to a CRBN in the absence of the CMA. In other embodiments, the altered substrate specificity is as compared to a CRBN in the presence of a different CMA. In some embodiments, a CRBN conformational change or alteration is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced.

In one aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a test compound, wherein said CRBN conformational change or alteration results in a different substrate specificity as compared to the substrate specificity of a CRBN that is contacted with a reference compound. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

Substrate specificity can be assessed using any method known to those in the art. In some embodiments, substrate specificity is assessed using UbiScan. In other embodiments, substrate specificity is assessed by quantitating the level of a protein or mRNA of a CRBN-associated protein as provided elsewhere herein.

5.4.2. Inducing a CRBN Conformational Change to Modulate a Biological Activity or Therapeutic Efficacy

In some embodiments, CRBN conformational changes (e.g., within the CMA-binding pocket of the CRBN) or an alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) following contact with a CMA results in an altered substrate specificity, wherein the altered substrate specificity, in turn, modulates downstream biological activity.

Provided herein are methods of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), said method comprising contacting the CRBN with a CMA, wherein said CRBN conformational change or alteration results in modulation of a biological activity in a cell or subject. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced.

In some embodiments, the conformational change or alteration occurs within the CMA binding pocket of the CRBN. In certain embodiments, the conformational change or alteration is assessed using any one of the methods provided herein. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein.

In another aspect, provided herein is a method of identifying a test compound that induces a specific biological activity, comprising contacting the test compound with CRBN, inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), and assessing conformational change or alteration within the CMA-binding pocket of the CRBN, wherein conformational change or alteration is indicative of a specific biological activity. In some embodiments, the method further comprises assaying the specific biological activity. Also provided herein is a test compound identified by this method. In certain embodiments, the method further comprises administering said compound to a patient, wherein said biological activity is modulated in said patient. In certain embodiments, the patient has a disease, and wherein one or more symptoms of said disease are alleviated following said administration. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the test compound induces a CRBN conformational change or alteration. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In some embodiments, the biological activity is a tumoricidal effect. In one embodiment, the biological activity is modulation of apoptosis. In other embodiment, the biological activity is modulation of proliferation, e.g., an anti-proliferative effect. In some embodiments, the biological activity is modulation of PBMC viability. In certain embodiments, the biological activity is modulation of toxicity. In other embodiments, the biological activity is substrate degradation. In certain embodiments, the biological activity is degradation of Aiolos and/or Ikaros. In certain embodiments, the biological activity is a prevention of substrate degradation. In some embodiments, the substrate is a CRBN-associated protein. In some embodiments, the biological activity is an immune-mediated effect. In certain embodiments, the biological effect is modulation of IL-2. In yet other embodiments, the biological effect is an effect on fetal hemoglobin (HbF). In some embodiments, the effect is an effect on a CRBN-associated protein.

In certain embodiments, a biological activity is observed in one cell type, but not another cell type. In a specific embodiments, the biological activity is directly correlated with an observed CRBN conformational shift in the cell type(s). In an embodiments, the CRBN conformational shift is in a CMA-binding pocket of CRBN. Such conformational shifts can be assessed using any of the various methods provided elsewhere herein.

In some embodiments, a biological activity is observed in one tissue type, but not another tissue type. In a specific embodiments, the biological activity is directly correlated with an observed CRBN conformational shift in the tissue type(s). In an embodiments, the CRBN conformational shift is in a CMA-binding pocket of CRBN. Such conformational shifts can be assessed using any of the various methods provided elsewhere herein.

In certain embodiments, a biological activity is observed in one tumor (or cancer) type, but not another tumor (or cancer) type. In a specific embodiments, the biological activity is directly correlated with an observed CRBN conformational shift in the tumor (cancer) type(s). In an embodiments, the CRBN conformational shift is in a CMA-binding pocket of CRBN. Such conformational shifts can be assessed using any of the various methods provided elsewhere herein.

In some embodiments, a biological activity is observed in a solid tumor (or cancer), but not in a non-solid tumor (or cancer) (e.g., a hematological tumor). In a specific embodiments, the biological activity is directly correlated with an observed CRBN conformational shift in the tumor(s) (or cancer(s)). In an embodiments, the CRBN conformational shift is in a CMA-binding pocket of CRBN. Such conformational shifts can be assessed using any of the various methods provided elsewhere herein.

In some embodiments, a biological activity is observed in a non-solid tumor (or cancer) (e.g., a hematological tumor), but not in a solid tumor (or cancer). In a specific embodiments, the biological activity is directly correlated with an observed CRBN conformational shift in the tumor(s) (or cancer(s)). In an embodiments, the CRBN conformational shift is in a CMA-binding pocket of CRBN. Such conformational shifts can be assessed using any of the various methods provided elsewhere herein.

In certain embodiments, the solid tumor or cancer is a breast, kidney, ovary, colon, bladder, brain, liver of prostate tumor or cancer. In some embodiments, the non-solid tumor is a blood (hematological) cancer.

In some embodiments, exemplary tumors or cancers include without limitation acute lymphoblastic leukemia, acute myeloid leukemia, Ewing's sarcoma, gestational trophoblastic carcinoma, Hodgkin's disease, non-Hodgkin's lymphoma, Burkitt's lymphoma diffuse large cell lymphoma, follicular mixed lymphoma, lymphoblastic lymphoma, rhabdomyosarcoma, testicular carcinoma, wilms's tumor, anal carcinoma, bladder carcinoma, breast carcinoma, chronic lymphocytic leukemia, chronic myelogenous leukemia, hairy cell leukemia, head and neck carcinoma, meningioma, neuro fibrosoma, angio fibrosoma, lung (small cell) carcinoma, multiple myeloma, Non-Hodgkin's lymphoma, follicular lymphoma, ovarian carcinoma, brain tumors (astrocytoma), cervical carcinoma, colorectal carcinoma, hepatocellular carcinoma, human large hepatocellular carcinoma, Kaposi's sarcoma, lung (non-small-cell) carcinoma, melanoma, pancreatic carcinoma, prostate carcinoma, soft tissue sarcoma, breast carcinoma, colorectal carcinoma (stage II), bone tumors, osteogenic sarcoma, ovarian carcinoma, uterine fibroids, testicular carcinoma, or combinations thereof.

In one aspect, provided herein is a method of inducing a biological activity in a cell comprising CRBN, comprising contacting said cell with a test compound, wherein said compound induces a conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein) of said CRBN, and wherein said CRBN conformational change or alteration is as compared to a reference compound, and wherein the conformational change or alteration results in said biological activity. In some embodiments, a CRBN conformational change or alteration is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In some embodiments, the biological activity is a tumoricidal effect. In other embodiments, the biological activity is an apoptosis effect. In some embodiments, the biological activity is anti-proliferation. In yet other embodiments, the biological activity is PBMC viability. In some embodiments, the biological activity is toxicity. In certain embodiments, the biological activity is substrate degradation. In one embodiments, the biological activity is Aiolos degradation. In another embodiments, the biological activity is Ikaros degradation. In other embodiments, the biological activity is an immune-mediated effect. In another embodiment, the biological activity is IL-2 induction. In some embodiments, the biological activity is IL-2 repression. In yet other embodiments, the biological activity is a HbF effect. Any combination of one, two, three or more of the aforementioned biological activities is also contemplated. In certain embodiments, the biological activity is based on specific cell type categories. In other embodiments, the biological activity is based on specific tissue type categories. In yet other embodiments, the biological activity is based on solid tumors or solid tumor categories. In some embodiments, the biological activity is based on non-solid tumor categories. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In some embodiments, the reference compound is an immunomodulatory compound provided herein.

In certain embodiments, the biological activity being modulated by the CMA has a direct effect on therapeutic utility of the CMA in a subject.

In one aspect, provided herein is a method of inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface (e.g., on an adjacent region of the protein), comprising contacting the CRBN with a compound, wherein said CRBN conformational change or alteration results in a specific therapeutic utility. In some embodiments, a CRBN conformational change or alteration is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In some embodiments, the therapeutic utility is based on solid tumors or solid tumor categories. In other embodiments, the therapeutic utility is based on non-solid tumor categories. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In another aspect, provided herein is a method of identifying a test compound that has a specific therapeutic utility, comprising contacting the test compound with CRBN, inducing a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise altering the properties of a CRBN surface (e.g., on an adjacent region of the protein), and assessing the conformational change or alteration within the CMA-binding pocket of the CRBN, wherein a conformational change or alteration is indicative of the specific therapeutic utility. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. Also provided herein is a test compound identified by this method. In some embodiments, the method further comprises administering said compound to a patient having a disease, wherein one or more symptoms of said disease is alleviated following said administration. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In certain embodiments of the methods provided herein, the contacting in step (a) is performed in vitro. In other embodiments, the contacting in step (a) is performed in vivo. In one embodiment, the CRBN is are contacted with the compound for a period of time, e.g., 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, or 55 minutes, or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24 hours, or 2 or 3 or more days.

In some embodiments of the various methods provided herein, the therapeutic utility is the management or treatment of a CRBN-associated disease, disorder or a symptom thereof. In other embodiments, the therapeutic utility is the management or treatment of a cancer or tumor, or a symptom thereof. In some embodiments, the tumor or cancer is a liver cancer, kidney cancer, acute lymphoblastic leukemia, acute myeloid leukemia, Ewing's sarcoma, gestational trophoblastic carcinoma, Hodgkin's disease, non-Hodgkin's lymphoma, Burkitt's lymphoma diffuse large cell lymphoma, follicular mixed lymphoma, lymphoblastic lymphoma, rhabdomyosarcoma, testicular carcinoma, wilms's tumor, anal carcinoma, bladder carcinoma, breast carcinoma, chronic lymphocytic leukemia, chronic myelogenous leukemia, hairy cell leukemia, head and neck carcinoma, meningioma, neuro fibrosoma, angio fibrosoma, lung (small cell) carcinoma, multiple myeloma, Non-Hodgkin's lymphoma, follicular lymphoma, ovarian carcinoma, brain tumors (astrocytoma), cervical carcinoma, colorectal carcinoma, hepatocellular carcinoma, human large hepatocellular carcinoma, Kaposi's sarcoma, lung (non-small-cell) carcinoma, melanoma, pancreatic carcinoma, prostate carcinoma, soft tissue sarcoma, breast carcinoma, colorectal carcinoma (stage II), bone tumors, osteogenic sarcoma, ovarian carcinoma, uterine fibroids, testicular carcinoma, or combinations thereof. In some embodiments, the cancer or tumor is a lymphoma, leukemia, multiple myeloma, solid tumor, non-Hodgkin's lymphoma, DLBCL, mantle cell lymphoma, follicular lymphoma, acute myeloblastic leukemia, chronic lymphocytic leukemia, MDS or melanoma.

In another aspect, provided herein is a method of treating or alleviating one or more symptoms of a CRBN-mediated disease or disorder in a patient, comprising administering a test compound to the subject, wherein said compound induces a conformational change or alteration of said CRBN, and wherein said CRBN conformational change or alteration is as compared to a reference compound, and wherein said CRBN conformational change or alteration results in treatment or alleviation of one or more symptoms of said disease or disorder. In certain embodiments, the disease or disorder is a cancer or tumor. In some embodiments, the test compound induces a CRBN conformational change or alteration. In other embodiments, the test compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof. In some embodiments provided herein is a (test) compound for use in a method of treating or alleviating one or more symptoms of a CRBN-mediated disease or disorder in a patient, wherein the method comprises administering the (test) compound to a patient, wherein said compound is as described above.

Also provided herein is a method of alleviating one or more symptoms of a CRBN-associated disease, disorder, or a symptom thereof, in a patient, comprising administering a compound to the subject, wherein said compound induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein) in a cell of said subject. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In some embodiments, the CRBN conformational change or alteration is assessed using a method provided elsewhere herein. In certain embodiments, the CRBN conformational change or alteration comprises atomic coordinates as provided in any one of Tables 3-5, or FIG. 12-18 or 20. In some embodiments, the CRBN conformational change or alteration results in alleviation of one or more symptoms of said CRBN-mediated disease or disorder in the patient. In some embodiments provided herein is a compound for use in a method of alleviating one or more symptoms of a CRBN-associated disease, disorder, or a symptom thereof, in a patient, the method comprises administering a compound to the subject.

In some embodiments of the various methods provided herein, the CRBN-associated disease or disorder is a cancer or tumor. In other embodiments, the CRBN-associated disease or disorder is not a cancer or tumor. In some embodiments, the tumor or cancer is a liver cancer, kidney cancer, acute lymphoblastic leukemia, acute myeloid leukemia, Ewing's sarcoma, gestational trophoblastic carcinoma, Hodgkin's disease, non-Hodgkin's lymphoma, Burkitt's lymphoma diffuse large cell lymphoma, follicular mixed lymphoma, lymphoblastic lymphoma, rhabdomyosarcoma, testicular carcinoma, wilms's tumor, anal carcinoma, bladder carcinoma, breast carcinoma, chronic lymphocytic leukemia, chronic myelogenous leukemia, hairy cell leukemia, head and neck carcinoma, meningioma, neuro fibrosoma, angio fibrosoma, lung (small cell) carcinoma, multiple myeloma, Non-Hodgkin's lymphoma, follicular lymphoma, ovarian carcinoma, brain tumors (astrocytoma), cervical carcinoma, colorectal carcinoma, hepatocellular carcinoma, human large hepatocellular carcinoma, Kaposi's sarcoma, lung (non-small-cell) carcinoma, melanoma, pancreatic carcinoma, prostate carcinoma, soft tissue sarcoma, breast carcinoma, colorectal carcinoma (stage II), bone tumors, osteogenic sarcoma, ovarian carcinoma, uterine fibroids, testicular carcinoma, or combinations thereof. In some embodiments, the cancer or tumor is a lymphoma, leukemia, multiple myeloma, solid tumor, non-Hodgkin's lymphoma, DLBCL, mantle cell lymphoma, follicular lymphoma, acute myeloblastic leukemia, chronic lymphocytic leukemia, MDS or melanoma.

5.4.3. Methods of Assaying a Specific Biological Activity

In certain embodiments of the methods provided herein, the method comprises assaying a specific biological activity. In certain embodiments, the biological activity is substrate degradation. In certain embodiments, the substrate is a CRBN-associated protein. In some embodiments, the CRBN-associated protein is detected and/or quantified. In some embodiments, the methods comprises: (a) contacting the sample with a first antibody that immunospecifically binds to the CRBN-associated protein; (b) contacting the sample bound to the first antibody with a second antibody with a detectable label, wherein the second antibody immunospecifically binds to the CRBN-associated protein, and wherein the second antibody immunospecifically binds to a different epitope on CRBN-associated protein than the first antibody; (c) detecting the presence of second antibody bound to the sample; and (d) determining the protein level of the CRBN-associated protein based on the amount of detectable label in the second antibody. In one embodiment, the CRBN-associated protein is Ikaros. In another embodiment, the CRBN-associated protein is Aiolos. In yet another embodiment, the CRBN-associated protein is Ikaros and Aiolos. In yet other embodiments, the CRBN-associated protein is interferon. In other embodiments, the CRBN-associated protein is an interferon pathway protein. In other embodiments, the interferon pathway protein is interferon-induced transmembrane protein 3 (IFITM3) and/or interferon regulatory factor 7 (IRF7). In yet other embodiments, the CRBN-associated protein is casein kinase 1, alpha 1 (CSNK1A1).

In other embodiments, the method comprises: (a) obtaining RNA from the sample; (b) contacting the RNA with a primer comprising a sequence specifically binding to a sequence in the RNA to generate a first DNA molecule having a sequence complementary to said RNA; (c) amplifying the DNA corresponding to a segment of a gene encoding the CRBN-associated protein; and (d) determining the RNA level of the CRBN-associated protein based on the amount of the amplified DNA. In one embodiment, the CRBN-associated protein is Ikaros. In another embodiment, the CRBN-associated protein is Aiolos. In yet another embodiment, the CRBN-associated protein is Ikaros and Aiolos. In yet other embodiments, the CRBN-associated protein is interferon. In other embodiments, the CRBN-associated protein is an interferon pathway protein. In other embodiments, the interferon pathway protein is interferon-induced transmembrane protein 3 (IFITM3) and/or interferon regulatory factor 7 (IRF7). In yet other embodiments, the CRBN-associated protein is casein kinase 1, alpha 1 (CSNK1A1).

In certain embodiments, the CRBN-associated protein is DDB1, DDB2, GSK3B, CUL4A, CUL4B, XBP-1, FAS1, RANBP6, DUS3L, PHGDH, AMPK, IRF4 or NFκB. In certain embodiments, the CRBN-associated protein is DDB1, PABPC1, HNRNPR, RPL19, SYNCRIP, H2AFX, HSPA8, ALDOA, HIST1H2AA, HSPA1A, XRCC6, RPL12, RPL18A, RPL4, HNRNPA2B1, HNRNPC, RPS2, SEC24C, RPL9, USP15, SEC24A, CTPS, ABCE1, EEF1A1, IPO5, CPSF6, KCNAB2, C7ORF42, SMC4, GNB3, H2AFZ, HIST1H1C, HIST1H1D, HIST1H1E, ACTB, CSNK2A1, CRBN, DDX21, DHX9, DNAJC1, G3BP1, HSPA1B, IGF2BP2, RPL10A, RPL13A, RPL14, RPL15, RPL21, RPL3, RPL30, RPL7, RPL7A, RPLP1, RPLP2, MYH10, ILF3, NCL, RPS13, RPS16, RPS19, RPS6, SND1, EIF2S2, HNRNPH2, UBB, EEF1G, TBL1XR1, NACA, EIF4A1, FASN, PPAT, G3BP2, TUBA1A, UBAP2L, MCM2, UAP1, TUBA1C, EIF2S1, EIF3J, PRKDC, MCM7, RPL11, TUBA1B, STAT3, PTRH2, PABPC4, PTPRC, MACF1, UBE2O, DUT, GNB2L1, NUP88, H2AFJ, SEC23B, PDXK, ACLY, ARID1A, GBE1, HSPA9, DDX17, FUBP1, FBXO21, EWSR1, IFI16, YWHAE, UBA52, COPSE, GNAS, UBE2Q1, FERMT3, NAP1L2, TPD52, VAPA, EEF1AL3, DDIT4, NEDD8, HIST1H1A, HIST1H1B, PCM1. In some embodiments, these CRBN-associated proteins are evaluated in combination with other CRBN-associated proteins provided herein, such as Ikaros, Aiolos, interferon, an interferon pathway protein, and/or casein kinase 1, alpha 1.

In various embodiments of the methods provided herein, the CRBN-associated protein is GSPT1, GSPT2, HBS1L, IKZF1, IKZF3, CK1a, eRF1, BIP, PERK, GCN2, eIF2a, ATF4, ATF3, DDIT3, PPP1R15A, TNFRSF10B, GADD45A, TNFRSF1A, TNFRSF1B, FAS, FADD, IRE1, XBP1, SEC24D, DNAJB9, EDEM1, EDEM2, HYOU1, ATF6, HSPA5, Caspase 3, Caspase 7, Caspase 8, BID, Caspase 9, PARP, Mcl-1, and BAD. In a particular embodiment, the CAP is GSPT1. In another embodiment, the CAP is IKZF1. In yet another embodiment, the CAP is CK1a.

In certain embodiments of the various methods provided herein, the two or more of the steps are performed sequentially. In other embodiments of the methods provided herein, two or more of steps are performed in parallel (e.g., at the same time).

Exemplary assays provided herein for the methods of detecting and quantifying the protein level of CRBN-associated protein are immunoassays such as western blot analysis, and an enzyme-linked immunosorbent assay (ELISA) (e.g., a sandwich ELISA). An exemplary assay provided herein for the methods of detecting and quantifying the RNA level of a CRBN-associated protein is reverse transcription polymerase chain reaction (RT-PCR), e.g., quantitative PCR or qPCR.

5.4.4. Types of Cells

In certain embodiments, the biological activity is based on specific cell type categories. Such cells can include any type of cells, e.g., stem cells, blood cells (e.g., peripheral blood mononuclear cells), lymphocytes, B cells, T cells, monocytes, granulocytes, immune cells, or tumor or cancer cells.

For example, B cells (B lymphocytes) include plasma B cells, memory B cells, B1 cells, B2 cells, marginal-zone B cells, and follicular B cells. B cells can express immunoglobulins (antibodies, B cell receptor). In one embodiment, the cells are Karpas 422, TMD8, WSU-DLCL2, OCI-LY10, Karpas 1106P, HT, SUDHL-10, Riva, OCI-LY19, SUDHL-4, SUDHL-6, OCI-LY3, and Farage.

Specific cell populations can be obtained or assessed using a combination of commercially available antibodies (e.g., Quest Diagnostic (San Juan Capistrano, Calif.); Dako (Denmark)).

In certain embodiments, the cell line is lenalidomide-resistant WSU-DLCL2 or TMD8 cell line. In certain embodiments, the cell line is a DLBCL cell line. In some embodiments, the cell line is a ABC-DLBCL (activated B cell-like DLBCL) cell line, for example, TMD8, OCI-LY10, Riva, or OCI-LY3 cell line. In other embodiments, the cell line is a GCB-DLBCL (germinal center B cell-like DLBCL) cell line, for example, Karpas 422, WSU-DLCL2, Karpas 1106P, HT, SUDHL-10, OCI-LY19, SUDHL-4, or SUDHL-6 cell line.

In some embodiments, the number and type of cells can be monitored, for example, by measuring changes in morphology and cell surface markers using standard cell detection techniques such as flow cytometry, cell sorting, immunocytochemistry (e.g., staining with tissue specific or cell-marker specific antibodies) fluorescence activated cell sorting (FACS), magnetic activated cell sorting (MACS), by examination of the morphology of cells using light or confocal microscopy, and/or by measuring changes in gene expression using techniques well known in the art, such as PCR and gene expression profiling. These techniques can be used, too, to identify cells that are positive for one or more particular markers. Fluorescence activated cell sorting (FACS) is a well-known method for separating particles, including cells, based on the fluorescent properties of the particles (Kamarch, 1987, Methods Enzymol, 151:150-165). Laser excitation of fluorescent moieties in the individual particles results in a small electrical charge allowing electromagnetic separation of positive and negative particles from a mixture. In one embodiment, cell surface marker-specific antibodies or ligands are labeled with distinct fluorescent labels. Cells are processed through the cell sorter, allowing separation of cells based on their ability to bind to the antibodies used. FACS sorted particles may be directly deposited into individual wells of 96-well or 384-well plates to facilitate separation and cloning.

In certain embodiments, subsets of cells are used or detected in the methods provided herein. Methods to sort and isolate specific populations of cells are well-known in the art and can be based on cell size, morphology, or intracellular or extracellular markers. Such methods include, but are not limited to, flow cytometry, flow sorting, FACS, bead based separation such as magnetic cell sorting, size-based separation (e.g., a sieve, an array of obstacles, or a filter), sorting in a microfluidics device, antibody-based separation, sedimentation, affinity adsorption, affinity extraction, density gradient centrifugation, laser capture microdissection, etc.

In one embodiment, the RNA (e.g., mRNA) or protein is purified and the presence or absence of a biomarker is measured by gene or protein expression analysis. In certain embodiments, the presence or absence of a biomarker is measured by quantitative real-time PCR (QRT-PCR), microarray, flow cytometry or immunofluorescence. In other embodiments, the presence or absence of a biomarker is measured by enzyme-linked immunosorbent assay-based methodologies (ELISA) or other similar methods known in the art.

5.4.5. Methods of Detecting mRNA Levels in a Sample

Several methods of detecting or quantitating mRNA levels are known in the art. Exemplary methods include but are not limited to northern blots, ribonuclease protection assays, PCR-based methods, and the like. The mRNA sequence, e.g., the mRNA of CRBN or CRBN-associated proteins, or a fragment thereof, can be used to prepare a probe that is at least partially complementary. The probe can then be used to detect the mRNA sequence in a sample, using any suitable assay, such as PCR-based methods, Northern blotting, a dipstick assay, and the like.

In other embodiments, a nucleic acid assay for testing for immunomodulatory activity in a biological sample can be prepared. An assay typically contains a solid support and at least one nucleic acid contacting the support, where the nucleic acid corresponds to at least a portion of an mRNA that has altered expression during an immunomodulatory treatment in a patient, such as the mRNA of CRBN or CRBN-associated proteins. The assay can also have a means for detecting the altered expression of the mRNA in the sample.

The assay method can be varied depending on the type of mRNA information desired. Exemplary methods include but are not limited to Northern blots and PCR-based methods (e.g., qRT-PCR). Methods such as qRT-PCR can also accurately quantitate the amount of the mRNA in a sample.

Any suitable assay platform can be used to determine the presence of the mRNA in a sample. For example, an assay may be in the form of a dipstick, a membrane, a chip, a disk, a test strip, a filter, a microsphere, a slide, a multiwell plate, or an optical fiber. An assay system may have a solid support on which a nucleic acid corresponding to the mRNA is attached. The solid support may comprise, for example, a plastic, silicon, a metal, a resin, glass, a membrane, a particle, a precipitate, a gel, a polymer, a sheet, a sphere, a polysaccharide, a capillary, a film a plate, or a slide. The assay components can be prepared and packaged together as a kit for detecting an mRNA.

The nucleic acid can be labeled, if desired, to make a population of labeled mRNAs. In general, a sample can be labeled using methods that are well known in the art (e.g., using DNA ligase, terminal transferase, or by labeling the RNA backbone, etc.; see, e.g., Ausubel, et al., Short Protocols in Molecular Biology, 3rd ed., Wiley & Sons 1995 and Sambrook et al., Molecular Cloning: A Laboratory Manual, Third Edition, 2001 Cold Spring Harbor, N.Y.). In some embodiments, the sample is labeled with fluorescent label. Exemplary fluorescent dyes include but are not limited to xanthene dyes, fluorescein dyes, rhodamine dyes, fluorescein isothiocyanate (FITC), 6 carboxyfluorescein (FAM), 6 carboxy-2′,4′,7′,4,7-hexachlorofluorescein (HEX), 6 carboxy 4′, 5′ dichloro 2′, 7′ dimethoxyfluorescein (JOE or J), N,N,N′,N′ tetramethyl 6 carboxyrhodamine (TAMRA or T), 6 carboxy X rhodamine (ROX or R), 5 carboxyrhodamine 6G (R6G5 or G5), 6 carboxyrhodamine 6G (R6G6 or G6), and rhodamine 110; cyanine dyes, e.g. Cy3, Cy5 and Cy7 dyes; Alexa dyes, e.g. Alexa-fluor-555; coumarin, Diethylaminocoumarin, umbelliferone; benzimide dyes, e.g. Hoechst 33258; phenanthridine dyes, e.g. Texas Red; ethidium dyes; acridine dyes; carbazole dyes; phenoxazine dyes; porphyrin dyes; polymethine dyes, BODIPY dyes, quinoline dyes, Pyrene, Fluorescein Chlorotriazinyl, R110, Eosin, JOE, R6G, Tetramethylrhodamine, Lissamine, ROX, Napthofluorescein, and the like.

In some embodiments, the mRNA sequences comprise at least one mRNA selected from the group consisting of the mRNA of DDB1, PABPC1, HNRNPR, RPL19, SYNCRIP, H2AFX, HSPA8, ALDOA, HIST1H2AA, HSPA1A, XRCC6, RPL12, RPL18A, RPL4, HNRNPA2B1, HNRNPC, RPS2, SEC24C, RPL9, USP15, SEC24A, CTPS, ABCE1, EEF1A1, IPO5, CPSF6, KCNAB2, C7ORF42, SMC4, GNB3, H2AFZ, HIST1H1C, HIST1H1D, HIST1H1E, ACTB, CSNK2A1, CRBN, DDX21, DHX9, DNAJC1, G3BP1, HSPA1B, IGF2BP2, RPL10A, RPL13A, RPL14, RPL15, RPL21, RPL3, RPL30, RPL7, RPL7A, RPLP1, RPLP2, MYH10, ILF3, NCL, RPS13, RPS16, RPS19, RPS6, SND1, EIF2S2, HNRNPH2, UBB, EEF1G, TBL1XR1, NACA, EIF4A1, FASN, PPAT, G3BP2, TUBA1A, UBAP2L, MCM2, UAP1, TUBA1C, EIF2S1, EIF3J, PRKDC, MCM7, RPL11, TUBA1B, STAT3, PTRH2, PABPC4, PTPRC, MACF1, UBE2O, DUT, GNB2L1, NUP88, H2AFJ, SEC23B, PDXK, ACLY, ARID1A, GBE1, HSPA9, DDX17, FUBP1, FBXO21, EWSR1, IFI16, YWHAE, UBA52, COPSE, GNAS, UBE2Q1, FERMT3, NAP1L2, TPD52, VAPA, EEF1AL3, DDIT4, NEDD8, HIST1H1A, HIST1H1B, PCM1, IKZF1, IKZF3, IFITM3, or CSNK1A1, or a fragment thereof. In one embodiment, the mRNA is Ikaros mRNA. In another embodiment, the mRNA is Aiolos mRNA. In another embodiment, the mRNA is IFITM3 mRNA. In another embodiment, the mRNA is CSNK1A1 mRNA. The nucleic acids may be present in specific, addressable locations on a solid support; each corresponding to at least a portion of mRNA sequences that are differentially expressed upon treatment of an immunomodulatory compound in a cell or a patient.

A typical mRNA assay method can contain the steps of 1) obtaining surface-bound subject probes; 2) hybridization of a population of mRNAs to the surface-bound probes under conditions sufficient to provide for specific binding (3) post-hybridization washes to remove nucleic acids not bound in the hybridization; and (4) detection of the hybridized mRNAs. The reagents used in each of these steps and their conditions for use may vary depending on the particular application.

Hybridization can be carried out under suitable hybridization conditions, which may vary in stringency as desired. Typical conditions are sufficient to produce probe/target complexes on a solid surface between complementary binding members, i.e., between surface-bound subject probes and complementary mRNAs in a sample. In certain embodiments, stringent hybridization conditions may be employed.

Hybridization is typically performed under stringent hybridization conditions. Standard hybridization techniques (e.g. under conditions sufficient to provide for specific binding of target mRNAs in the sample to the probes) are described in Kallioniemi et al., Science 258:818-821 (1992) and WO 93/18186. Several guides to general techniques are available, e.g., Tijssen, Hybridization with Nucleic Acid Probes, Parts I and II (Elsevier, Amsterdam 1993). For descriptions of techniques suitable for in situ hybridizations, see Gall et al. Meth. Enzymol., 21:470-480 (1981); and Angerer et al. in Genetic Engineering: Principles and Methods (Setlow and Hollaender, Eds.) Vol 7, pgs 43-65 (Plenum Press, New York 1985). Selection of appropriate conditions, including temperature, salt concentration, polynucleotide concentration, hybridization time, stringency of washing conditions, and the like will depend on experimental design, including source of sample, identity of capture agents, degree of complementarity expected, etc., and may be determined as a matter of routine experimentation for those of ordinary skill in the art.

Those of ordinary skill will readily recognize that alternative but comparable hybridization and wash conditions can be utilized to provide conditions of similar stringency.

After the mRNA hybridization procedure, the surface bound polynucleotides are typically washed to remove unbound nucleic acids. Washing may be performed using any convenient washing protocol, where the washing conditions are typically stringent, as described above. The hybridization of the target mRNAs to the probes is then detected using standard techniques.

Other methods, such as PCR-based methods, can also be used to follow the expression of CRBN or CRB-associated proteins. Examples of PCR methods can be found in the literature. Examples of PCR assays can be found in U.S. Pat. No. 6,927,024, which is incorporated by reference herein in its entirety. Examples of RT-PCR methods can be found in U.S. Pat. No. 7,122,799, which is incorporated by reference herein in its entirety. A method of fluorescent in situ PCR is described in U.S. Pat. No. 7,186,507, which is incorporated by reference herein in its entirety.

In some embodiments, Real-Time Reverse Transcription-PCR (qRT-PCR) can be used for both the detection and quantification of RNA targets (Bustin, et al., 2005, Clin. Sci., 109:365-379). Quantitative results obtained by qRT-PCR are generally more informative than qualitative data. Thus, in some embodiments, qRT-PCR-based assays can be useful to measure mRNA levels during cell-based assays. The qRT-PCR method is also useful to monitor patient therapy. Examples of qRT-PCR-based methods can be found, for example, in U.S. Pat. No. 7,101,663, which is incorporated by reference herein in its entirety.

In contrast to regular reverse transcriptase-PCR and analysis by agarose gels, real-time PCR gives quantitative results. An additional advantage of real-time PCR is the relative ease and convenience of use. Instruments for real-time PCR, such as the Applied Biosystems 7500, are available commercially, as are the reagents, such as TaqMan Sequence Detection chemistry. For example, TaqMan® Gene Expression Assays can be used, following the manufacturer's instructions. These kits are pre-formulated gene expression assays for rapid, reliable detection and quantification of human, mouse and rat mRNA transcripts. An exemplary PCR program, for example, is 50° C. for 2 minutes, 95° C. for 10 minutes, 40 cycles of 95° C. for 15 seconds, then 60° C. for 1 minute.

To determine the cycle number at which the fluorescence signal associated with a particular amplicon accumulation crosses the threshold (referred to as the CT), the data can be analyzed, for example, using a 7500 Real-Time PCR System Sequence Detection software v1.3 using the comparative CT relative quantification calculation method. Using this method, the output is expressed as a fold-change of expression levels. In some embodiments, the threshold level can be selected to be automatically determined by the software. In some embodiments, the threshold level is set to be above the baseline but sufficiently low to be within the exponential growth region of an amplification curve.

5.4.6. Methods of Detecting Polypeptide or Protein Levels in a Sample

Several protein detection and quantitation methods can be used to measure the level of CRBN-associated proteins. Any suitable protein quantitation method can be used. In some embodiments, antibody-based methods are used. Exemplary methods that can be used include but are not limited to immunoblotting (western blot), enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, flow cytometry, cytometric bead array, mass spectroscopy, and the like. Several types of ELISA are commonly used, including direct ELISA, indirect ELISA, and sandwich ELISA. In one embodiment, the CRBN-associated protein is Ikaros. In another embodiment, the CRBN-associated protein is Aiolos. In another embodiment, the CRBN-associated protein is interferon or an interferon pathway protein. In another embodiment, the CRBN-associated protein is casein kinase 1, alpha 1.

5.5 Substrate CRBN-Modifying Agents as Bridge to Substrate

Also provided herein are methods of using CMA as a bridge or “molecular glue” between CRBN, or a CRBN complex thereof, and a substrate.

Small molecules, such as plant auxins have previously been shown to promote protein-protein interactions in ubiquitin ligases. See, e.g., Tan et al. (2007) “Mechanism of auxin perception by the TIR1 ubiquitin ligase” Nature 446:640-645. Auxins, such as indole-3-acetic acid (IAA), are plant hormones that control many aspects of plant growth. Recent genetic and molecular studies in Arabidopsis revealed a crucial intracellular auxin signaling pathway in which a ubiquitin-dependent proteolytic system has a key role in sensing and transducing the hormone signal to transcriptional programs. At the center of the signaling cascade is the ubiquitin-ligase complex, SCF^(TIR1), which promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1, the F-box protein subunit of SCF^(TIR1) functions as the true auxin receptor. It has been shown that auxin binds directly to SCF^(TIR1) and promotes the interaction between TIR1 and Aux/IAAs. Using crystallographic analysis, Tan et al. showed that TIR1 has a auxin and substrate binding pocket, analogous to a three-wall room with an open ceiling. The natural auxin, IAA, binds and is tethered to the bottom of the TIR1 pocket. IAA7 degron peptide is the natural substrate and docks to the auxin-bound TIR1, enclosing the three-walled TIR1 pocket. While auxin binding does not induce significant conformational changes of the TIR1 hormone receptor, auxin does serve to enhance the substrate-binding activity of TIR1 by filling a cavity between the two proteins and extending the protein interaction interface. Upon interacting with both TIR1 and the substrate polypeptide, auxin mediates the formation of a continuous hydrophobic core among the three proteins, and acts as a “molecular glue” rather than an alosteric switch.

Jasomonites are another family of plant hormones that regulate plan growth, development and response to stress. See, e.g., Shears et al. (2010) “Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor” Nature 468:400-407. COI1 shares high homology with TIR1 and is an F-box protein that functions as the substrate-recruiting module of the Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligase complex. The jasmonate zim domain (JAZ) family of transcriptional repressors are SCF^(COI1) substrate targets, which associate with COI1 in a hormone-dependent manner. Crystallographic studies reveals that the direct interaction of jasmonite hormones with both the COI1 and JAZ protein is another example of utilization of a “molecular glue” mechanism to enhance the substrate-binding activity of the receptor.

5.6 Substrate Recruitment by CRBN-Modifying Agents

In certain embodiments, provided herein are methods of recruiting a substrate for ubiquitination by a E3 ubiquitination ligase complex comprising CRBN. In some embodiments, the method comprises contacting a CRBN with a CMA, resulting in a three-dimensional change of the CRBN (e.g., in the CMA-binding pocket) as provided elsewhere herein. In some embodiments, the method results in a CRBN conformational change. In other embodiments, the method results in an alteration of the properties of a CRBN surface. In a specific embodiment, the CRBN conformational change or alteration results in recruitment and ubiquitination of the substrate. In certain embodiments, the substrate is not ubiquitinated by the E3 ubiquitination ligase complex in the absence of the CMA. In one embodiment, the compound induces a conformational change or alteration having atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7; or a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, the conformational change or alteration is as compared to that having atomic coordinates as set forth in any one of Tables 3, 4, 5, 6 or 7; or a three dimensional structure as set forth in any one of FIG. 12-18 or 20. In certain embodiments, an isoindolinone ring is exposed on the surface of a CRBN-CMA complex. In some embodiments, the isoindolinone ring of the CRBN-CMA complex forms part of a neomorphic interface in substrate recruitment. In certain embodiments, the unused hydrophobic and/or polar bonding potential of the CMA and adjacent protein surface alters substrate recruitment. In other embodiments, the unused hydrophobic and/or polar bonding potential of the CMA and adjacent protein surface enhances substrate recruitment.

In a one aspect, provided herein is a method of recruiting a substrate for ubiquitination by a E3 ubiquitination ligase complex comprising CRBN, said method comprising contacting said CRBN with a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), wherein said CRBN conformational change or alteration results in recruitment and ubiquitination of said substrate; and wherein said substrate is not ubiquitinated by said E3 ubiquitination ligase complex in the absence of said compound. In some embodiments, the conformational change or alteration is as compared to the CMA binding pocket when the CRBN is contacted with a reference compound. In some embodiments, a CRBN conformational change is induced. In other embodiments, an alteration of the properties of a CRBN surface are induced. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

In another aspect, provided herein is a method of identifying a substrate ubiquitinated by a E3 ubiquitination ligase complex comprising CRBN, said method comprising: (i) contacting said CRBN with a compound that induces a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or otherwise alters the properties of a CRBN surface (e.g., on an adjacent region of the protein), wherein said CRBN conformational change or alteration results in ubiquitination of said substrate, (ii) assaying for ubiquitination of one or more substrates, and (iii) identifying said one or more ubiquitinated substrates; wherein said substrate is not ubiquitinated by said E3 ubiquitination ligase complex in the absence of said compound. In some embodiments, the compound induces a CRBN conformational change or alteration. In other embodiments, the compound alters the properties of the CRBN surface. In certain embodiments, the properties of the CRBN surface are altered by the placement of compound appendages. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In some embodiments, the conformational change or alteration in said CMA binding pocket has an effect on W380, W386 and/or W400 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on E377 of CRBN. In other embodiments, the conformational change or alteration in said CMA binding pocket has an effect on V388 of CRBN. In certain embodiments, the conformational change or alteration in said CMA binding pocket has an effect on an adjacent region of the protein. Also provided is a substrate identified by this method. In some embodiments, the conformational change or alteration is as compared to the CMA binding pocket when the CRBN is contacted with a reference compound. In certain embodiments, the conformational change or alteration occurs in a CMA binding pocket of the CRBN. In an embodiment, the conformational change or alteration is assessed by x-ray crystallography. In another embodiment, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of conformational change (e.g., within the CMA-binding pocket of the CRBN) or alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein). In certain embodiments, the conformational change or alteration is assessed by a method comprising (a) (i) obtaining a first three-dimensional structure of CRBN and a reference compound; (b) (i) obtaining a second three-dimensional structure of CRBN and the test compound; and (c) comparing said first three-dimensional structure with said second three-dimensional structure; wherein a difference in the first and second three-dimensional structures is indicative of a compound that induces a CRBN conformational change or alteration. In some embodiments, the first and/or second three-dimensional structures include a CMA binding domain of the CRBN. In other embodiments, the three-dimensional structure is assessed using x-ray crystallography, NMR spectroscopy, dual polarization interferometry, vibrational spectroscopy, or cryo-elecron microscopy. In some embodiments, the CRBN is further bound to DDB1, Cul4, Roc1, or any combination thereof.

5.7 Changes in Substrate Distribution and Abundance

Also provided herein are methods of modulating the distribution pattern and/or abundance of a substrate in a cell. In some embodiments, the method comprises contacting a CRBN with a CMA, resulting in a CRBN conformational change (e.g., within the CMA-binding pocket of the CRBN) or other alteration of the properties of a CRBN surface (e.g., on an adjacent region of the protein), as provided elsewhere herein. In some embodiments, the CRBN has a conformational change. In other embodiments, the CRBN has an alteration of the properties of the CRBN surface. In a specific embodiment, the CRBN conformational change or alteration results in a modulation of the distribution pattern of a substrate in a cell. In other embodiments, the CRBN conformational change or alteration results in a modulation of the abundance of a substrate in a cell. In some embodiments, the modulation is an increase. In other embodiments, the modulation is a decrease. In certain embodiments, the substrate is a CRBN-associated protein.

5.8 Degron in Substrate and Methods for Identifying Substrates Based on Degron Information

As shown in the Examples, certain region (amino acid sequence or degron) of the substrate protein is important for its binding to CRBN and for its functionality, and such degron may be shared by various CRBN substrates and compound targets. Thus, in another aspect, provided herein are a degron in the CAP, and methods for searching new substrates of CRBN and/or targets of the treatment compound based on the degron information.

In some embodiments, provided herein is a degron in a CAP, wherein the degron is a structural degron. In some embodiments, the structural degron comprises an a-turn.

In certain embodiments, the degron comprises 4 amino acid residues, with positions designated as i, i+1, i+2, and i+3, respectively. In other embodiments, the degron further comprises an amino acid residue at position i−1.

In some embodiments, the amino acid residues at position i, i+1, or i+2 form hydrogen bonds with amino acid residues on CRBN. In one embodiment, the amino acid residue at position i form hydrogen bonds with amino acid residues on CRBN. In another embodiment, the amino acid residue at position i+1 form hydrogen bonds with amino acid residues on CRBN. In yet another embodiment, the amino acid residue at position i+2 form hydrogen bonds with amino acid residues on CRBN. In still another embodiment, the amino acid residues at positions i and i+1 form hydrogen bonds with amino acid residues on CRBN. In one embodiment, the amino acid residues at positions i and i+2 form hydrogen bonds with amino acid residues on CRBN. In another embodiment, the amino acid residues at positions i+1 and i+2 form hydrogen bonds with amino acid residues on CRBN. In yet another embodiment, the amino acid residues at position i, i+1, and i+2 form hydrogen bonds with amino acid residues on CRBN.

In certain embodiments, the amino acid residue at position i+3 is Glycine (G).

In some embodiments, the degron is stabilized by internal hydrogen bonds from an ASX motif and a ST motif.

In certain embodiments, the degron comprises an ASX motif that starts with Aspartic Acid (D). In other embodiments, the degron comprises an ASX motif that starts with Asparagine (N).

In some embodiments, the degron comprises a ST motif that starts with Serine (S). In other embodiments, the degron comprises a ST motif that starts with Threonine (T).

In certain embodiments, the degron comprises an amino acid sequence of [D/N]XX[S/T]G (SEQ ID NO:11), wherein X can be any amino acid residue. In one embodiment, the degron comprises an amino acid sequence of DXXSG (SEQ ID NO:12). In another embodiment, the degron comprises an amino acid sequence of NXXSG (SEQ ID NO:13). In yet another embodiment, the degron comprises an amino acid sequence of DXXTG (SEQ ID NO:14). In still another embodiment, the degron comprises an amino acid sequence of NXXTG (SEQ ID NO:15).

In some embodiments, the degron comprises an amino acid sequence of CXXCG (SEQ ID NO:16), wherein X can be any amino acid residue. In certain embodiments, the degron comprises an amino acid sequence of NXXNG (SEQ ID NO:17), wherein X can be any amino acid residue.

In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 300-450 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 350-430 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 351-422 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 351-357 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 377-400 of CRBN. In some embodiments, the CRBN is the isoform 1 of CRBN. In other embodiments, the CRBN is the isoform 2 of the CRBN. In some embodiments, the CRBN is the human CRBN.

In some embodiments, one or more amino acids of the degron form interactions with one or more amino acids selected from a group consisting of the amino acid residues 150, 352, 353, 355, 357, 377, 380, 386, 388, 397, and 400 of isoform 1 of human CRBN. In some embodiments, the interaction is a hydrogen bond. In other embodiments, the interaction is a Van der Waals interaction.

In some embodiments, the CAP is a substrate of CRBN. In one embodiment, the substrate of CRBN is GSPT1. In another embodiment, the substrate of CRBN is IKZF1. In yet another embodiment, the substrate of CRBN is CK1a.

In another aspect, provided herein is a method of identifying a CAP, comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay; and (c) identifying the protein as a CAP if the protein specifically binds to CRBN in the CRBN-binding assay.

In yet another aspect, provided herein is a method of identifying a CAP, comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay; and (c) identifying the protein as a CAP if the protein level decreases in the CRBN-mediated degradation assay.

In yet another aspect, provided herein is a method of identifying a target of a compound comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein specifically binds to CRBN in the CRBN-binding assay.

In yet another aspect, provided herein is a method of identifying a target of a compound comprising: (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein level decreases in the CRBN-mediated degradation assay.

In yet another aspect, provided herein is a method of identifying a CAP or a target of a compound comprising: searching for a protein that has a region of structural similarity to a degron region provided herein.

In some embodiments, provided herein is a method of identifying a CAP, comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay; and (c) identifying the protein as a CAP if the protein specifically binds to CRBN in the CRBN-binding assay ubiquitination assay. In some embodiments, the method comprises testing the protein in a CRBN-binding assay. In other embodiments, the method comprises testing the protein in an ubiquitination assay.

In other embodiments, provided herein is a method of identifying a CAP, comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment; and (c) identifying the protein as a CAP if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment. In some embodiments, the method comprises testing the protein in a CRBN-mediated degradation assay. In some embodiments, the method comprises testing the protein in an ubiquitination assay. In other embodiments, the method comprises testing the protein in a proteomics experiment.

In yet other embodiments, provided herein is a method of identifying a target of a compound comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-binding assay or ubiquitination assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein specifically binds to CRBN in the CRBN-binding assay or ubiquitination assay. In some embodiments, the method comprises testing the protein in a CRBN-binding assay. In other embodiments, the method comprises testing the protein in an ubiquitination assay.

In yet other embodiments, provided herein is a method of identifying a target of a compound comprising: (a) searching for a protein comprising a region having a similar structure of a degron in a known CAP; (b) testing the protein in a CRBN-mediated degradation assay, ubiquitination assay, or proteomics experiment in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein level decreases in the CRBN-mediated degradation assay, ubiquitination assay or proteomics experiment. In some embodiments, the method comprises testing the protein in a CRBN-mediated degradation assay in the presence of the compound. In some embodiments, the method comprises testing the protein in an ubiquitination assay in the presence of the compound. In other embodiments, the method comprises testing the protein in a proteomics experiment in the presence of the compound.

In some embodiments of the various methods provided herein, the method comprises computationally searching for a protein based on the structural similarity to a degron provided herein. In one embodiment, the method provided herein comprises searching for a degron or a similar structure on the surface of proteins of known structure. In another embodiment, the method provided herein comprises searching for a similar structural feature to the known degron on the surface of proteins of known structure. In yet another embodiment, the method provided herein comprises searching for a glycine on the surface of proteins of known structure.

In yet another aspect, provided herein is a method of identifying a CAP or a target of a compound comprising: searching for a protein able to bind to a surface of CRBN adjacent to the site of ligand binding via features other than the known degron, e.g., by performing docking studies.

In some embodiments of the various methods provided herein, the method further comprises searching for proteins homologous to the proteins with the degron structure or predicted to have ability to bind CRBN.

In certain embodiments of the various methods provided herein, the CAP is a substrate of CRBN.

In some embodiments of the various methods provided herein, the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11). In other embodiments, the amino acid sequence of the degron is CXXCG (SEQ ID NO:16). In yet other embodiments, the amino acid sequence of the degron is NXXNG (SEQ ID NO:17).

In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 300-450 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 350-430 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 351-422 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 351-357 of CRBN. In some embodiments, one or more amino acids of the degron form hydrogen bonds with one or more amino acids within amino acid residues 377-400 of CRBN. In some embodiments, the CRBN is the isoform 1 of CRBN. In other embodiments, the CRBN is the isoform 2 of the CRBN. In some embodiments, the CRBN is the human CRBN.

In some embodiments, one or more amino acids of the degron form interactions with one or more amino acids selected from a group consisting of the amino acid residues 150, 352, 353, 355, 357, 377, 380, 386, 388, 397, and 400 of isoform 1 of human CRBN. In some embodiments, the interaction is a hydrogen bond. In other embodiments, the interaction is a Van der Waals interaction.

In some embodiments of the various methods provided herein, the compound is a CMA. In other embodiments of the various methods provided herein, the compound is an immunomodulatory compound. In still other embodiments of the various methods provided herein, the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E. In one embodiment, the compound is thalidomide. In another embodiment, the compound is lenalidomide. In yet another embodiment, the compound is pomalidomide. In still another embodiment, the compound is Compound A. In one embodiment, the compound is Compound B. In another embodiment, the compound is Compound C. In yet another embodiment, the compound is Compound D. In still another embodiment, the compound is Compound E.

5.9 Compounds

Compounds for the methods provided herein include, but are not limited to, the immunomodulatory compounds, a group of compounds that can be useful to treat several types of human diseases, including certain cancers.

As used herein and unless otherwise indicated, the term “immunomodulatory compound” or “immunomodulatory agent” can encompass certain small organic molecules that inhibit LPS induced monocyte TNF-α, IL-1ß, IL-12, IL-6, MIP-1α, MCP-1, GM-CSF, G-CSF, and COX-2 production. Without being limited by a particular theory, one of the biological effects exerted by the immunomodulatory compounds disclosed herein is the reduction of myeloid cell TNF-α production. Immunomodulatory compounds disclosed herein may enhance the degradation of TNF-α mRNA. Further, without being limited by theory, immunomodulatory compounds disclosed herein may also be potent co-stimulators of T cells and increase cell proliferation dramatically in a dose dependent manner. Immunomodulatory compounds disclosed herein may also have a greater co-stimulatory effect on the CD8+ T cell subset than on the CD4+ T cell subset. In addition, the compounds may have anti-inflammatory properties against myeloid cell responses, yet efficiently co-stimulate T cells to produce greater amounts of IL-2, IFN-γ, and to enhance T cell proliferation and CD8+ T cell cytotoxic activity. Further, without being limited by a particular theory, immunomodulatory compounds disclosed herein may be capable of acting both indirectly through cytokine activation and directly on Natural Killer (“NK”) cells and Natural Killer T (“NKT”) cells, and increase the NK cells' ability to produce beneficial cytokines such as, but not limited to, IFN-γ, and to enhance NK and NKT cell cytotoxic activity.

Exemplary immunomodulatory compounds provided herein include but are not limited to thalidomide, lenalidomide, pomalidomide, Compound A, Compound B, Compound C, Compound D, and Compound E.

In a specific embodiment, the compound is thalidomide.

In another specific embodiment, the compound is lenalidomide.

In yet another specific embodiment, the compound is pomalidomide.

In yet another specific embodiment, the compound is 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (“Compound A”), which has the following structure:

or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Compound A can be prepared as described in U.S. Pat. No. 7,635,700, the disclosure of which is incorporated herein by reference in its entirety. The compound can be also synthesized according to other methods apparent to those of skill in the art based upon the teaching herein. In certain embodiments, Compound A is in a crystalline form described in U.S. Provisional Pat. App. No. 61/451,806, filed Mar. 11, 2011, which is incorporated herein by reference in its entirety. In some embodiments, the hydrochloride salt of Compound A is used in the methods provided herein. Methods of treating, preventing and/or managing cancers and other diseases using Compound A are described in U.S. Provisional at. App. No. 61/451,995, filed Mar. 11, 2011, which is incorporated herein by reference in its entirety.

In yet another specific embodiment, the compound is 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (“Compound B”), which has the following structure:

or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Compound B and methods of preparing the same are described in U.S. Pat. No. 8,518,972, which is incorporated herein by reference in its entirety.

In yet another specific embodiment, the compound is 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea (“Compound C”), which has the following structure:

or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. An exemplary method for preparing Compound C is illustrated in Section 6.6 below.

In yet another specific embodiment, the compound is 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide (“Compound D”), which has the following structure:

or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

In yet another specific embodiment, the compound is 2-(4-fluorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide (“Compound E”), which has the following structure:

or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopologue, prodrug, hydrate, co-crystal, clathrate, or a polymorph thereof.

Compounds D and E and methods of preparing the same are described in U.S. Pat. No. 9,499,514, which is incorporated herein by reference in its entirety.

Various immunomodulatory compounds disclosed herein contain one or more chiral centers, and can exist as racemic mixtures of enantiomers or mixtures of diastereomers. Thus, also provided herein is the use of stereomerically pure forms of such compounds, as well as the use of mixtures of those forms. For example, mixtures comprising equal or unequal amounts of the enantiomers of a particular immunomodulatory compounds may be used. These isomers may be asymmetrically synthesized or resolved using standard techniques such as chiral columns or chiral resolving agents. See, e.g., Jacques, J., et al., Enantiomers, Racemates and Resolutions (Wiley-Interscience, New York, 1981); Wilen, S. H., et al., Tetrahedron 33:2725 (1977); Eliel, E. L., Stereochemistry of Carbon Compounds (McGraw-Hill, N Y, 1962); and Wilen, S. H., Tables of Resolving Agents and Optical Resolutions p. 268 (E. L. Eliel, Ed., Univ. of Notre Dame Press, Notre Dame, Ind., 1972).

All of the compounds described can either be commercially purchased or prepared according to the methods described in the patents or patent publications disclosed herein. Further, optically pure compounds can be asymmetrically synthesized or resolved using known resolving agents or chiral columns as well as other standard synthetic organic chemistry techniques.

In certain embodiments of the various compositions and methods provided herein, a CMA is an immunomodulatory compound provided herein. In other embodiments, a CMA is not an immunomodulatory compound provided herein.

It should be noted that if there is a discrepancy between a depicted structure and a name given that structure, the depicted structure is to be accorded more weight. In addition, if the stereochemistry of a structure or a portion of a structure is not indicated with, for example, bold or dashed lines, the structure or portion of the structure is to be interpreted as encompassing all stereoisomers of it.

5.10 Treatment for Patients with a CRBN-Mediated Disease

Also provided herein is a method of treating and preventing a CRBN-mediated disease, which comprises administering to a patient a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In certain embodiments, the CRBN-mediated disease or disorder is a cancer. In certain embodiments provided herein is a compound provided herein for use in a method of treating and preventing a CRBN-mediated disease, the method comprises administering to a patient the compound, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

In another embodiment, provided herein is method of managing a CRBN-mediated disease, which comprises administering to a patient a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In certain embodiments, the CRBN-mediated disease or disorder is a cancer. In certain embodiments provided herein is a compound provided herein for use in a method of managing a CRBN-mediated disease, the method comprises administering to a patient the compound, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Provided herein are methods of treating or managing lymphoma, particularly non-Hodgkin's lymphoma. In some embodiments, provided herein are methods for the treatment or management of non-Hodgkin's lymphoma (NHL), including but not limited to, diffuse large B-cell lymphoma (DLBCL), using prognostic factors. In certain embodiments provided herein is a compound provided herein for use in a method of treating or managing lymphoma, particularly non-Hodgkin's lymphoma.

Also provided herein are methods of treating patients who have been previously treated for a CRBN-mediated disease or disorder (e.g., a cancer) but are non-responsive to standard therapies, as well as those who have not previously been treated. Also provided herein are methods of treating patients regardless of patient's age, although some diseases or disorders are more common in certain age groups. Also provided herein are methods of treating patients who have undergone surgery in an attempt to treat the disease or condition at issue, as well as those who have not. In some embodiments provided herein a compounds provided herein for use in methods of treating patients as mentioned above.

Because patients with cancer have heterogeneous clinical manifestations and varying clinical outcomes, the treatment given to a patient may vary, depending on his/her prognosis. The skilled clinician will be able to readily determine without undue experimentation specific secondary agents, types of surgery, and types of non-drug based standard therapy that can be effectively used to treat an individual patient with cancer.

As used herein, the term “cancer” includes, but is not limited to, solid tumors and blood born tumors. The term “cancer” refers to disease of skin tissues, organs, blood, and vessels, including, but not limited to, cancers of the bladder, bone, blood, brain, breast, cervix, chest, colon, endrometrium, esophagus, eye, head, kidney, liver, lymph nodes, lung, mouth, neck, ovaries, pancreas, prostate, rectum, stomach, testis, throat, and uterus. Specific cancers include, but are not limited to, advanced malignancy, amyloidosis, neuroblastoma, meningioma, hemangiopericytoma, multiple brain metastase, glioblastoma multiforms, glioblastoma, brain stem glioma, poor prognosis malignant brain tumor, malignant glioma, recurrent malignant glioma, anaplastic astrocytoma, anaplastic oligodendroglioma, neuroendocrine tumor, rectal adenocarcinoma, Dukes C & D colorectal cancer, unresectable colorectal carcinoma, metastatic hepatocellular carcinoma, Kaposi's sarcoma, karotype acute myeloblastic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma, cutaneous T-Cell lymphoma, cutaneous B-Cell lymphoma, diffuse large B-Cell lymphoma, low grade follicular lymphoma, malignant melanoma, malignant mesothelioma, malignant pleural effusion mesothelioma syndrome, peritoneal carcinoma, papillary serous carcinoma, gynecologic sarcoma, soft tissue sarcoma, scleroderma, cutaneous vasculitis, Langerhans cell histiocytosis, leiomyosarcoma, fibrodysplasia ossificans progressive, hormone refractory prostate cancer, resected high-risk soft tissue sarcoma, unrescectable hepatocellular carcinoma, Waldenstrom's macroglobulinemia, smoldering myeloma, indolent myeloma, fallopian tube cancer, androgen independent prostate cancer, androgen dependent stage IV non-metastatic prostate cancer, hormone-insensitive prostate cancer, chemotherapy-insensitive prostate cancer, papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, and leiomyoma

In certain embodiments, the cancer is a blood borne tumor. In certain embodiments, the blood borne tumor is metastatic. In certain embodiments, the blood borne tumor is drug resistant. In certain embodiments, the cancer is myeloma or lymphoma.

In certain embodiments, the cancer is a solid tumor. In certain embodiments, the solid tumor is metastatic. In certain embodiments, the solid tumor is drug-resistant. In certain embodiments, the solid tumor is hepatocellular carcinoma, prostate cancer, ovarian cancer, or glioblastoma.

In one embodiment, provided herein are methods of preventing relapsed/refractory multiple myeloma in patients with impaired renal function or a symptom thereof, comprising administering an effective amount of a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, tautomer or racemic mixtures thereof to a patient at risk of having relapsed/refractory multiple myeloma with impaired renal function. In one embodiment provided herein are compounds provided herein for use in the above-mentioned methods.

In certain embodiments, provided herein are methods for treating, preventing, and/or managing relapsed/refractory multiple myeloma in patients with impaired renal function. In certain embodiments provided herein are compounds provided herein for use in methods for treating, preventing, and/or managing relapsed/refractory multiple myeloma in patients with impaired renal function.

In certain embodiments, a therapeutically or prophylactically effective amount of the compound is from about 0.005 to about 1,000 mg per day, from about 0.01 to about 500 mg per day, from about 0.01 to about 250 mg per day, from about 0.01 to about 100 mg per day, from about 0.1 to about 100 mg per day, from about 0.5 to about 100 mg per day, from about 1 to about 100 mg per day, from about 0.01 to about 50 mg per day, from about 0.1 to about 50 mg per day, from about 0.5 to about 50 mg per day, from about 1 to about 50 mg per day, from about 0.02 to about 25 mg per day, or from about 0.05 to about 10 mg per day.

In certain embodiment, a therapeutically or prophylactically effective amount is from about 0.005 to about 1,000 mg per day, from about 0.01 to about 500 mg per day, from about 0.01 to about 250 mg per day, from about 0.01 to about 100 mg per day, from about 0.1 to about 100 mg per day, from about 0.5 to about 100 mg per day, from about 1 to about 100 mg per day, from about 0.01 to about 50 mg per day, from about 0.1 to about 50 mg per day, from about 0.5 to about 50 mg per day, from about 1 to about 50 mg per day, from about 0.02 to about 25 mg per day, or from about 0.05 to about 10 mg every other day.

In certain embodiments, the therapeutically or prophylactically effective amount is about 0.1, about 0.2, about 0.3, about 0.5, about 1, about 2, about 5, about 10, about 15, about 20, about 25, about 30, about 40, about 45, about 50, about 60, about 70, about 80, about 90, about 100, or about 150 mg per day.

In one embodiment, the recommended daily dose range of a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, for the conditions described herein lie within the range of from about 0.5 mg to about 50 mg per day, preferably given as a single once-a-day dose, or in divided doses throughout a day. In some embodiments, the dosage ranges from about 1 mg to about 50 mg per day. In other embodiments, the dosage ranges from about 0.5 to about 5 mg per day. Specific doses per day include 0.01, 0.05, 0.1, 0.2, 0.3, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 mg per day.

In a specific embodiment, the recommended starting dosage may be 0.01, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 1, 2, 3, 4, 5, 10, 15, 20, 25 or 50 mg per day. In another embodiment, the recommended starting dosage may be 0.5, 1, 2, 3, 4, or 5 mg per day. The dose may be escalated to 15, 20, 25, 30, 35, 40, 45 and 50 mg/day. In a specific embodiment, the compound can be administered in an amount of about 25 mg/day to patients with NHL (e.g., DLBCL). In a particular embodiment, the compound can be administered in an amount of about 10 mg/day to patients with NHL (e.g., DLBCL).

In certain embodiments, the therapeutically or prophylactically effective amount is from about 0.001 to about 100 mg/kg/day, from about 0.01 to about 50 mg/kg/day, from about 0.01 to about 25 mg/kg/day, from about 0.01 to about 10 mg/kg/day, from about 0.01 to about 9 mg/kg/day, 0.01 to about 8 mg/kg/day, from about 0.01 to about 7 mg/kg/day, from about 0.01 to about 6 mg/kg/day, from about 0.01 to about 5 mg/kg/day, from about 0.01 to about 4 mg/kg/day, from about 0.01 to about 3 mg/kg/day, from about 0.01 to about 2 mg/kg/day, or from about 0.01 to about 1 mg/kg/day.

The administered dose can also be expressed in units other than mg/kg/day. For example, doses for parenteral administration can be expressed as mg/m²/day. One of ordinary skill in the art would readily know how to convert doses from mg/kg/day to mg/m²/day to given either the height or weight of a subject or both (see, www.fda.gov/cder/cancer/animalframe.htm). For example, a dose of 1 mg/kg/day for a 65 kg human is approximately equal to 38 mg/m²/day.

In certain embodiments, the amount of the compound administered is sufficient to provide a plasma concentration of the compound at steady state, ranging from about 0.001 to about 500 μM, about 0.002 to about 200 μM, about 0.005 to about 100 μM, about 0.01 to about 50 μM, from about 1 to about 50 μM, about 0.02 to about 25 μM, from about 0.05 to about 20 μM, from about 0.1 to about 20 μM, from about 0.5 to about 20 μM, or from about 1 to about 20 μM.

In other embodiments, the amount of the compound administered is sufficient to provide a plasma concentration of the compound at steady state, ranging from about 5 to about 100 nM, about 5 to about 50 nM, about 10 to about 100 nM, about 10 to about 50 nM or from about 50 to about 100 nM.

As used herein, the term “plasma concentration at steady state” is the concentration reached after a period of administration of a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Once steady state is reached, there are minor peaks and troughs on the time dependent curve of the plasma concentration of the compound.

In certain embodiments, the amount of the compound administered is sufficient to provide a maximum plasma concentration (peak concentration) of the compound, ranging from about 0.001 to about 500 μM, about 0.002 to about 200 μM, about 0.005 to about 100 μM, about 0.01 to about 50 μM, from about 1 to about 50 μM, about 0.02 to about 25 μM, from about 0.05 to about 20 μM, from about 0.1 to about 20 μM, from about 0.5 to about 20 μM, or from about 1 to about 20 μM.

In certain embodiments, the amount of the compound administered is sufficient to provide a minimum plasma concentration (trough concentration) of the compound, ranging from about 0.001 to about 500 μM, about 0.002 to about 200 μM, about 0.005 to about 100 μM, about 0.01 to about 50 μM, from about 1 to about 50 μM, about 0.01 to about 25 μM, from about 0.01 to about 20 μM, from about 0.02 to about 20 μM, from about 0.02 to about 20 μM, or from about 0.01 to about 20 μM.

In certain embodiments, the amount of the compound administered is sufficient to provide an area under the curve (AUC) of the compound, ranging from about 100 to about 100,000 ng*hr/mL, from about 1,000 to about 50,000 ng*hr/mL, from about 5,000 to about 25,000 ng*hr/mL, or from about 5,000 to about 10,000 ng*hr/mL.

In certain embodiments, the patient to be treated with one of the methods provided herein has not been treated with anticancer therapy prior to the administration of a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In certain embodiments, the patient to be treated with one of the methods provided herein has been treated with anticancer therapy prior to the administration of a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. In certain embodiments, the patient to be treated with one of the methods provided herein has developed drug resistance to the anticancer therapy.

The methods provided herein encompass treating a patient regardless of patient's age, although some diseases or disorders are more common in certain age groups. Further provided herein is a method for treating a patient who has undergone surgery in an attempt to treat the disease or condition at issue, as well in one who has not. Because the subjects with cancer have heterogeneous clinical manifestations and varying clinical outcomes, the treatment given to a particular subject may vary, depending on his/her prognosis. The skilled clinician will be able to readily determine without undue experimentation, specific secondary agents, types of surgery, and types of non-drug based standard therapy that can be effectively used to treat an individual subject with cancer.

Depending on the disease to be treated and the subject's condition, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, may be administered by oral, parenteral (e.g., intramuscular, intraperitoneal, intravenous, CIV, intracistemal injection or infusion, subcutaneous injection, or implant), inhalation, nasal, vaginal, rectal, sublingual, or topical (e.g., transdermal or local) routes of administration. A compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, may be formulated, alone or together, in suitable dosage unit with pharmaceutically acceptable excipients, carriers, adjuvants and vehicles, appropriate for each route of administration.

In one embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered orally. In another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered parenterally. In yet another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered intravenously.

A compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, can be delivered as a single dose such as, e.g., a single bolus injection, or oral tablets or pills; or over time, such as, e.g., continuous infusion over time or divided bolus doses over time. The compound can be administered repeatedly if necessary, for example, until the patient experiences stable disease or regression, or until the patient experiences disease progression or unacceptable toxicity. For example, stable disease for solid tumors generally means that the perpendicular diameter of measurable lesions has not increased by 25% or more from the last measurement. Response Evaluation Criteria in Solid Tumors (RECIST) Guidelines, Journal of the National Cancer Institute 92(3): 205-216 (2000). Stable disease or lack thereof is determined by methods known in the art such as evaluation of patient symptoms, physical examination, visualization of the tumor that has been imaged using X-ray, CAT, PET, or MM scan and other commonly accepted evaluation modalities.

A compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, can be administered once daily (QD), or divided into multiple daily doses such as twice daily (BID), three times daily (TID), and four times daily (QID). In addition, the administration can be continuous (i.e., daily for consecutive days or every day), intermittent, e.g., in cycles (i.e., including days, weeks, or months of rest without drug). As used herein, the term “daily” is intended to mean that a therapeutic compound is administered once or more than once each day, for example, for a period of time. The term “continuous” is intended to mean that a therapeutic compound is administered daily for an uninterrupted period of at least 10 days to 52 weeks. The term “intermittent” or “intermittently” as used herein is intended to mean stopping and starting at either regular or irregular intervals. For example, intermittent administration of a compound provided herein is administration for one to six days per week, administration in cycles (e.g., daily administration for two to eight consecutive weeks, then a rest period with no administration for up to one week), or administration on alternate days. The term “cycling” as used herein is intended to mean that a therapeutic compound is administered daily or continuously but with a rest period.

In some embodiments, the frequency of administration is in the range of about a daily dose to about a monthly dose. In certain embodiments, administration is once a day, twice a day, three times a day, four times a day, once every other day, twice a week, once every week, once every two weeks, once every three weeks, or once every four weeks. In one embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once a day. In another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered twice a day. In yet another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered three times a day. In still another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered four times a day.

In certain embodiments, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once per day from one day to six months, from one week to three months, from one week to four weeks, from one week to three weeks, or from one week to two weeks. In certain embodiments, a compound provided herein, or a pharmaceutically acceptable salt or solvate thereof, is administered once per day for one week, two weeks, three weeks, or four weeks. In one embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once per day for one week. In another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once per day for two weeks. In yet another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once per day for three weeks. In still another embodiment, a compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered once per day for four weeks.

Further provided herein are methods for achieving one or more clinical endpoints associated with various hematological cancers such as AML and/or MDS comprising administering a therapeutically effective amount of the compound provided herein to a patient in need thereof.

Further provided herein are methods for increasing the overall survival (OS), complete remission rate (CRR), objective response rate (ORR), time to progression, relapse free survival (RFS), progression-free survival (PFS) event-free survival, duration of remission, duration of response, and/or time to remission/response of a patient having a hematological cancer comprising administering an effective amount of the compound provided herein. In certain embodiment, the ORR includes all responses of complete remission (CR) (i.e., morphologic leukemia-free state, morphologic CR, cytogenetic CR, molecular CR, and morphologic CR with incomplete blood recovery), and partial remission.

As used herein, Overall survival (OS) means the time from randomization in a clinical trial until death from any cause. Progression-free survival (PFS) means the time from randomization in a clinical trial until progression or death. Event-free survival (EFS) means the time from study entry until any treatment failure, including disease progression, treatment discontinuation for any reason, or death. Overall response rate (ORR) means the sum of the percentage of patients who achieve complete and partial responses. Duration of response (DoR) is the time from achieving a response until relapse or disease progression.

As used herein, “hematological cancer” includes myeloma, lymphoma and leukemia. In one embodiment, the myeloma is multiple myeloma. In some embodiments, the leukemia is, for example, acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukemia, chronic lymphocytic leukemia (CLL), hairy cell leukemia, myelodysplasia, myeloproliferative disorders, chronic myelogenous leukemia (CML), myelodysplastic syndrome (MDS), human lymphotropic virus-type 1 (HTLV-1) leukemia, mastocytosis, or B-cell acute lymphoblastic leukemia. In some embodiments, the lymphoma is, for example, diffuse large B-cell lymphoma (DLBCL), B-cell immunoblastic lymphoma, small non-cleaved cell lymphoma, human lymphotropic virus-type 1 (HTLV-1) leukemia/lymphoma, adult T-cell lymphoma, peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), mantle cell lymphoma (MCL), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), AIDS-related lymphoma, follicular lymphoma, small lymphocytic lymphoma, T-cell/histiocyte rich large B-cell lymphoma, transformed lymphoma, primary mediastinal (thymic) large B-cell lymphoma, splenic marginal zone lymphoma, Richter's transformation, nodal marginal zone lymphoma, or ALK-positive large B-cell lymphoma. In one embodiment, the hematological cancer is indolent lymphoma including, for example, DLBCL, follicular lymphoma, or marginal zone lymphoma.

5.11 Combination Therapy with a Second Active Agent

A compound provided herein, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, can also be combined or used in combination with other therapeutic agents useful in the treatment and/or prevention of cancer described herein.

As used herein, the term “in combination” includes the use of more than one therapy (e.g., one or more prophylactic and/or therapeutic agents). However, the use of the term “in combination” does not restrict the order in which therapies (e.g., prophylactic and/or therapeutic agents) are administered to a patient with a disease or disorder. A first therapy (e.g., a prophylactic or therapeutic agent such as a compound provided herein, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof) can be administered prior to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks before), concomitantly with, or subsequent to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks after) the administration of a second therapy (e.g., a prophylactic or therapeutic agent) to the subject. Triple therapy is also contemplated herein.

Administration of a compound provided herein and one or more second active agents to a patient can occur simultaneously or sequentially by the same or different routes of administration. The suitability of a particular route of administration employed for a particular active agent will depend on the active agent itself (e.g., whether it can be administered orally without decomposing prior to entering the blood stream) and the cancer being treated.

The route of administration of a compound provided herein is independent of the route of administration of a second therapy. In one embodiment, a compound provided herein is administered orally. In another embodiment, a compound provided herein is administered intravenously. Thus, in accordance with these embodiments, a compound provided herein is administered orally or intravenously, and the second therapy can be administered orally, parenterally, intraperitoneally, intravenously, intraarterially, transdermally, sublingually, intramuscularly, rectally, transbuccally, intranasally, liposomally, via inhalation, vaginally, intraoccularly, via local delivery by catheter or stent, subcutaneously, intraadiposally, intraarticularly, intrathecally, or in a slow release dosage form. In one embodiment, a compound provided herein and a second therapy are administered by the same mode of administration, orally or by IV. In another embodiment, a compound provided herein is administered by one mode of administration, e.g., by IV, whereas the second agent (an anticancer agent) is administered by another mode of administration, e.g., orally.

In one embodiment, the second active agent is administered intravenously or subcutaneously and once or twice daily in an amount of from about 1 to about 1000 mg, from about 5 to about 500 mg, from about 10 to about 350 mg, or from about 50 to about 200 mg. The specific amount of the second active agent will depend on the specific agent used, the type of disease being treated or managed, the severity and stage of disease, and the amount of a compound provided herein provided herein and any optional additional active agents concurrently administered to the patient. In certain embodiments, the second active agent is oblimersen (GENASENSE®), GM-CSF, G-CSF, SCF, EPO, taxotere, irinotecan, dacarbazine, transretinoic acid, topotecan, pentoxifylline, ciprofloxacin, dexamethasone, vincristine, doxorubicin, COX-2 inhibitor, IL2, IL8, IL18, IFN, Ara-C, vinorelbine, or a combination thereof.

In certain embodiments, GM-CSF, G-CSF, SCF or EPO is administered subcutaneously during about five days in a four or six week cycle in an amount ranging from about 1 to about 750 mg/m²/day, from about 25 to about 500 mg/m²/day, from about 50 to about 250 mg/m²/day, or from about 50 to about 200 mg/m²/day. In certain embodiments, GM-CSF may be administered in an amount of from about 60 to about 500 mcg/m² intravenously over 2 hours or from about 5 to about 12 mcg/m²/day subcutaneously. In certain embodiments, G-CSF may be administered subcutaneously in an amount of about 1 mcg/kg/day initially and can be adjusted depending on rise of total granulocyte counts. The maintenance dose of G-CSF may be administered in an amount of about 300 (in smaller patients) or 480 mcg subcutaneously. In certain embodiments, EPO may be administered subcutaneously in an amount of 10,000 Unit 3 times per week.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with melphalan and dexamethasone to patients with amyloidosis. In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, and steroids can be administered to patients with amyloidosis.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with gemcitabine and cisplatinum to patients with locally advanced or metastatic transitional cell bladder cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with a second active ingredient as follows: temozolomide to pediatric patients with relapsed or progressive brain tumors or recurrent neuroblastoma; celecoxib, etoposide and cyclophosphamide for relapsed or progressive CNS cancer; temodar to patients with recurrent or progressive meningioma, malignant meningioma, hemangiopericytoma, multiple brain metastases, relapased brain tumors, or newly diagnosed glioblastoma multiforms; irinotecan to patients with recurrent glioblastoma; carboplatin to pediatric patients with brain stem glioma; procarbazine to pediatric patients with progressive malignant gliomas; cyclophosphamide to patients with poor prognosis malignant brain tumors, newly diagnosed or recurrent glioblastoma multiforms; Gliadel® for high grade recurrent malignant gliomas; temozolomide and tamoxifen for anaplastic astrocytoma; or topotecan for gliomas, glioblastoma, anaplastic astrocytoma or anaplastic oligodendroglioma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with methotrexate, cyclophosphamide, taxane, abraxane, lapatinib, herceptin, aromatase inhibitors, selective estrogen modulators, estrogen receptor antagonists, and/or PLX3397 (Plexxikon) to patients with metastatic breast cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with temozolomide to patients with neuroendocrine tumors.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with gemcitabine to patients with recurrent or metastatic head or neck cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with gemcitabine to patients with pancreatic cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with colon cancer in combination with ARISA®, avastatin, taxol, and/or taxotere.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with capecitabine and/or PLX4032 (Plexxikon) to patients with refractory colorectal cancer or patients who fail first line therapy or have poor performance in colon or rectal adenocarcinoma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with fluorouracil, leucovorin, and irinotecan to patients with Dukes C & D colorectal cancer or to patients who have been previously treated for metastatic colorectal cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with refractory colorectal cancer in combination with capecitabine, xeloda, and/or CPT-11.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with capecitabine and irinotecan to patients with refractory colorectal cancer or to patients with unresectable or metastatic colorectal carcinoma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered alone or in combination with interferon alpha or capecitabine to patients with unresectable or metastatic hepatocellular carcinoma; or with cisplatin and thiotepa to patients with primary or metastatic liver cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with pegylated interferon alpha to patients with Kaposi's sarcoma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with fludarabine, carboplatin, and/or topotecan to patients with refractory or relapsed or high-risk acuted myelogenous leukemia.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with liposomal daunorubicin, topotecan and/or cytarabine to patients with unfavorable karotype acute myeloblastic leukemia.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with gemcitabine, abraxane, erlotinib, geftinib, and/or irinotecan to patients with non-small cell lung cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with carboplatin and irinotecan to patients with non-small cell lung cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered with doxetaxol to patients with non-small cell lung cancer who have been previously treated with carbo/VP 16 and radiotherapy.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with carboplatin and/or taxotere, or in combination with carboplatin, paclitaxel and/or thoracic radiotherapy to patients with non-small cell lung cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with taxotere to patients with stage IIIB or IV non-small cell lung cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with oblimersen (Genasense®) to patients with small cell lung cancer.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with ABT-737 (Abbott Laboratories) and/or obatoclax (GX15-070) to patients with lymphoma and other blood cancers.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered alone or in combination with a second active ingredient such as vinblastine or fludarabine to patients with various types of lymphoma, including, but not limited to, Hodgkin's lymphoma, non-Hodgkin's lymphoma, cutaneous T-Cell lymphoma, cutaneous B-Cell lymphoma, diffuse large B-Cell lymphoma or relapsed or refractory low grade follicular lymphoma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with taxotere, IL-2, IFN, GM-CSF, PLX4032 (Plexxikon) and/or dacarbazine to patients with various types or stages of melanoma.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered alone or in combination with vinorelbine to patients with malignant mesothelioma, or stage IIIB non-small cell lung cancer with pleural implants or malignant pleural effusion mesothelioma syndrome.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of multiple myeloma in combination with dexamethasone, zoledronic acid, palmitronate, GM-CSF, biaxin, vinblastine, melphalan, busulphan, cyclophosphamide, IFN, palmidronate, prednisone, bisphosphonate, celecoxib, arsenic trioxide, PEG INTRON-A, vincristine, or a combination thereof.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with relapsed or refractory multiple myeloma in combination with doxorubicin (Doxil®), vincristine and/or dexamethasone (Decadron®).

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of ovarian cancer such as peritoneal carcinoma, papillary serous carcinoma, refractory ovarian cancer or recurrent ovarian cancer, in combination with taxol, carboplatin, doxorubicin, gemcitabine, cisplatin, xeloda, paclitaxel, dexamethasone, or a combination thereof.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of prostate cancer, in combination with xeloda, 5 FU/LV, gemcitabine, irinotecan plus gemcitabine, cyclophosphamide, vincristine, dexamethasone, GM-CSF, celecoxib, taxotere, ganciclovir, paclitaxel, adriamycin, docetaxel, estramustine, Emcyt, denderon or a combination thereof.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of renal cell cancer, in combination with capecitabine, IFN, tamoxifen, IL-2, GM-CSF, Celebrex®, or a combination thereof.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of gynecologic, uterus or soft tissue sarcoma cancer in combination with IFN, a COX-2 inhibitor such as Celebrex®, and/or sulindac.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with various types or stages of solid tumors in combination with celebrex, etoposide, cyclophosphamide, docetaxel, apecitabine, IFN, tamoxifen, IL-2, GM-CSF, or a combination thereof.

In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with scleroderma or cutaneous vasculitis in combination with celebrex, etoposide, cyclophosphamide, docetaxel, apecitabine, IFN, tamoxifen, IL-2, GM-CSF, or a combination thereof.

Also encompassed herein is a method of increasing the dosage of an anti-cancer drug or agent that can be safely and effectively administered to a patient, which comprises administering to the patient (e.g., a human) or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Patients that can benefit by this method are those likely to suffer from an adverse effect associated with anti-cancer drugs for treating a specific cancer of the skin, subcutaneous tissue, lymph nodes, brain, lung, liver, bone, intestine, colon, heart, pancreas, adrenal, kidney, prostate, breast, colorectal, or combinations thereof. The administration of a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, alleviates or reduces adverse effects which are of such severity that it would otherwise limit the amount of anti-cancer drug.

In one embodiment, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered orally and daily in an amount ranging from about 0.1 to about 150 mg, from about 1 to about 50 mg, or from about 2 to about 25 mg, prior to, during, or after the occurrence of the adverse effect associated with the administration of an anti-cancer drug to a patient. In certain embodiments, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered in combination with specific agents such as heparin, aspirin, coumadin, or G-CSF to avoid adverse effects that are associated with anti-cancer drugs such as but not limited to neutropenia or thrombocytopenia.

In one embodiment, a compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, is administered to patients with diseases and disorders associated with or characterized by, undesired angiogenesis in combination with additional active ingredients, including, but not limited to, anti-cancer drugs, anti-inflammatories, antihistamines, antibiotics, and steroids.

In another embodiment, encompassed herein is a method of treating, preventing and/or managing cancer, which comprises administering a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, in conjunction with (e.g. before, during, or after) conventional therapy including, but not limited to, surgery, immunotherapy, biological therapy, radiation therapy, or other non-drug based therapy presently used to treat, prevent or manage cancer. The combined use of the compound provided herein and conventional therapy may provide a unique treatment regimen that is unexpectedly effective in certain patients. Without being limited by theory, it is believed that a compound provided herein may provide additive or synergistic effects when given concurrently with conventional therapy. In certain embodiments provided herein is a compound provided herein for use in a method of treating, preventing and/or managing cancer, wherein the method comprises the above defined administration step.

As discussed elsewhere herein, encompassed herein is a method of reducing, treating and/or preventing adverse or undesired effects associated with conventional therapy including, but not limited to, surgery, chemotherapy, radiation therapy, hormonal therapy, biological therapy and immunotherapy. Also encompassed herein is a compound provided herein for use in a method of reducing, treating and/or preventing adverse or undesired effects associated with conventional therapy including, but not limited to, surgery, chemotherapy, radiation therapy, hormonal therapy, biological therapy and immunotherapy. A compound provided herein, e.g., a compound provided herein, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, and other active ingredient can be administered to a patient prior to, during, or after the occurrence of the adverse effect associated with conventional therapy.

In one embodiment, a compound provided herein can be administered in an amount ranging from about 0.1 to about 150 mg, from about 1 to about 25 mg, or from about 2 to about 10 mg orally and daily alone, or in combination with a second active agent disclosed herein (see, e.g., section 5.4), prior to, during, or after the use of conventional therapy.

The following examples are offered by way of illustration, and not by way of limitation.

6. EXAMPLES 6.1 Preparation of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (Lenalidomide) Methyl 2-bromomethyl-3-nitrobenzoate

A stirred mixture of methyl 2-methyl-3-nitrobenzoate (14.0 g, 71.7 mmol) and N-bromosuccinimide (15.3 g, 86.1 mmol) in carbon tetrachloride (200 mL) was heated under gentle reflux for 15 hours while a 100W bulb situated 2 cm away was shining on the flask. The mixture was filtered and the solid was washed with methylene chloride (50 mL). The filtrate was washed with water (2×100 mL), brine (100 mL) and dried. The solvent was removed in vacuo and the residue was purified by flash chromatography (hexane/ethyl acetate, 8/2) to afford 19 g (96%) of the product as a yellow solid: mp 70.0-71.5° C.; 1H NMR (CDCl₃) δ 8.12-8.09 (dd, J=1.3 and 7.8 Hz, 1H), 7.97-7.94 (dd, J=1.3 and 8.2 Hz, 1H), 7.54 (t, J=8.0 Hz, 1H), 5.15 (s, 2H), 4.00 (s, 3H); ¹³C NMR (CDCl₃) δ 165.85, 150.58, 134.68, 132.38, 129.08, 127.80, 53.06, 22.69; HPLC, Water Nove-Pak/C18, 3.9×150 mm, 4 micron, 1 mL/min, 240 nm, 40/60 CH₃CN/0.1% H₃PO₄(aq) 7.27 min(98.92%); Anal. Calcd for C₉H₈NO₄Br: C, 39.44; H, 2.94; N, 5.11; Br, 29.15. Found: C, 39.46; H, 3.00; N, 5.00; Br, 29.11.

t-Butyl N-(1-oxo-4-nitroisoindolin-2-yl)-L-glutamine

Triethylamine (2.9 g, 28.6 mmol) was added dropwise to a stirred mixture of methyl 2-bromomethyl-3-nitrobenzoate (3.5 g, 13.0 mmol) and L-glutamine t-butyl ester hydrochloride (3.1 g, 13.0 mmol) in tetrahydrofuran (90 mL). The mixture was heated to reflux for 24 hours. To the cooled mixture was added methylene chloride (150 mL) and the mixture was washed with water (2×40 mL), brine (40 mL) and dried. The solvent was removed in vacuo and the residue was purified by flash chromatography (3% CH₃OH in methylene chloride) to afford 2.84 g (60%) of crude product which was used directly in the next reaction: 1H NMR (CDCl₃) δ 8.40 (d, J=8.1 Hz, 1H), 8.15 (d, J=7.5 Hz, 1H), 7.71 (t, J=7.8 Hz, 1H), 5.83 (s, 1H), 5.61 (s, 1H), 5.12 (d, J=19.4 Hz, 1H), 5.04-4.98 (m, 1H), 4.92 (d, J=19.4 Hz, 1H), 2.49-2.22 (m, 4H), 1.46 (s, 9H); HPLC, Waters Nova-Pak C18, 3.9×150 mm, 4 micron, 1 mL/min, 240 nm, 25/75 CH₃CN/0.1% H₃PO₄(aq) 6.75 min(99.94%).

N-(1-oxo-4-nitroisoindolin-2-yl)-L-glutamine

Hydrogen chloride gas was bubbled into a stirred 5° C. solution of t-butyl N-(1-oxo-4-nitro-isoindolin-2-yl)-L-glutamine (3.6 g, 9.9 mmol) in methylene chloride (60 mL) for 1 hour. The mixture was then stirred at room temperature for another hour. Ether (40 mL) was added and the resulting mixture was stirred for 30 minutes. The slurry was filtered, washed with ether and dried to afford 3.3 g of the product: 1H NMR (DMSO-d₆) δ 8.45 (d, J=8.1 Hz, 1H), 8.15 (d, J=7.5 Hz, 1H), 7.83 (t, J=7.9 Hz, 1H), 7.24 (s, 1H), 6.76 (s, 1H), 4.93 (s, 2H), 4.84-4.78 (dd, J=4.8 and 10.4 Hz, 1H), 2.34-2.10 (m, 4H); ¹³C NMR (DMSO-d₆) δ 173.03, 171.88, 165.96, 143.35, 137.49, 134.77, 130.10, 129.61, 126.95, 53.65, 48.13, 31.50, 24.69; Anal. Calcd for C₁₃H₁₃N₃O₆: C, 50.82; H, 4.26; N, 13.68. Found: C, 50.53; H, 4.37; N, 13.22.

(S)-3-(1-oxo-4-nitroisoindolin-2-yl)piperidine-2,6-dione

A stirred suspension mixture of N-(1-oxo-4-nitroisoindolin-2-yl)-L-glutamine (3.2 g, 10.5 mmol) in anhydrous methylene chloride (150 mL) was cooled to −40° C. with isopropanol/dry ice bath. Thionyl chloride (0.82 mL, 11.3 mmol) was added dropwise to the cooled mixture followed by pyridine (0.9 g. 11.3 mmol). After 30 min, triethylamine (1.2 g, 11.5 mmol) was added and the mixture was stirred at −30 to −40° C. for 3 hours. The mixture was poured into ice water (200 mL) and the aqueous layer was extracted with methylene chloride (40 mL). The methylene chloride solution was washed with water (2×60 mL), brine (60 mL) and dried. The solvent was removed in vacuo and the solid residue was slurried with ethyl acetate (20 mL) to give 2.2 g (75%) of the product as a white solid: mp 285° C.; 1H NMR (DMSO-d₆) δ: 1.04 (s, 1H), 8.49-8.45 (dd, J=0.8 and 8.2 Hz, 1H), 8.21-8.17 (dd, J=7.3 Hz, 1H), 7.84 (t, J=7.6 Hz, 1H), 5.23-5.15 (dd, J=4.9 and 13.0 Hz, 1H), 4.96 (dd, J=19.3 and 32.4 Hz, 2H), 3.00-2.85 (m, 1H), 2.64-2.49 (m, 2H), 2.08-1.98 (m, 1H); ¹³C NMR (DMSO-d₆) δ 172.79, 170.69, 165.93, 143.33, 137.40, 134.68, 130.15, 129.60, 127.02, 51.82, 48.43, 31.16. 22.23; HPLC, Waters Nove-Pak/C18, 3.9×150 mm, 4 micron, 1 mL/min, 240 nm, 20/80 CH₃CN/0.1% H₃PO₄(aq) 3.67 min(100%); Anal. Calcd for C₁₃H_(n)N₃O₅: C, 53.98; H, 3.83; N, 14.53. Found: C, 53.92; H, 3.70; N, 14.10.

3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

A mixture of (S)-3-(1-oxo-4-nitroisoindolin-2-yl)piperidine-2,6-dione (1.0 g, 3.5 mmol) and 10% Pd/C (0.3 g) in methanol (600 mL) was hydrogenated in a Parr-Shaker apparatus at 50 psi of hydrogen for 5 hours. The mixture was filtered through Celite and the filtrate was concentrated in vacuo. The solid was slurried in hot ethyl acetate for 30 min, filtered and dried to afford 0.46 g (51%) of the product as a white solid: mp 235.5-239° C.; ¹H NMR (DMSO-d₆) δ 11.01 (s, 1H), 7.19 (t, J=7.6 Hz, 1H), 6.90 (d. J=7.3 Hz, 1H), 6.78 (d, J=7.8 Hz, 1H), 5.42 (s, 2H), 5.12 (dd. J=5.1 and 13.1 Hz, 1H), 4.17 (dd, J=17.0 and 28.8 Hz, 2H), 2.92-2.85 (m, 1H), 2.64-2.49 (m, 1H), 2.34-2.27 (m, 1H), 2.06-1.99 (m, 1H); ¹³C NMR (DMSO-d₆) δ 172.85, 171.19, 168.84, 143.58, 132.22. 128.79, 125.56, 116.37, 110.39, 51.48, 45.49, 31.20, 22.74; HPLC. Waters Nova-Pak/C18, 3.9×150 mm, 4 micron, 1 mL/min, 240 nm, 10/90 CH₃CN/0.1% H₃PO₄(aq) 0.96 min(100%); Chiral analysis, Daicel Chiral Pak AD, 40/60 Hexane/IPA, 6.60 min(99.42%); Anal. Calcd for C₁₃H₁₃N₃O₃: C, 60.23; H, 5.05; N, 16.21. Found: C, 59.96; H, 4.98; N, 15.84.

3-(4-Amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione may also be prepared by methods known in the art, for example, as provided in Drugs of the Future, 2003, 28(5): 425-431, the entirety of which is incorporated by reference.

6.2 Preparation of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (Compound A)

To a solution of potassium hydroxide (16.1 g, 286 mmol) in water (500 mL), was added 3-nitrophthalimide (25.0 g, 130 mmol) in portion at 0° C. The suspension was stirred at 0° C. for 3 hrs, and then heated to 30° C. for 3 hrs. To the solution, was added HCl (100 mL, 6N). The resulting suspension was cooled to 0° C. for 1 hr. The suspension was filtered and washed with cold water (2×10 mL) to give 3-nitro-phthalamic acid as a white solid (24.6 g, 90% yield): ¹H NMR (DMSO-d₆) δ 7.69 (brs, 1H, NHH), 7.74 (t, J=8 Hz, 1H, Ar), 7.92 (dd, J=1, 8 Hz, 1H, Ar), 8.13 (dd, J=1, 8 Hz, 1H, Ar), 8.15 (brs, 1H, NHH), 13.59 (s, 1H, OH); ¹³C NMR (DMSO-d₆) δ 125.33, 129.15, 130.25, 132.54, 136.72, 147.03, 165.90, 167.31.

To a mixture of 3-nitro-phthalamic acid (24.6 g, 117 mmol) and potassium hydroxide (6.56 g, 117 mmol) in water (118 mL), was added a mixture of bromine (6 mL), potassium hydroxide (13.2 g, 234 mmol) in water (240 mL) at 0° C., followed by addition of a solution of potassium hydroxide (19.8 g, 351 mmol) in water (350 mL). After 5 minutes at 0° C., the mixture was heated in a 100° C. oil bath for 1 hr. The reaction solution was cooled to room temperature, and then, in an ice-water bath for 30 minutes. To the mixture, a solution of HCl (240 mL, 2N) was added dropwise at 0° C., and the resulting mixture was kept for 1 hr. The suspension was filtered and washed with water (5 mL) to give 2-amino-6-nitro-benzoic acid as yellow solid (15.6 g, 73% yield): HPLC: Waters Symmetry C₁₈, 5 μm, 3.9×150 mm, 1 mL/min, 240 nm, CH₃CN/0.1% H₃PO₄, 5% grad to 95% over 5 min, 5.83 min (85%); ¹H NMR (DMSO-d₆) δ 6.90 (dd, J=1, 8 Hz, 1H, Ar), 7.01 (dd, J=1, 9 Hz, 1H, Ar), 7.31 (t, J=8 Hz, 1H, Ar), 8.5-9.5 (brs, 3H, OH, NH₂); ¹³C NMR (DMSO-d₆) δ 105.58, 110.14, 120.07, 131.74, 149.80, 151.36, 166.30; LCMS: MH=183.

A mixture of 2-amino-6-nitro-benzoic acid (1.5 g, 8.2 mmol) in acetic anhydride (15 mL) was heated at 200° C. for 30 minutes in a microwave oven. The mixture was filtered and washed with ethyl acetate (20 mL). The filtrate was concentrated in vacuo. The solid was stirred in ether (20 mL) for 2 hrs. The suspension was filtered and washed with ether (20 mL) to give 2-methyl-5-nitro-benzo[d][1,3]oxazin-4-one as a light brown solid (1.4 g, 85% yield): HPLC: Waters Symmetry C₁₈, 5 μm, 3.9×150 mm, 1 mL/min, 240 nm, CH₃CN/0.1% H₃PO₄, 5% grad 95% in 5 min, 5.36 min (92%); ¹H NMR (DMSO-d₆) δ 2.42 (s, 3H, CH₃), 7.79 (dd, J=1, 8 Hz, 1H, Ar), 7.93 (dd, J=1, 8 Hz, 1H, Ar), 8.06 (t, J=8 Hz, 1H, Ar); ¹³C NMR (DMSO-d₆) δ 20.87, 107.79, 121.54, 128.87, 137.19, 147.12, 148.46, 155.18, 161.78; LCMS: MH=207.

Two vials each with a suspension of 5-nitro-2-methyl-benzo[d][1,3]oxazin-4-one (0.60 g, 2.91 mmol) and 3-amino-piperidine-2,6-dione hydrogen chloride (0.48 g, 2.91 mmol) in pyridine (15 mL) were heated at 170° C. for 10 minutes in a microwave oven. The suspension was filtered and washed with pyridine (5 mL). The filtrate was concentrated in vacuo. The resulting mixture was stirred in HCl (30 mL, 1N), ethyl acetate (15 mL) and ether (15 mL) for 2 hrs. The suspension was filtered and washed with water (30 mL) and ethyl acetate (30 mL) to give a dark brown solid, which was stirred with methanol (50 mL) at room temperature overnight. The suspension was filtered and washed with methanol to give 3-(2-methyl-5-nitro-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione as a black solid (490 mg, 27% yield). The solid was used in the next step without further purification.

A mixture of 3-(2-methyl-5-nitro-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (250 mg) and Pd(OH)₂ on carbon (110 mg) in DMF (40 mL) was shaken under hydrogen (50 psi) for 12 hrs. The suspension was filtered through a pad of Celite and washed with DMF (10 mL). The filtrate was concentrated in vacuo and the resulting oil was purified by flash column chromatography (silica gel, methanol/methylene chloride) to give 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione as a white solid (156 mg, 69% yield): HPLC: Waters Symmetry C₁₈, 5 μm, 3.9×150 mm, 1 mL/min, 240 nm, 10/90 CH₃CN/0.1% H₃PO₄, 3.52 min (99.9%); mp: 293-295° C.; ¹H NMR (DMSO-d₆) δ 2.10-2.17 (m, 1H, CHH), 2.53 (s, 3H, CH₃), 2.59-2.69 (m, 2H, CH₂), 2.76-2.89 (m, 1H, CHH), 5.14 (dd, J=6, 11 Hz, 1H, NCH), 6.56 (d, J=8 Hz, 1H, Ar), 6.59 (d, J=8 Hz, 1H, Ar), 7.02 (s, 2H, NH₂), 7.36 (t, J=8 Hz, 1H, Ar), 10.98 (s, 1H, NH); ¹³C NMR (DMSO-d₆) δ 20.98, 23.14, 30.52, 55.92, 104.15, 110.48, 111.37, 134.92, 148.17, 150.55, 153.62, 162.59, 169.65, 172.57; LCMS: MH=287; Anal. Calcd. for C₁₄H₁₄N₄O₃+0.3H₂O: C, 57.65; H, 5.05; N, 19.21. Found: C, 57.50; H, 4.73; N, 19.00.

6.3 Unbound CRBN Crystal Structure

This example describes the preparation of a CRBN crystal. Cereblon immunomodulatory agent-binding domain can be purified as follows: The gene encoding the thalidomide binding domain (TBD) of human CRBN (amino acids 319-427) or mouse CRBN (amino acids 322-430) is codon optimized and inserted into a pGEX6P-3 vector for expression as a GST-fusion protein in E. coli. BL21 (DE3) Star cells transformed with either plasmid are grown to OD 0.6 in TB media supplemented with 50 μM zinc acetate, and induced with 0.5 mM IPTG for 4 hours at 37 C. Cells are resuspended in lysis buffer containing 50 mM Tris pH 7, 150 mM NaCl, 10% glycerol, 2 mM TECP, 1 mM DTT, 100 U/mL benzonase (Novagen), 1× Protease Inhibitor Cocktail-EDTA free (SD Biosciences), 0.5 mg/mL lysozyme (Sigma), and sonicated for 30 s before ultracentrifuation for 30 min at 100,000×g. GST-fused CRBN is then bound to glutathione affinity resin, washed in 50 mM Tris pH 7, 150 mM NaCl, 10% glycerol, 2 mM TCEP, 1 mM DTT, and eluted in the same buffer with the addition of 40 mM reduced glutathione. The GST tag is removed by overnight cleavage at 4 C with PreScission™ Protease (1U/mg protein, GE Healthcare). CRBN TBD is further purified with ion-exchange chromatography by diluting the cleaved protein to 75 mM NaCl usign 50 mM Tris pH 7, 2 mM TCEP and 1 mM DTT, and binding to either a Mono S column (mouse TBD) or heparin column (human TBD). Protein is eluted using a gradient from 90 mM to 1M NaCl and pooled for size exclusion chromatography. Mouse CRBN TBD can be purified by size exclusion over an S75 16/600 in 5 mM sodium acetate pH 6, 10 mM TECP, and 5 mM DTT. Human CRBN TBD can be purified over an S75 16/600 in 20 mM MES pH 6, 200 mM NaCl, 10 mM TCEP and 1 mM DTT. Either the human or the mouse protein can be concentrated to 17 mg/mL. Alternatively, residues of murine 321-429 fused to GST can be expressed in E. coli. Cells are lysed by sonication and the soluble fraction purified using GST-trap, ion exchange and size-exclusion chromatography. Protein can be concentrated to 28 mg/ml in 50 mM acetate buffer, pH 6.0, 1 mM DTT, 10 mM TCEP. Crystals can be obtained by sitting drop vapor diffusion by mixing the protein buffer 1:1 with and equilibrating against a mother liquor of crystallization buffer. For the mouse unbound TBD, the crystallization buffer contains 100 mM Sodium acetate pH 5, 600-800 mM Ammonium sulfate. Crystals can be grown at 4 degrees centrigrade and cryoprotected by addition of 20% glycerol and frozen under liquid nitrogen.

6.4 CRBN-Drug Complex Crystal Structures

This example describes the preparation of a crystal of CRBN complexed with a second compound used to study structure-activity relationships.

A crystal of CRBN complexed with a Apo was prepared and used as a negative control. In addition, a crystal of CRBN complexed with thalidomide, pomalidomide, Compound B, or Compound C was prepared.

FIG. 2 depicts identical projections of certain CMA binding surfaces of CRBN and shows protein conformational changes.

FIG. 3A depicts the crystal structure of CRBN prior to Compound B binding, and FIG. 3B depicts the crystal structure of Compound B in CRBN, in which the drug can act as a “molecular glue” or bridge with a substrate, such as a CRBN-associated protein.

FIG. 4 depicts a complex of CRBN and Compound B or thalidomide. A 50° rotation of “pthalimide” ring in Compound B relative to thalidomide or pomalidomide is observed. Such a rotation can allows for different biological effects downstream, as well as the resulting therapeutic effects.

6.5 Aiolos Degradation Assay for Identification of CMAs

The example describes an exemplary method for assaying a CRBN-mediated biological activity, and specifically Aiolos degradation.

Immunohistochemistry is performed using standard methods. For example, Immunohistochemistry is performed on the Bond-Max® automated slide stainer (Leica Microsystems) using the associated Bond Polymer Refine® Detection Kit. Four micron thick FFPE sections are deparaffinized on the instrument. Antigen retrieval is performed with Epitope Retrieval™ 2 (pH 9.0) for 20 minutes at 100° C. The slides are blocked for endogenous peroxidase activity with Peroxide Block for 5 minutes at room temperature. Sections are then incubated with rabbit polyclonal antibody to Aiolos (Santa Cruz, sc-101982) at a 1/1000 dilution for 15 minutes at room temperature, followed by incubation with HRP labeled Polymer for 8 minutes at room temperature. Enzymatic detection of anti-Aiolos antibody is accomplished with hydrogen peroxide substrate and diaminobenzidine tetrahydrochloride (DAB) chromogen at room temperature for 10 minutes. Slides are counterstained with Hematoxylin for 5 minutes at room temperature.

6.6 Production of Compound C Analogs

This example describes the production of Compound C, and analogs thereof.

1-(3-Chloro-4-methyl-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea

Step 1:

A mechanically stirred mixture of 4-bromo-2-methyl-benzoic acid (100 g, 465 mmol), iodomethane (95 g, 670 mmol) and sodium bicarbonate (112 g, 1340 mmol) in DMF (325 mL) was heated at 80° C. overnight. The reaction mixture was cooled to room temperature and partitioned between water (1500 mL) and 4:1 hexanes:ethyl acetate (1500 mL). The organic layer was washed with water and dried (Na₂SO₄). The solvent was removed under vacuum to give 110 g of 4-bromo-2-methyl-benzoic acid methyl ester as an oil, in 100% yield; ¹H NMR (DMSO-d₆) δ 2.51 (s, 3H), 3.84 (s, 3H), 7.40-7.78 (m, 3H).

Step 2:

A mechanically stirred mixture of 4-bromo-2-methyl-benzoic acid methyl ester (115 g, 500 mmol), N-bromosuccinimide (90 g, 500 mmol) and AIBN (3.1 g) in acetonitrile (700 mL) was warmed over 45 minutes to a gentle reflux, and held at reflux for 21 hours. The reaction mixture was cooled to room temperature, diluted with saturated aqueous sodium bisulfite, and concentrated in vacuo. The residue was partitioned between water and 1:1 hexanes:ethyl acetate. The organic phase was washed with water, brine, and filtered through a pad of silica gel. The solvent was removed under vacuum to give an oil/solid mixture, which was digested in ether and filtered. The filtrate was chromatographed on silica gel using a hexanes-ethyl acetate gradient, eluting the product at 4:1 hexanes-ethyl acetate and providing 102 g of 4-bromo-2-bromomethyl-benzoic acid methyl ester, in 66% yield; ¹H NMR (DMSO-d₆) δ 3.87 (s, 3H), 4.99 (s, 2H), 7.67-7.97 (m, 3H).

Step 3:

A mechanically stirred mixture of 4-bromo-2-bromomethyl-benzoic acid methyl ester (121 g, 390 mmol) and 3-amino-piperidine-2,6-dione hydrochloride (64.2 g, 390 mmol) in DMF (400 mL) was treated dropwise with triethylamine (98.5 g, 980 mmol) over 75 minutes. After the addition was completed, the reaction mixture was stirred at room temperature overnight. The mixture was quenched sequentially with acetic acid (50 mL), water (2500 mL) and a 1:1 mixture of ethyl acetate and hexanes (600 mL). After stirring the mixture for 20 minutes, the solid was filtered, washed with water and air dried overnight. The solid was stirred in acetic acid (200 mL) and refluxed for 2 hours. The mixture was cooled to room temperature and filtered. The solid was washed with additional acetic acid, hexanes and air dried overnight to give 25.4 g of 3-(5-bromo-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione as a grey solid, in 20% yield; ¹H NMR (DMSO-d₆) δ 1.97-2.04 (m, 1H), 2.32-2.46 (m, 1H), 2.56-2.63 (m, 1H), 2.85-2.97 (m, 1H), 4.34 (d, J=17.7 Hz, 1H), 4.47 (d, J=17.7 Hz, 1H), 5.11 (dd, J=13.2 Hz, J=5.1 Hz, 1H), 7.67 (d, J=8.1 Hz, 1H), 7.72 (dd, J=8.1 Hz, J=1.5 Hz, 1H), 7.89 (d, J=0.9 Hz, 1H), 11.00 (s, 1H).

Step 4:

A mechanically stirred mixture of 3-(5-bromo-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (25.2 g, 78 mmol), bis(diphenylphosphino)ferrocene (2.0 g), tris(dibenzylideneacetone)dipalladium (2.0 g) and zinc cyanide (9.4 g, 80 mmol) in DMF (300 mL) was heated to 120° C. and stirred at this temperature for 19 hours. The reaction mixture was cooled to 40° C., and another 9.4 g of zinc cyanide, 2 g of bis(diphenylphosphino)ferrocene and 2 g of tris(dibenzylideneacetone)dipalladium were added. The mixture was stirred at 120° C. for 2 hours, cooled to room temperature and quenched with water (900 mL). The solid was filtered, washed with additional water and air dried overnight. The solid was stirred in hot acetic acid (200 mL) for 20 minutes. The solid was filtered, washed with additional acetic acid, ethyl acetate and hexanes, and air dried to give 30.8 g of crude 2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindole-5-carbonitrile as a gray solid; ¹H NMR (DMSO-d₆) δ 1.99-2.06 (m, 1H), 2.35-2.45 (m, 1H), 2.57-2.63 (m, 1H), 2.86-2.98 (m, 1H), 4.42 (d, J=17.7 Hz, 1H), 4.55 (d, J=17.7 Hz, 1H), 5.15 (dd, J=13.2 Hz, J=5.1 Hz, 1H), 7.91 (d, J=7.8 Hz, 1H), 7.99 (dd, J=7.8 Hz, J=0.9 Hz, 1H), 8.16 (s, 1H), 11.03 (s, 1H).

Step 5:

A mixture of 2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindole-5-carbonitrile (9.2 g, 34 mmol), 10% Pd-C (1.7 g) and concentrated HCl (5.3 g) in N-methylpyrrolidone (300 mL) was hydrogenated at 58 psi overnight. The crude reaction mixture was filtered through Celite, and the catalyst washed with water. The combined filtrate was concentrated in vacuo, and the product, 3-(5-aminomethyl-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione hydrochloride, was isolated by fractional crystallization of the residue from isopropanol-water (1.9 g, 18%); ¹H NMR (DMSO-d₆) δ 1.85-2.20 (m, 1H), 2.35-2.45 (m, 1H), 2.58-2.80 (m, 1H), 2.87-2.99 (m, 1H), 4.16 (s, 2H), 4.35 (d, J=17.5 Hz, 1H), 4.49 (d, J=17.5 Hz, 1H), 5.13 (dd, J=13.2 Hz, J=4.8 Hz, 1H), 7.63 (d, J=7.8 Hz, 1H), 7.72 (s, 1H), 7.79 (d, J=7.8 Hz, 1H), 8.43 (br, 3H), 11.01 (s, 1H).

Step 6:

A mixture of 3-(5-aminomethyl-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione hydrochloride (0.50 g, 1.6 mmol), 3-chloro-4-methylphenyl isocyanate (0.27 g, 1.6 mmol) and TEA (0.32 g, 3.2 mmol) in THF (25 mL) was heated to 40° C. with stirring under N₂. After 3 hours, an additional portion of 3-chloro-4-methylisocyanate (0.17 g, 1.1 mmol) was added, and stirring proceeded for 2 hours. The mixture was filtered, and the filter was washed with ethyl acetate. The solid was triturated with 10 mL of 1:1 acetone-DMF and filtered. The filter was washed with acetone, and the solid was dried under vacuum, providing 430 mg of the product, in 60% yield; mp 258-260° C.; HPLC, Waters Symmetry C-18, 3.9×150 mm, 5 μm, 1 mL/min, 240 nm, 40/60 CH₃CN/0.1% H₃PO₄, 4.49 (98.75%); ¹H NMR (DMSO-d₆) δ 1.90-1.96 (m, 1H), 2.16 (s, 3H), 2.25-2.39 (m, 1H), 2.50-2.55 (m, 1H), 2.78-2.91 (m, 1H), 4.24 (d, J=18.0 Hz, 1H), 4.33-4.41 (m, 3H), 5.04 (dd, J=13.5 Hz, J=4.5 Hz, 1H), 6.73 (t, J=6.0 Hz, 1H), 7.04-7.13 (m, 2H), 7.36-7.44 (m, 2H), 7.59-7.44 (m, 2H), 8.69 (s, 1H), 10.92 (s, 1H); ¹³C NMR (DMSO-d₆) δ 18.7, 22.5, 31.2, 42.8, 47.1, 51.5, 116.4, 117.6, 121.9, 122.9, 126.9, 127.4, 130.3, 131.0, 133.0, 139.6, 142.4, 144.7, 155.1, 167.9, 171.0, 172.9; Anal. Calcd for C₂₂H₂₁ClN₄O₄: C, 59.93; H, 4.80; N, 12.71. Found: C, 59.77; H, 4.61; N, 12.69.

6.7 CRBN is Required for the Anti-Proliferative Effect of Compound C in Hematological and Solid Tumors Lenalidomide Competes with Compound A and Compound C for CRBN

TMD8 (ABC) or Karpas 422 (GCB) cells were treated with either lenalidomide; Compound A; Compound A and 100 μM lenalidomide, Compound C; or Compound C and 100 lenalidomide. Cells were cultured and cell-passaged long-term in lenalidomide or Compound A. The cells were then analyzed for proliferation using a ³H-thymidine incorporation assay.

FIG. 5 shows that lenalidomide competes with Compound A and Compound C for CRBN. FIG. 5A shows that co-treatment with Compound A and 10 μM lenalidomide blocks anti-proliferative effects of Compound A, though competition of binding to the CRBN complex. Likewise, FIG. 5B shows that co-treatment with Compound C and 10 μM lenalidomide blocks anti-proliferative effects of Compound C, though competition of binding to the CRBN complex. Co-culture of Lenalidomide with either Compound A or Compound C dampens the activity of these compounds as they target the same binding pocket with relative affinity.

6.8 Effect of Compound C Analogs on CRBN Substrates

This example shows the effects of Compound C analogs on CRBN substrates.

6.8.1. Compound C Induces Early Apoptosis in the MM Cell Line 11929

The multiple myeloma cell line, H929, was cultured and treated with Compound C or other CMA analogs at various concentrations from 0.01 nM to 1000 nM. Apoptosis was assessed at 24 hrs. later.

As shown in FIG. 6, Compound C induced early apoptosis in the multiple myeloma (MM) cell line H929, whereas other CMAs did not.

6.8.2. Compound C is Potent Across a Panel of Solid Tumor Lines

The potency of Compound C was assessed across a panel of tumor cell lines, including B-lymphoma, breast, CNS, colon, kidney, leukemia, lung, melanoma, multiple myeloma, ovary and prostate.

As shown in FIG. 7, Compound C is potent across a panel of tumor lines. While there was a differential cytotoxicity across the cancer cell panel, Compound C had an overall low Therapeutic Index (i.e., toxic effects at low doses). Of note, traditional immunomodulatory agents have no activity in solid tumor cell lines.

6.8.3. CRBN is Required for Anti-Proliferative Activity of Compound C in MM Cells

Next, it was determined if Compound C binds CRBN in U266 multiple myeloma cells, and whether CRBN was required for Compound C activity in those cells.

As shown in FIG. 8, Compound C binds CRBN protein MM cell extracts. Immunoblot analysis of extracts prepared from U266 multiple myeloma cells and pre-incubated with vehicle DMSO (D), Pomalidomide (Pom) or Compound C at the indicated concentrations, and bound to thalidomide analog affinity beads, washed and eluted with SDS buffer as previously described (Ito et al, 2010; Lopez-Girona et al, 2012). Samples were subjected to SDS-PAGE and immunoblot analysis using anti-CRBN 65-76 (1:10,000 dilution; Red signal) and anti-DDB1 (Cell Signaling) (1:2,000 dilution; Green signal). A LI-COR Odissey system was used to quantify CRBN band density and relative amounts of CRBN were determined by averaging at least three DMSO controls and expressing CRBN in each competition sample as percent inhibition of CRBN protein relative to the averaged controls as 100% binding. Moreover, FIGS. 9 and 10 show that CRBN is required for the anti-proliferative activity of Compound C in myeloma cells. FIG. 9 shows CRBN immunoblot of extracts from DF15, DF15R shows lack of CRBN protein expression in DF15R cells. β-Tubulin immunoblot used as loading control. Cell proliferation assay of DF15 (sensitive), DF15R (resistant; CRBNnull) cells treated with a dose response of Compound C. Assays were done in triplicate and error bars represent s.d. Data for each cell line was normalized to treatment with vehicle (DMSO). FIG. 10 shows CRBN immunoblot of extracts from DF15, DF15R and DF15R cells re-expressing full length CRBN wild type (CRBNWT) or re-expressing RFP control. β-Tubulin immunoblot used as loading control. Cell proliferation assay of DF15 (sensitive), DF15R (resistant; CRBNnull), DF15R-hCRBNWT (human CRBN), DF15R-RFP cells treated with a dose response of Compound C. Data shows that re-expression of human CRBN in DF15R cells rescues Compound C anti-proliferative activity. Assays were done in triplicate and error bars represent s.d. Data for each cell line was normalized to treatment with vehicle (DMSO).

6.8.4. CRBN is Required for Anti-Proliferative Activity in Breast Cancer Cells

Breast cancer cells (MDA-MB-231) were treated with CRBN siRNA or a negative control. Compound C was added at a concentration between 0 to 100 μM, and CRBN levels were assessed at 48 hours post treatment. CRBN was significantly reduced in treated cells, as compared to a negative control receiving no siRNA (data not shown).

Compound C-mediated growth inhibition and pro-apoptotic activity were also assessed. As shown in FIG. 11, CRBN is required for both inhibition and pro-apoptotic activity of Compound C in the MDA-MB-213 breast cancer cells.

6.9 Structural Basis for Differentiated Responsiveness to Thalidomide-Class Drugs Defined by the Crystal Structure of a Lenalidomide:Human Cereblon: DDB1 Complex

The ubiquitin-proteasome pathway (UPP) is the principal mechanism by which proteins become marked for degradation contributing to intracellular protein homeostasis. Dysregulation of this key protein homeostatic mechanism is implicated in the etiology of diseases including cancer, neurological conditions and metabolic diseases (Petroski et al. BMC Biochem, 2008. 9Suppl1:S7. Drugs that modulate the ubiquitin-proteasome pathway therefore have the potential to impact a wide range of biological processes and diseases including cancer. Thalidomide (THAL) and related immunomodulatory agents, such as lenalidomide (LEN) and pomalidomide (POM), have shown anticancer effects in different indications by the direct inhibition of cancer cell proliferation, modulation of the tumor microenvironment, and immunomodulation or stimulation (Ramsay et al., Blood, 2012. 120(7):1412-21; Quach et al., Leukemia, 2010. 24(1):22-32; Ramsay et al., Blood, 2013. 121(14): p. 2704-14; Eve et al, Br J Haematol., 2012. 159(2):154-63).

Cereblon (CRBN), first identified as a genetic cause of inherited autosomal recessive mental retardation, is a component of a ubiquitin E3 cullin4-ring ligase (CRL4) complex, and is the direct target of THAL and other immunomodulatory agent drugs. CRL4 ubiquitin ligases are formed by a Cullin protein (CUL4), which acts as an assembly factor that provides a scaffold for assembly of a RING-box domain protein (RBX1) and the adaptor protein Damaged DNA Binding Protein 1 (DDB1) (Angers et al., Nature, 2006. 443(7111):590-3). RBX1 is the docking site for the activated E2 protein, and DDB1 recruits substrate specificity receptors or DCAFs (DDB1-cullin4-associated-factors) to form the substrate-presenting side of the CRL4 complex (Angers et al., Nature, 2006. 443(7111):590-3; He et al., Genes Dev, 2006. 20(21):2949-54; Higa et al. Nat Cell Biol, 2006. 8(11): p. 1277-83). Roughly 60 DCAFs have been identified. These DCAFs are characterized by the presence of a WD-repeat domain (Higa et al. Nat Cell Biol, 2006. 8(11):1277-83). Biochemical and genetic evidence has shown that CRBN is a DCAF for CRL4 (Angers et al., Nature, 2006. 443(7111):590-3, Ito et al., Science, 2010. 327(5971):1345-50), and that binding of immunomodulatory agent compounds to CRBN affects CRL4CRBN ubiquitin E3 ligase activity thus mediating the anti-proliferative effects on multiple myeloma (MM) cells and the immunomodulatory effects on T cells (Ito et al., Science, 2010. 327(5971):1345-50; Lopez-Girona et al., Leukemia, 2012. 26(11):2326-35; Zhu et al., Blood. 2011. 118(18):4771-9).

Recently, several groups have identified the transcription factors Ikaros and Aiolos as substrates of the CRL4CRBN-immunomodulatory agent drug complex, thus explaining many of the therapeutic effects of immunomodulatory agent compounds on immune and tumor cells. These reports describe that binding of immunomodulatory agent compounds to CRBN promotes recruitment of Ikaros or Aiolos to CRL4CRBN resulting in the increased ubiquitylation and proteasomal-dependent degradation of these transcription factors in both MM and T cells. In myeloma cells, targeted knockdown of Ikaros and Aiolos mimics the decrease of the myeloma survival factor, IRF4, as well as the decrease in cell viability observed with immunomodulatory agent treatment. In T cells, Ikaros and Aiolos are known repressors of interleukin-2 (IL-2) transcription, and knockdown of either protein produces an increase in IL-2 similar to immunomodulatory agent drug treatment (Gandhi et al., Br J Haematol.; Lu et al., Science; Kronke, et al., Science, 2014. 343(6168):301-5.). These findings demonstrated that immunomodulatory agent binding confers new functionality to the CRL4CRBN complexes, raising the possibility that an immunomodulatory agent conferred neo-morphic structure is involved.

One further feature of historical and developmental importance in the pharmacology of lenalidomide and related drugs is the species specificity which these compounds exhibit. For example, it has been shown that mice and rats are insensitive to the teratogenic effects of thalidomide and lenalidomidE (Newman et al., Reprod Toxicol, 1993. 7(4):359-90), while primates, including humans, are sensitive. Consistent with the species differences in pharmacology, we demonstrate that mouse splenocytes are resistant to the IL-2 inducing effects of pomalidomide and that in a mouse A20 cell line engineered to express human cereblon and human Aiolos, mouse Aiolos is not degraded in the presence of lenalidomide while human Aiolos is.

6.9.1. Summary

The Cul4:Rbx1:DDB1:Cereblon E3 ubiquitin ligase complex has been identified as the molecular target of a therapeutically important class of molecules known as immunomodulatory agent drugs or immunomodulatory Drugs. Immunomodulatory agent drugs directly bind Cereblon (CRBN) and in the process modulate the activity of the E3 ubiquitin ligase and the resulting stability of its client proteins. The recently described lenalidomide-mediated recruitment of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) to the E3 complex promoting enhanced ubiquitination and degradation provides insight into the molecular basis for therapeutic activity of immunomodulatory agent drugs in multiple myeloma and other B cell malignancies.

Herein we describe the crystal structure of human CRBN bound to DDB1 and the immunomodulatory agent drug lenalidomide. CRBN binds DDB1 in the same cleft utilized by other DDB1 and Cullin Associated Factors (DCAFs); however, the interactions are non-canonical and involve more extensive interactions with both the beta-propeller A and C domains. The immunomodulatory agent binding site is comprised of a tryptophan ringed hydrophobic pocket which binds the glutarimid moiety common to lenalidomide, thalidomide, and pomalidomide. This binding conformation orients lenalidomide's isoindolinone ring towards solvent with the functional consequence of altering the substrate recognition properties of the E3 ligase.

Using structure guided point mutations and lentiviral knock-in myeloma models, we show that key immunomodulatory agent drug binding site residues are critical for drug-mediated myeloma cell antiproliferative effects. Importantly, a species specific CRBN polymorphism in rodents proximal to the lenalidomide binding site provides explanation for the long appreciated species specific responsiveness in humans and primates compared with rodents.

6.9.2. Materials and Methods

6.9.2.1 Structural Determination

Cereblon immunomodulatory agent-binding domain was purified as follows: The gene encoding the thalidomide binding domain (TBD) of human CRBN (amino acids 319-427) or mouse CRBN (amino acids 322-430) was codon optimized and inserted into a pGEX6P-3 vector for expression as a GST-fusion protein in E. coli. BL21 (DE3) Star cells transformed with either plasmid were grown to OD 0.6 in TB media supplemented with 50 μM zinc acetate, and induced with 0.5 mM IPTG for 4 hours at 37 C. Cells were resuspended in lysis buffer containing 50 mM Tris pH 7, 150 mM NaCl, 10% glycerol, 2 mM TECP, 1 mM DTT, 100 U/mL benzonase (Novagen), 1× Protease Inhibitor Cocktail-EDTA free (SD Biosciences), 0.5 mg/mL lysozyme (Sigma), and sonicated for 30 s before ultracentrifuation for 30 min at 100,000×g. GST-fused CRBN was then bound to glutathione affinity resin, washed in 50 mM Tris pH 7, 150 mM NaCl, 10% glycerol, 2 mM TCEP, 1 mM DTT, and eluted in the same buffer with the addition of 40 mM reduced glutathione. The GST tag was removed by overnight cleavage at 4 C with PreScission Protease (1U/mg protein, GE Healthcare). CRBN TBD was further purified with ion-exchange chromatography by diluting the cleaved protein to 75 mM NaCl usign 50 mM Tris pH 7, 2 mM TCEP and 1 mM DTT, and binding to either a Mono S column (mouse TBD) or heparin column (human TBD). Protein was eluted using a gradient from 90 mM to 1M NaCl and pooled for size exclusion chromatography. Mouse CRBN TBD was purified by size exclusion over an S75 16/600 in 5 mM sodium acetate pH 6, 10 mM TECP, and 5 mM DTT. Human CRBN TBD was purified over an S75 16/600 in 20 mM MES pH 6, 200 mM NaCl, 10 mM TCEP and 1 mM DTT. Either the human or the mouse protein was concentrated to 17 mg/mL. Alternatively, residues of murine 321-429 fused to GST were expressed in E. coli. Cells were lysed by sonication and the soluble fraction purified using GST-trap, ion exchange and size-exclusion chromatography. Protein was concentration to 28 mg/ml in 50 mM acetate buffer, pH 6.0, 1 mM DTT, 10 mM TCEP. Crystals were obtained by sitting drop vapor diffusion by mixing the protein buffer 1:1 with and equilibrating against a mother liquor of crystallization buffer. For the mouse unbound TBD, the crystallization buffer contained 100 mM Sodium acetate pH 5, 600-800 mM Ammonium sulfate. Crystals were grown at 4 degrees centrigrade and cryoprotected by addition of 20% glycerol and frozen under liquid nitrogen. Human TBD crystallized in both 100 mM sodium cacodylate pH 6.5, 200 mM ammonium sulfate, and 30% PEG 8,000, and 100 mM sodium cacodylate pH 6.5, 200 mM lithium sulfate, 25% PEG 2000 MME at 4 degrees centrigrade. Crystals were cryoprotected by the addition of 20% ethylene glycol prior to freezing. Crystals of murine TBD in complex with Compound B were formed by sitting drop vapor diffusion. Compound B was added to the protein to a final concentration of 1 mM, and the protein droplet was mixed 1:1 with, and subsequently equilibrated against a reservoir solution of 100 mM MES pH 6.5, 10 mM zinc sulfate heptahydrate, 25% PEG MME 550 and incubated at 4 degrees centrigrade. Crystals were cryoprotected by addition of 20% glycerol and frozen under liquid nitrogen.

The structure of murine cereblon thal-binding domain was solved by single wavelength anomalous dispersion using intrinsically bound zinc ions. Briefly, 480 degrees of data were collected from a single crystal at 1.0A wavelength. Data were integrated and scaled using HKL2000 (Otwinowski et al., Methods in Enzymology, 1997. 276:307-326). Phasing and automated model building were performed with Crank in CCP4i, using the following subprograms: AFRO/CRUNCH2/BP3/SOLOMON/Buccaneer (Abrahams et al., Acta Crystallogr D Biol Crystallogr, 1996. 52(Pt 1): 30-42; de Graaff, R. A., et al., Acta Crystallogr D Biol Crystallogr, 2001. 57(Pt 12): 1857-62; Pannu et al., Acta Crystallogr D Biol Crystallogr, 2004. 60(Pt 1): 22-7; Pannu et al., Acta Crystallogr D Biol Crystallogr, 2011. 67(Pt 4): 331-7). Subsequent manual model building and refinement were performed using Coot and Refmac5, respectively (Murshudov et al., Acta Crystallogr D Biol Crystallogr, 2011. 67(Pt 4): 355-67; Emsley et al., Acta Crystallogr D Biol Crystallogr, 2010. 66(Pt 4): 486-501). Subsequent structures were solved by molecular replacement using Phaser (McCoy et al., J Appl Crystallogr, 2007. 40(Pt 4): 658-674).

Human CRBN (amino acids 40-442) fused to a N-terminal ZZ-6×His tag with a thrombin cleavage site and full length human DDB1 with or without a C-terminal strep-tag were co-expressed in SF9 insect cells using ESF921 medium supplemented with 50 μM zinc acetate. Cells were resuspended in 8 volumes Lysis Buffer (50 mM Tris pH 7.5, 500 mM NaCl, 10% Glycerol, 10 mM Imidazole, 1 mM TCEP) plus 1× protease inhibitor cocktail and 2,000 Units TurboNuclease for 1 hour at 4° C. The lysate was centrifuged at 105,000×g for 1 hour and the supernatant was loaded to 5 mL Ni-NTA, pre-equilibrated in lysis buffer. CRBN-DDB1 was eluted using a stepwise method with Elution Buffer (50 mM Tris pH 7.5, 500 mM NaCl, 10% Glycerol, 500 mM Imidazole, 1 mM TCEP). Peak fractions were pooled and the ZZ-6×His tag was cleaved by incubation with thrombin overnight at 4 C (1 mg thrombin/100 mg target protein, Enzyme Research). Protein was subsequently diluted to 200 mM NaCl. Diluted complex was immediately applied to a HiTrap™ ANX 5 mL column (GE Lifesciences). Sample was loaded under a Tris pH 7.5 environment and changed on-column to Bis-Tris pH 6.0. Protein was eluted using a linear gradient from 200 mM to 1M NaCl. CRBN-DDB1 complex protein was polish purified by S-400 gel filtration (GE Lifesciences). Complexed protein, as identified by SDS-PAGE, was pooled and setup in crystallization or stored at −80° C. in protein buffer (10 mM MES pH 6.0, 200 mM NaCl, 5 mM TCEP). CRBN-DDB1 at 30.2 mg/ml in storage buffer consisting of 10 mM MES pH6.0, 200 mM NaCl, 5 mM TCEP, or in an alternative buffer of 10 mM HEPES pH 7, 250 mM NaCl, 3 mM TCEP. CRBN-DDB1 was crystallized by sitting drop vapor diffusion. 1 mM lenalidomide was added to the mixture of CRBN-DDB1-Lenalidomide mixed 1:1 with, and subsequently equilibrated against, a reservoir solution containing 18% (w/v) PEG 10K (Hampton Research, Aliso Viejo, Calif.) and 100 mM HEPES pH 7.5 (Hampton Research, Aliso Viejo, Calif.). Initial crystallization conditions were identified by sparse matrix screening. Co-crystals appeared in seven days and reached dimensions of 0.10 mm×0.025 mm×0.025 mm by 21 days. Before data collection, crystals were cryoprotected in the reservoir solution supplemented with 20% Ethylene glycol and frozen in liquid nitrogen. The structure of human cereblon:DDB1 was solved by molecular replacement using Phaser (McCoy et al., J Appl Crystallogr, 2007. 40(Pt 4): 658-674), with DDB1 (PDB code 3EOC) and the murine cereblon TBD as search models. Subsequent manual model building and refinement were performed using Coot and Refmac5, respectively (Murshudov et al., Acta Crystallogr D Biol Crystallogr, 2011. 67(Pt 4): 355-67; Emsley et al., Acta Crystallogr D Biol Crystallogr, 2010. 66(Pt 4): 486-501) For the human CRBN-DDB1-Compound B structure, Compound B was added to the protein at 1 mM and was mixed 1:1 with buffer containing 200 mM sodium fluoride and 20% PEG 3350 and equilibrated against a mother liquor containing the same buffer at 20 C. Crystals were cryoprotected by the addition of 20% ethylene glycol.

6.9.2.2 Cell Lines

The DF15R cell line, previously shown to lack detectable CRBN protein, was grown and cultured as previously described (Lopez-Girona et al., Leukemia, 2012. 26(11):2326-35).

6.9.2.3 Wild-Type and Mutant CRBN Plasmids

Lentiviral expression vectors were produced in-house. Lentiviral particles were generated using HEK-293T cells and infection was done utilizing spinoculation methodology. Selection was performed 1 week after initial infection. DF15 and DF15R cells were transduce and a pool of puromycin-resistant cells selected and screened by Western blotting analysis with anti-CRBN antibody (Lopez-Girona et al., Leukemia, 2012. 26(11):2326-35). We confirmed the presence of the corresponding CRBN mutant versions by DNA genomic sequencing in all cell lines.

6.9.2.4 CRBN Short Hairpin RNA (shRNA) Constructs

Inducible shRNA constructs targeting CRBN or a control construct (Open Biosystems) were transduced using spinoculation methodology into the multiple myeloma cell lines H929 and U266. Stably transduced cells were selected with puromycin. Inducible shRNA expression (marked by RFP) was monitored by fluorescence microscopy and flow cytometry using 1 μg/mL doxycycline. CRBN protein expression was quantified by Western blotting. Cell proliferation and viability were assessed by 7AAD/flow cytometry assays.

6.9.2.5 Immunoblot and Immunohistochemistry

Western blotting was performed with antibodies to Aiolos (Santa Cruz) IRF4, c-Myc, p21, p27, and ppRb (Ser608). CRBN65 antibody was used for CRBN protein detection (Lopez-Girona et al., Leukemia, 2012. 26(11):2326-35). Cereblon immunohistochemistry (IHC) was performed on the Bond-Max® automated slide stainer (Leica Microsystems, Buffalo Grove, Ill.) using the Bond Polymer Refine® Detection system. Formalin fixed paraffin embedded (FFPE) cell pellets were sectioned at four micron thick and deparaffinized on the Bond-Max instrument. Antigen retrieval was performed with Epitope Retrieval® 2 (ER2, pH 9.0) for 20 min at 100° C. The slides were blocked for endogenous peroxidase activity with Peroxide Block for 5 minutes at room temperature. Sections were then incubated with the rabbit monoclonal antibody CRBN65 at a 1:4,000 dilution for 15 min at room temperature. Post-Primary and horseradish peroxidase (HRP) labeled Polymer were incubated at the instrument's default conditions. Antigen-antibody complex was then visualized with hydrogen peroxide substrate and diaminobenzidine tetrahydrochloride (DAB) chromogen. Slides were counterstained with hematoxylin.

6.9.2.6 Thalidomide Analog Bead Assay to Measure Compound Binding to Endogenous CRBN

Coupling of thalidomide analog to FG-magnetic nanoparticle beads (Tamagawa Seiko Co. Tokyo, Japan) was carried out as described (Ito et al., Science, 2010. 327(5971):1345-50), and cell extract binding assays to these beads were performed with minor modifications. DF15, DF15R or DF15R derived cell line extracts were prepared in NP 40 lysis buffer (0.5% NP40, 50 mM Tris HCl (pH 8.0), 150 mM NaCl, 0.5 mM DTT, 0.25 mM PMSF, 1× protease inhibitor mix (Roche, Indianapolis, Ind.) at approximately 2×108 cells per ml (20 mg protein/ml). Cell debris and nucleic acids were cleared by centrifugation (14,000 rpm 30 min 4° C.). In competition experiments 0.5 ml (3-5 mg protein) aliquots of the resulting extracts were preincubated (15 min room temp.) with 5 μl DMSO (control) or 5 μl compound at varying concentrations in DMSO. Thalidomide analog-coupled beads (0.3-0.5 mg) were added to protein extracts and samples rotated (2 hours, 4° C.). Beads were washed three times with 0.5 ml NP40 buffer, and then bound proteins were eluted with SDS-PAGE sample buffer. Samples were subjected to SDS-PAGE and immunoblot analysis, performed using anti-CRBN 65-76 (Lopez-Girona et al., Leukemia, 2012. 26(11):2326-35) (1:10,000 dilution) for all studies; other antisera dilutions were DDB1 (1:2,000 dilution) or β-actin (1:10,000 dilution). In thalidomide affinity bead competition assays, a LI-COR Odessey™ system was used to quantify CRBN band density and relative amounts of CRBN were determined by averaging at least three DMSO controls and expressing CRBN in each competition sample as percent inhibition of CRBN protein relative to the averaged controls as 100% binding.

6.9.3. Results

6.9.3.1 Crystal Structure of CRBN in Complex with DDB1 and Lenalidomide

The structure of CRBN reveals that CRBN is a DCAF that does not exhibit a WD-repeat architecture typical of the class. The CRBN structure (FIG. 12) reveals two distinct domains: an N-terminal Lon-like domain (LLD), and a C-terminal TBD. The structure reveals that the DDB1 and immunomodulatory agent binding sites occur on opposite sides of the cereblon surface. A human polymorphism linked to mental retardation has been found in CRBN resulting in premature truncation of CRBN at amino acid 419. The deleted region occurs within the immunomodulatory agent binding domain, with a short helical region and a β-strand removed (deleted region shown in red in FIG. 12). The deleted region occurs at the interface between the LLD and TBD, and truncation of these residues might be expected to deleteriously affect the domain structure and stability of CRBN.

The CRBN Lon-like domain (LLD) spans residues 76-318 and contains the DDB1 binding motif. Structural alignment with Bacillus subtilis Lon N-terminal domain yields an RMSD of 2.4 Angstroms over 165 aligned residues (FIG. 13) (Duman et al., J Mol Biol, 2010. 401(4): p. 653-70). However, as shown in FIG. 13, the DDB1 binding motif and the immunomodulatory agent binding site do not exhibit any homology with the examined Lon domains. When compared to B. subtilis Lon, the DDB1 binding motif appears to have been inserted into the Lon-like domain, and is composed of a series of helices between CRBN residues 188 and 248. CRBN binds between the beta propeller A (BPA) and the beta propeller C (BPC) domains of DDB1 in a similar location to other DCAFs (e.g. DDB2 or DCAF9), as well as to the viral DDB1 binding proteins Hbx and SV5V (Li et al., Nat Struct Mol Biol, 2010. 17(1): p. 105-11). However, although CRBN binds to DDB1 in the same region, the nature of the interaction with DDB1 exhibits differences compared to DDB2, SV5V or Hbx. Previously studied DCAFs position a helix-turn-helix motif in the DDB1 binding site which predominantly forms interactions with the BPC domain (FIG. 14, helices c and d) (Li et al., Nat Struct Mol Biol, 2010. 17(1): p. 105-11). CRBN interacts with DDB1 via a series of helices; however, these do not superpose with the DCAFs which have been structurally characterized (FIG. 14). In CRBN, residues 221-248 form helices which interact with the DDB1 BPC domain (helix a and b, FIG. 14). CRBN residues 191-197 also interact with DDB1 BPC in a proximal region to DDB2 (FIG. 13). However, as well as interacting with the BPC domain, CRBN also positions a helix composed of residues 198 to 209 to interact with the BPA domain of DDB1, the first example of such an interaction (helix e, FIG. 14). After the DDB1 binding motif, structural homology with the Lon domain is restored between residue 249 and 318 which form a 4-helix bundle, thus leading to the immunomodulatory agent binding domain, or thalidomide binding domain (TBD) at residues 319-428.

The TBD is located on the face of CRBN which is oriented away from the DDB1-binding site. The TBD is composed of a six-stranded antiparallel β-sheet core, with a structural zinc ion, coordinated by four cysteine residues, located ˜18 Å from the immunomodulatory agent binding site (FIG. 18). The immunomodulatory agent binding pocket itself is formed by three tryptophan residues, Trp380, Trp386, and Trp400, with a phenylalanine residue at the base (Phe402) (FIG. 18). These residues form a small hydrophobic pocket (tri-Trp pocket) in which the glutarimide portion of lenalidomide is accommodated. Within the tri-Trp pocket there are two hydrogen bonds between the glutarimide ring and the protein backbone at residues His378 and Trp380 (FIG. 13), and a further hydrogen bond with the sidechain of His378. The isoindolinone ring of lenalidomide is not enclosed within the hydrophobic pocket, and instead presents on the surface of the protein interacting with a beta-turn encompassing residues 351-353 (indicated by the symbol β in FIG. 13). The carbonyl oxygen of the isoindolinone ring is oriented towards the sidechain of His357; however, the distance is slightly too long for a hydrogen bond to form (4.1 Å). Similarly, the aniline amino group of lenalidomide is oriented towards Glu377, but at a distance too great for an interaction to be made (5.5 Å).

In determining whether CMA drug interaction with CRBN may serve to alter the specificity of the Cul4 ubiquitin ligase complex by recruitment of new partners or altering the substrate affinity of its client substrates, it is intriguing that the isoindolinone ring is exposed on the surface of the CRBN-immunomodulatory agent complex, indicating that this part of the immunomodulatory agent molecule would be available to form part of a ‘neomorphic’ interface in substrate recruitment. In this instance, the unused hydrophobic and polar bonding potential of the immunomodulatory agent and the adjacent protein surface could play a key role in altering/enhancing binding partner recruitment.

The TBD can be expressed and purified in isolation, and we have used this system to obtain crystal structures of the murine CRBN TBD in complex with thalidomide and pomalidomide. The TBD structure was initially solved by taking advantage of the predicted zinc binding site in a single wavelength anomalous dispersion experiment at a normal synchrotron wavelength of 1.0 Å. We noted that the electron density favors the S-enantiomer of thalidomide, which was crystallized as a racemic mixture. We subsequently confirmed that S-thalidomide binds CRBN more tightly than the R-enantiomer by competition for thalidomide immobilized beads (FIG. 21) consistent with previous results using the conformationally stable R- and S-methyl-pomalidomide analogs (Lopez-Girona et al., Leukemia. 26(11):2326-35). The core features of the immunomodulatory agent binding site which interact with the glutarimide ring are well conserved between the lenalidomide, thalidomide and pomalidomide structures, with the three tryptophans providing the key interactions to the glutarimide ring. The two hydrogen bonds to His378 and Trp380 are also conserved; however, the third hydrogen bond to the sidechain of His378 is not made. There is a striking difference between the lenalidomide structure and the others: the two beta-strands composed of residues 346-363 are absent in both the thalidomide and the pomalidomide structures (FIGS. 15, 16 and 17). There are four protein-drug pairs in the asymmetric unit for both the thalidomide and pomalidomide structures. In all proteins in the asymmetric unit in the pomalidomide structure the beta-strand region is completely disordered (FIG. 17). The same is true for one protein (chain A) in the thalidomide structure (FIG. 16); however, in chains B and D the beta-strands have adopted an alternative conformation where these residues bind the phthalimide ring of thalidomide from an adjacent molecule in the asymmetric unit (FIG. 20). This reciprocal arrangement forms a dimer in the crystal lattice, with Tyr355 stacking against the accessible surface of the immunomodulatory agent. There is no evidence of dimerization in the presence or absence of immunomodulatory agent (data not shown). The change in conformation provides a substantial change in the surface of CRBN in the immunomodulatory agent binding site vicinity, with the intriguing potential to influence binding partner recruitment. The extent to which different conformations are influenced by protein truncation or the lattice environment is unknown.

The alternative substitutions on the isoindolinone/phthalimide ring provide a second potential mechanism by which to selectively recruit binding partners to the Cul4:DDB1:CRBN E3 ligase complex. Lenalidomide and pomalidomide differ from thalidomide in possessing an NH₂ substitution on the isoindolinone/phthalimide ring. In the lenalidomide structure this NH₂ moiety is oriented towards Glu377, where in the pomalidomide structure this group appears to be able to orient into either direction as the electron density supports differing orientations in the different chains in the asymmetric unit (data not shown).

We further sought to confirm that the immunomodulatory agents binding pocket is present in the absence of ligand by determining the structure of apo TBD. This structure clearly shows that the pocket can exist in a similar conformation in the absence of ligand (Table 2)

TABLE 2 Crystallographic Statistics Protein: CRBN:DDB1: CRBN(TBD): CRBN(TBD): Ligand Lenalidomide Pomalidomide Thalidomide Data CLS CMCF-08ID ALS 8.2.1 APS SER-CAT collection 22ID site Wavelength 1.0 1.0 1.0 (Å) Resolution 50-3.0 (3.12-3.01)* 50-2.0 (2.11-2.00) 50-1.88 (1.95-1.88) Range (Å) Spacegroup P2₁2₁2₁ I23 I23 Cell 71.8 129.1 198.7 143.3 143.3 143.3 143.1 143.1 143.1 dimensions (Å) Angles (deg) 90 90 90 90 90 90 90 90 90 No. of 228444 83521 1750276 observations No. of unique 37313 25718 76864 observations Completeness  98.5 (85.8)*  92.3 (92.4) 99.9 (100.0) (%) I/σI 10.1 (2.6)  10.1 (5.4) 38.4 (6.6)  R_(merge) (%) 18.1 (72.3)  9.0 (24.5) 8.9 (59.9) Refinement statistics R_(work)/R_(free) 20.3/27.8 19.7/24.0 18.0/22.9 RMSD for 0.012 0.017 0.014 bond length (Å) RMSD for 1.25 1.723 1.676 bond angles (deg) *Figures in parentheses are for the outer resolution shell.

Table 3 below sets forth the atomic coordinates for CRBN:DDB1:Lenalidomide.

Table 4 below sets forth the atomic coordinates for CRBN(TBD):Pomalidomide.

Table 5 below sets forth the atomic coordinates for CRBN(TBD): Thalidomide.

Table 6 below sets forth the atomic coordinates for CRBN: DDB1: Compound B.

Table 7 below sets forth the atomic coordinates for CRBN (TBD): Compound B.

Table 8 below sets forth the atomic coordinates for unbound CRBN-CRBN (TBD) (Apo).

Atomic coordinates for CRBN:DDB1:Lenalidomide (Human protein) HEADER ---- XX-XXX-9- xxxx COMPND --- REMARK 3 REMARK 3 REFINEMENT. REMARK 3  PROGRAM : REFMAC 5.6.0117 REMARK 3  AUTHORS : REMARK 3 REMARK 3   REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3  DATA USED IN REFINEMENT. REMARK 3   RESOLUTION RANGE HIGH (ANGSTROMS) :  3.01 REMARK 3   RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 REMARK 3   DATA CUTOFF (SIGMA(F)) : NONE REMARK 3   COMPLETENESS FOR RANGE (%) : 99.40 REMARK 3   NUMBER OF REFLECTIONS : 35396 REMARK 3 REMARK 3  FIT TO DATA USED IN REFINEMENT. REMARK 3   CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3   FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3   R VALUE (WORKING + TEST SET) : 0.20710 REMARK 3   R VALUE (WORKING SET) : 0.20340 REMARK 3   FREE R VALUE : 0.27777 REMARK 3   FREE R VALUE TEST SET SIZE (%) : 5.0 REMARK 3   FREE R VALUE TEST SET COUNT : 1857 REMARK 3 REMARK 3  FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3   TOTAL NUMBER OF BINS USED : 20 REMARK 3   BIN RESOLUTION RANGE HIGH : 3.010 REMARK 3   BIN RESOLUTION RANGE LOW : 3.088 REMARK 3   REFLECTION IN BIN (WORKING SET) : 2223 REMARK 3   BIN COMPLETENESS (WORKING+TEST) (%) : 92.95 REMARK 3   BIN R VALUE (WORKING SET) : 0.275 REMARK 3   BIN FREE R VALUE SET COUNT : 111 REMARK 3   BIN FREE R VALUE : 0.352 REMARK 3 REMARK 3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3   ALL ATOMS : 11099 REMARK 3 REMARK 3  B VALUES. REMARK 3   FROM WILSON PLOT (A**2) : NULL REMARK 3   MEAN B VALUE (OVERALL, A**2) : 30.828 REMARK 3   OVERALL ANISOTROPIC B VALUE. REMARK 3    B11 (A**2) : −1.53 REMARK 3    B22 (A**2) :   1.71 REMARK 3    B33 (A**2) : −0.18 REMARK 3    B12 (A**2) :   0.00 REMARK 3    B13 (A**2) :   0.00 REMARK 3    B23 (A**2) :   0.00 REMARK 3 REMARK 3  ESTIMATED OVERALL COORDINATE ERROR. REMARK 3   ESU BASED ON R VALUE (A) : NULL REMARK 3   ESU BASED ON FREE R VALUE (A) :  0.477 REMARK 3   ESU BASED ON MAXIMUM LIKELIHOOD (A) :  0.336 REMARK 3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2) : 39.724 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3   CORRELATION COEFFICIENT FO-FC : 0.917 REMARK 3   CORRELATION COEFFICIENT FO-FC FREE : 0.868 REMARK 3 REMARK 3  RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3   BOND LENGTHS REFINED ATOMS (A): 11303 ; 0.012 ; 0.020 REMARK 3   BOND ANGLES REFINED ATOMS (DEGREES): 15349 ; 1.252 ; 1.961 REMARK 3   TORSION ANGLES, PERIOD 1 (DEGREES):  1409 ; 7.786 ; 5.000 REMARK 3   TORSION ANGLES, PERIOD 2 (DEGREES):  477 ; 40.149  ; 24.528  REMARK 3   TORSION ANGLES, PERIOD 3 (DEGREES):  1873 ; 20.308  ; 15.000  REMARK 3   TORSION ANGLES, PERIOD 4 (DEGREES):   51 ; 21.422  ; 15.000  REMARK 3   CHIRAL-CENTER RESTRAINTS (A**3):  1785 ; 0.086 ; 0.200 REMARK 3   GENERAL PLANES REFINED ATOMS (A):  8406 ; 0.008 ; 0.021 REMARK 3 REMARK 3  ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 REMARK 3  NCS RESTRAINTS STATISTICS REMARK 3   NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3  TWIN DETAILS REMARK 3   NUMBER OF TWIN DOMAIN : NULL REMARK 3 REMARK 3 REMARK 3   TLS DETAILS REMARK 3    NUMBER OF TLS GROUPS : 5 REMARK 3    ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3   TLS GROUP : 1 REMARK 3    NUMBER OF COMPONENTS GROUP : 1 REMARK 3    COMPONENTS C SSSEQI TO C SSSEQI REMARK 3    RESIDUE RANGE : A 393 A 708 REMARK 3    ORIGIN FOR THE GROUP (A) : −0.3068 15.1336 −7.6399 REMARK 3    T TENSOR REMARK 3     T11:   0.1628 T22:   0.2998 REMARK 3     T33:   0.0298 T12: −0.1471 REMARK 3     T13: −0.0098 T23:   0.0105 REMARK 3    L TENSOR REMARK 3     L11:   2.6533 L22:   2.7126 REMARK 3     L33:   2.2970 L12:   0.8261 REMARK 3     L13:   0.1789 L23: −0.4504 REMARK 3    S TENSOR REMARK 3     S11:   0.1379 S12: −0.2573 S13:   0.2315 REMARK 3     S21:   0.3045 S22: −0.1549 S23: −0.0219 REMARK 3     S31: −0.3251 S32:   0.4142 S33:   0.0170 REMARK 3 REMARK 3   TLS GROUP : 2 REMARK 3    NUMBER OF COMPONENTS GROUP : 1 REMARK 3    COMPONENTS C SSSEQI TO C SSSEQI REMARK 3    RESIDUE RANGE : A  1 A 392 REMARK 3    ORIGIN FOR THE GROUP (A): −13.1472 3.8365 −65.2475 REMARK 3    T TENSOR REMARK 3     T11:   0.1525 T22:   0.1346 REMARK 3     T33:   0.1167 T12: −0.0151 REMARK 3     T13:   0.0090 T23:   0.0399 REMARK 3    L TENSOR REMARK 3     L11:   0.4911 L22:   1.1590 REMARK 3     L33:   0.6814 L12: −0.1378 REMARK 3     L13: −0.0803 L23:   0.3506 REMARK 3    S TENSOR REMARK 3     S11:   0.0271 S12:   0.0480 S13: −0.0068 REMARK 3     S21: −0.1494 S22: −0.0207 S23: −0.0650 REMARK 3     S31:   0.0348 S32: −0.0012 S33: −0.0065 REMARK 3 REMARK 3   TLS GROUP : 3 REMARK 3    NUMBER OF COMPONENTS GROUP : 1 REMARK 3    COMPONENTS C SSSEQI TO C SSSEQI REMARK 3    RESIDUE RANGE : A 709 A 1200 REMARK 3    ORIGIN FOR THE GROUP (A): −21.4420 29.8478 −47.2567 REMARK 3    T TENSOR REMARK 3     T11:   0.1311 T22:   0.1037 REMARK 3     T33:   0.1785 T12: −0.0149 REMARK 3     T13:   0.0266 T23:   0.0153 REMARK 3    L TENSOR REMARK 3     L11:   0.8961 L22:   0.4909 REMARK 3     L33:   0.5067 L12: −0.2898 REMARK 3     L13: −0.1289 L23: −0.0031 REMARK 3    S TENSOR REMARK 3     S11: −0.0251 S12: −0.0059 S13:   0.0840 REMARK 3     S21:   0.0400 S22:   0.0368 S23:   0.0082 REMARK 3     S31: −0.0496 S32: −0.0305 S33: −0.0117 REMARK 3 REMARK 3   TLS GROUP : 4 REMARK 3    NUMBER OF COMPONENTS GROUP : 1 REMARK 3    COMPONENTS C SSSEQI TO C SSSEQI REMARK 3    RESIDUE RANGE : C 187 C 256 REMARK 3    ORIGIN FOR THE GROUP (A): −31.3124 19.6121 −66.7413 REMARK 3    T TENSOR REMARK 3     T11:   0.2983 T22:   0.1909 REMARK 3     T33:   0.1527 T12:   0.0117 REMARK 3     T13: −0.0659 T23:   0.0171 REMARK 3    L TENSOR REMARK 3     L11:   0.3674 L22:   3.0198 REMARK 3     L33:   0.7357 L12: −0.5710 REMARK 3     L13: −0.2040 L23: −0.2416 REMARK 3    S TENSOR REMARK 3     S11:   0.1361 S12:   0.0628 S13: −0.0342 REMARK 3     S21: −0.0897 S22: −0.0133 S23:   0.1583 REMARK 3     S31: 0.2257 S32: −0.0128 S33: −0.1229 REMARK 3 REMARK 3   TLS GROUP : 5 REMARK 3    NUMBER OF COMPONENTS GROUP : 2 REMARK 3    COMPONENTS C SSSEQI TO C SSSEQI REMARK 3    RESIDUE RANGE : C  1 C 186 REMARK 3    RESIDUE RANGE : C 257 C 500 REMARK 3    ORIGIN FOR THE GROUP (A): −36.9305 47.0483 −87.0978 REMARK 3    T TENSOR REMARK 3     T11:   0.2231 T22:   0.1289 REMARK 3     T33:   0.1194 T12:   0.0228 REMARK 3     T13: −0.0118 T23:   0.0144 REMARK 3    L TENSOR REMARK 3     L11:   1.1260 L22:   0.9557 REMARK 3     L33:   1.7495 L12: −0.4292 REMARK 3     L13:   0.7316 L23: −0.9160 REMARK 3    S TENSOR REMARK 3     S11: −0.0115 S12: −0.0943 S13:   0.0603 REMARK 3     S21:   0.0310 S22: −0.1114 S23: −0.0638 REMARK 3     S31: −0.1272 S32: −0.0142 S33:   0.1229 REMARK 3 REMARK 3 REMARK 3  BULK SOLVENT MODELLING. REMARK 3   METHOD USED : MASK REMARK 3   PARAMETERS FOR MASK CALCULATION REMARK 3   VDW PROBE RADIUS : 1.20 REMARK 3   ION PROBE RADIUS : 0.80 REMARK 3   SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3  OTHER REFINEMENT REMARKS: REMARK 3  HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT REMARK 3  U VALUES : RESIDUAL ONLY REMARK 3 LINKR       ALA A  46       LEU A  49       gap LINKR GLN A  93 SER A  97 gap LINKR GLN A  209 ASN A  211 gap LINKR LYS A  287 THR A  296 gap LINKR ASN A  337 GLU A  342 gap LINKR GLU A  368 GLN A  372 gap LINKR PRO A  417 GLU A  420 gap LINKR GLU A  535 VAL A  538 gap LINKR LEU A  546 GLY A  551 gap LINKR LEU A  576 HIS A  578 gap LINKR ASP A  625 LYS A  627 gap LINKR SER A  643 SER A  645 gap LINKR ASP A  744 THR A  749 gap LINKR SER A  767 GLU A  784 gap LINKR ASP A  980 GLU A  987 gap LINKR VAL A 1013 THR A 1024 gap LINKR THR A 1078 LYS A 1081 gap LINKR GLY A 1117 ASP A 1121 gap LINKR SER C  126 GLU C  132 gap LINKR ARG C  172 GLY C  176 gap LINKR VAL C  213 TYR C  221 gap LINKR ASP C  265 SER C  272 gap CRYST1 71.862 129.117 198.677 90.00 90.00 90.00 P 21 21 21 SCALE1   0.013916   0.000000   0.000000   0.00000 SCALE2   0.000000   0.007745   0.000000   0.00000 SCALE3   0.000000   0.000000   0.005033   0.00000 ATOM 1 N SER A 2 −7.923 44.191 −51.658 1.00 21.42 N ATOM 2 CA SER A 2 −8.131 42.928 −50.873 1.00 22.29 C ATOM 3 CB SER A 2 −9.616 42.524 −50.829 1.00 23.04 C ATOM 4 OG SER A 2 −9.849 41.431 −49.937 1.00 22.96 O ATOM 5 C SER A 2 −7.266 41.758 −51.369 1.00 21.69 C ATOM 6 O SER A 2 −7.189 41.478 −52.568 1.00 22.35 O ATOM 7 N TYR A 3 −6.655 41.068 −50.406 1.00 20.49 N ATOM 8 CA TYR A 3 −5.609 40.085 −50.637 1.00 18.61 C ATOM 9 CB TYR A 3 −4.275 40.712 −50.280 1.00 18.10 C ATOM 10 CG TYR A 3 −4.027 42.055 −50.906 1.00 18.01 C ATOM 11 CD1 TYR A 3 −3.470 42.150 −52.184 1.00 17.99 C ATOM 12 CE1 TYR A 3 −3.214 43.380 −52.767 1.00 17.92 C ATOM 13 CZ TYR A 3 −3.514 44.537 −52.072 1.00 17.79 C ATOM 14 OH TYR A 3 −3.261 45.734 −52.674 1.00 17.76 O ATOM 15 CE2 TYR A 3 −4.065 44.480 −50.797 1.00 17.83 C ATOM 16 CD2 TYR A 3 −4.321 43.239 −50.221 1.00 17.87 C ATOM 17 C TYR A 3 −5.839 38.900 −49.707 1.00 17.88 C ATOM 18 O TYR A 3 −5.794 39.056 −48.487 1.00 18.43 O ATOM 19 N ASN A 4 −6.071 37.719 −50.263 1.00 16.80 N ATOM 20 CA ASN A 4 −6.498 36.592 −49.443 1.00 16.25 C ATOM 21 CB ASN A 4 −7.962 36.234 −49.742 1.00 16.86 C ATOM 22 CG ASN A 4 −8.860 37.457 −49.820 1.00 17.49 C ATOM 23 OD1 ASN A 4 −9.601 37.758 −48.885 1.00 17.63 O ATOM 24 ND2 ASN A 4 −8.782 38.185 −50.937 1.00 18.31 N ATOM 25 C ASN A 4 −5.607 35.356 −49.542 1.00 15.38 C ATOM 26 O ASN A 4 −4.938 35.137 −50.559 1.00 15.70 O ATOM 27 N TYR A 5 −5.628 34.551 −48.483 1.00 13.98 N ATOM 28 CA TYR A 5 −4.844 33.334 −48.371 1.00 13.09 C ATOM 29 CB TYR A 5 −4.060 33.422 −47.057 1.00 12.98 C ATOM 30 CG TYR A 5 −3.119 32.283 −46.708 1.00 12.85 C ATOM 31 CD1 TYR A 5 −1.776 32.309 −47.089 1.00 12.66 C ATOM 32 CE1 TYR A 5 −0.905 31.276 −46.739 1.00 12.60 C ATOM 33 CZ TYR A 5 −1.373 30.211 −45.981 1.00 12.76 C ATOM 34 OH TYR A 5 −0.544 29.165 −45.629 1.00 12.48 O ATOM 35 CE2 TYR A 5 −2.699 30.180 −45.570 1.00 12.91 C ATOM 36 CD2 TYR A 5 −3.555 31.216 −45.920 1.00 12.83 C ATOM 37 C TYR A 5 −5.817 32.142 −48.389 1.00 12.75 C ATOM 38 O TYR A 5 −6.718 32.060 −47.559 1.00 12.62 O ATOM 39 N VAL A 6 −5.675 31.245 −49.364 1.00 12.53 N ATOM 40 CA VAL A 6 −6.528 30.041 −49.427 1.00 12.16 C ATOM 41 CB VAL A 6 −7.111 29.740 −50.827 1.00 12.01 C ATOM 42 CG1 VAL A 6 −8.440 29.031 −50.691 1.00 11.90 C ATOM 43 CG2 VAL A 6 −7.288 30.990 −51.653 1.00 12.31 C ATOM 44 C VAL A 6 −5.702 28.833 −49.073 1.00 12.07 C ATOM 45 O VAL A 6 −4.670 28.568 −49.694 1.00 12.04 O ATOM 46 N VAL A 7 −6.173 28.079 −48.093 1.00 12.02 N ATOM 47 CA VAL A 7 −5.498 26.863 −47.702 1.00 12.08 C ATOM 48 CB VAL A 7 −4.578 27.110 −46.494 1.00 12.20 C ATOM 49 CG1 VAL A 7 −5.380 27.211 −45.197 1.00 12.19 C ATOM 50 CG2 VAL A 7 −3.503 26.036 −46.419 1.00 12.40 C ATOM 51 C VAL A 7 −6.512 25.751 −47.424 1.00 12.19 C ATOM 52 O VAL A 7 −7.632 26.022 −46.987 1.00 12.49 O ATOM 53 N THR A 8 −6.115 24.513 −47.704 1.00 11.94 N ATOM 54 CA THR A 8 −6.921 23.338 −47.435 1.00 11.84 C ATOM 55 CB THR A 8 −6.411 22.153 −48.265 1.00 12.28 C ATOM 56 OG1 THR A 8 −6.498 22.463 −49.660 1.00 12.25 O ATOM 57 CG2 THR A 8 −7.205 20.874 −47.954 1.00 12.37 C ATOM 58 C THR A 8 −6.830 22.923 −45.970 1.00 11.59 C ATOM 59 O THR A 8 −5.750 22.794 −45.424 1.00 11.59 O ATOM 60 N ALA A 9 −7.972 22.701 −45.341 1.00 11.44 N ATOM 61 CA ALA A 9 −7.986 22.193 −43.978 1.00 11.07 C ATOM 62 CB ALA A 9 −8.969 22.975 −43.138 1.00 11.25 C ATOM 63 C ALA A 9 −8.325 20.707 −43.946 1.00 10.83 C ATOM 64 O ALA A 9 −7.970 20.018 −43.003 1.00 10.79 O ATOM 65 N GLN A 10 −9.046 20.236 −44.963 1.00 10.58 N ATOM 66 CA GLN A 10 −9.366 18.824 −45.128 1.00 10.39 C ATOM 67 CB GLN A 10 −10.749 18.509 −44.551 1.00 10.35 C ATOM 68 CG GLN A 10 −11.327 17.163 −44.976 1.00 10.22 C ATOM 69 CD GLN A 10 −10.452 16.009 −44.547 1.00 10.19 C ATOM 70 OE1 GLN A 10 −10.178 15.849 −43.359 1.00 10.42 O ATOM 71 NE2 GLN A 10 −9.994 15.203 −45.508 1.00 9.87 N ATOM 72 C GLN A 10 −9.337 18.504 −46.615 1.00 10.53 C ATOM 73 O GLN A 10 −10.120 19.056 −47.385 1.00 10.94 O ATOM 74 N LYS A 11 −8.430 17.622 −47.022 1.00 10.37 N ATOM 75 CA LYS A 11 −8.288 17.259 −48.424 1.00 10.13 C ATOM 76 CB LYS A 11 −7.092 16.342 −48.611 1.00 10.25 C ATOM 77 CG LYS A 11 −5.742 16.959 −48.350 1.00 10.41 C ATOM 78 CD LYS A 11 −4.705 15.953 −48.785 1.00 10.73 C ATOM 79 CE LYS A 11 −3.386 16.161 −48.090 1.00 11.15 C ATOM 80 NZ LYS A 11 −2.882 14.810 −47.710 1.00 11.49 N ATOM 81 C LYS A 11 −9.533 16.529 −48.888 1.00 9.93 C ATOM 82 O LYS A 11 −10.219 15.929 −48.083 1.00 9.94 O ATOM 83 N PRO A 12 −9.809 16.553 −50.194 1.00 9.83 N ATOM 84 CA PRO A 12 −11.014 15.897 −50.738 1.00 9.94 C ATOM 85 CB PRO A 12 −10.818 15.986 −52.256 1.00 10.02 C ATOM 86 CG PRO A 12 −9.763 17.026 −52.460 1.00 10.06 C ATOM 87 CD PRO A 12 −8.900 17.031 −51.246 1.00 9.78 C ATOM 88 C PRO A 12 −11.095 14.440 −50.332 1.00 9.90 C ATOM 89 O PRO A 12 −10.087 13.739 −50.400 1.00 9.98 O ATOM 90 N THR A 13 −12.271 13.985 −49.903 1.00 10.05 N ATOM 91 CA THR A 13 −12.422 12.584 −49.438 1.00 10.17 C ATOM 92 CB THR A 13 −13.153 12.464 −48.087 1.00 9.80 C ATOM 93 OG1 THR A 13 −14.470 13.013 −48.207 1.00 9.74 O ATOM 94 CG2 THR A 13 −12.403 13.188 −47.005 1.00 9.47 C ATOM 95 C THR A 13 −13.124 11.688 −50.452 1.00 10.50 C ATOM 96 O THR A 13 −12.867 10.478 −50.486 1.00 10.93 O ATOM 97 N ALA A 14 −14.002 12.271 −51.272 1.00 10.59 N ATOM 98 CA ALA A 14 −14.754 11.506 −52.276 1.00 10.84 C ATOM 99 CB ALA A 14 −15.799 12.385 −52.914 1.00 10.95 C ATOM 100 C ALA A 14 −13.875 10.845 −53.355 1.00 10.99 C ATOM 101 O ALA A 14 −12.929 11.459 −53.837 1.00 11.15 O ATOM 102 N VAL A 15 −14.202 9.607 −53.734 1.00 11.13 N ATOM 103 CA VAL A 15 −13.449 8.870 −54.766 1.00 11.38 C ATOM 104 CB VAL A 15 −13.386 7.360 −54.447 1.00 11.25 C ATOM 105 CG1 VAL A 15 −12.963 6.561 −55.675 1.00 11.41 C ATOM 106 CG2 VAL A 15 −12.418 7.111 −53.303 1.00 11.07 C ATOM 107 C VAL A 15 −13.947 9.092 −56.215 1.00 11.67 C ATOM 108 O VAL A 15 −15.065 8.742 −56.538 1.00 12.02 O ATOM 109 N ASN A 16 −13.092 9.654 −57.072 0.50 11.92 N ATOM 110 CA ASN A 16 −13.407 9.906 −58.480 0.50 12.12 C ATOM 111 CB ASN A 16 −12.411 10.891 −59.054 0.50 12.15 C ATOM 112 CG ASN A 16 −12.697 12.292 −58.644 0.50 12.38 C ATOM 113 OD1 ASN A 16 −12.750 12.611 −57.453 0.50 12.39 O ATOM 114 ND2 ASN A 16 −12.892 13.156 −59.632 0.50 12.72 N ATOM 115 C ASN A 16 −13.326 8.673 −59.337 0.50 12.42 C ATOM 116 O ASN A 16 −14.118 8.480 −60.250 0.50 12.08 O ATOM 117 N GLY A 17 −12.311 7.870 −59.056 1.00 13.20 N ATOM 118 CA GLY A 17 −11.928 6.736 −59.890 1.00 14.55 C ATOM 119 C GLY A 17 −11.012 5.806 −59.122 1.00 15.30 C ATOM 120 O GLY A 17 −10.434 6.209 −58.115 1.00 15.79 O ATOM 121 N CYS A 18 −10.882 4.566 −59.585 1.00 15.81 N ATOM 122 CA CYS A 18 −10.156 3.552 −58.840 1.00 17.16 C ATOM 123 CB CYS A 18 −11.029 2.994 −57.700 1.00 17.76 C ATOM 124 SG CYS A 18 −12.709 2.452 −58.177 1.00 20.76 S ATOM 125 C CYS A 18 −9.681 2.444 −59.773 1.00 18.24 C ATOM 126 O CYS A 18 −10.489 1.730 −60.349 1.00 20.21 O ATOM 127 N VAL A 19 −8.367 2.300 −59.926 1.00 18.29 N ATOM 128 CA VAL A 19 −7.780 1.333 −60.878 1.00 17.71 C ATOM 129 CB VAL A 19 −7.087 2.100 −62.049 1.00 17.28 C ATOM 130 CG1 VAL A 19 −5.701 2.574 −61.650 1.00 16.84 C ATOM 131 CG2 VAL A 19 −7.028 1.261 −63.320 1.00 17.29 C ATOM 132 C VAL A 19 −6.814 0.322 −60.187 1.00 17.49 C ATOM 133 O VAL A 19 −6.242 0.608 −59.127 1.00 17.47 O ATOM 134 N THR A 20 −6.647 −0.859 −60.770 1.00 17.31 N ATOM 135 CA THR A 20 −5.632 −1.804 −60.276 1.00 17.57 C ATOM 136 CB THR A 20 −6.232 −3.101 −59.712 1.00 17.48 C ATOM 137 OG1 THR A 20 −7.084 −3.694 −60.694 1.00 17.58 O ATOM 138 CG2 THR A 20 −7.019 −2.828 −58.442 1.00 17.55 C ATOM 139 C THR A 20 −4.668 −2.191 −61.374 1.00 17.89 C ATOM 140 O THR A 20 −4.873 −1.847 −62.537 1.00 18.11 O ATOM 141 N GLY A 21 −3.623 −2.918 −61.001 1.00 18.04 N ATOM 142 CA GLY A 21 −2.567 −3.277 −61.933 1.00 18.71 C ATOM 143 C GLY A 21 −1.241 −3.263 −61.227 1.00 19.10 C ATOM 144 O GLY A 21 −1.200 −3.239 −59.996 1.00 19.56 O ATOM 145 N HIS A 22 −0.152 −3.269 −61.990 1.00 19.40 N ATOM 146 CA HIS A 22 1.170 −3.424 −61.381 1.00 20.26 C ATOM 147 CB HIS A 22 1.823 −4.717 −61.846 1.00 21.59 C ATOM 148 CG HIS A 22 0.972 −5.933 −61.584 1.00 23.17 C ATOM 149 ND1 HIS A 22 −0.212 −6.134 −62.203 1.00 24.33 N ATOM 150 CE1 HIS A 22 −0.768 −7.274 −61.751 1.00 24.58 C ATOM 151 NE2 HIS A 22 0.063 −7.806 −60.837 1.00 24.54 N ATOM 152 CD2 HIS A 22 1.144 −7.002 −60.709 1.00 23.76 C ATOM 153 C HIS A 22 2.037 −2.227 −61.591 1.00 19.84 C ATOM 154 O HIS A 22 2.707 −2.086 −62.621 1.00 20.42 O ATOM 155 N PHE A 23 2.033 −1.353 −60.590 1.00 18.33 N ATOM 156 CA PHE A 23 2.565 −0.020 −60.735 1.00 17.77 C ATOM 157 CB PHE A 23 1.480 1.004 −60.404 1.00 17.35 C ATOM 158 CG PHE A 23 1.892 2.426 −60.621 1.00 16.71 C ATOM 159 CD1 PHE A 23 2.126 2.905 −61.894 1.00 16.37 C ATOM 160 CE1 PHE A 23 2.509 4.216 −62.090 1.00 16.61 C ATOM 161 CZ PHE A 23 2.643 5.068 −61.012 1.00 16.74 C ATOM 162 CE2 PHE A 23 2.401 4.605 −59.735 1.00 16.88 C ATOM 163 CD2 PHE A 23 2.024 3.289 −59.546 1.00 16.73 C ATOM 164 C PHE A 23 3.800 0.213 −59.888 1.00 17.99 C ATOM 165 O PHE A 23 4.784 0.761 −60.381 1.00 18.85 O ATOM 166 N THR A 24 3.751 −0.189 −58.622 1.00 18.14 N ATOM 167 CA THR A 24 4.893 −0.021 −57.719 1.00 18.89 C ATOM 168 CB THR A 24 4.486 −0.155 −56.233 1.00 18.69 C ATOM 169 OG1 THR A 24 3.705 −1.340 −56.046 1.00 18.28 O ATOM 170 CG2 THR A 24 3.674 1.035 −55.800 1.00 18.88 C ATOM 171 C THR A 24 6.043 −0.993 −58.023 1.00 19.74 C ATOM 172 O THR A 24 7.164 −0.787 −57.566 1.00 20.39 O ATOM 173 N SER A 25 5.749 −2.025 −58.822 1.00 20.41 N ATOM 174 CA SER A 25 6.622 −3.185 −59.067 1.00 20.32 C ATOM 175 CB SER A 25 7.111 −3.769 −57.725 1.00 20.28 C ATOM 176 OG SER A 25 7.028 −5.184 −57.675 1.00 20.57 O ATOM 177 C SER A 25 5.806 −4.218 −59.873 1.00 20.44 C ATOM 178 O SER A 25 4.571 −4.192 −59.830 1.00 20.80 O ATOM 179 N ALA A 26 6.470 −5.108 −60.617 1.00 20.07 N ATOM 180 CA ALA A 26 5.746 −6.166 −61.356 1.00 20.11 C ATOM 181 CB ALA A 26 6.639 −6.840 −62.380 1.00 19.97 C ATOM 182 C ALA A 26 5.141 −7.207 −60.421 1.00 20.30 C ATOM 183 O ALA A 26 4.154 −7.860 −60.759 1.00 20.64 O ATOM 184 N GLU A 27 5.739 −7.351 −59.244 1.00 20.61 N ATOM 185 CA GLU A 27 5.282 −8.313 −58.253 1.00 20.91 C ATOM 186 CB GLU A 27 6.433 −8.709 −57.316 1.00 20.86 C ATOM 187 C GLU A 27 4.070 −7.793 −57.464 1.00 20.66 C ATOM 188 O GLU A 27 3.112 −8.527 −57.248 1.00 20.36 O ATOM 189 N ASP A 28 4.110 −6.527 −57.050 1.00 20.59 N ATOM 190 CA ASP A 28 3.005 −5.933 −56.290 1.00 20.28 C ATOM 191 CB ASP A 28 3.362 −4.503 −55.851 1.00 20.79 C ATOM 192 CG ASP A 28 4.696 −4.421 −55.103 1.00 21.97 C ATOM 193 OD1 ASP A 28 5.139 −5.467 −54.572 1.00 21.99 O ATOM 194 OD2 ASP A 28 5.299 −3.307 −55.036 1.00 22.11 O ATOM 195 C ASP A 28 1.717 −5.902 −57.120 1.00 19.66 C ATOM 196 O ASP A 28 1.763 −5.825 −58.345 1.00 19.97 O ATOM 197 N LEU A 29 0.572 −5.970 −56.452 1.00 18.76 N ATOM 198 CA LEU A 29 −0.690 −5.534 −57.057 1.00 17.92 C ATOM 199 CB LEU A 29 −1.778 −6.607 −56.923 1.00 18.23 C ATOM 200 CG LEU A 29 −3.231 −6.212 −57.243 1.00 18.16 C ATOM 201 CD1 LEU A 29 −3.535 −6.226 −58.734 1.00 17.53 C ATOM 202 CD2 LEU A 29 −4.171 −7.137 −56.489 1.00 18.27 C ATOM 203 C LEU A 29 −1.126 −4.249 −56.367 1.00 17.31 C ATOM 204 O LEU A 29 −1.214 −4.181 −55.132 1.00 17.65 O ATOM 205 N ASN A 30 −1.387 −3.221 −57.150 1.00 16.28 N ATOM 206 CA ASN A 30 −1.701 −1.944 −56.557 1.00 15.87 C ATOM 207 CB ASN A 30 −0.800 −0.864 −57.124 1.00 15.82 C ATOM 208 CG ASN A 30 0.643 −1.116 −56.821 1.00 15.96 C ATOM 209 OD1 ASN A 30 1.038 −1.174 −55.665 1.00 16.17 O ATOM 210 ND2 ASN A 30 1.437 −1.300 −57.855 1.00 16.26 N ATOM 211 C ASN A 30 −3.135 −1.552 −56.745 1.00 15.62 C ATOM 212 O ASN A 30 −3.783 −1.945 −57.710 1.00 16.26 O ATOM 213 N LEU A 31 −3.636 −0.772 −55.81 1.00 14.98 N ATOM 214 CA LEU A 31 −4.886 −0.109 −56.021 1.00 14.75 C ATOM 215 CB LEU A 31 −5.848 −0.414 −54.869 1.00 14.48 C ATOM 216 CG LEU A 31 −7.126 0.412 −54.726 1.00 14.07 C ATOM 217 CD1 LEU A 31 −7.984 0.348 −55.983 1.00 13.99 C ATOM 218 CD2 LEU A 31 −7.888 −0.072 −53.510 1.00 13.77 C ATOM 219 C LEU A 31 −4.556 1.370 −56.113 1.00 14.66 C ATOM 220 O LEU A 31 −3.905 1.912 −55.220 1.00 14.56 O ATOM 221 N LEU A 32 −4.959 1.999 −57.220 1.00 14.48 N ATOM 222 CA LEU A 32 −4.801 3.443 −57.397 1.00 14.27 C ATOM 223 CB LEU A 32 −4.130 3.769 −58.727 1.00 14.26 C ATOM 224 CG LEU A 32 −2.604 3.758 −58.730 1.00 14.43 C ATOM 225 CD1 LEU A 32 −2.052 2.351 −58.558 1.00 14.50 C ATOM 226 CD2 LEU A 32 −2.104 4.339 −60.032 1.00 14.66 C ATOM 227 C LEU A 32 −6.147 4.131 −57.308 1.00 13.95 C ATOM 228 O LEU A 32 −7.060 3.785 −58.047 1.00 13.86 O ATOM 229 N ILE A 33 −6.247 5.104 −56.399 1.00 13.61 N ATOM 230 CA ILE A 33 −7.499 5.793 −56.086 1.00 13.36 C ATOM 231 CB ILE A 33 −7.874 5.579 −54.609 1.00 13.17 C ATOM 232 CG1 ILE A 33 −7.966 4.100 −54.279 1.00 13.23 C ATOM 233 CD1 ILE A 33 −8.277 3.831 −52.824 1.00 13.39 C ATOM 234 CG2 ILE A 33 −9.192 6.257 −54.279 1.00 13.29 C ATOM 235 C ILE A 33 −7.376 7.304 −56.320 1.00 13.55 C ATOM 236 O ILE A 33 −6.506 7.965 −55.740 1.00 13.95 O ATOM 237 N ALA A 34 −8.250 7.862 −57.141 1.00 13.28 N ATOM 238 CA ALA A 34 −8.242 9.303 −57.338 1.00 13.46 C ATOM 239 CB ALA A 34 −8.482 9.640 −58.798 1.00 13.49 C ATOM 240 C ALA A 34 −9.256 10.032 −56.448 1.00 13.71 C ATOM 241 O ALA A 34 −10.446 9.726 −56.451 1.00 13.94 O ATOM 242 N LYS A 35 −8.772 11.000 −55.689 1.00 13.73 N ATOM 243 CA LYS A 35 −9.634 11.907 −54.974 1.00 13.74 C ATOM 244 CB LYS A 35 −9.301 11.870 −53.489 1.00 13.64 C ATOM 245 CG LYS A 35 −9.925 10.690 −52.773 1.00 13.75 C ATOM 246 CD LYS A 35 −8.974 10.076 −51.777 1.00 13.86 C ATOM 247 CE LYS A 35 −9.725 9.324 −50.698 1.00 14.04 C ATOM 248 NZ LYS A 35 −9.243 9.724 −49.347 1.00 14.20 N ATOM 249 C LYS A 35 −9.436 13.305 −55.549 1.00 14.30 C ATOM 250 O LYS A 35 −8.653 14.102 −55.011 1.00 14.27 O ATOM 251 N ASN A 36 −10.141 13.582 −56.658 1.00 14.67 N ATOM 252 CA ASN A 36 −10.099 14.885 −57.368 1.00 14.86 C ATOM 253 CB ASN A 36 −10.785 15.992 −56.550 1.00 14.52 C ATOM 254 CG ASN A 36 −10.960 17.286 −57.325 1.00 14.26 C ATOM 255 OD1 ASN A 36 −11.093 17.288 −58.540 1.00 14.27 O ATOM 256 ND2 ASN A 36 −10.999 18.393 −56.610 1.00 14.18 N ATOM 257 C ASN A 36 −8.694 15.311 −57.792 1.00 15.53 C ATOM 258 O ASN A 36 −8.268 15.027 −58.913 1.00 15.76 O ATOM 259 N THR A 37 −7.982 15.997 −56.901 1.00 16.35 N ATOM 260 CA THR A 37 −6.615 16.454 −57.187 1.00 17.25 C ATOM 261 CB THR A 37 −6.415 17.944 −56.816 1.00 16.76 C ATOM 262 OG1 THR A 37 −6.870 18.166 −55.477 1.00 17.00 O ATOM 263 CG2 THR A 37 −7.183 18.833 −57.735 1.00 15.73 C ATOM 264 C THR A 37 −5.554 15.610 −56.464 1.00 18.24 C ATOM 265 O THR A 37 −4.379 15.983 −56.417 1.00 18.84 O ATOM 266 N ARG A 38 −5.966 14.476 −55.903 1.00 19.00 N ATOM 267 CA ARG A 38 −5.054 13.627 −55.132 1.00 19.34 C ATOM 268 CB ARG A 38 −5.478 13.595 −53.668 1.00 20.22 C ATOM 269 CG ARG A 38 −5.476 14.947 −52.989 1.00 21.38 C ATOM 270 CD ARG A 38 −4.253 15.072 −52.101 1.00 23.51 C ATOM 271 NE ARG A 38 −3.219 15.991 −52.594 1.00 24.85 N ATOM 272 CZ ARG A 38 −2.030 16.173 −52.009 1.00 25.56 C ATOM 273 NH1 ARG A 38 −1.158 17.028 −52.524 1.00 26.93 N ATOM 274 NH2 ARG A 38 −1.697 15.502 −50.912 1.00 25.36 N ATOM 275 C ARG A 38 −5.018 12.213 −55.686 1.00 18.91 C ATOM 276 O ARG A 38 −6.016 11.716 −56.182 1.00 18.96 O ATOM 277 N LEU A 39 −3.861 11.569 −55.596 1.00 19.09 N ATOM 278 CA LEU A 39 −3.708 10.186 −56.030 1.00 19.20 C ATOM 279 CB LEU A 39 −2.821 10.132 −57.268 1.00 19.25 C ATOM 280 CG LEU A 39 −2.565 8.776 −57.919 1.00 19.14 C ATOM 281 CD1 LEU A 39 −3.672 8.456 −58.897 1.00 18.93 C ATOM 282 CD2 LEU A 39 −1.230 8.819 −58.639 1.00 19.57 C ATOM 283 C LEU A 39 −3.101 9.334 −54.916 1.00 19.42 C ATOM 284 O LEU A 39 −1.944 9.530 −54.550 1.00 19.82 O ATOM 285 N GLU A 40 −3.884 8.399 −54.374 1.00 19.42 N ATOM 286 CA GLU A 40 −3.405 7.492 −53.323 1.00 19.08 C ATOM 287 CB GLU A 40 −4.510 7.223 −52.288 1.00 19.78 C ATOM 288 CG GLU A 40 −5.000 8.454 −51.518 1.00 20.88 C ATOM 289 CD GLU A 40 −6.265 8.201 −50.662 1.00 21.77 C ATOM 290 OE1 GLU A 40 −6.884 7.102 −50.753 1.00 22.31 O ATOM 291 OE2 GLU A 40 −6.648 9.116 −49.884 1.00 21.32 O ATOM 292 C GLU A 40 −2.951 6.179 −53.960 1.00 18.42 C ATOM 293 O GLU A 40 −3.660 5.630 −54.814 1.00 18.54 O ATOM 294 N GLU A 40 −1.762 5.705 −53.573 1.00 17.46 N ATOM 295 CA GLU A 40 −1.226 4.408 −54.042 1.00 16.82 C ATOM 296 CB ILE A 41 0.136 4.537 −54.736 1.00 16.24 C ATOM 297 CG1 ILE A 41 0.078 5.580 −55.848 1.00 16.54 C ATOM 298 CD1 ILE A 41 1.427 6.108 −56.287 1.00 16.67 C ATOM 299 CG2 ILE A 41 0.561 3.183 −55.273 1.00 15.87 C ATOM 300 C ILE A 41 −1.055 3.397 −52.907 1.00 16.92 C ATOM 301 O ILE A 41 −0.162 3.529 −52.049 1.00 16.63 O ATOM 302 N TYR A 42 −1.902 2.375 −52.934 1.00 16.72 N ATOM 303 CA TYR A 42 −1.865 1.293 −51.972 1.00 16.23 C ATOM 304 CB TYR A 42 −3.278 0.982 −51.515 1.00 16.28 C ATOM 305 CG TYR A 42 −3.962 2.064 −50.724 1.00 16.19 C ATOM 306 CD1 TYR A 42 −4.647 3.090 −51.359 1.00 16.23 C ATOM 307 CE1 TYR A 42 −5.297 4.067 −50.633 1.00 16.31 C ATOM 308 CZ TYR A 42 −5.274 4.016 −49.254 1.00 16.34 C ATOM 309 OH TYR A 42 −5.919 4.982 −48.525 1.00 16.51 O ATOM 310 CE2 TYR A 42 −4.603 3.009 −48.598 1.00 16.22 C ATOM 311 CD2 TYR A 42 −3.961 2.035 −49.335 1.00 16.16 C ATOM 312 C TYR A 42 −1.286 0.032 −52.600 1.00 16.16 C ATOM 313 O TYR A 42 −1.293 −0.125 −53.821 1.00 16.19 O ATOM 314 N VAL A 43 −0.792 −0.863 −51.753 1.00 16.21 N ATOM 315 CA VAL A 43 −0.483 −2.229 −52.152 1.00 16.58 C ATOM 316 CB VAL A 43 0.892 −2.701 −51.603 1.00 16.48 C ATOM 317 CG1 VAL A 43 1.083 −4.193 −51.820 1.00 16.14 C ATOM 318 CG2 VAL A 43 2.033 −1.933 −52.244 1.00 16.53 C ATOM 319 C VAL A 43 −1.560 −3.093 −51.539 1.00 16.83 C ATOM 320 O VAL A 43 −1.840 −2.966 −50.341 1.00 16.44 O ATOM 321 N VAL A 44 −2.167 −3.960 −52.350 1.00 17.67 N ATOM 322 CA VAL A 44 −3.139 −4.952 −51.842 1.00 19.01 C ATOM 323 CB VAL A 44 −3.959 −5.594 −52.984 1.00 18.32 C ATOM 324 CG1 VAL A 44 −5.099 −6.409 −52.417 1.00 18.51 C ATOM 325 CG2 VAL A 44 −4.513 −4.531 −53.907 1.00 17.88 C ATOM 326 C VAL A 44 −2.397 −6.039 −51.042 1.00 19.99 C ATOM 327 O VAL A 44 −1.315 −6.456 −51.440 1.00 20.39 O ATOM 328 N THR A 45 −2.956 −6.474 −49.913 1.00 21.50 N ATOM 329 CA THR A 45 −2.272 −7.447 −49.040 1.00 23.54 C ATOM 330 CB THR A 45 −1.721 −6.802 −47.745 1.00 23.33 C ATOM 331 OG1 THR A 45 −2.680 −5.865 −47.230 1.00 24.12 O ATOM 332 CG2 THR A 45 −0.394 −6.107 −47.993 1.00 22.47 C ATOM 333 C THR A 45 −3.183 −8.612 −48.662 1.00 25.59 C ATOM 334 O THR A 45 −3.306 −9.563 −49.420 1.00 28.20 O ATOM 335 N ALA A 46 −3.809 −8.531 −47.486 1.00 26.36 N ATOM 336 CA ALA A 46 −4.686 −9.588 −46.962 1.00 26.41 C ATOM 337 CB ALA A 46 −4.002 −10.952 −47.024 1.00 25.04 C ATOM 338 C ALA A 46 −5.078 −9.250 −45.524 1.00 27.07 C ATOM 339 O ALA A 46 −4.278 −8.681 −44.766 1.00 27.05 O ATOM 340 N LEU A 49 −4.930 −3.391 −47.266 1.00 15.89 N ATOM 341 CA LEU A 49 −4.219 −2.368 −48.040 1.00 16.33 C ATOM 342 CB LEU A 49 −5.164 −1.269 −48.551 1.00 16.09 C ATOM 343 CG LEU A 49 −6.494 −1.475 −49.276 1.00 16.39 C ATOM 344 CD1 LEU A 49 −7.012 −0.116 −49.720 1.00 16.16 C ATOM 345 CD2 LEU A 49 −6.358 −2.396 −50.477 1.00 16.90 C ATOM 346 C LEU A 49 −3.131 −1.681 −47.217 1.00 16.62 C ATOM 347 O LEU A 49 −3.414 −1.098 −46.171 1.00 16.47 O ATOM 348 N ARG A 50 −1.894 −1.725 −47.707 1.00 16.85 N ATOM 349 CA ARG A 50 −0.827 −0.922 −47.142 1.00 16.87 C ATOM 350 CB ARG A 50 0.458 −1.747 −47.072 1.00 18.25 C ATOM 351 CG ARG A 50 1.740 −0.961 −46.824 1.00 19.73 C ATOM 352 CD ARG A 50 2.925 −1.899 −46.601 1.00 21.58 C ATOM 353 NE ARG A 50 3.240 −2.744 −47.765 1.00 23.27 N ATOM 354 CZ ARG A 50 4.012 −2.364 −48.791 1.00 24.85 C ATOM 355 NH1 ARG A 50 4.555 −1.143 −48.813 1.00 25.26 N ATOM 356 NH2 ARG A 50 4.247 −3.202 −49.801 1.00 24.60 N ATOM 357 C ARG A 50 −0.653 0.337 −48.004 1.00 16.33 C ATOM 358 O ARG A 50 −0.352 0.233 −49.187 1.00 15.97 O ATOM 359 N PRO A 51 −0.895 1.529 −47.420 1.00 16.03 N ATOM 360 CA PRO A 51 −0.627 2.779 −48.103 1.00 15.93 C ATOM 361 CB PRO A 51 −1.022 3.836 −47.071 1.00 15.60 C ATOM 362 CG PRO A 51 −1.027 3.139 −45.774 1.00 15.51 C ATOM 363 CD PRO A 51 −1.512 1.770 −46.108 1.00 16.07 C ATOM 364 C PRO A 51 0.846 2.889 −48.411 1.00 16.28 C ATOM 365 O PRO A 51 1.665 2.475 −47.605 1.00 17.49 O ATOM 366 N VAL A 52 1.191 3.436 −49.566 1.00 16.17 N ATOM 367 CA VAL A 52 2.570 3.462 −49.975 1.00 16.05 C ATOM 368 CB VAL A 52 2.783 2.412 −51.057 1.00 15.96 C ATOM 369 CG1 VAL A 52 3.841 2.833 −52.051 1.00 16.73 C ATOM 370 CG2 VAL A 52 3.145 1.104 −50.402 1.00 16.42 C ATOM 371 C VAL A 52 3.032 4.865 −50.390 1.00 16.75 C ATOM 372 O VAL A 52 4.129 5.295 −50.029 1.00 16.63 O ATOM 373 N LYS A 53 2.176 5.583 −51.116 1.00 17.59 N ATOM 374 CA LYS A 53 2.508 6.900 −51.646 1.00 17.84 C ATOM 375 CB LYS A 53 3.426 6.764 −52.851 1.00 18.04 C ATOM 376 CG LYS A 53 3.829 8.079 −53.492 1.00 17.80 C ATOM 377 CD LYS A 53 4.566 8.948 −52.502 1.00 17.82 C ATOM 378 CE LYS A 53 5.404 9.981 −53.222 1.00 18.20 C ATOM 379 NZ LYS A 53 5.435 11.256 −52.443 1.00 19.40 N ATOM 380 C LYS A 53 1.254 7.616 −52.088 1.00 18.73 C ATOM 381 O LYS A 53 0.414 7.038 −52.790 1.00 18.86 O ATOM 382 N GLU A 54 1.146 8.882 −51.684 1.00 19.21 N ATOM 383 CA GLU A 54 0.078 9.779 −52.111 1.00 18.91 C ATOM 384 CB GLU A 54 −0.794 10.117 −50.907 1.00 19.31 C ATOM 385 CG GLU A 54 −1.981 11.019 −51.205 1.00 20.85 C ATOM 386 CD GLU A 54 −1.824 12.442 −50.669 1.00 21.22 C ATOM 387 OE1 GLU A 54 −2.856 13.142 −50.561 1.00 21.48 O ATOM 388 OE2 GLU A 54 −0.688 12.864 −50.344 1.00 21.10 O ATOM 389 C GLU A 54 0.692 11.048 −52.742 1.00 18.99 C ATOM 390 O GLU A 54 1.616 11.650 −52.184 1.00 19.58 O ATOM 391 N VAL A 55 0.218 11.439 −53.917 1.00 18.94 N ATOM 392 CA VAL A 55 0.718 12.673 −54.550 1.00 19.06 C ATOM 393 CB VAL A 55 1.627 12.410 −55.761 1.00 19.24 C ATOM 394 CG1 VAL A 55 2.975 11.864 −55.304 1.00 19.62 C ATOM 395 CG2 VAL A 55 0.936 11.499 −56.765 1.00 19.33 C ATOM 396 C VAL A 55 −0.399 13.588 −54.997 1.00 19.09 C ATOM 397 O VAL A 55 −1.564 13.181 −55.046 1.00 19.98 O ATOM 398 N GLY A 56 −0.035 14.825 −55.328 1.00 18.29 N ATOM 399 CA GLY A 56 −1.011 15.841 −55.698 1.00 17.00 C ATOM 400 C GLY A 56 −0.713 16.402 −57.059 1.00 16.19 C ATOM 401 O GLY A 56 0.404 16.807 −57.339 1.00 16.18 O ATOM 402 N MET A 57 −1.717 16.395 −57.921 1.00 15.87 N ATOM 403 CA MET A 57 −1.634 17.090 −59.182 1.00 15.36 C ATOM 404 CB MET A 57 −2.694 16.588 −60.142 1.00 16.07 C ATOM 405 CG MET A 57 −2.867 15.091 −60.202 1.00 17.01 C ATOM 406 SD MET A 57 −1.495 14.346 −61.077 1.00 18.54 S ATOM 407 CE MET A 57 −1.605 15.162 −62.680 1.00 17.61 C ATOM 408 C MET A 57 −1.935 18.540 −58.931 1.00 14.64 C ATOM 409 O MET A 57 −2.617 18.888 −57.973 1.00 14.20 O ATOM 410 N TYR A 58 −1.415 19.383 −59.806 1.00 14.28 N ATOM 411 CA TYR A 58 −2.023 20.671 −60.063 1.00 13.71 C ATOM 412 CB TYR A 58 −0.977 21.674 −60.561 1.00 13.50 C ATOM 413 CG TYR A 58 0.118 22.015 −59.579 1.00 13.16 C ATOM 414 CD1 TYR A 58 −0.065 21.871 −58.216 1.00 13.18 C ATOM 415 CE1 TYR A 58 0.940 22.200 −57.322 1.00 13.36 C ATOM 416 CZ TYR A 58 2.146 22.691 −57.796 1.00 13.36 C ATOM 417 OH TYR A 58 3.154 23.027 −56.916 1.00 13.44 O ATOM 418 CE2 TYR A 58 2.342 22.859 −59.148 1.00 13.20 C ATOM 419 CD2 TYR A 58 1.331 22.522 −60.026 1.00 13.29 C ATOM 420 C TYR A 58 −3.086 20.413 −61.135 1.00 13.36 C ATOM 421 O TYR A 58 −2.937 20.820 −62.300 1.00 13.06 O ATOM 422 N GLY A 59 −4.145 19.706 −60.740 1.00 13.13 N ATOM 423 CA GLY A 59 −5.161 19.261 −61.690 1.00 13.12 C ATOM 424 C GLY A 59 −6.279 18.400 −61.130 1.00 13.30 C ATOM 425 O GLY A 59 −6.064 17.554 −60.247 1.00 13.50 O ATOM 426 N LYS A 60 −7.487 18.622 −61.637 1.00 13.17 N ATOM 427 CA LYS A 60 −8.581 17.712 −61.389 1.00 13.09 C ATOM 428 CB LYS A 60 −9.909 18.381 −61.714 1.00 13.32 C ATOM 429 CG LYS A 60 −10.312 19.480 −60.730 1.00 13.94 C ATOM 430 CD LYS A 60 −11.657 20.123 −61.084 1.00 14.12 C ATOM 431 CE LYS A 60 −12.830 19.180 −60.824 1.00 14.11 C ATOM 432 NZ LYS A 60 −13.199 19.143 −59.384 1.00 14.26 N ATOM 433 C LYS A 60 −8.373 16.473 −62.252 1.00 13.29 C ATOM 434 O LYS A 60 −8.359 16.561 −63.490 1.00 12.95 O ATOM 435 N ILE A 61 −8.165 15.324 −61.601 1.00 13.66 N ATOM 436 CA ILE A 61 −8.001 14.052 −62.322 1.00 14.04 C ATOM 437 CB ILE A 61 −7.565 12.892 −61.396 1.00 13.83 C ATOM 438 CG1 ILE A 61 −6.159 13.138 −60.833 1.00 13.72 C ATOM 439 CD1 ILE A 61 −5.883 12.404 −59.536 1.00 13.45 C ATOM 440 CG2 ILE A 61 −7.643 11.551 −62.122 1.00 13.61 C ATOM 441 C ILE A 61 −9.323 13.703 −62.984 1.00 14.51 C ATOM 442 O ILE A 61 −10.333 13.522 −62.299 1.00 14.52 O ATOM 443 N ALA A 62 −9.301 13.637 −64.315 1.00 14.99 N ATOM 444 CA ALA A 62 −10.483 13.351 −65.122 1.00 15.40 C ATOM 445 CB ALA A 62 −10.713 14.473 −66.114 1.00 15.29 C ATOM 446 C ALA A 62 −10.384 12.004 −65.864 1.00 16.28 C ATOM 447 O ALA A 62 −11.405 11.447 −66.277 1.00 17.15 O ATOM 448 N VAL A 63 −9.162 11.508 −66.071 1.00 16.28 N ATOM 449 CA VAL A 63 −8.930 10.196 −66.674 1.00 16.31 C ATOM 450 CB VAL A 63 −8.684 10.286 −68.193 1.00 15.95 C ATOM 451 CG1 VAL A 63 −8.443 8.904 −68.787 1.00 15.64 C ATOM 452 CG2 VAL A 63 −9.838 10.973 −68.896 1.00 16.07 C ATOM 453 C VAL A 63 −7.683 9.601 −66.033 1.00 17.40 C ATOM 454 O VAL A 63 −6.681 10.308 −65.843 1.00 18.75 O ATOM 455 N MET A 64 −7.720 8.310 −65.722 1.00 17.20 N ATOM 456 CA MET A 64 −6.615 7.672 −65.044 1.00 17.41 C ATOM 457 CB MET A 64 −6.715 7.947 −63.542 1.00 17.02 C ATOM 458 CG MET A 64 −5.728 7.183 −62.686 1.00 17.37 C ATOM 459 SD MET A 64 −6.143 7.123 −60.932 1.00 17.40 S ATOM 460 CE MET A 64 −7.354 5.806 −60.929 1.00 17.99 C ATOM 461 C MET A 64 −6.638 6.175 −65.354 1.00 18.36 C ATOM 462 O MET A 64 −7.488 5.447 −64.860 1.00 18.73 O ATOM 463 N GLU A 65 −5.714 5.723 −66.191 1.00 19.30 N ATOM 464 CA GLU A 65 −5.663 4.323 −66.575 1.00 20.87 C ATOM 465 CB GLU A 65 −6.141 4.140 −68.020 1.00 22.24 C ATOM 466 CG GLU A 65 −7.640 4.327 −68.226 1.00 24.79 C ATOM 467 CD GLU A 65 −8.517 3.265 −67.538 1.00 27.35 C ATOM 468 OE1 GLU A 65 −8.029 2.139 −67.205 1.00 27.72 O ATOM 469 OE2 GLU A 65 −9.726 3.561 −67.347 1.00 28.00 O ATOM 470 C GLU A 65 −4.263 3.746 −66.427 1.00 21.45 C ATOM 471 O GLU A 65 −3.270 4.459 −66.595 1.00 22.49 O ATOM 472 N LEU A 66 −4.187 2.452 −66.121 1.00 20.92 N ATOM 473 CA LEU A 66 −2.923 1.742 −66.156 1.00 21.07 C ATOM 474 CB LEU A 66 −2.810 0.804 −64.962 1.00 21.30 C ATOM 475 CG LEU A 66 −2.585 1.454 −63.595 1.00 21.62 C ATOM 476 CD1 LEU A 66 −2.397 0.384 −62.532 1.00 20.76 C ATOM 477 CD2 LEU A 66 −1.390 2.402 −63.623 1.00 21.50 C ATOM 478 C LEU A 66 −2.762 0.965 −67.463 1.00 21.33 C ATOM 479 O LEU A 66 −3.730 0.423 −67.996 1.00 21.48 O ATOM 480 N PHE A 67 −1.538 0.907 −67.976 1.00 21.23 N ATOM 481 CA PHE A 67 −1.270 0.192 −69.212 1.00 21.64 C ATOM 482 CB PHE A 67 −1.595 1.086 −70.401 1.00 21.19 C ATOM 483 CG PHE A 67 −0.642 2.232 −70.576 1.00 20.82 C ATOM 484 CD1 PHE A 67 −0.748 3.372 −69.787 1.00 20.94 C ATOM 485 CE1 PHE A 67 0.140 4.428 −69.947 1.00 20.56 C ATOM 486 CZ PHE A 67 1.136 4.353 −70.901 1.00 19.99 C ATOM 487 CE2 PHE A 67 1.249 3.222 −71.691 1.00 20.14 C ATOM 488 CD2 PHE A 67 0.366 2.172 −71.530 1.00 20.34 C ATOM 489 C PHE A 67 0.188 −0.249 −69.268 1.00 23.05 C ATOM 490 O PHE A 67 1.050 0.391 −68.659 1.00 23.15 O ATOM 491 N ARG A 68 0.469 −1.338 −69.991 1.00 24.67 N ATOM 492 CA ARG A 68 1.855 −1.792 −70.153 1.00 26.52 C ATOM 493 CB ARG A 68 2.066 −3.217 −69.648 1.00 26.18 C ATOM 494 CG ARG A 68 3.529 −3.495 −69.327 1.00 26.87 C ATOM 495 CD ARG A 68 3.759 −4.910 −68.843 1.00 28.29 C ATOM 496 NE ARG A 68 3.047 −5.195 −67.595 1.00 29.60 N ATOM 497 CZ ARG A 68 3.634 −5.558 −66.462 1.00 29.23 C ATOM 498 NH1 ARG A 68 4.947 −5.695 −66.410 1.00 29.16 N ATOM 499 NH2 ARG A 68 2.902 −5.801 −65.385 1.00 29.71 N ATOM 500 C ARG A 68 2.366 −1.690 −71.573 1.00 28.42 C ATOM 501 O ARG A 68 1.977 −2.477 −72.425 1.00 28.33 O ATOM 502 N PRO A 69 3.281 −0.742 −71.823 1.00 31.15 N ATOM 503 CA PRO A 69 3.901 −0.696 −73.140 1.00 33.29 C ATOM 504 CB PRO A 69 4.782 0.560 −73.077 1.00 33.00 C ATOM 505 CG PRO A 69 5.081 0.744 −71.632 1.00 32.69 C ATOM 506 CD PRO A 69 3.897 0.209 −70.877 1.00 32.13 C ATOM 507 C PRO A 69 4.758 −1.939 −73.368 1.00 35.12 C ATOM 508 O PRO A 69 5.312 −2.487 −72.419 1.00 36.02 O ATOM 509 N LYS A 70 4.843 −2.376 −74.622 1.00 37.95 N ATOM 510 CA LYS A 70 5.699 −3.490 −75.032 1.00 38.43 C ATOM 511 CB LYS A 70 5.707 −3.580 −76.562 1.00 40.38 C ATOM 512 CG LYS A 70 5.855 −4.990 −77.119 1.00 42.56 C ATOM 513 CD LYS A 70 6.124 −4.970 −78.624 1.00 43.16 C ATOM 514 CE LYS A 70 7.334 −4.107 −78.982 1.00 43.72 C ATOM 515 NZ LYS A 70 8.585 −4.529 −78.284 1.00 42.23 N ATOM 516 C LYS A 70 7.131 −3.333 −74.492 1.00 37.13 C ATOM 517 O LYS A 70 7.695 −2.234 −74.499 1.00 34.62 O ATOM 518 N GLY A 71 7.698 −4.437 −74.006 1.00 37.86 N ATOM 519 CA GLY A 71 9.049 −4.443 −73.458 1.00 38.73 C ATOM 520 C GLY A 71 9.233 −3.420 −72.352 1.00 40.73 C ATOM 521 O GLY A 71 10.205 −2.666 −72.343 1.00 42.01 O ATOM 522 N GLU A 72 8.273 −3.374 −71.436 1.00 41.59 N ATOM 523 CA GLU A 72 8.399 −2.596 −70.208 1.00 41.02 C ATOM 524 CB GLU A 72 7.412 −1.434 −70.201 1.00 41.92 C ATOM 525 CG GLU A 72 7.697 −0.361 −69.156 1.00 44.49 C ATOM 526 CD GLU A 72 8.362 0.885 −69.729 1.00 46.15 C ATOM 527 OE1 GLU A 72 8.813 1.727 −68.926 1.00 46.10 O ATOM 528 OE2 GLU A 72 8.431 1.035 −70.973 1.00 47.23 O ATOM 529 C GLU A 72 8.129 −3.550 −69.043 1.00 40.25 C ATOM 530 O GLU A 72 7.348 −4.501 −69.175 1.00 39.52 O ATOM 531 N SER A 73 8.780 −3.298 −67.911 1.00 39.18 N ATOM 532 CA SER A 73 8.810 −4.265 −66.809 1.00 39.60 C ATOM 533 CB SER A 73 10.149 −4.194 −66.052 1.00 42.24 C ATOM 534 OG SER A 73 10.672 −2.871 −66.025 1.00 43.46 O ATOM 535 C SER A 73 7.620 −4.179 −65.838 1.00 38.72 C ATOM 536 O SER A 73 7.283 −5.180 −65.187 1.00 38.17 O ATOM 537 N LYS A 74 7.002 −2.989 −65.757 1.00 35.19 N ATOM 538 CA LYS A 74 5.819 −2.712 −64.923 1.00 31.04 C ATOM 539 CB LYS A 74 6.239 −2.206 −63.543 1.00 31.01 C ATOM 540 CG LYS A 74 7.492 −1.358 −63.570 1.00 31.73 C ATOM 541 CD LYS A 74 7.680 −0.535 −62.309 1.00 32.50 C ATOM 542 CE LYS A 74 8.567 0.663 −62.631 1.00 33.98 C ATOM 543 NZ LYS A 74 9.203 1.275 −61.436 1.00 34.98 N ATOM 544 C LYS A 74 4.929 −1.674 −65.612 1.00 29.38 C ATOM 545 O LYS A 74 5.381 −0.984 −66.522 1.00 28.62 O ATOM 546 N ASP A 75 3.672 −1.557 −65.169 1.00 27.74 N ATOM 547 CA ASP A 75 2.702 −0.658 −65.804 1.00 25.57 C ATOM 548 CB ASP A 75 1.298 −0.833 −65.211 1.00 25.78 C ATOM 549 CG ASP A 75 0.796 −2.261 −65.285 1.00 26.85 C ATOM 550 OD1 ASP A 75 1.487 −3.112 −65.888 1.00 26.71 O ATOM 551 OD2 ASP A 75 −0.298 −2.538 −64.730 1.00 27.57 O ATOM 552 C ASP A 75 3.106 0.790 −65.647 1.00 24.44 C ATOM 553 O ASP A 75 3.718 1.166 −64.649 1.00 24.83 O ATOM 554 N LEU A 76 2.762 1.598 −66.647 1.00 22.78 N ATOM 555 CA LEU A 76 2.788 3.052 −66.522 1.00 20.94 C ATOM 556 CB LEU A 76 3.443 3.679 −67.747 1.00 20.70 C ATOM 557 CG LEU A 76 4.871 3.232 −68.065 1.00 20.35 C ATOM 558 CD1 LEU A 76 5.254 3.673 −69.461 1.00 20.15 C ATOM 559 CD2 LEU A 76 5.861 3.774 −67.049 1.00 20.45 C ATOM 560 C LEU A 76 1.358 3.593 −66.323 1.00 20.28 C ATOM 561 O LEU A 76 0.369 2.859 −66.492 1.00 20.28 O ATOM 562 N LEU A 77 1.257 4.868 −65.951 1.00 18.91 N ATOM 563 CA LEU A 77 −0.016 5.465 −65.577 1.00 17.83 C ATOM 564 CB LEU A 77 0.022 5.871 −64.106 1.00 17.81 C ATOM 565 CG LEU A 77 −1.189 6.569 −63.475 1.00 18.16 C ATOM 566 CD1 LEU A 77 −2.401 5.654 −63.369 1.00 17.75 C ATOM 567 CD2 LEU A 77 −0.796 7.075 −62.101 1.00 17.99 C ATOM 568 C LEU A 77 −0.324 6.676 −66.436 1.00 17.28 C ATOM 569 O LEU A 77 0.460 7.618 −66.482 1.00 17.17 O ATOM 570 N PHE A 78 −1.463 6.653 −67.122 1.00 16.86 N ATOM 571 CA PHE A 78 −1.908 7.823 −67.881 1.00 16.56 C ATOM 572 CB PHE A 78 −2.521 7.423 −69.222 1.00 16.27 C ATOM 573 CG PHE A 78 −3.109 8.580 −69.978 1.00 16.08 C ATOM 574 CD1 PHE A 78 −2.283 9.551 −70.546 1.00 16.00 C ATOM 575 CE1 PHE A 78 −2.823 10.620 −71.240 1.00 15.79 C ATOM 576 CZ PHE A 78 −4.202 10.736 −71.369 1.00 15.77 C ATOM 577 CE2 PHE A 78 −5.035 9.784 −70.810 1.00 15.73 C ATOM 578 CD2 PHE A 78 −4.487 8.712 −70.113 1.00 15.99 C ATOM 579 C PHE A 78 −2.912 8.659 −67.098 1.00 16.28 C ATOM 580 O PHE A 78 −3.903 8.133 −66.586 1.00 16.53 O ATOM 581 N PHE A 78 −2.651 9.956 −67.003 1.00 15.55 N ATOM 582 CA PHE A 78 −3.604 10.855 −66.381 1.00 15.37 C ATOM 580 O PHE A 78 −3.903 8.133 −66.586 1.00 16.53 O ATOM 581 N ILE A 79 −2.651 9.956 −67.003 1.00 15.55 N ATOM 582 CA ILE A 79 −3.604 10.855 −66.381 1.00 15.37 C ATOM 583 CB ILE A 79 −3.027 11.597 −65.151 1.00 15.42 C ATOM 584 CG1 ILE A 79 −2.470 10.620 −64.109 1.00 15.66 C ATOM 585 CD1 ILE A 79 −3.519 9.975 −63.237 1.00 15.63 C ATOM 586 CG2 ILE A 79 −4.087 12.483 −64.516 1.00 14.95 C ATOM 587 C ILE A 79 −3.973 11.892 −67.394 1.00 15.22 C ATOM 588 O ILE A 79 −3.116 12.352 −68.154 1.00 15.76 O ATOM 589 N LEU A 80 −5.248 12.258 −67.405 1.00 14.63 N ATOM 590 CA LEU A 80 −5.697 13.452 −68.092 1.00 14.17 C ATOM 591 CB LEU A 80 −6.605 13.086 −69.257 1.00 14.25 C ATOM 592 CG LEU A 80 −7.206 14.230 −70.064 1.00 14.17 C ATOM 593 CD1 LEU A 80 −6.189 14.783 −71.053 1.00 14.21 C ATOM 594 CD2 LEU A 80 −8.433 13.708 −70.779 1.00 14.07 C ATOM 595 C LEU A 80 −6.450 14.306 −67.098 1.00 13.83 C ATOM 596 O LEU A 80 −7.366 13.811 −66.424 1.00 13.85 O ATOM 597 N THR A 81 −6.064 15.577 −66.997 1.00 13.26 N ATOM 598 CA THR A 81 −6.741 16.515 −66.094 1.00 13.11 C ATOM 599 CB THR A 81 −5.778 17.579 −65.573 1.00 13.38 C ATOM 600 OG1 THR A 81 −5.349 18.393 −66.678 1.00 13.95 O ATOM 601 CG2 THR A 81 −4.570 16.937 −64.883 1.00 13.07 C ATOM 602 C THR A 81 −7.902 17.241 −66.780 1.00 12.73 C ATOM 603 O THR A 81 −8.002 17.265 −68.008 1.00 12.80 O ATOM 604 N ALA A 82 −8.765 17.849 −65.980 1.00 12.33 N ATOM 605 CA ALA A 82 −9.926 18.548 −66.501 1.00 12.21 C ATOM 606 CB ALA A 82 −10.780 19.063 −65.364 1.00 11.82 C ATOM 607 C ALA A 82 −9.510 19.691 −67.421 1.00 12.54 C ATOM 608 O ALA A 82 −10.281 20.104 −68.286 1.00 12.73 O ATOM 609 N LYS A 83 −8.283 20.184 −67.240 1.00 12.76 N ATOM 610 CA LYS A 83 −7.733 21.256 −68.072 1.00 12.87 C ATOM 611 CB LYS A 83 −6.882 22.220 −67.253 1.00 12.57 C ATOM 612 CG LYS A 83 −7.712 23.277 −66.563 1.00 12.27 C ATOM 613 CD LYS A 83 −6.862 24.241 −65.767 1.00 12.09 C ATOM 614 CE LYS A 83 −7.761 25.176 −64.995 1.00 12.25 C ATOM 615 NZ LYS A 83 −7.043 26.375 −64.526 1.00 12.05 N ATOM 616 C LYS A 83 −6.936 20.730 −69.243 1.00 13.50 C ATOM 617 O LYS A 83 −6.251 21.495 −69.932 1.00 13.97 O ATOM 618 N TYR A 84 −7.038 19.422 −69.468 1.00 14.00 N ATOM 619 CA TYR A 84 −6.518 18.775 −70.670 1.00 14.21 C ATOM 620 CB TYR A 84 −6.957 19.525 −71.922 1.00 14.06 C ATOM 621 CG TYR A 84 −8.469 19.551 −72.134 1.00 14.22 C ATOM 622 CD1 TYR A 84 −9.149 18.401 −72.549 1.00 14.34 C ATOM 623 CE1 TYR A 84 −10.512 18.409 −72.761 1.00 14.07 C ATOM 624 CZ TYR A 84 −11.216 19.570 −72.572 1.00 14.10 C ATOM 625 OH TYR A 84 −12.574 19.531 −72.800 1.00 14.76 O ATOM 626 CE2 TYR A 84 −10.578 20.736 −72.172 1.00 13.78 C ATOM 627 CD2 TYR A 84 −9.212 20.723 −71.955 1.00 13.80 C ATOM 628 C TYR A 84 −5.012 18.632 −70.622 1.00 14.85 C ATOM 629 O TYR A 84 −4.355 18.585 −71.655 1.00 15.24 O ATOM 630 N ASN A 85 −4.471 18.555 −69.410 1.00 15.35 N ATOM 631 CA ASN A 85 −3.086 18.186 −69.221 1.00 15.87 C ATOM 632 CB ASN A 85 −2.579 18.664 −67.866 1.00 16.36 C ATOM 633 CG ASN A 85 −2.848 20.130 −67.625 1.00 16.90 C ATOM 634 OD1 ASN A 85 −3.724 20.486 −66.833 1.00 17.34 O ATOM 635 ND2 ASN A 85 −2.103 20.996 −68.316 1.00 16.93 N ATOM 636 C ASN A 85 −2.981 16.687 −69.260 1.00 16.17 C ATOM 637 O ASN A 85 −3.536 16.012 −68.404 1.00 16.34 O ATOM 638 N ALA A 86 −2.289 16.165 −70.265 1.00 16.89 N ATOM 639 CA ALA A 86 −1.962 14.743 −70.313 1.00 17.48 C ATOM 640 CB ALA A 86 −1.994 14.233 −71.747 1.00 17.21 C ATOM 641 C ALA A 86 −0.602 14.482 −69.699 1.00 17.82 C ATOM 642 O ALA A 86 0.253 15.369 −69.659 1.00 17.63 O ATOM 643 N CYS A 87 −0.408 13.269 −69.214 1.00 18.91 N ATOM 644 CA CYS A 87 0.926 12.804 −68.868 1.00 20.48 C ATOM 645 CB CYS A 87 1.411 13.458 −67.572 1.00 21.28 C ATOM 646 SG CYS A 87 0.420 13.012 −66.133 1.00 23.89 S ATOM 647 C CYS A 87 0.991 11.280 −68.748 1.00 21.10 C ATOM 648 O CYS A 87 2.205 10.737 −68.883 1.00 20.33 N ATOM 649 N ILE A 88 2.488 9.361 −68.520 1.00 19.91 C ATOM 650 CA ILE A 88 3.037 8.556 −69.712 1.00 19.63 C ATOM 651 CB ILE A 88 3.037 8.556 −69.712 1.00 19.63 C ATOM 652 CG1 ILE A 88 1.955 8.415 −70.784 1.00 19.60 C ATOM 653 CD1 ILE A 88 2.481 8.083 −72.163 1.00 19.48 C ATOM 654 CG2 ILE A 88 3.494 7.169 −69.276 1.00 19.49 C ATOM 655 C ILE A 88 3.457 9.370 −67.340 1.00 20.40 C ATOM 656 O ILE A 88 4.445 10.105 −67.351 1.00 20.21 O ATOM 657 N LEU A 89 3.149 8.555 −66.325 1.00 21.14 N ATOM 658 CA LEU A 89 3.863 8.548 −65.037 1.00 21.61 C ATOM 659 CB LEU A 89 2.947 9.044 −63.917 1.00 21.22 C ATOM 660 CG LEU A 89 2.298 10.413 −64.100 1.00 21.49 C ATOM 661 CD1 LEU A 89 1.230 10.608 −63.036 1.00 21.52 C ATOM 662 CD2 LEU A 89 3.316 11.547 −64.080 1.00 20.93 C ATOM 663 C LEU A 89 4.412 7.177 −64.645 1.00 22.25 C ATOM 664 O LEU A 89 3.797 6.146 −64.921 1.00 22.05 O ATOM 665 N GLU A 90 5.562 7.189 −63.973 1.00 23.53 N ATOM 666 CA GLU A 90 6.244 5.974 −63.535 1.00 24.36 C ATOM 667 CB GLU A 90 7.516 5.743 −64.371 1.00 25.04 C ATOM 668 CG GLU A 90 8.437 4.657 −63.833 1.00 27.32 C ATOM 669 CD GLU A 90 9.446 4.123 −64.856 1.00 29.81 C ATOM 670 OE1 GLU A 90 10.132 4.936 −65.530 1.00 30.52 O ATOM 671 OE2 GLU A 90 9.579 2.871 −64.960 1.00 30.18 O ATOM 672 C GLU A 90 6.588 6.086 −62.062 1.00 24.23 C ATOM 673 O GLU A 90 7.006 7.138 −61.594 1.00 23.97 O ATOM 674 N TYR A 91 6.397 4.992 −61.339 1.00 25.16 N ATOM 675 CA TYR A 91 6.792 4.885 −59.938 1.00 25.94 C ATOM 676 CB TYR A 91 5.949 3.794 −59.280 1.00 25.62 C ATOM 677 CG TYR A 91 6.065 3.653 −57.774 1.00 25.57 C ATOM 678 CD1 TYR A 91 6.990 2.785 −57.207 1.00 25.52 C ATOM 679 CE1 TYR A 91 7.080 2.630 −55.840 1.00 25.88 C ATOM 680 CZ TYR A 91 6.221 3.332 −55.012 1.00 26.31 C ATOM 681 OH TYR A 91 6.311 3.178 −53.640 1.00 26.59 O ATOM 682 CE2 TYR A 91 5.280 4.186 −55.549 1.00 25.81 C ATOM 683 CD2 TYR A 91 5.200 4.332 −56.923 1.00 25.80 C ATOM 684 C TYR A 91 8.271 4.522 −59.851 1.00 27.65 C ATOM 685 O TYR A 91 8.771 3.734 −60.657 1.00 27.72 O ATOM 686 N LYS A 92 8.968 5.099 −58.876 1.00 30.26 N ATOM 687 CA LYS A 92 10.364 4.758 −58.598 1.00 31.87 C ATOM 688 CB LYS A 92 11.303 5.808 −59.195 1.00 33.60 C ATOM 689 CG LYS A 92 11.576 5.666 −60.683 1.00 36.58 C ATOM 690 CD LYS A 92 12.145 4.291 −61.029 1.00 39.45 C ATOM 691 CE LYS A 92 12.086 4.024 −62.531 1.00 40.32 C ATOM 692 NZ LYS A 92 11.629 2.630 −62.819 1.00 40.98 N ATOM 693 C LYS A 92 10.593 4.696 −57.096 1.00 33.74 C ATOM 694 O LYS A 92 10.348 5.684 −56.392 1.00 33.72 O ATOM 695 N GLN A 93 11.054 3.542 −56.606 1.00 35.51 N ATOM 696 CA GLN A 93 11.507 3.407 −55.209 1.00 35.80 C ATOM 697 CB GLN A 93 11.491 1.944 −54.752 1.00 36.21 C ATOM 698 CG GLN A 93 11.582 1.746 −53.241 1.00 36.09 C ATOM 699 CD GLN A 93 10.221 1.640 −52.563 1.00 36.63 C ATOM 700 OE1 GLN A 93 9.197 2.040 −53.123 1.00 37.34 O ATOM 701 NE2 GLN A 93 10.206 1.092 −51.351 1.00 35.70 N ATOM 702 C GLN A 93 12.918 3.971 −55.068 1.00 36.68 C ATOM 703 O GLN A 93 13.897 3.319 −55.438 1.00 37.43 O ATOM 704 N SER A 97 13.490 8.811 −51.448 1.00 29.35 N ATOM 705 CA SER A 97 13.044 7.434 −51.272 1.00 29.85 C ATOM 706 CB SER A 97 12.416 7.236 −49.879 1.00 30.84 C ATOM 707 CG SER A 97 12.771 5.973 −49.324 1.00 31.74 O ATOM 708 C SER A 97 12.068 7.017 −52.387 1.00 29.36 C ATOM 709 O SER A 97 12.340 6.042 −53.101 1.00 28.29 O ATOM 710 N ILE A 98 10.947 7.750 −52.531 1.00 27.91 N ATOM 711 CA ILE A 98 9.978 7.513 −53.632 1.00 27.53 C ATOM 712 CB ILE A 98 8.614 6.971 −53.140 1.00 26.33 C ATOM 713 CG1 ILE A 98 8.787 5.812 −52.168 1.00 25.31 C ATOM 714 CD1 ILE A 98 7.518 5.478 −51.426 1.00 25.67 C ATOM 715 CG2 ILE A 98 7.756 6.542 −54.326 1.00 25.63 C ATOM 716 C ILE A 98 9.687 8.743 −54.503 1.00 28.34 C ATOM 717 O ILE A 98 9.258 9.790 −54.005 1.00 28.48 O ATOM 718 N ASP A 99 9.897 8.590 −55.808 1.00 29.68 N ATOM 719 CA ASP A 99 9.538 9.620 −56.786 1.00 30.53 C ATOM 720 CB ASP A 99 10.751 10.051 −57.633 1.00 33.48 C ATOM 721 CG ASP A 99 12.007 10.308 −56.809 1.00 36.29 C ATOM 722 OD1 ASP A 99 12.512 9.360 −56.159 1.00 37.80 O ATOM 723 OD2 ASP A 99 12.523 11.451 −56.859 1.00 37.58 O ATOM 724 C ASP A 99 8.481 9.073 −57.739 1.00 28.89 C ATOM 725 O ASP A 99 8.511 7.892 −58.093 1.00 29.01 O ATOM 726 N ILE A 100 7.554 9.935 −58.153 1.00 26.65 N ATOM 727 CA ILE A 100 6.740 9.686 −59.338 1.00 25.33 C ATOM 728 CB ILE A 100 5.255 9.975 −59.082 1.00 24.53 C ATOM 729 CG1 ILE A 100 4.731 8.984 −58.042 1.00 24.62 C ATOM 730 CD1 ILE A 100 3.291 9.189 −57.641 1.00 25.31 C ATOM 731 CG2 ILE A 100 4.466 9.876 −60.383 1.00 23.67 C ATOM 732 C ILE A 100 7.271 10.556 −60.470 1.00 24.83 C ATOM 733 O ILE A 100 7.345 11.778 −60.330 1.00 25.68 O ATOM 734 N ILE A 101 7.661 9.939 −61.582 1.00 23.60 N ATOM 735 CA ILE A 101 8.349 10.696 −62.630 1.00 23.30 C ATOM 736 CB ILE A 101 9.782 10.182 −62.898 1.00 24.02 C ATOM 737 CG1 ILE A 101 9.762 8.803 −63.562 1.00 24.01 C ATOM 738 CD1 ILE A 101 11.110 8.116 −63.584 1.00 25.13 C ATOM 739 CG2 ILE A 101 10.601 10.197 −61.605 1.00 24.71 C ATOM 740 C ILE A 101 7.560 10.831 −63.922 1.00 22.24 C ATOM 741 O ILE A 101 6.741 9.971 −64.249 1.00 21.69 O ATOM 742 N THR A 102 7.815 11.919 −64.641 1.00 21.27 N ATOM 743 CA THR A 102 7.065 12.239 −65.847 1.00 21.26 C ATOM 744 CB THR A 102 6.762 13.740 −65.927 1.00 20.65 C ATOM 745 OG1 THR A 102 6.144 14.153 −64.709 1.00 20.56 O ATOM 746 CG2 THR A 102 5.841 14.050 −67.097 1.00 20.12 C ATOM 747 C THR A 102 7.782 11.775 −67.117 1.00 21.84 C ATOM 748 O THR A 102 8.773 12.380 −67.558 1.00 21.81 O ATOM 749 N ARG A 103 7.262 10.701 −67.701 1.00 22.07 N ATOM 750 CA ARG A 103 7.815 10.141 −68.920 1.00 22.65 C ATOM 751 CB ARG A 103 7.335 8.703 −69.092 1.00 23.13 C ATOM 752 CG ARG A 103 7.925 7.755 −68.069 1.00 24.69 C ATOM 753 CD ARG A 103 9.306 7.277 −68.487 1.00 25.58 C ATOM 754 NE ARG A 103 9.200 6.243 −69.512 1.00 26.02 N ATOM 755 CZ ARG A 103 9.120 4.941 −69.253 1.00 26.57 C ATOM 756 NH1 ARG A 103 9.153 4.496 −68.001 1.00 26.13 N ATOM 757 NH2 ARG A 103 9.023 4.078 −70.250 1.00 27.75 N ATOM 758 C ARG A 103 7.422 10.979 −70.130 1.00 22.68 C ATOM 759 O ARG A 103 8.220 11.182 −71.046 1.00 22.88 O ATOM 760 N ALA A 104 6.186 11.466 −70.114 1.00 21.99 N ATOM 761 CA ALA A 104 5.613 12.173 −71.234 1.00 21.21 C ATOM 762 CB ALA A 104 4.939 11.191 −72.167 1.00 21.02 C ATOM 763 C ALA A 104 4.599 13.144 −70.690 1.00 21.15 C ATOM 764 O ALA A 104 4.031 12.898 −69.631 1.00 21.85 O ATOM 765 N HIS A 105 4.375 14.250 −71.396 1.00 20.67 N ATOM 766 CA HIS A 105 3.324 15.196 −71.016 1.00 20.08 C ATOM 767 CB HIS A 105 3.642 15.874 −69.687 1.00 20.60 C ATOM 768 CG HIS A 105 4.629 17.006 −69.802 1.00 21.11 C ATOM 769 ND1 HIS A 105 5.954 16.800 −69.966 1.00 21.52 N ATOM 770 CE1 HIS A 105 6.583 17.990 −70.036 1.00 21.81 C ATOM 771 NE2 HIS A 105 5.656 18.959 −69.926 1.00 21.81 N ATOM 772 CD2 HIS A 105 4.443 18.387 −69.779 1.00 21.08 C ATOM 773 C HIS A 105 3.083 16.229 −72.065 1.00 19.22 C ATOM 774 O HIS A 105 3.964 16.542 −72.855 1.00 19.43 O ATOM 775 N GLY A 106 1.879 16.779 −72.060 1.00 18.30 N ATOM 776 CA GLY A 106 1.522 17.839 −72.970 1.00 17.95 C ATOM 777 C GLY A 106 0.055 18.174 −72.884 1.00 17.69 C ATOM 778 O GLY A 106 −0.754 17.349 −72.452 1.00 17.54 O ATOM 779 N ASN A 107 −0.299 19.385 −73.305 1.00 17.44 N ATOM 780 CA ASN A 107 −1.686 19.793 −73.251 1.00 17.36 C ATOM 781 CB ASN A 107 −1.815 21.265 −72.897 1.00 16.68 C ATOM 782 CG ASN A 107 −3.217 21.618 −72.481 1.00 16.91 C ATOM 783 OD1 ASN A 107 −4.099 21.748 −73.323 1.00 17.30 O ATOM 784 ND2 ASN A 107 −3.446 21.731 −71.174 1.00 16.82 N ATOM 785 C ASN A 107 −2.488 19.445 −74.508 1.00 17.78 C ATOM 786 O ASN A 107 −2.256 20.003 −75.571 1.00 18.44 O ATOM 787 N VAL A 108 −3.447 18.535 −74.364 1.00 18.34 N ATOM 788 CA VAL A 108 −4.233 18.028 −75.496 1.00 18.94 C ATOM 789 CB VAL A 108 −4.666 16.563 −75.274 1.00 18.38 C ATOM 790 CG1 VAL A 108 −3.453 15.634 −75.270 1.00 17.82 C ATOM 791 CG2 VAL A 108 −5.476 16.436 −73.988 1.00 18.32 C ATOM 792 C VAL A 108 −5.475 18.861 −75.836 1.00 20.41 C ATOM 793 O VAL A 108 −6.387 18.376 −76.501 1.00 20.72 O ATOM 794 N GLN A 109 −5.514 20.112 −75.391 1.00 22.38 N ATOM 795 CA GLN A 109 −6.621 20.997 −75.731 1.00 23.63 C ATOM 796 CB GLN A 109 −6.537 22.285 −74.927 1.00 24.33 C ATOM 797 CG GLN A 109 −7.580 23.317 −75.304 1.00 25.70 C ATOM 798 CD GLN A 109 −8.071 24.084 −74.106 1.00 27.11 C ATOM 799 OE1 GLN A 109 −7.267 24.576 −73.306 1.00 28.84 O ATOM 800 NE2 GLN A 109 −9.397 24.178 −73.955 1.00 26.37 N ATOM 801 C GLN A 109 −6.643 21.327 −77.223 1.00 24.51 C ATOM 802 O GLN A 109 −5.612 21.277 −77.905 1.00 23.56 O ATOM 803 N ASP A 110 −7.836 21.653 −77.712 1.00 25.74 N ATOM 804 CA ASP A 110 −8.016 22.170 −79.049 1.00 26.80 C ATOM 805 CB ASP A 110 −8.933 21.248 −79.847 1.00 26.77 C ATOM 806 CG ASP A 110 −8.213 20.006 −80.348 1.00 26.78 C ATOM 807 OD1 ASP A 110 −6.974 19.920 −80.183 1.00 26.62 O ATOM 808 OD2 ASP A 110 −8.885 19.112 −80.906 1.00 27.29 O ATOM 809 C ASP A 110 −8.567 23.588 −79.012 1.00 27.84 C ATOM 810 O ASP A 110 −9.335 23.933 −78.127 1.00 27.41 O ATOM 811 N ARG A 111 −8.156 24.408 −79.978 1.00 30.03 N ATOM 812 CA ARG A 111 −8.589 25.806 −80.044 1.00 31.12 C ATOM 813 CB ARG A 111 −7.853 26.565 −81.160 1.00 31.12 C ATOM 814 C ARG A 111 −10.098 25.889 −80.242 1.00 31.49 C ATOM 815 O ARG A 111 −10.770 26.707 −79.607 1.00 32.37 O ATOM 816 N ILE A 112 −10.618 25.037 −81.123 1.00 30.32 N ATOM 817 CA ILE A 112 −12.046 24.955 −81.378 1.00 29.53 C ATOM 818 CB ILE A 112 −12.335 24.707 −82.877 1.00 29.86 C ATOM 819 C ILE A 112 −12.563 23.809 −80.534 1.00 29.06 C ATOM 820 O ILE A 112 −11.883 23.384 −79.602 1.00 29.92 O ATOM 821 N GLY A 113 −13.758 23.313 −80.844 1.00 28.44 N ATOM 822 CA GLY A 113 −14.264 22.098 −80.211 1.00 27.59 C ATOM 823 C GLY A 113 −15.298 22.316 −79.125 1.00 27.02 C ATOM 824 O GLY A 113 −15.002 22.876 −78.071 1.00 26.48 O ATOM 825 N ARG A 114 −16.522 21.873 −79.405 1.00 27.22 N ATOM 826 CA ARG A 114 −17.592 21.804 −78.416 1.00 26.30 C ATOM 827 CB ARG A 114 −18.965 21.751 −79.110 1.00 24.56 C ATOM 828 C ARG A 114 −17.378 20.538 −77.589 1.00 26.59 C ATOM 829 O ARG A 114 −17.428 19.424 −78.141 1.00 27.58 O ATOM 830 N PRO A 115 −17.117 20.694 −76.272 1.00 25.94 N ATOM 831 CA PRO A 115 −17.047 19.544 −75.371 1.00 25.63 C ATOM 832 CB PRO A 115 −17.006 20.189 −73.987 1.00 24.50 C ATOM 833 CG PRO A 115 −16.374 21.511 −74.215 1.00 24.29 C ATOM 834 CD PRO A 115 −16.873 21.961 −75.558 1.00 25.32 C ATOM 835 C PRO A 115 −18.294 18.679 −75.500 1.00 26.28 C ATOM 836 O PRO A 115 −19.405 19.204 −75.539 1.00 26.09 O ATOM 837 N SER A 116 −18.104 17.368 −75.575 1.00 28.03 N ATOM 838 CA SER A 116 −19.217 16.428 −75.719 1.00 30.71 C ATOM 839 CB SER A 116 −18.691 15.055 −76.113 1.00 30.73 C ATOM 840 OG SER A 116 −17.847 15.153 −77.246 1.00 30.70 O ATOM 841 C SER A 116 −20.087 16.313 −74.465 1.00 32.58 C ATOM 842 O SER A 116 −19.583 16.344 −73.342 1.00 33.75 O ATOM 843 N GLU A 117 −21.393 16.163 −74.676 1.00 35.42 N ATOM 844 CA GLU A 117 −22.387 16.139 −73.594 1.00 36.56 C ATOM 845 CB GLU A 117 −23.811 15.976 −74.159 1.00 39.54 C ATOM 846 CG GLU A 117 −24.151 16.870 −75.345 1.00 42.64 C ATOM 847 CD GLU A 117 −25.388 16.398 −76.094 1.00 45.62 C ATOM 848 OE1 GLU A 117 −25.231 15.703 −77.135 1.00 45.00 O ATOM 849 OE2 GLU A 117 −26.515 16.718 −75.636 1.00 47.14 O ATOM 850 C GLU A 117 −22.112 14.994 −72.645 1.00 35.37 C ATOM 851 O GLU A 117 −22.367 15.099 −71.445 1.00 37.23 O ATOM 852 N THR A 118 −21.600 13.897 −73.200 1.00 34.25 N ATOM 853 CA THR A 118 −21.293 12.692 −72.429 1.00 32.66 C ATOM 854 CB THR A 118 −21.485 11.424 −73.297 1.00 33.17 C ATOM 855 OG1 THR A 118 −22.733 10.809 −72.950 1.00 33.59 O ATOM 856 CG2 THR A 118 −20.345 10.411 −73.111 1.00 32.33 C ATOM 857 C THR A 118 −19.918 12.751 −71.733 1.00 30.72 C ATOM 858 O THR A 118 −19.463 11.776 −71.142 1.00 32.67 O ATOM 859 N GLY A 119 −19.278 13.912 −71.792 1.00 28.18 N ATOM 860 CA GLY A 119 −18.071 14.169 −71.030 1.00 24.65 C ATOM 861 C GLY A 119 −16.856 13.552 −71.664 1.00 22.55 C ATOM 862 O GLY A 119 −16.965 12.826 −72.644 1.00 22.36 O ATOM 863 N ILE A 120 −15.699 13.859 −71.088 1.00 20.92 N ATOM 864 CA ILE A 120 −14.408 13.296 −71.481 1.00 19.43 C ATOM 865 CB ILE A 120 −13.282 13.879 −70.594 1.00 18.56 C ATOM 866 CG1 ILE A 120 −13.174 15.402 −70.794 1.00 17.68 C ATOM 867 CD1 ILE A 120 −11.965 16.051 −70.162 1.00 17.00 C ATOM 868 CG2 ILE A 120 −11.968 13.158 −70.855 1.00 18.71 C ATOM 869 C ILE A 120 −14.401 11.766 −71.372 1.00 19.19 C ATOM 870 O ILE A 120 −14.990 11.209 −70.450 1.00 19.37 O ATOM 871 N ILE A 121 −13.756 11.097 −72.325 1.00 18.83 N ATOM 872 CA ILE A 121 −13.545 9.652 −72.259 1.00 18.96 C ATOM 873 CB ILE A 121 −14.552 8.885 −73.131 1.00 18.80 C ATOM 874 CG1 ILE A 121 −15.965 9.035 −72.581 1.00 19.28 C ATOM 875 CD1 ILE A 121 −17.015 8.237 −73.328 1.00 19.92 C ATOM 876 CG2 ILE A 121 −14.163 7.418 −73.226 1.00 18.73 C ATOM 877 C ILE A 121 −12.126 9.297 −72.716 1.00 19.65 C ATOM 878 O ILE A 121 −11.722 9.629 −73.838 1.00 20.25 O ATOM 879 N GLY A 122 −11.371 8.629 −71.845 1.00 19.77 N ATOM 880 CA GLY A 122 −10.027 8.182 −72.181 1.00 19.74 C ATOM 881 C GLY A 122 −10.000 6.676 −72.281 1.00 20.28 C ATOM 882 O GLY A 122 −10.538 5.992 −71.420 1.00 20.81 O ATOM 883 N ILE A 123 −9.385 6.158 −73.336 1.00 20.19 N ATOM 884 CA ILE A 123 −9.258 4.721 −73.515 1.00 20.51 C ATOM 885 CB ILE A 123 −10.386 4.137 −74.394 1.00 20.75 C ATOM 886 CG1 ILE A 123 −10.654 5.026 −75.618 1.00 20.88 C ATOM 887 CD1 ILE A 123 −11.463 4.358 −76.716 1.00 20.73 C ATOM 888 CG2 ILE A 123 −11.655 3.955 −73.580 1.00 20.64 C ATOM 889 C ILE A 123 −7.909 4.363 −74.124 1.00 21.16 C ATOM 890 O ILE A 123 −7.417 5.052 −75.022 1.00 21.17 O ATOM 891 N ILE A 124 −7.311 3.292 −73.613 1.00 21.66 N ATOM 892 CA ILE A 124 −6.063 2.761 −74.145 1.00 22.44 C ATOM 893 CB ILE A 124 −5.006 2.578 −73.036 1.00 21.59 C ATOM 894 CG1 ILE A 124 −4.737 3.907 −72.343 1.00 21.81 C ATOM 895 CD1 ILE A 124 −3.284 4.153 −71.992 1.00 22.24 C ATOM 896 CG2 ILE A 124 −3.719 1.994 −73.602 1.00 21.83 C ATOM 897 C ILE A 124 −6.358 1.411 −74.784 1.00 23.88 C ATOM 898 O ILE A 124 −7.026 0.581 −74.181 1.00 24.64 O ATOM 899 N ASP A 125 −5.874 1.182 −76.001 1.00 25.36 N ATOM 900 CA ASP A 125 −6.102 −0.108 −76.645 1.00 26.92 C ATOM 901 CB ASP A 125 −5.807 −0.034 −78.143 1.00 27.76 C ATOM 902 CG ASP A 125 −4.333 −0.133 −78.453 1.00 29.50 C ATOM 903 OD1 ASP A 125 −3.816 −1.269 −78.498 1.00 28.74 O ATOM 904 OD2 ASP A 125 −3.701 0.928 −78.677 1.00 31.63 O ATOM 905 C ASP A 125 −5.301 −1.220 −75.947 1.00 27.48 C ATOM 906 O ASP A 125 −4.364 −0.932 −75.201 1.00 26.88 O ATOM 907 N PRO A 126 −5.680 −2.490 −76.183 1.00 27.72 N ATOM 908 CA PRO A 126 −5.086 −3.637 −75.497 1.00 28.38 C ATOM 909 CB PRO A 126 −5.945 −4.814 −75.964 1.00 27.62 C ATOM 910 CG PRO A 126 −7.179 −4.207 −76.528 1.00 27.56 C ATOM 911 CD PRO A 126 −6.755 −2.901 −77.097 1.00 27.28 C ATOM 912 C PRO A 126 −3.623 −3.909 −75.847 1.00 29.52 C ATOM 913 O PRO A 126 −2.924 −4.543 −75.065 1.00 29.93 O ATOM 914 N GLU A 127 −3.172 −3.468 −77.016 1.00 32.33 N ATOM 915 CA GLU A 127 −1.782 −3.700 −77.442 1.00 35.39 C ATOM 916 CB GLU A 127 −1.704 −4.019 −78.940 1.00 38.15 C ATOM 917 CG GLU A 127 −2.187 −5.408 −79.339 1.00 43.14 C ATOM 918 CD GLU A 127 −1.930 −5.707 −80.815 1.00 49.66 C ATOM 919 OE1 GLU A 127 −2.040 −4.767 −81.653 1.00 53.44 O ATOM 920 OE2 GLU A 127 −1.614 −6.878 −81.415 1.00 50.14 O ATOM 921 C GLU A 127 −0.926 −2.482 −77.120 1.00 35.28 C ATOM 922 O GLU A 127 0.238 −2.390 −77.531 1.00 34.93 O ATOM 923 N CYS A 128 −1.529 −1.539 −76.398 1.00 34.85 N ATOM 924 CA CYS A 128 −0.870 −0.306 −75.981 1.00 33.48 C ATOM 925 CB CYS A 128 0.118 −0.586 −74.839 1.00 33.97 C ATOM 926 SG CYS A 128 −0.689 −1.172 −73.327 1.00 36.74 S ATOM 927 C CYS A 128 −0.192 0.421 −77.133 1.00 31.45 C ATOM 928 O CYS A 128 0.949 0.851 −77.009 1.00 32.11 O ATOM 929 N ARG A 129 −0.902 0.548 −78.252 1.00 29.95 N ATOM 930 CA ARG A 129 −0.423 1.340 −79.385 1.00 29.76 C ATOM 931 CB ARG A 129 −1.076 0.903 −80.700 1.00 29.41 C ATOM 932 CG ARG A 129 −0.907 −0.557 −81.071 1.00 29.77 C ATOM 933 CD ARG A 129 0.546 −0.937 −81.265 1.00 29.84 C ATOM 934 NE ARG A 129 0.697 −1.784 −82.441 1.00 30.10 N ATOM 935 CZ ARG A 129 1.353 −1.426 −83.541 1.00 30.27 C ATOM 936 NH1 ARG A 129 1.947 −0.238 −83.620 1.00 29.24 N ATOM 937 NH2 ARG A 129 1.426 −2.266 −84.564 1.00 30.92 N ATOM 938 C ARG A 129 −0.700 2.822 −79.164 1.00 29.33 C ATOM 939 O ARG A 129 0.170 3.662 −79.390 1.00 29.85 O ATOM 940 N MET A 130 −1.914 3.138 −78.720 1.00 28.46 N ATOM 941 CA MET A 130 −2.327 4.529 −78.568 1.00 27.35 C ATOM 942 CB MET A 130 −3.093 4.968 −79.815 1.00 27.89 C ATOM 943 CG MET A 130 −4.457 4.310 −79.934 1.00 28.31 C ATOM 944 SD MET A 130 −5.073 4.307 −81.616 1.00 28.28 S ATOM 945 CE MET A 130 −4.170 2.937 −82.313 1.00 27.53 C ATOM 946 C MET A 130 −3.194 4.797 −77.334 1.00 25.84 C ATOM 947 O MET A 130 −3.725 3.882 −76.715 1.00 25.49 O ATOM 948 N ILE A 131 −3.319 6.071 −76.995 1.00 24.20 N ATOM 949 CA ILE A 131 −4.423 6.552 −76.196 1.00 22.81 C ATOM 950 CB ILE A 131 −3.951 7.635 −75.212 1.00 22.74 C ATOM 951 CG1 ILE A 131 −2.924 7.055 −74.248 1.00 23.03 C ATOM 952 CD1 ILE A 131 −1.809 8.021 −73.925 1.00 23.81 C ATOM 953 CG2 ILE A 131 −5.114 8.225 −74.431 1.00 22.50 C ATOM 954 C ILE A 131 −5.429 7.145 −77.176 1.00 22.12 C ATOM 955 O ILE A 131 −5.063 7.900 −78.083 1.00 21.78 O ATOM 956 N GLY A 132 −6.693 6.782 −77.009 1.00 21.60 N ATOM 957 CA GLY A 132 −7.773 7.393 −77.781 1.00 21.48 C ATOM 958 C GLY A 132 −8.553 8.347 −76.902 1.00 21.27 C ATOM 959 O GLY A 132 −9.025 7.965 −75.838 1.00 22.28 O ATOM 960 N LEU A 133 −8.680 9.595 −77.329 1.00 20.88 N ATOM 961 CA LEU A 133 −9.356 10.600 −76.518 1.00 20.61 C ATOM 962 CB LEU A 133 −8.427 11.759 −76.179 1.00 20.41 C ATOM 963 CG LEU A 133 −7.284 11.366 −75.262 1.00 20.24 C ATOM 964 CD1 LEU A 133 −6.398 12.567 −74.993 1.00 20.01 C ATOM 965 CD2 LEU A 133 −7.841 10.780 −73.977 1.00 20.20 C ATOM 966 C LEU A 133 −10.575 11.137 −77.198 1.00 20.55 C ATOM 967 O LEU A 133 −10.502 11.625 −78.330 1.00 19.72 O ATOM 968 N ARG A 134 −11.698 11.035 −76.494 1.00 21.09 N ATOM 969 CA ARG A 134 −12.923 11.667 −76.915 1.00 21.89 C ATOM 970 CB ARG A 134 −14.091 10.691 −76.869 1.00 23.69 C ATOM 971 CG ARG A 134 −15.296 11.114 −77.708 1.00 25.41 C ATOM 972 CD ARG A 134 −15.976 12.355 −77.149 1.00 26.47 C ATOM 973 NE ARG A 134 −17.392 12.123 −76.905 1.00 27.92 N ATOM 974 CZ ARG A 134 −17.894 11.777 −75.723 1.00 30.38 C ATOM 975 NH1 ARG A 134 −17.094 11.615 −74.674 1.00 30.51 N ATOM 976 NH2 ARG A 134 −19.201 11.597 −75.586 1.00 32.62 N ATOM 977 C ARG A 134 −13.184 12.845 −76.015 1.00 21.60 C ATOM 978 O ARG A 134 −13.527 12.681 −74.844 1.00 21.54 O ATOM 979 N LEU A 135 −13.003 14.034 −76.584 1.00 21.32 N ATOM 980 CA LEU A 135 −13.128 15.288 −75.869 1.00 20.71 C ATOM 981 CB LEU A 135 −11.825 16.066 −75.971 1.00 19.99 C ATOM 982 CG LEU A 135 −10.560 15.308 −75.562 1.00 20.28 C ATOM 983 CD1 LEU A 135 −9.317 16.112 −75.915 1.00 20.04 C ATOM 984 CD2 LEU A 135 −10.575 14.953 −74.074 1.00 20.31 C ATOM 985 C LEU A 135 −14.259 16.099 −76.476 1.00 21.43 C ATOM 986 O LEU A 135 −15.066 16.695 −75.767 1.00 22.14 O ATOM 987 N TYR A 136 −14.329 16.102 −77.801 1.00 21.72 N ATOM 988 CA TYR A 136 −15.289 16.930 −78.500 1.00 21.20 C ATOM 989 CB TYR A 136 −14.550 18.038 −79.237 1.00 21.07 C ATOM 990 CG TYR A 136 −13.502 18.716 −78.379 1.00 21.35 C ATOM 991 CD1 TYR A 136 −13.865 19.403 −77.219 1.00 21.43 C ATOM 992 CE1 TYR A 136 −12.912 20.022 −76.422 1.00 21.19 C ATOM 993 CZ TYR A 136 −11.579 19.963 −76.774 1.00 20.99 C ATOM 994 OH TYR A 136 −10.656 20.603 −75.979 1.00 20.83 O ATOM 995 CE2 TYR A 136 −11.189 19.286 −77.920 1.00 21.12 C ATOM 996 CD2 TYR A 136 −12.149 18.671 −78.719 1.00 21.14 C ATOM 997 C TYR A 136 −16.188 16.140 −79.453 1.00 21.43 C ATOM 998 O TYR A 136 −15.866 15.019 −79.890 1.00 20.95 O ATOM 999 N ASP A 137 −17.336 16.725 −79.754 1.00 21.13 N ATOM 1000 CA ASP A 137 −18.197 16.179 −80.769 1.00 21.20 C ATOM 1001 CB ASP A 137 −19.501 16.969 −80.812 1.00 21.95 C ATOM 1002 CG ASP A 137 −20.231 16.967 −79.465 1.00 22.94 C ATOM 1003 OD1 ASP A 137 −20.256 15.911 −78.791 1.00 23.17 O ATOM 1004 OD2 ASP A 137 −20.785 18.021 −79.077 1.00 23.77 O ATOM 1005 C ASP A 137 −17.459 16.225 −82.105 1.00 20.61 C ATOM 1006 O ASP A 137 −16.637 17.102 −82.331 1.00 20.24 O ATOM 1007 N GLY A 138 −17.712 15.243 −82.963 1.00 20.88 N ATOM 1008 CA GLY A 138 −17.093 15.197 −84.288 1.00 20.27 C ATOM 1009 C GLY A 138 −15.692 14.612 −84.372 1.00 20.22 C ATOM 1010 O GLY A 138 −15.341 14.030 −85.384 1.00 20.94 O ATOM 1011 N LEU A 139 −14.881 14.766 −83.327 1.00 19.84 N ATOM 1012 CA LEU A 139 −13.475 14.338 −83.397 1.00 19.79 C ATOM 1013 CB LEU A 139 −12.535 15.537 −83.210 1.00 19.30 C ATOM 1014 CG LEU A 139 −12.736 16.760 −84.100 1.00 18.95 C ATOM 1015 CD1 LEU A 139 −12.450 18.035 −83.329 1.00 18.75 C ATOM 1016 CD2 LEU A 139 −11.872 16.674 −85.343 1.00 19.12 C ATOM 1017 C LEU A 139 −13.096 13.219 −82.417 1.00 20.06 C ATOM 1018 O LEU A 139 −13.684 13.095 −81.351 1.00 21.08 O ATOM 1019 N PHE A 140 −12.099 12.423 −82.790 1.00 19.98 N ATOM 1020 CA PHE A 140 −11.536 11.401 −81.922 1.00 20.61 C ATOM 1021 CB PHE A 140 −11.926 10.006 −82.431 1.00 20.82 C ATOM 1022 CG PHE A 140 −11.423 8.860 −81.574 1.00 21.15 C ATOM 1023 CD1 PHE A 140 −12.103 8.478 −80.410 1.00 21.07 C ATOM 1024 CE1 PHE A 140 −11.651 7.415 −79.632 1.00 21.03 C ATOM 1025 CZ PHE A 140 −10.520 6.704 −80.015 1.00 20.94 C ATOM 1026 CE2 PHE A 140 −9.842 7.059 −81.176 1.00 21.25 C ATOM 1027 CD2 PHE A 140 −10.297 8.125 −81.954 1.00 21.15 C ATOM 1028 C PHE A 140 −10.022 11.595 −81.935 1.00 21.36 C ATOM 1029 O PHE A 140 −9.378 11.408 −82.971 1.00 21.91 O ATOM 1030 N LYS A 141 −9.456 12.004 −80.797 1.00 21.63 N ATOM 1031 CA LYS A 141 −8.014 12.298 −80.723 1.00 21.27 C ATOM 1032 CB LYS A 141 −7.701 13.369 −79.663 1.00 20.64 C ATOM 1033 CG LYS A 141 −6.255 13.874 −79.689 1.00 19.81 C ATOM 1034 CD LYS A 141 −6.076 15.179 −78.934 1.00 19.04 C ATOM 1035 CE LYS A 141 −7.061 16.225 −79.421 1.00 18.83 C ATOM 1036 NZ LYS A 141 −6.577 17.602 −79.173 1.00 18.95 N ATOM 1037 C LYS A 141 −7.207 11.031 −80.456 1.00 21.39 C ATOM 1038 O LYS A 141 −7.629 10.164 −79.684 1.00 22.05 O ATOM 1039 N VAL A 142 −6.047 10.929 −81.098 1.00 20.50 N ATOM 1040 CA VAL A 142 −5.207 9.763 −80.950 1.00 19.90 C ATOM 1041 CB VAL A 142 −5.192 8.912 −82.250 1.00 19.53 C ATOM 1042 CG1 VAL A 142 −3.939 8.065 −82.336 1.00 19.39 C ATOM 1043 CG2 VAL A 142 −6.431 8.025 −82.338 1.00 19.31 C ATOM 1044 C VAL A 142 −3.808 10.201 −80.567 1.00 19.77 C ATOM 1045 O VAL A 142 −3.183 10.985 −81.271 1.00 19.50 O ATOM 1046 N ILE A 143 −3.338 9.713 −79.425 1.00 20.16 N ATOM 1047 CA ILE A 143 −1.922 9.829 −79.065 1.00 20.71 C ATOM 1048 CB ILE A 143 −1.713 10.311 −77.611 1.00 20.37 C ATOM 1049 CG1 ILE A 143 −2.371 11.669 −77.388 1.00 20.26 C ATOM 1050 CD1 ILE A 143 −2.994 11.808 −76.017 1.00 20.84 C ATOM 1051 CG2 ILE A 143 −0.230 10.361 −77.269 1.00 19.82 C ATOM 1052 C ILE A 143 −1.212 8.477 −79.254 1.00 21.29 C ATOM 1053 O ILE A 143 −1.480 7.504 −78.524 1.00 21.06 O ATOM 1054 N PRO A 144 −0.312 8.408 −80.248 1.00 21.45 N ATOM 1055 CA PRO A 144 0.581 7.262 −80.351 1.00 21.51 C ATOM 1056 CB PRO A 144 1.389 7.558 −81.619 1.00 21.19 C ATOM 1057 CG PRO A 144 1.149 9.005 −81.921 1.00 20.88 C ATOM 1058 CD PRO A 144 −0.222 9.286 −81.426 1.00 20.81 C ATOM 1059 C PRO A 144 1.502 7.139 −79.133 1.00 21.84 C ATOM 1060 O PRO A 144 2.091 8.121 −78.688 1.00 21.41 O ATOM 1061 N LEU A 145 1.575 5.937 −78.581 1.00 23.09 N ATOM 1062 CA LEU A 145 2.541 5.613 −77.553 1.00 24.87 C ATOM 1063 CB LEU A 145 1.939 4.598 −76.578 1.00 24.50 C ATOM 1064 CG LEU A 145 0.677 5.031 −75.820 1.00 24.70 C ATOM 1065 CD1 LEU A 145 −0.043 3.840 −75.196 1.00 24.36 C ATOM 1066 CD2 LEU A 145 1.005 6.079 −74.764 1.00 23.92 C ATOM 1067 C LEU A 145 3.779 5.036 −78.243 1.00 27.01 C ATOM 1068 O LEU A 145 3.788 3.866 −78.636 1.00 28.30 O ATOM 1069 N ASP A 146 4.814 5.853 −78.421 1.00 28.58 N ATOM 1070 CA ASP A 146 5.942 5.440 −79.259 1.00 30.41 C ATOM 1071 CB ASP A 146 5.989 6.253 −80.565 1.00 30.94 C ATOM 1072 CG ASP A 146 5.371 5.506 −81.746 1.00 30.83 C ATOM 1073 OD1 ASP A 146 5.197 4.271 −81.661 1.00 31.21 O ATOM 1074 OD2 ASP A 146 5.068 6.155 −82.767 1.00 30.98 O ATOM 1075 C ASP A 146 7.306 5.433 −78.568 1.00 31.83 C ATOM 1076 O ASP A 146 8.255 4.802 −79.058 1.00 32.96 O ATOM 1077 N ARG A 147 7.392 6.111 −77.427 1.00 31.33 N ATOM 1078 CA ARG A 147 8.648 6.264 −76.679 1.00 31.32 C ATOM 1079 CB ARG A 147 9.629 5.088 −76.893 1.00 29.74 C ATOM 1080 C ARG A 147 9.271 7.573 −77.096 1.00 31.10 C ATOM 1081 O ARG A 147 9.675 8.373 −76.247 1.00 32.96 O ATOM 1082 N ASP A 148 9.331 7.799 −78.405 1.00 30.18 N ATOM 1083 CA ASP A 148 9.811 9.064 −78.940 1.00 29.15 C ATOM 1084 CB ASP A 148 10.421 8.872 −80.336 1.00 28.53 C ATOM 1085 C ASP A 148 8.707 10.136 −78.951 1.00 28.46 C ATOM 1086 O ASP A 148 8.907 11.209 −79.502 1.00 29.93 O ATOM 1087 N ASN A 149 7.555 9.847 −78.333 1.00 26.72 N ATOM 1088 CA ASN A 149 6.480 10.838 −78.180 1.00 24.78 C ATOM 1089 CB ASN A 149 5.129 10.265 −78.642 1.00 24.37 C ATOM 1090 CG ASN A 149 4.089 11.350 −78.928 1.00 24.34 C ATOM 1091 OD1 ASN A 149 4.390 12.550 −78.901 1.00 24.24 O ATOM 1092 ND2 ASN A 149 2.860 10.929 −79.219 1.00 23.72 N ATOM 1093 C ASN A 149 6.381 11.384 −76.747 1.00 24.38 C ATOM 1094 O ASN A 149 5.311 11.343 −76.115 1.00 24.38 O ATOM 1095 N LYS A 150 7.500 11.909 −76.248 1.00 23.61 N ATOM 1096 CA LYS A 150 7.567 12.504 −74.912 1.00 23.02 C ATOM 1097 CB LYS A 150 9.016 12.852 −74.551 1.00 22.42 C ATOM 1098 C LYS A 150 6.643 13.726 −74.735 1.00 23.09 C ATOM 1099 O LYS A 150 6.172 13.992 −73.638 1.00 23.48 O ATOM 1100 N GLU A 151 6.371 14.457 −75.810 1.00 23.37 N ATOM 1101 CA GLU A 151 5.451 15.598 −75.730 1.00 23.90 C ATOM 1102 CB GLU A 151 5.943 16.734 −76.607 1.00 25.04 C ATOM 1103 CG GLU A 151 7.180 17.436 −76.083 1.00 26.49 C ATOM 1104 CD GLU A 151 7.803 18.330 −77.132 1.00 26.97 C ATOM 1105 OE1 GLU A 151 7.247 18.390 −78.250 1.00 27.05 O ATOM 1106 OE2 GLU A 151 8.843 18.963 −76.845 1.00 27.40 O ATOM 1107 C GLU A 151 3.976 15.281 −76.065 1.00 23.62 C ATOM 1108 O GLU A 151 3.170 16.200 −76.281 1.00 22.96 O ATOM 1109 N LEU A 152 3.632 13.990 −76.092 1.00 22.95 N ATOM 1110 CA LEU A 152 2.268 13.520 −76.401 1.00 22.39 C ATOM 1111 CB LEU A 152 1.394 13.507 −75.148 1.00 22.22 C ATOM 1112 CG LEU A 152 1.905 12.665 −73.984 1.00 22.59 C ATOM 1113 CD1 LEU A 152 1.112 13.012 −72.739 1.00 22.49 C ATOM 1114 CD2 LEU A 152 1.835 11.172 −74.279 1.00 21.91 C ATOM 1115 C LEU A 152 1.545 14.270 −77.521 1.00 22.03 C ATOM 1116 O LEU A 152 0.338 14.485 −77.441 1.00 21.60 O ATOM 1117 N LYS A 153 2.290 14.661 −78.558 1.00 22.04 N ATOM 1118 CA LYS A 153 1.702 15.215 −79.786 1.00 21.22 C ATOM 1119 CB LYS A 153 2.799 15.626 −80.787 1.00 20.44 C ATOM 1120 C LYS A 153 0.743 14.170 −80.382 1.00 20.59 C ATOM 1121 O LYS A 153 0.941 12.954 −80.201 1.00 20.13 O ATOM 1122 N ALA A 154 −0.303 14.642 −81.062 1.00 19.71 N ATOM 1123 CA ALA A 154 −1.429 13.777 −81.408 1.00 19.13 C ATOM 1124 CB ALA A 154 −2.411 13.712 −80.235 1.00 19.68 C ATOM 1125 C ALA A 154 −2.146 14.220 −82.666 1.00 18.42 C ATOM 1126 O ALA A 154 −1.872 15.279 −83.191 1.00 18.07 O ATOM 1127 N PHE A 155 −3.082 13.398 −83.133 1.00 18.67 N ATOM 1128 CA PHE A 155 −3.911 13.749 −84.282 1.00 19.14 C ATOM 1129 CB PHE A 155 −3.357 13.154 −85.579 1.00 19.07 C ATOM 1130 CG PHE A 155 −3.241 11.656 −85.571 1.00 18.85 C ATOM 1131 CD1 PHE A 155 −4.347 10.853 −85.844 1.00 18.79 C ATOM 1132 CE1 PHE A 155 −4.235 9.472 −85.857 1.00 18.70 C ATOM 1133 CZ PHE A 155 −3.010 8.880 −85.598 1.00 18.75 C ATOM 1134 CE2 PHE A 155 −1.900 9.667 −85.329 1.00 18.66 C ATOM 1135 CD2 PHE A 155 −2.013 11.045 −85.330 1.00 18.67 C ATOM 1136 C PHE A 155 −5.364 13.351 −84.097 1.00 19.79 C ATOM 1137 O PHE A 155 −5.663 12.368 −83.408 1.00 19.82 O ATOM 1138 N ASN A 156 −6.254 14.126 −84.728 1.00 20.50 N ATOM 1139 CA ASN A 156 −7.702 13.918 −84.651 1.00 20.81 C ATOM 1140 CB ASN A 156 −8.416 15.261 −84.601 1.00 21.24 C ATOM 1141 CG ASN A 156 −8.175 16.007 −83.313 1.00 21.30 C ATOM 1142 OD1 ASN A 156 −7.463 17.005 −83.304 1.00 20.95 O ATOM 1143 ND2 ASN A 156 −8.783 15.538 −82.216 1.00 21.75 N ATOM 1144 C ASN A 156 −8.239 13.160 −85.845 1.00 20.58 C ATOM 1145 O ASN A 156 −7.705 13.282 −86.931 1.00 21.05 O ATOM 1146 N ILE A 157 −9.314 12.404 −85.643 1.00 20.79 N ATOM 1147 CA ILE A 157 −10.038 11.755 −86.740 1.00 21.13 C ATOM 1148 CB ILE A 157 −9.974 10.214 −86.645 1.00 21.13 C ATOM 1149 CG1 ILE A 157 −8.531 9.741 −86.396 1.00 21.40 C ATOM 1150 CD1 ILE A 157 −8.387 8.253 −86.120 1.00 21.25 C ATOM 1151 CG2 ILE A 157 −10.545 9.588 −87.909 1.00 21.33 C ATOM 1152 C ILE A 157 −11.503 12.196 −86.731 1.00 21.47 C ATOM 1153 O ILE A 157 −12.136 12.207 −85.689 1.00 21.83 O ATOM 1154 N ARG A 158 −12.040 12.565 −87.889 1.00 22.28 N ATOM 1155 CA ARG A 158 −13.436 12.993 −87.969 1.00 23.01 C ATOM 1156 CB ARG A 158 −13.742 13.648 −89.326 1.00 22.33 C ATOM 1157 C ARG A 158 −14.387 11.824 −87.689 1.00 23.89 C ATOM 1158 O ARG A 158 −14.168 10.698 −88.138 1.00 23.82 O ATOM 1159 N LEU A 159 −15.417 12.100 −86.901 1.00 25.68 N ATOM 1160 CA LEU A 159 −16.498 11.154 −86.666 1.00 27.15 C ATOM 1161 CB LEU A 159 −16.728 10.926 −85.163 1.00 26.45 C ATOM 1162 CG LEU A 159 −15.675 10.080 −84.450 1.00 26.50 C ATOM 1163 CD1 LEU A 159 −16.187 9.550 −83.124 1.00 25.90 C ATOM 1164 CD2 LEU A 159 −15.276 8.929 −85.348 1.00 26.75 C ATOM 1165 C LEU A 159 −17.762 11.689 −87.291 1.00 28.46 C ATOM 1166 O LEU A 159 −18.191 12.797 −86.979 1.00 28.72 O ATOM 1167 N GLU A 160 −18.351 10.904 −88.183 1.00 30.46 N ATOM 1168 CA GLU A 160 −19.672 11.216 −88.697 1.00 32.15 C ATOM 1169 CB GLU A 160 −20.118 10.144 −89.691 1.00 35.24 C ATOM 1170 CG GLU A 160 −19.556 10.321 −91.090 1.00 38.16 C ATOM 1171 CD GLU A 160 −20.514 11.058 −92.012 1.00 43.43 C ATOM 1172 OE1 GLU A 160 −21.706 11.204 −91.649 1.00 45.95 O ATOM 1173 OE2 GLU A 160 −20.086 11.479 −93.114 1.00 46.22 O ATOM 1174 C GLU A 160 −20.666 11.357 −87.531 1.00 31.20 C ATOM 1175 O GLU A 160 −21.436 12.318 −87.476 1.00 32.34 O ATOM 1176 N GLU A 161 −20.606 10.427 −86.584 1.00 29.59 N ATOM 1177 CA GLU A 161 −21.498 10.427 −85.428 1.00 28.98 C ATOM 1178 CB GLU A 161 −21.559 9.029 −84.813 1.00 29.63 C ATOM 1179 CG GLU A 161 −22.089 7.956 −85.755 1.00 30.27 C ATOM 1180 CD GLU A 161 −21.113 7.560 −86.859 1.00 32.69 C ATOM 1181 OE1 GLU A 161 −19.929 7.970 −86.814 1.00 33.66 O ATOM 1182 OE2 GLU A 161 −21.533 6.823 −87.783 1.00 33.80 O ATOM 1183 C GLU A 161 −21.081 11.466 −84.385 1.00 27.52 C ATOM 1184 O GLU A 161 −19.954 11.460 −83.905 1.00 27.08 O ATOM 1185 N LEU A 162 −22.008 12.356 −84.047 1.00 27.25 N ATOM 1186 CA LEU A 162 −21.720 13.525 −83.211 1.00 27.63 C ATOM 1187 CB LEU A 162 −22.414 14.758 −83.779 1.00 26.35 C ATOM 1188 CG LEU A 162 −21.789 15.361 −85.034 1.00 25.70 C ATOM 1189 CD1 LEU A 162 −22.857 16.039 −85.873 1.00 25.47 C ATOM 1190 CD2 LEU A 162 −20.681 16.339 −84.680 1.00 25.35 C ATOM 1191 C LEU A 162 −22.121 13.357 −81.748 1.00 28.97 C ATOM 1192 O LEU A 162 −21.598 14.051 −80.875 1.00 29.65 O ATOM 1193 N HIS A 163 −23.060 12.447 −81.489 1.00 29.80 N ATOM 1194 CA HIS A 163 −23.501 12.154 −80.130 1.00 28.90 C ATOM 1195 CB HIS A 163 −25.007 12.377 −79.976 1.00 31.33 C ATOM 1196 CG HIS A 163 −25.538 13.534 −80.797 1.00 35.52 C ATOM 1197 ND1 HIS A 163 −25.051 14.794 −80.684 1.00 37.41 N ATOM 1198 CE1 HIS A 163 −25.701 15.604 −81.546 1.00 36.70 C ATOM 1199 NE2 HIS A 163 −26.607 14.863 −82.213 1.00 36.79 N ATOM 1200 CD2 HIS A 163 −26.535 13.584 −81.776 1.00 35.98 C ATOM 1201 C HIS A 163 −23.117 10.756 −79.762 1.00 27.12 C ATOM 1202 O HIS A 163 −23.924 9.832 −79.834 1.00 26.20 O ATOM 1203 N VAL A 164 −21.862 10.585 −79.375 1.00 25.78 N ATOM 1204 CA VAL A 164 −21.406 9.298 −78.869 1.00 25.97 C ATOM 1205 CB VAL A 164 −19.923 9.029 −79.218 1.00 25.34 C ATOM 1206 CG1 VAL A 164 −19.425 7.783 −78.504 1.00 24.90 C ATOM 1207 CG2 VAL A 164 −19.742 8.890 −80.728 1.00 23.72 C ATOM 1208 C VAL A 164 −21.646 9.195 −77.358 1.00 25.79 C ATOM 1209 O VAL A 164 −21.224 10.062 −76.593 1.00 26.38 O ATOM 1210 N ILE A 165 −22.345 8.139 −76.950 1.00 25.75 N ATOM 1211 CA ILE A 165 −22.632 7.871 −75.541 1.00 26.20 C ATOM 1212 CB ILE A 165 −23.836 6.921 −75.380 1.00 26.83 C ATOM 1213 CG1 ILE A 165 −24.974 7.289 −76.348 1.00 27.34 C ATOM 1214 CD1 ILE A 165 −25.973 8.277 −75.791 1.00 28.90 C ATOM 1215 CG2 ILE A 165 −24.285 6.854 −73.924 1.00 26.01 C ATOM 1216 C ILE A 165 −21.435 7.242 −74.819 1.00 26.30 C ATOM 1217 O ILE A 165 −21.112 7.630 −73.699 1.00 27.54 O ATOM 1218 N ASP A 166 −20.790 6.263 −75.445 1.00 26.10 N ATOM 1219 CA ASP A 166 −19.677 5.570 −74.806 1.00 26.58 C ATOM 1220 CB ASP A 166 −20.231 4.610 −73.749 1.00 28.65 C ATOM 1221 CG ASP A 166 −19.158 4.052 −72.829 1.00 29.92 C ATOM 1222 OD1 ASP A 166 −18.046 4.651 −72.750 1.00 30.77 O ATOM 1223 OD2 ASP A 166 −19.439 3.004 −72.192 1.00 29.65 O ATOM 1224 C ASP A 166 −18.780 4.824 −75.812 1.00 26.18 C ATOM 1225 O ASP A 166 −19.268 4.298 −76.811 1.00 26.45 O ATOM 1226 N VAL A 167 −17.477 4.768 −75.535 1.00 24.94 N ATOM 1227 CA VAL A 167 −16.518 4.128 −76.448 1.00 23.88 C ATOM 1228 CB VAL A 167 −15.891 5.161 −77.405 1.00 23.79 C ATOM 1229 CG1 VAL A 167 −15.296 6.329 −76.623 1.00 23.13 C ATOM 1230 CG2 VAL A 167 −14.857 4.493 −78.314 1.00 23.21 C ATOM 1231 C VAL A 167 −15.394 3.324 −75.762 1.00 23.51 C ATOM 1232 O VAL A 167 −14.845 3.746 −74.733 1.00 23.65 O ATOM 1233 N LYS A 168 −15.050 2.183 −76.370 1.00 22.37 N ATOM 1234 CA LYS A 168 −14.023 1.270 −75.875 1.00 21.50 C ATOM 1235 CB LYS A 168 −14.676 0.115 −75.117 1.00 20.74 C ATOM 1236 CG LYS A 168 −14.195 −0.052 −73.690 1.00 20.70 C ATOM 1237 CD LYS A 168 −15.163 0.619 −72.733 1.00 20.65 C ATOM 1238 CE LYS A 168 −14.454 1.475 −71.703 1.00 20.92 C ATOM 1239 NZ LYS A 168 −15.309 1.671 −70.497 1.00 21.35 N ATOM 1240 C LYS A 168 −13.314 0.687 −77.074 1.00 21.94 C ATOM 1241 O LYS A 168 −13.923 0.546 −78.134 1.00 23.69 O ATOM 1242 N PHE A 169 −12.038 0.340 −76.922 1.00 21.89 N ATOM 1243 CA PHE A 169 −11.341 −0.523 −77.891 1.00 21.42 C ATOM 1244 CB PHE A 169 −9.835 −0.389 −77.740 1.00 20.91 C ATOM 1245 CG PHE A 169 −9.288 0.914 −78.213 1.00 21.29 C ATOM 1246 CD1 PHE A 169 −9.129 1.164 −79.575 1.00 21.40 C ATOM 1247 CE1 PHE A 169 −8.593 2.368 −80.014 1.00 21.62 C ATOM 1248 CZ PHE A 169 −8.204 3.333 −79.091 1.00 21.43 C ATOM 1249 CE2 PHE A 169 −8.346 3.088 −77.732 1.00 21.34 C ATOM 1250 CD2 PHE A 169 −8.886 1.887 −77.299 1.00 21.57 C ATOM 1251 C PHE A 169 −11.712 −1.986 −77.648 1.00 21.87 C ATOM 1252 O PHE A 169 −11.936 −2.385 −76.506 1.00 23.56 O ATOM 1253 N LEU A 170 −11.754 −2.795 −78.696 1.00 21.49 N ATOM 1254 CA LEU A 170 −12.044 −4.216 −78.515 1.00 21.60 C ATOM 1255 CB LEU A 170 −12.935 −4.730 −79.637 1.00 21.28 C ATOM 1256 CG LEU A 170 −14.284 −4.040 −79.802 1.00 21.30 C ATOM 1257 CD1 LEU A 170 −14.875 −4.430 −81.144 1.00 21.61 C ATOM 1258 CD2 LEU A 170 −15.230 −4.389 −78.661 1.00 20.93 C ATOM 1259 C LEU A 170 −10.778 −5.052 −78.441 1.00 22.19 C ATOM 1260 O LEU A 170 −9.700 −4.596 −78.824 1.00 22.62 O ATOM 1261 N TYR A 171 −10.917 −6.279 −77.946 1.00 22.88 N ATOM 1262 CA TYR A 171 −9.821 −7.242 −77.945 1.00 23.91 C ATOM 1263 CB TYR A 171 −9.836 −8.098 −76.679 1.00 22.49 C ATOM 1264 CG TYR A 171 −9.645 −7.356 −75.384 1.00 21.77 C ATOM 1265 CD2 TYR A 171 −8.382 −7.194 −74.833 1.00 21.30 C ATOM 1266 CE2 TYR A 171 −8.209 −6.535 −73.633 1.00 20.92 C ATOM 1267 CZ TYR A 171 −9.314 −6.038 −72.964 1.00 20.91 C ATOM 1268 OH TYR A 171 −9.164 −5.381 −71.774 1.00 20.93 O ATOM 1269 CE1 TYR A 171 −10.577 −6.196 −73.482 1.00 21.16 C ATOM 1270 CD1 TYR A 171 −10.738 −6.852 −74.684 1.00 21.79 C ATOM 1271 C TYR A 171 −9.915 −8.173 −79.149 1.00 25.86 C ATOM 1272 O TYR A 171 −10.998 −8.397 −79.701 1.00 25.36 O ATOM 1273 N GLY A 172 −8.768 −8.728 −79.537 1.00 28.47 N ATOM 1274 CA GLY A 172 −8.718 −9.801 −80.530 1.00 30.12 C ATOM 1275 C GLY A 172 −9.069 −9.361 −81.934 1.00 30.35 C ATOM 1276 O GLY A 172 −9.875 −10.000 −82.610 1.00 29.19 O ATOM 1277 N CYS A 173 −8.454 −8.268 −82.373 1.00 32.15 N ATOM 1278 CA CYS A 173 −8.713 −7.724 −83.703 1.00 33.31 C ATOM 1279 CB CYS A 173 −9.333 −6.329 −83.600 1.00 32.29 C ATOM 1280 SG CYS A 173 −11.009 −6.360 −82.933 1.00 31.25 S ATOM 1281 C CYS A 173 −7.440 −7.677 −84.522 1.00 34.11 C ATOM 1282 O CYS A 173 −6.331 −7.664 −83.961 1.00 34.68 O ATOM 1283 N GLN A 174 −7.597 −7.648 −85.846 1.00 32.89 N ATOM 1284 CA GLN A 174 −6.444 −7.548 −86.733 1.00 32.00 C ATOM 1285 CB GLN A 174 −6.803 −8.059 −88.128 1.00 32.72 C ATOM 1286 C GLN A 174 −5.851 −6.116 −86.771 1.00 31.11 C ATOM 1287 O GLN A 174 −4.802 −5.885 −87.378 1.00 31.59 O ATOM 1288 N ALA A 175 −6.527 −5.173 −86.109 1.00 29.24 N ATOM 1289 CA ALA A 175 −6.038 −3.797 −85.934 1.00 27.27 C ATOM 1290 CB ALA A 175 −6.322 −2.966 −87.177 1.00 27.07 C ATOM 1291 C ALA A 175 −6.737 −3.178 −84.730 1.00 26.41 C ATOM 1292 O ALA A 175 −7.799 −3.670 −84.318 1.00 26.11 O ATOM 1293 N PRO A 176 −6.152 −2.102 −84.150 1.00 25.35 N ATOM 1294 CA PRO A 176 −6.882 −1.357 −83.118 1.00 24.40 C ATOM 1295 CB PRO A 176 −6.013 −0.124 −82.909 1.00 23.94 C ATOM 1296 CG PRO A 176 −4.634 −0.641 −83.133 1.00 24.18 C ATOM 1297 CD PRO A 176 −4.740 −1.680 −84.221 1.00 24.68 C ATOM 1298 C PRO A 176 −8.286 −0.984 −83.581 1.00 23.51 C ATOM 1299 O PRO A 176 −8.471 −0.495 −84.690 1.00 22.92 O ATOM 1300 N THR A 177 −9.266 −1.244 −82.729 1.00 23.65 N ATOM 1301 CA THR A 177 −10.664 −1.188 −83.131 1.00 23.59 C ATOM 1302 CB THR A 177 −11.179 −2.610 −83.430 1.00 22.91 C ATOM 1303 OG1 THR A 177 −10.374 −3.202 −84.452 1.00 22.69 O ATOM 1304 CG2 THR A 177 −12.621 −2.591 −83.874 1.00 22.98 C ATOM 1305 C THR A 177 −11.518 −0.575 −82.027 1.00 23.68 C ATOM 1306 O THR A 177 −11.515 −1.073 −80.899 1.00 25.01 O ATOM 1307 N ILE A 178 −12.248 0.496 −82.336 1.00 22.71 N ATOM 1308 CA ILE A 178 −13.168 1.066 −81.350 1.00 22.05 C ATOM 1309 CB ILE A 178 −13.116 2.606 −81.291 1.00 21.61 C ATOM 1310 CG1 ILE A 178 −13.648 3.242 −82.579 1.00 21.50 C ATOM 1311 CD1 ILE A 178 −13.941 4.726 −82.447 1.00 21.18 C ATOM 1312 CG2 ILE A 178 −11.707 3.079 −80.983 1.00 21.50 C ATOM 1313 C ILE A 178 −14.604 0.592 −81.540 1.00 22.74 C ATOM 1314 O ILE A 178 −15.077 0.432 −82.675 1.00 23.39 O ATOM 1315 N CYS A 179 −15.272 0.333 −80.416 1.00 22.61 N ATOM 1316 CA CYS A 179 −16.682 −0.031 −80.396 1.00 22.65 C ATOM 1317 CB CYS A 179 −16.863 −1.407 −79.791 1.00 22.78 C ATOM 1318 SG CYS A 179 −18.600 −1.853 −79.608 1.00 24.39 S ATOM 1319 C CYS A 179 −17.419 0.971 −79.542 1.00 22.86 C ATOM 1320 O CYS A 179 −17.073 1.166 −78.385 1.00 24.43 O ATOM 1321 N PHE A 180 −18.438 1.610 −80.096 1.00 22.45 N ATOM 1322 CA PHE A 180 −19.084 2.719 −79.405 1.00 22.06 C ATOM 1323 CB PHE A 180 −18.450 4.051 −79.829 1.00 22.28 C ATOM 1324 CG PHE A 180 −18.701 4.411 −81.265 1.00 22.90 C ATOM 1325 CD1 PHE A 180 −17.936 3.857 −82.279 1.00 23.73 C ATOM 1326 CE1 PHE A 180 −18.188 4.164 −83.607 1.00 24.56 C ATOM 1327 CZ PHE A 180 −19.204 5.042 −83.929 1.00 24.67 C ATOM 1328 CE2 PHE A 180 −19.972 5.598 −82.924 1.00 23.90 C ATOM 1329 CD2 PHE A 180 −19.719 5.281 −81.605 1.00 23.21 C ATOM 1330 C PHE A 180 −20.590 2.749 −79.642 1.00 22.13 C ATOM 1331 O PHE A 180 −21.079 2.354 −80.704 1.00 22.59 O ATOM 1332 N VAL A 181 −21.321 3.216 −78.638 1.00 22.10 N ATOM 1333 CA VAL A 181 −22.749 3.493 −78.775 1.00 21.84 C ATOM 1334 CB VAL A 181 −23.534 3.069 −77.513 1.00 22.00 C ATOM 1335 CG1 VAL A 181 −24.923 3.694 −77.483 1.00 21.70 C ATOM 1336 CG2 VAL A 181 −23.620 1.552 −77.446 1.00 22.25 C ATOM 1337 C VAL A 181 −22.943 4.979 −79.081 1.00 21.27 C ATOM 1338 O VAL A 181 −22.283 5.838 −78.501 1.00 21.14 O ATOM 1339 N TYR A 182 −23.825 5.262 −80.028 1.00 21.01 N ATOM 1340 CA TYR A 182 −24.100 6.618 −80.458 1.00 20.46 C ATOM 1341 CB TYR A 182 −23.277 −6.960 −81.706 1.00 19.68 C ATOM 1342 CG TYR A 182 −23.793 6.325 −82.988 1.00 19.34 C ATOM 1343 CD1 TYR A 182 −23.398 5.033 −83.365 1.00 18.95 C ATOM 1344 CE1 TYR A 182 −23.893 4.453 −84.529 1.00 18.72 C ATOM 1345 CZ TYR A 182 −24.790 5.169 −85.334 1.00 18.16 C ATOM 1346 OH TYR A 182 −25.283 4.608 −86.482 1.00 17.33 O ATOM 1347 CE2 TYR A 182 −25.191 6.443 −84.979 1.00 18.11 C ATOM 1348 CD2 TYR A 182 −24.696 7.015 −83.819 1.00 18.71 C ATOM 1349 C TYR A 182 −25.591 6.725 −80.745 1.00 20.92 C ATOM 1350 O TYR A 182 −26.273 5.707 −80.932 1.00 20.38 O ATOM 1351 N GLN A 183 −26.092 7.955 −80.765 1.00 22.25 N ATOM 1352 CA GLN A 183 −27.485 8.214 −81.089 1.00 23.44 C ATOM 1353 CB GLN A 183 −28.243 8.694 −79.863 1.00 23.57 C ATOM 1354 CG GLN A 183 −29.746 8.699 −80.071 1.00 24.41 C ATOM 1355 CD GLN A 183 −30.487 9.174 −78.857 1.00 25.18 C ATOM 1356 OE1 GLN A 183 −30.276 10.288 −78.395 1.00 26.29 O ATOM 1357 NE2 GLN A 183 −31.357 8.329 −78.320 1.00 25.99 N ATOM 1358 C GLN A 183 −27.640 9.235 −82.210 1.00 24.62 C ATOM 1359 O GLN A 183 −26.882 10.217 −82.287 1.00 24.31 O ATOM 1360 N ASP A 184 −28.625 8.983 −83.075 1.00 25.56 N ATOM 1361 CA ASP A 184 −29.054 9.941 −84.089 1.00 26.67 C ATOM 1362 CB ASP A 184 −28.357 9.672 −85.439 1.00 26.27 C ATOM 1363 CG ASP A 184 −28.767 8.350 −86.073 1.00 26.40 C ATOM 1364 OD1 ASP A 184 −29.828 7.797 −85.723 1.00 26.63 O ATOM 1365 OD2 ASP A 184 −28.027 7.867 −86.950 1.00 26.86 O ATOM 1366 C ASP A 184 −30.586 9.899 −84.192 1.00 27.86 C ATOM 1367 O ASP A 184 −31.230 9.217 −83.377 1.00 27.28 O ATOM 1368 N PRO A 185 −31.176 10.631 −85.179 1.00 29.19 N ATOM 1369 CA PRO A 185 −32.642 10.710 −85.353 1.00 29.34 C ATOM 1370 CB PRO A 185 −32.791 11.532 −86.632 1.00 28.78 C ATOM 1371 CG PRO A 185 −31.624 12.455 −86.584 1.00 29.42 C ATOM 1372 CD PRO A 185 −30.490 11.632 −86.025 1.00 29.03 C ATOM 1373 C PRO A 185 −33.394 9.377 −85.480 1.00 29.96 C ATOM 1374 O PRO A 185 −34.573 9.317 −85.141 1.00 30.82 O ATOM 1375 N GLN A 186 −32.732 8.326 −85.955 1.00 30.37 N ATOM 1376 CA GLN A 186 −33.395 7.031 −86.112 1.00 30.40 C ATOM 1377 CB GLN A 186 −32.817 6.247 −87.302 1.00 30.32 C ATOM 1378 C GLN A 186 −33.348 6.204 −84.828 1.00 30.46 C ATOM 1379 O GLN A 186 −34.088 5.230 −84.700 1.00 32.09 O ATOM 1380 N GLY A 187 −32.489 6.599 −83.882 1.00 29.55 N ATOM 1381 CA GLY A 187 −32.383 5.918 −82.581 1.00 28.32 C ATOM 1382 C GLY A 187 −30.967 5.792 −82.022 1.00 28.11 C ATOM 1383 O GLY A 187 −30.111 6.655 −82.265 1.00 27.13 O ATOM 1384 N ARG A 188 −30.734 4.714 −81.261 1.00 27.44 N ATOM 1385 CA ARG A 188 −29.413 4.393 −80.704 1.00 26.77 C ATOM 1386 CB ARG A 188 −29.467 4.246 −79.184 1.00 26.72 C ATOM 1387 CG ARG A 188 −29.646 5.551 −78.462 1.00 26.79 C ATOM 1388 CD ARG A 188 −28.940 5.599 −77.115 1.00 27.35 C ATOM 1389 NE ARG A 188 −29.392 6.794 −76.397 1.00 27.10 N ATOM 1390 CZ ARG A 188 −29.238 7.014 −75.101 1.00 26.63 C ATOM 1391 NH1 ARG A 188 −28.614 6.134 −74.327 1.00 26.42 N ATOM 1392 NH2 ARG A 188 −29.718 8.127 −74.583 1.00 26.87 N ATOM 1393 C ARG A 188 −28.828 3.119 −81.299 1.00 26.74 C ATOM 1394 O ARG A 188 −29.537 2.119 −81.478 1.00 25.82 O ATOM 1395 N HIS A 189 −27.523 3.156 −81.571 1.00 26.87 N ATOM 1396 CA HIS A 189 −26.838 2.056 −82.259 1.00 27.54 C ATOM 1397 CB HIS A 189 −26.820 2.315 −83.757 1.00 26.15 C ATOM 1398 CG HIS A 189 −28.037 3.045 −84.244 1.00 25.42 C ATOM 1399 ND1 HIS A 189 −29.166 2.406 −84.603 1.00 24.99 N ATOM 1400 CE1 HIS A 189 −30.091 3.313 −84.957 1.00 25.16 C ATOM 1401 NE2 HIS A 189 −29.558 4.537 −84.805 1.00 24.77 N ATOM 1402 CD2 HIS A 189 −28.298 4.407 −84.358 1.00 24.58 C ATOM 1403 C HIS A 189 −25.437 1.858 −81.772 1.00 28.85 C ATOM 1404 O HIS A 189 −24.779 2.804 −81.325 1.00 29.55 O ATOM 1405 N VAL A 190 −24.976 0.615 −81.841 1.00 28.92 N ATOM 1406 CA VAL A 190 −23.572 0.314 −81.643 1.00 28.80 C ATOM 1407 CB VAL A 190 −23.360 −0.959 −80.791 1.00 29.59 C ATOM 1408 CG1 VAL A 190 −24.178 −2.132 −81.324 1.00 30.15 C ATOM 1409 CG2 VAL A 190 −21.880 −1.318 −80.720 1.00 29.68 C ATOM 1410 C VAL A 190 −22.886 −0.195 −83.004 1.00 28.72 C ATOM 1411 O VAL A 190 −23.442 −0.370 −83.953 1.00 28.34 O ATOM 1412 N LYS A 191 −21.691 0.762 −83.095 1.00 29.09 N ATOM 1413 CA LYS A 191 −20.894 0.708 −84.311 1.00 29.81 C ATOM 1414 CB LYS A 191 −20.942 2.053 −85.033 1.00 30.22 C ATOM 1415 CG LYS A 191 −20.592 1.994 −86.509 1.00 31.00 C ATOM 1416 CD LYS A 191 −20.908 3.312 −87.211 1.00 31.44 C ATOM 1417 CE LYS A 191 −21.005 3.132 −88.724 1.00 30.99 C ATOM 1418 NZ LYS A 191 −21.571 4.336 −89.387 1.00 30.24 N ATOM 1419 C LYS A 191 −19.465 0.378 −83.919 1.00 30.13 C ATOM 1420 O LYS A 191 −19.099 0.471 −82.743 1.00 30.38 O ATOM 1421 N THR A 192 −18.672 −0.054 −84.891 1.00 30.43 N ATOM 1422 CA THR A 192 −17.241 −0.240 −84.686 1.00 31.22 C ATOM 1423 CB THR A 192 −16.819 −1.726 −84.657 1.00 31.67 C ATOM 1424 OG1 THR A 192 −17.333 −2.401 −85.816 1.00 31.80 O ATOM 1425 CG2 THR A 192 −17.314 −2.417 −83.391 1.00 30.89 C ATOM 1426 C THR A 192 −16.510 0.428 −85.822 1.00 31.35 C ATOM 1427 O THR A 192 −17.030 0.504 −86.938 1.00 32.20 O ATOM 1428 N TYR A 193 −15.317 0.932 −85.530 1.00 30.36 N ATOM 1429 CA TYR A 193 −14.421 1.411 −86.563 1.00 29.75 C ATOM 1430 CB TYR A 193 −14.279 2.935 −86.532 1.00 28.84 C ATOM 1431 CG TYR A 193 −15.450 3.745 −87.085 1.00 28.44 C ATOM 1432 CD1 TYR A 193 −16.015 3.466 −88.337 1.00 27.25 C ATOM 1433 CE1 TYR A 193 −17.070 4.221 −88.829 1.00 27.08 C ATOM 1434 CZ TYR A 193 −17.559 5.287 −88.075 1.00 28.17 C ATOM 1435 OH TYR A 193 −18.602 6.067 −88.524 1.00 28.24 O ATOM 1436 CE2 TYR A 193 −17.004 5.589 −86.846 1.00 28.45 C ATOM 1437 CD2 TYR A 193 −15.954 4.830 −86.364 1.00 28.37 C ATOM 1438 C TYR A 193 −13.071 0.784 −86.323 1.00 30.33 C ATOM 1439 O TYR A 193 −12.759 0.375 −85.209 1.00 31.44 O ATOM 1440 N GLU A 194 −12.283 0.703 −87.385 1.00 30.63 N ATOM 1441 CA GLU A 194 −10.914 0.245 −87.324 1.00 30.39 C ATOM 1442 CB GLU A 194 −10.665 −0.717 −88.481 1.00 33.28 C ATOM 1443 CG GLU A 194 −9.698 −1.856 −88.210 1.00 36.64 C ATOM 1444 CD GLU A 194 −9.817 −2.961 −89.255 1.00 39.41 C ATOM 1445 OE1 GLU A 194 −8.951 −3.035 −90.165 1.00 41.19 O ATOM 1446 OE2 GLU A 194 −10.795 −3.744 −89.181 1.00 40.37 O ATOM 1447 C GLU A 194 −10.081 1.493 −87.506 1.00 28.80 C ATOM 1448 O GLU A 194 −10.434 2.365 −88.281 1.00 28.62 O ATOM 1449 N VAL A 195 −8.994 1.604 −86.770 1.00 27.88 N ATOM 1450 CA VAL A 195 −8.129 2.754 −86.915 1.00 26.68 C ATOM 1451 CB VAL A 195 −7.591 3.243 −85.559 1.00 25.80 C ATOM 1452 CG1 VAL A 195 −6.633 4.409 −85.748 1.00 25.06 C ATOM 1453 CG2 VAL A 195 −8.745 3.634 −84.650 1.00 25.68 C ATOM 1454 C VAL A 195 −6.987 2.318 −87.782 1.00 26.77 C ATOM 1455 O VAL A 195 −6.177 1.491 −87.376 1.00 28.27 O ATOM 1456 N SER A 196 −6.933 2.848 −88.991 1.00 26.48 N ATOM 1457 CA SER A 196 −5.819 2.553 −89.869 1.00 26.51 C ATOM 1458 CB SER A 196 −6.175 2.892 −91.319 1.00 26.66 C ATOM 1459 OG SER A 196 −5.091 2.631 −92.188 1.00 27.38 O ATOM 1460 C SER A 196 −4.586 3.325 −89.396 1.00 26.37 C ATOM 1461 O SER A 196 −4.512 4.543 −89.535 1.00 26.59 O ATOM 1462 N LEU A 197 −3.644 2.606 −88.794 1.00 26.30 N ATOM 1463 CA LEU A 197 −2.357 3.174 −88.391 1.00 26.62 C ATOM 1464 CB LEU A 197 −1.436 2.058 −87.892 1.00 25.98 C ATOM 1465 CG LEU A 197 −1.433 1.653 −86.416 1.00 26.02 C ATOM 1466 CD1 LEU A 197 −2.704 2.057 −85.684 1.00 26.04 C ATOM 1467 CD2 LEU A 197 −1.174 0.159 −86.277 1.00 26.00 C ATOM 1468 C LEU A 197 −1.665 3.974 −89.518 1.00 27.51 C ATOM 1469 O LEU A 197 −1.223 5.110 −89.298 1.00 28.12 O ATOM 1470 N ARG A 198 −1.591 3.382 −90.714 1.00 26.99 N ATOM 1471 CA ARG A 198 −0.976 4.019 −91.888 1.00 27.63 C ATOM 1472 CB ARG A 198 −0.863 2.978 −93.019 1.00 27.98 C ATOM 1473 CG ARG A 198 −0.380 3.447 −94.391 1.00 26.45 C ATOM 1474 CD ARG A 198 −1.111 2.639 −81.324 1.00 30.15 C ATOM 1475 NE ARG A 198 −0.277 2.268 −96.606 1.00 26.85 N ATOM 1476 CZ ARG A 198 −0.416 2.748 −97.849 1.00 26.13 C ATOM 1477 NH1 ARG A 198 −1.361 3.650 −98.127 1.00 25.69 N ATOM 1478 NH2 ARG A 198 0.395 2.323 −98.820 1.00 24.41 N ATOM 1479 C ARG A 198 −1.752 5.268 −92.351 1.00 28.01 C ATOM 1480 O ARG A 198 −1.227 6.384 −92.349 1.00 26.73 O ATOM 1481 N GLU A 199 −3.011 5.068 −92.720 1.00 29.48 N ATOM 1482 CA GLU A 199 −3.837 6.136 −93.273 1.00 30.76 C ATOM 1483 CB GLU A 199 −5.058 5.549 −94.013 1.00 33.00 C ATOM 1484 CG GLU A 199 −4.718 4.459 −95.036 1.00 35.57 C ATOM 1485 CD GLU A 199 −5.941 3.774 −95.657 1.00 37.42 C ATOM 1486 OE1 GLU A 199 −7.019 3.734 −95.012 1.00 37.84 O ATOM 1487 OE2 GLU A 199 −5.813 3.253 −96.797 1.00 37.41 O ATOM 1488 C GLU A 199 −4.278 7.154 −92.208 1.00 30.22 C ATOM 1489 O GLU A 199 −4.779 8.224 −92.547 1.00 31.90 O ATOM 1490 N LYS A 200 −4.076 6.824 −90.931 1.00 28.90 N ATOM 1491 CA LYS A 200 −4.519 7.669 −89.811 1.00 27.59 C ATOM 1492 CB LYS A 200 −3.641 8.911 −89.681 1.00 27.26 C ATOM 1493 CG LYS A 200 −2.387 8.624 −88.897 1.00 27.19 C ATOM 1494 CD LYS A 200 −1.301 9.656 −89.115 1.00 27.29 C ATOM 1495 CE LYS A 200 0.046 9.004 −88.861 1.00 27.37 C ATOM 1496 NZ LYS A 200 0.112 7.658 −89.517 1.00 26.79 N ATOM 1497 C LYS A 200 −5.980 8.049 −89.942 1.00 26.94 C ATOM 1498 O LYS A 200 −6.346 9.22 −89.882 1.00 26.83 O ATOM 1499 N GLU A 201 −6.813 7.034 −90.118 1.00 26.14 N ATOM 1500 CA GLU A 201 −8.199 7.243 −90.481 1.00 25.32 C ATOM 1501 CB GLU A 201 −8.291 7.478 −91.988 1.00 25.76 C ATOM 1502 CG GLU A 201 −9.435 8.383 −92.389 1.00 27.20 C ATOM 1503 CD GLU A 201 −9.186 9.859 −92.101 1.00 28.10 C ATOM 1504 OE1 GLU A 201 −8.167 10.423 −92.578 1.00 27.31 O ATOM 1505 OE2 GLU A 201 −10.041 10.466 −91.414 1.00 29.44 O ATOM 1506 C GLU A 201 −9.036 6.039 −90.081 1.00 23.71 C ATOM 1507 O GLU A 201 −8.505 4.959 −89.832 1.00 22.65 O ATOM 1508 N PHE A 202 −10.345 6.226 −90.008 1.00 23.07 N ATOM 1509 CA PHE A 202 −11.218 5.115 −89.686 1.00 23.55 C ATOM 1510 CB PHE A 202 −12.539 5.582 −89.074 1.00 23.46 C ATOM 1511 CG PHE A 202 −12.420 6.012 −87.647 1.00 24.09 C ATOM 1512 CD1 PHE A 202 −11.781 5.196 −86.704 1.00 24.64 C ATOM 1513 CE1 PHE A 202 −11.667 5.599 −85.380 1.00 24.17 C ATOM 1514 CZ PHE A 202 −12.188 6.819 −84.987 1.00 23.65 C ATOM 1515 CE2 PHE A 202 −12.821 7.633 −85.913 1.00 23.46 C ATOM 1516 CD2 PHE A 202 −12.941 7.229 −87.231 1.00 23.94 C ATOM 1517 C PHE A 202 −11.471 4.224 −90.887 1.00 23.84 C ATOM 1518 O PHE A 202 −11.632 4.691 −92.018 1.00 24.14 O ATOM 1519 N ASN A 203 −11.488 2.929 −90.622 1.00 24.43 N ATOM 1520 CA ASN A 203 −11.818 1.942 −91.614 1.00 25.87 C ATOM 1521 CB ASN A 203 −10.677 0.926 −91.750 1.00 26.41 C ATOM 1522 CG ASN A 203 −9.729 1.245 −92.900 1.00 27.01 C ATOM 1523 OD1 ASN A 203 −9.238 2.370 −93.044 1.00 27.27 O ATOM 1524 ND2 ASN A 203 −9.461 0.243 −93.723 1.00 27.79 N ATOM 1525 C ASN A 203 −13.109 1.249 −91.219 1.00 26.46 C ATOM 1526 O ASN A 203 −13.417 1.125 −90.030 1.00 26.09 O ATOM 1527 N LYS A 204 −13.877 0.812 −92.210 1.00 27.50 N ATOM 1528 CA LYS A 204 −15.061 0.014 −91.928 1.00 28.53 C ATOM 1529 CB LYS A 204 −15.606 −0.606 −93.216 1.00 29.27 C ATOM 1530 CG LYS A 204 −16.958 −1.290 −93.067 1.00 29.82 C ATOM 1531 CD LYS A 204 −17.241 −2.183 −94.264 1.00 31.19 C ATOM 1532 CE LYS A 204 −16.315 −3.397 −94.291 1.00 31.96 C ATOM 1533 NZ LYS A 204 −16.005 −3.824 −95.687 1.00 31.84 N ATOM 1534 C LYS A 204 −14.714 −1.065 −90.885 1.00 27.82 C ATOM 1535 O LYS A 204 −13.799 −1.867 −91.078 1.00 26.77 O ATOM 1536 N GLY A 205 −15.422 −1.044 −89.764 1.00 27.76 N ATOM 1537 CA GLY A 205 −15.170 −2.000 −88.685 1.00 28.67 C ATOM 1538 C GLY A 205 −15.764 −3.386 −88.904 1.00 28.70 C ATOM 1539 O GLY A 205 −16.508 −3.602 −89.866 1.00 28.44 O ATOM 1540 N PRO A 206 −15.456 −4.331 −87.993 1.00 28.50 N ATOM 1541 CA PRO A 206 −15.907 −5.726 −88.065 1.00 29.54 C ATOM 1542 CB PRO A 206 −15.412 −6.326 −86.740 1.00 28.82 C ATOM 1543 CG PRO A 206 −14.289 −5.456 −86.317 1.00 28.98 C ATOM 1544 CD PRO A 206 −14.631 −4.081 −86.798 1.00 28.45 C ATOM 1545 C PRO A 206 −17.434 −5.914 −88.189 1.00 31.10 C ATOM 1546 O PRO A 206 −17.883 −6.866 −88.840 1.00 31.00 O ATOM 1547 N TRP A 207 −18.208 −5.017 −87.570 1.00 32.66 N ATOM 1548 CA TRP A 207 −19.661 −5.166 −87.439 1.00 33.85 C ATOM 1549 CB TRP A 207 −19.989 −6.382 −86.582 1.00 33.95 C ATOM 1550 CG TRP A 207 −19.161 −6.483 −85.316 1.00 33.72 C ATOM 1551 CD1 TRP A 207 −17.971 −7.181 −85.137 1.00 33.60 C ATOM 1552 NE1 TRP A 207 −17.508 −7.041 −83.852 1.00 33.99 N ATOM 1553 CE2 TRP A 207 −18.340 −6.271 −83.125 1.00 33.45 C ATOM 1554 CD2 TRP A 207 −19.441 −5.871 −84.009 1.00 33.98 C ATOM 1555 CE3 TRP A 207 −20.455 −5.061 −83.502 1.00 34.90 C ATOM 1556 CZ3 TRP A 207 −20.385 −4.666 −82.157 1.00 34.82 C ATOM 1557 CH2 TRP A 207 −19.322 −5.065 −81.328 1.00 34.52 C ATOM 1558 CZ2 TRP A 207 −18.280 −5.875 −81.800 1.00 33.55 C ATOM 1559 C TRP A 207 −20.310 −3.949 −86.829 1.00 36.06 C ATOM 1560 O TRP A 207 −19.630 −3.016 −86.393 1.00 35.38 O ATOM 1561 N LYS A 208 −21.643 −3.963 −86.788 1.00 37.78 N ATOM 1562 CA LYS A 208 −22.440 −2.891 −86.178 1.00 38.59 C ATOM 1563 CB LYS A 208 −22.447 −1.632 −87.064 1.00 38.30 C ATOM 1564 CG LYS A 208 −23.436 −1.670 −88.219 1.00 37.96 C ATOM 1565 CD LYS A 208 −22.950 −0.843 −89.399 1.00 38.94 C ATOM 1566 CE LYS A 208 −24.014 −0.798 −90.485 1.00 39.77 C ATOM 1567 NZ LYS A 208 −23.473 −1.005 −91.857 1.00 39.49 N ATOM 1568 C LYS A 208 −23.867 −3.389 −85.915 1.00 39.21 C ATOM 1569 O LYS A 208 −24.243 −4.471 −86.372 1.00 38.66 O ATOM 1570 N GLN A 209 −24.655 −2.600 −85.183 1.00 39.76 N ATOM 1571 CA GLN A 209 −26.003 −3.007 −84.781 1.00 39.69 C ATOM 1572 CB GLN A 209 −25.937 −4.262 −83.877 1.00 41.60 C ATOM 1573 CG GLN A 209 −27.036 −4.432 −82.831 1.00 43.27 C ATOM 1574 CD GLN A 209 −28.396 −4.738 −83.426 1.00 42.94 C ATOM 1575 OE1 GLN A 209 −29.162 −3.822 −83.742 1.00 42.95 O ATOM 1576 NE2 GLN A 209 −28.718 −6.028 −83.551 1.00 41.02 N ATOM 1577 C GLN A 209 −26.749 −1.859 −84.114 1.00 37.69 C ATOM 1578 O GLN A 209 −27.763 −1.399 −84.630 1.00 36.15 O ATOM 1579 N ASN A 211 −30.512 −1.432 −84.300 1.00 31.68 N ATOM 1580 CA ASN A 211 −30.771 −0.409 −83.303 1.00 32.92 C ATOM 1581 CB ASN A 211 −32.033 0.381 −83.665 1.00 31.58 C ATOM 1582 C ASN A 211 −30.886 −1.015 −81.895 1.00 34.40 C ATOM 1583 O ASN A 211 −31.819 −1.766 −81.615 1.00 35.72 O ATOM 1584 N VAL A 212 −29.929 −0.683 −81.021 1.00 34.41 N ATOM 1585 CA VAL A 212 −29.894 −1.192 −79.634 1.00 32.85 C ATOM 1586 CB VAL A 212 −28.534 −0.919 −78.946 1.00 32.03 C ATOM 1587 CG1 VAL A 212 −27.435 −1.766 −79.574 1.00 31.19 C ATOM 1588 CG2 VAL A 212 −28.190 0.564 −78.991 1.00 30.35 C ATOM 1589 C VAL A 212 −31.006 −0.603 −78.768 1.00 32.29 C ATOM 1590 O VAL A 212 −31.848 0.154 −79.257 1.00 32.29 O ATOM 1591 N GLU A 213 −31.003 −0.954 −77.482 1.00 31.61 N ATOM 1592 CA GLU A 213 −31.993 −0.431 −76.541 1.00 31.40 C ATOM 1593 CB GLU A 213 −31.747 −0.988 −75.144 1.00 31.73 C ATOM 1594 CG GLU A 213 −32.941 −0.853 −74.222 1.00 33.60 C ATOM 1595 CD GLU A 213 −32.563 −0.853 −72.751 1.00 35.20 C ATOM 1596 OE1 GLU A 213 −31.764 −1.724 −72.331 1.00 35.36 O ATOM 1597 OE2 GLU A 213 −33.080 0.021 −72.014 1.00 35.65 O ATOM 1598 C GLU A 213 −31.958 1.095 −76.509 1.00 30.71 C ATOM 1599 O GLU A 213 −30.895 1.698 −76.641 1.00 31.04 O ATOM 1600 N ALA A 214 −33.126 1.710 −76.337 1.00 30.32 N ATOM 1601 CA ALA A 214 −33.259 3.172 −76.309 1.00 30.22 C ATOM 1602 CB ALA A 214 −34.678 3.559 −75.933 1.00 29.33 C ATOM 1603 C ALA A 214 −32.280 3.852 −75.361 1.00 31.17 C ATOM 1604 O ALA A 214 −31.848 4.973 −75.611 1.00 31.91 O ATOM 1605 N GLU A 215 −31.929 3.158 −74.283 1.00 31.76 N ATOM 1606 CA GLU A 215 −31.313 3.778 −73.127 1.00 31.10 C ATOM 1607 CB GLU A 215 −32.266 3.653 −71.943 1.00 32.49 C ATOM 1608 CG GLU A 215 −32.093 4.723 −70.880 1.00 34.34 C ATOM 1609 CD GLU A 215 −32.505 6.094 −71.352 1.00 34.85 C ATOM 1610 OE1 GLU A 215 −31.677 7.028 −71.219 1.00 36.66 O ATOM 1611 OE2 GLU A 215 −33.648 6.233 −71.847 1.00 33.85 O ATOM 1612 C GLU A 215 −29.965 3.139 −72.809 1.00 30.84 C ATOM 1613 O GLU A 215 −29.317 3.473 −71.811 1.00 30.20 O ATOM 1614 N ALA A 216 −29.555 2.212 −73.671 1.00 30.68 N ATOM 1615 CA ALA A 216 −28.214 1.635 −73.639 1.00 29.99 C ATOM 1616 CB ALA A 216 −27.961 0.838 −74.910 1.00 29.10 C ATOM 1617 C ALA A 216 −27.189 2.746 −73.506 1.00 29.69 C ATOM 1618 O ALA A 216 −27.276 3.753 −74.212 1.00 31.05 O ATOM 1619 N SER A 217 −26.225 2.572 −72.603 1.00 28.96 N ATOM 1620 CA SER A 217 −25.233 3.615 −72.361 1.00 28.67 C ATOM 1621 CB SER A 217 −25.764 4.615 −71.348 1.00 28.16 C ATOM 1622 OG SER A 217 −36.039 3.976 −70.125 1.00 27.90 O ATOM 1623 C SER A 217 −23.851 3.139 −71.929 1.00 29.31 C ATOM 1624 O SER A 217 −22.932 3.938 −71.826 1.00 30.80 O ATOM 1625 N MET A 218 −23.683 1.851 −71.674 1.00 30.27 N ATOM 1626 CA MET A 218 −22.395 1.391 −71.178 1.00 30.13 C ATOM 1627 CB MET A 218 −22.529 0.872 −69.763 1.00 32.83 C ATOM 1628 CG MET A 218 −21.197 0.765 −69.052 1.00 38.16 C ATOM 1629 SD MET A 218 −21.312 −0.189 −67.529 1.00 45.93 S ATOM 1630 CE MET A 218 −22.435 0.857 −66.599 1.00 40.00 C ATOM 1631 C MET A 218 −21.756 0.341 −72.072 1.00 28.53 C ATOM 1632 O MET A 218 −22.355 −0.683 −72.370 1.00 28.48 O ATOM 1633 N VAL A 219 −20.533 0.607 −72.499 1.00 26.75 N ATOM 1634 CA VAL A 219 −19.814 −0.330 −73.338 1.00 25.90 C ATOM 1635 CB VAL A 219 −19.142 0.374 −74.538 1.00 26.68 C ATOM 1636 CG1 VAL A 219 −18.560 −0.655 −75.501 1.00 26.66 C ATOM 1637 CG2 VAL A 219 −20.136 1.267 −75.266 1.00 26.74 C ATOM 1638 C VAL A 219 −18.765 −1.057 −72.510 1.00 24.67 C ATOM 1639 O VAL A 219 −18.037 −0.436 −71.737 1.00 24.45 O ATOM 1640 N ILE A 220 −18.708 −2.373 −72.668 1.00 23.56 N ATOM 1641 CA ILE A 220 −17.724 −3.196 −71.984 1.00 23.46 C ATOM 1642 CB ILE A 220 −18.389 −4.079 −70.913 1.00 23.65 C ATOM 1643 CG1 ILE A 220 −18.909 −3.216 −69.751 1.00 23.94 C ATOM 1644 CD1 ILE A 220 −19.905 −3.916 −68.837 1.00 23.96 C ATOM 1645 CG2 ILE A 220 −17.423 −5.150 −70.427 1.00 23.22 C ATOM 1646 C ILE A 220 −17.038 −4.082 −73.010 1.00 23.66 C ATOM 1647 O ILE A 220 −17.693 −4.865 −73.697 1.00 24.86 O ATOM 1648 N ALA A 221 −15.724 −3.954 −73.134 1.00 23.10 N ATOM 1649 CA ALA A 221 −14.987 −4.787 −74.065 1.00 23.40 C ATOM 1650 CB ALA A 221 −13.799 −4.033 −74.630 1.00 22.94 C ATOM 1651 C ALA A 221 −14.553 −6.098 −73.390 1.00 24.47 C ATOM 1652 O ALA A 221 −13.815 −6.104 −72.393 1.00 24.74 O ATOM 1653 N VAL A 222 −15.045 −7.207 −73.923 1.00 24.96 N ATOM 1654 CA VAL A 222 −14.801 −8.510 −73.339 1.00 25.78 C ATOM 1655 CB VAL A 222 −15.947 −9.470 −73.688 1.00 25.88 C ATOM 1656 CG1 VAL A 222 −15.716 −10.838 −73.081 1.00 27.48 C ATOM 1657 CG2 VAL A 222 −17.275 −8.905 −73.213 1.00 25.16 C ATOM 1658 C VAL A 222 −13.472 −9.032 −73.874 1.00 27.25 C ATOM 1659 O VAL A 222 −13.223 −8.940 −75.082 1.00 28.38 O ATOM 1660 N PRO A 223 −12.600 −9.553 −72.983 1.00 28.37 N ATOM 1661 CA PRO A 223 −11.277 −10.032 −73.387 1.00 30.57 C ATOM 1662 CB PRO A 223 −10.579 −10.311 −72.050 1.00 28.69 C ATOM 1663 CG PRO A 223 −11.289 −9.458 −71.077 1.00 28.92 C ATOM 1664 CD PRO A 223 −12.718 −9.520 −71.518 1.00 29.13 C ATOM 1665 C PRO A 223 −11.283 −11.293 −74.261 1.00 34.13 C ATOM 1666 O PRO A 223 −12.342 −11.788 −74.666 1.00 33.68 O ATOM 1667 N GLU A 224 −10.087 −11.803 −74.528 1.00 38.30 N ATOM 1668 CA GLU A 224 −9.901 −12.868 −75.488 1.00 42.84 C ATOM 1669 CB GLU A 224 −8.548 −12.730 −76.194 1.00 44.92 C ATOM 1670 CG GLU A 224 −8.657 −12.522 −77.691 1.00 47.93 C ATOM 1671 CD GLU A 224 −7.316 −12.619 −78.388 1.00 51.61 C ATOM 1672 OE1 GLU A 224 −7.305 −12.810 −79.623 1.00 54.35 O ATOM 1673 OE2 GLU A 224 −6.272 −12.507 −77.705 1.00 53.67 O ATOM 1674 C GLU A 224 −10.049 −14.286 −74.961 1.00 45.23 C ATOM 1675 O GLU A 224 −9.109 −14.868 −74.415 1.00 50.26 O ATOM 1676 N PRO A 225 −11.268 −14.796 −74.999 1.00 45.04 N ATOM 1677 CA PRO A 225 −11.436 −15.922 −75.892 1.00 42.48 C ATOM 1678 CB PRO A 225 −11.815 −17.084 −74.957 1.00 41.54 C ATOM 1679 CG PRO A 225 −11.974 −16.486 −73.586 1.00 44.50 C ATOM 1680 CD PRO A 225 −12.032 −14.987 −73.759 1.00 45.55 C ATOM 1681 C PRO A 225 −12.585 −15.518 −76.814 1.00 40.96 C ATOM 1682 O PRO A 225 −12.447 −15.550 −78.029 1.00 40.45 O ATOM 1683 N PHE A 226 −13.675 −15.046 −76.214 1.00 40.06 N ATOM 1684 CA PHE A 226 −14.888 −14.695 −76.931 1.00 39.76 C ATOM 1685 CB PHE A 226 −16.083 −14.667 −75.969 1.00 43.33 C ATOM 1686 CG PHE A 226 −16.157 −15.861 −75.049 1.00 47.14 C ATOM 1687 CD1 PHE A 226 −16.045 −17.161 −75.549 1.00 48.45 C ATOM 1688 CE1 PHE A 226 −16.105 −18.260 −74.700 1.00 49.77 C ATOM 1689 CZ PHE A 226 −16.299 −18.075 −73.339 1.00 50.79 C ATOM 1690 CE2 PHE A 226 −16.421 −16.789 −72.827 1.00 51.35 C ATOM 1691 CD2 PHE A 226 −16.350 −15.690 −73.681 1.00 50.20 C ATOM 1692 C PHE A 226 −14.776 −13.365 −77.661 1.00 37.65 C ATOM 1693 O PHE A 226 −15.412 −13.170 −78.699 1.00 37.27 O ATOM 1694 N GLY A 227 −13.966 −12.455 −77.118 1.00 36.18 N ATOM 1695 CA GLY A 227 −13.897 −11.078 −77.612 1.00 32.64 C ATOM 1696 C GLY A 227 −15.278 −10.447 −77.616 1.00 31.15 C ATOM 1697 O GLY A 227 −16.182 −10.898 −76.912 1.00 31.68 O ATOM 1698 N GLY A 228 −15.449 −9.403 −78.411 1.00 29.35 N ATOM 1699 CA GLY A 228 −16.759 −8.771 −78.558 1.00 27.00 C ATOM 1700 C GLY A 228 −17.058 −7.701 −77.531 1.00 25.20 C ATOM 1701 O GLY A 228 −16.173 −7.269 −76.783 1.00 25.26 O ATOM 1702 N ALA A 229 −18.311 −7.266 −77.504 1.00 23.57 N ATOM 1703 CA ALA A 229 −18.716 −6.191 −76.622 1.00 22.36 C ATOM 1704 CB ALA A 229 −18.875 −4.903 −77.411 1.00 21.89 C ATOM 1705 C ALA A 229 −20.009 −6.527 −75.895 1.00 22.21 C ATOM 1706 O ALA A 229 −20.910 −7.162 −76.459 1.00 22.38 O ATOM 1707 N ILE A 230 −20.087 −6.101 −74.637 1.00 21.80 N ATOM 1708 CA ILE A 230 −21.324 −6.132 −73.868 1.00 21.72 C ATOM 1709 CB ILE A 230 −21.063 −6.683 −72.455 1.00 21.75 C ATOM 1710 CG1 ILE A 230 −20.922 −8.199 −72.523 1.00 21.59 C ATOM 1711 CD1 ILE A 230 −20.459 −8.817 −71.233 1.00 21.82 C ATOM 1712 CG2 ILE A 230 −22.178 −6.299 −71.488 1.00 21.71 C ATOM 1713 C ILE A 230 −21.888 −4.719 −73.792 1.00 21.79 C ATOM 1714 O ILE A 230 −21.130 −3.762 −73.629 1.00 21.97 O ATOM 1715 N ILE A 231 −23.209 −4.590 −73.924 1.00 21.67 N ATOM 1716 CA ILE A 231 −23.881 −3.293 −73.807 1.00 22.17 C ATOM 1717 CB ILE A 231 −24.546 −2.845 −75.142 1.00 21.62 C ATOM 1718 CG1 ILE A 231 −23.565 −2.904 −76.321 1.00 21.68 C ATOM 1719 CD1 ILE A 231 −22.327 −2.039 −76.188 1.00 21.31 C ATOM 1720 CG2 ILE A 231 −25.125 −1.447 −75.015 1.00 21.49 C ATOM 1721 C ILE A 231 −24.934 −3.320 −72.696 1.00 23.01 C ATOM 1722 O ILE A 231 −25.899 −4.072 −72.770 1.00 23.93 O ATOM 1723 N ILE A 232 −24.746 −2.501 −71.668 1.00 23.83 N ATOM 1724 CA ILE A 232 −25.734 −2.376 −70.596 1.00 24.82 C ATOM 1725 CB ILE A 232 −25.052 −2.112 −69.231 1.00 24.87 C ATOM 1726 CG1 ILE A 232 −23.901 −3.097 −68.972 1.00 24.65 C ATOM 1727 CD1 ILE A 232 −24.326 −4.511 −68.626 1.00 24.13 C ATOM 1728 CG2 ILE A 232 −26.070 −2.142 −68.096 1.00 24.97 C ATOM 1729 C ILE A 232 −26.695 −1.223 −70.904 1.00 26.09 C ATOM 1730 O ILE A 232 −26.255 −0.152 −71.322 1.00 25.85 O ATOM 1731 N GLY A 233 −27.997 −1.449 −70.694 1.00 27.62 N ATOM 1732 CA GLY A 233 −29.029 −0.409 −70.855 1.00 29.52 C ATOM 1733 C GLY A 233 −29.906 −0.204 −69.624 1.00 32.48 C ATOM 1734 O GLY A 233 −29.444 −0.321 −68.491 1.00 33.12 O ATOM 1735 N GLN A 234 −31.178 0.113 −69.841 1.00 35.79 N ATOM 1736 CA GLN A 234 −32.116 0.288 −68.733 1.00 38.37 C ATOM 1737 CB GLN A 234 −33.232 1.263 −69.090 1.00 41.39 C ATOM 1738 CG GLN A 234 −33.113 2.613 −68.400 1.00 44.93 C ATOM 1739 CD GLN A 234 −33.858 2.666 −67.086 1.00 47.29 C ATOM 1740 OE1 GLN A 234 −33.257 2.567 −66.013 1.00 49.39 O ATOM 1741 NE2 GLN A 234 −35.181 2.819 −67.161 1.00 47.35 N ATOM 1742 C GLN A 234 −32.704 −1.019 −68.263 1.00 40.13 C ATOM 1743 O GLN A 234 −32.795 −1.245 −67.055 1.00 40.62 O ATOM 1744 N GLU A 235 −33.126 −1.871 −69.201 1.00 41.75 N ATOM 1745 CA GLU A 235 −33.531 −3.234 −68.830 1.00 43.55 C ATOM 1746 CB GLU A 235 −35.061 −3.418 −68.786 1.00 47.09 C ATOM 1747 CG GLU A 235 −35.462 −4.694 −68.027 1.00 49.80 C ATOM 1748 CD GLU A 235 −36.888 −4.696 −67.505 1.00 52.00 C ATOM 1749 OE1 GLU A 235 −37.633 −5.640 −67.845 1.00 52.60 O ATOM 1750 OE2 GLU A 235 −37.259 −3.774 −66.740 1.00 52.21 O ATOM 1751 C GLU A 235 −32.869 −4.360 −69.625 1.00 41.20 C ATOM 1752 O GLU A 235 −33.101 −5.542 −69.341 1.00 41.06 O ATOM 1753 N SER A 236 −32.036 −4.014 −70.598 1.00 36.56 N ATOM 1754 CA SER A 236 −31.339 −5.056 −71.341 1.00 32.91 C ATOM 1755 CB SER A 236 −31.773 −5.108 −72.811 1.00 32.30 C ATOM 1756 OG SER A 236 −32.425 −3.921 −73.204 1.00 32.43 O ATOM 1757 C SER A 236 −29.827 −5.013 −71.206 1.00 30.49 C ATOM 1758 O SER A 236 −29.220 −3.948 −71.091 1.00 31.15 O ATOM 1759 N ILE A 237 −29.244 −6.203 −71.185 1.00 27.70 N ATOM 1760 CA ILE A 237 −27.811 −6.398 −71.239 1.00 25.90 C ATOM 1761 CB ILE A 237 −27.313 −7.108 −69.957 1.00 24.12 C ATOM 1762 CG1 ILE A 237 −27.414 −6.155 −68.777 1.00 23.51 C ATOM 1763 CD1 ILE A 237 −27.319 −6.827 −67.436 1.00 23.62 C ATOM 1764 CG2 ILE A 237 −25.885 −7.594 −70.099 1.00 23.58 C ATOM 1765 C ILE A 237 −27.613 −7.246 −72.485 1.00 25.70 C ATOM 1766 O ILE A 237 −28.253 −8.282 −72.630 1.00 26.10 O ATOM 1767 N THR A 238 −26.759 −6.789 −73.394 1.00 26.10 N ATOM 1768 CA THR A 238 −26.696 −7.352 −74.747 1.00 28.01 C ATOM 1769 CB THR A 238 −27.337 −6.399 −75.794 1.00 29.62 C ATOM 1770 OG1 THR A 238 −28.498 −5.758 −75.242 1.00 30.87 O ATOM 1771 CG2 THR A 238 −27.750 −7.167 −77.028 1.00 30.15 C ATOM 1772 C THR A 238 −25.263 −7.617 −75.174 1.00 27.71 C ATOM 1773 O THR A 238 −24.378 −6.804 −74.921 1.00 29.31 O ATOM 1774 N TYR A 239 −25.033 −8.745 −75.835 1.00 27.10 N ATOM 1775 CA TYR A 239 −23.692 −9.089 −76.289 1.00 27.50 C ATOM 1776 CB TYR A 239 −23.246 −10.438 −75.730 1.00 26.88 C ATOM 1777 CG TYR A 239 −21.961 −10.936 −76.336 1.00 26.37 C ATOM 1778 CD1 TYR A 239 −20.741 −10.537 −75.831 1.00 26.77 C ATOM 1779 CE1 TYR A 239 −19.553 −10.984 −76.384 1.00 26.80 C ATOM 1780 CZ TYR A 239 −19.578 −11.835 −77.461 1.00 26.27 C ATOM 1781 OH TYR A 239 −18.390 −12.268 −78.002 1.00 25.46 O ATOM 1782 CE2 TYR A 239 −20.784 −12.245 −77.990 1.00 26.75 C ATOM 1783 CD2 TYR A 239 −21.967 −11.797 −77.426 1.00 26.73 C ATOM 1784 C TYR A 239 −23.613 −9.109 −77.803 1.00 28.89 C ATOM 1785 O TYR A 239 −24.563 −9.540 −78.470 1.00 29.54 O ATOM 1786 N HIS A 240 −22.470 −8.654 −78.331 1.00 28.93 N ATOM 1787 CA HIS A 240 −22.222 −8.596 −79.771 1.00 28.64 C ATOM 1788 CB HIS A 240 −22.455 −7.185 −80.300 1.00 28.37 C ATOM 1789 CG HIS A 240 −23.602 −6.472 −79.643 1.00 28.79 C ATOM 1790 ND1 HIS A 240 −24.851 −6.508 −80.135 1.00 29.65 N ATOM 1791 CE1 HIS A 240 −25.668 −5.794 −79.338 1.00 29.46 C ATOM 1792 NE2 HIS A 240 −24.936 −5.305 −78.323 1.00 29.32 N ATOM 1793 CD2 HIS A 240 −23.658 −5.704 −78.481 1.00 28.87 C ATOM 1794 C HIS A 240 −20.814 −8.990 −80.085 1.00 29.37 C ATOM 1795 O HIS A 240 −19.876 −8.590 −79.391 1.00 30.12 O ATOM 1796 N ASN A 241 −20.660 −9.785 −81.137 1.00 29.55 N ATOM 1797 CA ASN A 241 −19.370 −10.034 −81.782 1.00 30.91 C ATOM 1798 CB ASN A 241 −18.509 −11.031 −80.995 1.00 29.37 C ATOM 1799 CG ASN A 241 −17.085 −11.150 −81.542 1.00 28.87 C ATOM 1800 OD1 ASN A 241 −16.738 −10.558 −82.566 1.00 28.82 O ATOM 1801 ND2 ASN A 241 −16.248 −11.910 −80.843 1.00 29.00 N ATOM 1802 C ASN A 241 −19.651 −10.588 −83.157 1.00 33.90 C ATOM 1803 O ASN A 241 −20.477 −11.499 −83.308 1.00 36.55 O ATOM 1804 N GLY A 242 −18.966 −10.058 −84.166 1.00 35.94 N ATOM 1805 CA GLY A 242 −19.284 −10.422 −85.532 1.00 37.89 C ATOM 1806 C GLY A 242 −20.793 −10.387 −85.585 1.00 39.80 C ATOM 1807 O GLY A 242 −21.406 −9.370 −85.228 1.00 39.92 O ATOM 1808 N ASP A 243 −21.406 −11.507 −85.951 1.00 41.08 N ATOM 1809 CA ASP A 243 −22.867 −11.538 −86.011 1.00 43.07 C ATOM 1810 CB ASP A 243 −23.369 −11.639 −87.467 1.00 45.40 C ATOM 1811 CG ASP A 243 −23.229 −10.298 −88.236 1.00 49.13 C ATOM 1812 OD1 ASP A 243 −22.105 −9.729 −88.302 1.00 48.25 O ATOM 1813 OD2 ASP A 243 −24.249 −9.809 −88.776 1.00 50.45 O ATOM 1814 C ASP A 243 −23.544 −12.526 −85.039 1.00 41.42 C ATOM 1815 O ASP A 243 −24.722 −12.854 −85.189 1.00 40.42 O ATOM 1816 N LYS A 244 −22.795 −12.962 −84.025 1.00 40.38 N ATOM 1817 CA LYS A 244 −23.392 −13.549 −82.822 1.00 39.22 C ATOM 1818 CB LYS A 244 −22.329 −14.204 −81.943 1.00 39.54 C ATOM 1819 CG LYS A 244 −22.909 −15.082 −80.841 1.00 40.32 C ATOM 1820 CD LYS A 244 −21.827 −15.601 −79.909 1.00 41.13 C ATOM 1821 CE LYS A 244 −21.861 −17.121 −79.830 1.00 41.84 C ATOM 1822 NZ LYS A 244 −23.246 −17.642 −79.641 1.00 42.76 N ATOM 1823 C LYS A 244 −24.095 −12.437 −82.033 1.00 37.58 C ATOM 1824 O LYS A 244 −23.708 −11.267 −82.125 1.00 37.70 O ATOM 1825 N TYR A 245 −25.112 −12.803 −81.254 1.00 34.72 N ATOM 1826 CA TYR A 245 −25.930 −11.819 −80.555 1.00 33.47 C ATOM 1827 CB TYR A 245 −26.822 −11.082 −81.554 1.00 33.15 C ATOM 1828 CG TYR A 245 −27.835 −10.160 −80.943 1.00 33.23 C ATOM 1829 CD1 TYR A 245 −29.101 −10.622 −80.594 1.00 33.25 C ATOM 1830 CE1 TYR A 245 −30.052 −9.778 −80.044 1.00 33.68 C ATOM 1831 CZ TYR A 245 −29.749 −8.445 −79.845 1.00 34.55 C ATOM 1832 OH TYR A 245 −30.698 −7.605 −79.289 1.00 33.85 O ATOM 1833 CE2 TYR A 245 −28.494 −7.958 −80.194 1.00 35.67 C ATOM 1834 CD2 TYR A 245 −27.546 −8.818 −80.742 1.00 34.48 C ATOM 1835 C TYR A 245 −26.764 −12.450 −79.446 1.00 33.17 C ATOM 1836 O TYR A 245 −27.569 −13.349 −79.687 1.00 32.82 O ATOM 1837 N LEU A 246 −26.555 −11.967 −78.225 1.00 33.25 N ATOM 1838 CA LEU A 246 −27.256 −12.472 −77.46 1.00 32.52 C ATOM 1839 CB LEU A 246 −26.275 −13.162 −76.096 1.00 32.21 C ATOM 1840 CG LEU A 246 −25.865 −14.620 −76.369 1.00 32.65 C ATOM 1841 CD1 LEU A 246 −25.224 −14.834 −77.734 1.00 33.00 C ATOM 1842 CD2 LEU A 246 −24.914 −15.095 −75.283 1.00 34.04 C ATOM 1843 C LEU A 246 −27.941 −11.310 −76.349 1.00 31.84 C ATOM 1844 O LEU A 246 −27.392 −10.208 −76.305 1.00 32.66 O ATOM 1845 N ALA A 247 −29.145 −11.549 −75.829 1.00 30.72 N ATOM 1846 CA ALA A 247 −29.947 −10.486 −75.210 1.00 29.56 C ATOM 1847 CB ALA A 247 −30.870 −9.843 −76.234 1.00 29.19 C ATOM 1848 C ALA A 247 −30.753 −10.986 −74.024 1.00 28.47 C ATOM 1849 O ALA A 247 −31.720 −11.717 −74.196 1.00 29.21 O ATOM 1850 N ILE A 248 −30.339 −10.603 −72.820 1.00 27.16 N ATOM 1851 CA ILE A 248 −31.151 −10.836 −71.629 1.00 26.11 C ATOM 1852 CB ILE A 248 −30.360 −11.485 −70.470 1.00 25.38 C ATOM 1853 CG1 ILE A 248 −29.053 −10.735 −70.225 1.00 24.83 C ATOM 1854 CD1 ILE A 248 −28.634 −10.745 −68.777 1.00 24.76 C ATOM 1855 CG2 ILE A 248 −30.126 −12.970 −70.738 1.00 24.96 C ATOM 1856 C ILE A 248 −31.769 −9.534 −71.147 1.00 25.49 C ATOM 1857 O ILE A 248 −31.159 −8.464 −71.257 1.00 25.31 O ATOM 1858 N ALA A 249 −32.986 −9.642 −70.622 1.00 24.53 N ATOM 1859 CA ALA A 249 −33.699 −8.517 −70.040 1.00 23.38 C ATOM 1860 CB ALA A 249 −34.798 −8.053 −70.978 1.00 23.47 C ATOM 1861 C ALA A 249 −34.279 −8.929 −68.691 1.00 22.58 C ATOM 1862 O ALA A 249 −35.496 −9.027 −68.544 1.00 22.59 O ATOM 1863 N PRO A 250 −33.406 −9.165 −67.694 1.00 22.02 N ATOM 1864 CA PRO A 250 −33.877 −9.706 −66.425 1.00 21.88 C ATOM 1865 CB PRO A 250 −32.582 −10.102 −65.712 1.00 21.75 C ATOM 1866 CG PRO A 250 −31.556 −9.168 −66.248 1.00 21.66 C ATOM 1867 CD PRO A 250 −31.974 −8.806 −67.648 1.00 22.03 C ATOM 1868 C PRO A 250 −34.659 −8.681 −65.604 1.00 22.12 C ATOM 1869 O PRO A 250 −34.466 −7.475 −65.774 1.00 21.78 O ATOM 1870 N PRO A 251 −35.561 −9.160 −64.731 1.00 22.74 N ATOM 1871 CA PRO A 251 −36.336 −8.265 −63.869 1.00 23.00 C ATOM 1872 CB PRO A 251 −37.398 −9.198 −63.251 1.00 22.64 C ATOM 1873 CG PRO A 251 −37.399 −10.422 −64.092 1.00 22.33 C ATOM 1874 CD PRO A 251 −35.990 −10.561 −64.582 1.00 22.62 C ATOM 1875 C PRO A 251 −35.481 −7.650 −62.762 1.00 23.03 C ATOM 1876 O PRO A 251 −35.781 −6.562 −62.270 1.00 24.12 O ATOM 1877 N ILE A 252 −34.418 −8.342 −62.382 1.00 22.49 N ATOM 1878 CA ILE A 252 −33.638 −7.952 −61.222 1.00 22.44 C ATOM 1879 CB ILE A 252 −32.761 −9.136 −60.741 1.00 21.90 C ATOM 1880 CG1 ILE A 252 −32.724 −9.198 −59.219 1.00 21.21 C ATOM 1881 CD1 ILE A 252 −32.179 −10.503 −58.707 1.00 21.87 C ATOM 1882 CG2 ILE A 252 −31.373 −9.125 −61.382 1.00 21.56 C ATOM 1883 C ILE A 252 −32.837 −6.650 −61.455 1.00 23.23 C ATOM 1884 O ILE A 252 −32.334 −6.036 −60.503 1.00 22.56 O ATOM 1885 N ILE A 253 −32.744 −6.222 −62.717 1.00 23.77 N ATOM 1886 CA ILE A 253 −32.165 −4.914 −63.039 1.00 24.15 C ATOM 1887 CB ILE A 253 −30.978 −4.999 −64.043 1.00 24.40 C ATOM 1888 CG1 ILE A 253 −31.471 −5.275 −65.474 1.00 24.83 C ATOM 1889 CD1 ILE A 253 −30.577 −4.711 −66.557 1.00 24.45 C ATOM 1890 CG2 ILE A 253 −29.940 −6.016 −63.577 1.00 23.82 C ATOM 1891 C ILE A 253 −33.213 −3.893 −63.512 1.00 24.41 C ATOM 1892 O ILE A 253 −32.863 −2.798 −63.969 1.00 24.36 O ATOM 1893 N LYS A 254 −34.492 −4.244 −63.385 1.00 25.10 N ATOM 1894 CA LYS A 254 −35.577 −3.327 −63.755 1.00 26.73 C ATOM 1895 CB LYS A 254 −36.947 −3.994 −63.580 1.00 26.05 C ATOM 1896 C LYS A 254 −35.505 −2.043 −62.927 1.00 27.36 C ATOM 1897 O LYS A 254 −35.529 −0.937 −63.467 1.00 27.10 O ATOM 1898 N GLN A 255 −35.347 −2.228 −61.620 1.00 29.17 N ATOM 1899 CA GLN A 255 −35.525 −1.199 −60.598 1.00 30.10 C ATOM 1900 CB GLN A 255 −35.385 −1.847 −59.222 1.00 31.97 C ATOM 1901 CG GLN A 255 −36.239 −1.223 −58.138 1.00 34.09 C ATOM 1902 CD GLN A 255 −37.639 −1.785 −58.119 1.00 37.01 C ATOM 1903 OE1 GLN A 255 −37.927 −2.726 −57.379 1.00 39.24 O ATOM 1904 NE2 GLN A 255 −38.520 −1.223 −58.947 1.00 37.68 N ATOM 1905 C GLN A 255 −34.574 0.001 −60.686 1.00 30.16 C ATOM 1906 O GLN A 255 −34.899 1.093 −60.211 1.00 30.66 O ATOM 1907 N SER A 256 −33.391 −0.183 −61.255 1.00 29.81 N ATOM 1908 CA SER A 256 −32.496 0.963 −61.382 1.00 29.03 C ATOM 1909 CB SER A 256 −31.769 1.240 −60.061 1.00 29.65 C ATOM 1910 OG SER A 256 −31.056 2.476 −60.109 1.00 30.04 O ATOM 1911 C SER A 256 −31.528 0.914 −62.569 1.00 27.68 C ATOM 1912 O SER A 256 −31.697 0.105 −63.491 1.00 27.83 O ATOM 1913 N THR A 257 −30.543 1.809 −62.543 1.00 24.58 N ATOM 1914 CA THR A 257 −29.713 2.068 −63.693 1.00 23.59 C ATOM 1915 CB THR A 257 −29.783 3.552 −64.092 1.00 23.62 C ATOM 1916 OG1 THR A 257 −31.152 3.937 −64.255 1.00 23.90 O ATOM 1917 CBCG2 THR A 257 −29.021 3.821 −65.404 1.00 23.58 C ATOM 1918 C THR A 257 −28.284 1.684 −63.391 1.00 22.84 C ATOM 1919 O THR A 257 −27.747 2.040 −62.345 1.00 23.69 O ATOM 1920 N IRE A 258 −27.668 0.943 −64.302 1.00 21.82 N ATOM 1921 CA IRE A 258 −26.308 0.497 −64.081 1.00 21.03 C ATOM 1922 CB IRE A 258 −26.010 −0.837 −64.763 1.00 20.23 C ATOM 1923 CG1 IRE A 258 −27.005 −1.903 −64.310 1.00 19.80 C ATOM 1924 CD1 IRE A 258 −26.778 −2.390 −62.902 1.00 19.30 C ATOM 1925 CG2 IRE A 258 −24.595 −1.271 −64.439 1.00 20.39 C ATOM 1926 C IRE A 258 −25.353 1.554 −64.575 1.00 21.20 C ATOM 1927 O IRE A 258 −25.384 1.927 −65.749 1.00 21.31 O ATOM 1928 N VAL A 259 −24.502 2.034 −63.670 1.00 20.66 N ATOM 1929 CA VAL A 259 −23.665 3.181 −63.961 1.00 20.05 C ATOM 1930 CB VAL A 259 −24.055 4.397 −63.128 1.00 19.86 C ATOM 1931 CG1 VAL A 259 −25.480 4.805 −63.454 1.00 19.61 C ATOM 1932 CG2 VAL A 259 −23.871 4.107 −61.644 1.00 20.06 C ATOM 1933 C VAL A 259 −22.180 2.930 −63.817 1.00 19.80 C ATOM 1934 O VAL A 259 −21.382 3.675 −64.377 1.00 21.36 O ATOM 1935 N CYS A 260 −21.796 1.900 −63.079 0.50 18.54 N ATOM 1936 CA CYS A 260 −20.403 1.522 −63.056 0.50 17.68 C ATOM 1937 CB CYS A 260 −19.704 2.040 −61.809 0.50 16.71 C ATOM 1938 SG CYS A 260 −20.367 1.381 −60.280 0.50 15.24 S ATOM 1939 C CYS A 260 −20.275 0.034 −63.164 0.50 18.06 C ATOM 1940 O CYS A 260 −21.188 −0.709 −62.840 0.50 17.60 O ATOM 1941 N HIS A 261 −19.127 −0.391 −63.658 1.00 19.49 N ATOM 1942 CA HIS A 261 −18.827 −1.799 −63.838 1.00 20.56 C ATOM 1943 CB HIS A 261 −19.216 −2.248 −65.241 1.00 20.91 C ATOM 1944 CG HIS A 261 −18.238 −1.812 −66.313 1.00 21.44 C ATOM 1945 ND1 HIS A 261 −17.066 −2.456 −66.535 1.00 21.54 N ATOM 1946 CE1 HIS A 261 −16.407 −1.856 −67.537 1.00 21.65 C ATOM 1947 NE2 HIS A 261 −17.157 −0.820 −67.965 1.00 22.55 N ATOM 1948 CD2 HIS A 261 −18.290 −0.765 −67.230 1.00 21.69 C ATOM 1949 C HIS A 261 −17.359 −2.045 −63.615 1.00 20.87 C ATOM 1950 O HIS A 261 −16.582 −1.108 −63.495 1.00 20.12 O ATOM 1951 N ASN A 262 −16.982 −3.322 −63.560 1.00 22.17 N ATOM 1952 CA ASN A 262 −15.587 −3.734 −63.553 1.00 22.63 C ATOM 1953 CB ASN A 262 −14.926 −3.363 −62.238 1.00 24.05 C ATOM 1954 CG ASN A 262 −13.425 −3.412 −62.331 1.00 25.31 C ATOM 1955 OD1 ASN A 262 −12.838 −2.763 −63.208 1.00 26.61 O ATOM 1956 ND2 ASN A 262 −12.787 −4.217 −61.462 1.00 24.75 N ATOM 1957 C ASN A 262 −15.401 −5.225 −63.787 1.00 22.52 C ATOM 1958 O ASN A 262 −16.171 −6.041 −63.274 1.00 23.22 O ATOM 1959 N ARG A 263 −14.357 −5.575 −64.535 1.00 22.27 N ATOM 1960 CA ARG A 263 −14.015 −6.981 −64.810 1.00 22.10 C ATOM 1961 CB ARG A 263 −13.013 −7.049 −65.950 1.00 21.45 C ATOM 1962 CG ARG A 263 −13.027 −8.345 −66.716 1.00 21.94 C ATOM 1963 CD ARG A 263 −11.711 −8.557 −67.437 1.00 22.51 C ATOM 1964 NE ARG A 263 −11.210 −7.331 −68.045 1.00 22.37 N ATOM 1965 CZ ARG A 263 −9.930 −6.995 −68.081 1.00 22.39 C ATOM 1966 NH1 ARG A 263 −9.022 −7.800 −67.536 1.00 23.56 N ATOM 1967 NH2 ARG A 263 −9.559 −5.852 −68.642 1.00 21.93 N ATOM 1968 C ARG A 263 −13.439 −7.710 −63.589 1.00 22.33 C ATOM 1969 O ARG A 263 −12.499 −7.228 −62.953 1.00 22.51 O ATOM 1970 N VAL A 264 −13.997 −8.875 −63.269 1.00 22.87 N ATOM 1971 CA VAL A 264 −13.488 −9.679 −62.152 1.00 23.22 C ATOM 1972 CB VAL A 264 −14.578 −10.590 −61.542 1.00 22.71 C ATOM 1973 CG1 VAL A 264 −13.980 −11.649 −60.625 1.00 23.11 C ATOM 1974 CG2 VAL A 264 −15.559 −9.746 −60.765 1.00 22.14 C ATOM 1975 C VAL A 264 −12.226 −10.455 −62.536 1.00 23.81 C ATOM 1976 O VAL A 264 −11.202 −10.310 −61.897 1.00 24.52 O ATOM 1977 N ASP A 265 −12.284 −11.253 −63.589 1.00 25.28 N ATOM 1978 CA ASP A 265 −11.126 −12.053 −63.978 1.00 26.97 C ATOM 1979 CB ASP A 265 −11.431 −13.536 −63.787 1.00 28.67 C ATOM 1980 CG ASP A 265 −12.866 −13.881 −64.131 1.00 30.59 C ATOM 1981 OD1 ASP A 265 −13.288 −13.601 −65.281 1.00 31.08 O ATOM 1982 OD2 ASP A 265 −13.570 −14.427 −63.246 1.00 31.23 O ATOM 1983 C ASP A 265 −10.679 −11.762 −65.416 1.00 27.09 C ATOM 1984 O ASP A 265 −11.478 −11.279 −66.216 1.00 25.96 O ATOM 1985 N PRO A 266 −9.390 −12.036 −65.737 1.00 27.64 N ATOM 1986 CA PRO A 266 −8.837 −11.839 −67.085 1.00 27.90 C ATOM 1987 CB PRO A 266 −7.487 −12.581 −67.030 1.00 27.75 C ATOM 1988 CG PRO A 266 −7.413 −13.227 −65.673 1.00 26.88 C ATOM 1989 CD PRO A 266 −8.344 −12.466 −64.793 1.00 26.68 C ATOM 1990 C PRO A 266 −9.727 −12.427 −68.177 1.00 28.35 C ATOM 1991 O PRO A 266 −10.073 −11.729 −69.120 1.00 28.99 O ATOM 1992 N ASN A 267 −10.090 −13.700 −68.026 1.00 29.75 N ATOM 1993 CA ASN A 267 −11.121 −14.383 −68.832 1.00 30.88 C ATOM 1994 CB ASN A 267 −11.650 −15.592 −68.036 1.00 34.22 C ATOM 1995 CG ASN A 267 −12.161 −16.723 −68.926 1.00 37.10 C ATOM 1996 OD1 ASN A 267 −12.521 −16.519 −70.095 1.00 38.84 O ATOM 1997 ND2 ASN A 267 −12.199 −17.931 −68.368 1.00 37.27 N ATOM 1998 C ASN A 267 −12.315 −13.514 −69.254 1.00 29.58 C ATOM 1999 O ASN A 267 −12.819 −13.636 −70.365 1.00 28.07 O ATOM 2000 N GLY A 268 −12.771 −12.659 −68.341 1.00 30.47 N ATOM 2001 CA GLY A 268 −13.976 −11.858 −68.534 1.00 30.23 C ATOM 2002 C GLY A 268 −15.241 −12.639 −68.226 1.00 30.13 C ATOM 2003 O GLY A 268 −16.337 −12.207 −68.570 1.00 29.90 O ATOM 2004 N SER A 269 −15.088 −13.799 −67.590 1.00 30.83 N ATOM 2005 CA SER A 269 −16.233 −14.654 −67.226 1.00 32.21 C ATOM 2006 CB SER A 269 −15.771 −15.883 −66.429 1.00 33.78 C ATOM 2007 OG SER A 269 −14.545 −16.391 −66.930 1.00 36.77 O ATOM 2008 C SER A 269 −17.261 −13.884 −66.397 1.00 31.53 C ATOM 2009 O SER A 269 −18.469 −14.001 −66.618 1.00 31.53 O ATOM 2010 N ARG A 270 −16.760 −13.099 −65.447 1.00 29.82 N ATOM 2011 CA ARG A 270 −17.595 −12.364 −64.527 1.00 27.38 C ATOM 2012 CB ARG A 270 −17.397 −12.907 −63.116 1.00 28.98 C ATOM 2013 CG ARG A 270 −17.948 −14.314 −62.904 1.00 30.93 C ATOM 2014 CD ARG A 270 −17.467 −14.918 −61.590 1.00 32.35 C ATOM 2015 NE ARG A 270 −16.005 −14.882 −61.497 1.00 34.54 N ATOM 2016 CZ ARG A 270 −15.270 −15.654 −60.701 1.00 34.35 C ATOM 2017 NH1 ARG A 270 −15.861 −16.547 −59.910 1.00 34.33 N ATOM 2018 NH2 ARG A 270 −13.940 −15.536 −60.706 1.00 33.76 N ATOM 2019 C ARG A 270 −17.303 −10.866 −64.560 1.00 25.26 C ATOM 2020 O ARG A 270 −16.159 −10.447 −64.705 1.00 24.53 O ATOM 2021 N TYR A 271 −18.357 −10.071 −64.424 1.00 23.28 N ATOM 2022 CA TYR A 271 −18.233 −8.634 −64.251 1.00 21.55 C ATOM 2023 CB TYR A 271 −18.785 −7.917 −65.481 1.00 22.00 C ATOM 2024 CG TYR A 271 −17.855 −8.012 −66.664 1.00 22.35 C ATOM 2025 CD1 TYR A 271 −17.912 −9.098 −67.528 1.00 22.24 C ATOM 2026 CE1 TYR A 271 −17.044 −9.198 −68.597 1.00 22.70 C ATOM 2027 CZ TYR A 271 −16.102 −8.213 −68.805 1.00 22.80 C ATOM 2028 OH TYR A 271 −15.237 −8.326 −69.862 1.00 24.17 O ATOM 2029 CE2 TYR A 271 −16.020 −7.125 −67.960 1.00 22.33 C ATOM 2030 CD2 TYR A 271 −16.894 −7.026 −66.900 1.00 22.12 C ATOM 2031 C TYR A 271 −18.981 −8.200 −63.007 1.00 20.26 C ATOM 2032 O TYR A 271 −19.979 −8.810 −62.642 1.00 20.18 O ATOM 2033 N LEU A 272 −18.485 −7.167 −62.336 1.00 19.08 N ATOM 2034 CA LEU A 272 −19.249 −6.519 −61.269 1.00 18.06 C ATOM 2035 CB LEU A 272 −18.339 −6.086 −60.125 1.00 17.47 C ATOM 2036 CG LEU A 272 −17.752 −7.203 −59.262 1.00 17.40 C ATOM 2037 CD1 LEU A 272 −16.629 −6.694 −58.379 1.00 17.33 C ATOM 2038 CD2 LEU A 272 −18.818 −7.871 −58.409 1.00 17.74 C ATOM 2039 C LEU A 272 −19.988 −5.319 −61.852 1.00 17.86 C ATOM 2040 O LEU A 272 −19.447 −4.625 −62.727 1.00 17.49 O ATOM 2041 N LEU A 273 −21.230 −5.097 −61.401 1.00 17.25 N ATOM 2042 CA LEU A 273 −22.055 −3.971 −61.890 1.00 16.33 C ATOM 2043 CB LEU A 273 −23.190 −4.449 −62.787 1.00 15.75 C ATOM 2044 CG LEU A 273 −22.942 −5.353 −63.971 1.00 15.56 C ATOM 2045 CD1 LEU A 273 −24.256 −5.440 −64.705 1.00 15.75 C ATOM 2046 CD2 LEU A 273 −21.875 −4.789 −64.886 1.00 15.88 C ATOM 2047 C LEU A 273 −22.674 −3.199 −60.759 1.00 16.01 C ATOM 2048 O LEU A 273 −23.302 −3.781 −59.877 1.00 16.22 O ATOM 2049 N GLY A 274 −22.547 −1.881 −60.831 1.00 16.08 N ATOM 2050 CA GLY A 274 −23.061 −0.975 −59.805 1.00 16.16 C ATOM 2051 C GLY A 274 −24.246 −0.116 −60.201 1.00 16.15 C ATOM 2052 O GLY A 274 −24.188 −0.686 −61.129 1.00 15.77 O ATOM 2053 N ASP A 275 −25.320 −0.308 −59.453 1.00 17.18 N ATOM 2054 CA ASP A 275 −26.562 0.457 −59.507 1.00 17.84 C ATOM 2055 CB ASP A 275 −29.442 −0.121 −58.412 1.00 18.98 C ATOM 2056 CG ASP A 275 −28.878 0.115 −58.643 1.00 20.70 C ATOM 2057 OD1 ASP A 275 −29.228 1.296 −58.831 1.00 22.80 O ATOM 2058 OD2 ASP A 275 −29.662 −0.868 −58.623 1.00 20.80 O ATOM 2059 C ASP A 275 −26.366 1.936 −59.199 1.00 17.81 C ATOM 2060 O ASP A 275 −25.329 2.335 −58.673 1.00 18.80 O ATOM 2061 N MET A 276 −27.382 2.745 −59.465 0.50 17.44 N ATOM 2062 CA MET A 276 −27.356 4.152 −59.075 0.50 17.27 C ATOM 2063 CB MET A 276 −28.250 4.951 −60.006 0.50 16.36 C ATOM 2064 CG MET A 276 −27.658 6.265 −60.441 0.50 15.70 C ATOM 2065 SD MET A 276 −28.835 7.175 −61.433 0.50 14.81 S ATOM 2066 CE MET A 276 −28.872 6.168 −62.893 0.50 15.21 C ATOM 2067 C MET A 276 −27.814 4.351 −57.631 0.50 17.87 C ATOM 2068 O MET A 276 −27.789 5.456 −57.111 0.50 17.37 O ATOM 2069 N GLU A 277 −28.205 3.257 −56.991 1.00 19.52 N ATOM 2070 CA GLU A 277 −28.971 3.277 −55.748 1.00 20.94 C ATOM 2071 CB GLU A 277 −30.423 2.825 −56.000 1.00 24.45 C ATOM 2072 CG GLU A 277 −31.305 3.821 −56.748 1.00 29.67 C ATOM 2073 CD GLU A 277 −32.795 3.719 −56.383 1.00 34.13 C ATOM 2074 OE1 GLU A 277 −33.142 3.055 −55.373 1.00 36.28 O ATOM 2075 OE2 GLU A 277 −33.632 4.328 −57.099 1.00 37.15 O ATOM 2076 C GLU A 277 −28.367 2.353 −54.692 1.00 19.99 C ATOM 2077 O GLU A 277 −28.956 2.168 −53.624 1.00 19.90 O ATOM 2078 N GLY A 278 −27.222 1.739 −54.995 1.00 18.39 N ATOM 2079 CA GLY A 278 −26.498 0.959 −53.991 1.00 16.63 C ATOM 2080 C GLY A 278 −26.391 −0.523 −54.274 1.00 15.66 C ATOM 2081 O GLY A 278 −25.657 −1.236 −53.589 1.00 15.65 O ATOM 2082 N ARG A 279 −27.114 −0.994 −55.282 0.50 14.73 N ATOM 2083 CA ARG A 279 −27.097 −2.404 −55.601 0.50 13.97 C ATOM 2084 CB ARG A 279 −28.327 −2.820 −56.415 0.50 13.82 C ATOM 2085 CG ARG A 279 −29.642 −2.758 −55.659 0.50 13.31 C ATOM 2086 CD ARG A 279 −30.799 −3.020 −56.603 0.50 13.21 C ATOM 2087 NE ARG A 279 −32.082 −2.574 −56.064 0.50 13.02 N ATOM 2088 CZ ARG A 279 −32.591 −1.360 −56.242 0.50 12.74 C ATOM 2089 NH1 ARG A 279 −31.921 −0.453 −56.938 0.50 12.79 N ATOM 2090 NH2 ARG A 279 −33.763 −1.050 −55.715 0.50 12.61 N ATOM 2091 C ARG A 279 −25.822 −2.776 −56.329 0.50 13.57 C ATOM 2092 O ARG A 279 −25.312 −2.040 −57.165 0.50 12.94 O ATOM 2093 N LEU A 280 −25.307 −3.931 −55.952 1.00 13.86 N ATOM 2094 CA LEU A 280 −24.160 −4.547 −56.583 1.00 14.00 C ATOM 2095 CB LEU A 280 −23.080 −4.848 −55.543 1.00 13.58 C ATOM 2096 CG LEU A 280 −21.725 −5.295 −56.080 1.00 13.40 C ATOM 2097 CD1 LEU A 280 −21.062 −4.163 −56.853 1.00 13.43 C ATOM 2098 CD2 LEU A 280 −20.840 −5.793 −54.948 1.00 13.17 C ATOM 2099 C LEU A 280 −24.617 −5.837 −57.228 1.00 14.36 C ATOM 2100 O LEU A 280 −25.209 −6.696 −56.566 1.00 14.01 O ATOM 2101 N PHE A 281 −24.358 −5.956 −58.526 1.00 15.23 N ATOM 2102 CA PHE A 281 −24.741 −7.135 −59.286 1.00 16.35 C ATOM 2103 CB PHE A 281 −25.488 −6.722 −60.539 1.00 16.26 C ATOM 2104 CG PHE A 281 −26.836 −6.162 −60.277 1.00 16.10 C ATOM 2105 CD1 PHE A 281 −27.918 −7.009 −60.076 1.00 15.93 C ATOM 2106 CE1 PHE A 281 −29.169 −6.490 −59.839 1.00 16.55 C ATOM 2107 CZ PHE A 281 −29.347 −5.104 −59.806 1.00 16.87 C ATOM 2108 CE2 PHE A 281 −28.271 −4.252 −60.001 1.00 16.07 C ATOM 2109 CD2 PHE A 281 −27.026 −4.784 −60.240 1.00 15.94 C ATOM 2110 C PHE A 281 −23.524 −7.890 −59.734 1.00 17.57 C ATOM 2111 O PHE A 281 −22.437 −7.307 −59.823 1.00 18.48 O ATOM 2112 N MET A 282 −23.699 −9.174 −60.041 1.00 18.62 N ATOM 2113 CA MET A 282 −22.721 −9.861 −60.863 1.00 20.18 C ATOM 2114 CB MET A 282 −22.088 −11.034 −60.157 1.00 22.06 C ATOM 2115 CG MET A 282 −21.075 −11.740 −61.042 1.00 24.55 C ATOM 2116 SD MET A 282 −19.486 −11.891 −60.216 1.00 29.62 S ATOM 2117 CE MET A 282 −19.873 −13.232 −59.071 1.00 28.21 C ATOM 2118 C MET A 282 −23.290 −10.316 −62.190 1.00 20.42 C ATOM 2119 O LEU A 283 −24.315 −11.003 −62.235 1.00 21.04 O ATOM 2120 N LEU A 283 −22.603 −9.930 −63.263 1.00 19.87 N ATOM 2121 CA LEU A 283 −22.898 −10.410 −64.590 1.00 19.74 C ATOM 2122 CB LEU A 283 −22.758 −9.278 −65.601 1.00 19.63 C ATOM 2123 CG LEU A 283 −22.985 −9.560 −67.084 1.00 19.24 C ATOM 2124 CD1 LEU A 283 −24.392 −10.071 −67.347 1.00 18.86 C ATOM 2125 CD2 LEU A 283 −22.696 −8.295 −67.876 1.00 18.90 C ATOM 2126 C LEU A 283 −21.947 −11.546 −64.920 1.00 20.30 C ATOM 2127 O LEU A 283 −20.753 −11.467 −64.632 1.00 20.06 O ATOM 2128 N LEU A 284 −22.507 −12.602 −65.515 1.00 21.15 N ATOM 2129 CA LEU A 284 −21.793 −13.828 −65.859 1.00 21.30 C ATOM 2130 CB LEU A 284 −22.350 −14.990 −65.041 1.00 20.57 C ATOM 2131 CG LEU A 284 −22.105 −14.944 −63.529 1.00 20.60 C ATOM 2132 CD1 LEU A 284 −23.413 −15.016 −62.770 1.00 20.78 C ATOM 2133 CD2 LEU A 284 −21.160 −16.039 −63.055 1.00 20.68 C ATOM 2134 C LEU A 284 −21.965 −14.123 −67.349 1.00 22.46 C ATOM 2135 O LEU A 284 −23.072 −13.984 −67.890 1.00 22.39 O ATOM 2136 N LEU A 285 −20.871 −14.510 −68.013 1.00 23.62 N ATOM 2137 CA LEU A 285 −20.928 −14.980 −69.403 1.00 24.40 C ATOM 2138 CB LEU A 285 −19.792 −14.403 −70.250 1.00 24.24 C ATOM 2139 CG LEU A 285 −19.415 −12.916 −70.287 1.00 24.28 C ATOM 2140 CD1 LEU A 285 −18.752 −12.604 −71.620 1.00 24.38 C ATOM 2141 CD2 LEU A 285 −20.599 −11.995 −70.064 1.00 23.90 C ATOM 2142 C LEU A 285 −20.820 −16.489 −69.389 1.00 26.19 C ATOM 2143 O LEU A 285 −19.840 −17.036 −68.898 1.00 27.66 O ATOM 2144 N GLU A 286 −21.826 −17.170 −69.916 1.00 28.48 N ATOM 2145 CA GLU A 286 −21.875 −18.617 −69.799 1.00 30.21 C ATOM 2146 CB GLU A 286 −23.253 −19.069 −69.324 1.00 31.60 C ATOM 2147 CG GLU A 286 −23.807 −18.214 −68.197 1.00 33.06 C ATOM 2148 CD GLU A 286 −24.730 −18.967 −67.247 1.00 36.91 C ATOM 2149 OE1 GLU A 286 −25.656 −19.697 −67.707 1.00 37.26 O ATOM 2150 OE2 GLU A 286 −24.535 −18.803 −66.018 1.00 39.32 O ATOM 2151 C GLU A 286 −21.463 −19.285 −71.110 1.00 31.63 C ATOM 2152 O GLU A 286 −21.940 −18.910 −72.193 1.00 30.47 O ATOM 2153 N LYS A 287 −20.560 −20.266 −70.992 1.00 33.33 N ATOM 2154 CA LYS A 287 −19.890 −20.902 −72.144 1.00 33.50 C ATOM 2155 CB LYS A 287 −18.358 −20.882 −71.975 1.00 34.14 C ATOM 2156 CG LYS A 287 −17.869 −21.006 −70.538 1.00 36.29 C ATOM 2157 CD LYS A 287 −16.355 −20.876 −70.452 1.00 38.33 C ATOM 2158 CE LYS A 287 −15.930 −19.829 −69.421 1.00 40.74 C ATOM 2159 NZ LYS A 287 −16.037 −20.276 −68.000 1.00 40.62 N ATOM 2160 C LYS A 287 −20.377 −22.319 −72.448 1.00 31.91 C ATOM 2161 O LYS A 287 −21.099 −22.919 −71.662 1.00 30.94 O ATOM 2162 N THR A 296 −18.443 −21.919 −77.420 1.00 43.82 N ATOM 2163 CA THR A 296 −18.117 −20.643 −76.783 1.00 46.23 C ATOM 2164 CB THR A 296 −17.490 −19.636 −77.781 1.00 49.44 C ATOM 2165 OG1 THR A 296 −18.479 −19.195 −78.729 1.00 49.39 O ATOM 2166 CG2 THR A 296 −16.282 −20.268 −78.505 1.00 49.45 C ATOM 2167 C THR A 296 −19.326 −20.022 −76.064 1.00 43.76 C ATOM 2168 O THR A 296 −20.117 −20.745 −75.467 1.00 45.08 O ATOM 2169 N LEU A 297 −19.467 −18.695 −76.133 1.00 41.47 N ATOM 2170 CA LEU A 297 −20.452 −17.954 −75.321 1.00 40.13 C ATOM 2171 CB LEU A 297 −20.137 −16.453 −75.330 1.00 40.21 C ATOM 2172 CG LEU A 297 −21.148 −15.489 −74.690 1.00 41.40 C ATOM 2173 CD1 LEU A 297 −21.487 −15.852 −73.249 1.00 41.17 C ATOM 2174 CD2 LEU A 297 −20.618 −14.068 −74.757 1.00 41.99 C ATOM 2175 C LEU A 297 −21.927 −18.192 −75.685 1.00 37.84 C ATOM 2176 O LEU A 297 −22.367 −17.845 −76.777 1.00 36.20 O ATOM 2177 N LYS A 298 −22.687 −18.746 −74.738 1.00 36.28 N ATOM 2178 CA LYS A 298 −24.066 −19.156 −75.008 1.00 35.16 C ATOM 2179 CB LYS A 298 −24.262 −20.653 −74.765 1.00 34.30 C ATOM 2180 CG LYS A 298 −25.419 −21.217 −75.564 1.00 33.96 C ATOM 2181 CD LYS A 298 −25.712 −22.662 −75.213 1.00 36.09 C ATOM 2182 CE LYS A 298 −27.136 −23.026 −75.618 1.00 37.68 C ATOM 2183 NZ LYS A 298 −27.512 −22.463 −76.949 1.00 37.27 N ATOM 2184 C LYS A 298 −25.161 −18.363 −74.292 1.00 34.24 C ATOM 2185 O LYS A 298 −26.277 −18.275 −74.797 1.00 35.34 O ATOM 2186 N ASP A 299 −24.867 −17.792 −73.129 1.00 32.83 N ATOM 2187 CA ASP A 299 −25.889 −17.018 −72.426 1.00 30.99 C ATOM 2188 CB ASP A 299 −26.801 −17.951 −71.635 1.00 32.92 C ATOM 2189 CG ASP A 299 −28.208 −17.407 −71.495 1.00 35.16 C ATOM 2190 OD1 ASP A 299 −28.437 −16.215 −71.832 1.00 35.55 O ATOM 2191 OD2 ASP A 299 −29.090 −18.177 −71.047 1.00 36.78 O ATOM 2192 C ASP A 299 −25.319 −15.955 −71.507 1.00 28.47 C ATOM 2193 O ASP A 299 −24.123 −15.956 −71.234 1.00 28.56 O ATOM 2194 N LEU A 300 −26.185 −15.047 −71.04 1.00 25.53 N ATOM 2195 CA LEU A 300 −25.854 −14.114 −69.953 1.00 23.33 C ATOM 2196 CB LEU A 300 −25.870 −12.669 −70.447 1.00 23.08 C ATOM 2197 CG LEU A 300 −25.277 −12.383 −71.826 1.00 23.51 C ATOM 2198 CD1 LEU A 300 −25.648 −10.986 −72.294 1.00 23.70 C ATOM 2199 CD2 LEU A 300 −23.772 −12.581 −71.843 1.00 21.51 C ATOM 2200 C LEU A 300 −26.811 −14.261 −68.761 1.00 21.81 C ATOM 2201 O LEU A 300 −28.010 −14.497 −68.949 1.00 21.78 O ATOM 2202 N ARG A 301 −26.272 −14.123 −67.543 1.00 19.96 N ATOM 2203 CA ARG A 301 −27.067 −14.159 −66.295 1.00 18.46 C ATOM 2204 CB ARG A 301 −26.957 −15.536 −65.617 1.00 17.37 C ATOM 2205 C ARG A 301 −26.644 −13.055 −65.308 1.00 17.47 C ATOM 2206 O ARG A 301 −25.460 −12.802 −65.120 1.00 17.41 O ATOM 2207 N VAL A 302 −27.608 −12.405 −64.675 1.00 16.69 N ATOM 2208 CA VAL A 302 −27.286 −11.441 −63.621 1.00 16.35 C ATOM 2209 CB VAL A 302 −27.999 −10.090 −63.822 1.00 16.15 C ATOM 2210 CG1 VAL A 302 −27.298 −9.009 −63.025 1.00 16.08 C ATOM 2211 CG2 VAL A 302 −28.031 −9.695 −65.286 1.00 16.38 C ATOM 2212 C VAL A 302 −27.670 −12.001 −62.253 1.00 16.48 C ATOM 2213 O VAL A 302 −28.676 −12.702 −62.124 1.00 16.24 O ATOM 2214 N GLU A 303 −26.865 −11.696 −61.235 1.00 16.67 N ATOM 2215 CA GLU A 303 −27.167 −12.086 −59.858 1.00 16.99 C ATOM 2216 CB GLU A 303 −26.145 −13.116 −59.353 1.00 18.23 C ATOM 2217 CG GLU A 303 −26.328 −14.554 −59.843 1.00 19.73 C ATOM 2218 CD GLU A 303 −25.203 −15.492 −59.378 1.00 20.69 C ATOM 2219 OE1 GLU A 303 −24.405 −15.078 −58.493 1.00 20.78 O ATOM 2220 OE2 GLU A 303 −25.119 −16.647 −59.891 1.00 20.86 O ATOM 2221 C GLU A 303 −27.105 −10.842 −58.977 1.00 16.49 C ATOM 2222 O GLU A 303 −26.185 −10.046 −59.135 1.00 17.08 O ATOM 2223 N LEU A 304 −28.057 −10.680 −58.051 1.00 15.41 N ATOM 2224 CA LEU A 304 −28.024 −9.548 −57.102 1.00 14.71 C ATOM 2225 CB LEU A 304 −29.445 −9.063 −56.731 1.00 14.17 C ATOM 2226 CG LEU A 304 −29.630 −8.008 −55.618 1.00 13.57 C ATOM 2227 CD1 LEU A 304 −28.831 −6.756 −55.888 1.00 13.42 C ATOM 2228 CD2 LEU A 304 −31.090 −7.648 −55.411 1.00 13.48 C ATOM 2229 C LEU A 304 −27.176 −9.799 −55.847 1.00 14.46 C ATOM 2230 O LEU A 304 −27.613 −10.434 −54.900 1.00 14.46 O ATOM 2231 N LEU A 305 −25.972 −9.257 −55.827 1.00 14.77 N ATOM 2232 CA LEU A 305 −25.075 −9.485 −54.697 1.00 15.38 C ATOM 2233 CB LEU A 305 −23.642 −9.085 −55.047 1.00 15.05 C ATOM 2234 CG LEU A 305 −23.126 −9.731 −56.341 1.00 15.28 C ATOM 2235 CD1 LEU A 305 −21.838 −9.060 −56.821 1.00 15.56 C ATOM 2236 CD2 LEU A 305 −22.943 −11.235 −56.214 1.00 14.98 C ATOM 2237 C LEU A 305 −25.521 −8.836 −53.387 1.00 15.94 C ATOM 2238 O LEU A 305 −25.290 −9.391 −52.322 1.00 16.03 O ATOM 2239 N GLY A 306 −26.154 −7.666 −53.468 1.00 16.91 N ATOM 2240 CA GLY A 306 −26.554 −6.917 −52.276 1.00 17.48 C ATOM 2241 C GLY A 306 −26.270 −5.422 −52.344 1.00 18.55 C ATOM 2242 O GLU A 306 −26.099 −4.850 −53.425 1.00 18.02 O ATOM 2243 N GLU A 307 −26.211 −4.799 −51.167 1.00 19.85 N ATOM 2244 CA GLU A 307 −26.119 −3.346 −51.022 1.00 20.40 C ATOM 2245 CB GLU A 307 −27.180 −2.873 −50.030 1.00 22.91 C ATOM 2246 CG GLU A 307 −27.523 −1.388 −50.056 1.00 25.66 C ATOM 2247 CD GLU A 307 −28.139 −0.909 −48.732 1.00 27.80 C ATOM 2248 OE1 GLU A 307 −29.256 −1.366 −48.374 1.00 27.85 O ATOM 2249 OE2 GLU A 307 −27.498 −0.073 −48.041 1.00 29.67 O ATOM 2250 C GLU A 307 −24.734 −2.940 −50.529 1.00 20.06 C ATOM 2251 O GLU A 307 −24.168 −3.561 −49.619 1.00 20.24 O ATOM 2252 N THR A 308 −24.176 −1.918 −51.165 1.00 18.95 N ATOM 2253 CA THR A 308 −22.916 −1.328 −50.745 1.00 17.93 C ATOM 2254 CB THR A 308 −21.799 −1.582 −51.769 1.00 17.91 C ATOM 2255 OG1 THR A 308 −22.196 −1.068 −53.041 1.00 18.40 O ATOM 2256 CG2 THR A 308 −21.510 −3.053 −51.908 1.00 17.84 C ATOM 2257 C THR A 308 −23.185 0.150 −50.695 1.00 17.45 C ATOM 2258 O THR A 308 −24.325 0.568 −50.886 1.00 17.68 O ATOM 2259 N SER A 309 −22.161 0.954 −50.447 1.00 16.65 N ATOM 2260 CA SER A 309 −22.315 2.381 −50.637 1.00 16.44 C ATOM 2261 CB SER A 309 −21.002 3.107 −50.366 1.00 16.86 C ATOM 2262 OG SER A 309 −20.604 3.008 −49.013 1.00 17.45 O ATOM 2263 C SER A 309 −22.692 2.589 −52.097 1.00 16.11 C ATOM 2264 O SER A 309 −22.323 1.787 −52.958 1.00 16.44 O ATOM 2265 N ILE A 310 −23.420 3.661 −52.378 1.00 15.08 N ATOM 2266 CA ILE A 310 −23.714 4.035 −53.740 1.00 14.24 C ATOM 2267 CB ILE A 310 −24.524 5.336 −53.780 1.00 13.93 C ATOM 2268 CG1 ILE A 310 −25.882 5.109 −53.120 1.00 13.85 C ATOM 2269 CD1 ILE A 310 −26.638 6.375 −52.811 1.00 14.15 C ATOM 2270 CG2 ILE A 310 −24.708 5.811 −55.206 1.00 13.76 C ATOM 2271 C ILE A 310 −22.392 4.192 −54.454 1.00 14.19 C ATOM 2272 O ILE A 310 −21.600 5.058 −54.111 1.00 14.14 O ATOM 2273 N ALA A 311 −22.137 3.312 −55.415 1.00 14.61 N ATOM 2274 CA ALA A 311 −20.820 3.221 −56.052 1.00 15.20 C ATOM 2275 CB ALA A 311 −20.561 1.809 −56.553 1.00 14.73 C ATOM 2276 C ALA A 311 −20.633 4.230 −57.177 1.00 15.89 C ATOM 2277 O ALA A 311 −21.555 4.509 −57.942 1.00 16.39 O ATOM 2278 N GLU A 312 −19.436 4.785 −57.257 1.00 16.71 N ATOM 2279 CA GLU A 312 −19.065 5.649 −58.355 1.00 17.97 C ATOM 2280 CB GLU A 312 −18.323 6.882 −57.825 1.00 19.13 C ATOM 2281 CG GLU A 312 −17.526 7.668 −58.862 1.00 21.30 C ATOM 2282 CD GLU A 312 −18.388 8.473 −59.854 1.00 24.28 C ATOM 2283 OE1 GLU A 312 −17.809 8.986 −60.860 1.00 25.05 O ATOM 2284 OE2 GLU A 312 −19.634 8.603 −59.636 1.00 25.16 O ATOM 2285 C GLU A 312 −18.159 4.823 −59.239 1.00 18.29 C ATOM 2286 O GLU A 312 −18.220 4.906 −60.472 1.00 18.39 O ATOM 2287 N CYS A 313 −17.318 4.014 −58.590 1.00 18.05 N ATOM 2288 CA CYS A 313 −16.394 3.149 −59.278 1.00 17.57 C ATOM 2289 CB CYS A 313 −15.108 3.922 −59.580 1.00 18.32 C ATOM 2290 SG CYS A 313 −13.988 4.192 −58.192 1.00 20.08 S ATOM 2291 C CYS A 313 −16.136 1.862 −58.483 1.00 17.19 C ATOM 2292 O CYS A 313 −16.161 1.875 −57.261 1.00 17.58 O ATOM 2293 N LEU A 314 −15.911 0.749 −59.180 1.00 16.98 N ATOM 2294 CA LEU A 314 −15.615 −0.540 −58.534 1.00 16.94 C ATOM 2295 CB LEU A 314 −16.702 −1.567 −58.834 1.00 16.38 C ATOM 2296 CG LEU A 314 −18.144 −1.225 −58.482 1.00 16.35 C ATOM 2297 CD1 LEU A 314 −19.094 −2.058 −59.317 1.00 16.20 C ATOM 2298 CD2 LEU A 314 −18.411 −1.427 −56.997 1.00 16.48 C ATOM 2299 C LEU A 314 −14.305 −1.120 −59.008 1.00 17.76 C ATOM 2300 O LEU A 314 −13.966 −1.055 −60.192 1.00 17.93 O ATOM 2301 N THR A 315 −13.570 −1.714 −58.084 1.00 18.98 N ATOM 2302 CA THR A 315 −12.379 −2.477 −58.445 1.00 19.73 C ATOM 2303 CB THR A 315 −11.073 −1.718 −58.147 1.00 20.57 C ATOM 2304 OG1 THR A 315 −11.262 −0.313 −58.368 1.00 22.30 O ATOM 2305 CG2 THR A 315 −9.968 −2.217 −59.054 1.00 21.13 C ATOM 2306 C THR A 315 −12.367 −3.783 −57.680 1.00 19.65 C ATOM 2307 O THR A 315 −12.553 −3.799 −56.462 1.00 19.98 O ATOM 2308 N TYR A 316 −12.185 −4.881 −58.399 1.00 19.77 N ATOM 2309 CA TYR A 316 −11.939 −6.150 −57.759 1.00 20.09 C ATOM 2310 CB TYR A 316 −12.334 −7.311 −58.665 1.00 20.79 C ATOM 2311 CG TYR A 316 −12.034 −8.660 −58.061 1.00 20.79 C ATOM 2312 CD1 TYR A 316 −12.829 −9.169 −57.035 1.00 20.90 C ATOM 2313 CE1 TYR A 316 −12.565 −10.405 −56.473 1.00 20.88 C ATOM 2314 CZ TYR A 316 −11.490 −11.138 −56.923 1.00 20.85 C ATOM 2315 OH TYR A 316 −11.233 −12.346 −56.342 1.00 21.09 O ATOM 2316 CE2 TYR A 316 −10.673 −10.654 −57.934 1.00 20.84 C ATOM 2317 CD2 TYR A 316 −10.949 −9.421 −58.501 1.00 20.46 C ATOM 2318 C TYR A 316 −10.470 −6.220 −57.472 1.00 20.16 C ATOM 2319 O TYR A 316 −9.646 −6.010 −58.367 1.00 20.18 O ATOM 2320 N LEU A 317 −10.136 −6.523 −56.228 1.00 20.50 N ATOM 2321 CA LEU A 317 −8.741 −6.643 −55.835 1.00 21.67 C ATOM 2322 CB LEU A 317 −8.501 −6.001 −54.461 1.00 19.96 C ATOM 2323 CG LEU A 317 −9.064 −4.580 −54.298 1.00 18.32 C ATOM 2324 CD1 LEU A 317 −8.866 −4.055 −52.887 1.00 17.64 C ATOM 2325 CD2 LEU A 317 −8.437 −3.646 −55.306 1.00 18.01 C ATOM 2326 C LEU A 317 −8.287 −8.107 −55.893 1.00 23.97 C ATOM 2327 O LEU A 317 −7.634 −8.513 −56.853 1.00 25.60 O ATOM 2328 N ASP A 318 −8.673 −8.907 −54.905 1.00 26.15 N ATOM 2329 CA ASP A 318 −8.175 −10.273 −54.786 1.00 27.89 C ATOM 2330 CB ASP A 318 −6.651 −10.255 −54.677 1.00 31.85 C ATOM 2331 CG ASP A 318 −6.033 −11.622 −54.873 1.00 36.21 C ATOM 2332 OD1 ASP A 318 −6.750 −12.542 −55.336 1.00 38.00 O ATOM 2333 OD2 ASP A 318 −4.823 −11.771 −54.566 1.00 39.12 O ATOM 2334 C ASP A 318 −8.749 −10.962 −53.559 1.00 27.16 C ATOM 2335 O ASP A 318 −9.141 −10.308 −52.587 1.00 27.14 O ATOM 2336 N ASN A 319 −8.769 −12.289 −53.590 1.00 26.03 N ATOM 2337 CA ASN A 319 −9.372 −13.074 −52.513 1.00 25.13 C ATOM 2338 CB ASN A 319 −8.481 −13.075 −51.247 1.00 24.82 C ATOM 2339 C ASN A 319 −10.791 −12.562 −52.235 1.00 23.65 C ATOM 2340 O ASN A 319 −11.197 −12.361 −51.086 1.00 23.29 O ATOM 2341 N GLY A 320 −11.524 −12.325 −53.320 1.00 22.51 N ATOM 2342 CA GLY A 320 −11.915 −11.89 −53.243 1.00 22.03 C ATOM 2343 C GLY A 320 −13.154 −10.608 −52.479 1.00 21.70 C ATOM 2344 O GLY A 320 −14.229 −10.423 −51.882 1.00 22.19 O ATOM 2345 N VAL A 321 −12.147 −9.727 −52.471 1.00 20.25 N ATOM 2346 CA VAL A 321 −12.282 −8.404 −51.869 1.00 18.77 C ATOM 2347 CB VAL A 321 −11.084 −8.040 −50.968 1.00 18.61 C ATOM 2348 CG1 VAL A 321 −11.092 −6.556 −50.601 1.00 18.45 C ATOM 2349 CG2 VAL A 321 −11.112 −8.886 −49.709 1.00 18.27 C ATOM 2350 C VAL A 321 −12.487 −7.384 −52.971 1.00 17.81 C ATOM 2351 O VAL A 321 −11.892 −7.486 −54.035 1.00 18.14 O ATOM 2352 N VAL A 322 −13.366 −6.427 −52.722 1.00 16.91 N ATOM 2353 CA VAL A 322 −13.731 −5.444 −53.720 1.00 16.27 C ATOM 2354 CB VAL A 322 −15.135 −5.745 −54.302 1.00 16.48 C ATOM 2355 CG1 VAL A 322 −15.612 −4.612 −55.196 1.00 16.59 C ATOM 2356 CG2 VAL A 322 −15.118 −7.039 −55.081 1.00 16.62 C ATOM 2357 C VAL A 322 −13.712 −4.045 −53.110 1.00 15.59 C ATOM 2358 O VAL A 322 −14.265 −3.822 −52.007 1.00 15.25 O ATOM 2359 N PHE A 323 −13.081 −3.112 −53.828 1.00 14.63 N ATOM 2360 CA PHE A 323 −13.120 −1.696 −53.462 1.00 13.97 C ATOM 2361 CB PHE A 323 −11.805 −0.992 −53.787 1.00 13.44 C ATOM 2362 CG PHE A 323 −11.804 0.474 −53.439 1.00 13.46 C ATOM 2363 CD1 PHE A 323 −11.653 0.892 −52.126 1.00 13.22 C ATOM 2364 CE1 PHE A 323 −11.650 2.235 −51.806 1.00 13.00 C ATOM 2365 CZ PHE A 323 −11.797 3.184 −52.796 1.00 13.00 C ATOM 2366 CE2 PHE A 323 −11.932 2.793 −54.111 1.00 13.28 C ATOM 2367 CD2 PHE A 323 −11.942 1.444 −54.431 1.00 13.65 C ATOM 2368 C PHE A 323 −14.281 −0.975 −54.139 1.00 13.78 C ATOM 2369 O PHE A 323 −14.350 −0.896 −55.375 1.00 13.77 O ATOM 2370 N VAL A 324 −15.187 −0.451 −53.311 1.00 13.70 N ATOM 2371 CA VAL A 324 −16.321 0.344 −53.763 1.00 13.58 C ATOM 2372 CB VAL A 324 −17.598 −0.024 −53.006 1.00 13.44 C ATOM 2373 CG1 VAL A 324 −18.720 0.917 −53.386 1.00 13.72 C ATOM 2374 CG2 VAL A 324 −17.999 −1.450 −53.309 1.00 13.60 C ATOM 2375 C VAL A 324 −15.977 1.795 −53.488 1.00 13.87 C ATOM 2376 O VAL A 324 −15.890 2.220 −52.326 1.00 13.82 O ATOM 2377 N GLY A 325 −15.728 2.536 −54.566 1.00 14.08 N ATOM 2378 CA GLY A 325 −15.343 3.932 −54.484 1.00 14.00 C ATOM 2379 C GLY A 325 −16.615 4.731 −54.515 1.00 14.50 C ATOM 2380 O GLY A 325 −17.416 4.593 −55.447 1.00 14.85 O ATOM 2381 N SER A 326 −16.823 5.554 −53.492 1.00 14.50 N ATOM 2382 CA SER A 326 −18.060 6.311 −53.389 1.00 14.64 C ATOM 2383 CB SER A 326 −18.747 6.006 −52.073 1.00 14.39 C ATOM 2384 OG SER A 326 −20.051 6.535 −52.070 1.00 14.44 O ATOM 2385 C SER A 326 −17.851 7.811 −53.530 1.00 14.80 C ATOM 2386 O SER A 326 −16.771 8.322 −53.260 1.00 15.29 O ATOM 2387 N ARG A 327 −18.888 8.512 −53.969 1.00 14.73 N ATOM 2388 CA ARG A 327 −18.875 9.963 −53.941 1.00 14.68 C ATOM 2389 CB ARG A 327 −19.061 10.558 −55.329 1.00 15.01 C ATOM 2390 CG ARG A 327 −17.748 11.016 −55.899 1.00 15.79 C ATOM 2391 CD ARG A 327 −17.781 11.105 −57.410 1.00 17.16 C ATOM 2392 NE ARG A 327 −18.280 12.397 −57.906 1.00 18.54 N ATOM 2393 CZ ARG A 327 −17.872 13.595 −57.482 1.00 17.99 C ATOM 2394 NH1 ARG A 327 −16.986 13.695 −56.510 1.00 18.16 N ATOM 2395 NH2 ARG A 327 −18.385 14.691 −58.006 1.00 17.81 N ATOM 2396 C ARG A 327 −19.933 10.470 −53.017 1.00 14.29 C ATOM 2397 O ARG A 327 −19.716 11.434 −52.302 1.00 14.55 O ATOM 2398 N LEU A 328 −21.078 9.805 −53.021 1.00 14.01 N ATOM 2399 CA LEU A 328 −22.204 10.225 −52.201 1.00 13.71 C ATOM 2400 CB LEU A 328 −23.534 9.810 −52.832 1.00 13.67 C ATOM 2401 CG LEU A 328 −23.693 10.221 −54.301 1.00 14.02 C ATOM 2402 CD1 LEU A 328 −25.074 9.882 −54.853 1.00 13.89 C ATOM 2403 CD2 LEU A 328 −23.399 11.708 −54.460 1.00 14.03 C ATOM 2404 C LEU A 328 −22.117 9.710 −50.776 1.00 13.53 C ATOM 2405 O LEU A 328 −22.897 10.136 −49.938 1.00 13.68 O ATOM 2406 N GLY A 329 −21.171 8.812 −50.495 1.00 12.98 N ATOM 2407 CA GLY A 329 −21.106 8.171 −49.188 1.00 12.98 C ATOM 2408 C GLY A 329 −19.710 7.731 −48.842 1.00 13.02 C ATOM 2409 O GLY A 329 −18.769 8.147 −49.477 1.00 13.63 O ATOM 2410 N ASP A 330 −19.564 6.894 −47.821 1.00 12.96 N ATOM 2411 CA ASP A 330 −18.257 6.359 −47.505 1.00 13.03 C ATOM 2412 CB ASP A 330 −18.269 5.626 −46.155 1.00 13.25 C ATOM 2413 CG ASP A 330 −18.316 6.566 −44.948 1.00 13.38 C ATOM 2414 OD1 ASP A 330 −18.136 7.806 −45.065 1.00 13.30 O ATOM 2415 OD2 ASP A 330 −18.527 6.030 −43.847 1.00 13.66 O ATOM 2416 C ASP A 330 −17.873 5.374 −48.582 1.00 13.02 C ATOM 2417 O ASP A 330 −18.713 4.622 −49.055 1.00 12.92 O ATOM 2418 N SER A 331 −16.600 5.358 −48.954 1.00 13.27 N ATOM 2419 CA SER A 331 −16.090 4.295 −49.808 1.00 13.58 C ATOM 2420 CB SER A 331 −14.830 4.752 −50.511 1.00 13.68 C ATOM 2421 OG SER A 331 −15.157 5.797 −51.414 1.00 13.99 O ATOM 2422 C SER A 331 −15.849 3.052 −48.974 1.00 13.79 C ATOM 2423 O SER A 331 −15.696 3.145 −47.762 1.00 14.01 O ATOM 2424 N GLN A 332 −15.840 1.882 −49.603 1.00 14.16 N ATOM 2425 CA GLN A 332 −15.766 0.626 −48.828 1.00 14.46 C ATOM 2426 CB GLN A 332 −17.122 −0.070 −48.835 1.00 14.26 C ATOM 2427 CG GLN A 332 −18.223 0.650 −48.111 1.00 14.15 C ATOM 2428 CD GLN A 332 −19.560 0.043 −48.430 1.00 14.06 C ATOM 2429 OE1 GLN A 332 −19.879 −0.191 −49.589 1.00 13.97 O ATOM 2430 NE2 GLN A 332 −20.357 −0.212 −47.402 1.00 14.25 N ATOM 2431 C GLN A 332 −14.736 −0.401 −49.288 1.00 14.57 C ATOM 2432 O GLN A 332 −14.244 −0.361 −50.402 1.00 14.57 O ATOM 2433 N LEU A 333 −14.448 −1.345 −48.410 1.00 15.23 N ATOM 2434 CA LEU A 333 −13.960 −2.640 −48.834 1.00 16.21 C ATOM 2435 CB LEU A 333 −12.660 −3.001 −48.109 1.00 15.81 C ATOM 2436 CG LEU A 333 −11.417 −2.272 −48.602 1.00 15.01 C ATOM 2437 CD1 LEU A 333 −10.214 −2.659 −47.772 1.00 14.79 C ATOM 2438 CD2 LEU A 333 −11.174 −2.583 −50.061 1.00 14.97 C ATOM 2439 C LEU A 333 −15.045 −3.679 −48.560 1.00 17.14 C ATOM 2440 O LEU A 333 −15.527 −3.804 −47.438 1.00 17.36 O ATOM 2441 N VAL A 334 −15.454 −4.402 −49.594 1.00 18.55 N ATOM 2442 CA VAL A 334 −16.450 −5.462 −49.409 1.00 20.35 C ATOM 2443 CB VAL A 334 −17.782 −5.170 −50.154 1.00 20.48 C ATOM 2444 CG1 VAL A 334 −18.584 −4.118 −49.401 1.00 20.35 C ATOM 2445 CG2 VAL A 334 −17.528 −4.729 −51.592 1.00 19.95 C ATOM 2446 C VAL A 334 −15.924 −6.856 −49.763 1.00 21.24 C ATOM 2447 O VAL A 334 −15.245 −7.050 −50.776 1.00 20.82 O ATOM 2448 N LYS A 335 −16.230 −7.819 −48.908 1.00 23.36 N ATOM 2449 CA LYS A 335 −15.883 −9.207 −49.167 1.00 25.74 C ATOM 2450 CB LYS A 335 −15.491 −9.900 −47.859 1.00 27.08 C ATOM 2451 CG LYS A 335 −15.107 −11.360 −48.009 1.00 28.42 C ATOM 2452 CD LYS A 335 −13.606 −11.568 −47.901 1.00 30.46 C ATOM 2453 CE LYS A 335 −13.187 −12.932 −48.441 1.00 32.01 C ATOM 2454 NZ LYS A 335 −14.169 −14.018 −48.125 1.00 33.25 N ATOM 2455 C LYS A 335 −17.096 −9.896 −49.764 1.00 26.04 C ATOM 2456 O LYS A 335 −18.167 −9.889 −49.151 1.00 25.19 O ATOM 2457 N LEU A 336 −16.940 −10.485 −50.949 1.00 26.91 N ATOM 2458 CA LEU A 336 −18.023 −11.298 −51.509 1.00 30.03 C ATOM 2459 CB LEU A 336 −18.274 −11.013 −52.997 1.00 29.79 C ATOM 2460 CG LEU A 336 −17.146 −10.998 −54.015 1.00 29.27 C ATOM 2461 CD1 LEU A 336 −17.555 −11.778 −55.251 1.00 29.42 C ATOM 2462 CD2 LEU A 336 −16.847 −9.561 −54.375 1.00 29.02 C ATOM 2463 C LEU A 336 −17.886 −12.803 −51.244 1.00 31.63 C ATOM 2464 O LEU A 336 −17.096 −13.488 −51.898 1.00 31.84 O ATOM 2465 N ASN A 337 −18.685 −13.295 −50.290 1.00 35.08 N ATOM 2466 CA ASN A 337 −18.662 −14.704 −49.843 1.00 39.02 C ATOM 2467 CB ASN A 337 −19.124 −14.813 −48.378 1.00 40.63 C ATOM 2468 CG ASN A 337 −18.176 −14.114 −47.398 1.00 42.42 C ATOM 2469 OD1 ASN A 337 −16.978 −13.950 −47.668 1.00 43.75 O ATOM 2470 ND2 ASN A 337 −18.711 −13.707 −46.245 1.00 41.47 N ATOM 2471 C ASN A 337 −19.484 −15.663 −50.720 1.00 39.92 C ATOM 2472 O ASN A 337 −19.923 −15.306 −51.825 1.00 40.64 O ATOM 2473 N GLU A 342 −24.711 −24.931 −51.491 1.00 42.39 N ATOM 2474 CA GLU A 342 −24.202 −23.572 −51.386 1.00 43.46 C ATOM 2475 CB GLU A 342 −23.991 −22.965 −52.790 1.00 42.66 C ATOM 2476 CG GLU A 342 −22.573 −22.444 −53.072 1.00 42.81 C ATOM 2477 CD GLU A 342 −22.381 −20.946 −52.807 1.00 43.94 C ATOM 2478 OE1 GLU A 342 −21.732 −20.269 −53.640 1.00 44.61 O ATOM 2479 OE2 GLU A 342 −22.858 −20.436 −51.767 1.00 43.62 O ATOM 2480 C GLU A 342 −25.149 −22.712 −50.524 1.00 44.50 C ATOM 2481 O GLU A 342 −25.794 −23.221 −49.607 1.00 44.04 O ATOM 2482 N GLN A 343 −25.202 −21.411 −50.812 1.00 47.08 N ATOM 2483 CA GLN A 343 −26.059 −20.457 −50.093 1.00 45.88 C ATOM 2484 CB GLN A 343 −25.466 −20.105 −48.719 1.00 48.52 C ATOM 2485 CG GLN A 343 −24.169 −19.290 −48.776 1.00 53.25 C ATOM 2486 CD GLN A 343 −23.259 −19.513 −47.570 1.00 53.83 C ATOM 2487 OE1 GLN A 343 −23.630 −19.247 −46.431 1.00 52.35 O ATOM 2488 NE2 GLN A 343 −22.053 −20.029 −47.823 1.00 52.28 N ATOM 2489 C GLN A 343 −26.307 −19.178 −50.915 1.00 43.55 C ATOM 2490 O GLN A 343 −26.913 −18.234 −50.415 1.00 45.41 O ATOM 2491 N GLY A 344 −25.837 −19.146 −52.159 1.00 39.86 N ATOM 2492 CA GLY A 344 −26.105 −18.015 −53.055 1.00 38.17 C ATOM 2493 C GLY A 344 −25.234 −16.797 −52.795 1.00 37.15 C ATOM 2494 O GLY A 344 −24.949 −16.466 −51.652 1.00 37.97 O ATOM 2495 N SER A 345 −24.827 −16.125 −53.866 1.00 36.49 N ATOM 2496 CA SER A 345 −23.875 −15.012 −53.797 1.00 35.91 C ATOM 2497 CB SER A 345 −23.645 −14.450 −55.187 1.00 33.26 C ATOM 2498 OG SER A 345 −22.904 −15.353 −55.965 1.00 32.43 O ATOM 2499 C SER A 345 −24.299 −13.880 −52.876 1.00 37.81 C ATOM 2500 O SER A 345 −25.406 −13.356 −53.005 1.00 39.29 O ATOM 2501 N TYR A 346 −23.408 −13.512 −51.953 1.00 39.44 N ATOM 2502 CA TYR A 346 −23.601 −12.346 −51.087 1.00 39.92 C ATOM 2503 CB TYR A 346 −24.109 −12.748 −49.691 1.00 45.98 C ATOM 2504 CG TYR A 346 −25.377 −12.009 −49.288 1.00 53.94 C ATOM 2505 CD1 TYR A 346 −25.351 −10.641 −48.941 1.00 53.48 C ATOM 2506 CE1 TYR A 346 −26.517 −9.966 −48.595 1.00 54.68 C ATOM 2507 CZ TYR A 346 −27.734 −10.660 −48.591 1.00 59.40 C ATOM 2508 OH TYR A 346 −28.904 −10.023 −48.247 1.00 62.09 O ATOM 2509 CE2 TYR A 346 −27.787 −12.008 −48.928 1.00 59.83 C ATOM 2510 CD2 TYR A 346 −26.618 −12.673 −49.278 1.00 59.01 C ATOM 2511 C TYR A 346 −22.317 −11.526 −50.951 1.00 37.68 C ATOM 2512 O TYR A 346 −21.209 −12.041 −51.118 1.00 37.25 O ATOM 2513 N VAL A 347 −22.485 −10.247 −50.639 1.00 33.85 N ATOM 2514 CA VAL A 347 −21.378 −9.353 −50.376 1.00 31.17 C ATOM 2515 CB VAL A 347 −21.328 −8.222 −51.441 1.00 31.07 C ATOM 2516 CG1 VAL A 347 −22.257 −7.068 −51.082 1.00 30.07 C ATOM 2517 CG2 VAL A 347 −19.898 −7.741 −51.665 1.00 31.04 C ATOM 2518 C VAL A 347 −21.529 −8.816 −48.942 1.00 30.11 C ATOM 2519 O VAL A 347 −22.642 −8.687 −48.446 1.00 30.96 O ATOM 2520 N VAL A 348 −20.414 −8.549 −48.269 1.00 28.64 N ATOM 2521 CA VAL A 348 −20.433 −8.050 −46.892 1.00 27.21 C ATOM 2522 CB VAL A 348 −20.251 −9.197 −45.860 1.00 26.79 C ATOM 2523 CG1 VAL A 348 −19.221 −8.840 −44.793 1.00 25.64 C ATOM 2524 CG2 VAL A 348 −21.591 −9.559 −45.228 1.00 26.24 C ATOM 2525 C VAL A 348 −19.360 −6.993 −46.719 1.00 27.03 C ATOM 2526 O VAL A 348 −18.333 −7.032 −47.394 1.00 27.17 O ATOM 2527 N ALA A 349 −19.599 −6.047 −45.816 1.00 27.36 N ATOM 2528 CA ALA A 349 −18.672 −4.932 −45.620 1.00 27.26 C ATOM 2529 CB ALA A 349 −19.408 −3.721 −45.057 1.00 27.85 C ATOM 2530 C ALA A 349 −17.525 −5.334 −44.714 1.00 26.24 C ATOM 2531 O ALA A 349 −17.749 −5.927 −43.671 1.00 26.49 O ATOM 2532 N MET A 350 −16.303 −5.023 −45.134 1.00 26.47 N ATOM 2533 CA MET A 350 −15.088 −5.310 −44.360 1.00 27.68 C ATOM 2534 CB MET A 350 −13.967 −5.782 −45.287 1.00 29.17 C ATOM 2535 CG MET A 350 −14.050 −7.224 −45.758 1.00 31.52 C ATOM 2536 SD MET A 350 −12.647 −7.697 −46.811 1.00 34.81 S ATOM 2537 CE MET A 350 −11.228 −7.210 −45.812 1.00 33.90 C ATOM 2538 C MET A 350 −14.605 −4.046 −43.662 1.00 27.94 C ATOM 2539 O MET A 350 −14.371 −4.027 −42.446 1.00 27.69 O ATOM 2540 N GLU A 351 −14.447 −2.997 −44.466 1.00 27.64 N ATOM 2541 CA GLU A 351 −13.916 −1.728 −44.030 1.00 26.74 C ATOM 2542 CB GLU A 351 −12.499 −1.557 −44.570 1.00 28.94 C ATOM 2543 CG GLU A 351 −11.397 −1.989 −43.625 1.00 32.92 C ATOM 2544 CD GLU A 351 −10.223 −1.010 −43.622 1.00 36.58 C ATOM 2545 OE1 GLU A 351 −9.176 −1.328 −44.241 1.00 38.37 O ATOM 2546 OE2 GLU A 351 −10.349 0.086 −43.008 1.00 37.46 O ATOM 2547 C GLU A 351 −14.764 −0.574 −44.540 1.00 25.08 C ATOM 2548 O GLU A 351 −15.487 −0.703 −45.552 1.00 25.60 O ATOM 2549 N THR A 352 −14.700 0.558 −43.844 1.00 21.59 N ATOM 2550 CA THR A 352 −15.315 1.810 −44.266 1.00 18.39 C ATOM 2551 CB THR A 352 −16.417 2.206 −43.268 1.00 17.52 C ATOM 2552 OG1 THR A 352 −17.603 1.493 −43.581 1.00 16.85 O ATOM 2553 CG2 THR A 352 −16.741 3.640 −43.364 1.00 18.20 C ATOM 2554 C THR A 352 −14.234 2.901 −44.373 1.00 17.10 C ATOM 2555 O THR A 352 −13.285 2.908 −43.603 1.00 17.17 O ATOM 2556 N PHE A 353 −14.360 3.800 −45.343 1.00 16.02 N ATOM 2557 CA PHE A 353 −13.434 4.931 −45.472 1.00 14.91 C ATOM 2558 CB PHE A 353 −12.577 4.838 −46.746 1.00 15.41 C ATOM 2559 CG PHE A 353 −11.810 3.553 −46.873 1.00 16.17 C ATOM 2560 CD1 PHE A 353 −10.584 3.387 −46.223 1.00 16.20 C ATOM 2561 CE1 PHE A 353 −9.876 2.192 −46.336 1.00 16.37 C ATOM 2562 CZ PHE A 353 −10.392 1.144 −47.091 1.00 16.26 C ATOM 2563 CE2 PHE A 353 −11.613 1.296 −47.751 1.00 16.43 C ATOM 2564 CD2 PHE A 353 −12.314 2.492 −47.647 1.00 16.33 C ATOM 2565 C PHE A 353 −14.228 6.214 −45.492 1.00 13.90 C ATOM 2566 O PHE A 353 −15.120 6.381 −46.321 1.00 13.55 O ATOM 2567 THR A 354 −13.873 7.129 −44.595 1.00 13.01 N ATOM 2568 CA THR A 354 −14.614 8.373 −44.403 1.00 12.36 C ATOM 2569 CB THR A 354 −13.956 9.250 −43.325 1.00 12.24 C ATOM 2570 OG1 THR A 354 −13.791 8.471 −42.140 1.00 12.49 O ATOM 2571 CG2 THR A 354 −14.824 10.426 −42.974 1.00 12.27 C ATOM 2572 C THR A 354 −14.790 9.173 −45.675 1.00 11.86 C ATOM 2573 O THR A 354 −13.822 9.458 −46.370 1.00 11.56 O ATOM 2574 N ASN A 355 −16.045 9.500 −45.988 1.00 11.56 N ATOM 2575 CA ASN A 355 −16.343 10.560 −46.955 1.00 11.36 C ATOM 2576 CB ASN A 355 −16.965 10.024 −48.250 1.00 10.78 C ATOM 2577 CG ASN A 355 −16.932 11.050 −49.380 1.00 10.61 C ATOM 2578 OD1 ASN A 355 −16.297 12.103 −49.274 1.00 10.29 O ATOM 2579 ND2 ASN A 355 −17.602 10.738 −50.472 1.00 10.57 N ATOM 2580 C ASN A 355 −17.209 11.674 −46.373 1.00 11.54 C ATOM 2581 O ASN A 355 −18.356 11.445 −45.985 1.00 11.86 O ATOM 2582 N LEU A 356 −16.659 12.883 −46.327 1.00 11.63 N ATOM 2583 CA LEU A 356 −17.458 14.059 −45.988 1.00 11.73 C ATOM 2584 CB LEU A 356 −16.576 15.193 −45.444 1.00 11.61 C ATOM 2585 CG LEU A 356 −15.512 14.842 −44.402 1.00 11.49 C ATOM 2586 CD1 LEU A 356 −14.839 16.107 −43.924 1.00 11.62 C ATOM 2587 CD2 LEU A 356 −16.093 14.089 −43.222 1.00 11.50 C ATOM 2588 C LEU A 356 −18.249 14.521 −47.209 1.00 11.75 C ATOM 2589 O LEU A 356 −19.248 15.199 −47.067 1.00 11.78 O ATOM 2590 N GLY A 357 −17.791 14.114 −48.394 1.00 11.89 N ATOM 2591 CA GLY A 357 −18.373 14.474 −49.703 1.00 12.26 C ATOM 2592 C GLY A 357 −19.878 14.465 −49.875 1.00 12.60 C ATOM 2593 O GLY A 357 −20.548 13.602 −49.304 1.00 13.04 O ATOM 2594 N PRO A 358 −20.363 15.201 −50.895 1.00 12.77 N ATOM 2595 CA PRO A 358 −21.027 16.492 −50.849 1.00 12.46 C ATOM 2596 CB PRO A 358 −22.404 16.228 −51.491 1.00 12.58 C ATOM 2597 CG PRO A 358 −22.556 14.752 −51.522 1.00 12.56 C ATOM 2598 CD PRO A 358 −21.135 14.307 −51.775 1.00 13.01 C ATOM 2599 C PRO A 358 −21.132 17.029 −49.444 1.00 12.35 C ATOM 2600 O PRO A 358 −21.839 16.460 −48.617 1.00 12.33 O ATOM 2601 N ILE A 359 −20.367 18.081 −49.163 1.00 12.46 N ATOM 2602 CA ILE A 359 −20.664 18.943 −48.034 1.00 12.20 C ATOM 2603 CB ILE A 359 −19.435 19.640 −47.461 1.00 11.94 C ATOM 2604 CG1 ILE A 359 −18.414 18.605 −47.033 1.00 11.88 C ATOM 2605 CD1 ILE A 359 −17.375 19.126 −46.071 1.00 12.02 C ATOM 2606 CG2 ILE A 359 −19.841 20.477 −46.260 1.00 12.09 C ATOM 2607 C ILE A 359 −21.661 19.946 −48.575 1.00 12.31 C ATOM 2608 O ILE A 359 −21.326 20.843 −49.353 1.00 12.20 O ATOM 2609 N VAL A 360 −22.902 19.743 −48.176 1.00 12.23 N ATOM 2610 CA VAL A 360 −24.019 20.381 −48.798 1.00 12.32 C ATOM 2611 CB VAL A 360 −25.139 19.333 −49.006 1.00 11.97 C ATOM 2612 CG1 VAL A 360 −26.180 19.358 −47.896 1.00 12.03 C ATOM 2613 CG2 VAL A 360 −25.785 19.527 −50.339 1.00 11.91 C ATOM 2614 C VAL A 360 −24.428 21.589 −47.950 1.00 12.82 C ATOM 2615 O VAL A 360 −25.115 21.485 −48.422 1.00 13.16 O ATOM 2616 N ASP A 361 −23.985 21.590 −46.692 1.00 13.58 N ATOM 2617 CA ASP A 361 −24.116 22.711 −45.759 1.00 14.20 C ATOM 2618 CB ASP A 361 −25.573 23.023 −45.462 1.00 15.47 C ATOM 2619 CG ASP A 361 −25.737 24.174 −44.461 1.00 17.20 C ATOM 2620 OD1 ASP A 361 −24.907 24.141 −44.467 1.00 17.38 O ATOM 2621 OD2 ASP A 361 −26.711 24.108 −43.664 1.00 18.39 O ATOM 2622 C ASP A 361 −23.409 22.347 −44.465 1.00 14.03 C ATOM 2623 O ASP A 361 −23.262 21.167 −44.163 1.00 14.11 O ATOM 2624 N MET A 362 −22.967 23.353 −43.709 1.00 13.88 N ATOM 2625 CA MET A 362 −22.294 23.124 −42.422 1.00 14.00 C ATOM 2626 CB MET A 362 −20.795 22.868 −42.628 1.00 14.03 C ATOM 2627 CG MET A 362 −19.983 24.082 −43.072 1.00 13.91 C ATOM 2628 SD MET A 362 −18.347 23.594 −43.652 1.00 13.89 S ATOM 2629 CE MET A 362 −17.575 25.192 −43.929 1.00 13.90 C ATOM 2630 C MET A 362 −22.499 24.277 −41.448 1.00 14.16 C ATOM 2631 O MET A 362 −22.950 25.341 −41.838 1.00 14.67 O ATOM 2632 N CYS A 363 −22.175 24.066 −40.181 1.00 14.45 N ATOM 2633 CA CYS A 363 −22.151 25.153 −39.212 1.00 15.06 C ATOM 2634 CB CYS A 363 −23.507 25.317 −38.546 1.00 15.06 C ATOM 2635 SG CYS A 363 −23.849 24.023 −37.338 1.00 15.23 S ATOM 2636 C CYS A 363 −21.110 24.877 −38.150 1.00 15.95 C ATOM 2637 O CYS A 363 −20.691 23.730 −37.960 1.00 15.73 O ATOM 2638 N VAL A 364 −20.712 25.934 −37.444 1.00 17.74 N ATOM 2639 CA VAL A 364 −19.688 25.841 −36.403 1.00 19.45 C ATOM 2640 CB VAL A 364 −18.593 26.913 −36.574 1.00 19.10 C ATOM 2641 CG1 VAL A 364 −17.461 26.669 −35.594 1.00 19.26 C ATOM 2642 CG2 VAL A 364 −18.053 26.898 −38.000 1.00 19.07 C ATOM 2643 C VAL A 364 −20.278 25.913 −34.999 1.00 21.05 C ATOM 2644 O VAL A 364 −21.057 26.809 −34.686 1.00 20.92 O ATOM 2645 N VAL A 365 −19.902 24.936 −34.181 1.00 23.78 N ATOM 2646 CA VAL A 365 −20.223 24.891 −32.765 1.00 26.65 C ATOM 2647 CB VAL A 365 −20.724 23.491 −32.372 1.00 27.02 C ATOM 2648 CG1 VAL A 365 −20.709 23.306 −30.859 1.00 27.17 C ATOM 2649 CG2 VAL A 365 −22.110 23.244 −32.948 1.00 26.67 C ATOM 2650 C VAL A 365 −18.959 25.206 −31.976 1.00 29.41 C ATOM 2651 O VAL A 365 −17.920 24.585 −32.202 1.00 29.13 O ATOM 2652 N ASP A 366 −19.072 26.161 −31.047 1.00 35.42 N ATOM 2653 CA ASP A 366 −17.952 26.703 −30.241 1.00 40.74 C ATOM 2654 CB ASP A 366 −17.101 25.595 −29.603 1.00 41.72 C ATOM 2655 CG ASP A 366 −17.560 25.236 −28.215 1.00 42.44 C ATOM 2656 OD1 ASP A 366 −17.140 25.927 −27.265 1.00 45.49 O ATOM 2657 OD2 ASP A 366 −18.326 24.258 −28.068 1.00 42.14 O ATOM 2658 C ASP A 366 −17.071 27.658 −31.032 1.00 45.09 C ATOM 2659 O ASP A 366 −16.312 27.250 −31.914 1.00 47.68 O ATOM 2660 N LEU A 367 −17.175 28.937 −30.713 1.00 50.28 N ATOM 2661 CA LEU A 367 −16.324 29.932 −31.342 1.00 55.43 C ATOM 2662 CB LEU A 367 −17.149 30.842 −32.269 1.00 56.79 C ATOM 2663 CG LEU A 367 −17.680 30.195 −33.564 1.00 56.43 C ATOM 2664 CD1 LEU A 367 −18.979 30.830 −34.057 1.00 54.94 C ATOM 2665 CD2 LEU A 367 −16.619 30.215 −34.660 1.00 55.26 C ATOM 2666 C LEU A 367 −15.545 30.715 −30.273 1.00 58.87 C ATOM 2667 O LEU A 367 −15.642 31.945 −30.183 1.00 59.40 O ATOM 2668 N GLU A 368 −14.799 29.971 −29.451 1.00 60.73 N ATOM 2669 CA GLU A 368 −13.858 30.536 −28.472 1.00 61.33 C ATOM 2670 CB GLU A 368 −14.580 30.947 −27.179 1.00 59.87 C ATOM 2671 C GLU A 368 −12.725 29.545 −28.157 1.00 63.08 C ATOM 2672 O GLU A 368 −12.174 28.884 −29.051 1.00 60.50 O ATOM 2673 N GLN A 372 −12.776 25.451 −27.814 1.00 51.93 N ATOM 2674 CA GLN A 372 −12.486 24.211 −28.538 1.00 50.78 C ATOM 2675 C GLN A 372 −12.603 24.415 −30.047 1.00 49.19 C ATOM 2676 O GLN A 372 −11.594 24.638 −30.730 1.00 49.67 O ATOM 2677 N GLY A 373 −13.838 24.340 −30.550 1.00 46.04 N ATOM 2678 CA GLY A 373 −14.144 24.566 −31.972 1.00 40.70 C ATOM 2679 C GLY A 373 −14.478 23.276 −32.697 1.00 36.55 C ATOM 2680 O GLY A 373 −13.614 22.418 −32.875 1.00 37.21 O ATOM 2681 N GLN A 374 −15.735 23.113 −33.093 1.00 32.53 N ATOM 2682 CA GLN A 374 −16.113 21.924 −33.856 1.00 29.15 C ATOM 2683 CB GLN A 374 −16.612 20.793 −32.954 1.00 29.42 C ATOM 2684 CG GLN A 374 −18.067 20.897 −32.559 1.00 31.55 C ATOM 2685 CD GLN A 374 −18.494 19.816 −31.582 1.00 33.38 C ATOM 2686 OE1 GLN A 374 −19.673 19.725 −31.211 1.00 34.04 O ATOM 2687 NE2 GLN A 374 −17.538 18.996 −31.145 1.00 33.82 N ATOM 2688 C GLN A 374 −17.096 22.231 −34.978 1.00 25.87 C ATOM 2689 O GLN A 374 −17.948 23.117 −34.866 1.00 27.88 O ATOM 2690 N LEU A 375 −16.950 21.484 −36.062 1.00 22.20 N ATOM 2691 CA LEU A 375 −17.629 21.778 −37.94 1.00 19.60 C ATOM 2692 CB LEU A 375 −16.601 21.839 −38.410 1.00 19.42 C ATOM 2693 CG LEU A 375 −17.054 22.172 −39.819 1.00 19.98 C ATOM 2694 CD1 LEU A 375 −17.587 23.589 −39.918 1.00 20.06 C ATOM 2695 CD2 LEU A 375 −15.870 22.008 −40.741 1.00 20.34 C ATOM 2696 C LEU A 375 −18.625 20.676 −37.541 1.00 18.01 C ATOM 2697 O LEU A 375 −18.317 19.514 −37.332 1.00 18.45 O ATOM 2698 N VAL A 376 −19.838 21.029 −37.940 1.00 16.28 N ATOM 2699 CA VAL A 376 −20.850 20.003 −38.205 1.00 15.45 C ATOM 2700 CB VAL A 376 −22.082 20.152 −37.278 1.00 14.93 C ATOM 2701 CG1 VAL A 376 −23.056 18.993 −37.486 1.00 14.41 C ATOM 2702 CG2 VAL A 376 −21.655 20.241 −35.825 1.00 14.44 C ATOM 2703 C VAL A 376 −21.273 20.066 −39.677 1.00 15.03 C ATOM 2704 O VAL A 376 −21.519 21.156 −40.200 1.00 15.54 O ATOM 2705 N THR A 377 −21.343 18.934 −40.367 1.00 13.94 N ATOM 2706 CA THR A 377 −21.742 19.020 −41.771 1.00 13.61 C ATOM 2707 CB THR A 377 −20.620 18.625 −42.747 1.00 13.28 C ATOM 2708 OG1 THR A 377 −20.491 17.207 −42.744 1.00 13.43 O ATOM 2709 CG2 THR A 377 −19.306 19.269 −42.387 1.00 13.05 C ATOM 2710 C THR A 377 −22.978 18.211 −42.145 1.00 13.36 C ATOM 2711 O THR A 377 −23.268 17.162 −41.545 1.00 13.22 O ATOM 2712 N CYS A 378 −23.685 18.706 −43.157 1.00 12.81 N ATOM 2713 CA CYS A 378 −24.672 17.919 −43.855 1.00 12.64 C ATOM 2714 CB CYS A 378 −25.828 18.795 −44.304 1.00 12.74 C ATOM 2715 SG CYS A 378 −26.703 19.527 −42.914 1.00 12.82 S ATOM 2716 C CYS A 378 −23.990 17.270 −45.042 1.00 12.44 C ATOM 2717 O CYS A 378 −23.731 17.930 −46.052 1.00 12.44 O ATOM 2718 N SER A 379 −23.691 15.975 −44.901 1.00 12.26 N ATOM 2719 CA SER A 379 −22.870 15.228 −45.863 1.00 11.86 C ATOM 2720 CB SER A 379 −21.644 14.648 −45.172 1.00 11.74 C ATOM 2721 OG SER A 379 −20.775 15.671 −44.734 1.00 11.56 O ATOM 2722 C SER A 379 −23.642 14.109 −46.524 1.00 11.78 C ATOM 2723 O SER A 379 −24.519 13.490 −45.912 1.00 11.93 O ATOM 2724 N GLY A 380 −23.330 13.866 −47.788 1.00 11.69 N ATOM 2725 CA GLY A 380 −23.923 12.759 −48.503 1.00 11.96 C ATOM 2726 C GLY A 380 −25.344 12.964 −48.984 1.00 12.33 C ATOM 2727 O GLY A 380 −25.888 14.075 −48.953 1.00 12.47 O ATOM 2728 N ALA A 381 −25.954 11.870 −49.426 1.00 12.52 N ATOM 2729 CA ALA A 381 −27.173 11.936 −50.220 1.00 12.63 C ATOM 2730 CB ALA A 381 −26.833 12.317 −51.659 1.00 12.47 C ATOM 2731 C ALA A 381 −27.925 10.609 −50.177 1.00 12.78 C ATOM 2732 O ALA A 381 −27.313 9.541 −50.055 1.00 12.78 O ATOM 2733 N PHE A 382 −29.251 10.684 −50.285 1.00 12.81 N ATOM 2734 CA PHE A 382 −30.110 9.512 −50.198 1.00 12.87 C ATOM 2735 CB PHE A 382 −30.138 8.795 −51.528 1.00 13.21 C ATOM 2736 CG PHE A 382 −30.129 9.733 −52.694 1.00 13.87 C ATOM 2737 CD1 PHE A 382 −31.261 10.476 −53.017 1.00 14.21 C ATOM 2738 CE1 PHE A 382 −31.257 11.357 −54.095 1.00 14.38 C ATOM 2739 CZ PHE A 382 −30.112 11.510 −54.856 1.00 14.32 C ATOM 2740 CE2 PHE A 382 −28.971 10.785 −54.539 1.00 14.43 C ATOM 2741 CD2 PHE A 382 −28.979 9.908 −53.460 1.00 14.19 C ATOM 2742 C PHE A 382 −29.695 8.619 −49.027 1.00 12.86 C ATOM 2743 O PHE A 382 −29.614 9.109 −47.907 1.00 12.94 O ATOM 2744 N LYS A 383 −29.414 7.339 −49.249 1.00 12.98 N ATOM 2745 CA LYS A 383 −29.166 6.458 −48.097 1.00 13.48 C ATOM 2746 CB LYS A 383 −29.280 4.970 −48.467 1.00 13.45 C ATOM 2747 CG LYS A 383 −28.300 4.444 −49.507 1.00 13.68 C ATOM 2748 CD LYS A 383 −28.423 2.923 −49.601 1.00 13.76 C ATOM 2749 CE LYS A 383 −27.251 2.273 −50.326 1.00 14.10 C ATOM 2750 NZ LYS A 383 −26.025 2.129 −49.492 1.00 13.74 N ATOM 2751 C LYS A 383 −27.855 6.794 −47.345 1.00 13.86 C ATOM 2752 O LYS A 383 −27.682 6.461 −46.153 1.00 14.01 O ATOM 2753 N GLU A 384 −26.975 7.519 −48.028 1.00 13.90 N ATOM 2754 CA GLU A 384 −25.685 7.884 −47.470 1.00 14.01 C ATOM 2755 CB GLU A 384 −24.660 8.046 −48.587 1.00 14.80 C ATOM 2756 CG GLU A 384 −24.640 6.903 −49.592 1.00 16.26 C ATOM 2757 CD GLU A 384 −24.344 5.565 −48.948 1.00 17.79 C ATOM 2758 OE1 GLU A 384 −23.604 5.566 −47.920 1.00 19.21 O ATOM 2759 OE2 GLU A 384 −24.846 4.523 −49.461 1.00 17.80 O ATOM 2760 C GLU A 384 −25.718 9.134 −46.597 1.00 13.39 C ATOM 2761 O GLU A 384 −24.725 9.452 −45.930 1.00 13.32 O ATOM 2762 N GLY A 385 −26.848 9.838 −46.594 1.00 12.81 N ATOM 2763 CA GLY A 385 −26.974 11.086 −45.840 1.00 12.23 C ATOM 2764 C GLY A 385 −26.512 10.945 −44.403 1.00 11.81 C ATOM 2765 O GLY A 385 −26.864 9.986 −43.722 1.00 12.01 O ATOM 2766 N SER A 386 −25.701 11.883 −43.940 1.00 11.43 N ATOM 2767 CA SER A 386 −25.188 11.806 −42.583 1.00 11.42 C ATOM 2768 CB SER A 386 −23.917 10.928 −42.499 1.00 11.40 C ATOM 2769 OG SER A 386 −22.783 11.560 −43.090 1.00 11.22 O ATOM 2770 C SER A 386 −24.878 13.169 −42.042 1.00 11.35 C ATOM 2771 O SER A 386 −24.697 14.121 −42.798 1.00 11.08 O ATOM 2772 N LEU A 387 −24.812 13.249 −40.720 1.00 11.52 N ATOM 2773 CA LEU A 387 −24.147 14.348 −40.074 1.00 11.92 C ATOM 2774 CB LEU A 387 −24.886 14.745 −38.800 1.00 11.64 C ATOM 2775 CG LEU A 387 −26.249 15.398 −39.073 1.00 11.59 C ATOM 2776 CD1 LEU A 387 −26.787 16.104 −37.836 1.00 11.52 C ATOM 2777 CD2 LEU A 387 −26.186 16.361 −40.257 1.00 11.39 C ATOM 2778 C LEU A 387 −22.708 13.918 −39.778 1.00 12.49 C ATOM 2779 O LEU A 387 −22.481 12.778 −39.329 1.00 12.62 O ATOM 2800 N ARG A 388 −21.744 14.799 −40.088 1.00 12.57 N ATOM 2781 CA ARG A 388 −20.358 14.620 −39.658 1.00 12.82 C ATOM 2782 CB ARG A 388 −19.390 14.680 −40.839 1.00 12.17 C ATOM 2783 CG ARG A 388 −19.657 13.658 −41.936 1.00 11.89 C ATOM 2784 CD ARG A 388 −19.388 12.221 −41.510 1.00 11.48 C ATOM 2785 NE ARG A 388 −20.055 11.271 −42.402 1.00 11.25 N ATOM 2786 CZ ARG A 388 −19.450 10.291 −43.069 1.00 11.20 C ATOM 2787 NH1 ARG A 388 −18.152 10.097 −42.953 1.00 11.41 N ATOM 2788 NH2 ARG A 388 −20.145 9.491 −43.851 1.00 11.06 N ATOM 2789 C ARG A 388 −19.987 15.679 −38.613 1.00 13.83 C ATOM 2790 O ARG A 388 −20.147 16.888 −38.858 1.00 14.32 O ATOM 2791 N ILE A 389 −19.505 15.214 −37.453 1.00 14.39 N ATOM 2792 CA ILE A 389 −18.971 16.084 −36.402 1.00 14.98 C ATOM 2793 CB ILE A 389 −19.503 15.706 −35.002 1.00 15.18 C ATOM 2794 CG1 ILE A 389 −21.025 15.574 −35.014 1.00 15.58 C ATOM 2795 CD1 ILE A 389 −21.543 14.261 −35.556 1.00 15.81 C ATOM 2796 CG2 ILE A 389 −19.146 16.785 −33.992 1.00 15.21 C ATOM 2797 C ILE A 389 −17.452 15.983 −36.402 1.00 15.10 C ATOM 2798 O ILE A 389 −16.920 14.897 −36.248 1.00 15.47 O ATOM 2799 N ILE A 390 −16.774 17.117 −36.577 1.00 15.22 N ATOM 2800 CA ILE A 390 −15.325 17.165 −36.778 1.00 15.65 C ATOM 2801 CB ILE A 390 −14.961 17.774 −38.141 1.00 15.37 C ATOM 2802 CG1 ILE A 390 −15.519 16.922 −39.262 1.00 15.72 C ATOM 2803 CD1 ILE A 390 −15.465 17.588 −40.613 1.00 16.03 C ATOM 2804 CG2 ILE A 390 −13.456 17.887 −38.291 1.00 15.48 C ATOM 2805 C ILE A 390 −14.665 18.031 −35.732 1.00 16.38 C ATOM 2806 O ILE A 390 −14.927 19.241 −35.669 1.00 16.56 O ATOM 2807 N ARG A 391 −13.804 17.409 −34.924 1.00 17.28 N ATOM 2808 CA ARG A 391 −13.002 18.112 −33.919 1.00 18.14 C ATOM 2809 CB ARG A 391 −13.467 17.782 −32.501 1.00 17.08 C ATOM 2810 C ARG A 391 −11.529 17.757 −34.090 1.00 19.50 C ATOM 2811 O ARG A 391 −11.179 16.611 −34.393 1.00 19.77 O ATOM 2812 N ASN A 392 −10.671 18.758 −33.929 1.00 20.91 N ATOM 2813 CA ASN A 392 −9.246 18.538 −33.840 1.00 21.32 C ATOM 2814 CB ASN A 392 −8.514 19.817 −34.198 1.00 21.85 C ATOM 2815 CG ASN A 392 −7.131 19.561 −34.750 1.00 23.02 C ATOM 2816 OD1 ASN A 392 −6.730 18.406 −34.968 1.00 23.84 O ATOM 2817 ND2 ASN A 392 −6.385 20.640 −34.989 1.00 23.27 N ATOM 2818 C ASN A 392 −8.946 18.179 −32.402 1.00 22.14 C ATOM 2819 O ASN A 392 −9.557 18.735 −31.493 1.00 23.15 O ATOM 2820 N GLY A 393 −8.027 17.254 −32.175 1.00 22.26 N ATOM 2821 CA GLY A 393 −7.653 16.950 −30.809 1.00 22.20 C ATOM 2822 C GLY A 393 −6.817 15.714 −30.637 1.00 22.90 C ATOM 2823 O GLY A 393 −6.591 14.957 −31.585 1.00 22.77 O ATOM 2824 N ILE A 394 −6.342 15.522 −29.413 1.00 24.16 N ATOM 2825 CA ILE A 394 −5.660 14.300 −29.041 1.00 25.52 C ATOM 2826 CB ILE A 394 −4.648 14.534 −27.908 1.00 26.49 C ATOM 2827 CG1 ILE A 394 −3.594 15.555 −28.354 1.00 27.17 C ATOM 2828 CD1 ILE A 394 −2.612 15.955 −27.273 1.00 27.75 C ATOM 2829 CG2 ILE A 394 −3.999 13.215 −27.503 1.00 26.66 C ATOM 2830 C ILE A 394 −6.693 13.272 −28.612 1.00 25.49 C ATOM 2831 O ILE A 394 −7.428 13.49 −27.654 1.00 25.29 O ATOM 2832 N GLY A 395 −6.743 12.160 −29.344 1.00 26.03 N ATOM 2833 CA GLY A 395 −7.663 11.068 −29.059 1.00 25.95 C ATOM 2834 C GLY A 395 −7.143 10.090 −28.019 1.00 26.92 C ATOM 2835 O GLY A 395 −5.942 10.041 −27.720 1.00 26.91 O ATOM 2836 N ILE A 396 −8.065 9.314 −27.463 1.00 27.46 N ATOM 2837 CA ILE A 396 −7.748 8.306 −26.474 1.00 27.74 C ATOM 2838 CB ILE A 396 −8.168 8.770 −25.063 1.00 27.72 C ATOM 2839 CG1 ILE A 396 −7.121 9.729 −24.511 1.00 27.93 C ATOM 2840 CD1 ILE A 396 −7.539 10.460 −23.243 1.00 28.64 C ATOM 2841 CG2 ILE A 396 −8.351 7.595 −24.111 1.00 27.95 C ATOM 2842 C ILE A 396 −8.431 7.002 −26.852 1.00 29.01 C ATOM 2843 O ILE A 396 −9.646 6.939 −26.982 1.00 28.88 O ATOM 2844 N HIS A 397 −7.624 5.976 −27.076 1.00 32.61 N ATOM 2845 CA HIS A 397 −8.101 4.611 −27.169 1.00 36.36 C ATOM 2846 CB HIS A 397 −6.995 3.728 −27.739 1.00 41.27 C ATOM 2847 CG HIS A 397 −7.483 2.679 −28.720 1.00 47.60 C ATOM 2848 ND1 HIS A 397 −7.174 1.367 −28.597 1.00 48.86 N ATOM 2849 CE1 HIS A 397 −7.738 0.677 −29.611 1.00 50.91 C ATOM 2850 NE2 HIS A 397 −8.411 1.549 −30.391 1.00 51.76 N ATOM 2851 CD2 HIS A 397 −8.274 2.791 −29.847 1.00 49.70 C ATOM 2852 C HIS A 397 −8.482 4.155 −25.780 1.00 36.75 C ATOM 2853 O HIS A 397 −7.735 4.360 −24.820 1.00 37.98 O ATOM 2854 N GLU A 398 −9.658 3.559 −25.641 1.00 36.38 N ATOM 2855 CA GLU A 398 −10.070 3.023 −24.349 1.00 35.42 C ATOM 2856 CB GLU A 398 −11.512 3.385 −24.055 1.00 36.55 C ATOM 2857 CG GLU A 398 −11.767 4.878 −24.025 1.00 38.98 C ATOM 2858 CD GLU A 398 −13.234 5.197 −23.848 1.00 40.95 C ATOM 2859 OE1 GLU A 398 −13.686 6.236 −24.393 1.00 40.78 O ATOM 2860 OE2 GLU A 398 −13.930 4.395 −23.175 1.00 41.22 O ATOM 2861 C GLU A 398 −9.904 1.521 −24.313 1.00 34.46 C ATOM 2862 O GLU A 398 −10.301 0.828 −25.240 1.00 35.34 O ATOM 2863 N HIS A 399 −9.320 1.016 −23.238 1.00 33.53 N ATOM 2864 CA HIS A 399 −9.094 −0.410 −23.119 1.00 33.10 C ATOM 2865 CB HIS A 399 −7.624 −0.695 −22.846 1.00 35.00 C ATOM 2866 CG HIS A 399 −6.700 −0.215 −23.948 1.00 36.95 C ATOM 2867 ND1 HIS A 399 −5.626 0.570 −23.709 1.00 36.97 N ATOM 2868 CE1 HIS A 399 −5.007 0.846 −24.873 1.00 37.06 C ATOM 2869 NE2 HIS A 399 −5.686 0.238 −25.866 1.00 37.24 N ATOM 2870 CD2 HIS A 399 −6.736 −0.422 −25.333 1.00 36.54 C ATOM 2871 C HIS A 399 −9.974 −1.032 −22.083 1.00 32.19 C ATOM 2872 O HIS A 399 −10.410 −2.174 −22.239 1.00 33.51 O ATOM 2873 N ALA A 400 −10.260 −0.280 −21.022 1.00 30.92 N ATOM 2874 CA ALA A 400 −11.107 −0.762 −19.928 1.00 29.60 C ATOM 2875 CB ALA A 400 −10.252 −1.418 −18.848 1.00 29.40 C ATOM 2876 C ALA A 400 −11.985 0.341 −19.323 1.00 28.81 C ATOM 2877 O ALA A 400 −11.585 1.504 −19.249 1.00 29.05 O ATOM 2878 N SER A 401 −13.179 −0.041 −18.885 1.00 27.59 N ATOM 2879 CA SER A 401 −14.077 0.860 −18.175 1.00 27.15 C ATOM 2880 CB SER A 401 −15.325 1.111 −19.028 1.00 26.60 C ATOM 2881 OG SER A 401 −16.239 1.986 −18.404 1.00 25.91 O ATOM 2882 C SER A 401 −14.454 0.206 −16.842 1.00 27.65 C ATOM 2883 O SER A 401 −14.743 −1.000 −16.802 1.00 28.53 O ATOM 2884 N ILE A 402 −14.421 0.983 −15.752 1.00 27.24 N ATOM 2885 CA ILE A 402 −14.922 0.513 −14.445 1.00 27.38 C ATOM 2886 CB ILE A 402 −13.795 0.294 −13.397 1.00 26.88 C ATOM 2887 CG1 ILE A 402 −12.883 −0.865 −13.812 1.00 26.42 C ATOM 2888 CD1 ILE A 402 −11.638 −1.007 −12.964 1.00 26.59 C ATOM 2889 CG2 ILE A 402 −14.385 0.030 −12.011 1.00 25.86 C ATOM 2890 C ILE A 402 −15.975 1.459 −13.878 1.00 28.23 C ATOM 2891 O ILE A 402 −15.735 2.663 −13.734 1.00 28.77 O ATOM 2892 N ASP A 403 −17.137 0.892 −13.557 1.00 29.02 N ATOM 2893 CA ASP A 403 −18.233 1.608 −12.914 1.00 29.31 C ATOM 2894 CB ASP A 403 −19.543 0.827 −13.110 1.00 30.44 C ATOM 2895 CG ASP A 403 −20.779 1.576 −12.603 1.00 31.21 C ATOM 2896 OD1 ASP A 403 −20.741 2.824 −12.489 1.00 31.95 O ATOM 2897 OD2 ASP A 403 −21.806 0.901 −12.341 1.00 30.39 O ATOM 2898 C ASP A 403 −17.943 1.841 −11.420 1.00 29.62 C ATOM 2899 O ASP A 403 −18.218 0.985 −10.572 1.00 28.37 O ATOM 2900 N LEU A 404 −17.365 3.007 −11.127 1.00 30.69 N ATOM 2901 CA LEU A 404 −17.207 3.514 −9.765 1.00 30.58 C ATOM 2902 CB LEU A 404 −15.779 3.327 −9.278 1.00 30.29 C ATOM 2903 CG LEU A 404 −15.496 2.061 −8.493 1.00 30.93 C ATOM 2904 CD1 LEU A 404 −14.009 1.978 −8.196 1.00 31.97 C ATOM 2905 CD2 LEU A 404 −16.296 2.064 −7.204 1.00 31.00 C ATOM 2906 C LEU A 404 −17.563 4.993 −9.695 1.00 30.83 C ATOM 2907 O LEU A 404 −16.832 5.832 −10.219 1.00 30.72 O ATOM 2908 N PRO A 405 −18.678 5.323 −9.025 1.00 31.76 N ATOM 2909 CA PRO A 405 −19.067 6.729 −8.923 1.00 32.25 C ATOM 2910 CB PRO A 405 −20.560 6.648 −8.600 1.00 31.33 C ATOM 2911 CG PRO A 405 −20.750 5.305 −7.952 1.00 31.00 C ATOM 2912 CD PRO A 405 −19.555 4.444 −8.228 1.00 30.72 C ATOM 2913 C PRO A 405 −18.305 7.494 −7.819 1.00 33.22 C ATOM 2914 O PRO A 405 −18.006 6.932 −6.759 1.00 32.71 O ATOM 2915 N GLY A 406 −17.966 8.752 −8.093 1.00 34.02 N ATOM 2916 CA GLY A 406 −17.504 9.676 −7.053 1.00 35.28 C ATOM 2917 C GLY A 406 −16.004 9.817 −6.830 1.00 36.55 C ATOM 2918 O GLY A 406 −15.575 10.439 −5.855 1.00 36.75 O ATOM 2919 N ILE A 407 −15.201 9.260 −7.730 1.00 36.77 N ATOM 2920 CA ILE A 407 −13.745 9.305 −7.590 1.00 34.79 C ATOM 2921 CB ILE A 407 −13.061 8.666 −8.809 1.00 33.85 C ATOM 2922 CG1 ILE A 407 −13.474 7.198 −8.923 1.00 33.29 C ATOM 2923 CD1 ILE A 407 −12.978 6.507 −10.174 1.00 34.35 C ATOM 2924 CG2 ILE A 407 −11.552 8.809 −8.713 1.00 34.23 C ATOM 2925 C ILE A 407 −13.249 10.741 −7.387 1.00 34.87 C ATOM 2926 O ILE A 407 −13.648 11.648 −8.114 1.00 33.88 O ATOM 2927 N LYS A 408 −12.398 10.938 −6.379 1.00 35.25 N ATOM 2928 CA LYS A 408 −11.830 12.254 −6.091 1.00 34.53 C ATOM 2929 CB LYS A 408 −12.365 12.800 −4.760 1.00 35.10 C ATOM 2930 CG LYS A 408 −13.888 12.850 −4.682 1.00 36.15 C ATOM 2931 CD LYS A 408 −14.422 14.212 −4.265 1.00 36.47 C ATOM 2932 CE LYS A 408 −15.821 14.430 −4.832 1.00 37.03 C ATOM 2933 NZ LYS A 408 −16.021 15.817 −5.348 1.00 37.17 N ATOM 2934 C LYS A 408 −10.289 12.292 −6.148 1.00 35.15 C ATOM 2935 O LYS A 408 −9.664 13.296 −5.776 1.00 35.73 O ATOM 2936 N GLY A 409 −9.686 11.210 −6.641 1.00 35.09 N ATOM 2937 CA GLY A 409 −8.233 11.149 −6.841 1.00 35.28 C ATOM 2938 C GLY A 409 −7.744 9.821 −7.392 1.00 35.85 C ATOM 2939 O GLY A 409 −8.348 8.783 −7.134 1.00 38.14 O ATOM 2940 N LEU A 410 −6.634 9.858 −8.130 1.00 35.60 N ATOM 2941 CA LEU A 410 −6.063 8.673 −8.784 1.00 35.78 C ATOM 2942 CB LEU A 410 −6.357 8.725 −10.283 1.00 36.55 C ATOM 2943 CG LEU A 410 −7.312 7.706 −10.904 1.00 38.24 C ATOM 2944 CD1 LEU A 410 −8.590 7.562 −10.098 1.00 38.03 C ATOM 2945 CD2 LEU A 410 −7.625 8.088 −12.342 1.00 37.83 C ATOM 2946 C LEU A 410 −4.556 8.603 −8.599 1.00 36.28 C ATOM 2947 O LEU A 410 −3.857 9.583 −8.856 1.00 40.41 O ATOM 2948 N TRP A 411 −4.040 7.456 −8.168 1.00 34.69 N ATOM 2949 CA TRP A 411 −2.583 7.281 −8.083 1.00 34.83 C ATOM 2950 CB TRP A 411 −2.072 7.539 −6.683 1.00 33.13 C ATOM 2951 CG TRP A 411 −2.425 8.894 −6.163 1.00 31.82 C ATOM 2952 CD1 TRP A 411 −1.639 10.041 −6.180 1.00 31.36 C ATOM 2953 NE1 TRP A 411 −2.303 11.095 −5.610 1.00 30.95 N ATOM 2954 CE2 TRP A 411 −3.534 10.713 −5.201 1.00 31.90 C ATOM 2955 CD2 TRP A 411 −3.676 9.290 −5.534 1.00 31.35 C ATOM 2956 CE3 TRP A 411 −4.861 8.632 −5.214 1.00 31.15 C ATOM 2957 CZ3 TRP A 411 −5.881 9.361 −4.585 1.00 31.63 C ATOM 2958 CH2 TRP A 411 −5.730 10.728 −4.275 1.00 31.66 C ATOM 2959 CZ2 TRP A 411 −4.555 11.430 −4.579 1.00 32.06 C ATOM 2960 C TRP A 411 −2.110 5.932 −8.525 1.00 36.41 C ATOM 2961 O TRP A 411 −2.695 4.904 −8.142 1.00 38.05 O ATOM 2962 N PRO A 412 −1.037 5.910 −9.341 1.00 34.67 N ATOM 2963 CA PRO A 412 −0.395 4.673 −9.703 1.00 34.34 C ATOM 2964 CB PRO A 412 0.312 5.029 −10.995 1.00 33.91 C ATOM 2965 CG PRO A 412 0.716 6.438 −10.787 1.00 34.16 C ATOM 2966 CD PRO A 412 −0.397 7.061 −9.996 1.00 34.40 C ATOM 2967 C PRO A 412 0.616 4.309 −8.634 1.00 35.14 C ATOM 2968 O PRO A 412 1.103 5.171 −7.899 1.00 35.07 O ATOM 2969 N LEU A 413 0.946 3.035 −8.567 1.00 35.38 N ATOM 2970 CA LEU A 413 1.661 2.519 −7.433 1.00 35.34 C ATOM 2971 CB LEU A 413 0.676 2.386 −6.280 1.00 34.81 C ATOM 2972 CG LEU A 413 1.184 2.430 −4.863 1.00 33.65 C ATOM 2973 CD1 LEU A 413 0.408 3.484 −4.097 1.00 33.27 C ATOM 2974 CD2 LEU A 413 1.007 1.049 −4.266 1.00 33.58 C ATOM 2975 C LEU A 413 2.252 1.169 −7.816 1.00 36.22 C ATOM 2976 O LEU A 413 1.887 0.591 −8.853 1.00 35.05 O ATOM 2977 N ARG A 414 3.159 0.668 −6.981 1.00 37.14 N ATOM 2978 CA ARG A 414 3.967 −0.488 −7.345 1.00 38.28 C ATOM 2979 CB ARG A 414 5.327 −0.022 −7.850 1.00 37.85 C ATOM 2980 CG ARG A 414 5.919 −0.914 −8.915 1.00 38.86 C ATOM 2981 CD ARG A 414 6.918 −0.141 −9.756 1.00 40.63 C ATOM 2982 NE ARG A 414 7.916 0.546 −8.936 1.00 41.65 N ATOM 2983 CZ ARG A 414 8.069 1.866 −8.894 1.00 41.13 C ATOM 2984 NH1 ARG A 414 7.297 2.653 −9.638 1.00 39.81 N ATOM 2985 NH2 ARG A 414 9.003 2.397 −8.116 1.00 39.51 N ATOM 2986 C ARG A 414 4.124 −1.469 −6.194 1.00 38.44 C ATOM 2987 O ARG A 414 5.034 −1.344 −5.374 1.00 37.62 O ATOM 2988 N SER A 415 3.237 −2.460 −6.156 1.00 40.81 N ATOM 2989 CA SER A 415 3.172 −3.420 −5.047 1.00 42.55 C ATOM 2990 CB SER A 415 1.956 −4.340 −5.214 1.00 40.80 C ATOM 2991 C SER A 415 4.452 −4.256 −4.823 1.00 43.55 C ATOM 2992 O SER A 415 4.551 −4.968 −3.819 1.00 44.34 O ATOM 2993 N ASP A 416 5.424 −4.154 −5.738 1.00 43.67 N ATOM 2994 CA ASP A 416 6.619 −5.017 −5.714 1.00 43.70 C ATOM 2995 CB ASP A 416 6.254 −6.426 −6.209 1.00 44.69 C ATOM 2996 CG ASP A 416 7.378 −7.089 −6.977 1.00 46.96 C ATOM 2997 OD1 ASP A 416 8.378 −7.519 −6.351 1.00 48.27 O ATOM 2998 OD2 ASP A 416 7.253 −7.178 −8.216 1.00 48.64 O ATOM 2999 C ASP A 416 7.835 −4.465 −6.490 1.00 42.71 C ATOM 3000 O ASP A 416 7.696 −4.038 −7.637 1.00 44.00 O ATOM 3001 N PRO A 417 9.036 −4.490 −5.864 1.00 42.41 N ATOM 3002 CA PRO A 417 10.266 −4.099 −6.560 1.00 41.42 C ATOM 3003 CB PRO A 417 11.205 −3.661 −5.417 1.00 41.46 C ATOM 3004 CG PRO A 417 10.420 −3.807 −4.138 1.00 41.70 C ATOM 3005 CD PRO A 417 9.295 −4.752 −4.437 1.00 41.98 C ATOM 3006 C PRO A 417 10.882 −5.263 −7.334 1.00 39.94 C ATOM 3007 O PRO A 417 10.684 −5.367 −8.547 1.00 39.31 O ATOM 3008 N GLU A 420 9.067 −2.698 −10.395 1.00 40.34 N ATOM 3009 CA GLU A 420 9.334 −2.932 −11.810 1.00 43.29 C ATOM 3010 CB GLU A 420 9.187 −4.443 −12.117 1.00 46.24 C ATOM 3011 CG GLU A 420 8.583 −4.850 −13.471 1.00 49.31 C ATOM 3012 CD GLU A 420 9.282 −4.262 −14.701 1.00 50.98 C ATOM 3013 OE1 GLU A 420 10.482 −3.896 −14.618 1.00 51.24 O ATOM 3014 OE2 GLU A 420 8.614 −4.172 −15.762 1.00 50.52 O ATOM 3015 C GLU A 420 8.488 −2.034 −12.753 1.00 43.67 C ATOM 3016 O GLU A 420 9.034 −1.306 −13.586 1.00 42.76 O ATOM 3017 N THR A 421 7.164 −2.102 −12.582 1.00 44.02 N ATOM 3018 CA THR A 421 6.144 −1.444 −13.405 1.00 39.92 C ATOM 3019 CB THR A 421 5.824 −2.282 −14.659 1.00 39.53 C ATOM 3020 OG1 THR A 421 4.735 −1.688 −15.371 1.00 40.03 O ATOM 3021 CG2 THR A 421 5.429 −3.712 −14.284 1.00 38.88 C ATOM 3022 C THR A 421 4.894 −1.410 −12.531 1.00 39.49 C ATOM 3023 O THR A 421 4.707 −2.308 −11.710 1.00 41.18 O ATOM 3024 N ASP A 422 4.036 −0.404 −12.691 1.00 38.39 N ATOM 3025 CA ASP A 422 2.834 −0.304 −11.844 1.00 38.46 C ATOM 3026 CB ASP A 422 1.976 0.919 −12.201 1.00 42.97 C ATOM 3027 CG ASP A 422 2.795 2.182 −12.446 1.00 46.66 C ATOM 3028 OD1 ASP A 422 3.584 2.594 −11.562 1.00 49.51 O ATOM 3029 OD2 ASP A 422 2.615 2.784 −13.527 1.00 49.04 O ATOM 3030 C ASP A 422 1.966 −1.564 −11.926 1.00 36.45 C ATOM 3031 O ASP A 422 1.937 −2.250 −12.951 1.00 36.18 O ATOM 3032 N ASP A 423 1.265 −1.862 −10.839 1.00 35.16 N ATOM 3033 CA ASP A 423 0.350 −3.005 −10.791 1.00 35.99 C ATOM 3034 CB ASP A 423 1.071 −4.260 −10.280 1.00 37.22 C ATOM 3035 CG ASP A 423 1.612 −4.099 −8.853 1.00 39.67 C ATOM 3036 OD1 ASP A 423 1.628 −2.964 −8.321 1.00 40.84 O ATOM 3037 OD2 ASP A 423 2.026 −5.117 −8.258 1.00 42.05 O ATOM 3038 C ASP A 423 −0.826 −2.664 −9.886 1.00 35.02 C ATOM 3039 O ASP A 423 −1.732 −3.469 −9.669 1.00 34.40 O ATOM 3040 N THR A 424 −0.797 −1.449 −9.366 1.00 33.22 N ATOM 3041 CA THR A 424 −1.727 −1.036 −8.359 1.00 32.45 C ATOM 3042 CB THR A 424 −1.027 −0.938 −6.991 1.00 33.57 C ATOM 3043 OG1 THR A 424 −0.310 −2.154 −6.723 1.00 33.76 O ATOM 3044 CG2 THR A 424 −2.037 −0.665 −5.870 1.00 33.40 C ATOM 3045 C THR A 424 −2.254 0.325 −8.736 1.00 31.79 C ATOM 3046 O THR A 424 −1.489 1.241 −9.029 1.00 32.17 O ATOM 3047 N LEU A 425 −3.570 0.451 −8.743 1.00 32.09 N ATOM 3048 CA LEU A 425 −4.202 1.746 −8.876 1.00 32.56 C ATOM 3049 CB LEU A 425 −5.163 1.751 −10.067 1.00 34.11 C ATOM 3050 CG LEU A 425 −5.270 3.024 −10.918 1.00 35.45 C ATOM 3051 CD1 LEU A 425 −3.910 3.413 −11.484 1.00 35.66 C ATOM 3052 CD2 LEU A 425 −6.287 2.842 −12.043 1.00 34.77 C ATOM 3053 C LEU A 425 −4.936 2.033 −7.576 1.00 32.00 C ATOM 3054 O LEU A 425 −5.733 1.213 −7.107 1.00 30.88 O ATOM 3055 N VAL A 426 −4.634 3.179 −6.976 1.00 32.03 N ATOM 3056 CA VAL A 426 −5.287 3.591 −5.742 1.00 33.58 C ATOM 3057 CB VAL A 426 −4.267 4.021 −4.663 1.00 32.82 C ATOM 3058 CG1 VAL A 426 −4.976 4.506 −3.409 1.00 32.75 C ATOM 3059 CG2 VAL A 426 −3.339 2.870 −4.318 1.00 31.94 C ATOM 3060 C VAL A 426 −6.250 4.726 −6.061 1.00 35.83 C ATOM 3061 O VAL A 426 −5.873 5.716 −6.687 1.00 38.22 O ATOM 3062 N LEU A 427 −7.502 4.559 −5.655 1.00 38.10 N ATOM 3063 CA LEU A 427 −8.542 5.542 −5.922 1.00 40.65 C ATOM 3064 CB LEU A 427 −9.675 4.913 −6.740 1.00 40.37 C ATOM 3065 CG LEU A 427 −9.465 4.464 −8.191 1.00 39.32 C ATOM 3066 CD1 LEU A 427 −8.489 3.301 −8.313 1.00 38.60 C ATOM 3067 CD2 LEU A 427 −10.809 4.071 −8.781 1.00 38.86 C ATOM 3068 C LEU A 427 −9.090 6.037 −4.595 1.00 43.19 C ATOM 3069 O LEU A 427 −9.193 5.258 −3.639 1.00 44.47 O ATOM 3070 N SER A 428 −9.442 7.321 −4.528 1.00 43.82 N ATOM 3071 CA SER A 428 −10.066 7.867 −3.317 1.00 44.71 C ATOM 3072 CB SER A 428 −9.127 8.841 −2.596 1.00 45.06 C ATOM 3073 OG SER A 428 −8.911 10.010 −3.361 1.00 48.88 O ATOM 3074 C SER A 428 −11.439 8.501 −3.570 1.00 44.08 C ATOM 3075 O SER A 428 −11.698 9.064 −4.636 1.00 45.41 O ATOM 3076 N PHE A 429 −12.313 8.384 −2.579 1.00 41.84 N ATOM 3077 CA PHE A 429 −13.663 8.927 −2.650 1.00 41.84 C ATOM 3078 CB PHE A 429 −14.670 7.781 −2.679 1.00 41.35 C ATOM 3079 CG PHE A 429 −14.338 6.725 −3.697 1.00 40.90 C ATOM 3080 CD1 PHE A 429 −13.483 5.673 −3.377 1.00 41.12 C ATOM 3081 CE1 PHE A 429 −13.156 4.711 −4.318 1.00 40.03 C ATOM 3082 CZ PHE A 429 −13.676 4.792 −5.592 1.00 38.71 C ATOM 3083 CE2 PHE A 429 −14.523 5.837 −5.924 1.00 39.89 C ATOM 3084 CD2 PHE A 429 −14.846 6.800 −4.984 1.00 39.63 C ATOM 3085 C PHE A 429 −13.839 9.801 −1.424 1.00 42.24 C ATOM 3086 O PHE A 429 −12.900 9.915 −0.635 1.00 44.62 O ATOM 3087 N VAL A 430 −15.003 10.435 −1.257 1.00 41.49 N ATOM 3088 CA VAL A 430 −15.202 11.331 −0.102 1.00 41.03 C ATOM 3089 CB VAL A 430 −16.506 12.172 −0.186 1.00 40.96 C ATOM 3090 CG1 VAL A 430 −17.720 11.385 0.305 1.00 39.36 C ATOM 3091 CG2 VAL A 430 −16.347 13.474 0.594 1.00 39.87 C ATOM 3092 C VAL A 430 −15.092 10.560 1.214 1.00 40.81 C ATOM 3093 O VAL A 430 −15.847 9.624 1.456 1.00 38.75 O ATOM 3094 N GLY A 431 −14.106 10.942 2.028 1.00 43.03 N ATOM 3095 CA GLY A 431 −13.725 10.199 3.233 1.00 43.58 C ATOM 3096 C GLY A 431 −13.608 8.691 3.046 1.00 44.59 C ATOM 3097 O GLY A 431 −14.083 7.928 3.886 1.00 45.90 O ATOM 3098 N GLN A 432 −12.984 8.256 1.950 1.00 43.70 N ATOM 3099 CA GLN A 432 −12.837 6.823 1.652 1.00 43.89 C ATOM 3100 CB GLN A 432 −14.139 6.269 1.064 1.00 44.93 C ATOM 3101 CG GLN A 432 −14.264 4.753 1.104 1.00 46.17 C ATOM 3102 CD GLN A 432 −15.494 4.245 0.364 1.00 48.52 C ATOM 3103 OE1 GLN A 432 −16.407 5.014 0.041 1.00 49.50 O ATOM 3104 NE2 GLN A 432 −15.524 2.942 0.093 1.00 47.15 N ATOM 3105 C GLN A 432 −11.675 6.589 0.683 1.00 42.93 C ATOM 3106 O GLN A 432 −11.355 7.468 −0.119 1.00 44.12 O ATOM 3107 N THR A 433 −11.038 5.419 0.770 1.00 40.49 N ATOM 3108 CA THR A 433 −9.978 5.038 −0.178 1.00 38.78 C ATOM 3109 CB THR A 433 −8.575 5.348 0.365 1.00 37.51 C ATOM 3110 OG1 THR A 433 −8.507 6.723 0.750 1.00 38.64 O ATOM 3111 CG2 THR A 433 −7.509 5.064 −0.692 1.00 35.97 C ATOM 3112 C THR A 433 −10.043 3.562 −0.554 1.00 39.05 C ATOM 3113 O THR A 433 −10.181 2.699 0.314 1.00 39.30 O ATOM 3114 N ARG A 434 −9.946 3.286 −1.852 1.00 37.60 N ATOM 3115 CA ARG A 434 −9.956 1.921 −2.361 1.00 37.75 C ATOM 3116 CB ARG A 434 −11.213 1.651 −3.203 1.00 38.56 C ATOM 3117 CG ARG A 434 −12.553 1.740 −2.478 1.00 37.10 C ATOM 3118 CD ARG A 434 −13.591 0.901 −3.218 1.00 36.00 C ATOM 3119 NE ARG A 434 −14.928 1.488 −3.233 1.00 35.26 N ATOM 3120 CZ ARG A 434 −15.995 0.891 −3.759 1.00 35.28 C ATOM 3121 NH1 ARG A 434 −15.878 −0.311 −4.305 1.00 35.94 N ATOM 3122 NH2 ARG A 434 −17.181 1.492 −3.744 1.00 35.37 N ATOM 3123 C ARG A 434 −8.713 1.653 −3.208 1.00 37.45 C ATOM 3124 O ARG A 434 −8.176 2.561 −3.840 1.00 37.91 O ATOM 3125 N VAL A 435 −8.277 0.396 −3.224 1.00 37.25 N ATOM 3126 CA VAL A 435 −7.068 −0.017 −3.935 1.00 37.60 C ATOM 3127 CB VAL A 435 −5.986 −0.538 −2.952 1.00 37.32 C ATOM 3128 CG1 VAL A 435 −4.748 −1.020 −3.701 1.00 37.26 C ATOM 3129 CG2 VAL A 435 −5.608 0.51 −1.948 1.00 37.00 C ATOM 3130 C VAL A 435 −7.397 −1.104 −4.962 1.00 38.03 C ATOM 3131 O VAL A 435 −8.049 −2.100 −4.635 1.00 39.22 O ATOM 3132 N LEU A 436 −6.941 −0.911 −6.198 1.00 36.74 N ATOM 3133 CA LEU A 436 −7.201 −1.868 −7.267 1.00 36.55 C ATOM 3134 CB LEU A 436 −7.876 −1.175 −8.457 1.00 36.60 C ATOM 3135 CG LEU A 436 −9.246 −0.530 −8.239 1.00 35.55 C ATOM 3136 CD1 LEU A 436 −9.735 0.112 −9.525 1.00 34.84 C ATOM 3137 CD2 LEU A 436 −10.251 −1.551 −7.729 1.00 35.28 C ATOM 3138 C LEU A 436 −5.915 −2.521 −7.727 1.00 36.16 C ATOM 3139 O LEU A 436 −4.980 −1.830 −8.123 1.00 36.58 O ATOM 3140 N MET A 437 −5.862 −3.848 −7.682 1.00 35.58 N ATOM 3141 CA MET A 437 −4.694 −4.546 −8.206 1.00 36.20 C ATOM 3142 CB MET A 437 −4.337 −5.781 −7.356 1.00 37.96 C ATOM 3143 CG MET A 437 −4.865 −7.118 −7.850 1.00 40.73 C ATOM 3144 SD MET A 437 −4.283 −8.497 −6.838 1.00 43.43 S ATOM 3145 CE MET A 437 −2.599 −8.685 −7.433 1.00 41.94 C ATOM 3146 C MET A 437 −4.862 −4.875 −9.693 1.00 34.98 C ATOM 3147 O MET A 437 −5.966 −5.194 −10.151 1.00 36.42 O ATOM 3148 N LEU A 438 −3.768 −4.769 −10.443 1.00 32.03 N ATOM 3149 CA LEU A 438 −3.783 −5.058 −11.867 1.00 30.70 C ATOM 3150 CB LEU A 438 −3.297 −3.847 −12.659 1.00 31.02 C ATOM 3151 CG LEU A 438 −4.269 −2.670 −12.711 1.00 31.64 C ATOM 3152 CD1 LEU A 438 −4.247 −1.912 −11.397 1.00 33.39 C ATOM 3153 CD2 LEU A 438 −3.951 −1.733 −13.866 1.00 31.56 C ATOM 3154 C LEU A 438 −2.965 −6.292 −12.228 1.00 29.63 C ATOM 3155 O LEU A 438 −1.755 −6.329 −12.031 1.00 29.72 O ATOM 3156 N ASN A 439 −3.645 −7.310 −12.734 1.00 29.32 N ATOM 3157 CA ASN A 439 −2.989 −8.456 −13.344 1.00 30.36 C ATOM 3158 CB ASN A 439 −3.388 −9.765 −12.654 1.00 30.83 C ATOM 3159 CG ASN A 439 −2.353 −10.238 −11.647 1.00 31.42 C ATOM 3160 OD1 ASN A 439 −1.415 −10.962 −11.996 1.00 30.93 O ATOM 3161 ND2 ASN A 439 −2.524 −9.838 −10.385 1.00 31.31 N ATOM 3162 C ASN A 439 −3.395 −8.490 −14.797 1.00 30.86 C ATOM 3163 O ASN A 439 −4.564 −8.705 −15.109 1.00 31.43 O ATOM 3164 N GLY A 440 −2.439 −8.242 −15.687 1.00 31.02 N ATOM 3165 CA GLY A 440 −2.746 −8.092 −17.101 1.00 31.35 C ATOM 3166 C GLY A 440 −3.891 −7.117 −17.309 1.00 31.67 C ATOM 3167 O GLY A 440 −3.809 −5.949 −16.922 1.00 32.14 O ATOM 3168 N GLU A 441 −4.969 −7.608 −17.901 1.00 32.01 N ATOM 3169 CA GLU A 441 −6.120 −6.778 −18.203 1.00 33.36 C ATOM 3170 CB GLU A 441 −6.661 −7.101 −19.593 1.00 34.81 C ATOM 3171 CG GLU A 441 −6.035 −6.313 −20.726 1.00 36.48 C ATOM 3172 CD GLU A 441 −6.697 −6.606 −22.065 1.00 39.49 C ATOM 3173 OE1 GLU A 441 −5.960 −6.781 −23.054 1.00 40.89 O ATOM 3174 OE2 GLU A 441 −7.953 −6.670 −22.137 1.00 40.96 O ATOM 3175 C GLU A 441 −7.227 −6.957 −17.175 1.00 33.77 C ATOM 3176 O GLU A 441 −8.321 −6.397 −17.326 1.00 34.90 O ATOM 3177 N GLU A 442 −6.951 −7.732 −16.130 1.00 33.82 N ATOM 3178 CA GLU A 442 −7.954 −7.967 −15.086 1.00 34.39 C ATOM 3179 CB GLU A 442 −8.179 −9.464 −14.830 1.00 34.63 C ATOM 3180 CG GLU A 442 −6.931 −10.290 −14.567 1.00 34.42 C ATOM 3181 CD GLU A 442 −7.198 −11.782 −14.613 1.00 35.35 C ATOM 3182 OE1 GLU A 442 −8.304 −12.194 −15.036 1.00 36.06 O ATOM 3183 OE2 GLU A 442 −6.299 −12.551 −14.224 1.00 36.26 O ATOM 3184 C GLU A 442 −7.681 −7.206 −13.793 1.00 34.33 C ATOM 3185 O GLU A 442 −6.637 −7.385 −13.152 1.00 33.18 O ATOM 3186 N VAL A 443 −8.628 −6.331 −13.445 1.00 34.44 N ATOM 3187 CA VAL A 443 −8.535 −5.496 −12.254 1.00 34.09 C ATOM 3188 CB VAL A 443 −9.061 −4.067 −12.509 1.00 34.50 C ATOM 3189 CG1 VAL A 443 −8.958 −3.214 −11.248 1.00 34.03 C ATOM 3190 CG2 VAL A 443 −8.307 −3.411 −13.659 1.00 34.27 C ATOM 3191 C VAL A 443 −9.339 −6.149 −11.143 1.00 34.39 C ATOM 3192 O VAL A 443 −10.457 −6.628 −11.371 1.00 33.97 O ATOM 3193 N GLU A 444 −8.750 −6.181 −9.949 1.00 34.43 N ATOM 3194 CA GLU A 444 −9.366 −6.798 −8.780 1.00 33.68 C ATOM 3195 CB GLU A 444 −8.778 −8.190 −8.547 1.00 32.68 C ATOM 3196 CG GLU A 444 −9.718 −9.128 −7.818 1.00 33.73 C ATOM 3197 CD GLU A 444 −9.007 −10.261 −7.094 1.00 34.47 C ATOM 3198 OE1 GLU A 444 −9.193 −10.382 −5.864 1.00 33.93 O ATOM 3199 OE2 GLU A 444 −8.272 −11.039 −7.742 1.00 35.85 O ATOM 3200 C GLU A 444 −9.125 −5.904 −7.564 1.00 34.06 C ATOM 3201 O GLU A 444 −7.980 −5.533 −7.272 1.00 34.43 O ATOM 3202 N GLU A 445 −10.201 −5.538 −6.870 1.00 34.65 N ATOM 3203 CA GLU A 445 −10.090 −4.697 −5.675 1.00 35.46 C ATOM 3204 CB GLU A 445 −11.452 −4.149 −5.241 1.00 35.65 C ATOM 3205 CG GLU A 445 −11.523 −3.778 −3.766 1.00 36.50 C ATOM 3206 CD GLU A 445 −12.286 −2.493 −3.492 1.00 37.42 C ATOM 3207 OE1 GLU A 445 −11.874 −1.765 −2.550 1.00 37.33 O ATOM 3208 OE2 GLU A 445 −13.281 −2.210 −4.207 1.00 35.75 O ATOM 3209 C GLU A 445 −9.465 −5.487 −4.552 1.00 35.52 C ATOM 3210 O GLU A 445 −9.795 −6.651 −4.360 1.00 35.94 O ATOM 3211 N THR A 446 −8.564 −4.851 −3.811 1.00 36.34 N ATOM 3212 CA THR A 446 −7.866 −5.522 −2.718 1.00 38.20 C ATOM 3213 CB THR A 446 −6.520 −6.119 −3.205 1.00 37.81 C ATOM 3214 OG1 THR A 446 −5.972 −6.969 −2.193 1.00 37.76 O ATOM 3215 CG2 THR A 446 −5.511 −5.024 −3.571 1.00 37.79 C ATOM 3216 C THR A 446 −7.688 −4.611 −1.487 1.00 39.68 C ATOM 3217 O THR A 446 −8.249 −3.513 −1.434 1.00 40.02 O ATOM 3218 N GLU A 447 −6.948 −5.096 −0.491 1.00 42.51 N ATOM 3219 CA GLU A 447 −6.475 −4.276 0.631 1.00 45.02 C ATOM 3220 CB GLU A 447 −6.832 −4.938 1.970 1.00 43.40 C ATOM 3221 C GLU A 447 −4.952 −4.074 0.528 1.00 47.09 C ATOM 3222 O GLU A 447 −4.221 −4.987 0.113 1.00 48.13 O ATOM 3223 N LEU A 448 −4.476 −2.883 0.882 1.00 47.03 N ATOM 3224 CA LEU A 448 −3.037 −2.665 1.015 1.00 49.45 C ATOM 3225 CB LEU A 448 −2.583 −1.426 0.232 1.00 49.54 C ATOM 3226 CG LEU A 448 −1.073 −1.285 −0.031 1.00 49.09 C ATOM 3227 CD1 LEU A 448 −0.556 −2.430 −0.893 1.00 48.79 C ATOM 3228 CD2 LEU A 448 −0.749 0.052 −0.681 1.00 46.81 C ATOM 3229 C LEU A 448 −2.667 −2.532 2.489 1.00 52.10 C ATOM 3230 O LEU A 448 −3.091 −1.582 3.159 1.00 56.88 O ATOM 3231 N MET A 449 −1.891 −3.484 3.002 1.00 50.26 N ATOM 3232 CA MET A 449 −1.533 −3.465 4.420 1.00 49.85 C ATOM 3233 CB MET A 449 −0.796 −4.743 4.832 1.00 51.08 C ATOM 3234 CG MET A 449 −0.938 −5.102 6.305 1.00 49.54 C ATOM 3235 SD MET A 449 0.157 −6.464 6.765 1.00 53.97 S ATOM 3236 CE MET A 449 −0.720 −7.891 6.113 1.00 53.26 C ATOM 3237 C MET A 449 −0.705 −2.224 4.744 1.00 47.53 C ATOM 3238 O MET A 449 0.309 −1.945 4.104 1.00 45.58 O ATOM 3239 N GLY A 450 −1.171 −1.470 5.729 1.00 46.06 N ATOM 3240 CA GLY A 450 −0.505 −0.246 6.129 1.00 44.55 C ATOM 3241 C GLY A 450 −1.212 0.965 5.580 1.00 43.27 C ATOM 3242 O GLY A 450 −0.939 2.091 5.990 1.00 44.47 O ATOM 3243 N PHE A 451 −2.131 0.735 4.652 1.00 41.99 N ATOM 3244 CA PHE A 451 −2.870 1.824 4.044 1.00 41.83 C ATOM 3245 CB PHE A 451 −2.915 1.670 2.513 1.00 41.43 C ATOM 3246 CG PHE A 451 −1.887 2.507 1.784 1.00 41.39 C ATOM 3247 CD1 PHE A 451 −0.597 2.672 2.294 1.00 40.39 C ATOM 3248 CE1 PHE A 451 0.339 3.445 1.625 1.00 39.02 C ATOM 3249 CZ PHE A 451 0.002 4.060 0.430 1.00 38.89 C ATOM 3250 CE2 PHE A 451 −1.268 3.908 −0.094 1.00 40.12 C ATOM 3251 CD2 PHE A 451 −2.207 3.134 0.581 1.00 41.71 C ATOM 3252 C PHE A 451 −4.258 1.939 4.644 1.00 42.57 C ATOM 3253 O PHE A 451 −5.089 1.039 4.492 1.00 43.27 O ATOM 3254 N VAL A 452 −4.491 3.041 5.354 1.00 44.49 N ATOM 3255 CA VAL A 452 −5.812 3.341 5.924 1.00 46.79 C ATOM 3256 CB VAL A 452 −5.754 4.479 6.992 1.00 46.24 C ATOM 3257 CG1 VAL A 452 −5.867 5.867 6.363 1.00 45.37 C ATOM 3258 CG2 VAL A 452 −6.836 4.284 8.043 1.00 46.24 C ATOM 3259 C VAL A 452 −6.825 3.633 4.807 1.00 47.28 C ATOM 3260 O VAL A 452 −6.530 4.354 3.851 1.00 46.34 O ATOM 3261 N ASP A 453 −8.008 3.043 4.928 1.00 50.16 N ATOM 3262 CA ASP A 453 −9.002 3.083 3.860 1.00 52.96 C ATOM 3263 CB ASP A 453 −9.104 1.696 3.182 1.00 58.71 C ATOM 3264 CG ASP A 453 −7.833 1.332 2.350 1.00 63.02 C ATOM 3265 OD1 ASP A 453 −7.400 2.154 1.504 1.00 64.18 O ATOM 3266 OD2 ASP A 453 −7.282 0.214 2.528 1.00 61.14 O ATOM 3267 C ASP A 453 −10.364 3.584 4.368 1.00 50.20 C ATOM 3268 O ASP A 453 −11.413 3.135 3.913 1.00 48.99 O ATOM 3269 N ASP A 454 −10.321 4.525 5.314 1.00 49.02 N ATOM 3270 CA ASP A 454 −11.523 5.128 5.909 1.00 48.27 C ATOM 3271 CB ASP A 454 −11.730 4.651 7.364 1.00 48.66 C ATOM 3272 CG ASP A 454 −10.706 5.244 8.353 1.00 49.53 C ATOM 3273 OD1 ASP A 454 −9.730 5.896 7.917 1.00 50.63 O ATOM 3274 OD2 ASP A 454 −10.881 5.048 9.579 1.00 47.76 O ATOM 3275 C ASP A 454 −11.472 6.656 5.840 1.00 46.93 C ATOM 3276 O ASP A 454 −12.432 7.340 6.187 1.00 47.68 O ATOM 3277 N GLN A 455 −10.328 7.176 5.418 1.00 45.28 N ATOM 3278 CA GLN A 455 −10.178 8.589 5.134 1.00 44.72 C ATOM 3279 CB GLN A 455 −8.882 9.130 5.755 1.00 44.77 C ATOM 3280 CG GLN A 455 −8.786 9.027 7.270 1.00 44.22 C ATOM 3281 CD GLN A 455 −9.670 10.023 8.014 1.00 44.12 C ATOM 3282 OE1 GLN A 455 −10.523 10.693 7.430 1.00 43.57 O ATOM 3283 NE2 GLN A 455 −9.469 10.112 9.318 1.00 44.24 N ATOM 3284 C GLN A 455 −10.123 8.768 3.625 1.00 45.60 C ATOM 3285 O GLN A 455 −9.946 7.799 2.883 1.00 47.84 O ATOM 3286 N GLN A 456 −10.269 10.010 3.176 1.00 44.16 N ATOM 3287 CA GLN A 456 −9.982 10.382 1.793 1.00 41.98 C ATOM 3288 CB GLN A 456 −10.769 11.636 1.454 1.00 40.72 C ATOM 3289 CG GLN A 456 −10.383 12.324 0.167 1.00 39.48 C ATOM 3290 CD GLN A 456 −11.279 13.506 −0.104 1.00 40.28 C ATOM 3291 OE1 GLN A 456 −10.810 14.624 −0.271 1.00 42.05 O ATOM 3292 NE2 GLN A 456 −12.585 13.270 −0.120 1.00 40.55 N ATOM 3293 C GLN A 456 −8.478 10.632 1.620 1.00 41.23 C ATOM 3294 O GLN A 456 −7.871 11.338 2.425 1.00 41.71 O ATOM 3295 N THR A 457 −7.888 10.047 0.575 1.00 39.91 N ATOM 3296 CA THR A 457 −6.446 10.179 0.295 1.00 39.80 C ATOM 3297 CB THR A 457 −5.927 8.935 −0.453 1.00 38.87 C ATOM 3298 OG1 THR A 457 −5.998 7.798 0.414 1.00 37.70 O ATOM 3299 CG2 THR A 457 −4.485 9.127 −0.927 1.00 38.06 C ATOM 3300 C THR A 457 −6.104 11.438 −0.519 1.00 40.67 C ATOM 3301 O THR A 457 −6.765 11.731 −1.525 1.00 40.21 O ATOM 3302 N PHE A 458 −5.077 12.173 −0.085 1.00 41.65 N ATOM 3303 CA PHE A 458 −4.626 13.374 −0.814 1.00 44.31 C ATOM 3304 CB PHE A 458 −4.368 14.550 0.134 1.00 49.60 C ATOM 3305 CG PHE A 458 −5.619 15.282 0.533 1.00 55.86 C ATOM 3306 CD1 PHE A 458 −6.425 15.893 −0.435 1.00 57.18 C ATOM 3307 CE1 PHE A 458 −7.592 16.558 −0.073 1.00 59.11 C ATOM 3308 CZ PHE A 458 −7.964 16.619 1.265 1.00 61.35 C ATOM 3309 CE2 PHE A 458 −7.173 16.014 2.240 1.00 59.89 C ATOM 3310 CD2 PHE A 458 −6.009 15.348 1.873 1.00 57.81 C ATOM 3311 C PHE A 458 −3.420 13.128 −1.719 1.00 42.63 C ATOM 3312 O PHE A 458 −3.262 13.788 −2.751 1.00 43.72 O ATOM 3313 N PHE A 459 −2.566 12.191 −1.322 1.00 38.14 N ATOM 3314 CA PHE A 459 −1.523 11.688 −2.192 1.00 35.19 C ATOM 3315 CB PHE A 459 −0.287 12.593 −2.195 1.00 33.44 C ATOM 3316 CG PHE A 459 0.909 11.952 −2.842 1.00 32.80 C ATOM 3317 CD1 PHE A 459 1.080 12.003 −4.225 1.00 31.63 C ATOM 3318 CE1 PHE A 459 2.159 11.384 −4.832 1.00 30.73 C ATOM 3319 CZ PHE A 459 3.079 10.691 −4.062 1.00 31.21 C ATOM 3320 CE2 PHE A 459 2.916 10.618 −2.688 1.00 32.21 C ATOM 3321 CD2 PHE A 459 1.835 11.243 −2.082 1.00 32.33 C ATOM 3322 C PHE A 459 −1.106 10.322 −1.726 1.00 34.61 C ATOM 3323 O PHE A 459 −1.094 10.054 −0.538 1.00 36.92 O ATOM 3324 N CYS A 460 −0.750 9.459 −2.664 1.00 34.35 N ATOM 3325 CA CYS A 460 0.006 8.269 −2.332 1.00 35.21 C ATOM 3326 CB CYS A 460 −0.918 7.095 −2.011 1.00 37.29 C ATOM 3327 SG CYS A 460 −1.705 6.355 −3.448 1.00 42.12 S ATOM 3328 C CYS A 460 0.927 7.935 −3.483 1.00 35.30 C ATOM 3329 O CYS A 460 0.798 8.497 −4.570 1.00 36.13 O ATOM 3330 N GLY A 461 1.867 7.032 −3.241 1.00 34.39 N ATOM 3331 CA GLY A 461 2.760 6.585 −4.289 1.00 33.67 C ATOM 3332 C GLY A 461 4.036 6.018 −3.732 1.00 33.95 C ATOM 3333 O GLY A 461 4.174 5.866 −2.515 1.00 34.87 O ATOM 3334 N ASN A 462 4.968 5.702 −4.632 1.00 33.09 N ATOM 3335 CA ASN A 462 6.248 5.145 −4.256 1.00 33.16 C ATOM 3336 CB ASN A 462 6.888 4.418 −5.433 1.00 32.11 C ATOM 3337 CG ASN A 462 6.097 3.203 −5.870 1.00 32.20 C ATOM 3338 OD1 ASN A 462 6.475 2.067 −5.590 1.00 31.71 O ATOM 3339 ND2 ASN A 462 4.993 3.434 −6.567 1.00 32.99 N ATOM 3340 C ASN A 462 7.157 6.249 −3.769 1.00 35.61 C ATOM 3341 O ASN A 462 7.116 7.365 −4.295 1.00 34.91 O ATOM 3342 N VAL A 463 7.965 5.931 −2.753 1.00 39.77 N ATOM 3343 CA VAL A 463 8.932 6.875 −2.166 1.00 42.62 C ATOM 3344 CB VAL A 463 8.406 7.488 −0.847 1.00 42.42 C ATOM 3345 CG1 VAL A 463 7.360 8.553 −1.141 1.00 41.89 C ATOM 3346 CG2 VAL A 463 7.853 6.413 0.075 1.00 41.95 C ATOM 3347 C VAL A 463 10.333 6.270 −1.951 1.00 44.89 C ATOM 3348 O VAL A 463 10.569 5.098 −2.258 1.00 47.16 O ATOM 3349 N ALA A 464 11.254 7.076 −1.424 1.00 46.43 N ATOM 3350 CA ALA A 464 12.649 6.652 −1.221 1.00 48.09 C ATOM 3351 CB ALA A 464 13.531 7.856 −0.908 1.00 48.16 C ATOM 3352 C ALA A 464 12.818 5.567 −0.148 1.00 48.28 C ATOM 3353 O ALA A 464 12.032 5.490 0.803 1.00 48.89 O ATOM 3354 N HIS A 465 13.851 4.740 −0.325 1.00 48.04 N ATOM 3355 CA HIS A 465 14.234 3.673 0.625 1.00 47.71 C ATOM 3356 CB HIS A 465 14.487 4.231 2.026 1.00 48.77 C ATOM 3357 CG HIS A 465 15.465 5.373 2.049 1.00 50.45 C ATOM 3358 ND1 HIS A 465 16.795 5.187 1.977 1.00 50.15 N ATOM 3359 CE1 HIS A 465 17.415 6.381 2.011 1.00 51.50 C ATOM 3360 NE2 HIS A 465 16.475 7.338 2.102 1.00 52.03 N ATOM 3361 CD2 HIS A 465 15.262 6.752 2.125 1.00 51.41 C ATOM 3362 C HIS A 465 13.298 2.491 0.675 1.00 45.94 C ATOM 3363 O HIS A 465 12.982 1.988 1.759 1.00 43.12 O ATOM 3364 N GLN A 466 12.872 2.034 −0.508 1.00 45.45 N ATOM 3365 CA GLN A 466 12.072 0.809 −0.674 1.00 46.22 C ATOM 3366 CB GLN A 466 12.853 −0.427 −0.200 1.00 48.54 C ATOM 3367 CG GLN A 466 14.201 −0.623 −0.876 1.00 50.97 C ATOM 3368 CD GLN A 466 14.080 −0.724 −2.381 1.00 52.63 C ATOM 3369 OE1 GLN A 466 13.308 −1.535 −2.902 1.00 55.23 O ATOM 3370 NE2 GLN A 466 14.836 0.106 −3.092 1.00 52.56 N ATOM 3371 C GLN A 466 10.723 0.887 0.038 1.00 46.26 C ATOM 3372 O GLN A 466 10.270 −0.087 0.653 1.00 45.57 O ATOM 3373 N GLN A 467 10.080 2.048 −0.058 1.00 45.98 N ATOM 3374 CA GLN A 467 8.913 2.341 0.769 1.00 45.22 C ATOM 3375 CB GLN A 467 9.289 3.304 1.922 1.00 45.41 C ATOM 3376 CG GLN A 467 9.929 2.610 3.128 1.00 45.81 C ATOM 3377 CD GLN A 467 10.679 3.554 4.067 1.00 46.80 C ATOM 3378 OE1 GLN A 467 11.391 4.466 3.627 1.00 47.37 O ATOM 3379 NE2 GLN A 467 10.540 3.319 5.373 1.00 45.24 N ATOM 3380 C GLN A 467 7.706 2.855 −0.022 1.00 42.64 C ATOM 3381 O GLN A 467 7.765 3.020 −1.243 1.00 40.86 O ATOM 3382 N LEU A 468 6.623 3.103 0.710 1.00 40.59 N ATOM 3383 CA LEU A 468 5.345 3.511 0.162 1.00 39.02 C ATOM 3384 CB LEU A 468 4.432 2.292 0.132 1.00 38.48 C ATOM 3385 CG LEU A 468 3.674 1.981 −1.152 1.00 38.08 C ATOM 3386 CD1 LEU A 468 3.803 0.514 −1.526 1.00 37.26 C ATOM 3387 CD2 LEU A 468 2.222 2.347 −0.969 1.00 38.48 C ATOM 3388 C LEU A 468 4.772 4.604 1.076 1.00 38.80 C ATOM 3389 O LEU A 468 5.155 4.700 2.244 1.00 39.13 O ATOM 3390 N ILE A 469 3.875 5.438 0.557 1.00 38.69 N ATOM 3391 CA ILE A 469 3.339 6.547 1.364 1.00 40.51 C ATOM 3392 CB ILE A 469 4.198 7.833 1.203 1.00 40.72 C ATOM 3393 CG1 ILE A 469 3.862 8.856 2.296 1.00 40.12 C ATOM 3394 CD1 ILE A 469 4.883 9.965 2.439 1.00 41.82 C ATOM 3395 CG2 ILE A 469 4.037 8.429 −0.193 1.00 40.40 C ATOM 3396 C ILE A 469 1.848 6.863 1.127 1.00 40.60 C ATOM 3397 O ILE A 469 1.401 6.930 −0.011 1.00 41.16 O ATOM 3398 N GLN A 470 1.092 7.049 2.209 1.00 40.05 N ATOM 3399 CA GLN A 470 −0.277 7.546 2.111 1.00 40.97 C ATOM 3400 CB GLN A 470 −1.289 6.496 2.584 1.00 41.45 C ATOM 3401 CG GLN A 470 −2.718 7.028 2.686 1.00 42.48 C ATOM 3402 CD GLN A 470 −3.780 5.940 2.772 1.00 42.16 C ATOM 3403 OE1 GLN A 470 −4.821 6.017 2.116 1.00 41.81 O ATOM 3404 NE2 GLN A 470 −3.525 4.928 3.583 1.00 42.49 N ATOM 3405 C GLN A 470 −0.457 8.834 2.906 1.00 42.34 C ATOM 3406 O GLN A 470 −0.218 8.871 4.116 1.00 43.77 O ATOM 3407 N ILE A 471 −0.893 9.886 2.221 1.00 42.56 N ATOM 3408 CA ILE A 471 −1.186 11.158 2.873 1.00 43.72 C ATOM 3409 CB ILE A 471 −0.411 12.334 2.233 1.00 41.85 C ATOM 3410 CG1 ILE A 471 1.100 12.068 2.281 1.00 40.87 C ATOM 3411 CD1 ILE A 471 1.956 13.143 1.644 1.00 41.25 C ATOM 3412 CG2 ILE A 471 −0.753 13.639 2.937 1.00 41.97 C ATOM 3413 C ILE A 471 −2.693 11.431 2.864 1.00 47.17 C ATOM 3414 O ILE A 471 −3.258 11.850 1.843 1.00 47.50 O ATOM 3415 N THR A 472 −3.336 11.172 4.005 1.00 49.76 N ATOM 3416 CA THR A 472 −4.761 11.459 4.181 1.00 51.05 C ATOM 3417 CB THR A 472 −5.475 10.380 5.021 1.00 51.95 C ATOM 3418 OG1 THR A 472 −5.002 10.422 6.373 1.00 53.97 O ATOM 3419 CG2 THR A 472 −5.246 9.000 4.439 1.00 52.95 C ATOM 3420 C THR A 472 −4.980 12.817 4.845 1.00 52.07 C ATOM 3421 O THR A 472 −4.029 13.561 5.092 1.00 53.60 O ATOM 3422 N SER A 473 −6.243 13.134 5.117 1.00 53.15 N ATOM 3423 CA SER A 473 −6.601 14.318 5.889 1.00 52.33 C ATOM 3424 CB SER A 473 −8.114 14.556 5.845 1.00 52.39 C ATOM 3425 OG SER A 473 −8.822 13.329 5.763 1.00 52.07 O ATOM 3426 C SER A 473 −6.124 14.159 7.326 1.00 51.45 C ATOM 3427 O SER A 473 −5.639 15.114 7.935 1.00 53.87 O ATOM 3428 N ALA A 474 −6.240 12.941 7.851 1.00 48.94 N ATOM 3429 CA ALA A 474 −5.831 12.651 9.223 1.00 47.42 C ATOM 3430 CB ALA A 474 −6.409 11.322 9.689 1.00 46.79 C ATOM 3431 C ALA A 474 −4.315 12.672 9.408 1.00 45.15 C ATOM 3432 O ALA A 474 −3.801 13.460 10.195 1.00 46.18 O ATOM 3433 N SER A 475 −3.601 11.816 8.685 0.50 42.12 N ATOM 3434 CA SER A 475 −2.182 11.638 8.948 0.50 39.85 C ATOM 3435 CB SER A 475 −1.974 10.544 9.997 0.50 39.67 C ATOM 3436 OG SER A 475 −2.082 9.260 9.411 0.50 38.56 O ATOM 3437 C SER A 475 −1.372 11.315 7.707 0.50 38.46 C ATOM 3438 O SER A 475 −1.902 11.239 6.601 0.50 37.74 O ATOM 3439 N VAL A 476 −0.074 11.135 7.920 1.00 37.89 N ATOM 3440 CA VAL A 476 0.875 10.797 6.872 1.00 38.34 C ATOM 3441 CB VAL A 476 1.998 11.851 6.768 1.00 36.70 C ATOM 3442 CG1 VAL A 476 2.936 11.523 5.622 1.00 35.88 C ATOM 3443 CG2 VAL A 476 1.421 13.254 6.616 1.00 36.34 C ATOM 3444 C VAL A 476 1.492 9.448 7.221 1.00 39.87 C ATOM 3445 O VAL A 476 2.114 9.295 8.276 1.00 39.70 O ATOM 3446 N ARG A 477 1.322 8.474 6.332 1.00 41.86 N ATOM 3447 CA ARG A 477 1.707 7.100 6.632 1.00 43.96 C ATOM 3448 CB ARG A 477 0.499 6.148 6.530 1.00 44.71 C ATOM 3449 CG ARG A 477 −0.872 6.797 6.678 1.00 45.17 C ATOM 3450 CD ARG A 477 −1.736 6.095 7.718 1.00 46.37 C ATOM 3451 NE ARG A 477 −1.812 4.640 7.555 1.00 47.64 N ATOM 3452 CZ ARG A 477 −1.930 3.783 8.572 1.00 48.71 C ATOM 3453 NH1 ARG A 477 −1.965 4.234 9.818 1.00 49.09 N ATOM 3454 NH2 ARG A 477 −1.995 2.474 8.354 1.00 47.73 N ATOM 3455 C ARG A 477 2.852 6.584 5.753 1.00 45.51 C ATOM 3456 O ARG A 477 2.659 6.309 4.564 1.00 47.30 O ATOM 3457 N LEU A 478 4.036 6.447 6.347 1.00 44.67 N ATOM 3458 CA LEU A 478 5.134 5.730 5.709 1.00 44.78 C ATOM 3459 CB LEU A 478 6.472 6.165 6.305 1.00 45.87 C ATOM 3460 CG LEU A 478 7.767 5.627 5.690 1.00 47.04 C ATOM 3461 CD1 LEU A 478 7.959 6.133 4.267 1.00 49.23 C ATOM 3462 CD2 LEU A 478 8.962 6.001 6.553 1.00 47.18 C ATOM 3463 C LEU A 478 4.938 4.221 5.882 1.00 45.57 C ATOM 3464 O LEU A 478 4.718 3.739 6.997 1.00 47.86 O ATOM 3465 N VAL A 479 5.000 3.487 4.773 1.00 44.87 N ATOM 3466 CA VAL A 479 4.809 2.031 4.771 1.00 44.31 C ATOM 3467 CB VAL A 479 3.529 1.623 3.998 1.00 44.19 C ATOM 3468 CG1 VAL A 479 3.305 0.119 4.051 1.00 43.45 C ATOM 3469 CG2 VAL A 479 2.308 2.352 4.537 1.00 45.17 C ATOM 3470 C VAL A 479 5.999 1.382 4.092 1.00 44.49 C ATOM 3471 O VAL A 479 6.579 1.964 3.184 1.00 46.29 O ATOM 3472 N SER A 480 6.357 0.179 4.525 1.00 45.99 N ATOM 3473 CA SER A 480 7.426 −0.600 3.875 1.00 46.49 C ATOM 3474 CB SER A 480 8.190 −1.458 4.906 1.00 45.41 C ATOM 3475 OG SER A 480 7.313 −2.247 5.695 1.00 43.52 O ATOM 3476 C SER A 480 6.897 −1.450 2.701 1.00 45.43 C ATOM 3477 O SER A 480 5.699 −1.456 2.428 1.00 43.72 O ATOM 3478 N GLN A 481 7.797 −2.152 2.013 1.00 46.97 N ATOM 3479 CA GLN A 481 7.432 −2.968 0.852 1.00 50.05 C ATOM 3480 CB GLN A 481 8.371 −2.680 −0.320 1.00 49.01 C ATOM 3481 CG GLN A 481 8.068 −1.391 −1.064 1.00 48.30 C ATOM 3482 CD GLN A 481 7.014 −1.579 −2.127 1.00 48.18 C ATOM 3483 OE1 GLN A 481 5.838 −1.761 −1.825 1.00 49.19 O ATOM 3484 NE2 GLN A 481 7.433 −1.542 −3.386 1.00 47.73 N ATOM 3485 C GLN A 481 7.401 −4.468 1.151 1.00 54.21 C ATOM 3486 O GLN A 481 6.360 −5.113 1.004 1.00 55.66 O ATOM 3487 N GLU A 482 8.544 −5.022 1.552 1.00 60.09 N ATOM 3488 CA GLU A 482 8.633 −6.433 1.929 1.00 65.54 C ATOM 3489 CB GLU A 482 10.090 −6.912 1.894 1.00 70.05 C ATOM 3490 CG GLU A 482 10.262 −8.358 1.435 1.00 73.46 C ATOM 3491 CD GLU A 482 9.613 −8.637 0.085 1.00 73.86 C ATOM 3492 OE1 GLU A 482 10.146 −8.173 −0.946 1.00 74.14 O ATOM 3493 OE2 GLU A 482 8.573 −9.329 0.056 1.00 73.05 O ATOM 3494 C GLU A 482 8.008 −6.618 3.317 1.00 67.11 C ATOM 3495 O GLU A 482 8.390 −5.918 4.263 1.00 63.86 O ATOM 3496 N PRO A 483 7.102 −7.614 3.456 1.00 69.37 N ATOM 3497 CA PRO A 483 5.930 −7.529 4.316 1.00 69.18 C ATOM 3498 CB PRO A 483 6.330 −8.420 5.495 1.00 69.35 C ATOM 3499 CG PRO A 483 7.181 −9.492 4.839 1.00 69.68 C ATOM 3500 CD PRO A 483 7.572 −9.008 3.448 1.00 68.89 C ATOM 3501 C PRO A 483 5.520 −6.107 4.732 1.00 67.55 C ATOM 3502 O PRO A 483 6.143 −5.493 5.605 1.00 69.42 O ATOM 3503 N LYS A 484 4.468 −5.609 4.087 1.00 62.63 N ATOM 3504 CA LYS A 484 4.013 −4.229 4.243 1.00 60.33 C ATOM 3505 CB LYS A 484 2.902 −3.928 3.235 1.00 61.17 C ATOM 3506 CG LYS A 484 3.081 −4.603 1.887 1.00 61.40 C ATOM 3507 CD LYS A 484 2.206 −3.962 0.825 1.00 59.69 C ATOM 3508 CE LYS A 484 2.710 −4.293 −0.572 1.00 59.70 C ATOM 3509 NZ LYS A 484 4.047 −3.692 −0.856 1.00 57.22 N ATOM 3510 C LYS A 484 3.504 −3.941 5.650 1.00 58.82 C ATOM 3511 O LYS A 484 2.695 −4.693 6.192 1.00 58.60 O ATOM 3512 N ALA A 485 3.978 −2.842 6.230 1.00 56.63 N ATOM 3513 CA ALA A 485 3.540 −2.406 7.559 1.00 56.02 C ATOM 3514 CB ALA A 485 4.363 −3.092 8.641 1.00 57.14 C ATOM 3515 C ALA A 485 3.650 −0.893 7.697 1.00 54.62 C ATOM 3516 O ALA A 485 4.461 −0.263 7.021 1.00 54.89 O ATOM 3517 N LEU A 486 2.837 −0.316 8.577 1.00 53.13 N ATOM 3518 CA LEU A 486 2.918 1.112 8.873 1.00 52.85 C ATOM 3519 CB LEU A 486 1.649 1.574 9.601 1.00 54.48 C ATOM 3520 CG LEU A 486 1.682 2.926 10.330 1.00 55.55 C ATOM 3521 CD1 LEU A 486 1.587 4.103 9.365 1.00 54.60 C ATOM 3522 CD2 LEU A 486 0.592 2.987 11.393 1.00 55.64 C ATOM 3523 C LEU A 486 4.161 1.401 9.716 1.00 51.00 C ATOM 3524 O LEU A 486 4.091 1.430 10.942 1.00 52.35 O ATOM 3525 N VAL A 487 5.298 1.608 9.057 1.00 48.07 N ATOM 3526 CA VAL A 487 6.576 1.718 9.767 1.00 46.34 C ATOM 3527 CB VAL A 487 7.794 1.472 8.847 1.00 44.88 C ATOM 3528 CG1 VAL A 487 7.937 −0.012 8.538 1.00 43.47 C ATOM 3529 CG2 VAL A 487 7.698 2.292 7.567 1.00 45.56 C ATOM 3530 C VAL A 487 6.720 3.031 10.539 1.00 46.92 C ATOM 3531 O VAL A 487 7.319 3.064 11.620 1.00 47.97 O ATOM 3532 N SER A 488 6.153 4.100 9.989 1.00 46.30 N ATOM 3533 CA SER A 488 6.154 5.402 10.644 1.00 46.22 C ATOM 3534 CB SER A 488 7.335 6.250 10.167 1.00 46.58 C ATOM 3535 OG SER A 488 8.470 6.060 10.990 1.00 46.34 O ATOM 3536 C SER A 488 4.865 6.147 10.373 1.00 45.99 C ATOM 3537 O SER A 488 4.296 6.048 9.289 1.00 45.74 O ATOM 3538 N GLU A 489 4.405 6.891 11.367 1.00 47.69 N ATOM 3539 CA GLU A 489 3.295 7.801 11.162 1.00 50.28 C ATOM 3540 CB GLU A 489 2.022 7.301 11.852 1.00 50.98 C ATOM 3541 CG GLU A 489 0.764 8.050 11.424 1.00 53.85 C ATOM 3542 CD GLU A 489 −0.508 7.214 11.505 1.00 57.31 C ATOM 3543 OE1 GLU A 489 −1.587 7.797 11.754 1.00 58.63 O ATOM 3544 OE2 GLU A 489 −0.446 5.981 11.312 1.00 58.49 O ATOM 3545 C GLU A 489 3.656 9.202 11.628 1.00 52.15 C ATOM 3546 O GLU A 489 4.472 9.390 12.542 1.00 51.40 O ATOM 3547 N TRP A 490 3.057 10.181 10.963 1.00 53.45 N ATOM 3548 CA TRP A 490 3.202 11.571 11.328 1.00 55.27 C ATOM 3549 CB TRP A 490 4.105 12.275 10.340 1.00 54.50 C ATOM 3550 CG TRP A 490 4.388 13.707 10.689 1.00 55.57 C ATOM 3551 CD1 TRP A 490 5.524 14.218 11.305 1.00 56.92 C ATOM 3552 NE1 TRP A 490 5.432 15.580 11.447 1.00 57.95 N ATOM 3553 CE2 TRP A 490 4.263 16.033 10.947 1.00 57.40 C ATOM 3554 CD2 TRP A 490 3.533 14.871 10.439 1.00 56.18 C ATOM 3555 CE3 TRP A 490 2.283 15.060 9.866 1.00 56.86 C ATOM 3556 CZ3 TRP A 490 1.765 16.359 9.805 1.00 57.22 C ATOM 3557 CH2 TRP A 490 2.482 17.460 10.294 1.00 57.19 C ATOM 3558 CZ2 TRP A 490 3.745 17.317 10.876 1.00 57.88 C ATOM 3559 C TRP A 490 1.856 12.210 11.328 1.00 57.38 C ATOM 3560 O TRP A 490 1.081 12.052 10.383 1.00 58.08 O ATOM 3561 N LYS A 491 1.562 12.938 12.397 1.00 60.13 N ATOM 3562 CA LYS A 491 0.324 13.688 12.499 1.00 61.82 C ATOM 3563 CB LYS A 491 −0.686 12.944 13.377 1.00 63.77 C ATOM 3564 CG LYS A 491 −2.134 13.335 13.123 1.00 66.80 C ATOM 3565 CD LYS A 491 −3.103 12.237 13.542 1.00 68.86 C ATOM 3566 CE LYS A 491 −4.535 12.598 13.164 1.00 68.89 C ATOM 3567 NZ LYS A 491 −5.450 11.421 13.159 1.00 68.88 N ATOM 3568 C LYS A 491 0.651 15.051 13.078 1.00 62.09 C ATOM 3569 O LYS A 491 1.706 15.228 13.696 1.00 61.56 O ATOM 3570 N GLU A 492 −0.239 16.017 12.861 1.00 62.70 N ATOM 3571 CA GLU A 492 −0.069 17.349 13.428 1.00 62.29 C ATOM 3572 CB GLU A 492 −1.194 18.279 12.972 1.00 63.77 C ATOM 3573 CG GLU A 492 −0.838 19.756 13.076 1.00 64.15 C ATOM 3574 CD GLU A 492 −1.962 20.598 13.645 1.00 65.90 C ATOM 3575 OE1 GLU A 492 −2.796 20.054 14.399 1.00 67.37 O ATOM 3576 OE2 GLU A 492 −2.005 21.809 13.346 1.00 66.21 O ATOM 3577 C GLU A 492 −0.047 17.270 14.954 1.00 60.81 C ATOM 3578 O GLU A 492 −0.824 16.513 15.537 1.00 59.93 O ATOM 3579 N PRO A 493 0.865 18.032 15.600 1.00 60.19 N ATOM 3580 CA PRO A 493 0.913 18.164 17.056 1.00 58.70 C ATOM 3581 CB PRO A 493 1.816 19.378 17.253 1.00 57.99 C ATOM 3582 CG PRO A 493 2.790 19.277 16.126 1.00 58.14 C ATOM 3583 CD PRO A 493 2.050 18.652 14.968 1.00 59.51 C ATOM 3584 C PRO A 493 −0.453 18.388 17.722 1.00 59.19 C ATOM 3585 O PRO A 493 −0.708 17.822 18.786 1.00 60.05 O ATOM 3586 N GLN A 494 −1.322 19.185 17.101 1.00 59.58 N ATOM 3587 CA GLN A 494 −2.667 19.424 17.643 1.00 60.94 C ATOM 3588 CB GLN A 494 −3.073 20.890 17.457 1.00 60.26 C ATOM 3589 C GLN A 494 −3.743 18.486 17.066 1.00 62.53 C ATOM 3590 O GLN A 494 −4.939 18.703 17.277 1.00 61.69 O ATOM 3591 N ALA A 495 −3.304 17.448 16.349 1.00 64.58 N ATOM 3592 CA ALA A 495 −4.191 16.424 15.762 1.00 65.33 C ATOM 3593 CB ALA A 495 −4.767 15.519 16.853 1.00 63.92 C ATOM 3594 C ALA A 495 −5.308 16.989 14.865 1.00 67.00 C ATOM 3595 O ALA A 495 −6.460 16.544 14.936 1.00 68.46 O ATOM 3596 N LYS A 496 −4.955 17.953 14.014 1.00 66.19 N ATOM 3597 CA LYS A 496 −5.934 18.641 13.164 1.00 64.61 C ATOM 3598 CB LYS A 496 −5.618 20.138 13.071 1.00 65.20 C ATOM 3599 CG LYS A 496 −6.063 20.961 14.272 1.00 64.12 C ATOM 3600 CD LYS A 496 −6.391 22.392 13.867 1.00 64.40 C ATOM 3601 CE LYS A 496 −7.710 22.467 13.103 1.00 64.90 C ATOM 3602 NZ LYS A 496 −7.916 23.787 12.444 1.00 63.91 N ATOM 3603 C LYS A 496 −6.036 18.045 11.760 1.00 64.34 C ATOM 3604 O LYS A 496 −5.183 17.254 11.348 1.00 65.48 O ATOM 3605 N ASN A 497 −7.087 18.445 11.037 1.00 62.34 N ATOM 3606 CA ASN A 497 −7.348 17.998 9.663 1.00 58.45 C ATOM 3607 CB ASN A 497 −8.828 18.216 9.298 1.00 56.77 C ATOM 3608 CG ASN A 497 −9.744 17.125 9.845 1.00 56.46 C ATOM 3609 OD1 ASN A 497 −9.463 16.512 10.876 1.00 56.68 O ATOM 3610 ND2 ASN A 497 −10.855 16.885 9.152 1.00 54.70 N ATOM 3611 C ASN A 497 −6.454 18.698 8.638 1.00 56.98 C ATOM 3612 O ASN A 497 −6.468 19.927 8.535 1.00 57.10 O ATOM 3613 N ILE A 498 −5.681 17.906 7.891 1.00 54.60 N ATOM 3614 CA ILE A 498 −4.803 18.415 6.826 1.00 53.19 C ATOM 3615 CB ILE A 498 −3.786 17.336 6.351 1.00 51.98 C ATOM 3616 CG1 ILE A 498 −2.788 17.000 7.467 1.00 49.61 C ATOM 3617 CD1 ILE A 498 −1.808 15.897 7.117 1.00 47.94 C ATOM 3618 CG2 ILE A 498 −3.041 17.789 5.097 1.00 52.15 C ATOM 3619 C ILE A 498 −5.634 18.943 5.646 1.00 52.27 C ATOM 3620 O ILE A 498 −6.584 18.287 5.205 1.00 51.27 O ATOM 3621 N SER A 499 −5.274 20.130 5.150 1.00 51.59 N ATOM 3622 CA SER A 499 −6.035 20.796 4.081 1.00 52.00 C ATOM 3623 CB SER A 499 −6.270 22.291 4.396 1.00 50.60 C ATOM 3624 OG SER A 499 −5.058 23.025 4.508 1.00 48.04 O ATOM 3625 C SER A 499 −5.452 20.601 2.670 1.00 52.90 C ATOM 3626 O SER A 499 −6.211 20.485 1.703 1.00 55.16 O ATOM 3627 N VAL A 500 −4.119 20.586 2.556 1.00 52.51 N ATOM 3628 CA VAL A 500 −3.425 20.332 1.278 1.00 50.20 C ATOM 3629 CB VAL A 500 −3.117 21.629 0.494 1.00 51.08 C ATOM 3630 CG1 VAL A 500 −2.847 21.297 −0.966 1.00 54.06 C ATOM 3631 CG2 VAL A 500 −4.251 22.639 0.597 1.00 50.55 C ATOM 3632 C VAL A 500 −2.099 19.600 1.504 1.00 48.27 C ATOM 3633 O VAL A 500 −1.410 19.856 2.491 1.00 48.00 O ATOM 3634 N ALA A 501 −1.743 18.705 0.581 1.00 47.33 N ATOM 3635 CA ALA A 501 −0.485 17.943 0.668 1.00 49.38 C ATOM 3636 CB ALA A 501 −0.763 16.511 1.090 1.00 47.41 C ATOM 3637 C ALA A 501 0.322 17.963 −0.639 1.00 51.85 C ATOM 3638 O ALA A 501 −0.229 18.230 −1.711 1.00 55.82 O ATOM 3639 N SER A 502 1.624 17.678 −0.537 1.00 51.54 N ATOM 3640 CA SER A 502 2.521 17.589 −1.702 1.00 51.51 C ATOM 3641 CB SER A 502 2.912 18.981 −2.201 1.00 53.38 C ATOM 3642 OG SER A 502 3.557 19.726 −1.181 1.00 54.00 O ATOM 3643 C SER A 502 3.777 16.792 −1.360 1.00 50.43 C ATOM 3644 O SER A 502 4.393 17.013 −0.317 1.00 50.95 O ATOM 3645 N CYS A 503 4.166 15.881 −2.248 1.00 48.30 N ATOM 3646 CA CYS A 503 5.206 14.911 −1.924 1.00 48.04 C ATOM 3647 CB CYS A 503 4.616 13.816 −1.039 1.00 45.41 C ATOM 3648 SG CYS A 503 5.588 12.305 −1.018 1.00 45.78 S ATOM 3649 C CYS A 503 5.898 14.287 −3.144 1.00 49.28 C ATOM 3650 O CYS A 503 5.268 13.598 −3.944 1.00 53.69 O ATOM 3651 N ASN A 504 7.200 14.514 −3.271 1.00 48.14 N ATOM 3652 CA ASN A 504 7.976 13.892 −4.334 1.00 47.83 C ATOM 3653 CB ASN A 504 9.058 14.853 −4.858 1.00 49.77 C ATOM 3654 CG ASN A 504 9.924 15.442 −3.751 1.00 50.36 C ATOM 3655 OD1 ASN A 504 9.952 14.946 −2.627 1.00 51.24 O ATOM 3656 ND2 ASN A 504 10.639 16.507 −4.075 1.00 50.20 N ATOM 3657 C ASN A 504 8.584 12.555 −3.901 1.00 48.68 C ATOM 3658 O ASN A 504 7.980 11.813 −3.119 1.00 47.31 O ATOM 3659 N SER A 505 9.784 12.265 −4.402 1.00 48.90 N ATOM 3660 CA SER A 505 10.473 11.010 −4.121 1.00 49.84 C ATOM 3661 CB SER A 505 11.678 10.855 −5.051 1.00 49.73 C ATOM 3662 OG SER A 505 12.035 9.495 −5.204 1.00 48.86 O ATOM 3663 C SER A 505 10.917 10.904 −2.661 1.00 52.35 C ATOM 3664 O SER A 505 10.938 9.809 −2.094 1.00 53.28 O ATOM 3665 N SER A 506 11.262 12.045 −2.062 1.00 54.98 N ATOM 3666 CA SER A 506 11.773 12.097 −0.687 1.00 55.98 C ATOM 3667 CB SER A 506 13.234 12.545 −0.671 1.00 54.37 C ATOM 3668 OG SER A 506 13.843 12.371 −1.936 1.00 55.05 O ATOM 3669 C SER A 506 10.959 13.045 0.191 1.00 58.34 C ATOM 3670 O SER A 506 10.426 12.647 1.221 1.00 60.81 O ATOM 3671 N GLN A 507 10.863 14.300 −0.230 1.00 59.81 N ATOM 3672 CA GLN A 507 10.294 15.359 0.603 1.00 61.33 C ATOM 3673 CB GLN A 507 10.862 16.711 0.171 1.00 62.96 C ATOM 3674 CG GLN A 507 12.380 16.791 0.248 1.00 62.04 C ATOM 3675 CD GLN A 507 12.981 17.544 −0.917 1.00 61.90 C ATOM 3676 OE1 GLN A 507 12.754 17.194 −2.077 1.00 60.65 O ATOM 3677 NE2 GLN A 507 13.758 18.582 −0.618 1.00 60.82 N ATOM 3678 C GLN A 507 8.754 15.399 0.623 1.00 61.25 C ATOM 3679 O GLN A 507 8.090 15.014 −0.345 1.00 59.65 O ATOM 3680 N VAL A 508 8.209 15.865 1.747 1.00 58.81 N ATOM 3681 CA VAL A 508 6.770 16.021 1.933 1.00 57.70 C ATOM 3682 CB VAL A 508 6.217 14.992 2.947 1.00 58.51 C ATOM 3683 CG1 VAL A 508 4.740 15.247 3.237 1.00 57.30 C ATOM 3684 CG2 VAL A 508 6.433 13.567 2.450 1.00 59.50 C ATOM 3685 C VAL A 508 6.495 17.423 2.462 1.00 56.84 C ATOM 3686 O VAL A 508 7.155 17.871 3.397 1.00 59.52 O ATOM 3687 N VAL A 509 5.535 18.118 1.857 1.00 54.93 N ATOM 3688 CA VAL A 509 5.107 19.426 2.359 1.00 54.53 C ATOM 3689 CB VAL A 509 5.614 20.603 1.491 1.00 53.47 C ATOM 3690 CG1 VAL A 509 5.102 21.933 2.032 1.00 52.06 C ATOM 3691 CG2 VAL A 509 7.135 20.613 1.432 1.00 53.02 C ATOM 3692 C VAL A 509 3.591 19.472 2.506 1.00 54.33 C ATOM 3693 O VAL A 509 2.854 19.537 1.521 1.00 51.21 O ATOM 3694 N VAL A 510 3.144 19.436 3.755 1.00 58.04 N ATOM 3695 CA VAL A 510 1.723 19.372 4.077 1.00 61.77 C ATOM 3696 CB VAL A 510 1.386 18.168 4.992 1.00 60.26 C ATOM 3697 CG1 VAL A 510 1.391 16.873 4.191 1.00 58.84 C ATOM 3698 CG2 VAL A 510 2.348 18.089 6.174 1.00 58.78 C ATOM 3699 C VAL A 510 1.224 20.664 4.716 1.00 64.58 C ATOM 3700 O VAL A 510 1.818 21.172 5.672 1.00 65.43 O ATOM 3701 N ALA A 511 0.131 21.188 4.172 1.00 66.78 N ATOM 3702 CA ALA A 511 −0.506 22.377 4.711 1.00 67.46 C ATOM 3703 CB ALA A 511 −1.033 23.247 3.584 1.00 67.71 C ATOM 3704 C ALA A 511 −1.632 21.988 5.659 1.00 69.37 C ATOM 3705 O ALA A 511 −2.420 21.080 5.364 1.00 67.83 O ATOM 3706 N VAL A 512 −1.684 22.661 6.809 1.00 70.63 N ATOM 3707 CA VAL A 512 −2.785 22.495 7.762 1.00 69.14 C ATOM 3708 CB VAL A 512 −2.325 21.863 9.104 1.00 66.23 C ATOM 3709 CG1 VAL A 512 −3.528 21.440 9.934 1.00 65.55 C ATOM 3710 CG2 VAL A 512 −1.423 20.660 8.859 1.00 64.84 C ATOM 3711 C VAL A 512 −3.480 23.845 7.988 1.00 68.59 C ATOM 3712 O VAL A 512 −3.208 24.542 8.965 1.00 67.13 O ATOM 3713 N GLY A 513 −4.351 24.210 7.045 1.00 70.74 N ATOM 3714 CA GLY A 513 −5.172 25.421 7.127 1.00 68.37 C ATOM 3715 C GLY A 513 −4.409 26.733 7.098 1.00 67.79 C ATOM 3716 O GLY A 513 −4.441 27.457 6.103 1.00 66.74 O ATOM 3717 N ARG A 514 −3.723 27.028 8.202 1.00 69.00 N ATOM 3718 CA ARG A 514 −3.109 28.336 8.445 1.00 69.52 C ATOM 3719 CB ARG A 514 −3.434 28.801 9.877 1.00 66.66 C ATOM 3720 CG ARG A 514 −3.336 30.303 10.120 1.00 65.18 C ATOM 3721 CD ARG A 514 −4.030 30.685 11.424 1.00 63.83 C ATOM 3722 NE ARG A 514 −3.580 31.976 11.955 1.00 62.51 N ATOM 3723 CZ ARG A 514 −3.949 32.487 13.134 1.00 61.32 C ATOM 3724 NH1 ARG A 514 −4.785 31.828 13.928 1.00 60.42 N ATOM 3725 NH2 ARG A 514 −3.479 33.667 13.524 1.00 59.28 N ATOM 3726 C ARG A 514 −1.591 28.317 8.209 1.00 70.88 C ATOM 3727 O ARG A 514 −1.029 29.275 7.670 1.00 69.40 O ATOM 3728 N ALA A 515 −0.944 27.220 8.613 1.00 70.64 N ATOM 3729 CA ALA A 515 0.512 27.064 8.506 1.00 67.99 C ATOM 3730 CB ALA A 515 1.164 27.313 9.851 1.00 68.73 C ATOM 3731 C ALA A 515 0.881 25.676 7.988 1.00 66.45 C ATOM 3732 O ALA A 515 0.115 24.725 8.152 1.00 66.98 O ATOM 3733 N LEU A 516 2.059 25.561 7.375 1.00 64.91 N ATOM 3734 CA LEU A 516 2.464 24.319 6.694 1.00 62.81 C ATOM 3735 CB LEU A 516 2.425 24.488 5.164 1.00 62.85 C ATOM 3736 CG LEU A 516 2.792 25.822 4.504 1.00 61.64 C ATOM 3737 CD1 LEU A 516 4.293 25.964 4.344 1.00 59.47 C ATOM 3738 CD2 LEU A 516 2.105 25.940 3.151 1.00 62.69 C ATOM 3739 C LEU A 516 3.813 23.751 7.141 1.00 60.12 C ATOM 3740 O LEU A 516 4.736 24.497 7.474 1.00 61.15 O ATOM 3741 N TYR A 517 3.916 22.423 7.124 1.00 57.39 N ATOM 3742 CA TYR A 517 5.097 21.718 7.622 1.00 57.13 C ATOM 3743 CB TYR A 517 4.702 20.709 8.704 1.00 56.31 C ATOM 3744 CG TYR A 517 3.826 21.271 9.806 1.00 56.16 C ATOM 3745 CD2 TYR A 517 2.436 21.205 9.715 1.00 55.27 C ATOM 3746 CE2 TYR A 517 1.630 21.711 10.720 1.00 54.05 C ATOM 3747 CZ TYR A 517 2.209 22.285 11.837 1.00 51.62 C ATOM 3748 OH TYR A 517 1.396 22.781 12.821 1.00 49.86 O ATOM 3749 CE1 TYR A 517 3.585 22.361 11.959 1.00 51.95 C ATOM 3750 CD1 TYR A 517 4.387 21.852 10.950 1.00 53.89 C ATOM 3751 C TYR A 517 5.878 20.992 6.525 1.00 57.53 C ATOM 3752 O TYR A 517 5.293 30.399 5.618 1.00 57.77 O ATOM 3753 N TYR A 518 7.202 21.032 6.636 1.00 57.24 N ATOM 3754 CA TYR A 518 8.086 20.290 5.744 1.00 57.41 C ATOM 3755 CB TYR A 518 9.285 21.158 5.348 1.00 59.37 C ATOM 3756 CG TYR A 518 10.410 20.405 4.671 1.00 61.22 C ATOM 3757 CD1 TYR A 518 10.246 19.852 3.397 1.00 61.96 C ATOM 3758 CE1 TYR A 518 11.278 19.165 2.774 1.00 62.58 C ATOM 3759 CZ TYR A 518 12.495 19.025 3.425 1.00 63.95 C ATOM 3760 OH TYR A 518 13.525 18.345 2.818 1.00 62.48 O ATOM 3761 CE2 TYR A 518 12.681 19.564 4.688 1.00 64.28 C ATOM 3762 CD2 TYR A 518 11.642 20.249 5.301 1.00 62.87 C ATOM 3763 C TYR A 518 8.551 18.985 6.396 1.00 56.78 C ATOM 3764 O TYR A 518 8.907 18.965 7.577 1.00 58.28 O ATOM 3765 N LEU A 519 8.541 17.903 5.620 1.00 54.27 N ATOM 3766 CA LEU A 519 8.902 16.573 6.115 1.00 53.09 C ATOM 3767 CB LEU A 519 7.642 15.752 6.397 1.00 53.58 C ATOM 3768 CG LEU A 519 6.867 15.875 7.716 1.00 53.00 C ATOM 3769 CD1 LEU A 519 5.975 17.110 7.767 1.00 52.65 C ATOM 3770 CD2 LEU A 519 6.027 14.620 7.885 1.00 51.44 C ATOM 3771 C LEU A 519 9.784 15.818 5.120 1.00 52.93 C ATOM 3772 O LEU A 519 9.689 16.032 3.911 1.00 51.85 O ATOM 3773 N GLN A 520 10.631 14.928 5.638 1.00 53.61 N ATOM 3774 CA GLN A 520 11.534 14.120 4.807 1.00 53.62 C ATOM 3775 CB GLN A 520 12.987 14.402 5.167 1.00 52.40 C ATOM 3776 CG GLN A 520 13.466 15.762 4.708 1.00 52.52 C ATOM 3777 CD GLN A 520 14.945 15.782 4.399 1.00 51.82 C ATOM 3778 OE1 GLN A 520 15.778 15.514 5.267 1.00 51.59 O ATOM 3779 NE2 GLN A 520 15.282 16.107 3.157 1.00 50.02 N ATOM 3780 C GLN A 520 11.260 12.627 4.941 1.00 55.81 C ATOM 3781 O GLN A 520 10.516 12.208 5.826 1.00 59.83 O ATOM 3782 N ILE A 521 11.857 11.829 4.056 1.00 55.06 N ATOM 3783 CA ILE A 521 11.708 10.371 4.111 1.00 54.44 C ATOM 3784 CB ILE A 521 10.855 9.807 2.939 1.00 54.67 C ATOM 3785 CG1 ILE A 521 9.433 10.386 2.976 1.00 54.63 C ATOM 3786 CD1 ILE A 521 8.664 10.261 1.675 1.00 51.62 C ATOM 3787 CG2 ILE A 521 10.797 8.277 2.989 1.00 53.85 C ATOM 3788 C ILE A 521 13.067 9.671 4.183 1.00 54.11 C ATOM 3789 O ILE A 521 13.871 9.731 3.244 1.00 52.80 O ATOM 3790 N HIS A 522 13.303 9.017 5.318 1.00 53.64 N ATOM 3791 CA HIS A 522 14.501 8.216 5.549 1.00 53.87 C ATOM 3792 CB HIS A 522 15.383 8.887 6.600 1.00 53.96 C ATOM 3793 CG HIS A 522 15.871 10.262 6.195 1.00 54.41 C ATOM 3794 ND1 HIS A 522 17.090 10.471 5.665 1.00 53.90 N ATOM 3795 CE1 HIS A 522 17.241 11.781 5.395 1.00 53.53 C ATOM 3796 NE2 HIS A 522 16.111 12.414 5.749 1.00 52.94 N ATOM 3797 CD2 HIS A 522 15.245 11.509 6.245 1.00 53.93 C ATOM 3798 C HIS A 522 14.068 6.842 5.992 1.00 53.83 C ATOM 3799 O HIS A 522 12.934 6.679 6.450 1.00 54.00 O ATOM 3800 N PRO A 523 14.949 5.822 5.853 1.00 53.25 N ATOM 3801 CA PRO A 523 14.532 4.454 6.180 1.00 52.11 C ATOM 3802 CB PRO A 523 15.857 3.695 6.254 1.00 51.48 C ATOM 3803 CG PRO A 523 16.739 4.417 5.305 1.00 52.15 C ATOM 3804 CD PRO A 523 16.359 5.870 5.419 1.00 53.12 C ATOM 3805 C PRO A 523 13.806 4.381 7.515 1.00 51.22 C ATOM 3806 O PRO A 523 14.285 4.939 8.500 1.00 51.50 O ATOM 3807 N GLN A 524 12.641 3.730 7.521 1.00 51.33 N ATOM 3808 CA GLN A 524 11.821 3.523 8.731 1.00 51.10 C ATOM 3809 CB GLN A 524 12.606 2.763 9.821 1.00 51.35 C ATOM 3810 CG GLN A 524 12.370 1.255 9.855 1.00 50.89 C ATOM 3811 CD GLN A 524 12.636 0.562 8.526 1.00 49.98 C ATOM 3812 OE1 GLN A 524 13.535 0.946 7.771 1.00 48.99 O ATOM 3813 NE2 GLN A 524 11.856 −0.475 8.240 1.00 49.37 N ATOM 3814 C GLN A 524 11.166 4.773 9.324 1.00 50.83 C ATOM 3815 O GLN A 524 10.173 4.657 10.042 1.00 49.18 O ATOM 3816 N GLU A 525 11.711 5.954 9.026 1.00 51.79 N ATOM 3817 CA GLU A 525 11.243 7.203 9.645 1.00 52.88 C ATOM 3818 CB GLU A 525 12.258 7.731 10.681 1.00 52.98 C ATOM 3819 CG GLU A 525 13.634 8.081 10.115 1.00 54.73 C ATOM 3820 CE GLU A 525 14.325 9.222 10.853 1.00 55.57 C ATOM 3821 OE1 GLU A 525 13.794 10.355 10.847 1.00 56.35 O ATOM 3822 OE2 GLU A 525 15.419 8.996 11.414 1.00 54.61 O ATOM 3823 C GLU A 525 10.882 8.315 8.656 1.00 53.04 C ATOM 3824 O GLU A 525 11.524 8.485 7.618 1.00 51.31 O ATOM 3825 N LEU A 526 9.830 9.054 8.992 1.00 54.98 N ATOM 3826 CA LEU A 526 9.582 10.369 8.411 1.00 56.40 C ATOM 3827 CB LEU A 526 8.282 10.409 7.587 1.00 56.34 C ATOM 3828 CG LEU A 526 7.060 9.513 7.843 1.00 55.47 C ATOM 3829 CD1 LEU A 526 6.441 9.694 9.222 1.00 54.64 C ATOM 3830 CD2 LEU A 526 6.023 9.772 6.759 1.00 54.25 C ATOM 3831 C LEU A 526 9.553 11.413 9.521 1.00 59.02 C ATOM 3832 O LEU A 526 8.530 11.591 10.192 1.00 61.20 O ATOM 3833 N ARG A 527 10.684 12.080 9.738 1.00 58.87 N ATOM 3834 CA ARG A 527 10.754 13.106 10.773 1.00 57.45 C ATOM 3835 CB ARG A 527 11.986 12.921 11.676 1.00 57.43 C ATOM 3836 CG ARG A 527 11.689 12.964 13.181 1.00 57.48 C ATOM 3837 CD ARG A 527 11.089 11.655 13.707 1.00 57.53 C ATOM 3838 NE ARG A 527 9.637 11.567 13.493 1.00 59.21 N ATOM 3839 CZ ARG A 527 8.973 10.448 13.483 1.00 59.40 C ATOM 3840 NH1 ARG A 527 9.618 9.296 13.036 1.00 60.39 N ATOM 3841 NH2 ARG A 527 7.655 10.482 13.004 1.00 57.61 N ATOM 3842 C ARG A 527 10.707 14.494 10.154 1.00 56.24 C ATOM 3843 O ARG A 527 11.180 14.707 9.034 1.00 55.42 O ATOM 3844 N GLN A 528 10.105 15.424 10.892 1.00 56.15 N ATOM 3845 CA GLN A 528 9.889 16.795 10.442 1.00 56.71 C ATOM 3846 CB GLN A 528 9.006 17.518 11.463 1.00 55.34 C ATOM 3847 CG GLN A 528 8.300 18.752 10.934 1.00 55.15 C ATOM 3848 CD GLN A 528 7.334 19.343 11.939 1.00 55.23 C ATOM 3849 OE1 GLN A 528 6.575 18.623 12.589 1.00 55.39 O ATOM 3850 NE2 GLN A 528 7.353 20.665 12.068 1.00 55.90 N ATOM 3851 C GLN A 528 11.220 17.540 10.271 1.00 57.49 C ATOM 3852 O GLN A 528 12.283 17.000 10.587 1.00 59.51 O ATOM 3853 N ILE A 529 11.153 18.768 9.752 1.00 56.75 N ATOM 3854 CA ILE A 529 12.312 19.672 9.720 1.00 56.24 C ATOM 3855 CB ILE A 529 13.145 19.513 8.421 1.00 54.62 C ATOM 3856 CG1 ILE A 529 14.112 18.334 8.556 1.00 52.36 C ATOM 3857 CD1 ILE A 529 14.760 17.903 7.259 1.00 51.53 C ATOM 3858 CG2 ILE A 529 13.925 20.786 8.106 1.00 54.49 C ATOM 3859 C ILE A 529 11.906 21.136 9.971 1.00 57.63 C ATOM 3860 O ILE A 529 12.495 21.814 10.822 1.00 59.60 O ATOM 3861 N SER A 530 10.886 21.603 9.253 1.00 57.58 N ATOM 3862 CA SER A 530 10.455 22.999 9.341 1.00 58.22 C ATOM 3863 CB SER A 530 10.622 23.693 7.990 1.00 58.25 C ATOM 3864 OG SER A 530 11.895 23.434 7.427 1.00 58.13 O ATOM 3865 C SER A 530 9.010 23.146 9.818 1.00 59.25 C ATOM 3866 O SER A 530 8.201 22.231 9.671 1.00 59.85 O ATOM 3867 N HIS A 531 8.703 24.309 10.388 1.00 60.56 N ATOM 3868 CA HIS A 531 7.356 24.643 10.856 1.00 62.22 C ATOM 3869 CB HIS A 531 7.127 24.147 12.292 1.00 60.25 C ATOM 3870 CG HIS A 531 8.387 24.091 13.134 1.00 58.01 C ATOM 3871 ND1 HIS A 531 9.167 22.994 13.199 1.00 57.16 N ATOM 3872 CE1 HIS A 531 10.211 23.232 14.010 1.00 55.98 C ATOM 3873 NE2 HIS A 531 10.100 24.487 14.473 1.00 56.15 N ATOM 3874 CD2 HIS A 531 8.987 25.045 13.952 1.00 57.01 C ATOM 3875 C HIS A 531 7.159 26.127 10.760 1.00 64.89 C ATOM 3876 O HIS A 531 7.709 26.884 11.564 1.00 66.97 O ATOM 3877 N THR A 532 6.377 26.561 9.769 1.00 66.97 N ATOM 3878 CA THR A 532 6.242 27.990 9.459 1.00 68.99 C ATOM 3879 CB THR A 532 6.636 28.279 7.998 1.00 68.42 C ATOM 3880 OG1 THR A 532 7.472 27.221 7.517 1.00 69.92 O ATOM 3881 CG2 THR A 532 7.384 29.608 7.890 1.00 67.56 C ATOM 3882 C THR A 532 4.838 28.541 9.753 1.00 71.44 C ATOM 3883 O THR A 532 4.092 27.958 10.541 1.00 72.27 O ATOM 3884 N GLU A 533 4.501 29.675 9.133 1.00 73.26 N ATOM 3885 CA GLU A 533 3.215 30.346 9.344 1.00 74.57 C ATOM 3886 CB GLU A 533 3.275 31.259 10.581 1.00 75.29 C ATOM 3887 CG GLU A 533 2.116 31.092 11.563 1.00 75.10 C ATOM 3888 CD GLU A 533 0.748 31.213 10.911 1.00 76.06 C ATOM 3889 OE1 GLU A 533 −0.046 30.252 11.008 1.00 74.65 O ATOM 3890 OE2 GLU A 533 0.468 32.261 10.292 1.00 77.25 O ATOM 3891 C GLU A 533 2.833 31.159 8.105 1.00 73.20 C ATOM 3892 O GLU A 533 3.687 31.811 7.496 1.00 71.42 O ATOM 3893 N MET A 534 1.551 31.127 7.745 1.00 72.95 N ATOM 3894 CA MET A 534 1.088 31.759 6.507 1.00 72.02 C ATOM 3895 CB MET A 534 0.459 30.715 5.576 1.00 71.34 C ATOM 3896 CG MET A 534 0.971 30.777 4.149 1.00 71.17 C ATOM 3897 SD MET A 534 2.732 30.392 4.058 1.00 73.00 S ATOM 3898 CE MET A 534 3.171 31.047 2.449 1.00 70.93 C ATOM 3899 C MET A 534 0.119 32.923 6.737 1.00 70.54 C ATOM 3900 O MET A 534 −0.771 32.851 7.594 1.00 70.27 O ATOM 3901 N GLU A 535 0.302 33.987 2.958 1.00 67.00 N ATOM 3902 CA GLU A 535 −0.577 35.153 6.000 1.00 64.93 C ATOM 3903 CB GLU A 535 0.163 36.397 5.498 1.00 62.90 C ATOM 3904 C GLU A 535 −1.841 34.920 5.171 1.00 63.32 C ATOM 3905 O GLU A 535 −2.674 34.073 5.503 1.00 60.76 O ATOM 3906 N VAL A 538 −3.872 28.903 2.551 1.00 68.23 N ATOM 3907 CA VAL A 538 −3.153 28.019 1.633 1.00 69.94 C ATOM 3908 CB VAL A 538 −1.989 27.271 2.339 1.00 70.92 C ATOM 3909 CG1 VAL A 538 −2.463 26.599 3.624 1.00 71.65 C ATOM 3910 CG2 VAL A 538 −1.320 26.272 1.399 1.00 69.92 C ATOM 3911 C VAL A 538 −4.110 27.050 0.934 1.00 69.95 C ATOM 3912 O VAL A 538 −4.903 26.364 1.586 1.00 70.70 O ATOM 3913 N ALA A 539 −4.023 26.999 −0.394 1.00 68.15 N ATOM 3914 CA ALA A 539 −5.002 26.280 −1.210 1.00 67.46 C ATOM 3915 CB ALA A 539 −5.811 27.266 −2.047 1.00 66.43 C ATOM 3916 C ALA A 539 −4.404 25.173 −2.098 1.00 66.14 C ATOM 3917 O ALA A 539 −5.141 24.335 −2.628 1.00 65.94 O ATOM 3918 N CYS A 540 −3.080 25.176 −2.258 1.00 64.53 N ATOM 3919 CA CYS A 540 −2.391 24.176 −3.083 1.00 62.51 C ATOM 3920 CB CYS A 540 −2.718 24.381 −4.555 1.00 62.19 C ATOM 3921 SG CYS A 540 −2.459 26.081 −5.086 1.00 63.95 S ATOM 3922 C CYS A 540 −0.881 24.214 −2.884 1.00 62.38 C ATOM 3923 O CYS A 540 −0.316 25.256 −2.532 1.00 61.78 O ATOM 3924 N LEU A 541 −0.233 23.076 −3.122 1.00 60.51 N ATOM 3925 CA LEU A 541 1.208 22.947 −2.907 1.00 60.74 C ATOM 3926 CB LEU A 541 1.485 22.171 −1.619 1.00 60.85 C ATOM 3927 CG LEU A 541 1.252 22.842 −0.270 1.00 62.23 C ATOM 3928 CD1 LEU A 541 1.035 21.785 0.802 1.00 61.89 C ATOM 3929 CD2 LEU A 541 2.416 23.751 0.088 1.00 61.57 C ATOM 3930 C LEU A 541 1.895 22.244 −4.071 1.00 59.87 C ATOM 3931 O LEU A 541 1.231 21.608 −4.893 1.00 60.03 O ATOM 3932 N ASP A 542 3.224 22.371 −4.133 1.00 58.60 N ATOM 3933 CA ASP A 542 4.053 21.582 −5.054 1.00 56.91 C ATOM 3934 CB ASP A 542 3.874 22.036 −6.501 1.00 55.92 C ATOM 3935 CG ASP A 542 4.322 20.986 −7.484 1.00 56.55 C ATOM 3936 OD1 ASP A 542 5.539 20.898 −7.736 1.00 58.69 O ATOM 3937 OD2 ASP A 542 3.465 20.232 −7.985 1.00 57.48 O ATOM 3938 C ASP A 542 5.547 21.535 −4.691 1.00 55.72 C ATOM 3939 O ASP A 542 6.113 22.501 −4.168 1.00 55.87 O ATOM 3940 N ILE A 543 6.174 20.403 −5.001 1.00 52.19 N ATOM 3941 CA ILE A 543 7.553 20.137 −4.619 1.00 50.09 C ATOM 3942 CB ILE A 543 7.626 19.597 −3.153 1.00 49.12 C ATOM 3943 CG1 ILE A 543 9.010 19.051 −2.797 1.00 50.55 C ATOM 3944 CD1 ILE A 543 10.032 20.110 −2.450 1.00 53.64 C ATOM 3945 CG2 ILE A 543 6.596 18.511 −2.905 1.00 49.51 C ATOM 3946 C ILE A 543 8.230 19.200 −5.642 1.00 50.83 C ATOM 3947 O ILE A 543 9.093 18.397 −5.282 1.00 51.26 O ATOM 3948 N THR A 544 7.848 19.310 −6.918 1.00 50.74 N ATOM 3949 CA THR A 544 8.437 18.450 −7.958 1.00 51.56 C ATOM 3950 CB THR A 544 7.627 18.407 −9.285 1.00 51.75 C ATOM 3951 OG1 THR A 544 6.262 18.775 −9.060 1.00 54.13 O ATOM 3952 CG2 THR A 544 7.663 17.005 −9.893 1.00 50.16 C ATOM 3953 C THR A 544 9.866 18.909 −8.246 1.00 52.03 C ATOM 3954 O THR A 544 10.072 20.051 −8.659 1.00 52.53 O ATOM 3955 N PRO A 545 10.855 18.016 −8.023 1.00 51.95 N ATOM 3956 CA PRO A 545 12.272 18.357 −8.130 1.00 52.98 C ATOM 3957 CB PRO A 545 12.987 17.097 −7.603 1.00 53.11 C ATOM 3958 CG PRO A 545 11.928 16.253 −6.976 1.00 51.30 C ATOM 3959 CD PRO A 545 10.668 16.593 −7.695 1.00 51.40 C ATOM 3960 C PRO A 545 12.706 18.652 −9.562 1.00 54.25 C ATOM 3961 O PRO A 545 12.408 17.874 −10.469 1.00 54.97 O ATOM 3962 N LEU A 546 13.408 19.772 −9.749 1.00 55.05 N ATOM 3963 CA LEU A 546 13.926 20.170 −11.064 1.00 55.87 C ATOM 3964 CB LEU A 546 13.080 21.305 −11.660 1.00 56.28 C ATOM 3965 CG LEU A 546 11.576 21.086 −11.868 1.00 56.41 C ATOM 3966 CD1 LEU A 546 10.897 22.390 −12.262 1.00 56.07 C ATOM 3967 CD2 LEU A 546 11.302 20.000 −12.901 1.00 56.01 C ATOM 3968 C LEU A 546 15.402 20.590 −10.995 1.00 55.89 C ATOM 3969 O LEU A 546 16.083 20.709 −12.021 1.00 53.56 O ATOM 3970 N GLY A 551 17.976 14.760 −6.588 1.00 52.89 N ATOM 3971 CA GLY A 551 16.779 14.099 −6.074 1.00 55.06 C ATOM 3972 C GLY A 551 15.851 15.026 −5.301 1.00 57.11 C ATOM 3973 O GLY A 551 14.625 14.975 −5.475 1.00 54.09 O ATOM 3974 N LEU A 552 16.442 15.882 −4.459 1.00 58.53 N ATOM 3975 CA LEU A 552 15.692 16.765 −3.543 1.00 58.44 C ATOM 3976 CB LEU A 552 16.372 16.816 −2.166 1.00 56.99 C ATOM 3977 C LEU A 552 15.495 18.186 −4.082 1.00 57.67 C ATOM 3978 O LEU A 552 16.464 18.879 −4.403 1.00 57.74 O ATOM 3979 N SER A 553 14.236 18.614 −4.162 1.00 57.17 N ATOM 3980 CA SER A 553 13.896 19.940 −4.669 1.00 59.39 C ATOM 3981 CB SER A 553 12.482 19.955 −5.246 1.00 61.05 C ATOM 3982 OG SER A 553 12.125 21.255 −5.691 1.00 61.77 O ATOM 3983 C SER A 553 14.009 21.009 −3.593 1.00 60.58 C ATOM 3984 O SER A 553 13.261 20.986 −2.618 1.00 59.55 O ATOM 3985 N PRO A 554 14.941 21.961 −3.776 1.00 63.99 N ATOM 3986 CA PRO A 554 15.076 23.091 −2.861 1.00 65.02 C ATOM 3987 CB PRO A 554 16.558 23.500 −3.018 1.00 65.68 C ATOM 3988 CG PRO A 554 17.165 22.529 −3.995 1.00 65.71 C ATOM 3989 CD PRO A 554 16.024 21.952 −4.771 1.00 64.79 C ATOM 3990 C PRO A 554 14.142 24.250 −3.237 1.00 64.68 C ATOM 3991 O PRO A 554 14.497 25.416 −3.074 1.00 63.80 O ATOM 3992 N LEU A 555 12.955 23.919 −3.737 1.00 65.12 N ATOM 3993 CA LEU A 555 11.979 24.923 −4.169 1.00 67.77 C ATOM 3994 CB LEU A 555 12.199 25.319 −5.644 1.00 68.10 C ATOM 3995 CG LEU A 555 13.061 24.412 −6.540 1.00 68.54 C ATOM 3996 CD1 LEU A 555 12.432 24.184 −7.909 1.00 66.51 C ATOM 3997 CD2 LEU A 555 14.483 24.950 −6.667 1.00 66.91 C ATOM 3998 C LEU A 555 10.551 24.424 −3.936 1.00 68.29 C ATOM 3999 O LEU A 555 10.284 23.224 −4.034 1.00 68.78 O ATOM 4000 N CYS A 556 9.643 25.348 −3.623 1.00 67.63 N ATOM 4001 CA CYS A 556 8.290 24.986 −3.209 1.00 67.14 C ATOM 4002 CB CYS A 556 8.237 24.828 −1.694 1.00 64.14 C ATOM 4003 SG CYS A 556 6.676 24.155 −1.107 1.00 65.33 S ATOM 4004 C CYS A 556 7.229 25.991 −3.661 1.00 70.02 C ATOM 4005 O CYS A 556 7.359 27.193 −3.416 1.00 70.57 O ATOM 4006 N ALA A 557 6.170 25.483 −4.296 1.00 70.62 N ATOM 4007 CA ALA A 557 5.097 26.322 −4.851 1.00 69.38 C ATOM 4008 CB ALA A 557 4.759 25.875 −6.263 1.00 68.10 C ATOM 4009 C ALA A 557 3.839 26.328 −3.980 1.00 68.85 C ATOM 4010 O ALA A 557 3.415 25.287 −3.490 1.00 71.06 O ATOM 4011 N ILE A 558 3.251 27.509 −3.793 1.00 68.74 N ATOM 4012 CA ILE A 558 2.090 27.676 −2.909 1.00 69.65 C ATOM 4013 CB ILE A 558 2.486 28.312 −1.555 1.00 68.97 C ATOM 4014 CG1 ILE A 558 3.970 28.079 −1.230 1.00 71.38 C ATOM 4015 CD1 ILE A 558 4.306 26.715 −0.659 1.00 72.84 C ATOM 4016 CG2 ILE A 558 1.554 27.855 −0.435 1.00 67.12 C ATOM 4017 C ILE A 558 1.031 28.569 −3.559 1.00 72.00 C ATOM 4018 O ILE A 558 1.305 29.230 −4.562 1.00 73.33 O ATOM 4019 N GLY A 559 −0.171 28.584 −2.977 1.00 73.22 N ATOM 4020 CA GLY A 559 −1.277 29.437 −3.438 1.00 72.85 C ATOM 4021 C GLY A 559 −2.266 29.704 −2.317 1.00 72.86 C ATOM 4022 O GLY A 559 −2.735 28.769 −1.669 1.00 72.39 O ATOM 4023 N LEU A 560 −2.588 30.977 −2.084 1.00 72.40 N ATOM 4024 CA LEU A 560 −3.342 31.364 −0.885 1.00 71.82 C ATOM 4025 CB LEU A 560 −2.467 32.219 0.036 1.00 71.37 C ATOM 4026 CG LEU A 560 −0.989 31.868 0.260 1.00 71.10 C ATOM 4027 CD1 LEU A 560 −0.426 32.758 1.354 1.00 72.05 C ATOM 4028 CD2 LEU A 560 −0.767 30.407 0.618 1.00 69.22 C ATOM 4029 C LEU A 560 −4.682 32.070 −1.161 1.00 73.88 C ATOM 4030 O LEU A 560 −4.975 32.436 −2.300 1.00 73.14 O ATOM 4031 N TRP A 561 −5.480 32.252 −0.101 1.00 76.73 N ATOM 4032 CA TRP A 561 −6.828 32.860 −0.179 1.00 74.92 C ATOM 4033 CB TRP A 561 −7.757 32.272 0.888 1.00 74.15 C ATOM 4034 CG TRP A 561 −7.766 30.764 1.009 1.00 73.56 C ATOM 4035 CD1 TRP A 561 −6.718 29.835 1.410 1.00 73.32 C ATOM 4036 NE1 TRP A 561 −7.111 28.619 1.423 1.00 74.18 N ATOM 4037 CE2 TRP A 561 −8.410 28.503 1.063 1.00 75.77 C ATOM 4038 CD3 TRP A 561 −8.903 29.858 0.786 1.00 74.64 C ATOM 4039 CE3 TRP A 561 −10.230 30.027 0.390 1.00 74.57 C ATOM 4040 CZ3 TRP A 561 −11.044 28.888 0.271 1.00 74.51 C ATOM 4041 CH2 TRP A 561 −10.553 27.598 0.543 1.00 74.90 C ATOM 4042 CZ2 TRP A 561 −9.227 27.382 0.941 1.00 76.37 C ATOM 4043 C TRP A 561 −6.802 34.358 −0.006 1.00 71.88 C ATOM 4044 O TRP A 561 −5.957 34.883 0.721 1.00 70.61 O ATOM 4045 N THR A 562 −7.759 35.044 −0.644 1.00 69.63 N ATOM 4046 CA THR A 562 −7.886 36.529 −0.639 1.00 67.90 C ATOM 4047 CB THR A 562 −8.448 37.100 0.692 1.00 66.71 C ATOM 4048 OG1 THR A 562 −7.546 36.816 1.768 1.00 67.43 O ATOM 4049 CG2 THR A 562 −9.831 36.527 1.007 1.00 66.35 C ATOM 4050 C THR A 562 −6.602 37.273 −1.019 1.00 65.62 C ATOM 4051 O THR A 562 −6.644 38.295 −1.705 1.00 61.79 O ATOM 4052 N ASP A 563 −5.473 36.754 −0.545 1.00 66.79 N ATOM 4053 CA ASP A 563 −4.147 37.210 −0.944 1.00 67.72 C ATOM 4054 CB ASP A 563 −3.099 36.773 0.097 1.00 66.65 C ATOM 4055 CG ASP A 563 −3.584 36.941 1.552 1.00 64.29 C ATOM 4056 OD1 ASP A 563 −4.606 37.622 1.791 1.00 62.29 O ATOM 4057 OD2 ASP A 563 −2.932 36.384 2.462 1.00 63.83 O ATOM 4058 C ASP A 563 −3.816 36.634 −2.331 1.00 68.78 C ATOM 4059 O ASP A 563 −2.938 37.144 −3.035 1.00 67.45 O ATOM 4060 N ILE A 564 −4.539 35.564 −2.689 1.00 69.58 N ATOM 4061 CA ILE A 564 −4.574 34.950 −4.040 1.00 68.59 C ATOM 4062 CB ILE A 564 −5.886 35.286 −4.799 1.00 70.07 C ATOM 4063 CG1 ILE A 564 −6.237 36.776 −4.660 1.00 71.96 C ATOM 4064 CD1 ILE A 564 −7.621 37.157 −5.143 1.00 72.98 C ATOM 4065 CG2 ILE A 564 −7.020 34.397 −4.305 1.00 71.58 C ATOM 4066 C ILE A 564 −3.347 35.126 −4.945 1.00 67.83 C ATOM 4067 O ILE A 564 −3.391 35.848 −5.947 1.00 68.49 O ATOM 4068 N SER A 565 −2.261 34.446 −4.587 1.00 67.21 N ATOM 4069 CA SER A 565 −0.987 34.582 −5.294 1.00 65.30 C ATOM 4070 CB SER A 565 −0.120 35.649 −4.614 1.00 64.58 C ATOM 4071 OG SER A 565 1.089 35.865 −5.320 1.00 63.23 O ATOM 4072 C SER A 565 −0.237 33.253 −5.351 1.00 63.25 C ATOM 4073 O SER A 565 −0.498 32.352 −4.555 1.00 63.60 O ATOM 4074 N ALA A 566 0.693 33.144 −6.298 1.00 60.66 N ATOM 4075 CA ALA A 566 1.537 31.961 −6.437 1.00 60.01 C ATOM 4076 CB ALA A 566 1.641 31.565 −7.901 1.00 59.25 C ATOM 4077 C ALA A 566 2.932 32.180 −5.821 1.00 60.58 C ATOM 4078 O ALA A 566 3.876 32.580 −6.508 1.00 60.17 O ATOM 4079 N ARG A 567 3.053 31.907 −4.525 1.00 61.86 N ATOM 4080 CA ARG A 567 4.277 32.218 −3.778 1.00 63.28 C ATOM 4081 CB ARG A 567 3.956 32.580 −2.321 1.00 64.16 C ATOM 4082 CG ARG A 567 2.798 33.552 −2.160 1.00 65.08 C ATOM 4083 CD ARG A 567 3.056 34.586 −1.074 1.00 66.93 C ATOM 4084 NE ARG A 567 2.303 35.811 −1.345 1.00 68.36 N ATOM 4085 CZ ARG A 567 1.241 36.222 −0.657 1.00 66.99 C ATOM 4086 NH1 ARG A 567 0.800 35.524 0.381 1.00 65.85 N ATOM 4087 NH2 ARG A 567 0.625 37.345 −1.003 1.00 66.55 N ATOM 4088 C ARG A 567 5.284 31.076 −3.824 1.00 63.65 C ATOM 4089 O ARG A 567 4.909 29.902 −3.781 1.00 64.53 O ATOM 4090 N ILE A 568 6.563 31.432 −3.914 1.00 62.03 N ATOM 4091 CA ILE A 568 7.645 30.448 −3.965 1.00 61.34 C ATOM 4092 CB ILE A 568 8.556 30.649 −5.205 1.00 60.85 C ATOM 4093 CG1 ILE A 568 7.732 31.011 −6.457 1.00 60.60 C ATOM 4094 CD1 ILE A 568 6.611 30.049 −6.796 1.00 59.13 C ATOM 4095 CG2 ILE A 568 9.461 29.437 −5.436 1.00 59.30 C ATOM 4096 C ILE A 568 8.478 30.552 −2.696 1.00 61.26 C ATOM 4097 O ILE A 568 8.727 31.648 −2.203 1.00 61.50 O ATOM 4098 N LEU A 569 8.905 29.406 −2.173 1.00 62.27 N ATOM 4099 CA LEU A 569 9.634 29.351 −0.908 1.00 63.14 C ATOM 4100 CB LEU A 569 8.707 28.842 0.207 1.00 63.19 C ATOM 4101 CG LEU A 569 7.871 29.793 1.089 1.00 63.28 C ATOM 4102 CD1 LEU A 569 7.854 31.249 0.634 1.00 62.46 C ATOM 4103 CD2 LEU A 569 6.449 29.274 1.256 1.00 62.48 C ATOM 4104 C LEU A 569 10.887 28.475 −1.003 1.00 63.56 C ATOM 4105 O LEU A 569 10.912 27.485 −1.737 1.00 53.72 O ATOM 4106 N LYS A 570 11.926 28.855 −0.261 1.00 65.91 N ATOM 4107 CA LYS A 570 13.156 28.063 −0.176 1.00 67.59 C ATOM 4108 CB LYS A 570 14.320 28.924 0.334 1.00 65.96 C ATOM 4109 C LYS A 570 12.947 26.860 0.743 1.00 67.61 C ATOM 4110 O LYS A 570 12.146 26.921 1.675 1.00 69.11 O ATOM 4111 N LEU A 571 13.653 25.763 0.478 1.00 66.91 N ATOM 4112 CA LEU A 571 13.569 24.603 1.366 1.00 66.40 C ATOM 4113 CB LEU A 571 13.707 23.279 0.608 1.00 65.29 C ATOM 4114 CG LEU A 571 12.369 22.538 0.443 1.00 65.20 C ATOM 4115 CD1 LEU A 571 11.610 22.492 1.762 1.00 63.29 C ATOM 4116 CD2 LEU A 571 11.497 23.166 −0.635 1.00 65.12 C ATOM 4117 C LEU A 571 14.502 24.713 2.575 1.00 67.47 C ATOM 4118 O LEU A 571 15.364 25.598 2.605 1.00 67.13 O ATOM 4119 N PRO A 572 14.383 23.772 3.539 1.00 68.15 N ATOM 4120 CA PRO A 572 14.409 24.070 4.964 1.00 65.27 C ATOM 4121 CB PRO A 572 15.854 23.728 5.340 1.00 64.86 C ATOM 4122 CG PRO A 572 16.199 22.588 4.399 1.00 65.58 C ATOM 4123 CD PRO A 572 15.122 22.518 3.321 1.00 67.68 C ATOM 4124 C PRO A 572 13.997 25.492 5.378 1.00 64.15 C ATOM 4125 O PRO A 572 13.213 25.647 6.314 1.00 62.57 O ATOM 4126 N SER A 573 14.483 26.501 4.655 1.00 64.76 N ATOM 4127 CA SER A 573 14.306 27.919 5.006 1.00 63.80 C ATOM 4128 CB SER A 573 15.165 28.798 4.085 1.00 64.08 C ATOM 4129 OG SER A 573 16.518 28.367 4.071 1.00 62.60 O ATOM 4130 C SER A 573 12.853 28.429 5.020 1.00 63.12 C ATOM 4131 O SER A 573 12.404 28.983 6.022 1.00 62.60 O ATOM 4132 N PHE A 574 12.140 28.251 3.907 1.00 63.78 N ATOM 4133 CA PHE A 574 10.770 28.776 3.727 1.00 65.03 C ATOM 4134 CB PHE A 574 9.859 28.402 4.915 1.00 66.02 C ATOM 4135 CG PHE A 574 9.109 27.106 4.733 1.00 69.32 C ATOM 4136 CD1 PHE A 574 8.121 26.984 3.758 1.00 70.59 C ATOM 4137 CE1 PHE A 574 7.425 25.793 3.592 1.00 69.79 C ATOM 4138 CZ PHE A 574 7.694 24.712 4.415 1.00 69.92 C ATOM 4139 CE2 PHE A 574 8.663 24.822 5.398 1.00 70.47 C ATOM 4140 CD2 PHE A 574 9.366 26.014 5.555 1.00 71.21 C ATOM 4141 C PHE A 574 10.687 30.290 3.438 1.00 64.39 C ATOM 4142 O PHE A 574 9.596 30.866 3.453 1.00 64.83 O ATOM 4143 N GLU A 575 11.825 30.924 3.150 1.00 62.43 N ATOM 4144 CA GLU A 575 11.890 32.391 3.043 1.00 59.93 C ATOM 4145 CB GLU A 575 13.102 32.938 3.818 1.00 56.80 C ATOM 4146 C GLU A 575 11.899 32.912 1.599 1.00 58.61 C ATOM 4147 O GLU A 575 12.966 33.059 0.997 1.00 60.05 O ATOM 4148 N LEU A 576 10.707 33.199 1.066 1.00 55.48 N ATOM 4149 CA LEU A 576 10.519 33.779 −0.285 1.00 52.03 C ATOM 4150 CB LEU A 576 10.104 35.252 −0.194 1.00 49.71 C ATOM 4151 C LEU A 576 11.720 33.624 −1.224 1.00 50.10 C ATOM 4152 O LEU A 576 11.649 32.936 −2.242 1.00 45.83 O ATOM 4153 N HIS A 578 10.973 34.275 −4.322 1.00 59.80 N ATOM 4154 CA HIS A 578 10.271 35.437 −4.872 1.00 62.12 C ATOM 4155 CB HIS A 578 10.523 35.556 −6.385 1.00 60.64 C ATOM 4156 C HIS A 578 8.792 35.382 −4.583 1.00 63.71 C ATOM 4157 O HIS A 578 8.383 34.925 −3.514 1.00 64.70 O ATOM 4158 N LYS A 579 7.988 35.861 −5.535 1.00 65.10 N ATOM 4159 CA LYS A 579 6.527 35.961 −5.409 1.00 65.96 C ATOM 4160 CB LYS A 579 6.151 36.836 −4.196 1.00 64.52 C ATOM 4161 CG LYS A 579 4.657 37.102 −4.006 1.00 63.26 C ATOM 4162 CD LYS A 579 4.288 38.500 −4.491 1.00 63.21 C ATOM 4163 CE LYS A 579 2.784 38.722 −4.483 1.00 62.85 C ATOM 4164 NZ LYS A 579 2.247 38.999 −3.123 1.00 61.93 N ATOM 4165 C LYS A 579 5.970 36.552 −6.711 1.00 68.93 C ATOM 4166 O LYS A 579 6.714 37.160 −7.485 1.00 71.13 O ATOM 4167 N GLU A 580 4.675 36.349 −6.964 1.00 70.88 N ATOM 4168 CA GLU A 580 3.991 36.993 −8.091 1.00 71.52 C ATOM 4169 CB GLU A 580 4.330 36.296 −9.415 1.00 69.11 C ATOM 4170 CG GLU A 580 4.613 37.253 −10.568 1.00 67.57 C ATOM 4171 CD GLU A 580 3.412 38.105 −10.945 1.00 67.36 C ATOM 4172 OE1 GLU A 580 2.321 37.536 −11.180 1.00 67.88 O ATOM 4173 OE2 GLU A 580 3.562 39.345 −11.012 1.00 64.86 O ATOM 4174 C GLU A 580 2.475 37.041 −7.877 1.00 73.94 C ATOM 4175 O GLU A 580 1.814 36.003 −7.849 1.00 74.23 O ATOM 4176 N MET A 581 1.941 38.254 −7.728 1.00 77.32 N ATOM 4177 CA MET A 581 0.508 38.474 −7.479 1.00 77.88 C ATOM 4178 CB MET A 581 0.268 39.905 −6.965 1.00 78.72 C ATOM 4179 CG MET A 581 −1.191 40.279 −6.701 1.00 78.75 C ATOM 4180 SD MET A 581 −1.921 39.553 −5.216 1.00 80.51 S ATOM 4181 CE MET A 581 −1.202 40.567 −3.923 1.00 77.01 C ATOM 4182 C MET A 581 −0.335 38.203 −8.724 1.00 77.76 C ATOM 4183 O MET A 581 0.091 38.470 −9.849 1.00 75.28 O ATOM 4184 N LEU A 582 −1.534 37.671 −8.508 1.00 79.63 N ATOM 4185 CA LEU A 582 −2.457 37.388 −9.599 1.00 81.54 C ATOM 4186 CB LEU A 582 −2.736 35.889 −9.680 1.00 82.08 C ATOM 4187 CG LEU A 582 −3.121 35.359 −11.061 1.00 83.87 C ATOM 4188 CD2 LEU A 582 −4.632 35.351 −11.238 1.00 84.78 C ATOM 4189 CD1 LEU A 582 −2.550 33.964 −11.255 1.00 84.53 C ATOM 4190 C LEU A 582 −3.763 38.169 −9.462 1.00 83.25 C ATOM 4191 O LEU A 582 −4.420 38.470 −10.463 1.00 84.51 O ATOM 4192 N GLY A 583 −4.133 38.490 −8.222 1.00 83.84 N ATOM 4193 CA GLY A 583 −5.353 39.249 −7.942 1.00 80.13 C ATOM 4194 C GLY A 583 −6.616 38.497 −8.318 1.00 77.33 C ATOM 4195 O GLY A 583 −6.620 37.266 −8.380 1.00 76.42 O ATOM 4196 N GLY A 583 −7.684 39.244 −8.586 1.00 74.70 N ATOM 4197 CA GLY A 583 −8.991 38.659 −8.865 1.00 71.05 C ATOM 4198 C GLY A 583 −9.788 38.490 −7.586 1.00 69.71 C ATOM 4199 O GLY A 583 −9.693 39.316 −6.678 1.00 69.93 O ATOM 4200 N GLU A 585 −10.565 37.411 −7.511 1.00 68.75 N ATOM 4201 CA GLU A 585 −11.403 37.123 −6.336 1.00 67.27 C ATOM 4202 CB GLU A 585 −12.764 37.818 −6.465 1.00 64.95 C ATOM 4203 CG GLU A 585 −13.651 37.255 −7.569 1.00 62.95 C ATOM 4204 CD GLU A 585 −14.747 38.211 −7.990 1.00 61.44 C ATOM 4205 OE1 GLU A 585 −15.291 38.924 −7.120 1.00 61.86 O ATOM 4206 OE2 GLU A 585 −15.068 38.245 −9.196 1.00 59.79 O ATOM 4207 C GLU A 585 −11.598 35.620 −6.111 1.00 66.99 C ATOM 4208 O GLU A 585 −12.237 35.207 −5.139 1.00 65.40 O ATOM 4209 N ILE A 586 −11.053 34.815 −7.021 1.00 68.42 N ATOM 4210 CA ILE A 586 −11.181 33.359 −6.961 1.00 69.09 C ATOM 4211 CB ILE A 586 −11.635 32.751 −8.312 1.00 68.97 C ATOM 4212 CG1 ILE A 586 −12.461 33.755 −9.135 1.00 69.17 C ATOM 4213 CD1 ILE A 586 −11.663 34.530 −10.167 1.00 67.72 C ATOM 4214 CG2 ILE A 586 −12.436 31.476 −8.078 1.00 69.04 C ATOM 4215 C ILE A 586 −9.859 32.722 −6.533 1.00 69.94 C ATOM 4216 O ILE A 586 −8.783 33.179 −6.923 1.00 68.83 O ATOM 4217 N ILE A 587 −9.953 31.670 −5.724 1.00 70.34 N ATOM 4218 CA ILE A 587 −8.777 30.968 −5.208 1.00 70.28 C ATOM 4219 CB ILE A 587 −9.073 30.266 −3.861 1.00 69.93 C ATOM 4220 CG1 ILE A 587 −10.497 29.681 −3.828 1.00 69.57 C ATOM 4221 CD1 ILE A 587 −10.598 28.222 −4.237 1.00 68.74 C ATOM 4222 CG2 ILE A 587 −8.879 31.238 −2.712 1.00 69.02 C ATOM 4223 C ILE A 587 −8.203 29.961 −6.213 1.00 72.59 C ATOM 4224 O ILE A 587 −8.962 29.316 −6.948 1.00 73.40 O ATOM 4225 N PRO A 588 −6.857 29.833 −6.260 1.00 72.77 N ATOM 4226 CA PRO A 588 −6.227 28.832 −7.126 1.00 70.85 C ATOM 4227 CB PRO A 588 −4.744 29.218 −7.095 1.00 69.48 C ATOM 4228 CG PRO A 588 −4.564 29.970 −5.823 1.00 70.26 C ATOM 4229 CD PRO A 588 −5.860 30.689 −5.586 1.00 71.84 C ATOM 4230 C PRO A 588 −6.425 27.419 −6.587 1.00 70.35 C ATOM 4231 O PRO A 588 −6.349 27.203 −5.373 1.00 69.44 O ATOM 4232 N ARG A 589 −6.690 26.473 −7.486 1.00 69.73 N ATOM 4233 CA ARG A 589 −6.936 25.083 −7.097 1.00 68.14 C ATOM 4234 CB ARG A 589 −8.124 24.502 −7.874 1.00 66.40 C ATOM 4235 C ARG A 589 −5.695 24.201 −7.267 1.00 66.17 C ATOM 4236 O ARG A 589 −5.389 23.386 −6.390 1.00 67.29 O ATOM 4237 N SER A 590 −4.987 24.377 −8.387 1.00 61.80 N ATOM 4238 CA SER A 590 −3.818 23.557 −8.723 1.00 57.55 C ATOM 4239 CB SER A 590 −4.105 22.696 −9.952 1.00 55.40 C ATOM 4240 C SER A 590 −2.568 24.390 −8.976 1.00 56.70 C ATOM 4241 O SER A 590 −2.645 25.497 −9.515 1.00 56.61 O ATOM 4242 N ILE A 591 −1.418 23.840 −8.590 1.00 55.56 N ATOM 4243 CA ILE A 591 −0.118 24.462 −8.854 1.00 54.61 C ATOM 4244 CB ILE A 591 0.307 25.421 −7.711 1.00 54.49 C ATOM 4245 CG1 ILE A 591 1.309 26.465 −8.219 1.00 55.18 C ATOM 4246 CD1 ILE A 591 1.179 27.821 −7.552 1.00 55.59 C ATOM 4247 CG2 ILE A 591 0.842 24.655 −6.506 1.00 53.91 C ATOM 4248 C ILE A 591 0.955 23.400 −9.128 1.00 54.72 C ATOM 4249 O ILE A 591 0.957 22.335 −8.507 1.00 53.04 O ATOM 4250 N LEU A 592 1.854 23.692 −10.068 1.00 56.48 N ATOM 4251 CA LEU A 592 2.846 22.718 −10.521 1.00 55.47 C ATOM 4252 CB LEU A 592 2.233 21.807 −11.592 1.00 54.38 C ATOM 4253 CG LEU A 592 3.038 20.616 −12.118 1.00 54.72 C ATOM 4254 CD1 LEU A 592 3.288 19.572 −11.038 1.00 53.46 C ATOM 4255 CD2 LEU A 592 2.322 19.994 −13.307 1.00 55.60 C ATOM 4256 C LEU A 592 4.106 23.378 −11.063 1.00 56.68 C ATOM 4257 O LEU A 592 4.029 24.314 −11.854 1.00 56.99 O ATOM 4258 N MET A 593 5.261 22.885 −10.620 1.00 61.05 N ATOM 4259 CA MET A 593 6.560 23.240 −11.206 1.00 63.54 C ATOM 4260 CB MET A 593 7.626 23.386 −10.117 1.00 61.61 C ATOM 4261 CG MET A 593 7.343 24.455 −9.078 1.00 60.16 C ATOM 4262 SD MET A 593 8.647 24.561 −7.837 1.00 59.21 S ATOM 4263 CE MET A 593 8.576 22.925 −7.107 1.00 59.55 C ATOM 4264 C MET A 593 6.980 22.132 −12.171 1.00 67.94 C ATOM 4265 O MET A 593 7.040 20.960 −11.782 1.00 71.78 O ATOM 4266 N THR A 594 7.282 22.497 −13.418 1.00 69.11 N ATOM 4267 CA THR A 594 7.512 21.503 −14.478 1.00 67.56 C ATOM 4268 CB THR A 594 6.174 21.066 −15.105 1.00 65.01 C ATOM 4269 OG1 THR A 594 6.413 20.080 −16.112 1.00 67.70 O ATOM 4270 CG2 THR A 594 5.451 22.255 −15.716 1.00 64.19 C ATOM 4271 C THR A 594 8.502 21.970 −15.569 1.00 68.59 C ATOM 4272 O THR A 594 8.767 23.167 −15.692 1.00 70.03 O ATOM 4273 N THR A 595 9.031 21.026 −16.357 1.00 68.56 N ATOM 4274 CA THR A 595 10.099 21.324 −17.336 1.00 68.61 C ATOM 4275 CB THR A 595 11.497 20.885 −16.811 1.00 69.03 C ATOM 4276 OG1 THR A 595 12.501 21.207 −17.779 1.00 71.98 O ATOM 4277 CG2 THR A 595 11.549 19.382 −16.514 1.00 69.92 C ATOM 4278 C THR A 595 9.867 20.806 −18.778 1.00 69.19 C ATOM 4279 O THR A 595 9.798 19.597 −19.013 1.00 71.35 O ATOM 4280 N PHE A 596 9.767 21.729 −19.735 1.00 69.13 N ATOM 4281 CA PHE A 596 9.600 21.371 −21.150 1.00 70.62 C ATOM 4282 CB PHE A 596 8.410 22.108 −21.762 1.00 70.98 C ATOM 4283 CG PHE A 596 7.097 21.813 −21.096 1.00 70.07 C ATOM 4284 CD1 PHE A 596 6.578 20.522 −21.081 1.00 69.26 C ATOM 4285 CE1 PHE A 596 5.359 20.255 −20.476 1.00 68.82 C ATOM 4286 CZ PHE A 596 4.637 21.284 −19.889 1.00 68.86 C ATOM 4287 CE2 PHE A 596 5.138 22.577 −19.908 1.00 69.10 C ATOM 4288 CD2 PHE A 596 6.358 22.838 −20.513 1.00 69.51 C ATOM 4289 C PHE A 596 10.850 21.677 −21.973 1.00 73.15 C ATOM 4290 O PHE A 596 11.480 22.722 −21.785 1.00 75.41 O ATOM 4291 N GLU A 597 11.168 20.783 −22.915 1.00 75.03 N ATOM 4292 CA GLU A 597 12.426 20.822 −23.692 1.00 77.32 C ATOM 4293 CB GLU A 597 12.493 22.050 −24.616 1.00 74.76 C ATOM 4294 C GLU A 597 13.646 20.739 −22.757 1.00 78.47 C ATOM 4295 O GLU A 597 14.200 19.655 −22.543 1.00 79.84 O ATOM 4296 N SER A 598 14.053 21.883 −22.210 1.00 75.61 N ATOM 4297 CA SER A 598 14.938 21.925 −21.043 1.00 71.35 C ATOM 4298 CB SER A 598 16.406 21.779 −21.446 1.00 69.45 C ATOM 4299 OG SER A 598 17.159 21.231 −20.378 1.00 66.21 O ATOM 4300 C SER A 598 14.709 23.217 −20.256 1.00 69.68 C ATOM 4301 O SER A 598 15.417 23.510 −19.289 1.00 68.95 O ATOM 4302 N SER A 599 13.710 23.980 −20.690 1.00 68.29 N ATOM 4303 CA SER A 599 13.282 25.186 −20.001 1.00 66.34 C ATOM 4304 CB SER A 599 12.608 26.138 −20.990 1.00 65.17 C ATOM 4305 OG SER A 599 12.289 27.367 −20.370 1.00 64.04 O ATOM 4306 C SER A 599 12.324 24.819 −18.868 1.00 65.93 C ATOM 4307 O SER A 599 11.638 23.801 −18.932 1.00 65.40 O ATOM 4308 N HIS A 600 12.285 25.654 −17.833 1.00 67.95 N ATOM 4309 CA HIS A 600 11.471 25.392 −16.647 1.00 66.67 C ATOM 4310 CB HIS A 600 12.334 25.424 −15.386 1.00 67.33 C ATOM 4311 CG HIS A 600 13.474 24.425 −15.389 1.00 69.16 C ATOM 4312 ND1 HIS A 600 13.398 23.236 −14.763 1.00 71.11 N ATOM 4313 CE1 HIS A 600 14.558 22.567 −14.926 1.00 71.28 C ATOM 4314 NE2 HIS A 600 15.382 23.334 −15.657 1.00 69.63 N ATOM 4315 CD2 HIS A 600 14.749 24.489 −15.957 1.00 69.81 C ATOM 4316 C HIS A 600 10.351 35.388 −16.517 1.00 66.58 C ATOM 4317 O HIS A 600 10.526 27.578 −16.804 1.00 66.18 O ATOM 4318 N TYR A 601 9.188 25.908 −16.075 1.00 65.05 N ATOM 4319 CA TYR A 601 8.031 26.772 −15.822 1.00 63.98 C ATOM 4320 CB TYR A 601 6.997 26.656 −16.953 1.00 63.15 C ATOM 4321 CG TYR A 601 7.540 26.773 −18.365 1.00 63.90 C ATOM 4322 CD1 TYR A 601 8.088 25.667 −19.014 1.00 63.91 C ATOM 4323 CE1 TYR A 601 8.567 25.763 −20.312 1.00 65.42 C ATOM 4324 CZ TYR A 601 8.493 26.974 −20.987 1.00 64.31 C ATOM 4325 OH TYR A 601 8.974 27.053 −22.273 1.00 63.83 O ATOM 4326 CE2 TYR A 601 7.943 25.087 −20.371 1.00 63.19 C ATOM 4327 CD2 TYR A 601 7.467 27.981 −19.069 1.00 64.37 C ATOM 4328 C TYR A 601 7.345 26.473 −14.476 1.00 63.36 C ATOM 4329 O TYR A 601 7.620 25.461 −13.822 1.00 61.88 O ATOM 4330 N LEU A 602 6.461 27.380 −14.069 1.00 62.23 N ATOM 4331 CA LEU A 602 5.516 27.129 −12.988 1.00 59.95 C ATOM 4332 CB LEU A 602 5.765 28.074 −11.810 1.00 58.82 C ATOM 4333 CG LEU A 602 4.883 27.909 −10.565 1.00 57.23 C ATOM 4334 CD1 LEU A 602 5.740 27.917 −9.314 1.00 57.18 C ATOM 4335 CD2 LEU A 602 3.794 28.969 −10.484 1.00 54.84 C ATOM 4336 C LEU A 602 4.108 27.318 −13.537 1.00 60.34 C ATOM 4337 O LEU A 602 3.853 28.243 −14.315 1.00 61.54 O ATOM 4338 N LEU A 603 3.202 26.433 −13.138 1.00 58.73 N ATOM 4339 CA LEU A 603 1.838 26.436 −13.648 1.00 57.98 C ATOM 4340 CB LEU A 603 1.536 25.113 −14.357 1.00 54.86 C ATOM 4341 CG LEU A 603 1.766 24.922 −15.859 1.00 53.01 C ATOM 4342 CD1 LEU A 603 2.950 25.713 −16.395 1.00 53.86 C ATOM 4343 CD2 LEU A 603 1.927 23.441 −16.167 1.00 52.30 C ATOM 4344 C LEU A 603 0.854 26.638 −12.513 1.00 60.02 C ATOM 4345 O LEU A 603 0.914 25.941 −11.499 1.00 61.24 O ATOM 4346 N CYS A 604 −0.054 27.593 −12.679 1.00 60.60 N ATOM 4347 CA CYS A 604 −1.113 27.771 −11.704 1.00 61.22 C ATOM 4348 CB CYS A 604 −0.869 28.995 −10.834 1.00 61.19 C ATOM 4349 SG CYS A 604 −1.884 28.959 −9.344 1.00 63.18 S ATOM 4350 C CYS A 604 −2.471 27.859 −12.364 1.00 61.65 C ATOM 4351 O CYS A 604 −2.698 28.705 −13.232 1.00 62.46 O ATOM 4352 N ALA A 605 −3.368 26.973 −11.936 1.00 61.34 N ATOM 4353 CA ALA A 605 −4.711 26.882 −12.490 1.00 61.95 C ATOM 4354 CB ALA A 605 −5.020 25.450 −12.882 1.00 60.03 C ATOM 4355 C ALA A 605 −5.752 27.411 −11.508 1.00 63.59 C ATOM 4356 O ALA A 605 −5.702 27.111 −10.310 1.00 63.42 O ATOM 4357 N LEU A 606 −6.699 28.187 −12.031 1.00 65.82 N ATOM 4358 CA LEU A 606 −7.676 28.899 −11.209 1.00 66.77 C ATOM 4359 CB LEU A 606 −7.903 30.308 −11.761 1.00 66.19 C ATOM 4360 CG LEU A 606 −7.113 31.412 −11.051 1.00 67.42 C ATOM 4361 CD1 LEU A 606 −6.693 32.515 −12.014 1.00 66.37 C ATOM 4362 CD2 LEU A 606 −7.915 31.975 −9.885 1.00 66.45 C ATOM 4363 C LEU A 606 −9.010 28.177 −11.028 1.00 68.51 C ATOM 4364 O LEU A 606 −9.400 27.341 −11.847 1.00 68.09 O ATOM 4365 N GLY A 607 −9.701 28.519 −9.939 1.00 71.96 N ATOM 4366 CA GLY A 607 −11.006 27.947 −9.608 1.00 73.26 C ATOM 4367 C GLY A 607 −12.146 28.444 −10.482 1.00 74.18 C ATOM 4368 O GLY A 607 −13.277 27.959 −10.367 1.00 73.69 O ATOM 4369 N ASP A 608 −11.853 29.419 −11.347 1.00 74.26 N ATOM 4370 CA ASP A 608 −12.821 29.900 −12.342 1.00 71.92 C ATOM 4371 CB ASP A 608 −12.807 31.442 −12.460 1.00 72.61 C ATOM 4372 CG ASP A 608 −11.639 31.978 −13.296 1.00 72.81 C ATOM 4373 OD1 ASP A 608 −11.007 31.205 −14.050 1.00 71.22 O ATOM 4374 OD2 ASP A 608 −11.363 33.196 −13.201 1.00 72.14 O ATOM 4375 C ASP A 608 −12.599 29.238 −13.697 1.00 66.42 C ATOM 4376 O ASP A 608 −13.448 29.322 −14.580 1.00 64.21 O ATOM 4377 N GLY A 609 −11.444 28.596 −13.846 1.00 63.74 N ATOM 4378 CA GLY A 609 −11.096 27.891 −15.071 1.00 63.96 C ATOM 4379 C GLY A 609 −9.889 28.460 −15.786 1.00 62.89 C ATOM 4380 O GLY A 609 −9.501 27.979 −16.853 1.00 62.47 O ATOM 4381 N ALA A 610 −9.289 29.489 −15.200 1.00 63.41 N ATOM 4382 CA ALA A 610 −8.144 30.137 −15.816 1.00 64.55 C ATOM 4383 CB ALA A 610 −7.984 31.556 −15.289 1.00 65.67 C ATOM 4384 C ALA A 610 −6.877 29.332 −15.590 1.00 63.40 C ATOM 4385 O ALA A 610 −6.809 28.494 −14.697 1.00 61.36 O ATOM 4386 N LEU A 611 −5.881 29.583 −16.427 1.00 66.48 N ATOM 4387 CA LEU A 611 −4.560 29.007 −16.250 1.00 70.18 C ATOM 4388 CB LEU A 611 −4.383 27.757 −17.133 1.00 70.35 C ATOM 4389 CG LEU A 611 −3.078 26.932 −17.178 1.00 71.17 C ATOM 4390 CD1 LEU A 611 −2.067 27.530 −18.147 1.00 71.17 C ATOM 4391 CD2 LEU A 611 −2.440 26.701 −15.810 1.00 70.73 C ATOM 4392 C LEU A 611 −3.506 30.065 −16.555 1.00 71.48 C ATOM 4393 O LEU A 611 −3.559 30.739 −17.591 1.00 69.86 O ATOM 4394 N PHE A 612 −2.596 30.216 −15.625 1.00 73.95 N ATOM 4395 CA PHE A 612 −1.438 31.110 −15.794 1.00 77.88 C ATOM 4396 CB PHE A 612 −1.355 32.094 −14.624 1.00 83.00 C ATOM 4397 CG PHE A 612 −2.279 33.273 −14.755 1.00 88.89 C ATOM 4398 CD2 PHE A 612 −1.789 34.513 −15.154 1.00 90.61 C ATOM 4399 CE2 PHE A 612 −2.638 35.605 −15.279 1.00 92.18 C ATOM 4400 CZ PHE A 612 −3.991 35.466 −15.008 1.00 92.00 C ATOM 4401 CE1 PHE A 612 −4.493 34.235 −14.613 1.00 93.06 C ATOM 4402 CD1 PHE A 612 −3.640 33.146 −14.487 1.00 91.87 C ATOM 4403 C PHE A 612 −0.165 30.289 −15.877 1.00 77.24 C ATOM 4404 O PHE A 612 −0.001 29.314 −15.138 1.00 79.37 O ATOM 4405 N TYR A 613 0.725 30.668 −16.790 1.00 74.62 N ATOM 4406 CA TYR A 613 2.035 30.027 −16.887 1.00 73.06 C ATOM 4407 CB TYR A 613 2.121 29.060 −18.082 1.00 71.88 C ATOM 4408 CG TYR A 613 1.778 29.630 −19.452 1.00 72.39 C ATOM 4409 CD1 TYR A 613 0.472 30.018 −19.772 1.00 72.34 C ATOM 4410 CE1 TYR A 613 0.157 30.517 −21.031 1.00 71.61 C ATOM 4411 CZ TYR A 613 1.150 30.615 −21.996 1.00 71.37 C ATOM 4412 OH TYR A 613 0.847 31.104 −23.245 1.00 68.39 O ATOM 4413 CE2 TYR A 613 2.445 30.221 −21.711 1.00 72.78 C ATOM 4414 CD2 TYR A 613 2.752 29.724 −20.449 1.00 73.26 C ATOM 4415 C TYR A 613 3.184 31.035 −16.871 1.00 72.63 C ATOM 4416 O TYR A 613 3.345 31.837 −17.794 1.00 72.78 O ATOM 4417 N PHE A 614 3.959 30.993 −15.791 1.00 70.95 N ATOM 4418 CA PHE A 614 5.091 31.885 −15.602 1.00 69.51 C ATOM 4419 CB PHE A 614 5.138 32.385 −14.153 1.00 69.52 C ATOM 4420 CG PHE A 614 3.968 33.251 −13.764 1.00 71.10 C ATOM 4421 CD1 PHE A 614 3.954 34.613 −14.073 1.00 70.94 C ATOM 4422 CE1 PHE A 614 2.878 35.416 −13.714 1.00 69.57 C ATOM 4423 CZ PHE A 614 1.804 34.864 −13.031 1.00 69.87 C ATOM 4424 CE2 PHE A 614 1.806 33.511 −12.711 1.00 70.23 C ATOM 4425 CD2 PHE A 614 2.884 32.712 −13.074 1.00 70.37 C ATOM 4426 C PHE A 614 6.399 31.180 −15.945 1.00 70.03 C ATOM 4427 O PHE A 614 6.508 29.958 −15.813 1.00 69.62 O ATOM 4428 N GLY A 615 7.383 31.954 −16.400 1.00 69.84 N ATOM 4429 CA GLY A 615 8.754 31.466 −16.538 1.00 70.06 C ATOM 4430 C GLY A 615 9.368 31.324 −15.158 1.00 71.25 C ATOM 4431 O GLY A 615 8.904 31.946 −14.203 1.00 72.04 O ATOM 4432 N LEU A 616 10.410 30.508 −15.042 1.00 71.99 N ATOM 4433 CA LEU A 616 10.981 30.215 −13.729 1.00 72.48 C ATOM 4434 CB LEU A 616 10.649 28.776 −13.327 1.00 70.89 C ATOM 4435 CG LEU A 616 10.504 28.479 −11.831 1.00 70.86 C ATOM 4436 CD1 LEU A 616 9.820 29.620 −11.087 1.00 70.64 C ATOM 4437 CD2 LEU A 616 9.751 27.174 −11.630 1.00 70.21 C ATOM 4438 C LEU A 616 12.488 30.469 −13.624 1.00 75.56 C ATOM 4439 O LEU A 616 13.181 30.618 −14.636 1.00 78.52 O ATOM 4440 N ASN A 617 12.978 30.548 −12.389 1.00 75.23 N ATOM 4441 CA ASN A 617 14.410 30.602 −12.125 1.00 74.47 C ATOM 4442 CB ASN A 617 14.818 31.975 −11.594 1.00 71.77 C ATOM 4443 C ASN A 617 14.808 29.492 −11.158 1.00 74.32 C ATOM 4444 O ASN A 617 14.541 29.576 −9.956 1.00 72.37 O ATOM 4445 N ILE A 618 15.428 28.449 −11.710 1.00 75.26 N ATOM 4446 CA ILE A 618 15.826 27.237 −10.969 1.00 73.42 C ATOM 4447 CB ILE A 618 16.638 26.258 −11.860 1.00 71.23 C ATOM 4448 CG1 ILE A 618 17.329 26.992 −13.030 1.00 69.60 C ATOM 4449 CD1 ILE A 618 18.632 27.691 −12.686 1.00 64.62 C ATOM 4450 CG2 ILE A 618 15.736 25.153 −12.384 1.00 69.29 C ATOM 4451 C ILE A 618 16.605 27.489 −9.672 1.00 74.01 C ATOM 4452 O ILE A 618 16.380 26.807 −8.668 1.00 71.27 O ATOM 4453 N GLU A 619 17.516 28.464 −9.710 1.00 72.73 N ATOM 4454 CA GLU A 619 18.335 28.823 −8.554 1.00 69.74 C ATOM 4455 CB GLU A 619 19.809 28.932 −8.959 1.00 68.90 C ATOM 4456 C GLU A 619 17.861 30.127 −7.908 1.00 68.32 C ATOM 4457 O THR A 619 17.920 30.276 −6.686 1.00 66.49 O ATOM 4458 N THR A 620 17.388 31.062 −8.733 1.00 67.72 N ATOM 4459 CA THR A 620 16.944 32.377 −8.259 1.00 64.65 C ATOM 4460 CB THR A 620 16.940 33.422 −9.393 1.00 62.51 C ATOM 4461 C THR A 620 15.567 32.326 −7.594 1.00 63.53 C ATOM 4462 O THR A 620 15.444 32.625 −6.407 1.00 62.95 O ATOM 4463 N GLY A 621 14.540 31.956 −8.363 1.00 62.70 N ATOM 4464 CA GLY A 621 13.178 31.811 −7.838 1.00 60.61 C ATOM 4465 C GLY A 621 12.129 32.797 −8.343 1.00 60.22 C ATOM 4466 O GLY A 621 10.956 32.697 −7.977 1.00 58.25 O ATOM 4467 N LEU A 623 12.543 33.749 −9.179 1.00 61.52 N ATOM 4468 CA LEU A 623 11.630 34.776 −9.695 1.00 60.19 C ATOM 4469 CB LEU A 623 12.400 36.054 −10.057 1.00 60.10 C ATOM 4470 C LEU A 623 10.828 34.259 −10.892 1.00 58.73 C ATOM 4471 O LEU A 623 11.283 33.365 −11.608 1.00 59.23 O ATOM 4472 N LEU A 623 9.636 34.819 −11.097 1.00 57.65 N ATOM 4473 CA LEU A 623 8.730 34.355 −12.160 1.00 58.00 C ATOM 4474 CB LEU A 623 7.504 33.646 −11.563 1.00 56.81 C ATOM 4475 C LEU A 623 8.298 35.467 −13.129 1.00 56.78 C ATOM 4476 O LEU A 623 8.132 36.621 −12.733 1.00 56.28 O ATOM 4477 N SER A 624 8.100 35.098 −14.394 1.00 56.30 N ATOM 4478 CA SER A 624 7.840 36.067 −15.460 1.00 55.15 C ATOM 4479 CB SER A 624 9.143 36.395 −16.184 1.00 54.13 C ATOM 4480 OG SER A 624 9.729 35.214 −16.702 1.00 52.98 O ATOM 4481 C SER A 624 6.800 35.592 −16.483 1.00 55.31 C ATOM 4482 O SER A 624 6.771 34.415 −16.857 1.00 55.35 O ATOM 4483 N ASP A 625 5.967 36.533 −16.937 1.00 54.14 N ATOM 4484 CA ASP A 625 4.999 36.327 −18.033 1.00 50.79 C ATOM 4485 CB ASP A 625 5.651 35.624 −19.229 1.00 51.15 C ATOM 4486 CG ASP A 625 6.993 36.248 −19.613 1.00 53.05 C ATOM 4487 OD1 ASP A 625 7.120 37.496 −19.577 1.00 51.81 O ATOM 4488 OD2 ASP A 625 7.926 35.483 −19.937 1.00 53.80 O ATOM 4489 C ASP A 625 3.723 35.619 −17.604 1.00 47.71 C ATOM 4490 O ASP A 625 2.731 36.270 −17.274 1.00 44.04 O ATOM 4491 N LYS A 627 1.443 35.803 −20.117 1.00 60.53 N ATOM 4492 CA LYS A 627 1.209 34.412 −20.495 1.00 63.89 C ATOM 4493 CB LYS A 627 2.501 33.599 −20.354 1.00 62.91 C ATOM 4494 C LYS A 627 0.048 33.769 −19.702 1.00 65.61 C ATOM 4495 O LYS A 627 0.235 33.256 −18.589 1.00 65.15 O ATOM 4496 N LYS A 628 −1.145 33.804 −20.296 1.00 66.68 N ATOM 4497 CA LYS A 628 −2.379 33.318 −19.660 1.00 66.88 C ATOM 4498 CB LYS A 628 −3.083 34.474 −18.928 1.00 64.93 C ATOM 4499 CG LYS A 628 −4.567 34.656 −19.230 1.00 63.02 C ATOM 4500 CD LYS A 628 −5.441 34.195 −18.080 1.00 62.61 C ATOM 4501 CE LYS A 628 −6.744 34.976 −18.052 1.00 61.98 C ATOM 4502 NZ LYS A 628 −7.276 35.137 −16.670 1.00 61.13 N ATOM 4503 C LYS A 628 −3.310 32.668 −20.687 1.00 68.01 C ATOM 4504 O LYS A 628 −3.241 32.981 −21.882 1.00 67.62 O ATOM 4505 N VAL A 629 −4.170 31.764 −20.213 1.00 67.42 N ATOM 4506 CA VAL A 629 −5.157 31.088 −21.065 1.00 67.85 C ATOM 4507 CB VAL A 629 −4.495 30.004 −21.968 1.00 68.50 C ATOM 4508 CG1 VAL A 629 −3.602 29.071 −21.159 1.00 68.26 C ATOM 4509 CG2 VAL A 629 −5.537 29.224 −22.764 1.00 69.93 C ATOM 4510 C VAL A 629 −6.302 30.500 −20.230 1.00 67.66 C ATOM 4511 O VAL A 629 −6.070 29.974 −19.140 1.00 70.23 O ATOM 4512 N THR A 630 −7.534 30.613 −20.731 1.00 65.48 N ATOM 4513 CA THR A 630 −8.694 29.978 −20.085 1.00 64.98 C ATOM 4514 CB THR A 630 −9.927 30.911 −20.018 1.00 64.27 C ATOM 4515 OG1 THR A 630 −10.504 31.052 −21.320 1.00 64.80 O ATOM 4516 CG2 THR A 630 −9.550 32.289 −19.470 1.00 62.75 C ATOM 4517 C THR A 630 −9.061 28.656 −20.779 1.00 63.77 C ATOM 4518 O THR A 630 −8.891 28.511 −21.989 1.00 60.51 O ATOM 4519 N LEU A 631 −9.562 27.698 −20.000 1.00 64.92 N ATOM 4520 CA LEU A 631 −9.756 26.327 −20.482 1.00 65.71 C ATOM 4521 CB LEU A 631 −8.714 25.396 −19.850 1.00 62.96 C ATOM 4522 CG LEU A 631 −7.304 25.942 −19.583 1.00 60.76 C ATOM 4523 CD1 LEU A 631 −6.571 25.057 −18.590 1.00 60.24 C ATOM 4524 CD2 LEU A 631 −6.500 26.097 −20.867 1.00 59.81 C ATOM 4525 C LEU A 631 −11.168 25.778 −20.224 1.00 69.30 C ATOM 4526 O LEU A 631 −11.658 24.930 −20.973 1.00 70.69 O ATOM 4527 N GLY A 632 −11.809 26.252 −19.159 1.00 69.62 O ATOM 4528 CA GLY A 632 −13.153 25.806 −18.803 1.00 74.19 C ATOM 4529 C GLY A 632 −13.480 26.109 −17.356 1.00 77.98 C ATOM 4530 O GLY A 632 −12.683 25.817 −16.464 1.00 79.57 O ATOM 4531 N THR A 633 −14.675 26.658 −17.131 1.00 80.62 N ATOM 4532 CA THR A 633 −15.079 27.228 −15.830 1.00 82.84 C ATOM 4533 CB THR A 633 −16.518 27.792 −15.864 1.00 83.85 C ATOM 4534 OG1 THR A 633 −17.425 26.772 −16.301 1.00 84.83 O ATOM 4535 CG2 THR A 633 −16.611 29.015 −16.789 1.00 81.85 C ATOM 4536 C THR A 633 −14.939 26.318 −14.606 1.00 84.24 C ATOM 4537 O THR A 633 −14.722 26.808 −13.492 1.00 84.69 O ATOM 4538 N GLN A 634 −15.085 25.007 −14.806 1.00 83.04 N ATOM 4539 CA GLN A 634 −14.820 24.035 −13.745 1.00 80.21 C ATOM 4540 CB GLN A 634 −15.358 22.649 −14.120 1.00 76.41 C ATOM 4541 C GLN A 634 −13.309 23.987 −13.447 1.00 78.80 C ATOM 4542 O GLN A 634 −12.498 23.837 −14.371 1.00 77.07 O ATOM 4543 N PRO A 635 −12.931 24.146 −12.157 1.00 76.37 N ATOM 4544 CA PRO A 635 −11.540 24.178 −11.684 1.00 74.01 C ATOM 4545 CB PRO A 635 −11.686 23.955 −10.177 1.00 76.16 C ATOM 4546 CG PRO A 635 −12.994 24.584 −9.847 1.00 76.06 C ATOM 4547 CD PRO A 635 −13.882 24.388 −11.052 1.00 76.79 C ATOM 4548 C PRO A 635 −10.638 23.100 −12.298 1.00 70.56 C ATOM 4549 O PRO A 635 −11.057 21.952 −12.469 1.00 71.18 O ATOM 4550 N THR A 636 −9.403 23.484 −12.602 1.00 65.20 N ATOM 4551 CA THR A 636 −8.468 22.640 −13.339 1.00 61.67 C ATOM 4552 CB THR A 636 −7.629 23.488 −14.318 1.00 62.18 C ATOM 4553 OG1 THR A 636 −8.396 24.619 −14.758 1.00 63.11 O ATOM 4554 CG2 THR A 636 −7.185 22.667 −15.524 1.00 59.51 C ATOM 4555 C THR A 636 −7.529 21.891 −12.391 1.00 59.20 C ATOM 4556 O THR A 636 −7.184 22.404 −11.328 1.00 59.98 O ATOM 4557 N VAL A 637 −7.128 20.679 −12.786 1.00 56.20 N ATOM 4558 CA VAL A 637 −6.172 19.849 −12.024 1.00 53.28 C ATOM 4559 CB VAL A 637 −6.874 18.620 −11.381 1.00 50.32 C ATOM 4560 CG1 VAL A 637 −5.881 17.740 −10.634 1.00 48.48 C ATOM 4561 CG2 VAL A 637 −7.988 19.066 −10.446 1.00 49.37 C ATOM 4562 C VAL A 637 −5.018 19.399 −12.945 1.00 52.78 C ATOM 4563 O VAL A 637 −5.255 18.989 −14.085 1.00 53.36 O ATOM 4564 N LEU A 638 −3.779 19.475 −12.456 1.00 49.78 N ATOM 4565 CA LEU A 638 −2.610 19.184 −13.294 1.00 48.60 C ATOM 4566 CB LEU A 638 −1.669 20.386 −13.345 1.00 49.05 C ATOM 4567 CG LEU A 638 −2.284 21.783 −13.404 1.00 49.76 C ATOM 4568 CD1 LEU A 638 −1.267 22.802 −12.914 1.00 49.58 C ATOM 4569 CD2 LEU A 638 −2.793 22.124 −14.801 1.00 48.13 C ATOM 4570 C LEU A 638 −1.823 17.968 −12.833 1.00 48.45 C ATOM 4571 O LEU A 638 −1.516 17.831 −11.655 1.00 50.58 O ATOM 4572 N ARG A 639 −1.491 17.093 −13.778 1.00 49.22 N ATOM 4573 CA ARG A 639 −0.609 15.956 −13.516 1.00 47.90 C ATOM 4574 CB ARG A 639 −1.389 14.627 −13.460 1.00 50.04 C ATOM 4575 CG ARG A 639 −2.135 14.375 −12.152 1.00 55.11 C ATOM 4576 CD ARG A 639 −1.212 13.989 −11.003 1.00 56.65 C ATOM 4577 NE ARG A 639 −0.810 12.577 −11.032 1.00 61.56 N ATOM 4578 CZ ARG A 639 −1.285 11.630 −10.213 1.00 62.96 C ATOM 4579 NH1 ARG A 639 −2.195 11.918 −9.290 1.00 63.23 N ATOM 4580 NH2 ARG A 639 −0.844 10.385 −10.310 1.00 61.04 N ATOM 4581 C ARG A 639 0.495 15.871 −14.557 1.00 44.29 C ATOM 4582 O ARG A 639 0.343 16.331 −15.687 1.00 41.78 O ATOM 4583 N THR A 640 1.609 15.277 −14.157 1.00 42.30 N ATOM 4584 CA THR A 640 2.721 15.047 −15.048 1.00 41.95 C ATOM 4585 CB THR A 640 4.042 15.082 −14.256 1.00 42.92 C ATOM 4586 OG1 THR A 640 4.186 16.368 −13.641 1.00 43.48 O ATOM 4587 CG2 THR A 640 5.250 14.816 −15.162 1.00 44.34 C ATOM 4588 C THR A 640 2.537 13.695 −15.717 1.00 40.35 C ATOM 4589 O THR A 640 1.846 12.842 −15.189 1.00 39.51 O ATOM 4590 N PHE A 641 3.122 13.526 −16.899 1.00 41.35 N ATOM 4591 CA PHE A 641 3.334 12.202 −17.488 1.00 41.73 C ATOM 4592 CB PHE A 641 2.030 11.592 −17.992 1.00 39.26 C ATOM 4593 CG PHE A 641 1.426 12.316 −19.152 1.00 39.05 C ATOM 4594 CD1 PHE A 641 0.842 13.573 −18.983 1.00 39.26 C ATOM 4595 CE1 PHE A 641 0.271 14.238 −20.057 1.00 38.29 C ATOM 4596 CZ PHE A 641 0.268 13.645 −21.311 1.00 37.77 C ATOM 4597 CE2 PHE A 641 0.838 12.394 −21.488 1.00 37.99 C ATOM 4598 CD2 PHE A 641 1.410 11.733 −20.412 1.00 37.82 C ATOM 4599 C PHE A 641 4.385 12.228 −18.599 1.00 44.69 C ATOM 4600 O PHE A 641 4.634 13.272 −19.217 1.00 43.37 O ATOM 4601 N ARG A 642 5.001 11.074 −18.841 1.00 47.15 N ATOM 4602 CA ARG A 642 6.055 10.973 −19.829 1.00 49.19 C ATOM 4603 CB ARG A 642 7.202 10.083 −19.322 1.00 51.52 C ATOM 4604 CG ARG A 642 8.236 10.829 −18.478 1.00 55.31 C ATOM 4605 CD ARG A 642 9.663 10.402 −18.830 1.00 60.61 C ATOM 4606 NE ARG A 642 10.666 11.466 −18.641 1.00 60.77 N ATOM 4607 CZ ARG A 642 11.591 11.488 −17.676 1.00 58.54 C ATOM 4608 NH1 ARG A 642 11.669 10.510 −16.783 1.00 55.92 N ATOM 4609 NH2 ARG A 642 12.446 12.498 −17.605 1.00 58.06 N ATOM 4610 C ARG A 642 5.526 10.500 −21.182 1.00 49.76 C ATOM 4611 O ARG A 642 4.832 9.484 −21.259 1.00 48.46 O ATOM 4612 N SER A 643 5.843 11.272 −22.228 1.00 51.04 N ATOM 4613 CA SER A 643 5.563 10.935 −23.636 1.00 53.50 C ATOM 4614 CB SER A 643 4.086 10.588 −23.865 1.00 54.34 C ATOM 4615 C SER A 643 5.953 12.102 −24.538 1.00 55.44 C ATOM 4616 O SER A 643 7.121 12.270 −24.888 1.00 58.95 O ATOM 4617 N SER A 645 9.458 10.222 −24.406 1.00 53.63 N ATOM 4618 CA SER A 645 10.765 10.513 −23.810 1.00 56.71 C ATOM 4619 CB SER A 645 11.808 10.777 −24.902 1.00 54.28 C ATOM 4620 C SER A 645 10.724 11.685 −22.809 1.00 57.78 C ATOM 4621 O SER A 645 11.261 11.586 −21.697 1.00 58.46 O ATOM 4622 N THR A 646 10.077 12.779 −23.210 1.00 56.83 N ATOM 4623 CA THR A 646 10.015 14.009 −22.410 1.00 54.49 C ATOM 4624 CB THR A 646 10.002 15.253 −23.330 1.00 53.55 C ATOM 4625 OG1 THR A 646 10.221 16.428 −22.546 1.00 56.63 O ATOM 4626 CG2 THR A 646 8.681 15.373 −24.115 1.00 51.15 O ATOM 4627 C THR A 646 8.834 14.007 −21.404 1.00 53.23 C ATOM 4628 O THR A 646 8.233 12.962 −21.174 1.00 54.41 O ATOM 4629 N THR A 647 8.524 15.157 −20.799 1.00 50.27 N ATOM 4630 CA THR A 647 7.373 15.273 −19.882 1.00 49.42 C ATOM 4631 CB THR A 647 7.794 15.709 −18.464 1.00 50.84 C ATOM 4632 OG1 THR A 647 8.999 16.482 −18.537 1.00 54.95 O ATOM 4633 CG2 THR A 647 8.031 14.496 −17.580 1.00 52.38 C ATOM 4634 C THR A 647 6.273 16.220 −20.371 1.00 48.16 C ATOM 4635 O THR A 647 6.541 17.342 −20.789 1.00 48.31 O ATOM 4636 N ASN A 648 5.030 15.751 −20.316 1.00 47.79 N ATOM 4637 CA ASN A 648 3.868 16.577 −20.646 1.00 46.43 C ATOM 4638 CB ASN A 648 3.125 16.018 −21.873 1.00 47.29 C ATOM 4639 CG ASN A 648 3.900 16.197 −23.182 1.00 49.78 C ATOM 4640 OD1 ASN A 648 5.120 16.390 −23.195 1.00 50.61 O ATOM 4641 ND2 ASN A 648 3.183 16.115 −24.297 1.00 49.50 N ATOM 4642 C ASN A 648 2.921 16.697 −19.439 1.00 45.51 C ATOM 4643 O ASN A 648 3.113 16.017 −18.413 1.00 43.38 O ATOM 4644 N VAL A 649 1.912 17.565 −19.561 1.00 42.59 N ATOM 4645 CA VAL A 649 0.968 17.822 −18.467 1.00 40.76 C ATOM 4646 CB VAL A 649 1.169 19.230 −17.856 1.00 40.69 C ATOM 4647 CG1 VAL A 649 0.119 19.515 −16.788 1.00 41.78 C ATOM 4648 CG2 VAL A 649 2.566 19.370 −17.268 1.00 40.43 C ATOM 4649 C VAL A 649 −0.491 17.655 −18.899 1.00 38.73 C ATOM 4650 O VAL A 649 −0.920 18.228 −19.888 1.00 39.84 O ATOM 4651 N PHE A 650 −1.246 16.868 −18.142 1.00 37.60 N ATOM 4652 CA PHE A 650 −2.670 16.677 −18.401 1.00 36.68 C ATOM 4653 CB PHE A 650 −3.077 15.242 −18.085 1.00 35.18 C ATOM 4654 CG PHE A 650 −4.253 14.748 −18.875 1.00 33.59 C ATOM 4655 CD1 PHE A 650 −5.556 15.113 −18.526 1.00 34.08 C ATOM 4656 CE1 PHE A 650 −6.650 14.641 −19.255 1.00 33.62 C ATOM 4657 CZ PHE A 650 −6.446 13.787 −20.336 1.00 33.91 C ATOM 4658 CE2 PHE A 650 −5.148 13.407 −20.686 1.00 33.69 C ATOM 4659 CD2 PHE A 650 −4.064 13.885 −19.957 1.00 32.94 C ATOM 4660 C PHE A 650 −3.459 17.615 −17.518 1.00 37.39 C ATOM 4661 O PHE A 650 −3.218 17.694 −16.313 1.00 36.64 O ATOM 4662 N ALA A 651 −4.414 18.312 −18.122 1.00 39.09 N ATOM 4663 CA ALA A 651 −5.225 19.291 −17.411 1.00 40.70 C ATOM 4664 CB ALA A 651 −5.019 20.677 −18.003 1.00 40.70 C ATOM 4665 C ALA A 651 −6.699 18.910 −17.425 1.00 41.92 C ATOM 4666 O ALA A 651 −7.345 18.919 −18.467 1.00 42.06 O ATOM 4667 N CYS A 652 −7.226 18.587 −16.253 1.00 46.12 N ATOM 4668 CA CYS A 652 −8.602 18.139 −16.137 1.00 50.41 C ATOM 4669 CB CYS A 652 −8.723 17.070 −15.053 1.00 50.37 C ATOM 4670 SG CYS A 652 −7.703 15.611 −15.357 1.00 51.52 S ATOM 4671 C CYS A 652 −9.557 19.295 −15.858 1.00 54.45 C ATOM 4672 O CYS A 652 −9.328 20.100 −14.955 1.00 54.85 O ATOM 4673 N SER A 653 −10.612 19.367 −16.666 1.00 58.85 N ATOM 4674 CA SER A 653 −11.737 20.279 −16.469 1.00 60.94 C ATOM 4675 CB SER A 653 −11.340 21.729 −16.783 1.00 61.90 C ATOM 4676 OG SER A 653 −10.811 21.846 −18.092 1.00 63.69 O ATOM 4677 C SER A 653 −12.880 19.816 −17.375 1.00 63.64 C ATOM 4678 O SER A 653 −12.907 18.660 −17.803 1.00 63.83 O ATOM 4679 N ASP A 654 −13.821 20.712 −17.663 1.00 66.74 N ATOM 4680 CA ASP A 654 −14.897 20.425 −18.616 1.00 68.74 C ATOM 4681 CB ASP A 654 −16.003 21.484 −18.526 1.00 75.91 C ATOM 4682 CG ASP A 654 −15.452 22.905 −18.444 1.00 83.99 C ATOM 4683 OD1 ASP A 654 −14.788 23.240 −17.430 1.00 84.86 O ATOM 4684 OD2 ASP A 654 −15.695 23.687 −19.392 1.00 84.83 O ATOM 4685 C ASP A 654 −14.346 20.341 −20.038 1.00 67.13 C ATOM 4686 O ASP A 654 −15.040 19.906 −20.962 1.00 66.04 O ATOM 4687 N ARG A 655 −13.096 20.777 −20.194 1.00 63.77 N ATOM 4688 CA ARG A 655 −12.339 20.611 −21.429 1.00 58.42 C ATOM 4689 CB ARG A 655 −12.306 21.921 −22.229 1.00 56.45 C ATOM 4690 C ARG A 655 −10.926 20.124 −21.082 1.00 52.64 C ATOM 4691 O ARG A 655 −10.068 20.921 −20.701 1.00 54.43 O ATOM 4692 N PRO A 656 −10.694 18.802 −21.178 1.00 48.11 N ATOM 4693 CA PRO A 656 −9.391 18.220 −20.848 1.00 46.19 C ATOM 4694 CB PRO A 656 −9.666 16.714 −20.858 1.00 45.52 C ATOM 4695 CG PRO A 656 −10.836 16.544 −21.764 1.00 46.54 C ATOM 4696 CD PRO A 656 −11.669 17.780 −21.603 1.00 47.27 C ATOM 4697 C PRO A 656 −8.329 18.581 −21.883 1.00 45.12 C ATOM 4698 O PRO A 656 −8.584 18.495 −23.080 1.00 47.73 O ATOM 4699 N THR A 657 −7.147 18.968 −21.420 1.00 42.60 N ATOM 4700 CA THR A 657 −6.123 19.542 −22.285 1.00 43.04 C ATOM 4701 CB THR A 657 −6.037 21.061 −22.058 1.00 42.92 C ATOM 4702 OG1 THR A 657 −7.354 21.596 −21.905 1.00 43.45 O ATOM 4703 CG2 THR A 657 −5.354 21.754 −23.208 1.00 43.14 C ATOM 4704 C THR A 657 −4.753 18.939 −21.991 1.00 44.49 C ATOM 4705 O THR A 657 −4.414 18.691 −20.835 1.00 45.58 O ATOM 4706 N VAL A 658 −3.968 18.696 −23.036 1.00 46.22 N ATOM 4707 CA VAL A 658 −2.560 18.314 −22.872 1.00 46.46 C ATOM 4708 CB VAL A 658 −2.167 17.142 −23.800 1.00 45.20 C ATOM 4709 CG1 VAL A 658 −0.678 16.846 −23.714 1.00 44.11 C ATOM 4710 CG2 VAL A 658 −2.968 15.892 −23.464 1.00 44.44 C ATOM 4711 C VAL A 658 −1.701 19.535 −23.177 1.00 48.08 C ATOM 4712 O VAL A 658 −2.038 20.321 −24.057 1.00 51.92 O ATOM 4713 N ILE A 659 −0.607 19.707 −22.441 1.00 49.43 N ATOM 4714 CA ILE A 659 0.304 20.833 −22.672 1.00 53.38 C ATOM 4715 CB ILE A 659 0.376 21.776 −21.440 1.00 50.33 C ATOM 4716 CG1 ILE A 659 −1.010 21.934 −20.789 1.00 47.99 C ATOM 4717 CD1 ILE A 659 −1.042 22.788 −19.536 1.00 46.40 C ATOM 4718 CG2 ILE A 659 0.942 23.130 −21.840 1.00 49.05 C ATOM 4719 C ILE A 659 1.699 20.309 −23.033 1.00 59.15 C ATOM 4720 O ILE A 659 2.199 19.392 −22.377 1.00 62.41 O ATOM 4721 N TYR A 660 2.314 20.865 −24.082 1.00 64.32 N ATOM 4722 CA TYR A 660 3.678 20.454 −24.475 1.00 70.36 C ATOM 4723 CB TYR A 660 3.661 19.156 −25.312 1.00 72.28 C ATOM 4724 CG TYR A 660 2.716 19.117 −26.517 1.00 75.56 C ATOM 4725 CD1 TYR A 660 2.662 20.167 −27.445 1.00 75.17 C ATOM 4726 CE1 TYR A 660 1.816 20.111 −28.545 1.00 76.72 C ATOM 4727 CZ TYR A 660 1.021 18.983 −28.741 1.00 79.21 C ATOM 4728 OH TYR A 660 0.169 18.905 −29.826 1.00 77.30 O ATOM 4729 CE2 TYR A 660 1.073 17.926 −27.848 1.00 78.10 C ATOM 4730 CD2 TYR A 660 1.919 17.995 −26.752 1.00 76.67 C ATOM 4731 C TYR A 660 4.525 21.538 −25.170 1.00 75.26 C ATOM 4732 O TYR A 660 4.423 22.725 −24.845 1.00 74.87 O ATOM 4733 N SER A 661 5.387 21.088 −26.091 1.00 80.59 N ATOM 4734 CA SER A 661 6.148 21.935 −27.033 1.00 84.17 C ATOM 4735 CB SER A 661 5.444 23.267 −27.322 1.00 84.69 C ATOM 4736 OG SER A 661 6.090 23.982 −28.362 1.00 83.02 O ATOM 4737 C SER A 661 7.612 22.147 −26.650 1.00 86.37 C ATOM 4738 O SER A 661 7.919 22.743 −25.610 1.00 83.83 O ATOM 4739 N SER A 662 8.503 21.658 −27.517 1.00 91.23 N ATOM 4740 CA SER A 662 9.955 21.763 −27.324 1.00 93.53 C ATOM 4741 CB SER A 662 10.656 20.458 −27.731 1.00 90.57 C ATOM 4742 C SER A 662 10.569 22.939 −28.088 1.00 94.09 C ATOM 4743 O SER A 662 11.634 23.436 −27.704 1.00 94.76 O ATOM 4744 N ASN A 663 9.898 23.375 −29.162 1.00 92.49 N ATOM 4745 CA ASN A 663 10.353 24.512 −29.990 1.00 89.11 C ATOM 4746 CB ASN A 663 9.309 24.877 −31.066 1.00 85.95 C ATOM 4747 CG ASN A 663 7.883 24.900 −30.525 1.00 84.18 C ATOM 4748 OD1 ASN A 663 7.063 24.037 −30.858 1.00 80.29 O ATOM 4749 ND2 ASN A 663 7.580 25.891 −29.688 1.00 82.91 N ATOM 4750 C ASN A 663 10.745 25.746 −29.171 1.00 88.17 C ATOM 4751 O ASN A 663 11.545 26.579 −29.637 1.00 86.49 O ATOM 4752 N HIS A 664 10.137 25.851 −27.972 1.00 87.54 N ATOM 4753 CA HIS A 664 10.550 26.766 −26.873 1.00 85.25 C ATOM 4754 CB HIS A 664 11.851 27.535 −27.167 1.00 84.45 C ATOM 4755 CG HIS A 664 13.109 26.688 −27.041 1.00 82.87 C ATOM 4756 ND1 HIS A 664 14.106 26.727 −27.952 1.00 81.32 N ATOM 4757 CE1 HIS A 664 15.081 25.872 −27.588 1.00 78.56 C ATOM 4758 NE2 HIS A 664 14.707 25.278 −26.441 1.00 79.35 N ATOM 4759 CD2 HIS A 664 13.496 25.755 −26.074 1.00 81.56 C ATOM 4760 C HIS A 664 9.431 27.687 −26.434 1.00 83.20 C ATOM 4761 O HIS A 664 9.661 28.698 −25.764 1.00 81.99 O ATOM 4762 N LYS A 665 8.206 27.327 −26.810 1.00 82.52 N ATOM 4763 CA LYS A 665 6.994 27.981 −26.316 1.00 80.96 C ATOM 4764 CB LYS A 665 6.383 28.872 −27.403 1.00 76.52 C ATOM 4765 C LYS A 665 5.984 26.916 −25.853 1.00 81.86 C ATOM 4766 O LYS A 665 5.993 25.791 −26.357 1.00 83.02 O ATOM 4767 N LEU A 666 5.135 27.266 −24.884 1.00 78.82 N ATOM 4768 CA LEU A 666 4.082 26.361 −24.400 1.00 73.06 C ATOM 4769 CB LEU A 666 3.722 26.665 −22.937 1.00 68.19 C ATOM 4770 C LEU A 666 2.840 26.425 −25.309 1.00 70.23 C ATOM 4771 O LEU A 666 2.540 27.472 −25.896 1.00 67.04 O ATOM 4772 N VAL A 667 2.131 25.299 −25.420 1.00 68.43 N ATOM 4773 CA VAL A 667 1.070 25.127 −26.423 1.00 67.65 C ATOM 4774 CB VAL A 667 1.573 24.260 −27.616 1.00 66.94 C ATOM 4775 CG1 VAL A 667 0.420 23.699 −28.437 1.00 64.65 C ATOM 4776 CG2 VAL A 667 2.511 25.063 −28.507 1.00 67.24 C ATOM 4777 C VAL A 667 −0.216 24.529 −25.838 1.00 66.29 C ATOM 4778 O VAL A 667 −0.176 23.570 −25.066 1.00 68.25 O ATOM 4779 N PHE A 668 −1.352 25.111 −26.211 1.00 64.63 N ATOM 4780 CA PHE A 668 −2.657 24.512 −25.931 1.00 63.59 C ATOM 4781 CB PHE A 668 −3.781 25.573 −25.981 1.00 67.92 C ATOM 4782 CG PHE A 668 −3.884 26.330 −27.301 1.00 66.96 C ATOM 4783 CD1 PHE A 668 −4.729 25.879 −28.323 1.00 64.80 C ATOM 4784 CE1 PHE A 668 −4.834 26.574 −29.523 1.00 62.89 C ATOM 4785 CZ PHE A 668 −4.111 27.742 −29.709 1.00 63.30 C ATOM 4786 CE2 PHE A 668 −3.280 28.215 −28.698 1.00 64.40 C ATOM 4787 CD2 PHE A 668 −3.173 27.518 −27.502 1.00 63.95 C ATOM 4788 C PHE A 668 −2.955 23.353 −26.893 1.00 60.16 C ATOM 4789 O PHE A 668 −2.564 23.396 −28.065 1.00 60.90 O ATOM 4790 N SER A 669 −3.644 22.326 −26.392 1.00 52.83 N ATOM 4791 CA SER A 669 −4.082 21.191 −27.213 1.00 48.07 C ATOM 4792 CB SER A 669 −2.911 20.253 −27.525 1.00 47.04 C ATOM 4793 C SER A 669 −5.219 20.415 −26.548 1.00 45.71 C ATOM 4794 O SER A 669 −5.004 19.699 −25.564 1.00 45.09 O ATOM 4795 N ASN A 670 −6.427 20.564 −27.091 1.00 42.81 N ATOM 4796 CA ASN A 670 −7.610 19.858 −26.579 1.00 40.81 C ATOM 4797 CB ASN A 670 −8.916 20.434 −27.168 1.00 38.99 C ATOM 4798 CG ASN A 670 −8.749 20.988 −28.580 1.00 39.42 C ATOM 4799 OD1 ASN A 670 −9.418 21.949 −28.962 1.00 39.03 O ATOM 4800 ND2 ASN A 670 −7.871 20.378 −29.363 1.00 40.63 N ATOM 4801 C ASN A 670 −7.554 18.320 −26.715 1.00 40.39 C ATOM 4802 O ASN A 670 −6.900 17.786 −27.620 1.00 40.49 O ATOM 4803 N VAL A 671 −8.213 17.628 −25.782 1.00 38.99 N ATOM 4804 CA VAL A 671 −8.315 16.165 −25.784 1.00 38.43 C ATOM 4805 CB VAL A 671 −7.986 15.557 −24.392 1.00 38.78 C ATOM 4806 CG1 VAL A 671 −8.155 14.041 −24.387 1.00 38.12 C ATOM 4807 CG2 VAL A 671 −6.573 15.908 −23.968 1.00 40.18 C ATOM 4808 C VAL A 671 −9.734 15.758 −26.191 1.00 38.66 C ATOM 4809 O VAL A 671 −10.718 16.264 −25.645 1.00 40.20 O ATOM 4810 N ASN A 672 −9.826 14.843 −27.149 1.00 36.66 N ATOM 4811 CA ASN A 672 −11.095 14.301 −27.617 1.00 36.47 C ATOM 4812 CB ASN A 672 −10.843 13.582 −28.967 1.00 37.91 C ATOM 4813 CG ASN A 672 −11.877 12.516 −29.298 1.00 39.85 C ATOM 4814 OD1 ASN A 672 −12.802 12.756 −30.081 1.00 39.61 O ATOM 4815 ND2 ASN A 672 −11.701 11.314 −28.730 1.00 39.91 N ATOM 4816 C ASN A 672 −11.844 13.445 −26.542 1.00 35.47 C ATOM 4817 O ASN A 672 −11.981 12.219 −26.668 1.00 33.39 O ATOM 4818 N LEU A 673 −12.320 14.121 −25.488 1.00 35.73 N ATOM 4819 CA LEU A 673 −13.094 13.492 −24.382 1.00 38.09 C ATOM 4820 CB LEU A 673 −12.167 12.840 −23.341 1.00 36.67 C ATOM 4821 CG LEU A 673 −11.728 11.400 −23.570 1.00 34.61 C ATOM 4822 CD1 LEU A 673 −10.896 10.924 −22.400 1.00 34.85 C ATOM 4823 CD2 LEU A 673 −12.932 10.505 −23.775 1.00 33.76 C ATOM 4824 C LEU A 673 −14.021 14.475 −23.663 1.00 38.77 C ATOM 4825 O LEU A 673 −13.702 15.659 −23.542 1.00 38.71 O ATOM 4826 N LYS A 674 −15.143 13.964 −23.154 1.00 41.33 N ATOM 4827 CA LYS A 674 −16.209 14.812 −22.591 1.00 44.82 C ATOM 4828 CB LYS A 674 −17.496 14.011 −22.323 1.00 42.74 C ATOM 4829 C LYS A 674 −15.752 15.569 −21.341 1.00 47.34 C ATOM 4830 O LYS A 674 −15.469 16.765 −21.409 1.00 52.89 O ATOM 4831 N GLU A 675 −15.675 14.884 −20.207 1.00 46.33 N ATOM 4832 CA GLU A 675 −15.235 15.528 −18.978 1.00 45.98 C ATOM 4833 CB GLU A 675 −16.429 16.110 −18.190 1.00 48.08 C ATOM 4834 CG GLU A 675 −16.141 16.416 −16.718 1.00 50.71 C ATOM 4835 CD GLU A 675 −16.934 17.598 −16.174 1.00 52.57 C ATOM 4836 OE1 GLU A 675 −17.859 17.388 −15.356 1.00 53.34 O ATOM 4837 OE2 GLU A 675 −16.627 18.745 −16.558 1.00 54.17 O ATOM 4838 C GLU A 675 −14.435 14.551 −18.138 1.00 45.20 C ATOM 4839 O GLU A 675 −14.929 13.494 −17.747 1.00 48.88 O ATOM 4840 N VAL A 676 −13.185 14.897 −17.888 1.00 40.85 N ATOM 4841 CA VAL A 676 −12.350 14.110 −17.019 1.00 38.56 C ATOM 4842 CB VAL A 676 −11.007 13.774 −17.691 1.00 36.84 C ATOM 4843 CG1 VAL A 676 −10.357 12.577 −17.020 1.00 35.48 C ATOM 4844 CG2 VAL A 676 −11.207 13.499 −19.171 1.00 36.61 C ATOM 4845 C VAL A 676 −12.110 14.965 −15.795 1.00 39.62 C ATOM 4846 O VAL A 676 −11.660 16.109 −15.918 1.00 39.77 O ATOM 4847 N ASN A 677 −12.433 14.426 −14.619 1.00 40.65 N ATOM 4848 CA ASN A 677 −12.183 15.130 −13.351 1.00 40.85 C ATOM 4849 CB ASN A 677 −13.202 14.731 −12.282 1.00 41.27 C ATOM 4850 CG ASN A 677 −14.621 14.680 −12.819 1.00 44.66 C ATOM 4851 OD1 ASN A 677 −14.944 15.324 −13.822 1.00 46.76 O ATOM 4852 ND2 ASN A 677 −15.480 13.908 −12.155 1.00 43.83 N ATOM 4853 C ASN A 677 −10.768 14.900 −12.836 1.00 40.42 C ATOM 4854 O ASN A 677 −10.171 15.802 −12.246 1.00 40.82 O ATOM 4855 N TYR A 678 −10.243 13.693 −13.066 1.00 39.24 N ATOM 4856 CA TYR A 678 −8.924 13.291 −12.572 1.00 39.34 C ATOM 4857 CB TYR A 678 −9.056 12.579 −11.227 1.00 39.52 C ATOM 4858 CG TYR A 678 −9.601 13.451 −10.136 1.00 40.60 C ATOM 4859 CD1 TYR A 678 −8.762 14.303 −9.415 1.00 41.02 C ATOM 4860 CE1 TYR A 678 −9.258 15.116 −8.410 1.00 41.91 C ATOM 4861 CZ TYR A 678 −10.617 15.088 −8.116 1.00 42.99 C ATOM 4862 OH TYR A 678 −11.118 15.894 −7.114 1.00 42.80 O ATOM 4863 CE2 TYR A 678 −11.474 14.254 −8.827 1.00 43.33 C ATOM 4864 CD2 TYR A 678 −10.961 13.439 −9.827 1.00 41.46 C ATOM 4865 C TYR A 678 −8.208 12.359 −13.530 1.00 39.03 C ATOM 4866 O TYR A 678 −8.836 11.507 −14.159 1.00 40.39 O ATOM 4867 N MET A 679 −6.889 12.504 −13.624 1.00 38.15 N ATOM 4868 CA MET A 679 −6.078 11.530 −14.349 1.00 37.06 C ATOM 4869 CB MET A 679 −5.849 11.967 −15.797 1.00 37.34 C ATOM 4870 CG MET A 679 −4.726 12.970 −15.995 1.00 39.48 C ATOM 4871 SD MET A 679 −3.075 12.260 −16.223 1.00 44.39 S ATOM 4872 CE MET A 679 −3.411 10.956 −17.392 1.00 41.47 C ATOM 4873 C MET A 679 −4.754 11.228 −13.657 1.00 36.61 C ATOM 4874 O MET A 679 −4.320 11.962 −12.765 1.00 36.77 O ATOM 4875 N CYS A 680 −4.134 10.129 −14.081 1.00 36.02 N ATOM 4876 CA CYS A 680 −2.794 9.734 −13.655 1.00 34.56 C ATOM 4877 CB CYS A 680 −2.854 9.012 −12.313 1.00 36.18 C ATOM 4878 SG CYS A 680 −3.274 7.267 −12.445 1.00 37.17 S ATOM 4879 C CYS A 680 −2.196 8.808 −14.708 1.00 32.58 C ATOM 4880 O CYS A 680 −2.936 8.186 −15.482 1.00 32.68 O ATOM 4881 N PRO A 681 −0.860 8.724 −14.764 1.00 30.87 N ATOM 4882 CA PRO A 681 −0.211 7.785 −15.685 1.00 30.89 C ATOM 4883 CB PRO A 681 1.225 8.282 −15.748 1.00 29.96 C ATOM 4884 CG PRO A 681 1.416 9.070 −14.505 1.00 30.43 C ATOM 4885 CD PRO A 681 0.093 9.659 −14.151 1.00 30.58 C ATOM 4886 C PRO A 681 −0.256 6.357 −15.161 1.00 31.71 C ATOM 4887 O PRO A 681 −0.321 6.147 −13.949 1.00 32.99 O ATOM 4888 N LEU A 682 −0.250 5.385 −16.068 1.00 31.61 N ATOM 4889 CA LEU A 682 −0.307 3.978 −15.677 1.00 32.18 C ATOM 4890 CB LEU A 682 −1.750 3.474 −15.584 1.00 32.10 C ATOM 4891 CG LEU A 682 −1.936 2.005 −15.188 1.00 32.39 C ATOM 4892 CD1 LEU A 682 −1.361 1.723 −13.804 1.00 33.60 C ATOM 4893 CD2 LEU A 682 −3.401 1.606 −15.241 1.00 32.38 C ATOM 4894 C LEU A 682 0.472 3.128 −16.645 1.00 33.07 C ATOM 4895 O LEU A 682 0.166 3.083 −17.835 1.00 34.33 O ATOM 4896 N ASN A 683 1.488 2.457 −16.119 1.00 33.59 N ATOM 4897 CA ASN A 683 2.361 1.623 −16.913 1.00 33.83 C ATOM 4898 CB ASN A 683 3.765 2.233 −16.958 1.00 34.36 C ATOM 4899 CG ASN A 683 4.760 1.384 −17.735 1.00 35.28 C ATOM 4900 OD1 ASN A 683 4.406 0.682 −18.696 1.00 35.68 O ATOM 4901 ND2 ASN A 683 6.022 1.457 −17.328 1.00 34.06 N ATOM 4902 C ASN A 683 2.374 0.231 −16.314 1.00 33.22 C ATOM 4903 O ASN A 683 2.927 0.014 −15.247 1.00 32.70 O ATOM 4904 N SER A 684 1.748 −0.706 −17.012 1.00 34.52 N ATOM 4905 CA SER A 684 1.508 −2.032 −16.468 1.00 35.84 C ATOM 4906 CB SER A 684 0.041 −2.168 −16.089 1.00 35.28 C ATOM 4907 CG SER A 684 −0.430 −0.947 −15.562 1.00 36.05 O ATOM 4908 C SER A 684 1.880 −3.151 −17.426 1.00 37.13 C ATOM 4909 O SER A 684 2.014 −2.946 −18.638 1.00 35.79 O ATOM 4910 N ASP A 685 2.036 −4.341 −16.853 1.00 40.41 N ATOM 4911 CA ASP A 685 2.179 −5.586 −17.610 1.00 41.45 C ATOM 4912 CB ASP A 685 2.348 −6.778 −16.655 1.00 43.80 C ATOM 4913 CG ASP A 685 1.358 −6.747 −15.489 1.00 48.23 C ATOM 4914 OD1 ASP A 685 1.363 −5.763 −14.702 1.00 48.65 O ATOM 4915 OD2 ASP A 685 0.575 −7.715 −15.360 1.00 51.26 O ATOM 4916 C ASP A 685 0.978 −5.801 −18.530 1.00 39.37 C ATOM 4917 O ASP A 685 1.042 −6.576 −19.477 1.00 39.72 O ATOM 4918 N GLY A 686 −0.111 −5.096 −18.251 1.00 38.14 N ATOM 4919 CA GLY A 686 −1.288 −5.148 −19.103 1.00 37.01 C ATOM 4920 C GLY A 686 −1.537 −3.877 −19.890 1.00 35.11 C ATOM 4921 O GLY A 686 −2.053 −3.923 −21.005 1.00 34.76 O ATOM 4922 N TYR A 687 −1.177 −2.739 −19.304 1.00 33.93 N ATOM 4923 CA TYR A 687 −1.489 −1.453 −19.899 1.00 32.40 C ATOM 4924 CB TYR A 687 −2.609 −0.787 −19.116 1.00 32.37 C ATOM 4925 CG TYR A 687 −3.858 −1.630 −19.002 1.00 33.25 C ATOM 4926 CD1 TYR A 687 −4.593 −1.989 −20.135 1.00 33.26 C ATOM 4927 CE1 TYR A 687 −5.744 −2.757 −20.030 1.00 34.00 C ATOM 4928 CZ TYR A 687 −6.179 −3.168 −18.775 1.00 34.63 C ATOM 4929 OH TYR A 687 −7.321 −3.921 −18.650 1.00 36.40 O ATOM 4930 CE2 TYR A 687 −5.472 −2.824 −17.641 1.00 34.31 C ATOM 4931 CD2 TYR A 687 −4.316 −2.060 −17.757 1.00 34.42 C ATOM 4932 C TYR A 687 −0.272 −0.547 −19.961 1.00 31.31 C ATOM 4933 O TYR A 687 −0.157 0.380 −19.170 1.00 31.11 O ATOM 4934 N PRO A 688 0.633 −0.804 −20.923 1.00 31.06 N ATOM 4935 CA PRO A 688 1.935 −0.145 −20.963 1.00 31.51 C ATOM 4936 CB PRO A 688 2.752 −1.018 −21.930 1.00 30.81 C ATOM 4937 CG PRO A 688 1.823 −2.068 −22.444 1.00 30.72 C ATOM 4938 CD PRO A 688 0.428 −1.653 −22.102 1.00 30.68 C ATOM 4939 C PRO A 688 1.829 1.264 −21.500 1.00 31.45 C ATOM 4940 O PRO A 688 1.146 1.484 −22.495 1.00 29.70 O ATOM 4941 N ASP A 689 2.501 2.203 −20.833 1.00 33.61 N ATOM 4942 CA ASP A 689 2.479 3.631 −21.209 1.00 36.33 C ATOM 4943 CB ASP A 689 3.293 3.880 −22.498 1.00 36.44 C ATOM 4944 CG ASP A 689 4.697 3.279 −22.439 1.00 37.59 C ATOM 4945 OD2 ASP A 689 4.866 2.109 −22.841 1.00 38.23 O ATOM 4946 OD1 ASP A 689 5.634 3.972 −21.992 1.00 38.63 O ATOM 4947 C ASP A 689 1.037 4.164 −21.359 1.00 36.59 C ATOM 4948 O ASP A 689 0.749 5.026 −22.216 1.00 36.92 O ATOM 4949 N SER A 690 0.139 3.643 −20.526 1.00 34.12 N ATOM 4950 CA SER A 690 −1.267 3.975 −20.630 1.00 34.11 C ATOM 4951 CB SER A 690 −2.125 2.731 −20.426 1.00 34.83 C ATOM 4952 OG SER A 690 −1.908 1.796 −21.463 1.00 37.22 O ATOM 4953 C SER A 690 −1.673 5.051 −19.644 1.00 34.54 C ATOM 4954 O SER A 690 −0.827 5.674 −18.991 1.00 36.34 O ATOM 4955 N LEU A 691 −2.984 5.234 −19.524 1.00 33.71 N ATOM 4956 CA LEU A 691 −3.576 6.317 −18.770 1.00 32.55 C ATOM 4957 CB LEU A 691 −4.174 7.301 −19.757 1.00 32.54 C ATOM 4958 CG LEU A 691 −3.673 8.721 −19.660 1.00 33.63 C ATOM 4959 CD1 LEU A 691 −2.151 8.717 −19.586 1.00 35.64 C ATOM 4960 CD2 LEU A 691 −4.170 9.522 −20.851 1.00 33.02 C ATOM 4961 C LEU A 691 −4.701 5.764 −17.913 1.00 33.00 C ATOM 4962 O LEU A 691 −5.316 4.754 −18.267 1.00 34.02 O ATOM 4963 N ALA A 692 −4.987 6.430 −16.800 1.00 31.36 N ATOM 4964 CA ALA A 692 −6.208 6.160 −16.054 1.00 29.83 C ATOM 4965 CB ALA A 692 −5.877 5.634 −14.676 1.00 30.19 C ATOM 4966 C ALA A 692 −7.020 7.436 −15.956 1.00 29.73 C ATOM 4967 O ALA A 692 −6.570 8.406 −15.373 1.00 30.45 O ATOM 4968 N LEU A 693 −8.208 7.439 −16.548 1.00 30.65 N ATOM 4969 CA LEU A 693 −9.083 8.616 −16.543 1.00 31.90 C ATOM 4970 CB LEU A 693 −9.588 8.925 −17.959 1.00 33.46 C ATOM 4971 CG LEU A 693 −8.662 9.360 −19.103 1.00 34.64 C ATOM 4972 CD1 LEU A 693 −7.834 10.594 −18.755 1.00 34.88 C ATOM 4973 CD2 LEU A 693 −7.769 8.213 −19.558 1.00 36.11 C ATOM 4974 C LEU A 693 −10.292 8.383 −15.650 1.00 32.05 C ATOM 4975 O LEU A 693 −10.978 7.366 −15.778 1.00 32.24 O ATOM 4976 N ALA A 694 −10.567 9.324 −14.754 1.00 31.83 N ATOM 4977 CA ALA A 694 −11.754 9.222 −13.901 1.00 31.80 C ATOM 4978 CB ALA A 694 −11.370 9.008 −12.444 1.00 31.84 C ATOM 4979 C ALA A 694 −12.646 10.435 −14.033 1.00 31.43 C ATOM 4980 O ALA A 694 −12.192 11.578 −13.917 1.00 30.62 O ATOM 4981 N ASN A 695 −13.917 10.182 −14.297 1.00 31.42 N ATOM 4982 CA ASN A 695 −14.906 11.218 −14.165 1.00 32.81 C ATOM 4983 CB ASN A 695 −15.655 11.452 −15.485 1.00 31.83 C ATOM 4984 CG ASN A 695 −16.587 10.313 −15.865 1.00 31.90 C ATOM 4985 OD1 ASN A 695 −16.950 9.452 −15.048 1.00 32.18 O ATOM 4986 ND2 ASN A 695 −17.007 10.323 −17.118 1.00 31.46 N ATOM 4987 C ASN A 695 −15.840 10.940 −12.990 1.00 34.94 C ATOM 4988 O ASN A 695 −15.455 10.268 −12.020 1.00 35.07 O ATOM 4989 N ASN A 696 −17.065 11.447 −13.087 1.00 37.17 N ATOM 4990 CA ASN A 696 −18.014 11.378 −11.993 1.00 38.25 C ATOM 4991 CB ASN A 696 −19.134 12.396 −12.180 1.00 40.39 C ATOM 4992 CG ASN A 696 −18.853 13.685 −11.447 1.00 42.20 C ATOM 4993 OD1 ASN A 696 −18.609 14.727 −12.058 1.00 43.14 O ATOM 4994 ND2 ASN A 696 −18.838 13.610 −10.120 1.00 44.02 N ATOM 4995 C ASN A 696 −18.566 10.005 −11.704 1.00 37.80 C ATOM 4996 O ASN A 696 −18.850 9.692 −10.547 1.00 38.84 O ATOM 4997 N SER A 697 −18.703 9.175 −12.735 1.00 36.76 N ATOM 4998 CA SER A 697 −19.219 7.824 −12.506 1.00 36.76 C ATOM 4999 CB SER A 697 −20.702 7.705 −12.911 1.00 36.57 C ATOM 5000 OG SER A 697 −20.889 7.854 −14.305 1.00 36.73 O ATOM 5001 C SER A 697 −18.372 6.665 −13.061 1.00 36.12 C ATOM 5002 O SER A 697 −18.704 5.498 −12.820 1.00 36.34 O ATOM 5003 N THR A 698 −17.267 6.974 −13.751 1.00 33.66 N ATOM 5004 CA THR A 698 −16.439 5.923 −14.356 1.00 32.53 C ATOM 5005 CB THR A 698 −16.803 5.747 −15.836 1.00 32.48 C ATOM 5006 OG1 THR A 698 −18.225 5.771 −15.977 1.00 33.25 O ATOM 5007 CG2 THR A 698 −16.278 4.430 −16.368 1.00 32.34 C ATOM 5008 C THR A 698 −14.923 6.136 −14.253 1.00 32.41 C ATOM 5009 O THR A 698 −14.438 7.256 −14.392 1.00 34.00 O ATOM 5010 N LEU A 699 −14.178 5.056 −14.010 1.00 31.82 N ATOM 5011 CA LEU A 699 −12.719 5.062 −14.230 1.00 30.87 C ATOM 5012 CB LEU A 699 −11.949 4.350 −13.100 1.00 31.18 C ATOM 5013 C LEU A 699 −12.452 4.380 −15.555 1.00 29.03 C ATOM 5014 O LEU A 699 −13.046 3.341 −15.846 1.00 28.63 O ATOM 5015 N THR A 700 −11.585 4.986 −16.367 1.00 28.29 N ATOM 5016 CA THR A 700 −11.205 4.435 −17.679 1.00 27.38 C ATOM 5017 CB THR A 700 −11.656 5.327 −18.877 1.00 27.04 C ATOM 5018 OG1 THR A 700 −12.926 5.932 −18.614 1.00 27.05 O ATOM 5019 CG2 THR A 700 −11.784 4.503 −20.140 1.00 27.30 C ATOM 5020 C THR A 700 −9.689 4.278 −17.735 1.00 26.68 C ATOM 5021 O THR A 700 −8.954 5.171 −17.292 1.00 25.83 O ATOM 5022 N ILE A 701 −9.229 3.138 −18.259 1.00 25.67 N ATOM 5023 CA ILE A 701 −7.809 2.929 −18.533 1.00 25.26 C ATOM 5024 CB ILE A 701 −7.296 1.623 −17.905 1.00 25.47 C ATOM 5025 CG1 ILE A 701 −7.429 1.700 −16.376 1.00 26.75 C ATOM 5026 CD1 ILE A 701 −6.982 0.464 −15.609 1.00 27.48 C ATOM 5027 CG2 ILE A 701 −5.854 1.364 −18.316 1.00 24.87 C ATOM 5028 C ILE A 701 −7.572 2.929 −20.030 1.00 24.71 C ATOM 5029 O ILE A 701 −8.194 2.160 −20.750 1.00 24.32 O ATOM 5030 N GLY A 702 −6.687 3.803 −20.505 1.00 25.58 N ATOM 5031 CA GLY A 702 −6.463 3.934 −21.955 1.00 28.01 C ATOM 5032 C GLY A 702 −5.050 4.280 −22.390 1.00 29.39 C ATOM 5033 O GLY A 702 −4.298 4.877 −21.627 1.00 30.37 O ATOM 5034 N THR A 703 −4.678 3.870 −23.608 1.00 30.52 N ATOM 5035 CA THR A 703 −3.474 4.400 −24.278 1.00 31.06 C ATOM 5036 CB THR A 703 −2.864 3.405 −25.283 1.00 28.99 C ATOM 5037 C THR A 703 −3.831 5.719 −24.974 1.00 31.54 C ATOM 5038 O THR A 703 −4.997 6.052 −25.121 1.00 31.64 O ATOM 5039 N ILE A 704 −2.835 6.482 −25.384 1.00 33.23 N ATOM 5040 CA ILE A 704 −3.100 7.833 −25.860 1.00 35.09 C ATOM 5041 CB ILE A 704 −2.762 8.863 −24.761 1.00 34.91 C ATOM 5042 CG1 ILE A 704 −2.698 10.286 −25.323 1.00 34.69 C ATOM 5043 CD1 ILE A 704 −2.731 11.368 −24.258 1.00 33.31 C ATOM 5044 CG2 ILE A 704 −1.477 8.464 −24.032 1.00 36.26 C ATOM 5045 C ILE A 704 −2.339 8.106 −27.153 1.00 37.31 C ATOM 5046 O ILE A 704 −1.122 7.950 −27.192 1.00 38.69 O ATOM 5047 N ASP A 705 −3.070 8.467 −28.212 1.00 38.52 N ATOM 5048 CA ASP A 705 −2.487 8.874 −29.489 1.00 40.13 C ATOM 5049 CB ASP A 705 −3.534 9.619 −30.314 1.00 42.73 C ATOM 5050 CG ASP A 705 −4.311 8.712 −31.253 1.00 45.89 C ATOM 5051 OD1 ASP A 705 −3.707 8.157 −32.205 1.00 48.35 O ATOM 5052 OD2 ASP A 705 −5.542 8.595 −31.067 1.00 46.21 O ATOM 5053 C ASP A 705 −1.299 9.812 −29.268 1.00 42.29 C ATOM 5054 O ASP A 705 −1.363 10.716 −28.423 1.00 42.76 O ATOM 5055 N GLU A 706 −0.219 9.605 −30.020 1.00 43.67 N ATOM 5056 CA GLU A 706 0.963 10.475 −29.908 1.00 45.79 C ATOM 5057 CB GLU A 706 2.194 9.828 −30.563 1.00 46.67 C ATOM 5058 C GLU A 706 0.702 11.882 −30.485 1.00 45.70 C ATOM 5059 O GLU A 706 0.869 12.884 −29.785 1.00 45.52 O ATOM 5060 N ILE A 707 0.269 11.931 −31.748 1.00 45.11 N ATOM 5061 CA ILE A 707 −0.050 13.183 −32.462 1.00 44.00 C ATOM 5062 CB ILE A 707 0.398 13.110 −33.947 1.00 42.49 C ATOM 5063 CG1 ILE A 707 0.152 11.696 −34.505 1.00 40.72 C ATOM 5064 CD1 ILE A 707 0.803 11.405 −35.835 1.00 39.67 C ATOM 5065 CG2 ILE A 707 1.845 13.562 −34.091 1.00 42.82 C ATOM 5066 C ILE A 707 −1.545 13.527 −32.451 1.00 43.94 C ATOM 5067 O ILE A 707 −2.397 12.642 −32.327 1.00 43.61 O ATOM 5068 N GLN A 708 −1.853 14.816 −32.608 1.00 43.70 N ATOM 5069 CA GLN A 708 −3.221 15.261 −32.879 1.00 42.42 C ATOM 5070 CB GLN A 708 −3.311 16.794 −32.910 1.00 43.71 C ATOM 5071 CG GLN A 708 −3.151 17.461 −31.547 1.00 47.33 C ATOM 5072 CD GLN A 708 −3.709 18.881 −31.497 1.00 48.95 C ATOM 5073 OE1 GLN A 708 −3.256 19.763 −32.223 1.00 48.82 O ATOM 5074 NE2 GLN A 708 −4.683 19.109 −30.612 1.00 50.04 N ATOM 5075 C GLN A 708 −3.720 14.666 −34.201 1.00 41.42 C ATOM 5076 O GLN A 708 −2.948 14.076 −34.960 1.00 42.27 O ATOM 5077 N LYS A 709 −5.013 14.821 −34.466 1.00 39.19 N ATOM 5078 CA LYS A 709 −5.658 14.222 −35.631 1.00 34.64 C ATOM 5079 CB LYS A 709 −5.709 12.693 −35.476 1.00 36.61 C ATOM 5080 CG LYS A 709 −5.948 11.927 −36.764 1.00 38.57 C ATOM 5081 CD LYS A 709 −6.075 10.429 −36.526 1.00 39.66 C ATOM 5082 CE LYS A 709 −6.115 9.666 −37.849 1.00 41.22 C ATOM 5083 NZ LYS A 709 −4.928 9.953 −38.717 1.00 39.87 N ATOM 5084 C LYS A 709 −7.066 14.789 −35.705 1.00 31.13 C ATOM 5085 O LYS A 709 −7.488 15.516 −34.795 1.00 30.31 O ATOM 5086 N LEU A 710 −7.782 14.473 −36.786 1.00 27.12 N ATOM 5087 CA LEU A 710 −9.173 14.894 −36.956 1.00 23.55 C ATOM 5088 CB LEU A 710 −9.454 15.292 −38.400 1.00 22.74 C ATOM 5089 CG LEU A 710 −9.112 16.695 −38.876 1.00 22.36 C ATOM 5090 CD1 LEU A 710 −9.868 16.956 −40.173 1.00 22.06 C ATOM 5091 CD2 LEU A 710 −9.488 17.723 −37.830 1.00 22.50 C ATOM 5092 C LEU A 710 −10.140 13.807 −36.557 1.00 21.29 C ATOM 5093 O LEU A 710 −10.171 12.748 −37.155 1.00 21.27 O ATOM 5094 N HIS A 711 −10.957 14.079 −35.563 1.00 19.47 N ATOM 5095 CA HIS A 711 −11.869 13.074 −35.096 1.00 18.74 C ATOM 5096 CB HIS A 711 −11.843 13.028 −33.570 1.00 19.32 C ATOM 5097 CG HIS A 711 −10.519 12.552 −33.026 1.00 20.32 C ATOM 5098 ND1 HIS A 711 −9.444 13.353 −32.944 1.00 20.66 N ATOM 5099 CE1 HIS A 711 −8.389 12.645 −32.485 1.00 20.72 C ATOM 5100 NE2 HIS A 711 −8.791 11.381 −32.288 1.00 20.87 N ATOM 5101 CD2 HIS A 711 −10.094 11.282 −32.623 1.00 20.80 C ATOM 5102 C HIS A 711 −13.225 13.300 −35.668 1.00 17.84 C ATOM 5103 O HIS A 711 −13.898 14.260 −35.323 1.00 17.77 O ATOM 5104 N ILE A 712 −13.629 12.433 −36.590 1.00 17.23 N ATOM 5105 CA ILE A 712 −14.937 12.577 −37.237 1.00 16.75 C ATOM 5106 CB ILE A 712 −14.844 12.452 −38.776 1.00 16.67 C ATOM 5107 CG1 ILE A 712 −13.748 13.355 −39.328 1.00 16.81 C ATOM 5108 CD1 ILE A 712 −13.157 12.859 −40.629 1.00 17.08 C ATOM 5109 CG2 ILE A 712 −16.155 12.860 −39.428 1.00 16.87 C ATOM 5110 C ILE A 712 −15.947 11.572 −36.684 1.00 16.21 C ATOM 5111 O ILE A 712 −15.713 10.373 −36.736 1.00 16.64 O ATOM 5112 N ARG A 713 −17.053 12.076 −36.141 1.00 15.67 N ATOM 5113 CA ARG A 713 −18.161 11.249 −35.648 1.00 15.37 C ATOM 5114 CB ARG A 713 −18.775 11.900 −34.403 1.00 15.64 C ATOM 5115 CG ARG A 713 −19.453 10.962 −33.431 1.00 15.90 C ATOM 5116 CD ARG A 713 −20.947 10.895 −33.664 1.00 16.99 C ATOM 5117 NE ARG A 713 −21.584 9.754 −32.976 1.00 18.10 N ATOM 5118 CZ ARG A 713 −21.983 9.759 −31.700 1.00 18.29 C ATOM 5119 NH1 ARG A 713 −21.814 10.843 −30.941 1.00 18.69 N ATOM 5120 NH2 ARG A 713 −22.546 8.680 −31.177 1.00 17.89 N ATOM 5121 C ARG A 713 −19.200 11.210 −36.752 1.00 15.05 C ATOM 5122 O ARG A 713 −19.515 12.249 −37.327 1.00 15.50 O ATOM 5123 N THR A 714 −19.736 10.038 −37.066 1.00 14.09 N ATOM 5124 CA THR A 714 −20.731 9.967 −38.122 1.00 13.51 C ATOM 5125 CB THR A 714 −20.303 9.000 −39.215 1.00 13.64 C ATOM 5126 OG1 THR A 714 −19.082 9.474 −39.791 1.00 13.91 O ATOM 5127 CG2 THR A 714 −21.376 8.883 −40.303 1.00 13.57 C ATOM 5128 C THR A 714 −22.114 9.618 −37.616 1.00 13.32 C ATOM 5129 O THR A 714 −22.302 8.609 −36.952 1.00 13.47 O ATOM 5130 N VAL A 715 −23.079 10.477 −37.918 1.00 13.10 N ATOM 5131 CA VAL A 715 −24.463 10.234 −37.553 1.00 12.89 C ATOM 5132 CB VAL A 715 −25.066 11.451 −36.831 1.00 12.97 C ATOM 5133 CG1 VAL A 715 −26.447 11.135 −36.285 1.00 13.09 C ATOM 5134 CG2 VAL A 715 −24.157 11.898 −35.704 1.00 13.11 C ATOM 5135 C VAL A 715 −25.271 9.894 −38.814 1.00 12.94 C ATOM 5136 O VAL A 715 −25.829 10.793 −39.459 1.00 12.68 O ATOM 5137 N PRO A 716 −25.315 8.587 −39.187 1.00 12.88 N ATOM 5138 CA PRO A 716 −26.088 8.174 −40.354 1.00 12.39 C ATOM 5139 CB PRO A 716 −26.058 6.648 −40.259 1.00 12.33 C ATOM 5140 CG PRO A 716 −24.805 6.341 −39.520 1.00 12.38 C ATOM 5141 CD PRO A 716 −24.691 7.430 −38.509 1.00 12.59 C ATOM 5142 C PRO A 716 −27.509 8.650 −40.192 1.00 12.29 C ATOM 5143 O PRO A 716 −28.075 8.489 −39.098 1.00 12.26 O ATOM 5144 N LEU A 717 −28.076 9.233 −41.255 1.00 11.98 N ATOM 5145 CA LEU A 717 −29.507 9.618 −41.281 1.00 11.73 C ATOM 5146 CB LEU A 717 −29.673 11.098 −41.609 1.00 11.17 C ATOM 5147 CG LEU A 717 −29.070 12.161 −40.714 1.00 10.80 C ATOM 5148 CD1 LEU A 717 −28.987 13.452 −41.507 1.00 10.59 C ATOM 5149 CD2 LEU A 717 −29.881 12.339 −39.441 1.00 10.70 C ATOM 5150 C LEU A 717 −30.372 8.811 −42.258 1.00 11.91 C ATOM 5151 O LEU A 717 −31.601 8.834 −42.163 1.00 12.27 O ATOM 5152 N TYR A 718 −29.735 8.134 −43.211 1.00 12.13 N ATOM 5153 CA TYR A 718 −30.436 7.347 −44.251 1.00 12.39 C ATOM 5154 CB TYR A 718 −31.108 6.112 −43.642 1.00 11.98 C ATOM 5155 CG TYR A 718 −30.153 5.326 −42.786 1.00 11.70 C ATOM 5156 CD1 TYR A 718 −29.004 4.766 −43.336 1.00 11.90 C ATOM 5157 CE1 TYR A 718 −28.101 4.063 −42.559 1.00 11.71 C ATOM 5158 CZ TYR A 718 −28.341 3.922 −41.223 1.00 11.57 C ATOM 5159 OH TYR A 718 −27.452 3.224 −40.471 1.00 11.65 O ATOM 5160 CE2 TYR A 718 −29.467 4.471 −40.645 1.00 11.58 C ATOM 5161 CD2 TYR A 718 −30.361 5.179 −41.427 1.00 11.55 C ATOM 5162 C TYR A 718 −31.411 8.168 −45.103 1.00 12.88 C ATOM 5163 O TYR A 718 −32.361 7.626 −45.676 1.00 13.25 O ATOM 5164 N GLU A 719 −31.158 9.480 −45.166 1.00 13.19 N ATOM 5165 CA GLU A 719 −31.836 10.407 −46.081 1.00 13.39 C ATOM 5166 CB GLU A 719 −33.200 10.843 −45.547 1.00 14.01 C ATOM 5167 CG GLU A 719 −33.322 10.773 −44.044 1.00 15.49 C ATOM 5168 CD GLU A 719 −34.540 11.503 −43.514 1.00 16.67 C ATOM 5169 OE1 GLU A 719 −34.461 12.738 −43.380 1.00 17.60 O ATOM 5170 OE2 GLU A 719 −35.562 10.844 −43.202 1.00 17.18 O ATOM 5171 C GLU A 719 −30.944 11.618 −46.305 1.00 13.18 C ATOM 5172 O GLU A 719 −29.973 11.818 −45.580 1.00 12.93 O ATOM 5173 N SER A 720 −31.276 12.420 −47.313 1.00 13.03 N ATOM 5174 CA SER A 720 −30.535 13.639 −47.618 1.00 12.98 C ATOM 5175 CB SER A 720 −30.942 14.148 −48.994 1.00 12.94 C ATOM 5176 OG SER A 720 −30.637 13.212 −49.993 1.00 13.21 O ATOM 5177 C SER A 720 −30.740 14.771 −46.595 1.00 13.16 C ATOM 5178 O SER A 720 −31.831 15.341 −46.526 1.00 13.27 O ATOM 5179 N PRO A 721 −29.690 15.117 −45.812 1.00 13.35 N ATOM 5180 CA PRO A 721 −29.703 16.367 −45.030 1.00 13.50 C ATOM 5181 CB PRO A 721 −28.528 16.192 −44.076 1.00 13.38 C ATOM 5182 CG PRO A 721 −27.582 15.327 −44.841 1.00 13.63 C ATOM 5183 CD PRO A 721 −28.458 14.347 −45.574 1.00 13.39 C ATOM 5184 C PRO A 721 −29.438 17.552 −45.935 1.00 13.75 C ATOM 5185 O PRO A 721 −28.632 17.455 −46.854 1.00 13.80 O ATOM 5186 N ARG A 722 −30.103 18.668 −45.677 1.00 14.29 N ATOM 5187 CA ARG A 722 −30.073 19.777 −46.621 1.00 14.56 C ATOM 5188 CB ARG A 722 −31.421 19.927 −47.301 1.00 14.97 C ATOM 5189 CG ARG A 722 −31.768 18.775 −48.236 1.00 15.21 C ATOM 5190 CD ARG A 722 −31.609 19.217 −49.672 1.00 15.75 C ATOM 5191 NE ARG A 722 −30.300 18.884 −50.232 1.00 15.88 N ATOM 5192 CZ ARG A 722 −29.635 19.642 −51.109 1.00 15.99 C ATOM 5193 NH1 ARG A 722 −28.472 19.228 −51.587 1.00 15.81 N ATOM 5194 NH2 ARG A 722 −30.120 20.817 −51.505 1.00 16.01 N ATOM 5195 C ARG A 722 −29.645 21.077 −45.992 1.00 14.53 C ATOM 5196 O ARG A 722 −28.922 21.848 −46.618 1.00 15.17 O ATOM 5197 N LYS A 723 −30.085 21.330 −44.765 1.00 14.10 N ATOM 5198 CA LYS A 723 −29.576 22.470 −43.991 1.00 13.80 C ATOM 5199 CB LYS A 723 −30.492 23.701 −44.102 1.00 14.05 C ATOM 5200 CG LYS A 723 −30.836 24.143 −45.513 1.00 14.08 C ATOM 5201 CD LYS A 723 −29.706 24.904 −46.177 1.00 14.24 C ATOM 5202 CE LYS A 723 −29.832 24.744 −47.683 1.00 14.56 C ATOM 5203 NZ LYS A 723 −29.195 25.861 −48.428 1.00 14.90 N ATOM 5204 C LYS A 723 −29.427 22.097 −42.535 1.00 13.21 C ATOM 5205 O LYS A 723 −30.096 21.193 −42.047 1.00 12.64 O ATOM 5206 N ILE A 724 −28.546 22.811 −41.850 1.00 13.11 N ATOM 5207 CA ILE A 724 −28.280 22.581 −40.441 1.00 13.39 C ATOM 5208 CB ILE A 724 −26.982 21.745 −40.193 1.00 13.25 C ATOM 5209 CG1 ILE A 724 −26.857 21.399 −38.702 1.00 13.09 C ATOM 5210 CD1 ILE A 724 −26.178 20.092 −38.393 1.00 13.04 C ATOM 5211 CG2 ILE A 724 −25.732 22.483 −40.681 1.00 12.67 C ATOM 5212 C ILE A 724 −28.107 23.933 −39.829 1.00 13.51 C ATOM 5213 O ILE A 724 −27.620 24.824 −40.491 1.00 13.82 O ATOM 5214 N CYS A 725 −28.516 24.089 −38.579 0.50 13.89 N ATOM 5215 CA CYS A 725 −28.166 25.262 −37.812 0.50 14.54 C ATOM 5216 CB CYS A 725 −29.159 26.391 −38.048 0.50 14.32 C ATOM 5217 SG CYS A 725 −30.786 26.044 −37.371 0.50 14.65 S ATOM 5218 C CYS A 725 −28.178 24.814 −36.380 0.50 15.23 C ATOM 5219 O CYS A 725 −28.763 23.788 −36.061 0.50 15.14 O ATOM 5220 N TYR A 726 −27.518 25.570 −35.517 1.00 16.68 N ATOM 5221 CA TYR A 726 −27.259 25.110 −34.156 1.00 18.93 C ATOM 5222 CB TYR A 726 −25.737 25.015 −33.893 1.00 19.94 C ATOM 5223 CG TYR A 726 −25.363 24.880 −32.425 1.00 20.43 C ATOM 5224 CD1 TYR A 726 −25.911 23.867 −31.635 1.00 20.76 C ATOM 5225 CE1 TYR A 726 −25.592 23.752 −30.298 1.00 21.62 C ATOM 5226 CZ TYR A 726 −24.703 24.649 −29.729 1.00 22.23 C ATOM 5227 OH TYR A 726 −24.381 24.527 −28.393 1.00 23.06 O ATOM 5228 CE2 TYR A 726 −24.137 25.654 −30.494 1.00 21.58 C ATOM 5229 CD2 TYR A 726 −24.470 25.764 −31.832 1.00 20.62 C ATOM 5230 C TYR A 726 −27.938 25.966 −33.087 1.00 20.27 C ATOM 5231 O TYR A 726 −27.612 27.141 −32.922 1.00 22.38 O ATOM 5232 N GLN A 727 −28.854 25.370 −32.336 1.00 20.29 N ATOM 5233 CA GLN A 727 −29.546 26.107 −31.309 1.00 21.59 C ATOM 5234 CB GLN A 727 −31.033 25.810 −31.384 1.00 21.73 C ATOM 5235 CG GLN A 727 −31.883 26.600 −30.412 1.00 21.86 C ATOM 5236 CD GLN A 727 −33.333 26.606 −30.819 1.00 22.56 C ATOM 5237 OE1 GLN A 727 −34.196 26.169 −30.066 1.00 23.65 O ATOM 5238 NE2 GLN A 727 −33.611 27.085 −32.030 1.00 22.67 N ATOM 5239 C GLN A 727 −28.987 25.784 −29.921 1.00 22.92 C ATOM 5240 O GLN A 727 −29.370 24.782 −29.313 1.00 22.86 O ATOM 5241 N GLU A 728 −28.100 26.655 −29.425 1.00 24.59 N ATOM 5242 CA GLU A 728 −27.363 26.428 −28.164 1.00 25.62 C ATOM 5243 CB GLU A 728 −26.223 27.460 −27.991 1.00 28.61 C ATOM 5244 CG GLU A 728 −25.398 27.313 −26.702 1.00 31.97 C ATOM 5245 CD GLU A 728 −24.412 28.461 −26.458 1.00 34.77 C ATOM 5246 OE1 GLU A 728 −23.221 28.176 −26.200 1.00 36.35 O ATOM 5247 OE2 GLU A 728 −24.819 29.649 −26.504 1.00 36.57 O ATOM 5248 C GLU A 728 −28.218 26.325 −26.884 1.00 24.43 C ATOM 5249 O GLU A 728 −27.884 25.545 −26.001 1.00 24.11 O ATOM 5250 N VAL A 729 −29.303 27.094 −26.773 1.00 23.94 N ATOM 5251 CA VAL A 729 −30.138 27.030 −25.546 1.00 23.79 C ATOM 5252 CB VAL A 729 −31.088 28.246 −25.353 1.00 22.54 C ATOM 5253 CG1 VAL A 729 −30.308 29.547 −25.429 1.00 22.29 C ATOM 5254 CG2 VAL A 729 −32.240 28.232 −26.343 1.00 21.71 C ATOM 5255 C VAL A 729 −30.916 25.718 −25.445 1.00 23.93 C ATOM 5256 O VAL A 729 −31.151 25.203 −24.350 1.00 23.86 O ATOM 5257 N SER A 730 −31.286 25.174 −26.597 1.00 23.82 N ATOM 5258 CA SER A 730 −31.977 23.903 −26.658 1.00 23.48 C ATOM 5259 CB SER A 730 −32.913 23.875 −27.861 1.00 23.78 C ATOM 5260 OG SER A 730 −33.808 24.966 −27.835 1.00 24.47 O ATOM 5261 C SER A 730 −30.963 22.792 −26.782 1.00 23.19 C ATOM 5262 O SER A 730 −31.327 21.622 −26.878 1.00 23.92 O ATOM 5263 N GLN A 731 −29.689 23.172 −26.805 1.00 23.00 N ATOM 5264 CA GLN A 731 −28.572 22.236 −26.951 1.00 23.28 C ATOM 5265 CB GLN A 731 −28.208 21.644 −25.604 1.00 25.10 C ATOM 5266 CG GLN A 731 −27.274 22.521 −24.791 1.00 27.27 C ATOM 5267 CD GLN A 731 −26.589 21.733 −23.700 1.00 29.32 C ATOM 5268 OE1 GLN A 731 −27.238 20.945 −22.984 1.00 30.44 O ATOM 5269 NE2 GLN A 731 −25.263 21.906 −23.579 1.00 28.98 N ATOM 5270 C GLN A 731 −28.817 21.129 −27.970 1.00 22.34 C ATOM 5271 O GLN A 731 −28.662 19.950 −27.668 1.00 22.14 O ATOM 5272 N CYS A 732 −29.186 21.530 −29.183 1.00 21.71 N ATOM 5273 CA CYS A 732 −29.569 20.606 −30.236 1.00 20.83 C ATOM 5274 CB CYS A 732 −30.998 20.148 −30.009 1.00 22.67 C ATOM 5275 SG CYS A 732 −32.163 21.487 −30.318 1.00 26.86 S ATOM 5276 C CYS A 732 −29.498 21.316 −31.574 1.00 19.20 C ATOM 5277 O CYS A 732 −29.538 22.538 −31.626 1.00 19.48 O ATOM 5278 N PHE A 733 −29.422 20.537 −32.649 1.00 17.53 N ATOM 5279 CA PHE A 733 −29.338 21.052 −34.015 1.00 16.09 C ATOM 5280 CB PHE A 733 −28.348 20.222 −34.829 1.00 15.38 C ATOM 5281 CG PHE A 733 −26.942 20.291 −34.344 1.00 14.79 C ATOM 5282 CD1 PHE A 733 −26.080 21.271 −34.825 1.00 14.52 C ATOM 5283 CE1 PHE A 733 −24.771 21.343 −34.378 1.00 14.56 C ATOM 5284 CZ PHE A 733 −24.304 20.410 −33.464 1.00 14.64 C ATOM 5285 CE2 PHE A 733 −25.154 19.416 −32.988 1.00 14.63 C ATOM 5286 CD2 PHE A 733 −26.466 19.360 −33.428 1.00 14.59 C ATOM 5287 C PHE A 733 −30.677 20.929 −34.716 1.00 15.65 C ATOM 5288 O PHE A 733 −31.422 19.975 −34.487 1.00 15.98 O ATOM 5289 N GLY A 734 −30.966 21.877 −35.599 1.00 15.01 N ATOM 5290 CA GLY A 734 −32.084 21.734 −36.533 1.00 14.17 C ATOM 5291 C GLY A 734 −31.542 21.368 −37.895 1.00 13.34 C ATOM 5292 O GLY A 734 −30.617 22.025 −38.383 1.00 12.85 O ATOM 5293 N VAL A 735 −32.098 20.315 −38.496 1.00 13.03 N ATOM 5294 CA VAL A 735 −31.652 19.844 −39.815 1.00 13.20 C ATOM 5295 CB VAL A 735 −30.863 18.512 −39.738 1.00 13.27 C ATOM 5296 CG1 VAL A 735 −30.629 17.935 −41.129 1.00 13.13 C ATOM 5297 CG2 VAL A 735 −29.528 18.716 −39.051 1.00 13.53 C ATOM 5298 C VAL A 735 −32.807 19.667 −40.781 1.00 13.28 C ATOM 5299 O VAL A 735 −33.682 18.826 −40.559 1.00 13.28 O ATOM 5300 N LEU A 736 −32.813 20.456 −41.853 1.00 13.56 N ATOM 5301 CA LEU A 736 −33.764 20.227 −42.941 1.00 13.99 C ATOM 5302 CB LEU A 736 −33.836 21.414 −43.889 1.00 13.62 C ATOM 5303 CG LEU A 736 −34.366 22.718 −43.314 1.00 13.78 C ATOM 5304 CD1 LEU A 736 −34.606 23.702 −44.459 1.00 13.47 C ATOM 5305 CD2 LEU A 736 −35.633 22.484 −42.486 1.00 13.58 C ATOM 5306 C LEU A 736 −33.319 19.008 −43.707 1.00 14.56 C ATOM 5307 O LEU A 736 −32.151 18.899 −44.092 1.00 14.79 O ATOM 5308 N SER A 737 −34.238 18.080 −43.922 1.00 15.21 C ATOM 5309 CA SER A 737 −33.892 16.865 −44.644 1.00 15.82 C ATOM 5310 CB SER A 737 −33.429 15.774 −43.677 1.00 15.69 C ATOM 5311 OG SER A 737 −34.511 15.315 −42.892 1.00 15.93 O ATOM 5312 C SER A 737 −35.057 16.362 −45.455 1.00 16.32 C ATOM 5313 O SER A 737 −36.217 16.567 −45.080 1.00 16.42 O ATOM 5314 N SER A 738 −34.739 15.684 −46.555 1.00 16.73 N ATOM 5315 CA SER A 738 −35.757 15.102 −47.415 1.00 17.27 C ATOM 5316 CB SER A 738 −35.815 15.831 −48.768 1.00 16.85 C ATOM 5317 OG SER A 738 −34.932 15.254 −49.707 1.00 17.00 O ATOM 5318 C SER A 738 −35.527 13.601 −47.587 1.00 17.82 C ATOM 5319 O SER A 738 −34.412 13.122 −47.401 1.00 17.81 O ATOM 5320 N ARG A 739 −36.597 12.870 −47.909 1.00 18.65 N ATOM 5321 CA ARG A 739 −36.524 11.447 −48.213 1.00 19.11 C ATOM 5322 CB ARG A 739 −36.996 10.608 −47.034 1.00 19.00 C ATOM 5323 CG ARG A 739 −38.494 10.591 −46.824 1.00 19.52 C ATOM 5324 CD ARG A 739 −38.895 9.734 −45.629 1.00 19.94 C ATOM 5325 NE ARG A 739 −40.348 9.689 −45.489 1.00 20.17 N ATOM 5326 CZ ARG A 739 −41.043 10.484 −44.684 1.00 20.34 C ATOM 5327 NH1 ARG A 739 −40.424 11.371 −43.922 1.00 20.68 N ATOM 5328 NH2 ARG A 739 −42.358 10.387 −44.632 1.00 20.43 N ATOM 5329 C ARG A 739 −37.355 11.145 −49.434 1.00 20.30 C ATOM 5330 O ARG A 739 −38.263 11.898 −49.771 1.00 20.80 O ATOM 5331 N ILE A 740 −37.029 10.044 −50.103 1.00 22.13 N ATOM 5332 CA ILE A 740 −37.730 9.615 −51.311 1.00 23.03 C ATOM 5333 CB ILE A 740 −36.746 9.077 −52.362 1.00 22.78 C ATOM 5334 CG1 ILE A 740 −35.677 10.126 −52.701 1.00 22.26 C ATOM 5335 CD1 ILE A 740 −36.090 11.131 −53.746 1.00 22.28 C ATOM 5336 CG2 ILE A 740 −37.492 8.553 −53.586 1.00 22.76 C ATOM 5337 C ILE A 740 −38.708 8.497 −50.992 1.00 24.70 C ATOM 5338 O ILE A 740 −38.303 7.400 −50.582 1.00 23.66 O ATOM 5339 N GLU A 741 −39.994 8.785 −51.185 1.00 27.67 N ATOM 5340 CA GLU A 741 −41.034 7.753 −51.165 1.00 29.16 C ATOM 5341 CB GLU A 741 −42.160 8.124 −50.203 1.00 29.84 C ATOM 5342 CG GLU A 741 −41.665 8.357 −48.785 1.00 32.49 C ATOM 5343 CD GLU A 741 −42.772 8.392 −47.742 1.00 35.05 C ATOM 5344 OE1 GLU A 741 −43.949 8.634 −48.104 1.00 37.17 O ATOM 5345 OE2 GLU A 741 −42.459 8.181 −46.545 1.00 35.10 O ATOM 5346 C GLU A 741 −41.556 7.502 −52.580 1.00 29.50 C ATOM 5347 O GLU A 741 −41.397 8.330 −53.469 1.00 27.34 O ATOM 5348 N VAL A 742 −42.148 6.334 −52.779 1.00 33.40 N ATOM 5349 CA VAL A 742 −42.640 5.916 −54.091 1.00 36.20 C ATOM 5350 CB VAL A 742 −41.829 4.699 −54.619 1.00 35.91 C ATOM 5351 CG1 VAL A 742 −42.283 3.402 −53.959 1.00 35.74 C ATOM 5352 CG2 VAL A 742 −41.885 4.610 −56.142 1.00 35.57 C ATOM 5353 C VAL A 742 −44.147 5.628 −53.984 1.00 38.17 C ATOM 5354 O VAL A 742 −44.628 5.235 −52.911 1.00 39.07 O ATOM 5355 N GLN A 743 −44.880 5.843 −55.085 1.00 39.88 N ATOM 5356 CA GLN A 743 −46.365 5.842 −55.083 1.00 40.98 C ATOM 5357 CB GLN A 743 −46.921 6.345 −56.423 1.00 39.53 C ATOM 5358 C GLN A 743 −47.022 4.507 −54.732 1.00 42.56 C ATOM 5359 O GLN A 743 −46.596 3.443 −55.217 1.00 40.91 O ATOM 5360 N ASP A 744 −48.059 4.601 −53.884 1.00 44.50 N ATOM 5361 CA ASP A 744 −48.977 3.493 −53.514 1.00 45.42 C ATOM 5362 CB ASP A 744 −50.338 3.640 −54.221 1.00 42.55 C ATOM 5363 C ASP A 744 −48.417 2.087 −53.729 1.00 46.16 C ATOM 5364 O ASP A 744 −47.492 1.667 −53.032 1.00 46.48 O ATOM 5365 N THR A 749 −48.662 6.015 −50.734 1.00 41.78 N ATOM 5366 CA THR A 749 −47.269 6.491 −50.692 1.00 43.23 C ATOM 5367 CB THR A 749 −47.181 8.034 −50.764 1.00 42.51 C ATOM 5368 OG1 THR A 749 −45.810 8.426 −50.902 1.00 41.58 O ATOM 5369 CG2 THR A 749 −47.789 8.689 −49.517 1.00 42.01 C ATOM 5370 C THR A 749 −46.457 5.955 −49.489 1.00 42.37 C ATOM 5371 O THR A 749 −46.910 6.011 −48.337 1.00 43.30 O ATOM 5372 N THR A 750 −45.254 5.448 −49.770 1.00 40.16 N ATOM 5373 CA THR A 750 −44.487 4.666 −48.787 1.00 37.81 C ATOM 5374 CB THR A 750 −44.881 3.179 −48.834 1.00 37.56 C ATOM 5375 OG1 THR A 750 −44.938 2.755 −50.200 1.00 37.23 O ATOM 5376 CG2 THR A 750 −46.249 2.948 −48.172 1.00 37.47 C ATOM 5377 C THR A 750 −42.967 4.770 −48.967 1.00 35.58 C ATOM 5378 O THR A 750 −42.465 4.850 −50.087 1.00 36.98 O ATOM 5379 N ALA A 751 −42.249 4.741 −47.849 1.00 32.07 N ATOM 5380 CA ALA A 751 −40.798 4.889 −47.825 1.00 29.83 C ATOM 5381 CB ALA A 751 −40.355 5.197 −46.408 1.00 30.36 C ATOM 5382 C ALA A 751 −40.011 3.683 −48.378 1.00 28.53 C ATOM 5383 O ALA A 751 −40.531 2.568 −48.460 1.00 28.72 O ATOM 5384 N LEU A 752 −38.744 3.918 −48.730 1.00 26.56 N ATOM 5385 CA LEU A 752 −37.843 2.862 −49.230 1.00 24.67 C ATOM 5386 CB LEU A 752 −36.889 3.419 −50.292 1.00 24.64 C ATOM 5387 CG LEU A 752 −37.390 3.973 −51.626 1.00 24.30 C ATOM 5388 CD1 LEU A 752 −36.372 4.973 −52.160 1.00 24.15 C ATOM 5389 CD2 LEU A 752 −37.645 2.865 −52.636 1.00 23.77 C ATOM 5390 C LEU A 752 −37.012 2.187 −48.126 1.00 23.57 C ATOM 5391 O LEU A 752 −36.431 1.126 −48.349 1.00 23.20 O ATOM 5392 N ARG A 753 −36.937 2.817 −46.954 1.00 22.42 N ATOM 5393 CA ARG A 753 −36.257 2.247 −45.793 1.00 21.16 C ATOM 5394 CB ARG A 753 −34.762 2.062 −46.085 1.00 22.55 C ATOM 5395 CG ARG A 753 −33.865 3.256 −45.743 1.00 23.23 C ATOM 5396 CD ARG A 753 −32.699 3.397 −46.708 1.00 23.42 C ATOM 5397 NE ARG A 753 −33.139 4.030 −47.954 1.00 24.35 N ATOM 5398 CZ ARG A 753 −32.948 3.525 −49.175 1.00 24.75 C ATOM 5399 NH1 ARG A 753 −32.281 2.371 −49.346 1.00 24.18 N ATOM 5400 NH2 ARG A 753 −33.412 4.190 −50.230 1.00 24.19 N ATOM 5401 C ARG A 753 −36.457 3.159 −44.585 1.00 20.22 C ATOM 5402 O ARG A 753 −36.834 4.327 −44.744 1.00 20.29 O ATOM 5403 N PRO A 754 −36.216 2.636 −43.367 1.00 19.27 N ATOM 5404 CA PRO A 754 −36.228 3.487 −42.171 1.00 18.60 C ATOM 5405 CB PRO A 754 −35.830 2.525 −41.044 1.00 18.45 C ATOM 5406 CG PRO A 754 −35.445 1.250 −41.710 1.00 18.53 C ATOM 5407 CD PRO A 754 −36.160 1.216 −43.013 1.00 18.80 C ATOM 5408 C PRO A 754 −35.247 4.664 −42.266 1.00 17.97 C ATOM 5409 O PRO A 754 −34.109 4.493 −42.688 1.00 17.97 O ATOM 5410 N SER A 755 −35.710 5.851 −41.896 1.00 17.49 N ATOM 5411 CA SER A 755 −34.927 7.078 −42.027 1.00 17.03 C ATOM 5412 CB SER A 755 −35.615 8.052 −42.999 1.00 17.20 C ATOM 5413 OG SER A 755 −35.400 7.738 −44.364 1.00 17.53 O ATOM 5414 C SER A 755 −34.893 7.750 −40.692 1.00 16.31 C ATOM 5415 O SER A 755 −35.738 7.494 −39.859 1.00 15.90 O ATOM 5416 N ALA A 756 −33.940 8.654 −40.514 1.00 16.35 N ATOM 5417 CA ALA A 756 −33.998 9.641 −39.438 1.00 16.46 C ATOM 5418 CB ALA A 756 −33.071 10.799 −39.743 1.00 15.87 C ATOM 5419 C ALA A 756 −35.420 10.159 −39.230 1.00 16.75 C ATOM 5420 O ALA A 756 −35.957 10.082 −38.131 1.00 16.44 O ATOM 5421 N SER A 757 −36.029 10.662 −40.303 1.00 17.31 N ATOM 5422 CA SER A 757 −37.319 11.338 −40.214 1.00 17.41 C ATOM 5423 CB SER A 757 −37.544 12.234 −41.431 1.00 17.06 C ATOM 5424 OG SER A 757 −37.846 11.464 −42.589 1.00 17.43 O ATOM 5425 C SER A 757 −38.497 10.396 −40.051 1.00 18.05 C ATOM 5426 O SER A 757 −39.620 10.857 −39.901 1.00 19.13 O ATOM 5427 N THR A 758 −38.263 9.089 −40.108 1.00 18.40 N ATOM 5428 CA THR A 758 −39.346 8.125 −39.898 1.00 18.94 C ATOM 5429 CB THR A 758 −39.461 7.107 −41.062 1.00 18.59 C ATOM 5430 OG1 THR A 758 −38.284 6.292 −41.135 1.00 18.62 O ATOM 5431 CG2 THR A 758 −39.672 7.811 −42.387 1.00 18.36 C ATOM 5432 C THR A 758 −39.185 7.395 −38.552 1.00 20.10 C ATOM 5433 O THR A 758 −39.964 6.502 −38.208 1.00 19.68 O ATOM 5434 N GLN A 759 −38.165 7.801 −37.800 1.00 21.50 N ATOM 5435 CA GLN A 759 −37.742 7.102 −36.597 1.00 22.17 C ATOM 5436 CB GLN A 759 −36.492 6.275 −36.873 1.00 23.10 C ATOM 5437 CG GLN A 759 −36.631 5.154 −37.879 1.00 24.95 C ATOM 5438 CD GLN A 759 −35.324 4.378 −37.997 1.00 28.18 C ATOM 5439 OE1 GLN A 759 −34.481 4.649 −38.874 1.00 30.07 O ATOM 5440 NE2 GLN A 759 −35.121 3.435 −37.078 1.00 30.04 N ATOM 5441 C GLN A 759 −37.425 8.083 −35.472 1.00 22.05 C ATOM 5442 O GLN A 759 −36.685 7.753 −34.550 1.00 23.27 O ATOM 5443 N ALA A 760 −37.969 9.288 −35.550 1.00 21.25 N ATOM 5444 CA ALA A 760 −37.848 10.239 −34.462 1.00 20.79 C ATOM 5445 CB ALA A 760 −38.364 11.597 −34.895 1.00 20.68 C ATOM 5446 C ALA A 760 −38.643 9.738 −33.267 1.00 21.10 C ATOM 5447 O ALA A 760 −39.576 8.948 −33.421 1.00 20.50 O ATOM 5448 N LEU A 761 −38.270 10.203 −32.076 1.00 21.64 N ATOM 5449 CA LEU A 761 −39.007 9.884 −30.862 1.00 21.84 C ATOM 5450 CB LEU A 761 −38.256 10.379 −29.626 1.00 22.29 C ATOM 5451 CG LEU A 761 −37.509 9.308 −28.831 1.00 22.54 C ATOM 5452 CD1 LEU A 761 −36.212 8.880 −29.517 1.00 22.80 C ATOM 5453 CD2 LEU A 761 −37.234 9.804 −27.424 1.00 22.70 C ATOM 5454 C LEU A 761 −40.416 10.463 −30.921 1.00 22.06 C ATOM 5455 O LEU A 761 −41.390 9.715 −30.963 1.00 23.19 O ATOM 5456 N SER A 762 −40.517 11.790 −30.921 1.00 21.68 N ATOM 5457 CA SER A 762 −41.784 12.473 −31.154 1.00 21.20 C ATOM 5458 CB SER A 762 −41.960 13.641 −30.177 1.00 19.64 C ATOM 5459 C SER A 762 −41.789 12.961 −32.606 1.00 21.82 C ATOM 5460 O SER A 762 −40.725 13.288 −33.168 1.00 22.47 O ATOM 5461 N SER A 763 −42.962 12.987 −33.233 1.00 21.22 N ATOM 5462 CA SER A 763 −43.052 13.558 −34.567 1.00 21.12 C ATOM 5463 CB SER A 763 −42.814 12.493 −35.630 1.00 20.88 C ATOM 5464 OG SER A 763 −43.929 11.649 −35.754 1.00 20.83 O ATOM 5465 C SER A 763 −44.369 14.283 −34.797 1.00 21.79 C ATOM 5466 O SER A 763 −45.383 13.921 −34.228 1.00 22.49 O ATOM 5467 N SER A 764 −44.339 15.318 −35.624 1.00 22.51 N ATOM 5468 CA SER A 764 −45.536 16.074 −35.951 1.00 23.15 C ATOM 5469 CB SER A 764 −45.469 17.477 −35.349 1.00 22.96 C ATOM 5470 OG SER A 764 −44.376 18.219 −35.873 1.00 22.46 O ATOM 5471 C SER A 764 −45.704 16.161 −37.457 1.00 24.58 C ATOM 5472 O SER A 764 −44.909 15.613 −38.221 1.00 24.76 O ATOM 5473 N VAL A 765 −46.741 16.869 −37.877 1.00 26.21 N ATOM 5474 CA VAL A 765 −47.068 17.007 −39.283 1.00 27.84 C ATOM 5475 CB VAL A 765 −48.013 15.862 −39.723 1.00 27.54 C ATOM 5476 CG1 VAL A 765 −49.396 16.034 −39.109 1.00 27.88 C ATOM 5477 CG2 VAL A 765 −48.096 15.774 −41.240 1.00 28.29 C ATOM 5478 C VAL A 765 −47.704 18.389 −39.511 1.00 29.38 C ATOM 5479 O VAL A 765 −48.000 19.107 −38.547 1.00 29.42 O ATOM 5480 N SER A 766 −47.903 18.772 −40.769 1.00 30.32 N ATOM 5481 CA SER A 766 −48.663 19.984 −41.048 1.00 31.64 C ATOM 5482 CB SER A 766 −47.952 20.859 −42.078 1.00 31.06 C ATOM 5483 OG SER A 766 −46.720 21.345 −41.553 1.00 29.41 O ATOM 5484 C SER A 766 −50.118 19.685 −41.432 1.00 33.69 C ATOM 5485 O SER A 766 −51.013 20.461 −41.095 1.00 35.49 O ATOM 5486 N SER A 767 −50.351 18.557 −42.109 1.00 35.39 N ATOM 5487 CA SER A 767 −51.716 18.046 −42.387 1.00 37.19 C ATOM 5488 CB SER A 767 −52.218 17.191 −41.201 1.00 38.29 C ATOM 5489 OG SER A 767 −53.305 16.346 −41.565 1.00 39.19 O ATOM 5490 C SER A 767 −52.729 19.165 −42.743 1.00 38.06 C ATOM 5491 O SER A 767 −53.958 18.988 −42.677 1.00 38.73 O ATOM 5492 N GLU A 784 −43.142 6.228 −59.466 1.00 41.57 N ATOM 5493 CA GLU A 784 −43.087 7.684 −59.395 1.00 40.70 C ATOM 5494 CB GLU A 784 −44.464 8.301 −59.681 1.00 40.97 C ATOM 5495 C GLU A 784 −42.575 8.118 −58.022 1.00 39.92 C ATOM 5496 O GLU A 784 −43.294 8.024 −57.014 1.00 38.64 O ATOM 5497 N GLU A 785 −41.322 8.576 −57.992 1.00 37.68 N ATOM 5498 CA GLU A 785 −40.689 9.033 −56.758 1.00 35.31 C ATOM 5499 CB GLU A 785 −39.159 9.006 −56.899 1.00 35.23 C ATOM 5500 CG GLU A 785 −38.583 7.590 −56.998 1.00 37.67 C ATOM 5501 CD GLU A 785 −37.072 7.541 −57.276 1.00 40.55 C ATOM 5502 OE1 GLU A 785 −36.568 8.400 −58.037 1.00 41.73 O ATOM 5503 OE2 GLU A 785 −36.379 6.627 −56.748 1.00 39.64 O ATOM 5504 C GLU A 785 −41.215 10.421 −56.334 1.00 33.29 C ATOM 5505 O GLU A 785 −41.583 11.233 −57.166 1.00 34.08 O ATOM 5506 N VAL A 786 −41.298 10.660 −55.031 1.00 30.24 N ATOM 5507 CA VAL A 786 −41.653 11.976 −54.503 1.00 27.03 C ATOM 5508 CB VAL A 786 −43.124 12.021 −53.996 1.00 26.83 C ATOM 5509 CG1 VAL A 786 −43.351 11.030 −52.860 1.00 26.32 C ATOM 5510 CG2 VAL A 786 −43.533 13.440 −53.584 1.00 27.05 C ATOM 5511 C VAL A 786 −40.649 12.388 −53.416 1.00 24.87 C ATOM 5512 O VAL A 786 −39.833 11.585 −52.967 1.00 24.67 O ATOM 5513 N GLU A 787 −40.702 13.644 −53.016 1.00 22.84 N ATOM 5514 CA GLU A 787 −39.798 14.153 −52.020 1.00 22.20 C ATOM 5515 CB GLU A 787 −39.069 15.368 −52.574 1.00 23.80 C ATOM 5516 CG GLU A 787 −37.618 15.469 −52.175 1.00 26.07 C ATOM 5517 CD GLU A 787 −36.795 16.184 −53.227 1.00 28.70 C ATOM 5518 OE1 GLU A 787 −36.140 17.204 −52.899 1.00 30.04 O ATOM 5519 OE2 GLU A 787 −36.806 15.730 −54.396 1.00 31.22 O ATOM 5520 C GLU A 787 −40.616 14.557 −50.812 1.00 20.38 C ATOM 5521 O GLU A 787 −41.578 15.314 −50.938 1.00 20.98 O ATOM 5522 N VAL A 788 −40.250 14.043 −49.645 1.00 17.81 N ATOM 5523 CA VAL A 788 −40.904 14.439 −48.414 1.00 15.98 C ATOM 5524 CB VAL A 788 −41.475 13.234 −47.683 1.00 15.68 C ATOM 5525 CG1 VAL A 788 −42.051 13.659 −46.347 1.00 15.27 C ATOM 5526 CG2 VAL A 788 −42.528 12.568 −48.545 1.00 15.93 C ATOM 5527 C VAL A 788 −39.912 15.142 −47.516 1.00 15.20 C ATOM 5528 O VAL A 788 −38.945 14.529 −47.068 1.00 14.89 O ATOM 5529 N HIS A 789 −40.170 16.425 −47.248 1.00 14.29 N ATOM 5530 CA HIS A 789 −39.254 17.276 −46.504 1.00 13.48 C ATOM 5531 CB HIS A 789 −39.267 18.664 −47.101 1.00 13.72 C ATOM 5532 CG HIS A 789 −38.496 18.779 −48.403 1.00 14.13 C ATOM 5533 ND1 HIS A 789 −37.511 19.686 −48.588 1.00 14.27 N ATOM 5534 CE1 HIS A 789 −37.009 19.555 −49.831 1.00 14.18 C ATOM 5535 NE2 HIS A 789 −37.664 18.560 −50.443 1.00 14.11 N ATOM 5536 CD2 HIS A 789 −38.591 18.060 −49.595 1.00 14.18 C ATOM 5537 C HIS A 789 −39.589 17.327 −45.042 1.00 12.95 C ATOM 5538 O HIS A 789 −40.746 17.364 −44.672 1.00 12.67 O ATOM 5539 N ASN A 790 −38.569 17.298 −44.192 1.00 12.77 N ATOM 5540 CA ASN A 790 −38.768 17.383 −42.749 1.00 12.61 C ATOM 5541 CB ASN A 790 −38.605 16.024 −42.074 1.00 12.95 C ATOM 5542 CG ASN A 790 −39.360 14.920 −42.781 1.00 13.49 C ATOM 5543 OD1 ASN A 790 −40.445 14.499 −42.340 1.00 13.30 O ATOM 5544 ND2 ASN A 790 −38.774 14.416 −43.880 1.00 13.71 N ATOM 5545 C ASN A 790 −37.797 18.328 −42.094 1.00 12.47 C ATOM 5546 O ASN A 790 −36.745 18.646 −42.657 1.00 12.44 O ATOM 5547 N LEU A 791 −38.161 18.772 −40.892 1.00 12.35 N ATOM 5548 CA LEU A 791 −37.240 19.439 −39.973 1.00 12.01 C ATOM 5549 CB LEU A 791 −37.880 20.707 −39.379 1.00 11.42 C ATOM 5550 CG LEU A 791 −37.173 21.431 −38.225 1.00 11.03 C ATOM 5551 CD1 LEU A 791 −35.715 21.747 −38.539 1.00 11.06 C ATOM 5552 CD2 LEU A 791 −37.914 22.692 −37.855 1.00 10.65 C ATOM 5553 C LEU A 791 −36.922 18.435 −38.877 1.00 12.16 C ATOM 5554 O LEU A 791 −37.821 17.956 −38.199 1.00 12.38 O ATOM 5555 N LEU A 792 −35.652 18.098 −38.721 1.00 12.36 N ATOM 5556 CA LEU A 792 −35.253 17.174 −37.677 1.00 12.76 C ATOM 5557 CB LEU A 792 −34.156 16.242 −38.178 1.00 12.47 C ATOM 5558 CG LEU A 792 −34.416 15.483 −39.467 1.00 12.38 C ATOM 5559 CD1 LEU A 792 −33.168 14.725 −39.881 1.00 12.39 C ATOM 5560 CD2 LEU A 792 −35.603 14.551 −39.314 1.00 12.47 C ATOM 5561 C LEU A 792 −34.724 17.963 −36.506 1.00 13.33 C ATOM 5562 O LEU A 792 −34.097 19.007 −36.687 1.00 13.72 O ATOM 5563 N ILE A 793 −34.954 17.465 −35.300 1.00 13.77 N ATOM 5564 CA ILE A 793 −34.327 18.063 −34.130 1.00 14.19 C ATOM 5565 CB ILE A 793 −35.366 18.576 −33.091 1.00 13.93 C ATOM 5566 CG1 ILE A 793 −36.360 19.564 −33.729 1.00 13.75 C ATOM 5567 CD1 ILE A 793 −35.759 20.816 −34.332 1.00 13.29 C ATOM 5568 CG2 ILE A 793 −34.675 19.224 −31.908 1.00 14.24 C ATOM 5569 C ILE A 793 −33.359 17.046 −33.539 1.00 14.70 C ATOM 5570 O ILE A 793 −33.758 16.103 −32.864 1.00 15.05 O ATOM 5571 N ILE A 794 −32.081 17.230 −33.827 1.00 15.48 N ATOM 5572 CA ILE A 794 −31.060 16.288 −33.392 1.00 16.33 C ATOM 5573 CB ILE A 794 −30.045 15.999 −34.528 1.00 15.67 C ATOM 5574 CG1 ILE A 794 −30.701 15.148 −35.599 1.00 15.09 C ATOM 5575 CD1 ILE A 794 −30.330 15.595 −36.981 1.00 15.46 C ATOM 5576 CG2 ILE A 794 −28.829 15.255 −34.013 1.00 15.63 C ATOM 5577 C ILE A 794 −30.364 16.783 −32.126 1.00 17.23 C ATOM 5578 O ILE A 794 −29.845 17.893 −32.098 1.00 17.02 O ATOM 5579 N ASP A 795 −30.374 15.939 −31.090 1.00 18.72 N ATOM 5580 CA ASP A 795 −29.690 16.205 −29.816 1.00 20.14 C ATOM 5581 CB ASP A 795 −29.927 15.057 −28.835 1.00 21.72 C ATOM 5582 CG ASP A 795 −29.580 15.435 −27.402 1.00 22.75 C ATOM 5583 OD2 ASP A 795 −28.413 15.214 −26.986 1.00 22.78 O ATOM 5584 OD1 ASP A 795 −30.476 15.981 −26.711 1.00 22.89 O ATOM 5585 C ASP A 795 −28.193 16.380 −29.986 1.00 20.15 C ATOM 5586 O ASP A 795 −27.554 15.615 −30.693 1.00 20.76 O ATOM 5587 N GLN A 796 −27.629 17.364 −29.305 1.00 20.40 N ATOM 5588 CA GLN A 796 −26.246 17.748 −29.558 1.00 21.18 C ATOM 5589 CB GLN A 796 −26.052 19.217 −29.205 1.00 21.56 C ATOM 5590 CG GLN A 796 −24.810 19.571 −28.430 1.00 22.65 C ATOM 5591 CD GLN A 796 −25.107 20.620 −27.389 1.00 23.85 C ATOM 5592 OE1 GLN A 796 −25.289 20.295 −26.221 1.00 24.92 O ATOM 5593 NE2 GLN A 796 −25.196 21.886 −27.808 1.00 23.84 N ATOM 5594 C GLN A 796 −25.208 16.822 −28.898 1.00 21.38 C ATOM 5595 O GLN A 796 −24.065 16.719 −29.362 1.00 21.04 O ATOM 5596 N HIS A 797 −25.623 16.114 −27.852 1.00 21.63 N ATOM 5597 CA HIS A 797 −24.715 15.213 −27.145 1.00 21.67 C ATOM 5598 CB HIS A 797 −24.876 15.335 −25.625 1.00 22.76 C ATOM 5599 CG HIS A 797 −24.572 16.729 −25.103 1.00 24.06 C ATOM 5600 ND1 HIS A 797 −23.340 17.299 −25.215 1.00 24.32 N ATOM 5601 CE1 HIS A 797 −23.375 18.544 −24.697 1.00 24.67 C ATOM 5602 NE2 HIS A 797 −24.633 18.780 −24.255 1.00 24.64 N ATOM 5603 CD2 HIS A 797 −24.396 17.687 −24.499 1.00 24.07 C ATOM 5604 C HIS A 797 −24.829 13.805 −27.612 1.00 21.06 C ATOM 5605 O HIS A 797 −23.823 13.179 −27.894 1.00 21.65 O ATOM 5606 N THR A 798 −26.052 13.309 −27.758 1.00 20.61 N ATOM 5607 CA THR A 798 −26.269 11.910 −28.111 1.00 20.24 C ATOM 5608 CB THR A 798 −27.384 11.276 −27.262 1.00 19.85 C ATOM 5609 OG1 THR A 798 −28.650 11.839 −27.627 1.00 19.74 O ATOM 5610 CG2 THR A 798 −27.127 11.507 −25.794 1.00 20.40 C ATOM 5611 C THR A 798 −26.618 11.669 −29.574 1.00 20.39 C ATOM 5612 O THR A 798 −26.752 10.521 −29.986 1.00 21.57 O ATOM 5613 N PHE A 799 −26.796 12.740 −30.343 1.00 19.98 N ATOM 5614 CA PHE A 799 −27.235 12.654 −31.757 1.00 19.58 C ATOM 5615 CB PHE A 799 −26.067 12.332 −32.661 1.00 19.49 C ATOM 5616 CG PHE A 799 −24.960 13.311 −32.538 1.00 20.17 C ATOM 5617 CD1 PHE A 799 −25.088 14.588 −33.066 1.00 20.34 C ATOM 5618 CE1 PHE A 799 −24.059 15.506 −32.955 1.00 20.49 C ATOM 5619 CZ PHE A 799 −22.897 15.160 −32.281 1.00 20.70 C ATOM 5620 CE2 PHE A 799 −22.761 13.889 −31.738 1.00 20.84 C ATOM 5621 CD2 PHE A 799 −23.797 12.977 −31.858 1.00 20.85 C ATOM 5622 C PHE A 799 −28.463 11.784 −32.049 1.00 19.23 C ATOM 5623 O PHE A 799 −28.666 11.302 −33.170 1.00 18.58 O ATOM 5624 N GLU A 800 −29.264 11.589 −31.008 1.00 19.22 N ATOM 5625 CA GLU A 800 −30.609 11.092 −31.119 1.00 19.08 C ATOM 5626 CB GLU A 800 −31.216 11.065 −29.736 1.00 20.51 C ATOM 5627 CG GLU A 800 −31.280 9.716 −29.057 1.00 22.43 C ATOM 5628 CD GLU A 800 −32.335 9.734 −27.969 1.00 23.81 C ATOM 5629 OE1 GLU A 800 −32.151 10.502 −26.990 1.00 24.65 O ATOM 5630 OE2 GLU A 800 −33.367 9.028 −28.113 1.00 24.24 O ATOM 5631 C GLU A 800 −31.451 12.038 −31.966 1.00 18.33 C ATOM 5632 O GLU A 800 −31.307 13.275 −31.875 1.00 17.53 O ATOM 5633 N VAL A 801 −32.343 11.457 −32.769 1.00 17.31 N ATOM 5634 CA VAL A 801 −33.360 12.235 −33.488 1.00 16.37 C ATOM 5635 CB VAL A 801 −33.796 11.554 −34.799 1.00 15.84 C ATOM 5636 CG1 VAL A 801 −34.686 12.479 −35.613 1.00 15.70 C ATOM 5637 CG2 VAL A 801 −32.586 11.144 −35.607 1.00 15.73 C ATOM 5638 C VAL A 801 −34.570 12.448 −32.580 1.00 16.04 C ATOM 5639 O VAL A 801 −35.458 11.590 −32.489 1.00 15.98 O ATOM 5640 N LEU A 802 −34.590 13.598 −31.910 1.00 15.73 N ATOM 5641 CA LEU A 802 −35.589 13.891 −30.874 1.00 15.79 C ATOM 5642 CB LEU A 802 −35.133 15.067 −29.989 1.00 15.71 C ATOM 5643 CG LEU A 802 −33.882 14.829 −29.122 1.00 15.76 C ATOM 5644 CD1 LEU A 802 −33.325 16.128 −28.541 1.00 15.62 C ATOM 5645 CD2 LEU A 802 −34.136 13.777 −28.040 1.00 15.47 C ATOM 5646 C LEU A 802 −36.986 14.151 −31.430 1.00 15.66 C ATOM 5647 O LEU A 802 −37.992 13.734 −30.828 1.00 15.64 O ATOM 5648 N HIS A 803 −37.036 14.831 −32.576 1.00 15.27 N ATOM 5649 CA HIS A 803 −38.299 15.168 −33.234 1.00 15.01 C ATOM 5650 CB HIS A 803 −38.880 16.442 −32.642 1.00 14.86 C ATOM 5651 CG HIS A 803 −40.301 16.695 −33.039 1.00 14.92 C ATOM 5652 ND1 HIS A 803 −41.338 16.295 −32.292 1.00 15.04 N ATOM 5653 CE1 HIS A 803 −42.491 16.655 −32.891 1.00 14.90 C ATOM 5654 NE2 HIS A 803 −42.189 17.282 −34.025 1.00 14.99 N ATOM 5655 CD2 HIS A 803 −40.841 17.325 −34.151 1.00 15.24 C ATOM 5656 C HIS A 803 −38.175 15.315 −34.741 1.00 14.86 C ATOM 5657 O HIS A 803 −37.126 15.760 −35.273 1.00 14.43 O ATOM 5658 N ALA A 804 −39.250 14.938 −35.440 1.00 14.11 N ATOM 5659 CA ALA A 804 −39.367 15.186 −36.865 1.00 13.24 C ATOM 5660 CB ALA A 804 −39.214 13.898 −37.651 1.00 13.03 C ATOM 5661 C ALA A 804 −40.694 15.855 −37.172 1.00 12.85 C ATOM 5662 O ALA A 804 −41.745 15.311 −36.900 1.00 12.98 O ATOM 5663 N HIS A 805 −40.640 17.067 −37.695 1.00 12.59 N ATOM 5664 CA HIS A 805 −41.816 17.674 −38.279 1.00 12.55 C ATOM 5665 CB HIS A 805 −41.844 19.174 −38.002 1.00 12.52 C ATOM 5666 CG HIS A 805 −43.030 19.871 −38.602 1.00 12.48 C ATOM 5667 ND1 HIS A 805 −44.148 20.104 −37.910 1.00 12.57 N ATOM 5668 CE1 HIS A 805 −45.049 20.714 −38.707 1.00 12.63 C ATOM 5669 NE2 HIS A 805 −44.502 20.862 −39.920 1.00 12.64 N ATOM 5670 CD2 HIS A 805 −43.256 20.352 −39.893 1.00 12.56 C ATOM 5671 C HIS A 805 −41.813 17.398 −39.762 1.00 12.35 C ATOM 5672 O HIS A 805 −40.778 17.485 −40.404 1.00 12.45 O ATOM 5673 N GLN A 806 −42.965 17.050 −40.316 1.00 12.16 N ATOM 5674 CA GLN A 806 −43.064 16.782 −41.745 1.00 12.39 C ATOM 5675 CB GLN A 806 −43.680 15.408 −41.980 1.00 12.00 C ATOM 5676 CG GLN A 806 −44.019 15.127 −43.427 1.00 11.97 C ATOM 5677 CD GLN A 806 −44.332 13.671 −43.683 1.00 12.07 C ATOM 5678 OE1 GLN A 806 −43.500 12.782 −43.456 1.00 12.17 O ATOM 5679 NE2 GLN A 806 −45.521 13.417 −44.186 1.00 11.99 N ATOM 5680 C GLN A 806 −43.878 17.873 −42.452 1.00 12.92 C ATOM 5681 O GLN A 806 −45.013 18.173 −42.051 1.00 13.58 O ATOM 5682 N PHE A 807 −43.313 18.473 −43.496 1.00 12.93 N ATOM 5683 CA PHE A 807 −43.999 19.570 −44.175 1.00 13.34 C ATOM 5684 CB PHE A 807 −43.013 20.450 −44.945 1.00 13.00 C ATOM 5685 CG PHE A 807 −42.062 21.171 −44.059 1.00 12.64 C ATOM 5686 CD1 PHE A 807 −42.468 22.312 −43.375 1.00 12.49 C ATOM 5687 CE1 PHE A 807 −41.602 22.966 −42.525 1.00 12.43 C ATOM 5688 CZ PHE A 807 −40.317 22.471 −42.344 1.00 12.55 C ATOM 5689 CE2 PHE A 807 −39.905 21.327 −43.012 1.00 12.42 C ATOM 5690 CD2 PHE A 807 −40.777 20.683 −43.863 1.00 12.45 C ATOM 5691 C PHE A 807 −45.113 19.063 −45.076 1.00 14.06 C ATOM 5692 O PHE A 807 −45.314 17.849 −45.205 1.00 14.23 O ATOM 5693 N LEU A 808 −45.839 19.997 −45.685 1.00 14.58 N ATOM 5694 CA LEU A 808 −46.978 19.658 −46.527 1.00 15.34 C ATOM 5695 CB LEU A 808 −47.784 20.918 −46.856 1.00 15.73 C ATOM 5696 CG LEU A 808 −48.617 21.479 −45.685 1.00 15.84 C ATOM 5697 CD1 LEU A 808 −48.924 22.962 −45.886 1.00 15.45 C ATOM 5698 CD2 LEU A 808 −49.889 20.664 −45.469 1.00 15.32 C ATOM 5699 C LEU A 808 −46.593 18.882 −47.799 1.00 15.65 C ATOM 5700 O LEU A 808 −45.484 19.028 −48.311 1.00 15.56 O ATOM 5701 N GLN A 809 −47.507 18.027 −48.271 1.00 16.10 N ATOM 5702 CA GLN A 809 −47.302 17.277 −49.507 1.00 16.44 C ATOM 5703 CB GLN A 809 −48.590 16.539 −49.908 1.00 16.24 C ATOM 5704 C GLN A 809 −46.869 18.288 −50.568 1.00 16.78 C ATOM 5705 O GLN A 809 −47.356 19.416 −50.564 1.00 17.95 O ATOM 5706 N ASN A 810 −45.914 17.923 −51.420 1.00 16.49 N ATOM 5707 CA ASN A 810 −45.319 18.878 −52.386 1.00 16.89 C ATOM 5708 CB ASN A 810 −46.297 19.193 −53.529 1.00 16.78 C ATOM 5709 CG ASN A 810 −46.473 18.029 −54.481 1.00 17.06 C ATOM 5710 OD1 ASN A 810 −47.588 17.624 −54.754 1.00 17.08 O ATOM 5711 ND2 ASN A 810 −45.364 17.475 −54.982 1.00 17.28 N ATOM 5712 C ASN A 810 −44.689 20.190 −51.840 1.00 17.15 C ATOM 5713 O ASN A 810 −44.234 21.036 −52.624 1.00 17.44 O ATOM 5714 N GLU A 811 −44.657 20.361 −50.519 1.00 16.97 N ATOM 5715 CA GLU A 811 −43.968 21.499 −49.918 1.00 16.72 C ATOM 5716 CB GLU A 811 −44.500 21.798 −48.524 1.00 16.95 C ATOM 5717 CG GLU A 811 −43.774 22.924 −47.810 1.00 17.03 C ATOM 5718 CD GLU A 811 −44.604 23.541 −46.701 1.00 17.59 C ATOM 5719 OE1 GLU A 811 −45.160 22.775 −45.878 1.00 17.93 O ATOM 5720 OE2 GLU A 811 −44.705 24.791 −46.650 1.00 17.41 O ATOM 5721 C GLU A 811 −42.492 21.218 −49.824 1.00 16.91 C ATOM 5722 O GLU A 811 −42.065 20.242 −49.199 1.00 17.30 O ATOM 5723 N TYR A 812 −41.710 22.105 −50.417 1.00 16.96 N ATOM 5724 CA TYR A 812 −40.267 21.984 −50.451 1.00 16.43 C ATOM 5725 CB TYR A 812 −39.805 22.383 −51.834 1.00 16.95 C ATOM 5726 CG TYR A 812 −38.496 21.795 −52.249 1.00 18.12 C ATOM 5727 CD1 TYR A 812 −37.296 22.410 −51.871 1.00 18.37 C ATOM 5728 CE1 TYR A 812 −36.070 21.895 −52.268 1.00 19.11 C ATOM 5729 CZ TYR A 812 −36.026 20.734 −53.051 1.00 19.47 C ATOM 5730 OH TYR A 812 −34.771 20.249 −53.422 1.00 19.50 O ATOM 5731 CE2 TYR A 812 −37.220 20.095 −53.442 1.00 18.84 C ATOM 5732 CD2 TYR A 812 −38.441 20.630 −53.047 1.00 18.11 C ATOM 5733 C TYR A 812 −39.668 22.910 −49.416 1.00 15.57 C ATOM 5734 O TYR A 812 −40.003 24.074 −49.388 1.00 15.85 O ATOM 5735 N ALA A 813 −38.800 22.393 −48.556 1.00 15.02 N ATOM 5736 CA ALA A 813 −38.180 23.201 −47.504 1.00 14.69 C ATOM 5737 CB ALA A 813 −38.024 22.383 −46.244 1.00 14.41 C ATOM 5738 C ALA A 813 −36.825 23.685 −47.976 1.00 14.89 C ATOM 5739 O ALA A 813 −35.939 22.874 −48.208 1.00 15.70 O ATOM 5740 N LEU A 814 −36.659 24.998 −48.106 1.00 14.62 N ATOM 5741 CA LEU A 814 −35.493 25.574 −48.781 1.00 14.53 C ATOM 5742 CB LEU A 814 −35.933 26.658 −49.766 1.00 14.51 C ATOM 5743 CG LEU A 814 −36.497 26.221 −51.114 1.00 14.54 C ATOM 5744 CD1 LEU A 814 −37.030 27.432 −51.847 1.00 14.47 C ATOM 5745 CD2 LEU A 814 −35.446 25.508 −51.954 1.00 14.72 C ATOM 5746 C LEU A 814 −34.428 26.174 −47.877 1.00 14.67 C ATOM 5747 O LEU A 814 −33.241 26.092 −48.185 1.00 14.88 O ATOM 5748 N SER A 815 −34.852 26.829 −46.802 1.00 14.65 N ATOM 5749 CA SER A 815 −33.937 27.575 −45.944 1.00 14.57 C ATOM 5750 CB SER A 815 −33.940 29.054 −46.317 1.00 14.41 C ATOM 5751 OG SER A 815 −35.220 29.605 −46.144 1.00 14.08 O ATOM 5752 C SER A 815 −34.322 27.414 −44.489 1.00 14.78 C ATOM 5753 O SER A 815 −35.466 27.084 −44.178 1.00 15.03 O ATOM 5754 N LEU A 816 −33.361 27.675 −43.606 1.00 14.67 N ATOM 5755 CA LEU A 816 −33.493 27.412 −42.178 1.00 14.37 C ATOM 5756 CB LEU A 816 −33.028 25.982 −41.883 1.00 14.39 C ATOM 5757 CG LEU A 816 −32.747 25.493 −40.461 1.00 14.28 C ATOM 5758 CD1 LEU A 816 −34.025 25.206 −39.687 1.00 14.44 C ATOM 5759 CD2 LEU A 816 −31.926 24.235 −40.576 1.00 14.34 C ATOM 5760 C LEU A 816 −32.644 28.410 −41.402 1.00 14.41 C ATOM 5761 O LEU A 816 −31.620 28.883 −41.887 1.00 14.97 O ATOM 5762 N VAL A 817 −33.053 28.719 −40.187 1.00 14.25 N ATOM 5763 CA VAL A 817 −32.347 29.706 −39.390 1.00 14.51 C ATOM 5764 CB VAL A 817 −32.620 31.141 −39.924 1.00 14.25 C ATOM 5765 CG1 VAL A 817 −34.101 31.348 −40.194 1.00 14.49 C ATOM 5766 CG2 VAL A 817 −32.115 32.203 −38.976 1.00 14.20 C ATOM 5767 C VAL A 817 −32.772 29.517 −37.934 1.00 14.60 C ATOM 5768 O VAL A 817 −33.892 29.089 −37.674 1.00 14.78 O ATOM 5769 N SER A 818 −31.872 29.789 −36.995 1.00 14.77 N ATOM 5770 CA SER A 818 −32.212 29.742 −35.578 1.00 15.44 C ATOM 5771 CB SER A 818 −31.407 28.648 −34.878 1.00 15.24 C ATOM 5772 OG SER A 818 −31.482 28.754 −33.467 1.00 15.22 O ATOM 5773 C SER A 818 −31.917 31.100 −34.959 1.00 16.19 C ATOM 5774 O SER A 818 −30.803 31.600 −35.074 1.00 17.01 O ATOM 5775 N CYS A 819 −32.893 31.711 −34.304 1.00 16.69 N ATOM 5776 CA CYS A 819 −32.654 33.050 −33.783 1.00 17.57 C ATOM 5777 CB CYS A 819 −32.422 34.014 −34.945 1.00 17.85 C ATOM 5778 SG CYS A 819 −33.805 34.115 −36.108 1.00 17.92 S ATOM 5779 C CYS A 819 −33.718 33.626 −32.843 1.00 18.34 C ATOM 5780 O CYS A 819 −34.837 33.108 −32.732 1.00 18.14 O ATOM 5781 N LYS A 820 −33.317 34.695 −32.153 1.00 19.17 N ATOM 5782 CA LYS A 820 −34.207 35.557 −31.393 1.00 19.93 C ATOM 5783 CB LYS A 820 −33.437 36.229 −30.262 1.00 20.62 C ATOM 5784 CG LYS A 820 −33.155 35.361 −29.054 1.00 21.29 C ATOM 5785 CD LYS A 820 −32.085 36.027 −28.207 1.00 22.63 C ATOM 5786 CE LYS A 820 −32.441 36.008 −26.729 1.00 24.71 C ATOM 5787 NZ LYS A 820 −32.479 34.614 −26.180 1.00 27.50 N ATOM 5788 C LYS A 820 −34.688 36.642 −32.336 1.00 20.03 C ATOM 5789 O LYS A 820 −33.964 37.014 −33.266 1.00 20.25 O ATOM 5790 N LEU A 821 −35.898 37.152 −32.097 1.00 19.84 N ATOM 5791 CA LEU A 821 −36.451 38.264 −32.886 1.00 19.60 C ATOM 5792 CB LEU A 821 −37.470 37.764 −33.907 1.00 18.61 C ATOM 5793 CG LEU A 821 −36.988 36.951 −35.101 1.00 18.52 C ATOM 5794 CD1 LEU A 821 −38.167 36.412 −35.892 1.00 18.28 C ATOM 5795 CD2 LEU A 821 −36.075 37.781 −35.995 1.00 18.80 C ATOM 5796 C LEU A 821 −37.114 39.296 −31.993 1.00 20.43 C ATOM 5797 O LEU A 821 −37.744 38.955 −30.984 1.00 21.13 O ATOM 5798 N GLY A 822 −36.979 40.560 −32.365 1.00 20.99 N ATOM 5799 CA GLY A 822 −37.623 41.637 −31.626 1.00 21.94 C ATOM 5800 C GLY A 822 −37.318 41.580 −30.146 1.00 22.32 C ATOM 5801 O GLY A 822 −36.158 41.482 −29.753 1.00 22.59 O ATOM 5802 N LYS A 823 −38.373 41.617 −29.338 1.00 22.96 N ATOM 5803 CA LYS A 823 −38.271 41.652 −27.881 1.00 23.50 C ATOM 5804 CB LYS A 823 −39.138 42.788 −27.337 1.00 24.39 C ATOM 5805 CG LYS A 823 −38.675 44.169 −27.760 1.00 25.56 C ATOM 5806 CD LYS A 823 −39.602 45.259 −27.251 1.00 26.76 C ATOM 5807 CE LYS A 823 −38.924 46.619 −27.366 1.00 28.25 C ATOM 5808 NZ LYS A 823 −39.875 47.703 −27.751 1.00 28.96 N ATOM 5809 C LYS A 823 −38.689 40.324 −27.238 1.00 23.70 C ATOM 5810 O LYS A 823 −39.034 40.277 −26.058 1.00 24.02 O ATOM 5811 N ASP A 824 −38.646 39.253 −28.022 1.00 23.38 N ATOM 5812 CA ASP A 824 −39.113 37.942 −27.599 1.00 22.56 C ATOM 5813 CB ASP A 824 −39.669 37.211 −28.822 1.00 23.15 C ATOM 5814 OG ASP A 824 −40.546 36.023 −28.466 1.00 23.23 C ATOM 5815 OD1 ASP A 824 −40.192 35.234 −27.549 1.00 23.21 O ATOM 5816 OD2 ASP A 824 −41.584 35.863 −29.148 1.00 22.57 O ATOM 5817 C ASP A 824 −37.924 37.180 −27.048 1.00 22.46 C ATOM 5818 O ASP A 824 −36.919 37.025 −27.753 1.00 22.85 O ATOM 5819 N PRO A 825 −38.022 36.690 −25.791 1.00 22.18 N ATOM 5820 CA PRO A 825 −36.864 36.016 −25.190 1.00 22.07 C ATOM 5821 CB PRO A 825 −37.272 35.867 −23.716 1.00 21.00 C ATOM 5822 CG PRO A 825 −38.751 35.806 −23.743 1.00 20.92 C ATOM 5823 CD PRO A 825 −39.181 36.700 −24.877 1.00 21.85 C ATOM 5824 C PRO A 825 −36.546 34.647 −25.830 1.00 22.24 C ATOM 5825 O PRO A 825 −35.424 34.147 −25.692 1.00 22.46 O ATOM 5826 N ASN A 826 −37.515 34.066 −26.533 1.00 22.21 N ATOM 5827 CA ASN A 826 −37.352 32.738 −27.120 1.00 22.84 C ATOM 5828 CB ASN A 826 −38.692 32.222 −27.637 1.00 23.71 C ATOM 5829 CG ASN A 826 −39.740 32.098 −26.548 1.00 24.28 C ATOM 5830 OD1 ASN A 826 −39.537 32.525 −25.409 1.00 24.42 O ATOM 5831 ND2 ASN A 826 −40.878 31.504 −26.902 1.00 24.56 N ATOM 5832 C ASN A 826 −36.356 32.684 −28.263 1.00 22.55 C ATOM 5833 O ASN A 826 −36.101 33.685 −28.926 1.00 23.50 O ATOM 5834 N THR A 827 −35.791 31.506 −28.488 1.00 22.30 N ATOM 5835 CA THR A 827 −35.084 31.227 −29.737 1.00 21.97 C ATOM 5836 CB THR A 827 −33.686 30.586 −29.515 1.00 22.06 C ATOM 5837 OG1 THR A 827 −32.882 31.446 −28.700 1.00 23.06 O ATOM 5838 CG2 THR A 827 −32.959 30.391 −30.837 1.00 21.38 C ATOM 5839 C THR A 827 −35.962 30.307 −30.572 1.00 21.02 C ATOM 5840 O THR A 827 −36.590 29.381 −30.048 1.00 20.90 O ATOM 5841 N TYR A 828 −36.002 30.569 −31.871 1.00 19.72 N ATOM 5842 CA TYR A 828 −36.860 29.826 −32.759 1.00 18.62 C ATOM 5843 CB TYR A 828 −37.883 30.773 −33.359 1.00 19.31 C ATOM 5844 CG TYR A 828 −38.772 31.434 −32.343 1.00 19.91 C ATOM 5845 CD1 TYR A 828 −39.820 30.733 −31.746 1.00 20.68 C ATOM 5846 CE1 TYR A 828 −40.648 31.333 −30.813 1.00 21.11 C ATOM 5847 CZ TYR A 828 −40.439 32.653 −30.475 1.00 21.38 C ATOM 5848 OH TYR A 828 −41.265 33.250 −29.560 1.00 22.22 O ATOM 5849 CE2 TYR A 828 −39.409 33.373 −31.056 1.00 21.26 C ATOM 5850 CD2 TYR A 828 −38.583 32.757 −31.987 1.00 20.43 C ATOM 5851 C TYR A 828 −36.081 29.168 −33.874 1.00 17.53 C ATOM 5852 O TYR A 828 −35.023 29.663 −34.270 1.00 17.29 O ATOM 5853 N PHE A 829 −36.599 28.044 −34.370 1.00 16.29 N ATOM 5854 CA PHE A 829 −36.197 27.529 −35.676 1.00 15.10 C ATOM 5855 CB PHE A 829 −36.248 26.008 −35.735 1.00 14.95 C ATOM 5856 CG PHE A 829 −35.180 25.339 −34.931 1.00 15.22 C ATOM 5857 CD1 PHE A 829 −33.854 25.343 −35.367 1.00 15.37 C ATOM 5858 CE1 PHE A 829 −32.862 24.730 −34.618 1.00 15.26 C ATOM 5859 CZ PHE A 829 −33.195 24.101 −33.421 1.00 15.48 C ATOM 5860 CE2 PHE A 829 −34.506 24.089 −32.979 1.00 15.16 C ATOM 5861 CD2 PHE A 829 −35.489 24.707 −33.730 1.00 15.11 C ATOM 5862 C PHE A 829 −37.177 28.102 −36.647 1.00 14.47 C ATOM 5863 O PHE A 829 −38.369 28.156 −36.360 1.00 14.47 O ATOM 5864 N ILE A 830 −36.675 28.548 −37.788 1.00 14.04 N ATOM 5865 CA ILE A 830 −37.483 29.277 −38.758 1.00 13.93 C ATOM 5866 CB ILE A 830 −37.158 30.795 −38.698 1.00 13.78 C ATOM 5867 CG1 ILE A 830 −37.472 31.360 −37.312 1.00 13.54 C ATOM 5868 CD1 ILE A 830 −37.182 32.832 −37.176 1.00 13.54 C ATOM 5869 CG2 ILE A 830 −37.924 31.566 −39.757 1.00 13.74 C ATOM 5870 C ILE A 830 −37.222 28.719 −40.161 1.00 13.85 C ATOM 5871 O ILE A 830 −36.129 28.877 −40.688 1.00 14.49 O ATOM 5872 N VAL A 831 −38.213 28.059 −40.759 1.00 13.48 N ATOM 5873 CA VAL A 831 −38.019 27.401 −42.062 1.00 13.13 C ATOM 5874 CB VAL A 831 −38.638 25.986 −42.111 1.00 13.02 C ATOM 5875 CG1 VAL A 831 −38.430 25.350 −43.482 1.00 12.54 C ATOM 5876 CG2 VAL A 831 −38.068 25.100 −41.007 1.00 13.06 C ATOM 5877 C VAL A 831 −38.648 28.194 −43.172 1.00 13.15 C ATOM 5878 O VAL A 831 −39.764 28.691 −43.018 1.00 13.30 O ATOM 5879 N GLY A 832 −37.944 28.282 −44.299 1.00 13.17 N ATOM 5880 CA GLY A 832 −38.483 28.889 −45.515 1.00 13.30 C ATOM 5881 C GLY A 832 −38.822 27.815 −46.525 1.00 13.27 C ATOM 5882 O GLY A 832 −37.974 27.018 −46.876 1.00 13.41 O ATOM 5883 N THR A 833 −40.068 27.780 −46.985 1.00 13.41 N ATOM 5884 CA THR A 833 −40.509 26.721 −47.895 1.00 13.64 C ATOM 5885 CB THR A 833 −41.745 25.993 −47.359 1.00 13.53 C ATOM 5886 OG1 THR A 833 −42.902 26.799 −47.608 1.00 13.58 O ATOM 5887 CG2 THR A 833 −41.610 25.693 −45.872 1.00 13.26 C ATOM 5888 C THR A 833 −40.892 27.275 −49.252 1.00 13.89 C ATOM 5889 O THR A 833 −40.839 28.483 −49.457 1.00 14.34 O ATOM 5890 N ALA A 834 −41.282 26.388 −50.169 1.00 13.92 N ATOM 5891 CA ALA A 834 −41.874 26.774 −51.447 1.00 14.49 C ATOM 5892 CB ALA A 834 −40.811 27.031 −52.480 1.00 14.65 C ATOM 5893 C ALA A 834 −42.741 25.652 −51.903 1.00 15.22 C ATOM 5894 O ALA A 834 −42.435 24.508 −51.643 1.00 15.69 O ATOM 5895 N MET A 835 −43.838 25.978 −52.571 1.00 16.65 N ATOM 5896 CA MET A 835 −44.747 24.969 −53.094 1.00 17.69 C ATOM 5897 CB MET A 835 −46.174 25.497 −53.132 1.00 18.63 C ATOM 5898 CG MET A 835 −46.883 25.416 −51.804 1.00 19.98 C ATOM 5899 SD MET A 835 −47.081 23.720 −51.208 1.00 22.02 S ATOM 5900 CE MET A 835 −46.739 24.064 −49.486 1.00 20.65 C ATOM 5901 C MET A 835 −44.318 24.579 −54.490 1.00 18.17 C ATOM 5902 O MET A 835 −44.325 25.415 −55.402 1.00 18.56 O ATOM 5903 N VAL A 836 −43.965 23.312 −54.661 1.00 18.27 N ATOM 5904 CA VAL A 836 −43.425 22.858 −55.925 1.00 19.17 C ATOM 5905 CB VAL A 836 −42.120 22.091 −55.726 1.00 18.73 C ATOM 5906 CG1 VAL A 836 −41.572 21.626 −57.064 1.00 18.56 C ATOM 5907 CG2 VAL A 836 −41.116 22.973 −55.013 1.00 18.31 C ATOM 5908 C VAL A 836 −44.399 21.988 −56.683 1.00 20.28 C ATOM 5909 O VAL A 836 −44.726 20.892 −56.244 1.00 20.81 O ATOM 5910 N TYR A 837 −44.854 22.479 −57.828 1.00 21.89 N ATOM 5911 CA TYR A 837 −45.688 21.681 −58.714 1.00 23.55 C ATOM 5912 CB TYR A 837 −47.029 22.366 −58.967 1.00 23.66 C ATOM 5913 CG TYR A 837 −47.863 22.472 −57.715 1.00 23.82 C ATOM 5914 CD1 TYR A 837 −48.475 21.349 −57.169 1.00 23.68 C ATOM 5915 CE1 TYR A 837 −49.224 21.431 −56.012 1.00 23.88 C ATOM 5916 CZ TYR A 837 −49.371 22.646 −55.384 1.00 24.81 C ATOM 5917 OH TYR A 837 −50.124 22.735 −54.230 1.00 26.02 O ATOM 5918 CE2 TYR A 837 −48.772 23.782 −55.907 1.00 25.07 C ATOM 5919 CD2 TYR A 837 −48.019 23.688 −57.064 1.00 24.32 C ATOM 5920 C TYR A 837 −44.965 21.409 −60.013 1.00 25.06 C ATOM 5921 O TYR A 837 −44.210 22.252 −60.483 1.00 26.00 O ATOM 5922 N PRO A 838 −45.170 20.212 −60.583 1.00 26.38 N ATOM 5923 CA PRO A 838 −44.587 19.839 −61.879 1.00 28.36 C ATOM 5924 CB PRO A 838 −44.995 18.371 −62.030 1.00 27.95 C ATOM 5925 CG PRO A 838 −45.241 17.901 −60.635 1.00 26.88 C ATOM 5926 CD PRO A 838 −45.836 19.073 −59.934 1.00 26.11 C ATOM 5927 C PRO A 838 −45.118 20.667 −63.068 1.00 30.43 C ATOM 5928 O PRO A 838 −44.360 20.989 −63.980 1.00 29.96 O ATOM 5929 N GLU A 839 −46.404 21.005 −63.049 1.00 34.21 N ATOM 5930 CA GLU A 839 −47.031 21.775 −64.129 1.00 37.52 C ATOM 5931 CB GLU A 839 −48.563 21.694 −64.039 1.00 40.23 C ATOM 5932 CG GLU A 839 −49.118 20.308 −63.714 1.00 42.52 C ATOM 5933 CD GLU A 839 −49.312 20.089 −62.219 1.00 43.36 C ATOM 5934 OE1 GLU A 839 −48.412 20.464 −61.431 1.00 41.74 O ATOM 5935 OE2 GLU A 839 −50.372 19.543 −61.830 1.00 44.58 O ATOM 5936 C GLU A 839 −46.605 23.238 −64.086 1.00 38.03 C ATOM 5937 O GLU A 839 −46.546 23.915 −65.110 1.00 39.38 O ATOM 5938 N GLU A 840 −46.313 23.717 −62.889 1.00 38.16 N ATOM 5939 CA GLU A 840 −45.997 25.103 −62.674 1.00 38.37 C ATOM 5940 CB GLU A 840 −46.708 25.571 −61.395 1.00 44.04 C ATOM 5941 CG GLU A 840 −46.404 26.982 −60.913 1.00 50.48 C ATOM 5942 CD GLU A 840 −46.446 27.099 −59.388 1.00 55.97 C ATOM 5943 OE1 GLU A 840 −45.631 26.428 −58.705 1.00 58.23 O ATOM 5944 OE2 GLU A 840 −47.287 27.869 −58.867 1.00 58.66 O ATOM 5945 C GLU A 840 −44.476 25.231 −62.579 1.00 36.02 C ATOM 5946 O GLU A 840 −43.867 24.741 −61.635 1.00 35.67 O ATOM 5947 N ALA A 841 −43.872 25.873 −63.578 1.00 33.36 N ATOM 5948 CA ALA A 841 −42.428 26.106 −63.610 1.00 31.35 C ATOM 5949 CB ALA A 841 −42.009 26.645 −64.965 1.00 30.55 C ATOM 5950 C ALA A 841 −41.937 27.037 −62.507 1.00 31.54 C ATOM 5951 O ALA A 841 −40.943 26.737 −61.847 1.00 31.65 O ATOM 5952 N GLU A 842 −42.627 28.164 −62.320 1.00 31.70 N ATOM 5953 CA GLU A 842 −42.178 29.221 −61.403 1.00 31.94 C ATOM 5954 CB GLU A 842 −42.353 30.591 −62.049 1.00 35.00 C ATOM 5955 CG GLU A 842 −41.577 30.765 −63.335 1.00 39.59 C ATOM 5956 CD GLU A 842 −40.954 32.140 −63.456 1.00 42.67 C ATOM 5957 OE1 GLU A 842 −41.697 33.092 −63.792 1.00 44.57 O ATOM 5958 OE2 GLU A 842 −39.722 32.262 −63.220 1.00 43.98 O ATOM 5959 C GLU A 842 −42.921 29.206 −60.075 1.00 30.30 C ATOM 5960 O GLU A 842 −44.147 29.241 −60.058 1.00 31.43 O ATOM 5961 N PRO A 843 −42.184 29.182 −58.952 1.00 28.49 N ATOM 5962 CA PRO A 843 −42.830 29.129 −57.640 1.00 27.77 C ATOM 5963 CB PRO A 843 −41.649 29.087 −56.665 1.00 26.96 C ATOM 5964 CG PRO A 843 −40.497 29.653 −57.422 1.00 26.55 C ATOM 5965 CD PRO A 843 −40.717 29.241 −58.842 1.00 27.88 C ATOM 5966 C PRO A 843 −43.739 30.345 −57.373 1.00 27.58 C ATOM 5967 O PRO A 843 −43.303 31.499 −57.504 1.00 27.11 O ATOM 5968 N LYS A 844 −44.997 30.072 −57.020 1.00 27.44 N ATOM 5969 CA LYS A 844 −46.002 31.123 −56.804 1.00 25.89 C ATOM 5970 CB LYS A 844 −47.177 30.980 −57.785 1.00 26.93 C ATOM 5971 CG LYS A 844 −46.845 31.287 −59.242 1.00 29.52 C ATOM 5972 CD LYS A 844 −46.272 32.700 −59.437 1.00 32.04 C ATOM 5973 CE LYS A 844 −46.153 33.091 −60.915 1.00 32.36 C ATOM 5974 NZ LYS A 844 −47.488 33.250 −61.580 1.00 32.31 N ATOM 5975 C LYS A 844 −46.524 31.182 −55.368 1.00 24.20 C ATOM 5976 O LYS A 844 −47.281 32.087 −55.031 1.00 24.21 O ATOM 5977 N GLN A 845 −46.127 30.225 −54.529 1.00 22.46 N ATOM 5978 CA GLN A 845 −46.493 30.258 −53.109 1.00 21.27 C ATOM 5979 CB GLN A 845 −47.929 29.778 −52.882 1.00 22.22 C ATOM 5980 CG GLN A 845 −48.238 28.472 −53.566 1.00 24.19 C ATOM 5981 CD GLN A 845 −49.571 27.885 −53.162 1.00 26.04 C ATOM 5982 OE1 GLN A 845 −49.937 27.876 −51.975 1.00 27.58 O ATOM 5983 NE2 GLN A 845 −50.302 27.357 −54.147 1.00 26.79 N ATOM 5984 C GLN A 845 −45.518 29.511 −52.202 1.00 19.73 C ATOM 5985 O GLN A 845 −44.909 28.533 −52.608 1.00 19.32 O ATOM 5986 N GLY A 846 −45.381 29.998 −50.972 1.00 18.27 N ATOM 5987 CA GLY A 846 −44.487 29.417 −49.995 1.00 17.03 C ATOM 5988 C GLY A 846 −44.770 29.955 −48.606 1.00 16.57 C ATOM 5989 O GLY A 846 −45.492 30.941 −48.445 1.00 16.36 O ATOM 5990 N ARG A 847 −44.195 29.298 −47.601 1.00 15.75 N ATOM 5991 CA ARG A 847 −44.403 29.670 −46.208 1.00 15.15 C ATOM 5992 CB ARG A 847 −44.888 28.472 −45.402 1.00 15.30 C ATOM 5993 CG ARG A 847 −46.331 28.094 −45.607 1.00 15.89 C ATOM 5994 CD ARG A 847 −46.815 27.273 −44.424 1.00 16.02 C ATOM 5995 NE ARG A 847 −46.301 25.912 −44.454 1.00 15.95 N ATOM 5996 CZ ARG A 847 −46.400 25.056 −43.448 1.00 15.83 C ATOM 5997 NH1 ARG A 847 −46.979 25.419 −42.313 1.00 15.80 N ATOM 5998 NH2 ARG A 847 −45.901 23.838 −43.572 1.00 15.99 N ATOM 5999 C ARG A 847 −43.112 30.112 −45.564 1.00 14.66 C ATOM 6000 O ARG A 847 −42.023 29.737 −46.006 1.00 14.62 O ATOM 6001 N ILE A 848 −43.250 30.902 −44.505 1.00 14.02 N ATOM 6002 CA ILE A 848 −42.232 31.018 −43.479 1.00 13.33 C ATOM 6003 CB ILE A 848 −41.739 32.464 −43.311 1.00 12.75 C ATOM 6004 CG1 ILE A 848 −41.166 32.967 −44.635 1.00 12.39 C ATOM 6005 CD1 ILE A 848 −40.986 34.458 −44.690 1.00 12.60 C ATOM 6006 CG2 ILE A 848 −40.702 32.559 −42.202 1.00 12.28 C ATOM 6007 C ILE A 848 −42.897 30.501 −42.221 1.00 13.32 C ATOM 6008 O ILE A 848 −43.954 30.994 −41.831 1.00 13.34 O ATOM 6009 N VAL A 849 −42.310 29.461 −41.639 1.00 13.55 N ATOM 6010 CA VAL A 849 −42.873 28.803 −40.464 1.00 13.94 C ATOM 6011 CB VAL A 849 −42.991 27.266 −40.636 1.00 13.95 C ATOM 6012 CG1 VAL A 849 −43.987 26.706 −39.644 1.00 14.14 C ATOM 6013 CG2 VAL A 849 −43.428 26.887 −42.034 1.00 14.08 C ATOM 6014 C VAL A 849 −41.959 29.064 −39.284 1.00 14.24 C ATOM 6015 O VAL A 849 −40.746 28.880 −39.385 1.00 14.53 O ATOM 6016 N VAL A 850 −42.531 29.478 −38.162 1.00 14.52 N ATOM 6017 CA VAL A 850 −41.725 29.729 −36.974 1.00 15.00 C ATOM 6018 CB VAL A 850 −41.944 31.148 −36.401 1.00 14.87 C ATOM 6019 CG1 VAL A 850 −41.060 31.362 −35.182 1.00 14.82 C ATOM 6020 CG2 VAL A 850 −41.681 32.214 −37.465 1.00 14.43 C ATOM 6021 C VAL A 850 −42.025 28.669 −35.930 1.00 15.50 C ATOM 6022 O VAL A 850 −43.137 28.596 −35.400 1.00 15.93 O ATOM 6023 N PHE A 851 −41.033 27.828 −35.660 1.00 15.88 N ATOM 6024 CA PHE A 851 −41.196 26.720 −34.732 1.00 16.16 C ATOM 6025 CB PHE A 851 −40.574 25.449 −35.294 1.00 15.51 C ATOM 6026 CG PHE A 851 −41.290 24.872 −36.472 1.00 14.84 C ATOM 6027 CD1 PHE A 851 −42.495 24.230 −36.317 1.00 14.75 C ATOM 6028 CE1 PHE A 851 −43.140 23.674 −37.401 1.00 14.91 C ATOM 6029 CZ PHE A 851 −42.563 23.734 −38.656 1.00 14.81 C ATOM 6030 CE2 PHE A 851 −41.353 24.371 −38.821 1.00 14.80 C ATOM 6031 CD2 PHE A 851 −40.721 24.926 −37.728 1.00 14.72 C ATOM 6032 C PHE A 851 −40.476 27.035 −33.446 1.00 17.05 C ATOM 6033 O PHE A 851 −39.466 27.750 −33.450 1.00 17.12 O ATOM 6034 N GLN A 852 −40.971 26.468 −32.351 1.00 18.36 N ATOM 6035 CA GLN A 852 −40.227 26.480 −31.099 1.00 19.72 C ATOM 6036 CB GLN A 852 −40.814 27.485 −30.122 1.00 19.96 C ATOM 6037 CG GLN A 852 −39.873 27.770 −28.967 1.00 20.21 C ATOM 6038 CD GLN A 852 −40.597 28.126 −27.689 1.00 20.57 C ATOM 6039 OE1 GLN A 852 −41.767 28.553 −27.700 1.00 20.03 O ATOM 6040 NE2 GLN A 852 −39.902 27.958 −26.568 1.00 20.70 N ATOM 6041 C GLN A 852 −40.109 25.107 −30.439 1.00 20.20 C ATOM 6042 O GLN A 852 −41.099 24.394 −30.266 1.00 19.60 O ATOM 6043 N TYR A 853 −38.877 24.760 −30.081 1.00 21.60 N ATOM 6044 CA TYR A 853 −38.570 23.497 −29.430 1.00 23.71 C ATOM 6045 CB TYR A 853 −37.305 22.859 −30.025 1.00 23.98 C ATOM 6046 CG TYR A 853 −36.928 21.536 −29.393 1.00 24.62 C ATOM 6047 CD1 TYR A 853 −37.569 20.345 −29.763 1.00 24.78 C ATOM 6048 CE1 TYR A 853 −37.233 19.137 −29.178 1.00 24.28 C ATOM 6049 CZ TYR A 853 −36.239 19.107 −28.211 1.00 25.55 C ATOM 6050 OH TYR A 853 −35.876 17.919 −27.602 1.00 26.22 O ATOM 6051 CE2 TYR A 853 −35.591 20.272 −27.833 1.00 25.72 C ATOM 6052 CD2 TYR A 853 −35.937 21.473 −28.422 1.00 25.11 C ATOM 6053 C TYR A 853 −38.444 23.672 −27.914 1.00 25.55 C ATOM 6054 O TYR A 853 −37.380 24.040 −27.375 1.00 25.10 O ATOM 6055 N SER A 854 −39.562 23.422 −27.245 1.00 27.82 N ATOM 6056 CA SER A 854 −39.627 23.377 −25.797 1.00 29.56 C ATOM 6057 CB SER A 854 −40.540 24.480 −25.286 1.00 30.67 C ATOM 6058 OG SER A 854 −41.754 24.481 −26.017 1.00 32.24 O ATOM 6059 C SER A 854 −40.161 22.008 −25.369 1.00 31.09 C ATOM 6060 O SER A 854 −40.861 21.321 −26.146 1.00 29.93 O ATOM 6061 N ASP A 855 −39.842 21.629 −24.128 1.00 32.11 N ATOM 6062 CA ASP A 855 −40.039 20.262 −23.652 1.00 32.05 C ATOM 6063 CB ASP A 855 −41.536 19.946 −23.449 1.00 31.95 C ATOM 6064 C ASP A 855 −39.383 19.294 −24.649 1.00 31.91 C ATOM 6065 O ASP A 855 −38.193 19.428 −24.975 1.00 30.70 O ATOM 6066 N GLY A 856 −40.160 18.338 −25.141 1.00 31.56 N ATOM 6067 CA GLY A 856 −39.661 17.405 −26.129 1.00 31.97 C ATOM 6068 C GLY A 856 −40.421 17.623 −27.407 1.00 31.90 C ATOM 6069 O GLY A 856 −40.420 16.778 −28.302 1.00 32.02 O ATOM 6070 N LYS A 857 −41.075 18.772 −27.496 1.00 32.14 N ATOM 6071 CA LYS A 857 −41.992 19.009 −28.602 1.00 31.89 C ATOM 6072 CB LYS A 857 −43.454 19.082 −28.096 1.00 31.97 C ATOM 6073 C LYS A 857 −41.633 20.218 −29.484 1.00 29.52 C ATOM 6074 O LYS A 857 −41.096 21.231 −29.018 1.00 27.92 O ATOM 6075 N LEU A 858 −41.926 20.070 −30.767 1.00 27.13 N ATOM 6076 CA LEU A 858 −41.909 21.164 −31.686 1.00 26.97 C ATOM 6077 CB LEU A 858 −41.410 20.672 −33.034 1.00 25.10 C ATOM 6078 CG LEU A 858 −40.520 21.599 −33.854 1.00 24.17 C ATOM 6079 CD1 LEU A 858 −39.439 22.260 −33.009 1.00 23.42 C ATOM 6080 CD2 LEU A 858 −39.894 20.782 −34.967 1.00 24.01 C ATOM 6081 C LEU A 858 −43.328 21.730 −31.811 1.00 28.62 C ATOM 6082 O LEU A 858 −44.271 21.002 −32.161 1.00 30.00 O ATOM 6083 N GLN A 859 −43.475 23.020 −31.499 1.00 28.52 N ATOM 6084 CA GLN A 859 −44.747 23.740 −31.657 1.00 27.23 C ATOM 6085 CB GLN A 859 −45.042 24.594 −30.411 1.00 29.33 C ATOM 6086 CG GLN A 859 −45.044 23.844 −29.084 1.00 31.42 C ATOM 6087 CD GLN A 859 −46.309 23.026 −28.872 1.00 33.73 C ATOM 6088 OE1 GLN A 859 −46.257 21.794 −28.764 1.00 35.00 O ATOM 6089 NE2 GLN A 859 −47.458 23.707 −28.820 1.00 34.00 N ATOM 6090 C GLN A 859 −44.654 24.661 −32.868 1.00 25.15 C ATOM 6091 O GLN A 859 −43.581 25.193 −33.152 1.00 25.81 O ATOM 6092 N THR A 860 −45.764 24.858 −33.582 1.00 22.39 N ATOM 6093 CA THR A 860 −45.809 25.892 −34.619 1.00 19.82 C ATOM 6094 CB THR A 860 −46.701 25.516 −35.814 1.00 19.12 C ATOM 6095 OG1 THR A 860 −46.196 24.326 −34.427 1.00 19.32 O ATOM 6096 CG2 THR A 860 −46.694 26.626 −36.851 1.00 18.62 C ATOM 6097 C THR A 860 −46.283 27.189 −33.998 1.00 18.91 C ATOM 6098 O THR A 860 −47.459 27.329 −33.631 1.00 19.01 O ATOM 6099 N VAL A 861 −45.360 28.136 −33.871 1.00 17.46 N ATOM 6100 CA VAL A 861 −45.664 29.403 −33.235 1.00 16.79 C ATOM 6101 CB VAL A 861 −44.439 29.972 −32.487 1.00 16.93 C ATOM 6102 CG1 VAL A 861 −44.720 31.373 −31.976 1.00 17.32 C ATOM 6103 CG2 VAL A 861 −44.043 29.065 −31.330 1.00 16.70 C ATOM 6104 C VAL A 861 −46.250 30.425 −34.208 1.00 16.48 C ATOM 6105 O VAL A 861 −47.020 31.274 −33.798 1.00 16.64 O ATOM 6106 N ALA A 862 −45.894 30.345 −35.492 1.00 16.59 N ATOM 6107 CA ALA A 862 −46.434 31.266 −36.508 1.00 16.55 C ATOM 6108 CB ALA A 862 −45.920 32.687 −36.279 1.00 16.32 C ATOM 6109 C ALA A 862 −46.166 30.833 −37.952 1.00 16.68 C ATOM 6110 O ALA A 862 −45.181 30.168 −38.236 1.00 16.40 O ATOM 6111 N ALA A 862 −47.064 31.230 −38.848 1.00 17.56 N ATOM 6112 CA ALA A 862 −46.902 31.072 −40.283 1.00 18.51 C ATOM 6113 CB ALA A 862 −48.113 30.354 −40.857 1.00 19.75 C ATOM 6114 CG ALA A 862 −48.079 28.842 −40.792 1.00 21.83 C ATOM 6115 CD ALA A 862 −49.250 28.213 −41.540 1.00 23.51 C ATOM 6116 OE1 ALA A 862 −48.992 27.346 −42.415 1.00 24.07 O ATOM 6117 OE2 ALA A 862 −50.424 28.597 −41.271 1.00 23.91 O ATOM 6118 C ALA A 862 −46.851 32.447 −40.944 1.00 19.06 C ATOM 6119 O GLU A 863 −47.348 33.435 −40.383 1.00 19.83 O ATOM 6120 N LYS A 864 −46.278 32.510 −42.145 1.00 18.69 N ATOM 6121 CA LYS A 864 −46.487 33.654 −43.048 1.00 18.78 C ATOM 6122 CB LYS A 864 −45.409 34.732 −42.856 1.00 18.55 C ATOM 6123 CG LYS A 864 −45.952 36.081 −42.416 1.00 18.28 C ATOM 6124 CD LYS A 864 −46.052 37.043 −43.591 1.00 18.14 C ATOM 6125 CE LYS A 864 −47.168 38.065 −43.430 1.00 18.12 C ATOM 6126 NZ LYS A 864 −47.546 38.323 −42.015 1.00 18.59 N ATOM 6127 C LYS A 864 −46.514 33.174 −44.490 1.00 18.80 C ATOM 6128 O LYS A 864 −45.516 32.653 −44.991 1.00 19.34 O ATOM 6129 N GLU A 865 −47.660 33.300 −45.153 1.00 18.25 N ATOM 6130 CA GLU A 865 −47.719 32.898 −46.549 1.00 17.72 C ATOM 6131 CB GLU A 865 −49.124 32.479 −46.977 1.00 18.02 C ATOM 6132 CG GLU A 865 −49.443 31.036 −46.570 1.00 18.92 C ATOM 6133 CD GLU A 865 −49.220 29.979 −47.678 1.00 19.66 C ATOM 6134 OE1 GLU A 865 −49.230 28.761 −47.339 1.00 19.80 O ATOM 6135 OE2 GLU A 865 −49.057 30.339 −48.882 1.00 19.47 O ATOM 6136 C GLU A 865 −47.133 33.999 −47.394 1.00 17.27 C ATOM 6137 O GLU A 865 −47.114 35.149 −46.993 1.00 18.15 O ATOM 6138 N VAL A 866 −46.590 33.634 −48.537 1.00 16.73 N ATOM 6139 CA VAL A 866 −45.681 34.491 −49.268 1.00 16.17 C ATOM 6140 CB VAL A 866 −44.231 34.187 −48.838 1.00 16.30 C ATOM 6141 CG1 VAL A 866 −43.260 34.663 −49.882 1.00 16.93 C ATOM 6142 CG2 VAL A 866 −43.902 34.819 −47.494 1.00 16.26 C ATOM 6143 C VAL A 866 −45.885 34.101 −50.722 1.00 16.06 C ATOM 6144 O VAL A 866 −45.994 32.920 −51.024 1.00 16.42 O ATOM 6145 N LYS A 867 −45.970 35.069 −51.626 1.00 15.94 N ATOM 6146 CA LYS A 867 −46.364 34.744 −52.999 1.00 15.86 C ATOM 6147 CB LYS A 867 −47.088 35.914 −53.675 1.00 15.25 C ATOM 6148 C LYS A 867 −45.161 34.286 −53.814 1.00 16.01 C ATOM 6149 O LYS A 867 −44.887 34.841 −54.879 1.00 16.36 O ATOM 6150 N GLY A 868 −44.449 33.275 −53.305 1.00 15.49 N ATOM 6151 CA GLY A 868 −43.309 32.690 −53.996 1.00 15.45 C ATOM 6152 C GLY A 868 −42.417 31.871 −53.083 1.00 15.82 C ATOM 6153 O GLY A 868 −42.809 31.531 −51.960 1.00 15.79 O ATOM 6154 N ALA A 869 −41.208 31.563 −53.564 1.00 16.01 N ATOM 6155 CA ALA A 869 −40.247 30.721 −52.834 1.00 15.79 C ATOM 6156 CB ALA A 869 −39.318 30.023 −53.809 1.00 15.94 C ATOM 6157 C ALA A 869 −39.430 31.522 −51.833 1.00 15.79 C ATOM 6158 O ALA A 869 −39.037 32.663 −52.111 1.00 15.90 O ATOM 6159 N VAL A 870 −39.166 30.920 −50.676 1.00 15.35 N ATOM 6160 CA VAL A 870 −38.319 31.548 −49.664 1.00 14.82 C ATOM 6161 CB VAL A 870 −38.820 31.298 −48.228 1.00 14.64 C ATOM 6162 CG1 VAL A 870 −38.094 32.204 −47.249 1.00 14.60 C ATOM 6163 CG2 VAL A 870 −40.310 31.548 −48.137 1.00 14.99 C ATOM 6164 C VAL A 870 −36.945 30.953 −49.790 1.00 14.56 C ATOM 6165 O VAL A 870 −36.597 30.052 −49.027 1.00 14.77 O ATOM 6166 N TYR A 871 −36.171 31.453 −50.755 1.00 14.30 N ATOM 6167 CA TYR A 871 −34.838 30.921 −51.048 1.00 14.32 C ATOM 6168 CB TYR A 871 −34.255 31.518 −52.338 1.00 14.19 C ATOM 6169 CG TYR A 871 −35.026 31.193 −53.599 1.00 14.01 C ATOM 6170 CD1 TYR A 871 −35.224 29.872 −53.999 1.00 14.01 C ATOM 6171 CE1 TYR A 871 −35.934 29.565 −55.146 1.00 14.17 C ATOM 6172 CZ TYR A 871 −36.441 30.586 −55.924 1.00 14.58 C ATOM 6173 OH TYR A 871 −37.141 30.285 −57.081 1.00 14.78 O ATOM 6174 CE2 TYR A 871 −39.247 31.911 −55.549 1.00 14.76 C ATOM 6175 CD2 TYR A 871 −35.539 32.202 −54.396 1.00 14.12 C ATOM 6176 C TYR A 871 −33.851 31.099 −49.903 1.00 14.64 C ATOM 6177 O TYR A 871 −33.111 30.192 −49.600 1.00 15.77 O ATOM 6178 N SER A 872 −33.847 32.255 −49.258 1.00 14.94 N ATOM 6179 CA SER A 872 −32.833 32.559 −48.250 1.00 15.03 C ATOM 6180 CB SER A 872 −31.726 33.437 −48.847 1.00 15.37 C ATOM 6181 OG SER A 872 −30.672 32.662 −49.415 1.00 16.09 O ATOM 6182 C SER A 872 −33.452 33.292 −47.092 1.00 15.16 C ATOM 6183 O SER A 872 −34.473 33.953 −47.240 1.00 15.75 O ATOM 6184 N MET A 873 −32.828 33.171 −45.933 1.00 14.86 N ATOM 6185 CA MET A 873 −33.234 33.898 −44.760 1.00 14.39 C ATOM 6186 CB MET A 873 −34.198 33.069 −43.940 1.00 14.22 C ATOM 6187 CG MET A 873 −35.631 33.089 −44.435 1.00 14.28 C ATOM 6188 SD MET A 873 −36.769 32.483 −43.170 1.00 14.34 S ATOM 6189 CE MET A 873 −36.397 30.738 −43.128 1.00 14.06 C ATOM 6190 C MET A 873 −31.992 34.188 −43.944 1.00 14.67 C ATOM 6191 O MET A 873 −31.103 33.351 −43.847 1.00 14.85 O ATOM 6192 N VAL A 874 −31.917 35.390 −43.389 1.00 14.86 N ATOM 6193 CA VAL A 874 −30.857 35.756 −42.470 1.00 15.32 C ATOM 6194 CB VAL A 874 −29.661 36.441 −43.189 1.00 15.14 C ATOM 6195 CG1 VAL A 874 −30.111 37.193 −44.415 1.00 15.33 C ATOM 6196 CG2 VAL A 874 −28.921 37.390 −42.258 1.00 15.37 C ATOM 6197 C VAL A 874 −31.459 36.646 −41.389 1.00 15.99 C ATOM 6198 O VAL A 874 −32.275 37.508 −41.679 1.00 15.91 O ATOM 6199 N GLU A 875 −31.081 36.405 −40.138 1.00 17.16 N ATOM 6200 CA GLU A 875 −31.553 37.219 −39.025 1.00 17.94 C ATOM 6201 CB GLU A 875 −31.256 36.500 −37.698 1.00 18.13 C ATOM 6202 CG GLU A 875 −31.589 37.298 −36.451 1.00 19.31 C ATOM 6203 CD GLU A 875 −30.455 38.221 −36.023 1.00 20.48 C ATOM 6204 OE1 GLU A 875 −29.276 37.811 −36.144 1.00 21.11 O ATOM 6205 OE2 GLU A 875 −30.735 39.357 −35.562 1.00 21.41 O ATOM 6206 C GLU A 875 −30.865 38.586 −39.119 1.00 18.20 C ATOM 6207 O GLU A 875 −29.652 38.648 −39.238 1.00 18.93 O ATOM 6208 N PHE A 876 −31.631 39.673 −39.081 1.00 18.34 N ATOM 6209 CA PHE A 876 −31.096 40.993 −39.441 1.00 18.84 C ATOM 6210 CB PHE A 876 −31.546 41.345 −40.871 1.00 18.30 C ATOM 6211 CG PHE A 876 −31.019 42.655 −41.388 1.00 18.57 C ATOM 6212 CD1 PHE A 876 −29.737 42.749 −41.913 1.00 18.90 C ATOM 6213 CE1 PHE A 876 −29.250 43.959 −42.408 1.00 18.87 C ATOM 6214 CZ PHE A 876 −30.054 45.082 −42.389 1.00 18.68 C ATOM 6215 CE2 PHE A 876 −31.342 44.999 −41.876 1.00 18.57 C ATOM 6216 CD2 PHE A 876 −31.820 43.794 −41.387 1.00 18.61 C ATOM 6217 C PHE A 876 −31.457 42.100 −38.416 1.00 19.67 C ATOM 6218 O PHE A 876 −32.474 42.791 −38.545 1.00 19.85 O ATOM 6219 N ASN A 877 −30.608 42.254 −37.402 1.00 20.32 N ATOM 6220 CA ASN A 877 −30.802 43.251 −36.328 1.00 20.68 C ATOM 6221 CB ASN A 877 −30.671 44.687 −36.867 1.00 21.74 C ATOM 6222 CG ASN A 877 −29.333 44.946 −37.538 1.00 23.18 C ATOM 6223 OD1 ASN A 877 −28.284 44.515 −37.053 1.00 24.06 O ATOM 6224 ND2 ASN A 877 −29.362 45.666 −38.661 1.00 23.89 N ATOM 6225 C ASN A 877 −32.107 43.082 −35.527 1.00 19.97 C ATOM 6226 O ASN A 877 −32.793 44.057 −35.207 1.00 20.02 O ATOM 6227 N GLY A 878 −32.435 41.838 −35.199 1.00 18.87 N ATOM 6228 CA GLY A 878 −33.661 41.546 −34.483 1.00 17.41 C ATOM 6229 C GLY A 878 −34.854 41.438 −35.404 1.00 16.56 C ATOM 6230 O GLY A 878 −35.960 41.145 −34.961 1.00 16.75 O ATOM 6231 N LYS A 879 −34.638 41.673 −36.691 1.00 16.01 N ATOM 6232 CA LYS A 879 −35.701 41.502 −37.684 1.00 15.34 C ATOM 6233 CB LYS A 879 −35.863 42.768 −38.527 1.00 15.33 C ATOM 6234 CG LYS A 879 −35.791 44.053 −37.726 1.00 15.23 C ATOM 6235 CD LYS A 879 −36.216 45.234 −38.560 1.00 15.63 C ATOM 6236 CE LYS A 879 −35.563 46.519 −38.072 1.00 16.14 C ATOM 6237 NZ LYS A 879 −36.464 47.693 −38.286 1.00 16.72 N ATOM 6238 C LYS A 879 −35.347 40.320 −38.562 1.00 14.81 C ATOM 6239 O LYS A 879 −34.222 39.821 −38.501 1.00 15.06 O ATOM 6240 N LEU A 880 −36.298 39.862 −39.372 1.00 14.12 N ATOM 6241 CA LEU A 880 −36.039 38.742 −40.277 1.00 13.58 C ATOM 6242 CB LEU A 880 −37.090 37.654 −40.115 1.00 13.32 C ATOM 6243 CG LEU A 880 −36.855 36.335 −40.837 1.00 13.28 C ATOM 6244 CD1 LEU A 880 −35.807 35.522 −40.103 1.00 13.41 C ATOM 6245 CD2 LEU A 880 −38.150 32.557 −40.932 1.00 13.17 C ATOM 6246 C LEU A 880 −35.968 39.199 −41.727 1.00 13.42 C ATOM 6247 O LEU A 880 −36.889 39.825 −42.242 1.00 13.50 O ATOM 6248 N LEU A 881 −34.851 38.887 −42.365 1.00 13.30 N ATOM 6249 CA LEU A 881 −34.600 39.270 −43.725 1.00 13.45 C ATOM 6250 CB LEU A 881 −33.198 39.848 −43.849 1.00 13.45 C ATOM 6251 CG LEU A 881 −32.787 40.620 −45.104 1.00 13.67 C ATOM 6252 CD1 LEU A 881 −33.792 41.702 −45.479 1.00 13.62 C ATOM 6253 CD2 LEU A 881 −31.394 41.221 −44.918 1.00 13.76 C ATOM 6254 C LEU A 881 −34.736 38.019 −44.552 1.00 13.87 C ATOM 6255 O LEU A 881 −34.050 37.034 −44.310 1.00 13.86 O ATOM 6256 N ALA A 882 −35.653 38.062 −45.516 1.00 14.49 N ATOM 6257 CA ALA A 882 −35.995 36.911 −46.342 1.00 14.46 C ATOM 6258 CB ALA A 882 −37.376 36.390 −45.989 1.00 14.50 C ATOM 6259 C ALA A 882 −35.987 37.344 −47.763 1.00 14.68 C ATOM 6260 O ALA A 882 −36.498 38.403 −48.087 1.00 14.52 O ATOM 6261 N SER A 883 −35.401 36.518 −48.612 1.00 15.72 N ATOM 6262 CA SER A 883 −35.453 36.730 −50.044 1.00 16.80 C ATOM 6263 CB SER A 883 −34.091 36.456 −50.678 1.00 17.05 C ATOM 6264 OG SER A 883 −33.835 35.069 −50.773 1.00 16.98 O ATOM 6265 C SER A 883 −36.510 35.804 −50.620 1.00 17.41 C ATOM 6266 O SER A 883 −36.413 34.584 −50.474 1.00 17.48 O ATOM 6267 N ILE A 884 −37.528 36.401 −51.241 1.00 18.05 N ATOM 6268 CA ILE A 884 −38.632 35.666 −51.858 1.00 18.69 C ATOM 6269 CB ILE A 884 −39.964 36.009 −51.207 1.00 18.68 C ATOM 6270 CG1 ILE A 884 −39.858 35.848 −49.682 1.00 19.18 C ATOM 6271 CD1 ILE A 884 −40.834 36.715 −48.907 1.00 19.36 C ATOM 6272 CG2 ILE A 884 −41.065 35.175 −51.842 1.00 17.71 C ATOM 6273 C ILE A 884 −38.761 35.979 −53.342 1.00 19.52 C ATOM 6274 O ILE A 884 −38.956 37.139 −53.738 1.00 19.60 O ATOM 6275 N ASN A 885 −38.707 34.921 −54.148 1.00 20.36 N ATOM 6276 CA ASN A 885 −38.455 35.028 −55.586 1.00 20.32 C ATOM 6277 CB ASN A 885 −39.753 35.193 −56.393 1.00 20.59 C ATOM 6278 CG ASN A 885 −40.620 33.929 −56.364 1.00 21.61 C ATOM 6279 OD1 ASN A 885 −40.107 32.798 −56.372 1.00 22.03 O ATOM 6280 ND2 ASN A 885 −41.936 34.114 −56.318 1.00 21.07 N ATOM 6281 C ASN A 885 −37.415 36.097 −55.869 1.00 20.10 C ATOM 6282 O ASN A 885 −36.254 35.941 −55.473 1.00 20.00 O ATOM 6283 N SER A 886 −37.822 37.185 −56.512 1.00 19.72 N ATOM 6284 CA SER A 886 −36.886 38.239 −56.874 1.00 19.27 C ATOM 6285 CB SER A 886 −37.020 38.572 −58.346 1.00 19.09 C ATOM 6286 OG SER A 886 −38.314 39.070 −58.613 1.00 19.98 O ATOM 6287 C SER A 886 −37.132 39.469 −56.019 1.00 19.37 C ATOM 6288 O SER A 886 −36.973 40.611 −56.478 1.00 19.53 O ATOM 6289 N THR A 887 −37.531 39.220 −54.772 1.00 19.12 N ATOM 6290 CA THR A 887 −37.837 40.274 −53.813 1.00 18.61 C ATOM 6291 CB THR A 887 −39.352 40.337 −53.514 1.00 18.48 C ATOM 6292 OG1 THR A 887 −40.026 40.885 −54.650 1.00 18.74 O ATOM 6293 CG2 THR A 887 −39.649 41.229 −52.330 1.00 18.65 C ATOM 6294 C THR A 887 −37.058 40.020 −52.544 1.00 18.12 C ATOM 6295 O THR A 887 −36.906 38.876 −52.132 1.00 18.21 O ATOM 6296 N VAL A 888 −36.538 41.088 −51.950 1.00 17.77 N ATOM 6297 CA VAL A 888 −35.946 41.016 −50.618 1.00 17.71 C ATOM 6298 CB VAL A 888 −34.512 41.598 −50.581 1.00 18.13 C ATOM 6299 CG1 VAL A 888 −33.995 41.691 −49.154 1.00 18.02 C ATOM 6300 CG2 VAL A 888 −33.569 40.738 −51.412 1.00 18.14 C ATOM 6301 C VAL A 888 −36.875 41.734 −49.645 1.00 17.36 C ATOM 6302 O VAL A 888 −37.309 42.846 −49.898 1.00 17.71 O ATOM 6303 N ARG A 889 −37.183 41.075 −48.537 1.00 17.20 N ATOM 6304 CA ARG A 889 −38.275 41.487 −47.667 1.00 16.90 C ATOM 6305 CB ARG A 889 −39.477 40.566 −47.909 1.00 17.07 C ATOM 6306 CG ARG A 889 −40.735 40.929 −47.150 1.00 17.58 C ATOM 6307 CD ARG A 889 −41.952 40.302 −47.801 1.00 18.12 C ATOM 6308 NE ARG A 889 −41.972 40.503 −49.252 1.00 18.75 N ATOM 6309 CZ ARG A 889 −42.761 39.828 −50.095 1.00 18.84 C ATOM 6310 NH1 ARG A 889 −43.607 38.918 −49.647 1.00 18.44 N ATOM 6311 NH2 ARG A 889 −42.703 40.093 −51.396 1.00 19.11 N ATOM 6312 C ARG A 889 −37.836 41.414 −46.211 1.00 16.41 C ATOM 6313 O ARG A 889 −37.237 40.422 −45.775 1.00 15.81 O ATOM 6314 N LEU A 890 −38.133 42.467 −45.462 1.00 16.00 N ATOM 6315 CA LEU A 890 −37.735 42.532 −44.071 1.00 16.25 C ATOM 6316 CB LEU A 890 −36.936 43.808 −43.818 1.00 16.26 C ATOM 6317 CG LEU A 890 −36.307 44.014 −42.438 1.00 16.53 C ATOM 6318 CD1 LEU A 890 −35.339 42.887 −42.098 1.00 16.40 C ATOM 6319 CD2 LEU A 890 −35.614 45.374 −42.369 1.00 16.61 C ATOM 6320 C LEU A 890 −38.967 42.471 −43.185 1.00 16.53 C ATOM 6321 O LEU A 890 −39.934 43.170 −43.435 1.00 16.79 O ATOM 6322 N TYR A 891 −38.922 41.634 −42.151 1.00 16.83 N ATOM 6323 CA TYR A 891 −40.093 41.353 −41.306 1.00 16.82 C ATOM 6324 CB TYR A 891 −40.389 39.845 −41.309 1.00 16.58 C ATOM 6325 CG TYR A 891 −40.942 39.316 −42.621 1.00 16.48 C ATOM 6326 CD1 TYR A 891 −42.275 39.540 −42.981 1.00 16.57 C ATOM 6327 CE1 TYR A 891 −42.791 39.062 −44.168 1.00 16.35 C ATOM 6328 CZ TYR A 891 −41.979 38.347 −45.016 1.00 16.63 C ATOM 6329 OH TYR A 891 −42.495 37.875 −46.197 1.00 16.85 O ATOM 6330 CE2 TYR A 891 −40.655 38.106 −44.689 1.00 16.65 C ATOM 6331 CD2 TYR A 891 −40.144 38.589 −43.493 1.00 16.42 C ATOM 6332 C TYR A 891 −39.826 41.789 −39.884 1.00 17.09 C ATOM 6333 O TYR A 891 −38.736 41.532 −39.371 1.00 17.71 O ATOM 6334 N GLU A 892 −40.800 42.442 −39.244 1.00 17.35 N ATOM 6335 CA GLU A 892 −40.727 42.724 −37.792 1.00 17.65 C ATOM 6336 CB GLU A 892 −41.206 44.143 −37.457 1.00 18.74 C ATOM 6337 CG GLU A 892 −40.108 45.206 −37.533 1.00 20.80 C ATOM 6338 CD GLU A 892 −40.602 46.623 −37.194 1.00 22.45 C ATOM 6339 OE1 GLU A 892 −40.709 46.975 −35.989 1.00 22.80 O ATOM 6340 OE2 GLU A 892 −40.869 47.404 −38.138 1.00 23.46 O ATOM 6341 C GLU A 892 −41.510 41.679 −36.990 1.00 17.03 C ATOM 6342 O GLU A 892 −42.537 41.184 −37.447 1.00 16.91 O ATOM 6343 N TRP A 893 −41.009 41.340 −35.806 1.00 16.58 N ATOM 6344 CA TRP A 893 −41.624 40.332 −34.950 1.00 16.49 C ATOM 6345 CB TRP A 893 −40.546 39.423 −34.394 1.00 16.33 C ATOM 6346 CG TRP A 893 −41.040 38.239 −33.592 1.00 16.06 C ATOM 6347 CD1 TRP A 893 −40.755 37.937 −32.265 1.00 15.88 C ATOM 6348 NE1 TRP A 893 −41.363 36.770 −31.887 1.00 15.87 N ATOM 6349 CE2 TRP A 893 −42.062 36.245 −32.911 1.00 16.00 C ATOM 6350 CD2 TRP A 893 −41.890 37.140 −34.056 1.00 16.02 C ATOM 6351 CE3 TRP A 893 −42.519 36.827 −35.260 1.00 16.25 C ATOM 6352 CZ3 TRP A 893 −43.290 35.664 −35.327 1.00 16.26 C ATOM 6353 CH2 TRP A 893 −43.446 34.819 −34.214 1.00 16.36 C ATOM 6354 CZ2 TRP A 893 −42.830 35.094 −32.987 1.00 16.22 C ATOM 6355 C TRP A 893 −42.366 40.995 −33.830 1.00 17.01 C ATOM 6356 O TRP A 893 −41.759 41.490 −32.884 1.00 17.17 O ATOM 6357 N THR A 894 −43.692 40.997 −33.926 1.00 17.68 N ATOM 6358 CA THR A 894 −44.548 41.765 −33.019 1.00 18.58 C ATOM 6359 CB THR A 894 −45.905 42.064 −33.674 1.00 18.22 C ATOM 6360 OG1 THR A 894 −46.649 40.850 −33.792 1.00 18.43 O ATOM 6361 CG2 THR A 894 −45.713 42.650 −35.057 1.00 18.19 C ATOM 6362 C THR A 894 −44.777 41.045 −31.677 1.00 19.68 C ATOM 6363 O THR A 894 −44.288 39.932 −31.462 1.00 19.77 O ATOM 6364 N THR A 895 −45.513 41.683 −30.772 1.00 20.47 N ATOM 6365 CA THR A 895 −45.857 41.031 −29.513 1.00 21.49 C ATOM 6366 CB THR A 895 −46.065 42.037 −28.354 1.00 21.98 C ATOM 6367 OG1 THR A 895 −47.124 42.948 −28.687 1.00 22.01 O ATOM 6368 CG2 THR A 895 −44.759 42.809 −28.030 1.00 21.43 C ATOM 6369 C THR A 895 −47.105 40.167 −29.685 1.00 21.83 C ATOM 6370 O THR A 895 −47.398 39.310 −28.853 1.00 22.31 O ATOM 6371 N GLU A 896 −47.841 40.398 −30.766 1.00 22.28 N ATOM 6372 CA GLU A 896 −48.968 39.538 −31.110 1.00 22.72 C ATOM 6373 CB GLU A 896 −49.851 40.186 −32.189 1.00 22.55 C ATOM 6374 C GLU A 896 −48.409 38.199 −31.581 1.00 23.10 C ATOM 6375 O GLU A 896 −49.162 37.256 −31.847 1.00 23.13 O ATOM 6376 N LYS A 897 −47.075 38.133 −31.650 1.00 23.63 N ATOM 6377 CA LYS A 897 −46.324 36.933 −32.058 1.00 24.67 C ATOM 6378 CB LYS A 897 −46.574 35.767 −31.088 1.00 23.88 C ATOM 6379 CG LYS A 897 −45.329 34.958 −30.756 1.00 23.49 C ATOM 6380 CD LYS A 897 −45.302 34.458 −29.313 1.00 23.13 C ATOM 6381 CE LYS A 897 −44.833 35.558 −28.374 1.00 23.60 C ATOM 6382 NZ LYS A 897 −44.503 35.039 −27.019 1.00 24.01 N ATOM 6383 C LYS A 897 −46.580 36.568 −33.545 1.00 25.81 C ATOM 6384 O LYS A 897 −46.935 35.431 −33.892 1.00 25.41 O ATOM 6385 N GLU A 898 −46.381 37.570 −34.403 1.00 26.30 N ATOM 6386 CA GLU A 898 −46.616 37.461 −35.822 1.00 27.13 C ATOM 6387 CB GLU A 898 −47.990 38.056 −36.172 1.00 30.59 C ATOM 6388 CG GLU A 898 −48.918 37.135 −36.972 1.00 35.94 C ATOM 6389 CD GLU A 898 −48.433 36.849 −38.412 1.00 41.31 C ATOM 6390 OE1 GLU A 898 −47.466 36.049 −38.589 1.00 40.98 O ATOM 6391 OE2 GLU A 898 −49.039 37.402 −39.377 1.00 41.89 O ATOM 6392 C GLU A 898 −45.498 38.227 −36.530 1.00 25.32 C ATOM 6393 O GLU A 898 −44.866 39.090 −35.928 1.00 23.86 O ATOM 6394 N LEU A 899 −45.239 37.865 −37.790 1.00 24.76 N ATOM 6395 CA LEU A 899 −44.238 38.517 −38.641 1.00 24.01 C ATOM 6396 CB LEU A 899 −43.544 37.504 −39.552 1.00 22.22 C ATOM 6397 CG LEU A 899 −42.512 36.524 −39.022 1.00 21.35 C ATOM 6398 CD1 LEU A 899 −42.298 35.403 −40.026 1.00 21.07 C ATOM 6399 CD2 LEU A 899 −41.211 37.247 −38.762 1.00 21.37 C ATOM 6400 C LEU A 899 −44.950 39.512 −39.519 1.00 25.43 C ATOM 6401 O LEU A 899 −45.770 39.120 −40.349 1.00 26.96 O ATOM 6402 N ARG A 900 −44.624 40.791 −39.355 1.00 25.97 N ATOM 6403 CA ARG A 900 −45.360 41.882 −39.998 1.00 26.03 C ATOM 6404 CB ARG A 900 −46.022 42.757 −38.896 1.00 27.98 C ATOM 6405 CG ARG A 900 −46.954 43.901 −39.331 1.00 31.45 C ATOM 6406 CD ARG A 900 −48.448 43.537 −39.491 1.00 34.20 C ATOM 6407 NE ARG A 900 −49.036 42.779 −38.372 1.00 35.31 N ATOM 6408 CZ ARG A 900 −49.384 41.487 −38.424 1.00 35.67 C ATOM 6409 NH1 ARG A 900 −49.216 40.786 −39.542 1.00 36.08 N ATOM 6410 NH2 ARG A 900 −49.904 40.888 −37.354 1.00 35.17 N ATOM 6411 C ARG A 900 −44.389 42.665 −40.925 1.00 24.45 C ATOM 6412 O ARG A 900 −43.506 43.375 −40.445 1.00 24.91 O ATOM 6413 N THR A 901 −44.546 42.485 −42.242 1.00 22.09 N ATOM 6414 CA THR A 901 −43.694 43.097 −43.275 1.00 20.24 C ATOM 6415 CB THR A 901 −44.339 43.006 −44.671 1.00 19.55 C ATOM 6416 OG1 THR A 901 −44.862 41.702 −44.878 1.00 19.98 O ATOM 6417 CG2 THR A 901 −43.334 43.293 −45.764 1.00 19.67 C ATOM 6418 C THR A 901 −43.426 44.570 −43.034 1.00 20.28 C ATOM 6419 O THR A 901 −44.354 45.371 −43.023 1.00 20.42 O ATOM 6420 N GLU A 902 −42.153 44.925 −42.862 1.00 20.49 N ATOM 6421 CA GLU A 902 −41.758 46.317 −42.717 1.00 20.35 C ATOM 6422 CB GLU A 902 −40.547 46.488 −41.801 1.00 20.52 C ATOM 6423 CG GLU A 902 −40.178 47.954 −41.575 1.00 20.98 C ATOM 6424 CD GLU A 902 −38.758 48.165 −41.046 1.00 21.77 C ATOM 6425 OE1 GLU A 902 −38.151 47.206 −40.514 1.00 22.18 O ATOM 6426 OE2 GLU A 902 −38.244 49.305 −41.152 1.00 21.77 O ATOM 6427 C GLU A 902 −41.472 46.920 −44.068 1.00 20.48 C ATOM 6428 O GLU A 902 −41.912 48.036 −44.334 1.00 21.13 O ATOM 6429 N CYS A 903 −40.731 46.198 −44.912 1.00 20.24 N ATOM 6430 CA CYS A 903 −40.402 46.684 −46.259 1.00 20.66 C ATOM 6431 CB CYS A 903 −39.445 47.869 −46.212 1.00 20.57 C ATOM 6432 SG CYS A 903 −37.782 47.452 −45.668 1.00 21.54 S ATOM 6433 C CYS A 903 −39.881 45.613 −47.217 1.00 21.58 C ATOM 6434 O CYS A 903 −39.724 44.442 −46.853 1.00 22.64 O ATOM 6435 N ASN A 904 −39.576 46.043 −48.435 1.00 21.65 N ATOM 6436 CA ASN A 904 −39.694 45.196 −49.593 1.00 21.99 C ATOM 6437 CB ASN A 904 −41.166 45.191 −49.986 1.00 22.04 C ATOM 6438 CG ASN A 904 −41.515 44.087 −50.945 1.00 22.86 C ATOM 6439 OD1 ASN A 904 −41.738 42.937 −50.541 1.00 22.71 O ATOM 6440 ND2 ASN A 904 −41.603 44.431 −52.229 1.00 23.05 N ATOM 6441 C ASN A 904 −38.879 45.789 −50.726 1.00 23.02 C ATOM 6442 O ASN A 904 −39.012 46.967 −51.013 1.00 24.75 O ATOM 6443 N HIS A 905 −38.041 44.986 −51.379 1.00 23.95 N ATOM 6444 CA HIS A 905 −37.214 45.485 −52.489 1.00 24.08 C ATOM 6445 CB HIS A 905 −35.794 45.764 −52.024 1.00 24.63 C ATOM 6446 CG HIS A 905 −35.008 46.646 −52.968 1.00 25.31 C ATOM 6447 ND1 HIS A 905 −34.040 46.165 −53.777 1.00 25.28 N ATOM 6448 CE1 HIS A 905 −33.510 47.178 −54.493 1.00 25.54 C ATOM 6449 NE2 HIS A 905 −34.146 48.314 −54.143 1.00 25.75 N ATOM 6450 CD2 HIS A 905 −35.076 48.023 −53.208 1.00 25.43 C ATOM 6451 C HIS A 905 −37.195 44.571 −53.675 1.00 23.79 C ATOM 6452 O HIS A 905 −36.843 43.402 −53.564 1.00 23.89 O ATOM 6453 N TYR A 906 −37.571 45.110 −54.828 1.00 24.09 N ATOM 6454 CA TYR A 906 −37.627 44.344 −56.070 1.00 24.63 C ATOM 6455 CB TYR A 906 −38.769 44.847 −56.944 1.00 25.38 C ATOM 6456 CG TYR A 906 −40.118 44.854 −56.270 1.00 26.41 C ATOM 6457 CD1 TYR A 906 −40.861 43.675 −56.143 1.00 26.94 C ATOM 6458 CE1 TYR A 906 −42.104 43.671 −55.536 1.00 28.09 C ATOM 6459 CZ TYR A 906 −42.629 44.864 −55.057 1.00 28.94 C ATOM 6460 OH TYR A 906 −43.870 44.864 −54.453 1.00 30.01 O ATOM 6461 CE2 TYR A 906 −41.912 46.050 −55.178 1.00 28.05 C ATOM 6462 CD2 TYR A 906 −40.667 46.039 −55.781 1.00 26.63 C ATOM 6463 C TYR A 906 −36.330 44.492 −56.840 1.00 24.21 C ATOM 6464 O TYR A 906 −35.773 45.580 −56.905 1.00 25.09 O ATOM 6465 N ASN A 907 −35.861 43.410 −57.445 1.00 22.99 N ATOM 6466 CA ASN A 907 −34.583 43.437 −58.123 1.00 22.83 C ATOM 6467 CB ASN A 907 −33.573 42.525 −57.397 1.00 23.30 C ATOM 6468 CG ASN A 907 −33.578 42.703 −55.874 1.00 23.07 C ATOM 6469 OD1 ASN A 907 −33.465 43.819 −55.361 1.00 23.20 O ATOM 6470 ND2 ASN A 907 −33.692 41.590 −55.149 1.00 22.71 N ATOM 6471 C ASN A 907 −34.755 42.967 −59.552 1.00 23.33 C ATOM 6472 O ASN A 907 −35.815 42.455 −59.908 1.00 23.56 O ATOM 6473 N ASN A 908 −33.708 43.133 −60.364 1.00 24.13 N ATOM 6474 CA ASN A 908 −33.625 42.540 −61.719 1.00 24.04 C ATOM 6475 CB ASN A 908 −32.570 43.264 −62.525 1.00 24.76 C ATOM 6476 CG ASN A 908 −32.828 44.724 −62.604 1.00 27.19 C ATOM 6477 OD1 ASN A 908 −31.916 45.537 −62.443 1.00 29.04 O ATOM 6478 ND2 ASN A 908 −34.091 45.087 −62.838 1.00 27.98 N ATOM 6479 C ASN A 908 −33.252 41.060 −61.737 1.00 23.61 C ATOM 6480 O ASN A 908 −33.055 40.468 −62.807 1.00 23.65 O ATOM 6481 N ILE A 909 −33.114 40.480 −60.553 1.00 22.41 N ATOM 6482 CA ILE A 909 −32.536 39.167 −60.405 1.00 22.04 C ATOM 6483 CB ILE A 909 −31.027 39.227 −60.088 1.00 21.03 C ATOM 6484 CG1 ILE A 909 −30.750 40.195 −58.945 1.00 20.08 C ATOM 6485 CD1 ILE A 909 −29.529 39.844 −58.152 1.00 20.02 C ATOM 6486 CG2 ILE A 909 −30.239 39.616 −61.324 1.00 21.43 C ATOM 6487 C ILE A 909 −33.245 38.468 −59.276 1.00 22.47 C ATOM 6488 O ILE A 909 −33.775 39.114 −58.372 1.00 22.85 O ATOM 6489 N MET A 910 −33.253 37.147 −59.331 1.00 22.52 N ATOM 6490 CA MET A 910 −33.905 36.371 −58.319 1.00 23.20 C ATOM 6491 CB MET A 910 −34.227 34.996 −58.876 1.00 25.81 C ATOM 6492 CG MET A 910 −34.409 33.908 −57.835 1.00 29.32 C ATOM 6493 SD MET A 910 −34.334 32.291 −58.629 1.00 35.22 S ATOM 6494 CE MET A 910 −35.155 32.681 −60.191 1.00 31.75 C ATOM 6495 C MET A 910 −32.979 36.294 −57.114 1.00 22.33 C ATOM 6496 O MET A 910 −31.869 35.789 −57.209 1.00 23.39 O ATOM 6497 N ALA A 911 −33.423 36.816 −55.983 1.00 20.90 N ATOM 6498 CA ALA A 911 −32.588 36.817 −54.791 1.00 19.92 C ATOM 6499 CB ALA A 911 −33.184 37.733 −53.741 1.00 19.82 C ATOM 6500 C ALA A 911 −32.344 35.402 −54.226 1.00 19.23 C ATOM 6501 O ALA A 911 −32.993 34.987 −53.253 1.00 18.64 O ATOM 6502 N LEU A 912 −31.421 34.668 −54.858 1.00 18.33 N ATOM 6503 CA LEU A 912 −31.011 33.336 −54.393 1.00 17.58 C ATOM 6504 CB LEU A 912 −30.129 32.637 −55.420 1.00 17.42 C ATOM 6505 CG LEU A 912 −30.671 31.507 −56.284 1.00 17.74 C ATOM 6506 CD1 LEU A 912 −29.510 30.605 −56.676 1.00 17.19 C ATOM 6507 CD2 LEU A 912 −31.744 30.693 −55.578 1.00 17.62 C ATOM 6508 C LEU A 912 −30.223 33.435 −53.106 1.00 17.16 C ATOM 6509 O LEU A 912 −30.537 32.761 −52.124 1.00 17.62 O ATOM 6510 N TYR A 913 −29.197 34.282 −53.121 1.00 16.25 N ATOM 6511 CA TYR A 913 −28.253 34.378 −52.019 1.00 15.58 C ATOM 6512 CB TYR A 913 −26.837 34.384 −52.555 1.00 14.89 C ATOM 6513 CG TYR A 913 −26.491 33.172 −53.365 1.00 14.41 C ATOM 6514 CD1 TYR A 913 −26.161 31.978 −52.747 1.00 13.89 C ATOM 6515 CE1 TYR A 913 −25.814 30.864 −53.486 1.00 13.66 C ATOM 6516 CZ TYR A 913 −25.795 30.935 −54.860 1.00 13.75 C ATOM 6517 OH TYR A 913 −25.475 29.824 −55.578 1.00 13.46 O ATOM 6518 CE2 TYR A 913 −26.113 32.114 −55.513 1.00 14.22 C ATOM 6519 CD2 TYR A 913 −26.467 33.227 −54.763 1.00 14.52 C ATOM 6520 C TYR A 913 −28.466 35.623 −51.194 1.00 15.43 C ATOM 6521 O TYR A 913 −28.671 36.707 −51.734 1.00 15.90 O ATOM 6522 N LEU A 914 −28.425 35.460 −49.882 1.00 15.17 N ATOM 6523 CA LEU A 914 −28.577 36.568 −48.975 1.00 15.69 C ATOM 6524 CB LEU A 914 −29.955 36.565 −48.330 1.00 15.79 C ATOM 6525 CG LEU A 914 −30.979 37.622 −48.709 1.00 15.92 C ATOM 6526 CD1 LEU A 914 −31.989 37.768 −47.583 1.00 15.73 C ATOM 6527 CD2 LEU A 914 −30.288 38.948 −48.961 1.00 16.28 C ATOM 6528 C LEU A 914 −27.549 36.437 −47.898 1.00 16.34 C ATOM 6529 O LEU A 914 −27.436 35.387 −47.269 1.00 16.79 O ATOM 6530 N LYS A 915 −26.781 37.500 −47.696 1.00 16.99 N ATOM 6531 CA LYS A 915 −25.812 37.569 −46.608 1.00 17.29 C ATOM 6532 CB LYS A 915 −24.427 37.106 −47.080 1.00 17.36 C ATOM 6533 CG LYS A 915 −24.354 35.681 −47.637 1.00 17.31 C ATOM 6534 CD LYS A 915 −24.739 34.630 −46.605 1.00 17.57 C ATOM 6535 CE LYS A 915 −24.187 33.250 −46.949 1.00 17.81 C ATOM 6536 NZ LYS A 915 −22.750 33.079 −46.541 1.00 17.47 N ATOM 6537 C LYS A 915 −25.777 39.013 −46.093 1.00 17.36 C ATOM 6538 O LYS A 915 −26.077 39.946 −46.837 1.00 16.98 O ATOM 6539 N THR A 916 −25.451 39.194 −44.817 1.00 17.73 N ATOM 6540 CA THR A 916 −25.489 40.521 −44.224 1.00 18.65 C ATOM 6541 CB THR A 916 −26.778 40.760 −43.425 1.00 18.65 C ATOM 6542 OG1 THR A 916 −26.740 39.980 −42.227 1.00 19.21 O ATOM 6543 CG2 THR A 916 −28.002 40.380 −44.233 1.00 18.47 C ATOM 6544 C THR A 916 −24.331 40.769 −43.279 1.00 19.49 C ATOM 6545 O THR A 916 −23.892 39.859 −42.576 1.00 19.80 O ATOM 6546 N LYS A 917 −23.849 42.011 −43.279 1.00 20.39 N ATOM 6547 CA LYS A 917 −22.972 42.525 −42.235 1.00 21.24 C ATOM 6548 CB LYS A 917 −21.522 42.611 −42.712 1.00 20.85 C ATOM 6549 CG LYS A 917 −20.568 43.057 −41.618 1.00 21.10 C ATOM 6550 CD LYS A 917 −19.157 43.326 −42.113 1.00 21.45 C ATOM 6551 CE LYS A 917 −18.205 43.376 −40.924 1.00 21.80 C ATOM 6552 NZ LYS A 917 −16.945 44.116 −41.213 1.00 22.54 N ATOM 6553 C LYS A 917 −23.468 43.917 −41.810 1.00 22.70 C ATOM 6554 O LYS A 917 −23.575 44.834 −42.645 1.00 23.05 O ATOM 6555 N GLY A 918 −23.763 44.069 −40.516 1.00 22.74 N ATOM 6556 CA GLY A 918 −24.237 45.329 −39.980 1.00 22.09 C ATOM 6557 C GLY A 918 −25.526 45.689 −40.669 1.00 23.04 C ATOM 6558 O GLY A 918 −26.546 45.013 −40.491 1.00 23.41 O ATOM 6559 N ASP A 919 −25.476 46.738 −41.482 1.00 23.64 N ATOM 6560 CA ASP A 919 −26.657 47.209 −42.180 1.00 24.44 C ATOM 6561 CB ASP A 919 −26.895 48.695 −41.913 1.00 25.73 C ATOM 6562 CG ASP A 919 −28.077 48.937 −40.979 1.00 27.71 C ATOM 6563 OD1 ASP A 919 −28.497 47.982 −40.275 1.00 28.90 O ATOM 6564 OD2 ASP A 919 −28.594 50.082 −40.952 1.00 28.45 O ATOM 6565 C ASP A 919 −26.585 46.935 −43.658 1.00 24.44 C ATOM 6566 O ASP A 919 −27.500 47.274 −44.400 1.00 24.92 O ATOM 6567 N PHE A 920 −25.494 46.311 −44.083 1.00 25.35 N ATOM 6568 CA PHE A 920 −25.289 45.972 −45.494 1.00 25.43 C ATOM 6569 CB PHE A 920 −23.796 46.017 −45.857 1.00 26.24 C ATOM 6570 CG PHE A 920 −23.225 47.405 −45.885 1.00 27.78 C ATOM 6571 CD1 PHE A 920 −22.947 48.086 −44.704 1.00 28.09 C ATOM 6572 CE1 PHE A 920 −22.436 49.379 −44.728 1.00 28.88 C ATOM 6573 CZ PHE A 920 −22.182 50.007 −45.941 1.00 29.19 C ATOM 6574 CE2 PHE A 920 −22.449 49.342 −47.129 1.00 30.49 C ATOM 6575 CD2 PHE A 920 −22.970 48.043 −47.097 1.00 30.23 C ATOM 6576 C PHE A 920 −25.901 44.611 −45.832 1.00 24.33 C ATOM 6577 O PHE A 920 −25.903 43.691 −45.004 1.00 23.33 O ATOM 6578 N ILE A 921 −26.437 44.506 −47.046 1.00 23.25 N ATOM 6579 CA ILE A 921 −27.041 43.273 −47.527 1.00 22.68 C ATOM 6580 CB ILE A 921 −28.580 43.406 −47.581 1.00 22.82 C ATOM 6581 CG1 ILE A 921 −29.168 43.373 −46.176 1.00 22.71 C ATOM 6582 CD1 ILE A 921 −30.288 44.371 −45.980 1.00 23.23 C ATOM 6583 CG2 ILE A 921 −29.206 42.286 −48.389 1.00 22.94 C ATOM 6584 C ILE A 921 −26.470 42.886 −48.899 1.00 22.26 C ATOM 6585 O LEU A 922 −26.465 43.692 −49.840 1.00 22.19 O ATOM 6586 N LEU A 922 −25.976 41.656 −48.992 1.00 21.51 N ATOM 6587 CA LEU A 922 −25.531 41.091 −50.254 1.00 21.58 C ATOM 6588 CB LEU A 922 −24.272 40.280 −50.054 1.00 21.28 C ATOM 6589 CG LEU A 922 −23.661 39.843 −51.369 1.00 21.46 C ATOM 6590 CD1 LEU A 922 −22.583 40.836 −51.739 1.00 22.30 C ATOM 6591 CD2 LEU A 922 −23.074 38.451 −51.255 1.00 21.41 C ATOM 6592 C LEU A 922 −26.600 40.189 −50.844 1.00 22.33 C ATOM 6593 O LEU A 922 −27.030 39.230 −50.208 1.00 22.40 O ATOM 6594 N VAL A 923 −27.015 40.506 −52.068 1.00 23.48 N ATOM 6595 CA VAL A 923 −28.078 39.783 −52.784 1.00 23.23 C ATOM 6596 CB VAL A 923 −29.214 40.737 −53.187 1.00 23.45 C ATOM 6597 CG1 VAL A 923 −30.238 40.007 −54.041 1.00 23.38 C ATOM 6598 CG2 VAL A 923 −29.853 41.363 −51.952 1.00 23.15 C ATOM 6599 C VAL A 923 −27.498 39.214 −54.063 1.00 23.21 C ATOM 6600 O VAL A 923 −26.841 39.932 −54.810 1.00 24.87 O ATOM 6601 N GLY A 924 −27.738 37.936 −54.328 1.00 22.78 N ATOM 6602 CA GLY A 924 −27.123 37.277 −55.487 1.00 21.53 C ATOM 6603 C GLY A 924 −28.006 36.210 −56.083 1.00 20.65 C ATOM 6604 O GLY A 924 −28.924 35.723 −55.422 1.00 20.93 O ATOM 6605 N ASP A 925 −27.732 35.851 −57.334 1.00 19.50 N ATOM 6606 CA ASP A 925 −28.463 34.785 −58.005 1.00 18.45 C ATOM 6607 CB ASP A 925 −29.391 35.364 −59.071 1.00 18.54 C ATOM 6608 CG ASP A 925 −28.646 35.929 −60.258 1.00 18.84 C ATOM 6609 OD1 ASP A 925 −27.428 36.197 −60.157 1.00 19.03 O ATOM 6610 OD2 ASP A 925 −29.289 36.108 −61.307 1.00 19.11 O ATOM 6611 C ASP A 925 −27.542 33.740 −58.616 1.00 17.66 C ATOM 6612 O ASP A 925 −26.331 33.910 −58.635 1.00 16.88 O ATOM 6613 N LEU A 926 −28.141 32.673 −59.143 1.00 17.72 N ATOM 6614 CA LEU A 926 −27.403 31.558 −59.733 1.00 17.53 C ATOM 6615 CB LEU A 926 −28.368 30.536 −60.329 1.00 17.45 C ATOM 6616 CG LEU A 926 −27.791 29.146 −60.649 1.00 18.04 C ATOM 6617 CD1 LEU A 926 −27.321 28.445 −59.381 1.00 18.47 C ATOM 6618 CD2 LEU A 926 −28.769 28.254 −61.406 1.00 17.82 C ATOM 6619 C LEU A 926 −26.444 32.037 −60.801 1.00 17.83 C ATOM 6620 O LEU A 926 −25.432 31.400 −61.081 1.00 18.38 O ATOM 6621 N MET A 927 −26.754 33.187 −61.371 1.00 18.34 N ATOM 6622 CA MET A 927 −26.098 33.659 −62.560 1.00 18.37 C ATOM 6623 CB MET A 927 −27.115 34.357 −63.443 1.00 19.07 C ATOM 6624 CG MET A 927 −26.752 34.314 −64.907 1.00 20.61 C ATOM 6625 SD MET A 927 −27.528 32.982 −65.827 1.00 21.69 S ATOM 6626 CE MET A 927 −26.511 33.036 −67.296 1.00 20.80 C ATOM 6627 C MET A 927 −24.945 34.589 −62.229 1.00 18.32 C ATOM 6628 O MET A 927 −24.219 35.014 −63.115 1.00 18.39 O ATOM 6629 N ARG A 928 −24.773 34.910 −60.955 1.00 18.88 N ATOM 6630 CA ARG A 928 −23.568 35.614 −60.516 1.00 19.96 C ATOM 6631 CB ARG A 928 −22.374 35.122 −61.348 1.00 20.04 C ATOM 6632 CG ARG A 928 −21.201 36.049 −61.518 1.00 21.18 C ATOM 6633 CD ARG A 928 −20.285 35.982 −60.335 1.00 21.77 C ATOM 6634 NE ARG A 928 −18.989 36.568 −60.636 1.00 23.88 N ATOM 6635 CZ ARG A 928 −18.758 37.871 −60.827 1.00 26.00 C ATOM 6636 NH1 ARG A 928 −19.753 38.772 −60.793 1.00 25.61 N ATOM 6637 NH2 ARG A 928 −17.512 38.276 −61.056 1.00 27.34 N ATOM 6638 C ARG A 928 −23.738 37.149 −60.512 1.00 20.62 C ATOM 6639 O ARG A 928 −22.797 37.914 −60.273 1.00 20.94 O ATOM 6640 N SER A 929 −24.962 37.590 −60.743 1.00 21.01 N ATOM 6641 CA SER A 929 −25.310 38.970 −60.496 1.00 21.66 C ATOM 6642 CB SER A 929 −26.672 39.277 −61.103 1.00 21.86 C ATOM 6643 OG SER A 929 −26.788 38.671 −62.378 1.00 22.71 O ATOM 6644 C SER A 929 −25.316 39.230 −58.981 1.00 22.35 C ATOM 6645 O SER A 929 −25.978 38.516 −58.211 1.00 22.31 O ATOM 6646 N VAL A 930 −24.551 40.234 −58.558 1.00 22.59 N ATOM 6647 CA VAL A 930 −24.544 40.659 −57.162 1.00 22.64 C ATOM 6648 CB VAL A 930 −23.187 40.396 −56.472 1.00 22.07 C ATOM 6649 CG1 VAL A 930 −22.788 38.936 −56.630 1.00 21.96 C ATOM 6650 CG2 VAL A 930 −22.106 41.295 −57.037 1.00 22.34 C ATOM 6651 C VAL A 930 −25.006 42.109 −56.981 1.00 23.49 C ATOM 6652 O VAL A 930 −24.750 42.991 −57.819 1.00 23.27 O ATOM 6653 N LEU A 931 −25.713 42.330 −55.882 1.00 24.46 N ATOM 6654 CA LEU A 931 −26.268 43.623 −55.538 1.00 25.20 C ATOM 6655 CB LEU A 931 −27.785 43.594 −55.687 1.00 25.68 C ATOM 6656 CG LEU A 931 −28.440 44.266 −56.886 1.00 26.44 C ATOM 6657 CD1 LEU A 931 −28.029 43.633 −58.207 1.00 27.72 C ATOM 6658 CD2 LEU A 931 −29.944 44.194 −56.712 1.00 27.28 C ATOM 6659 C LEU A 931 −25.934 43.892 −54.090 1.00 26.48 C ATOM 6660 O LEU A 931 −26.167 43.036 −53.222 1.00 27.04 O ATOM 6661 N LEU A 932 −25.378 45.071 −53.822 1.00 26.60 N ATOM 6662 CA LEU A 932 −25.193 45.509 −52.454 1.00 26.57 C ATOM 6663 CB LEU A 932 −23.833 46.193 −52.276 1.00 27.14 C ATOM 6664 CG LEU A 932 −23.375 46.330 −50.813 1.00 28.96 C ATOM 6665 CD1 LEU A 932 −23.324 44.988 −50.076 1.00 28.76 C ATOM 6666 CD2 LEU A 932 −22.040 47.049 −50.705 1.00 29.26 C ATOM 6667 C LEU A 932 −26.364 46.423 −52.056 1.00 26.31 C ATOM 6668 O LEU A 932 −26.755 47.295 −52.823 1.00 26.28 O ATOM 6669 N LEU A 933 −26.937 46.195 −50.873 1.00 25.63 N ATOM 6670 CA LEU A 933 −28.072 46.995 −50.387 1.00 24.73 C ATOM 6671 CB LEU A 933 −29.357 46.167 −50.413 1.00 24.34 C ATOM 6672 CG LEU A 933 −29.939 45.734 −51.752 1.00 23.96 C ATOM 6673 CD1 LEU A 933 −30.902 44.592 −51.512 1.00 23.57 C ATOM 6674 CD2 LEU A 933 −30.647 46.878 −52.440 1.00 24.14 C ATOM 6675 C LEU A 933 −27.860 47.552 −48.973 1.00 24.49 C ATOM 6676 O LEU A 933 −27.155 46.945 −48.152 1.00 25.10 O ATOM 6677 N ALA A 934 −28.499 48.688 −48.687 1.00 23.11 N ATOM 6678 CA ALA A 934 −28.379 49.344 −47.388 1.00 22.73 C ATOM 6679 CB ALA A 934 −27.597 50.636 −47.528 1.00 22.50 C ATOM 6680 C ALA A 934 −29.736 49.626 −46.747 1.00 23.17 C ATOM 6681 O ALA A 934 −30.504 50.463 −47.240 1.00 23.97 O ATOM 6682 N TYR A 935 −30.028 48.936 −45.645 1.00 22.76 N ATOM 6683 CA TYR A 935 −31.217 49.232 −44.873 1.00 22.22 C ATOM 6684 CB TYR A 935 −31.430 48.225 −43.750 1.00 21.84 C ATOM 6685 CG TYR A 935 −32.592 48.600 −42.859 1.00 21.26 C ATOM 6686 CD1 TYR A 935 −33.884 48.680 −43.376 1.00 21.48 C ATOM 6687 CE1 TYR A 935 −34.956 49.039 −42.584 1.00 21.38 C ATOM 6688 CZ TYR A 935 −34.749 49.320 −41.246 1.00 21.34 C ATOM 6689 OH TYR A 935 −35.829 49.677 −40.471 1.00 21.19 O ATOM 6690 CE2 TYR A 935 −33.475 49.245 −40.704 1.00 21.02 C ATOM 6691 CD2 TYR A 935 −32.403 48.893 −41.515 1.00 20.94 C ATOM 6692 C TYR A 935 −31.036 50.593 −44.262 1.00 23.03 C ATOM 6693 O TYR A 935 −30.080 50.825 −43.526 1.00 24.50 O ATOM 6694 N LYS A 936 −31.961 51.492 −44.562 1.00 23.14 N ATOM 6695 CA LYS A 936 −31.917 52.846 −44.042 1.00 22.71 C ATOM 6696 CB LYS A 936 −32.132 53.843 −45.184 1.00 23.45 C ATOM 6697 CG LYS A 936 −31.118 53.694 −46.319 1.00 23.33 C ATOM 6698 CD LYS A 936 −29.686 53.814 −45.803 1.00 23.15 C ATOM 6699 CE LYS A 936 −28.892 54.849 −46.589 1.00 22.99 C ATOM 6700 NZ LYS A 936 −29.630 56.133 −46.729 1.00 22.36 N ATOM 6701 C LYS A 936 −32.948 53.016 −42.925 1.00 22.21 C ATOM 6702 O LYS A 936 −34.135 53.198 −43.190 1.00 21.75 O ATOM 6703 N PRO A 937 −32.492 52.928 −41.663 1.00 22.32 N ATOM 6704 CA PRO A 937 −33.393 52.901 −40.515 1.00 22.69 C ATOM 6705 CB PRO A 937 −32.433 52.890 −39.319 1.00 22.54 C ATOM 6706 CG PRO A 937 −31.213 52.214 −39.841 1.00 22.25 C ATOM 6707 CD PRO A 937 −31.088 52.720 −41.254 1.00 22.34 C ATOM 6708 C PRO A 937 −34.335 54.093 −40.448 1.00 23.45 C ATOM 6709 O PRO A 937 −35.483 53.930 −40.072 1.00 24.66 O ATOM 6710 N MET A 938 −33.854 55.275 −40.819 1.00 24.67 N ATOM 6711 CA MET A 938 −34.657 56.495 −40.792 1.00 25.32 C ATOM 6712 CB MET A 938 −33.748 57.719 −40.793 1.00 25.66 C ATOM 6713 CG MET A 938 −32.969 57.932 −39.507 1.00 26.09 C ATOM 6714 SD MET A 938 −32.032 59.477 −39.564 1.00 28.44 S ATOM 6715 CE MET A 938 −30.734 59.068 −40.739 1.00 28.03 C ATOM 6716 C MET A 938 −35.638 56.577 −41.962 1.00 25.82 C ATOM 6717 O MET A 938 −36.542 57.412 −41.967 1.00 25.83 O ATOM 6718 N GLU A 939 −35.449 55.707 −42.949 1.00 27.54 N ATOM 6719 CA GLU A 939 −36.294 55.651 −44.134 1.00 28.84 C ATOM 6720 CB GLU A 939 −35.429 55.564 −45.384 1.00 32.21 C ATOM 6721 CG GLU A 939 −35.221 56.849 −46.171 1.00 36.05 C ATOM 6722 CD GLU A 939 −34.341 56.624 −47.412 1.00 40.07 C ATOM 6723 OE1 GLU A 939 −33.702 57.592 −47.887 1.00 42.86 O ATOM 6724 OE2 GLU A 939 −34.275 55.474 −47.916 1.00 40.86 O ATOM 6725 C GLU A 939 −37.246 54.452 −44.113 1.00 28.14 C ATOM 6726 O GLU A 939 −38.250 54.470 −44.806 1.00 29.23 O ATOM 6727 N GLY A 940 −36.917 53.411 −43.347 1.00 27.07 N ATOM 6728 CA GLY A 940 −37.735 52.188 −43.264 1.00 27.09 C ATOM 6729 C GLY A 940 −37.777 51.439 −44.582 1.00 27.90 C ATOM 6730 O GLY A 940 −38.832 50.989 −45.026 1.00 27.05 O ATOM 6731 N ASN A 941 −36.600 51.244 −45.160 1.00 29.83 N ATOM 6732 CA ASN A 941 −36.436 51.240 −46.599 1.00 30.69 C ATOM 6733 CB ASN A 941 −36.381 52.698 −47.034 1.00 34.15 C ATOM 6734 CG ASN A 941 −37.044 52.941 −48.357 1.00 37.19 C ATOM 6735 OD1 ASN A 941 −37.507 52.005 −49.013 1.00 41.81 O ATOM 6736 ND2 ASN A 941 −37.101 54.210 −48.765 1.00 36.07 N ATOM 6737 C ASN A 941 −35.120 50.613 −46.996 1.00 29.48 C ATOM 6738 O ASN A 941 −34.217 50.504 −46.182 1.00 30.19 O ATOM 6739 N PHE A 942 −34.995 50.222 −48.255 1.00 28.70 N ATOM 6740 CA PHE A 942 −33.703 49.772 −48.773 1.00 28.48 C ATOM 6741 CB PHE A 942 −33.803 48.388 −49.414 1.00 28.27 C ATOM 6742 CG PHE A 942 −34.078 47.289 −48.440 1.00 27.77 C ATOM 6743 CD1 PHE A 942 −33.126 46.921 −47.504 1.00 28.16 C ATOM 6744 CE1 PHE A 942 −33.377 45.899 −46.601 1.00 28.68 C ATOM 6745 CZ PHE A 942 −34.586 45.227 −49.635 1.00 28.53 C ATOM 6746 CE2 PHE A 942 −35.540 45.584 −47.574 1.00 28.49 C ATOM 6747 CD2 PHE A 942 −35.284 46.610 −48.469 1.00 27.76 C ATOM 6748 C PHE A 942 −33.166 50.751 −49.788 1.00 28.04 C ATOM 6749 O PHE A 942 −33.914 51.545 −50.346 1.00 29.19 O ATOM 6750 N GLU A 943 −31.865 50.680 −50.023 1.00 28.27 N ATOM 6751 CA GLU A 943 −31.195 51.536 −50.989 1.00 29.79 C ATOM 6752 CB GLU A 943 −30.579 52.722 −50.253 1.00 30.41 C ATOM 6753 CG GLU A 943 −29.990 53.810 −51.123 1.00 32.01 C ATOM 6754 CD GLU A 943 −29.054 54.720 −50.338 1.00 34.90 C ATOM 6755 OE1 GLU A 943 −28.136 54.200 −49.661 1.00 35.66 O ATOM 6756 OE2 GLU A 943 −29.224 55.961 −50.393 1.00 36.77 O ATOM 6757 C GLU A 943 −30.111 50.699 −51.668 1.00 30.23 C ATOM 6758 O GLU A 943 −29.282 50.107 −50.978 1.00 31.09 O ATOM 6759 N GLU A 944 −30.134 50.604 −53.001 1.00 29.96 N ATOM 6760 CA GLU A 944 −29.090 49.855 −53.715 1.00 29.58 C ATOM 6761 CB GLU A 944 −29.546 49.347 −55.093 1.00 32.65 C ATOM 6762 CG GLU A 944 −30.490 50.270 −55.860 1.00 37.83 C ATOM 6763 CD GLU A 944 −31.437 49.516 −56.799 1.00 40.89 C ATOM 6764 OE1 GLU A 944 −31.033 48.455 −57.352 1.00 44.05 O ATOM 6765 OE2 GLU A 944 −32.590 49.988 −56.983 1.00 39.42 O ATOM 6766 C GLU A 944 −27.829 50.680 −53.809 1.00 27.24 C ATOM 6767 O GLU A 944 −27.869 51.816 −54.248 1.00 27.45 O ATOM 6768 N ILE A 945 −26.722 50.097 −53.363 1.00 25.34 N ATOM 6769 CA ILE A 945 −25.448 50.793 −53.213 1.00 24.83 C ATOM 6770 CB ILE A 945 −24.723 50.360 −51.912 1.00 24.93 C ATOM 6771 CG1 ILE A 945 −25.575 50.685 −50.680 1.00 24.76 C ATOM 6772 CD1 ILE A 945 −26.262 52.037 −50.728 1.00 24.36 C ATOM 6773 CG2 ILE A 945 −23.337 50.994 −51.803 1.00 24.67 C ATOM 6774 C ILE A 945 −24.538 50.526 −54.406 1.00 24.45 C ATOM 6775 O ILE A 945 −24.013 51.461 −55.020 1.00 23.81 O ATOM 6776 N ALA A 946 −24.346 49.243 −54.708 1.00 24.31 N ATOM 6777 CA ALA A 946 −23.527 48.812 −55.832 1.00 24.15 C ATOM 6778 CB ALA A 946 −22.112 48.506 −55.380 1.00 22.95 C ATOM 6779 C ALA A 946 −24.142 47.610 −56.512 1.00 23.68 C ATOM 6780 O ALA A 946 −25.081 47.024 −56.015 1.00 23.04 O ATOM 6781 N ARG A 947 −23.577 47.228 −57.641 1.00 25.66 N ATOM 6782 CA ARG A 947 −24.206 46.277 −58.527 1.00 28.28 C ATOM 6783 CB ARG A 947 −25.339 46.997 −59.271 1.00 29.13 C ATOM 6784 CG ARG A 947 −25.768 46.398 −60.594 1.00 30.25 C ATOM 6785 CD ARG A 947 −26.981 47.123 −61.145 1.00 30.68 C ATOM 6786 NE ARG A 947 −28.212 46.614 −60.552 1.00 31.87 N ATOM 6787 CZ ARG A 947 −29.401 46.615 −61.153 1.00 32.55 C ATOM 6788 NH1 ARG A 947 −29.540 47.101 −62.386 1.00 32.31 N ATOM 6789 NH2 ARG A 947 −30.459 46.120 −60.517 1.00 33.09 N ATOM 6790 C ARG A 947 −23.150 45.766 −59.495 1.00 30.36 C ATOM 6791 O ARG A 947 −22.247 46.508 −59.878 1.00 31.84 O ATOM 6792 N ASP A 948 −23.241 44.497 −59.872 1.00 32.63 N ATOM 6793 CA ASP A 948 −22.357 43.960 −60.900 1.00 34.07 C ATOM 6794 CB ASP A 948 −21.032 43.530 −60.299 1.00 35.05 C ATOM 6795 CG ASP A 948 −20.007 43.199 −61.353 1.00 38.19 C ATOM 6796 OD1 ASP A 948 −20.155 43.663 −62.514 1.00 38.25 O ATOM 6797 OD2 ASP A 948 −19.046 42.474 −61.019 1.00 40.73 O ATOM 6798 C ASP A 948 −22.972 42.791 −61.644 1.00 35.34 C ATOM 6799 O ASP A 948 −23.247 41.755 −61.054 1.00 38.44 O ATOM 6800 N PHE A 949 −23.163 42.949 −62.947 1.00 35.40 N ATOM 6801 CA PHE A 949 −23.783 41.908 −63.754 1.00 34.37 C ATOM 6802 CB PHE A 949 −24.966 42.470 −64.553 1.00 36.98 C ATOM 6803 CG PHE A 949 −26.232 42.587 −63.754 1.00 39.96 C ATOM 6804 CD1 PHE A 949 −26.329 43.490 −62.690 1.00 41.30 C ATOM 6805 CE1 PHE A 949 −27.498 43.591 −61.942 1.00 41.22 C ATOM 6806 CZ PHE A 949 −28.590 42.796 −62.258 1.00 41.28 C ATOM 6807 CE2 PHE A 949 −28.508 41.898 −63.319 1.00 41.45 C ATOM 6808 CD2 PHE A 949 −27.335 41.796 −64.060 1.00 41.23 C ATOM 6809 C PHE A 949 −22.759 41.274 −64.677 1.00 32.31 C ATOM 6810 O PHE A 949 −22.621 41.669 −65.829 1.00 35.79 O ATOM 6811 N ASN A 950 −22.048 40.283 −64.161 1.00 28.49 N ATOM 6812 CA ASN A 950 −21.034 39.576 −64.924 1.00 26.20 C ATOM 6813 CB ASN A 950 −19.669 39.843 −64.305 1.00 25.65 C ATOM 6814 CG ASN A 950 −18.537 39.343 −65.150 1.00 24.84 C ATOM 6815 OD1 ASN A 950 −17.396 39.715 −64.925 1.00 25.34 O ATOM 6816 ND2 ASN A 950 −18.838 38.498 −66.128 1.00 24.40 N ATOM 6817 C ASN A 950 −21.332 38.071 −64.975 1.00 24.85 C ATOM 6818 O ASN A 950 −20.913 37.314 −64.109 1.00 25.87 O ATOM 6819 N PRO A 951 −22.018 37.631 −66.022 1.00 23.18 N ATOM 6820 CA PRO A 951 −22.725 36.356 −66.023 1.00 22.24 C ATOM 6821 CB PRO A 951 −23.494 36.388 −67.358 1.00 23.09 C ATOM 6822 CG PRO A 951 −23.331 37.772 −67.908 1.00 22.64 C ATOM 6823 CD PRO A 951 −22.054 38.281 −67.337 1.00 22.82 C ATOM 6824 C PRO A 951 −21.864 35.087 −65.951 1.00 21.01 C ATOM 6825 O PRO A 951 −21.310 34.664 −66.956 1.00 21.07 O ATOM 6826 N ASN A 952 −21.798 34.468 −64.776 1.00 20.03 N ATOM 6827 CA ASN A 952 −21.258 33.102 −64.624 1.00 18.90 C ATOM 6828 CB ASN A 952 −19.796 33.169 −64.190 1.00 18.81 C ATOM 6829 CG ASN A 952 −19.032 31.900 −64.505 1.00 18.94 C ATOM 6830 OD1 ASN A 952 −19.384 31.160 −65.424 1.00 19.17 O ATOM 6831 ND2 ASN A 952 −17.967 31.650 −63.757 1.00 18.75 N ATOM 6832 C ASN A 952 −22.069 32.308 −63.593 1.00 18.00 C ATOM 6833 O ASN A 952 −22.599 32.898 −62.672 1.00 18.28 O ATOM 6834 N TRP A 953 −22.182 30.988 −63.734 1.00 17.13 N ATOM 6835 CA TRP A 953 −22.813 30.173 −62.670 1.00 16.35 C ATOM 6836 CB TRP A 953 −22.704 28.679 −62.956 1.00 16.51 C ATOM 6837 CG TRP A 953 −23.293 28.266 −64.260 1.00 16.65 C ATOM 6838 CD1 TRP A 953 −22.710 27.477 −65.240 1.00 16.64 C ATOM 6839 NE1 TRP A 953 −23.555 27.337 −66.320 1.00 17.21 N ATOM 6840 CE2 TRP A 953 −24.710 28.017 −66.114 1.00 17.23 C ATOM 6841 CD2 TRP A 953 −24.607 28.649 −64.797 1.00 17.33 C ATOM 6842 CE3 TRP A 953 −25.671 29.441 −64.333 1.00 17.03 C ATOM 6843 CZ3 TRP A 953 −26.787 29.593 −65.149 1.00 16.90 C ATOM 6844 CH2 TRP A 953 −26.864 28.972 −66.409 1.00 17.16 C ATOM 6845 CZ2 TRP A 953 −25.827 28.170 −66.911 1.00 17.21 C ATOM 6846 C TRP A 953 −22.130 30.446 −61.377 1.00 16.09 C ATOM 6847 O TRP A 953 −20.907 30.351 −61.298 1.00 16.48 O ATOM 6848 N MET A 954 −22.898 30.786 −60.348 1.00 15.42 N ATOM 6849 CA MET A 954 −22.338 31.085 −59.034 1.00 14.79 C ATOM 6850 CB MET A 954 −22.587 32.543 −58.681 1.00 15.51 C ATOM 6851 CG MET A 954 −22.050 32.961 −57.320 1.00 16.55 C ATOM 6852 SD MET A 954 −22.202 34.723 −56.965 1.00 17.23 S ATOM 6853 CE MET A 954 −23.900 34.829 −56.419 1.00 17.22 C ATOM 6854 C MET A 954 −22.986 30.181 −58.003 1.00 14.29 C ATOM 6855 O MET A 954 −24.206 30.014 −58.021 1.00 14.53 O ATOM 6856 N SER A 955 −22.184 29.627 −57.088 1.00 13.42 N ATOM 6857 CA SER A 955 −22.657 28.568 −56.188 1.00 12.67 C ATOM 6858 CB SER A 955 −21.810 27.318 −56.364 1.00 12.33 C ATOM 6859 OG SER A 955 −20.510 27.499 −55.846 1.00 12.20 O ATOM 6860 C SER A 955 −22.747 28.915 −54.706 1.00 12.55 C ATOM 6861 O SER A 955 −23.382 28.193 −53.932 1.00 12.48 O ATOM 6862 N ALA A 956 −22.126 30.022 −54.315 1.00 12.71 N ATOM 6863 CA ALA A 956 −21.998 30.392 −52.903 1.00 13.19 C ATOM 6864 CB ALA A 956 −21.110 29.387 −52.170 1.00 12.88 C ATOM 6865 C ALA A 956 −21.387 31.784 −52.820 1.00 13.75 C ATOM 6866 O ALA A 956 −20.524 32.120 −53.624 1.00 14.46 O ATOM 6867 N VAL A 957 −21.834 32.596 −51.865 1.00 14.16 N ATOM 6868 CA VAL A 957 −21.198 33.883 −51.593 1.00 14.52 C ATOM 6869 CB VAL A 957 −21.952 35.086 −52.201 1.00 14.45 C ATOM 6870 CG1 VAL A 957 −21.527 35.332 −53.629 1.00 14.51 C ATOM 6871 CG2 VAL A 957 −23.452 34.909 −52.108 1.00 14.56 C ATOM 6872 C VAL A 957 −21.045 34.121 −50.104 1.00 15.29 C ATOM 6873 O VAL A 957 −21.762 33.539 −49.296 1.00 15.11 O ATOM 6874 N GLU A 958 −20.101 34.987 −49.750 1.00 16.68 N ATOM 6875 CA GLU A 958 −19.910 35.416 −48.368 1.00 17.64 C ATOM 6876 CB GLU A 958 −18.928 34.464 −47.663 1.00 18.77 C ATOM 6877 CG GLU A 958 −18.753 34.685 −46.168 1.00 20.40 C ATOM 6878 CD GLU A 958 −20.070 34.661 −45.416 1.00 22.43 C ATOM 6879 OE1 GLU A 958 −20.768 35.707 −45.382 1.00 23.45 O ATOM 6880 OE2 GLU A 958 −20.403 33.598 −44.845 1.00 23.72 O ATOM 6881 C GLU A 958 −19.406 36.867 −48.318 1.00 17.46 C ATOM 6882 O GLU A 958 −18.697 37.314 −49.220 1.00 17.47 O ATOM 6883 N ILE A 959 −19.766 37.598 −47.270 1.00 17.26 N ATOM 6884 CA ILE A 959 −19.159 38.906 −47.031 1.00 17.62 C ATOM 6885 CB ILE A 959 −20.129 39.859 −46.307 1.00 17.18 C ATOM 6886 CG1 ILE A 959 −21.294 40.223 −47.225 1.00 17.01 C ATOM 6887 CD1 ILE A 959 −22.568 40.548 −46.480 1.00 16.69 C ATOM 6888 CG2 ILE A 959 −19.412 41.109 −45.820 1.00 17.03 C ATOM 6889 C ILE A 959 −17.862 38.759 −46.237 1.00 18.38 C ATOM 6890 O ILE A 959 −17.842 38.139 −45.172 1.00 18.29 O ATOM 6891 N LEU A 960 −16.780 39.327 −46.762 1.00 19.76 N ATOM 6892 CA LEU A 960 −15.497 39.311 −46.067 1.00 21.31 C ATOM 6893 CB LEU A 960 −14.336 39.353 −47.057 1.00 20.27 C ATOM 6894 CG LEU A 960 −14.258 38.145 −48.012 1.00 20.65 C ATOM 6895 CD1 LEU A 960 −13.410 38.450 −49.247 1.00 20.78 C ATOM 6896 CD2 LEU A 960 −13.799 36.858 −47.334 1.00 19.82 C ATOM 6897 C LEU A 960 −15.421 40.460 −45.071 1.00 23.67 C ATOM 6898 O LEU A 960 −15.059 40.264 −43.905 1.00 24.12 O ATOM 6899 N ASP A 961 −15.779 41.652 −45.544 1.00 26.36 N ATOM 6900 CA ASP A 961 −15.912 42.850 −44.710 1.00 29.29 C ATOM 6901 CB ASP A 961 −14.539 43.408 −44.329 1.00 28.44 C ATOM 6902 CG ASP A 961 −13.719 43.821 −45.528 1.00 28.29 C ATOM 6903 OD1 ASP A 961 −14.289 44.231 −46.559 1.00 28.05 O ATOM 6904 OD2 ASP A 961 −12.482 43.745 −45.431 1.00 30.07 O ATOM 6905 C ASP A 961 −16.755 43.911 −45.437 1.00 32.84 C ATOM 6906 O ASP A 961 −17.248 43.671 −46.545 1.00 33.42 O ATOM 6907 N ASP A 962 −16.904 45.086 −44.830 1.00 37.38 N ATOM 6908 CA ASP A 962 −17.824 46.104 −45.350 1.00 41.78 C ATOM 6909 CB ASP A 962 −17.621 47.446 −44.632 1.00 47.69 C ATOM 6910 CG ASP A 962 −17.996 47.390 −43.159 1.00 52.16 C ATOM 6911 OD1 ASP A 962 −19.082 46.857 −42.841 1.00 55.78 O ATOM 6912 OD2 ASP A 962 −17.207 47.889 −42.321 1.00 55.28 O ATOM 6913 C ASP A 962 −17.695 46.306 −46.860 1.00 41.28 C ATOM 6914 O ASP A 962 −18.670 46.686 −47.528 1.00 42.72 O ATOM 6915 N ASP A 963 −16.498 46.037 −47.386 1.00 37.28 N ATOM 6916 CA ASP A 963 −16.142 46.430 −48.741 1.00 35.39 C ATOM 6917 CB ASP A 963 −14.945 47.381 −48.695 1.00 37.38 C ATOM 6918 CG ASP A 963 −15.293 48.748 −48.096 1.00 40.19 C ATOM 6919 OD1 ASP A 963 −16.415 48.930 −47.558 1.00 39.44 O ATOM 6920 OD2 ASP A 963 −14.428 49.653 −48.172 1.00 42.07 O ATOM 6921 C ASP A 963 −15.844 45.268 −49.691 1.00 33.05 C ATOM 6922 O ASP A 963 −15.689 45.476 −50.891 1.00 33.27 O ATOM 6923 N ASN A 964 −15.775 44.051 −49.161 1.00 30.23 N ATOM 6924 CA ASN A 964 −15.324 42.895 −49.938 1.00 27.04 C ATOM 6925 CB ASN A 964 −13.904 42.509 −49.531 1.00 26.79 C ATOM 6926 CG ASN A 964 −12.889 43.553 −49.926 1.00 27.11 C ATOM 6927 OD1 ASN A 964 −12.423 43.590 −51.063 1.00 26.37 O ATOM 6928 ND2 ASN A 964 −12.541 44.414 −48.985 1.00 28.41 N ATOM 6929 C ASN A 964 −16.238 41.680 −49.847 1.00 25.01 C ATOM 6930 O ASN A 964 −16.671 41.304 −48.759 1.00 23.81 O ATOM 6931 N PHE A 965 −16.504 41.068 −51.003 1.00 23.74 N ATOM 6932 CA PHE A 965 −17.397 39.911 −51.112 1.00 22.39 C ATOM 6933 CB PHE A 965 −18.699 40.322 −51.793 1.00 23.12 C ATOM 6934 CG PHE A 965 −19.157 41.668 −51.369 1.00 25.54 C ATOM 6935 CD1 PHE A 965 −19.563 41.895 −50.049 1.00 26.63 C ATOM 6936 CE1 PHE A 965 −19.939 43.166 −49.619 1.00 27.30 C ATOM 6937 CZ PHE A 965 −19.891 44.229 −50.504 1.00 27.51 C ATOM 6938 CE2 PHE A 965 −19.469 44.021 −51.813 1.00 28.00 C ATOM 6939 CD2 PHE A 965 −19.093 42.745 −52.239 1.00 27.17 C ATOM 6940 C PHE A 965 −16.733 38.734 −51.813 1.00 21.25 C ATOM 6941 O PHE A 965 −16.151 38.871 −52.885 1.00 20.88 O ATOM 6942 N LEU A 966 −16.793 37.581 −51.165 1.00 19.92 N ATOM 6943 CA LEU A 966 −16.251 36.352 −51.715 1.00 19.36 C ATOM 6944 CB LEU A 966 −15.593 35.536 −50.594 1.00 18.94 C ATOM 6945 CG LEU A 966 −14.939 34.175 −50.850 1.00 18.35 C ATOM 6946 CD1 LEU A 966 −13.694 34.333 −51.706 1.00 18.03 C ATOM 6947 CD2 LEU A 966 −14.609 33.500 −49.522 1.00 17.68 C ATOM 6948 C LEU A 966 −17.371 35.551 −52.399 1.00 17.00 C ATOM 6949 O LEU A 966 −18.534 35.601 −51.988 1.00 18.59 O ATOM 6950 N GLY A 967 −17.014 34.831 −53.454 1.00 18.15 N ATOM 6951 CA GLY A 967 −17.979 34.051 −54.191 1.00 17.47 C ATOM 6952 C GLY A 967 −17.282 32.907 −54.875 1.00 17.97 C ATOM 6953 O GLY A 967 −16.090 33.009 −55.228 1.00 18.24 O ATOM 6954 N ALA A 968 −18.006 31.800 −55.039 1.00 17.44 N ATOM 6955 CA ALA A 968 −17.522 30.679 −55.828 1.00 16.50 C ATOM 6956 CB ALA A 968 −17.704 29.385 −55.069 1.00 16.12 C ATOM 6957 C ALA A 968 −18.293 30.659 −57.138 1.00 16.33 C ATOM 6958 O ALA A 968 −19.509 30.834 −57.146 1.00 15.94 O ATOM 6959 N GLU A 969 −17.578 30.477 −58.243 1.00 16.45 N ATOM 6960 CA GLU A 969 −18.173 30.604 −59.567 1.00 17.06 C ATOM 6961 CB GLU A 969 −18.087 32.049 −60.075 1.00 17.66 C ATOM 6962 CG GLU A 969 −16.715 32.440 −60.581 1.00 19.21 C ATOM 6963 CD GLU A 969 −16.730 33.753 −61.331 1.00 21.25 C ATOM 6964 OE1 GLU A 969 −17.526 33.887 −62.285 1.00 23.17 O ATOM 6965 OE2 GLU A 969 −15.944 34.661 −60.979 1.00 22.19 O ATOM 6966 C GLU A 969 −17.584 29.626 −60.589 1.00 16.72 C ATOM 6967 O GLU A 969 −16.528 29.054 −60.380 1.00 16.82 O ATOM 6968 N ASN A 970 −18.261 29.495 −61.721 1.00 16.53 N ATOM 6969 CA ASN A 970 −18.125 28.327 −62.571 1.00 16.26 C ATOM 6970 CB ASN A 970 −19.012 28.421 −63.801 1.00 16.41 C ATOM 6971 CG ASN A 970 −18.720 27.320 −64.795 1.00 15.70 C ATOM 6972 OD1 ASN A 970 −19.137 26.166 −64.609 1.00 14.95 O ATOM 6973 ND2 ASN A 970 −17.957 27.659 −65.833 1.00 15.35 N ATOM 6974 C ASN A 970 −16.750 27.947 −63.028 1.00 16.12 C ATOM 6975 O ASN A 970 −15.956 28.793 −63.443 1.00 15.97 O ATOM 6976 N ALA A 971 −16.565 26.625 −63.063 1.00 16.22 N ATOM 6977 CA ALA A 971 −15.301 25.933 −63.313 1.00 15.20 C ATOM 6978 CB ALA A 971 −14.630 26.415 −64.587 1.00 14.98 C ATOM 6979 C ALA A 971 −14.421 26.102 −62.072 1.00 14.81 C ATOM 6980 O ALA A 971 −13.229 26.453 −62.164 1.00 14.85 O ATOM 6981 N PHE A 972 −15.054 25.886 −60.911 1.00 13.69 N ATOM 6982 CA PHE A 972 −14.353 25.702 −59.653 1.00 13.44 C ATOM 6983 CB PHE A 972 −13.558 24.385 −59.700 1.00 13.44 C ATOM 6984 CG PHE A 972 −14.306 23.259 −60.356 1.00 13.59 C ATOM 6985 CD1 PHE A 972 −15.323 22.578 −59.670 1.00 13.71 C ATOM 6986 CE1 PHE A 972 −16.032 21.556 −60.293 1.00 13.50 C ATOM 6987 CZ PHE A 972 −15.737 21.211 −61.604 1.00 13.12 C ATOM 6988 CE2 PHE A 972 −14.742 21.876 −62.290 1.00 13.01 C ATOM 6989 CD2 PHE A 972 −14.030 22.892 −61.671 1.00 13.29 C ATOM 6990 C PHE A 972 −13.446 26.878 −59.308 1.00 13.44 C ATOM 6991 O PHE A 972 −12.290 26.691 −58.896 1.00 13.68 O ATOM 6992 N ASN A 973 −13.966 28.089 −59.483 1.00 13.14 N ATOM 6993 CA ASN A 973 −13.190 29.297 −59.263 1.00 13.46 C ATOM 6994 CB ASN A 973 −13.321 30.230 −60.462 1.00 13.58 C ATOM 6995 CG ASN A 973 −12.662 29.685 −61.701 1.00 13.45 C ATOM 6996 OD1 ASN A 973 −11.444 29.590 −61.777 1.00 13.51 O ATOM 6997 ND2 ASN A 973 −13.467 29.342 −62.690 1.00 13.54 N ATOM 6998 C ASN A 973 −13.644 30.039 −58.028 1.00 13.80 C ATOM 6999 O ASN A 973 −14.777 29.867 −57.585 1.00 14.14 O ATOM 7000 N LEU A 974 −12.766 30.870 −57.475 1.00 14.33 N ATOM 7001 CA LEU A 974 −13.169 31.851 −56.467 1.00 15.24 C ATOM 7002 CB LEU A 974 −12.382 31.676 −55.170 1.00 14.97 C ATOM 7003 CG LEU A 974 −12.587 30.411 −54.325 1.00 15.19 C ATOM 7004 CD1 LEU A 974 −11.813 30.583 −53.034 1.00 15.68 C ATOM 7005 CD2 LEU A 974 −14.041 30.123 −53.986 1.00 15.10 C ATOM 7006 C LEU A 974 −12.942 33.248 −57.007 1.00 16.18 C ATOM 7007 O LEU A 974 −11.934 33.501 −57.673 1.00 16.91 O ATOM 7008 N PHE A 975 −13.880 34.154 −56.733 1.00 16.84 N ATOM 7009 CA PHE A 975 −13.703 35.579 −57.048 1.00 16.66 C ATOM 7010 CB PHE A 975 −14.609 35.977 −58.204 1.00 16.45 C ATOM 7011 CG PHE A 975 −16.058 36.067 −57.830 1.00 16.23 C ATOM 7012 CD1 PHE A 975 −16.845 34.924 −57.767 1.00 15.96 C ATOM 7013 CE1 PHE A 975 −18.176 35.001 −57.413 1.00 15.74 C ATOM 7014 CZ PHE A 975 −18.735 36.230 −57.125 1.00 16.01 C ATOM 7015 CE2 PHE A 975 −17.963 37.381 −57.178 1.00 16.00 C ATOM 7016 CD2 PHE A 975 −16.635 37.298 −57.532 1.00 16.06 C ATOM 7017 C PHE A 975 −13.967 36.477 −55.839 1.00 17.04 C ATOM 7018 O PHE A 975 −14.696 36.108 −54.919 1.00 16.74 O ATOM 7019 N VAL A 976 −13.370 37.659 −55.843 1.00 18.62 N ATOM 7020 CA VAL A 976 −13.620 38.645 −54.786 1.00 20.31 C ATOM 7021 CB VAL A 976 −12.424 38.798 −53.826 1.00 19.18 C ATOM 7022 CG1 VAL A 976 −12.669 39.930 −52.857 1.00 19.25 C ATOM 7023 CG2 VAL A 976 −12.194 37.516 −53.053 1.00 18.93 C ATOM 7024 C VAL A 976 −13.977 39.992 −55.397 1.00 22.40 C ATOM 7025 O VAL A 976 −13.220 40.519 −56.206 1.00 22.82 O ATOM 7026 N CYS A 977 −15.145 40.523 −55.015 1.00 25.58 N ATOM 7027 CA CYS A 977 −15.614 41.857 −55.435 1.00 27.37 C ATOM 7028 CB CYS A 977 −17.094 41.831 −55.771 1.00 29.74 C ATOM 7029 SG CYS A 977 −17.455 41.015 −57.328 1.00 37.92 S ATOM 7030 C CYS A 977 −15.396 42.886 −54.347 1.00 27.13 C ATOM 7031 O CYS A 977 −15.599 42.602 −53.160 1.00 25.64 O ATOM 7032 N GLN A 978 −15.009 44.089 −54.766 1.00 27.34 N ATOM 7033 CA GLN A 978 −14.658 45.154 −53.839 1.00 28.01 C ATOM 7034 CB GLN A 978 −13.196 45.519 −54.010 1.00 27.04 C ATOM 7035 CG GLN A 978 −12.688 46.464 −52.951 1.00 27.17 C ATOM 7036 CD GLN A 978 −11.200 46.379 −52.792 1.00 27.25 C ATOM 7037 OE1 GLN A 978 −10.444 47.017 −53.533 1.00 27.30 O ATOM 7038 NE2 GLN A 978 −10.758 45.592 −51.811 1.00 27.46 N ATOM 7039 C GLN A 978 −15.518 46.375 −54.064 1.00 29.10 C ATOM 7040 O GLN A 978 −15.728 46.774 −55.209 1.00 30.07 O ATOM 7041 N LYS A 979 −15.997 46.982 −52.980 1.00 31.40 N ATOM 7042 CA LYS A 979 −16.932 48.105 −53.098 1.00 35.73 C ATOM 7043 CB LYS A 979 −17.533 48.521 −51.755 1.00 35.66 C ATOM 7044 CG LYS A 979 −18.562 49.638 −51.887 1.00 34.94 C ATOM 7045 CD LYS A 979 −19.457 49.731 −50.663 1.00 36.72 C ATOM 7046 CE LYS A 979 −18.733 50.314 −49.458 1.00 38.29 C ATOM 7047 NZ LYS A 979 −19.157 49.613 −48.215 1.00 39.80 N ATOM 7048 C LYS A 979 −16.322 49.306 −53.791 1.00 38.84 C ATOM 7049 O LYS A 979 −16.877 49.793 −54.778 1.00 40.20 O ATOM 7050 N ASP A 980 −15.187 49.780 −53.280 1.00 42.54 N ATOM 7051 CA ASP A 980 −14.507 50.920 −53.895 1.00 47.50 C ATOM 7052 CB ASP A 980 −13.518 51.577 −52.921 1.00 50.94 C ATOM 7053 CG ASP A 980 −12.902 52.850 −53.486 1.00 51.41 C ATOM 7054 OD1 ASP A 980 −13.617 53.596 −54.192 1.00 51.63 O ATOM 7055 OD2 ASP A 980 −11.702 53.096 −53.234 1.00 51.75 O ATOM 7056 C ASP A 980 −13.806 50.525 −55.199 1.00 47.76 C ATOM 7057 O ASP A 980 −14.082 51.098 −56.256 1.00 47.25 O ATOM 7058 N GLU A 987 −22.391 59.114 −57.781 1.00 50.94 N ATOM 7059 CA GLU A 987 −21.253 58.695 −58.598 1.00 53.30 C ATOM 7060 CB GLU A 987 −19.967 58.684 −57.741 1.00 50.19 C ATOM 7061 CG GLU A 987 −18.685 58.279 −58.469 1.00 48.14 C ATOM 7062 CD GLU A 987 −18.003 59.425 −59.202 1.00 46.73 C ATOM 7063 OE1 GLU A 987 −17.170 60.121 −58.576 1.00 44.82 O ATOM 7064 OE2 GLU A 987 −18.277 59.606 −60.410 1.00 44.01 O ATOM 7065 C GLU A 987 −21.516 57.317 −59.232 1.00 54.62 C ATOM 7066 O GLU A 987 −22.473 56.633 −58.865 1.00 52.82 O ATOM 7067 N GLU A 988 −20.699 56.949 −60.220 1.00 59.20 N ATOM 7068 CA GLU A 988 −20.551 55.547 −60.627 1.00 61.23 C ATOM 7069 CB GLU A 988 −20.503 55.355 −62.153 1.00 65.99 C ATOM 7070 CG GLU A 988 −19.953 56.529 −62.957 1.00 71.51 C ATOM 7071 CD GLU A 988 −21.040 57.488 −63.423 1.00 73.08 C ATOM 7072 OE1 GLU A 988 −21.855 57.935 −62.580 1.00 74.74 O ATOM 7073 OE2 GLU A 988 −21.074 57.801 −64.636 1.00 71.07 O ATOM 7074 C GLU A 988 −19.333 54.944 −59.928 1.00 58.79 C ATOM 7075 O GLU A 988 −18.178 55.235 −60.252 1.00 57.68 O ATOM 7076 N ARG A 989 −19.657 54.055 −58.997 1.00 57.25 N ATOM 7077 CA ARG A 989 −18.866 53.650 −57.828 1.00 54.18 C ATOM 7078 CB ARG A 989 −18.313 54.848 −57.039 1.00 54.68 C ATOM 7079 CG ARG A 989 −16.973 55.371 −57.567 1.00 57.70 C ATOM 7080 CD ARG A 989 −15.827 55.353 −56.552 1.00 58.41 C ATOM 7081 NE ARG A 989 −15.817 56.545 −55.688 1.00 56.87 N ATOM 7082 CZ ARG A 989 −14.726 57.114 −55.170 1.00 54.65 C ATOM 7083 NH1 ARG A 989 −13.516 56.627 −55.427 1.00 54.41 N ATOM 7084 NH2 ARG A 989 −14.847 58.183 −54.395 1.00 52.34 N ATOM 7085 C ARG A 989 −19.977 52.911 −57.068 1.00 50.71 C ATOM 7086 O ARG A 989 −19.809 52.414 −55.946 1.00 48.06 O ATOM 7087 N GLN A 990 −21.139 52.912 −57.728 1.00 46.34 N ATOM 7088 CA GLN A 990 −22.150 51.876 −57.636 1.00 43.05 C ATOM 7089 CB GLN A 990 −23.452 52.373 −58.261 1.00 42.71 C ATOM 7090 CG GLN A 990 −23.868 53.774 −57.847 1.00 44.27 C ATOM 7091 CD GLN A 990 −24.955 54.353 −58.732 1.00 43.49 C ATOM 7092 OE1 GLN A 990 −25.163 53.900 −59.856 1.00 44.09 O ATOM 7093 NE2 GLN A 990 −25.649 55.364 −58.231 1.00 42.99 N ATOM 7094 C GLN A 990 −21.668 50.657 −58.432 1.00 42.42 C ATOM 7095 O GLN A 990 −22.410 49.697 −58.642 1.00 40.42 O ATOM 7096 N HIS A 991 −20.424 50.720 −58.897 1.00 44.01 N ATOM 7097 CA HIS A 991 −19.834 49.652 −59.681 1.00 43.53 C ATOM 7098 CB HIS A 991 −19.163 50.216 −60.939 1.00 52.55 C ATOM 7099 CG HIS A 991 −18.509 49.159 −61.811 1.00 61.81 C ATOM 7100 ND1 HIS A 991 −19.218 48.354 −62.635 1.00 63.55 N ATOM 7101 CE1 HIS A 991 −18.376 47.511 −63.269 1.00 65.96 C ATOM 7102 NE2 HIS A 991 −17.122 47.778 −62.853 1.00 67.19 N ATOM 7103 CD2 HIS A 991 −17.166 48.785 −61.953 1.00 64.96 C ATOM 7104 C HIS A 991 −18.854 48.891 −58.850 1.00 37.28 C ATOM 7105 O HIS A 991 −17.961 49.476 −58.245 1.00 35.32 O ATOM 7106 N LEU A 992 −19.018 47.575 −58.810 1.00 32.54 N ATOM 7107 CA LEU A 992 −18.117 46.718 −58.043 1.00 30.74 C ATOM 7108 CB LEU A 992 −18.873 45.527 −57.447 1.00 28.09 C ATOM 7109 CG LEU A 992 −19.900 45.838 −56.356 1.00 27.16 C ATOM 7110 CD1 LEU A 992 −20.564 44.567 −55.855 1.00 26.90 C ATOM 7111 CD2 LEU A 992 −19.284 46.593 −55.191 1.00 26.51 C ATOM 7112 C LEU A 992 −16.912 46.247 −58.867 1.00 30.25 C ATOM 7113 O LEU A 992 −17.049 45.878 −60.036 1.00 30.30 O ATOM 7114 N GLN A 993 −15.737 46.266 −58.246 1.00 30.06 N ATOM 7115 CA GLN A 993 −14.495 45.924 −58.931 1.00 30.79 C ATOM 7116 CB GLN A 993 −13.422 46.974 −58.637 1.00 34.35 C ATOM 7117 CG GLN A 993 −13.506 48.210 −59.526 1.00 38.35 C ATOM 7118 CD GLN A 993 −12.700 48.058 −60.803 1.00 41.94 C ATOM 7119 OE1 GLN A 993 −11.467 47.996 −60.764 1.00 43.55 O ATOM 7120 NE2 GLN A 993 −13.393 47.990 −61.948 1.00 43.48 N ATOM 7121 C GLN A 993 −13.992 44.520 −58.587 1.00 29.34 C ATOM 7122 O GLN A 993 −14.024 44.093 −57.428 1.00 30.11 O ATOM 7123 N GLU A 994 −13.527 43.812 −59.605 1.00 26.76 N ATOM 7124 CA GLU A 994 −13.116 42.429 −59.457 1.00 25.56 C ATOM 7125 CB GLU A 994 −13.357 41.681 −60.774 1.00 27.70 C ATOM 7126 CG GLU A 994 −13.478 40.174 −60.626 1.00 30.10 C ATOM 7127 CD GLU A 994 −14.043 39.492 −61.865 1.00 31.75 C ATOM 7128 OE1 GLU A 994 −13.563 39.788 −62.987 1.00 33.36 O ATOM 7129 OE2 GLU A 994 −14.950 38.636 −61.710 1.00 31.93 O ATOM 7130 C GLU A 994 −11.643 42.357 −59.048 1.00 23.21 C ATOM 7131 O GLU A 994 −10.764 42.386 −59.898 1.00 22.85 O ATOM 7132 N VAL A 995 −11.386 42.250 −57.745 1.00 20.91 N ATOM 7133 CA VAL A 995 −10.026 42.363 −57.210 1.00 18.71 C ATOM 7134 CB VAL A 995 −9.976 43.206 −55.930 1.00 17.73 C ATOM 7135 CG1 VAL A 995 −10.435 44.616 −56.224 1.00 17.40 C ATOM 7136 CG2 VAL A 995 −10.807 42.575 −54.834 1.00 17.53 C ATOM 7137 C VAL A 995 −9.294 41.056 −56.948 1.00 18.14 C ATOM 7138 O VAL A 995 −8.125 41.077 −56.568 1.00 18.46 O ATOM 7139 N GLY A 996 −9.963 39.923 −57.140 1.00 17.33 N ATOM 7140 CA GLY A 996 −9.320 38.631 −56.912 1.00 16.20 C ATOM 7141 C GLY A 996 −9.964 37.502 −57.674 1.00 15.74 C ATOM 7142 O GLY A 996 −11.177 37.354 −57.645 1.00 16.19 O ATOM 7143 N LEU A 997 −9.152 36.720 −58.378 1.00 15.36 N ATOM 7144 CA LEU A 997 −9.608 35.479 −59.016 1.00 15.14 C ATOM 7145 CB LEU A 997 −9.653 35.626 −60.544 1.00 15.66 C ATOM 7146 CG LEU A 997 −10.241 36.882 −61.213 1.00 16.14 C ATOM 7147 CD1 LEU A 997 −10.220 36.745 −62.730 1.00 16.33 C ATOM 7148 CD2 LEU A 997 −11.661 37.184 −60.747 1.00 16.52 C ATOM 7149 C LEU A 997 −8.660 34.337 −58.637 1.00 14.69 C ATOM 7150 O LEU A 997 −7.465 34.575 −58.414 1.00 14.95 O ATOM 7151 N PHE A 998 −9.180 33.108 −58.582 1.00 13.81 N ATOM 7152 CA PHE A 998 −8.385 31.928 −58.227 1.00 13.32 C ATOM 7153 CB PHE A 998 −8.227 31.872 −56.717 1.00 13.40 C ATOM 7154 CG PHE A 998 −7.219 30.867 −56.230 1.00 13.51 C ATOM 7155 CD1 PHE A 998 −5.865 30.999 −56.546 1.00 13.31 C ATOM 7156 CE1 PHE A 998 −4.936 30.091 −56.077 1.00 13.10 C ATOM 7157 CZ PHE A 998 −5.342 29.050 −55.261 1.00 13.32 C ATOM 7158 CE2 PHE A 998 −6.683 28.906 −54.927 1.00 16.45 C ATOM 7159 CD2 PHE A 998 −7.615 29.815 −55.406 1.00 13.45 C ATOM 7160 C PHE A 998 −9.106 30.682 −58.671 1.00 13.25 C ATOM 7161 O PHE A 998 −10.275 30.515 −58.358 1.00 13.56 O ATOM 7162 N HIS A 999 −8.433 29.798 −59.400 1.00 13.21 N ATOM 7163 CA HIS A 999 −9.045 28.507 −59.733 1.00 12.90 C ATOM 7164 CB HIS A 999 −8.454 27.923 −61.001 1.00 13.24 C ATOM 7165 CG HIS A 999 −9.203 26.717 −61.500 1.00 13.99 C ATOM 7166 ND1 HIS A 999 −8.762 25.449 −61.310 1.00 14.10 N ATOM 7167 CE1 HIS A 999 −9.648 24.580 −61.858 1.00 14.00 C ATOM 7168 NE2 HIS A 999 −10.673 25.297 −62.378 1.00 14.00 N ATOM 7169 CD2 HIS A 999 −10.434 26.611 −62.176 1.00 14.01 C ATOM 7170 C HIS A 999 −8.831 27.554 −58.612 1.00 12.62 C ATOM 7171 O HIS A 999 −7.721 27.057 −58.443 1.00 12.81 O ATOM 7172 N LEU A 1000 −9.879 27.277 −57.834 1.00 12.17 N ATOM 7173 CA LEU A 1000 −9.750 26.430 −56.629 1.00 11.82 C ATOM 7174 CB LEU A 1000 −10.908 26.668 −55.657 1.00 11.69 C ATOM 7175 CG LEU A 1000 −10.911 25.912 −54.320 1.00 11.54 C ATOM 7176 CD1 LEU A 1000 −9.652 26.169 −53.523 1.00 11.61 C ATOM 7177 CD2 LEU A 1000 −12.108 26.307 −53.490 1.00 11.48 C ATOM 7178 C LEU A 1000 −9.611 24.935 −56.914 1.00 11.63 C ATOM 7179 O LEU A 1000 −8.790 24.279 −56.317 1.00 11.37 O ATOM 7180 N GLY A 1001 −10.415 24.399 −57.822 1.00 11.74 N ATOM 7181 CA GLY A 1001 −10.391 22.955 −58.105 1.00 11.73 C ATOM 7182 C GLY A 1001 −11.505 22.198 −57.396 1.00 11.74 C ATOM 7183 O GLY A 1001 −11.635 20.980 −57.551 1.00 11.56 O ATOM 7184 N GLU A 1002 −12.300 22.935 −56.617 1.00 11.67 N ATOM 7185 CA GLU A 1002 −13.474 22.409 −55.934 1.00 11.64 C ATOM 7186 CB GLU A 1002 −13.256 22.446 −54.418 1.00 11.84 C ATOM 7187 CG GLU A 1002 −12.072 21.630 −53.916 1.00 12.27 C ATOM 7188 CD GLU A 1002 −12.255 20.130 −54.122 1.00 12.96 C ATOM 7189 OE1 GLU A 1002 −13.422 19.669 −54.304 1.00 13.31 O ATOM 7190 OE2 GLU A 1002 −11.231 19.403 −54.098 1.00 12.87 O ATOM 7191 C GLU A 1002 −14.755 23.190 −56.306 1.00 11.54 C ATOM 7192 O GLU A 1002 −14.687 24.302 −56.832 1.00 11.57 O ATOM 7193 N PHE A 1003 −15.918 22.592 −56.041 1.00 11.14 N ATOM 7194 CA PHE A 1003 −17.198 23.272 −56.180 1.00 10.64 C ATOM 7195 CB PHE A 1003 −18.207 22.351 −56.869 1.00 10.51 C ATOM 7196 CG PHE A 1003 −19.549 22.994 −57.170 1.00 10.36 C ATOM 7197 CD1 PHE A 1003 −20.521 23.133 −56.180 1.00 10.21 C ATOM 7198 CE1 PHE A 1003 −21.758 23.691 −56.462 1.00 9.97 C ATOM 7199 CZ PHE A 1003 −22.050 24.106 −57.741 1.00 9.98 C ATOM 7200 CE2 PHE A 1003 −21.105 23.958 −58.744 1.00 10.11 C ATOM 7201 CD2 PHE A 1003 −19.863 23.405 −58.460 1.00 10.25 C ATOM 7202 C PHE A 1003 −17.643 23.576 −54.773 1.00 10.51 C ATOM 7203 O PHE A 1003 −17.958 22.669 −54.010 1.00 10.77 O ATOM 7204 N VAL A 1004 −17.632 24.849 −54.412 1.00 10.44 N ATOM 7205 CA VAL A 1004 −17.988 25.272 −53.055 1.00 10.48 C ATOM 7206 CB VAL A 1004 −17.333 26.639 −52.678 1.00 10.22 C ATOM 7207 CG1 VAL A 1004 −17.918 27.206 −51.392 1.00 10.13 C ATOM 7208 CG2 VAL A 1004 −15.830 26.492 −52.548 1.00 10.09 C ATOM 7209 C VAL A 1004 −19.509 25.359 −52.923 1.00 10.60 C ATOM 7210 O VAL A 1004 −20.155 26.046 −53.716 1.00 10.80 O ATOM 7211 N ASN A 1005 −20.069 24.676 −51.924 1.00 10.41 N ATOM 7212 CA ASN A 1005 −21.487 24.798 −51.630 1.00 10.52 C ATOM 7213 CB ASN A 1005 −22.092 23.442 −51.250 1.00 10.59 C ATOM 7214 CG ASN A 1005 −22.273 22.533 −52.443 1.00 10.68 C ATOM 7215 OD1 ASN A 1005 −22.656 22.988 −53.514 1.00 11.13 O ATOM 7216 ND2 ASN A 1005 −22.008 21.244 −52.268 1.00 10.46 N ATOM 7217 C ASN A 1005 −21.781 25.821 −50.542 1.00 10.60 C ATOM 7218 O ASN A 1005 −22.826 26.476 −50.568 1.00 10.47 O ATOM 7219 N VAL A 1006 −20.863 25.964 −49.593 1.00 10.80 N ATOM 7220 CA VAL A 1006 −21.164 26.696 −48.354 1.00 11.27 C ATOM 7221 CB VAL A 1006 −21.793 25.772 −47.280 1.00 10.96 C ATOM 7222 CG1 VAL A 1006 −21.024 24.462 −47.170 1.00 11.00 C ATOM 7223 CG2 VAL A 1006 −21.855 26.458 −45.933 1.00 10.77 C ATOM 7224 C VAL A 1006 −19.946 27.413 −47.781 1.00 11.78 C ATOM 7225 O VAL A 1006 −18.866 26.843 −47.679 1.00 11.76 O ATOM 7226 N PHE A 1007 −20.143 28.681 −47.449 1.00 12.58 N ATOM 7227 CA PHE A 1007 −19.152 29.494 −46.773 1.00 13.45 C ATOM 7228 CB PHE A 1007 −19.001 30.855 −47.472 1.00 12.55 C ATOM 7229 CG PHE A 1007 −18.266 30.809 −48.784 1.00 11.95 C ATOM 7230 CD1 PHE A 1007 −16.919 30.421 −48.844 1.00 11.87 C ATOM 7231 CE1 PHE A 1007 −16.237 30.390 −50.054 1.00 11.49 C ATOM 7232 CZ PHE A 1007 −16.887 30.779 −51.216 1.00 11.37 C ATOM 7233 CE2 PHE A 1007 −18.217 31.183 −51.169 1.00 11.43 C ATOM 7234 CD2 PHE A 1007 −18.897 31.202 −49.958 1.00 11.57 C ATOM 7235 C PHE A 1007 −19.701 29.747 −45.381 1.00 14.86 C ATOM 7236 O PHE A 1007 −20.901 29.991 −45.218 1.00 14.93 O ATOM 7237 N CYS A 1008 −18.839 29.717 −44.377 1.00 16.84 N ATOM 7238 CA CYS A 1008 −19.220 30.269 −43.091 1.00 18.70 C ATOM 7239 CB CYS A 1008 −20.041 29.272 −42.289 1.00 19.72 C ATOM 7240 SG CYS A 1008 −19.068 27.939 −41.585 1.00 22.87 S ATOM 7241 C CYS A 1008 −18.048 30.782 −42.281 1.00 19.58 C ATOM 7242 O CYS A 1008 −16.959 30.235 −42.321 1.00 18.72 O ATOM 7243 N HIS A 1009 −18.305 31.864 −41.561 1.00 22.07 N ATOM 7244 CA HIS A 1009 −17.361 32.456 −40.639 1.00 24.60 C ATOM 7245 CB HIS A 1009 −17.924 33.774 −40.146 1.00 24.69 C ATOM 7246 CG HIS A 1009 −18.026 34.819 −41.235 1.00 25.38 C ATOM 7247 ND1 HIS A 1009 −17.049 35.722 −41.470 1.00 26.09 N ATOM 7248 CE1 HIS A 1009 −17.389 36.487 −42.518 1.00 25.87 C ATOM 7249 NE2 HIS A 1009 −18.579 36.064 −42.971 1.00 25.80 N ATOM 7250 CD2 HIS A 1009 −18.996 35.033 −42.205 1.00 25.50 C ATOM 7251 C HIS A 1009 −17.121 31.506 −39.520 1.00 27.52 C ATOM 7252 O HIS A 1009 −18.061 30.888 −39.029 1.00 28.52 O ATOM 7253 N GLY A 1010 −15.861 31.330 −39.130 1.00 32.03 N ATOM 7254 CA GLY A 1010 −15.520 30.289 −38.155 1.00 37.59 C ATOM 7255 C GLY A 1010 −14.139 30.372 −37.530 1.00 43.77 C ATOM 7256 O GLY A 1010 −13.410 31.345 −37.735 1.00 45.27 O ATOM 7257 N SER A 1011 −13.792 29.345 −36.747 1.00 47.42 N ATOM 7258 CA SER A 1011 −12.465 29.235 −36.134 1.00 48.77 C ATOM 7259 CB SER A 1011 −12.392 30.061 −34.839 1.00 49.73 C ATOM 7260 OG SER A 1011 −11.207 29.774 −34.110 1.00 50.58 O ATOM 7261 C SER A 1011 −12.033 27.770 −35.901 1.00 50.52 C ATOM 7262 O SER A 1011 −12.531 27.089 −34.987 1.00 50.03 O ATOM 7263 N LEU A 1012 −11.107 27.305 −36.750 1.00 50.32 N ATOM 7264 CA LEU A 1012 −10.468 25.981 −36.617 1.00 47.73 C ATOM 7265 CB LEU A 1012 −9.709 25.593 −37.911 1.00 42.40 C ATOM 7266 CG LEU A 1012 −10.390 25.477 −39.287 1.00 37.21 C ATOM 7267 CD1 LEU A 1012 −9.428 24.943 −40.320 1.00 32.24 C ATOM 7268 CD2 LEU A 1012 −11.636 24.609 −39.251 1.00 35.27 C ATOM 7269 C LEU A 1012 −9.464 25.985 −35.477 1.00 48.84 C ATOM 7270 O LEU A 1012 −9.409 25.039 −34.687 1.00 49.57 O ATOM 7271 N VAL A 1013 −8.735 27.103 −35.379 1.00 50.31 N ATOM 7272 CA VAL A 1013 −7.367 27.200 −34.826 1.00 49.45 C ATOM 7273 CB VAL A 1013 −7.283 27.168 −33.278 1.00 50.72 C ATOM 7274 CG1 VAL A 1013 −5.962 27.791 −32.829 1.00 52.64 C ATOM 7275 CG2 VAL A 1013 −8.454 27.911 −32.642 1.00 51.09 C ATOM 7276 C VAL A 1013 −6.412 26.177 −35.456 1.00 49.86 C ATOM 7277 O VAL A 1013 −6.564 24.964 −35.277 1.00 49.98 O ATOM 7278 N THR A 1024 −2.434 37.070 −40.728 1.00 37.70 N ATOM 7279 CA THR A 1024 −3.728 36.698 −41.328 1.00 37.51 C ATOM 7280 CB THR A 1024 −3.850 35.169 −41.546 1.00 35.58 C ATOM 7281 OG1 THR A 1024 −4.004 34.511 −40.287 1.00 35.93 O ATOM 7282 CG2 THR A 1024 −2.626 34.616 −42.247 1.00 33.94 C ATOM 7283 C THR A 1024 −4.931 37.198 −40.503 1.00 37.68 C ATOM 7284 O THR A 1024 −4.955 37.057 −39.285 1.00 38.63 O ATOM 7285 N GLN A 1025 −5.930 37.764 −41.175 1.00 38.15 N ATOM 7286 CA GLN A 1025 −7.051 38.423 −40.492 1.00 39.94 C ATOM 7287 CB GLN A 1025 −6.994 39.934 −40.745 1.00 41.20 C ATOM 7288 CG GLN A 1025 −5.702 40.587 −40.266 1.00 43.85 C ATOM 7289 CD GLN A 1025 −4.947 41.318 −41.368 1.00 44.62 C ATOM 7290 OE1 GLN A 1025 −5.536 41.774 −42.352 1.00 45.82 O ATOM 7291 NE2 GLN A 1025 −3.633 41.430 −41.206 1.00 43.50 N ATOM 7292 C GLN A 1025 −8.442 37.858 −40.876 1.00 40.58 C ATOM 7293 O GLN A 1025 −8.776 37.729 −42.075 1.00 40.34 O ATOM 7294 N GLY A 1026 −9.244 37.531 −39.855 1.00 37.54 N ATOM 7295 CA GLY A 1026 −10.586 36.978 −40.065 1.00 34.95 C ATOM 7296 C GLY A 1026 −10.501 35.512 −40.428 1.00 33.44 C ATOM 7297 O GLY A 1026 −9.429 34.919 −40.333 1.00 36.78 O ATOM 7298 N SER A 1027 −11.617 34.913 −40.840 1.00 29.21 N ATOM 7299 CA SER A 1027 −11.621 33.491 −41.172 1.00 26.30 C ATOM 7300 CB SER A 1027 −11.234 32.658 −39.942 1.00 26.03 C ATOM 7301 OG SER A 1027 −11.586 31.299 −40.117 1.00 26.59 O ATOM 7302 C SER A 1027 −12.952 33.008 −41.752 1.00 24.66 C ATOM 7303 O SER A 1027 −13.970 32.957 −41.059 1.00 25.58 O ATOM 7304 N VAL A 1028 −12.933 32.649 −43.028 1.00 22.39 N ATOM 7305 CA VAL A 1028 −14.085 32.040 −43.672 1.00 20.83 C ATOM 7306 CB VAL A 1028 −14.479 32.789 −44.950 1.00 20.47 C ATOM 7307 CG1 VAL A 1028 −15.621 32.070 −45.645 1.00 20.07 C ATOM 7308 CG2 VAL A 1028 −14.854 34.225 −44.629 1.00 20.67 C ATOM 7309 C VAL A 1028 −13.740 30.613 −44.056 1.00 20.06 C ATOM 7310 O VAL A 1028 −12.726 30.370 −44.716 1.00 20.31 O ATOM 7311 N LEU A 1029 −14.579 29.671 −43.637 1.00 18.57 N ATOM 7312 CA LEU A 1029 −14.413 28.271 −44.006 1.00 16.82 C ATOM 7313 CB LEU A 1029 −14.729 27.362 −42.827 1.00 16.77 C ATOM 7314 CG LEU A 1029 −14.146 27.721 −41.471 1.00 16.92 C ATOM 7315 CD1 LEU A 1029 −14.977 27.130 −40.347 1.00 16.97 C ATOM 7316 CD2 LEU A 1029 −12.714 27.251 −41.390 1.00 17.64 C ATOM 7317 C LEU A 1029 −15.361 27.952 −45.138 1.00 15.79 C ATOM 7318 O LEU A 1029 −16.423 28.567 −45.256 1.00 15.52 O ATOM 7319 N PHE A 1030 −14.970 27.001 −45.981 1.00 14.78 N ATOM 7320 CA PHE A 1030 −15.858 26.516 −47.027 1.00 13.92 C ATOM 7321 CB PHE A 1030 −15.558 27.146 −48.397 1.00 13.46 C ATOM 7322 CG PHE A 1030 −14.166 26.881 −48.919 1.00 13.51 C ATOM 7323 CD1 PHE A 1030 −13.874 25.707 −49.620 1.00 13.29 C ATOM 7324 CE1 PHE A 1030 −12.605 25.482 −50.116 1.00 13.18 C ATOM 7325 CZ PHE A 1030 −11.616 26.437 −49.943 1.00 13.16 C ATOM 7326 CE2 PHE A 1030 −11.893 27.617 −49.275 1.00 13.10 C ATOM 7327 CD2 PHE A 1030 −13.160 27.841 −48.776 1.00 13.31 C ATOM 7328 C PHE A 1030 −15.922 25.005 −47.101 1.00 13.46 C ATOM 7329 O PHE A 1030 −14.934 24.320 −46.856 1.00 13.53 O ATOM 7330 N GLY A 1031 −17.114 24.503 −47.393 1.00 13.09 N ATOM 7331 CA GLY A 1031 −17.323 23.090 −47.650 1.00 12.94 C ATOM 7332 C GLY A 1031 −17.711 22.847 −49.097 1.00 12.84 C ATOM 7333 O GLY A 1031 −18.229 23.727 −49.789 1.00 12.90 O ATOM 7334 N THR A 1032 −17.526 21.618 −49.536 1.00 12.78 N ATOM 7335 CA THR A 1032 −17.328 21.362 −50.933 1.00 12.29 C ATOM 7336 CB THR A 1032 −15.836 21.403 −51.162 1.00 12.33 C ATOM 7337 OG1 THR A 1032 −15.571 22.321 −52.202 1.00 13.25 O ATOM 7338 CG2 THR A 1032 −15.272 20.059 −51.462 1.00 12.33 C ATOM 7339 C THR A 1032 −17.945 20.036 −51.394 1.00 12.18 C ATOM 7340 O THR A 1032 −18.226 19.154 −50.583 1.00 12.06 O ATOM 7341 N VAL A 1033 −18.178 19.915 −52.694 1.00 12.17 N ATOM 7342 CA VAL A 1033 −18.793 18.716 −53.272 1.00 12.34 C ATOM 7343 CB VAL A 1033 −19.080 18.909 −54.779 1.00 12.00 C ATOM 7344 CG1 VAL A 1033 −19.368 17.589 −55.455 1.00 11.90 C ATOM 7345 CG2 VAL A 1033 −20.236 19.862 −54.984 1.00 11.82 C ATOM 7346 C VAL A 1033 −17.943 17.456 −53.049 1.00 12.85 C ATOM 7347 O VAL A 1033 −18.470 16.404 −52.691 1.00 13.39 O ATOM 7348 N ASN A 1034 −16.634 17.563 −53.272 1.00 13.29 N ATOM 7349 CA ASN A 1034 −15.714 16.443 −53.094 1.00 13.53 C ATOM 7350 CB ASN A 1034 −14.409 16.717 −53.832 1.00 14.09 C ATOM 7351 CG ASN A 1034 −14.580 16.698 −55.330 1.00 14.92 C ATOM 7352 OD1 ASN A 1034 −14.093 17.574 −56.038 1.00 15.77 O ATOM 7353 ND2 ASN A 1034 −15.281 15.703 −55.823 1.00 15.14 N ATOM 7354 C ASN A 1034 −15.415 16.155 −51.636 1.00 13.65 C ATOM 7355 O ASN A 1034 −14.677 15.229 −51.321 1.00 13.70 O ATOM 7356 N GLY A 1035 −15.968 16.966 −50.745 1.00 14.03 N ATOM 7357 CA GLY A 1035 −15.749 16.785 −49.313 1.00 14.79 C ATOM 7358 C GLY A 1035 −14.474 17.405 −48.763 1.00 15.43 C ATOM 7359 O GLY A 1035 −13.975 16.986 −47.708 1.00 15.90 O ATOM 7360 N MET A 1036 −13.957 18.415 −49.458 1.00 15.28 N ATOM 7361 CA MET A 1036 −12.799 19.158 −48.995 1.00 15.06 C ATOM 7362 CB MET A 1036 −12.005 19.642 −50.206 1.00 15.97 C ATOM 7363 CG MET A 1036 −10.759 20.461 −49.921 1.00 16.53 C ATOM 7364 SD MET A 1036 −11.088 22.231 −49.952 1.00 17.60 S ATOM 7365 CE MET A 1036 −9.452 22.855 −50.322 1.00 16.67 C ATOM 7366 C MET A 1036 −13.290 20.325 −48.162 1.00 14.83 C ATOM 7367 O MET A 1036 −14.312 20.930 −48.474 1.00 15.15 O ATOM 7368 N ILE A 1037 −12.590 20.609 −47.072 1.00 14.46 N ATOM 7369 CA ILE A 1037 −12.873 21.791 −46.258 1.00 14.00 C ATOM 7370 CB ILE A 1037 −13.110 21.471 −44.768 1.00 13.38 C ATOM 7371 CG1 ILE A 1037 −14.227 20.458 −44.625 1.00 13.06 C ATOM 7372 CD1 ILE A 1037 −14.350 19.892 −43.236 1.00 13.12 C ATOM 7373 CG2 ILE A 1037 −13.480 22.733 −44.001 1.00 13.26 C ATOM 7374 C ILE A 1037 −11.690 22.725 −46.394 1.00 14.31 C ATOM 7375 O ILE A 1037 −10.521 22.298 −46.303 1.00 13.93 O ATOM 7376 N GLY A 1038 −12.002 23.999 −46.628 1.00 14.48 N ATOM 7377 CA GLY A 1038 −10.983 24.997 −46.870 1.00 14.69 C ATOM 7378 C GLY A 1038 −11.093 26.171 −45.940 1.00 14.98 C ATOM 7379 O GLY A 1038 −12.063 26.307 −45.193 1.00 15.00 O ATOM 7380 N LEU A 1039 −10.086 27.028 −45.995 1.00 15.27 N ATOM 7381 CA LEU A 1039 −10.071 28.228 −45.206 1.00 15.70 C ATOM 7382 CB LEU A 1039 −9.165 28.025 −44.017 1.00 16.05 C ATOM 7383 CG LEU A 1039 −9.277 29.035 −42.900 1.00 16.50 C ATOM 7384 CD1 LEU A 1039 −9.068 28.302 −41.589 1.00 17.12 C ATOM 7385 CD2 LEU A 1039 −8.238 30.134 −43.097 1.00 16.80 C ATOM 7386 C LEU A 1039 −9.598 29.399 −46.049 1.00 15.83 C ATOM 7387 O LEU A 1039 −8.668 29.273 −46.845 1.00 16.01 O ATOM 7388 N VAL A 1040 −10.264 30.532 −45.885 1.00 15.95 N ATOM 7389 CA VAL A 1040 −9.884 31.757 −46.573 1.00 16.10 C ATOM 7390 CB VAL A 1040 −10.957 32.215 −47.591 1.00 15.48 C ATOM 7391 CG1 VAL A 1040 −10.583 33.548 −48.197 1.00 15.28 C ATOM 7392 CG2 VAL A 1040 −11.121 31.191 −48.697 1.00 15.36 C ATOM 7393 C VAL A 1040 −9.677 32.830 −45.520 1.00 16.79 C ATOM 7394 O VAL A 1040 −10.490 32.987 −44.608 1.00 16.96 O ATOM 7395 N THR A 1041 −8.575 33.553 −45.629 1.00 17.75 N ATOM 7396 CA THR A 1041 −8.330 34.653 −44.721 1.00 19.00 C ATOM 7397 CB THR A 1041 −7.616 34.203 −43.438 1.00 19.37 C ATOM 7398 OG1 THR A 1041 −7.448 35.337 −42.584 1.00 19.82 O ATOM 7399 CG2 THR A 1041 −6.243 33.587 −43.755 1.00 19.71 C ATOM 7400 C THR A 1041 −7.583 35.809 −45.371 1.00 19.73 C ATOM 7401 O THR A 1041 −6.896 35.647 −46.378 1.00 19.63 O ATOM 7402 N SER A 1042 −7.731 36.980 −44.775 1.00 20.63 N ATOM 7403 CA SER A 1042 −7.195 38.179 −45.349 1.00 21.56 C ATOM 7404 CB SER A 1042 −8.034 39.380 −44.930 1.00 23.04 C ATOM 7405 OG SER A 1042 −9.186 39.492 −45.758 1.00 25.52 O ATOM 7406 C SER A 1042 −5.740 38.375 −44.970 1.00 21.98 C ATOM 7407 O SER A 1042 −5.305 37.997 −43.874 1.00 22.57 O ATOM 7408 N LEU A 1043 −4.992 38.971 −45.896 1.00 21.35 N ATOM 7409 CA LEU A 1043 −3.600 39.309 −45.683 1.00 20.71 C ATOM 7410 CB LEU A 1043 −2.718 38.542 −46.661 1.00 20.24 C ATOM 7411 CG LEU A 1043 −2.503 37.078 −46.342 1.00 19.60 C ATOM 7412 CD1 LEU A 1043 −1.702 36.423 −47.444 1.00 19.02 C ATOM 7413 CD2 LEU A 1043 −1.781 36.988 −45.015 1.00 20.28 C ATOM 7414 C LEU A 1043 −3.405 40.773 −45.921 1.00 20.46 C ATOM 7415 O LEU A 1043 −4.033 41.341 −46.813 1.00 19.78 O ATOM 7416 N SER A 1044 −2.518 41.380 −45.142 1.00 21.18 N ATOM 7417 CA SER A 1044 −2.103 42.749 −45.418 1.00 22.26 C ATOM 7418 CB SER A 1044 −1.366 43.377 −44.218 1.00 22.31 C ATOM 7419 OG SER A 1044 −0.062 42.847 −44.051 1.00 23.08 O ATOM 7420 C SER A 1044 −1.256 42.784 −46.696 1.00 22.71 C ATOM 7421 O SER A 1044 −0.546 41.817 −47.014 1.00 23.63 O ATOM 7422 N GLU A 1045 −1.368 43.887 −47.430 1.00 22.78 N ATOM 7423 CA GLU A 1045 −0.648 44.115 −48.688 1.00 23.19 C ATOM 7424 CB GLU A 1045 −0.802 45.582 −49.075 1.00 25.08 C ATOM 7425 CG GLU A 1045 −0.262 45.977 −50.435 1.00 26.53 C ATOM 7426 CD GLU A 1045 −0.539 47.439 −50.759 1.00 28.39 C ATOM 7427 OE1 GLU A 1045 −1.064 48.175 −49.878 1.00 28.76 O ATOM 7428 OE2 GLU A 1045 −0.237 47.850 −51.905 1.00 29.16 O ATOM 7429 C GLU A 1045 0.837 43.743 −48.630 1.00 22.69 C ATOM 7430 O GLU A 1045 1.407 43.275 −49.621 1.00 22.42 O ATOM 7431 N SER A 1046 1.457 43.966 −47.473 1.00 22.05 N ATOM 7432 CA SER A 1046 2.858 43.605 −47.255 1.00 21.30 C ATOM 7433 CB SER A 1046 3.327 44.070 −45.867 1.00 21.15 C ATOM 7434 OG SER A 1046 4.709 43.807 −45.658 1.00 20.79 O ATOM 7435 C SER A 1046 3.061 42.099 −47.413 1.00 20.95 C ATOM 7436 O SER A 1046 3.939 41.655 −48.163 1.00 20.73 O ATOM 7437 N TRP A 1047 2.236 41.320 −46.715 1.00 20.48 N ATOM 7438 CA TRP A 1047 2.322 39.861 −46.770 1.00 20.22 C ATOM 7439 CB TRP A 1047 1.490 39.251 −45.666 1.00 21.44 C ATOM 7440 CG TRP A 1047 2.135 39.411 −44.325 1.00 22.63 C ATOM 7441 CD1 TRP A 1047 1.859 40.371 −43.361 1.00 23.04 C ATOM 7442 NE1 TRP A 1047 2.650 40.191 −42.256 1.00 22.87 N ATOM 7443 CE2 TRP A 1047 3.474 39.146 −42.429 1.00 23.10 C ATOM 7444 CD2 TRP A 1047 3.194 38.591 −43.753 1.00 23.24 C ATOM 7445 CE3 TRP A 1047 3.915 37.492 −44.188 1.00 24.16 C ATOM 7446 CZ3 TRP A 1047 4.896 36.958 −43.336 1.00 24.22 C ATOM 7447 CH2 TRP A 1047 5.149 37.508 −42.071 1.00 24.12 C ATOM 7448 CZ2 TRP A 1047 4.443 38.613 −41.597 1.00 23.81 C ATOM 7449 C TRP A 1047 1.946 39.265 −48.109 1.00 18.75 C ATOM 7450 O TRP A 1047 2.561 38.293 −45.572 1.00 17.70 O ATOM 7451 N TYR A 1048 0.936 39.834 −48.749 1.00 17.41 N ATOM 7452 CA TYR A 1048 0.581 39.371 −50.074 1.00 16.70 C ATOM 7453 CB TYR A 1048 −0.681 40.057 −50.583 1.00 15.37 C ATOM 7454 CG TYR A 1048 −1.003 39.697 −51.998 1.00 14.74 C ATOM 7455 CD1 TYR A 1048 −1.614 38.485 −52.305 1.00 14.50 C ATOM 7456 CE1 TYR A 1048 −1.917 38.140 −53.616 1.00 14.15 C ATOM 7457 CZ TYR A 1048 −1.594 39.010 −54.637 1.00 14.05 C ATOM 7458 OH TYR A 1048 −1.883 38.674 −55.939 1.00 13.68 O ATOM 7459 CE2 TYR A 1048 −0.981 40.222 −54.354 1.00 14.29 C ATOM 7460 CD2 TYR A 1048 −0.684 40.555 −53.042 1.00 14.46 C ATOM 7461 C TYR A 1048 1.763 39.520 −51.059 1.00 16.86 C ATOM 7462 O TYR A 1048 2.093 38.578 −51.791 1.00 16.84 O ATOM 7463 N ASN A 1049 2.407 40.688 −51.063 1.00 16.82 N ATOM 7464 CA ASN A 1049 3.565 40.888 −51.923 1.00 16.88 C ATOM 7465 CB ASN A 1049 4.060 42.330 −51.866 1.00 17.43 C ATOM 7466 CG ASN A 1049 3.096 43.314 −52.527 1.00 18.23 C ATOM 7467 OD1 ASN A 1049 2.470 43.018 −53.550 1.00 18.17 O ATOM 7468 ND2 ASN A 1049 2.993 44.510 −51.949 1.00 18.78 N ATOM 7469 C ASN A 1049 4.688 39.889 −51.612 1.00 16.62 C ATOM 7470 O ASN A 1049 5.228 39.252 −52.526 1.00 16.61 O ATOM 7471 N LEU A 1050 5.001 39.718 −50.326 1.00 16.13 N ATOM 7472 CA LEU A 1050 6.021 38.746 −49.910 1.00 15.60 C ATOM 7473 CB LEU A 1050 6.216 38.729 −48.388 1.00 15.22 C ATOM 7474 CG LEU A 1050 7.148 37.641 −47.827 1.00 14.82 C ATOM 7475 CD1 LEU A 1050 8.605 37.858 −48.222 1.00 14.42 C ATOM 7476 CD2 LEU A 1050 7.019 37.596 −46.316 1.00 14.94 C ATOM 7477 C LEU A 1050 5.695 37.345 −50.385 1.00 15.45 C ATOM 7478 O LEU A 1050 6.548 36.672 −50.956 1.00 15.35 O ATOM 7479 N LEU A 1051 4.460 36.909 −50.142 1.00 15.42 N ATOM 7480 CA LEU A 1051 4.075 35.539 −50.449 1.00 15.24 C ATOM 7481 CB LEU A 1051 2.834 35.103 −49.658 1.00 14.68 C ATOM 7482 CG LEU A 1051 3.031 34.927 −48.137 1.00 14.22 C ATOM 7483 CD1 LEU A 1051 1.712 34.839 −47.393 1.00 14.01 C ATOM 7484 CD2 LEU A 1051 3.893 33.729 −47.801 1.00 13.79 C ATOM 7485 C LEU A 1051 3.929 35.312 −51.946 1.00 15.68 C ATOM 7486 O LEU A 1051 4.203 34.216 −52.430 1.00 15.93 O ATOM 7487 N LEU A 1052 3.560 36.358 −52.686 1.00 16.42 N ATOM 7488 CA LEU A 1052 3.513 36.271 −54.150 1.00 17.17 C ATOM 7489 CB LEU A 1052 2.877 37.527 −54.769 1.00 16.72 C ATOM 7490 CG LEU A 1052 1.900 37.349 −55.953 1.00 16.37 C ATOM 7491 CD1 LEU A 1052 1.320 38.694 −56.332 1.00 16.35 C ATOM 7492 CD2 LEU A 1052 2.520 36.705 −57.186 1.00 16.47 C ATOM 7493 C LEU A 1052 4.908 35.992 −54.756 1.00 18.11 C ATOM 7494 O LEU A 1052 5.049 35.129 −55.631 1.00 17.33 O ATOM 7495 N ASP A 1053 5.923 36.725 −54.288 1.00 19.86 N ATOM 7496 CA ASP A 1053 7.311 36.444 −54.656 1.00 21.89 C ATOM 7497 CB ASP A 1053 8.266 37.254 −53.792 1.00 24.04 C ATOM 7498 CG ASP A 1053 8.560 38.627 −54.358 1.00 26.14 C ATOM 7499 OD1 ASP A 1053 7.598 39.317 −54.780 1.00 26.90 O ATOM 7500 OD2 ASP A 1053 9.758 39.023 −54.348 1.00 26.86 O ATOM 7501 C ASP A 1053 7.607 34.979 −54.411 1.00 22.42 C ATOM 7502 O ASP A 1053 8.084 34.257 −55.292 1.00 22.95 O ATOM 7503 N MET A 1054 7.294 34.547 −53.198 1.00 22.76 N ATOM 7504 CA MET A 1054 7.636 33.232 −52.734 1.00 22.58 C ATOM 7505 CB MET A 1054 7.198 33.080 −51.307 1.00 23.58 C ATOM 7506 CG MET A 1054 8.057 32.105 −50.557 1.00 25.65 C ATOM 7507 SD MET A 1054 7.670 32.223 −48.813 1.00 28.01 S ATOM 7508 CE MET A 1054 7.950 30.511 −48.333 1.00 26.01 C ATOM 7509 C MET A 1054 7.028 32.137 −53.585 1.00 22.18 C ATOM 7510 O MET A 1054 7.731 31.206 −53.977 1.00 22.45 O ATOM 7511 N GLN A 1055 5.734 32.250 −53.881 1.00 21.35 N ATOM 7512 CA GLN A 1055 5.074 31.303 −54.783 1.00 21.28 C ATOM 7513 CB GLN A 1055 3.646 31.737 −55.099 1.00 20.49 C ATOM 7514 CG GLN A 1055 2.651 31.348 −54.020 1.00 19.91 C ATOM 7515 CD GLN A 1055 1.217 31.686 −54.377 1.00 20.07 C ATOM 7516 OE1 GLN A 1055 0.944 32.426 −55.324 1.00 20.18 O ATOM 7517 NE2 GLN A 1055 0.293 31.159 −53.605 1.00 19.48 N ATOM 7518 C GLN A 1055 5.859 31.101 −56.074 1.00 21.67 C ATOM 7519 O GLN A 1055 6.111 29.969 −56.491 1.00 21.44 O ATOM 7520 N ASN A 1056 6.275 32.207 −56.676 1.00 22.47 N ATOM 7521 CA ASN A 1056 6.963 32.173 −57.952 1.00 23.29 C ATOM 7522 CB ASN A 1056 7.133 33.579 −58.505 1.00 24.08 C ATOM 7523 CG ASN A 1056 5.817 34.281 −58.739 1.00 25.17 C ATOM 7524 OD1 ASN A 1056 5.790 35.315 −59.387 1.00 27.55 O ATOM 7525 ND2 ASN A 1056 4.720 33.733 −58.209 1.00 25.07 N ATOM 7526 C ASN A 1056 8.321 31.515 −57.842 1.00 23.55 C ATOM 7527 O ASN A 1056 8.757 30.816 −58.762 1.00 24.11 O ATOM 7528 N ARG A 1057 8.999 31.745 −56.726 1.00 22.71 N ATOM 7529 CA ARG A 1057 10.302 31.164 −56.552 1.00 22.43 C ATOM 7530 CB ARG A 1057 11.131 31.994 −55.588 1.00 23.48 C ATOM 7531 CG ARG A 1057 11.492 33.344 −56.173 1.00 25.45 C ATOM 7532 CD ARG A 1057 12.110 34.303 −55.163 1.00 28.25 C ATOM 7533 NE ARG A 1057 12.019 35.686 −55.647 1.00 30.38 N ATOM 7534 CZ ARG A 1057 12.974 36.316 −56.334 1.00 31.48 C ATOM 7535 NH1 ARG A 1057 14.128 35.711 −56.609 1.00 32.14 N ATOM 7536 NH2 ARG A 1057 12.776 37.560 −56.745 1.00 32.02 N ATOM 7537 C ARG A 1057 10.172 29.704 −56.138 1.00 21.97 C ATOM 7538 O ARG A 1057 10.958 28.868 −56.573 1.00 21.88 O ATOM 7539 N LEU A 1058 9.147 29.387 −55.344 1.00 21.27 N ATOM 7540 CA LEU A 1058 8.825 27.985 −55.034 1.00 20.74 C ATOM 7541 CB LEU A 1058 7.737 27.870 −53.964 1.00 20.54 C ATOM 7542 CG LEU A 1058 8.105 27.734 −52.480 1.00 20.25 C ATOM 7543 CD1 LEU A 1058 6.830 27.842 −51.651 1.00 20.25 C ATOM 7544 CD2 LEU A 1058 8.868 26.453 −52.151 1.00 19.29 C ATOM 7545 C LEU A 1058 8.390 27.198 −56.269 1.00 20.41 C ATOM 7546 O LEU A 1058 8.598 25.985 −56.343 1.00 20.45 O ATOM 7547 N ASN A 1059 7.780 27.878 −57.235 1.00 19.62 N ATOM 7548 CA ASN A 1059 7.406 27.211 −58.470 1.00 19.09 C ATOM 7549 CB ASN A 1059 6.413 28.031 −59.272 1.00 18.30 C ATOM 7550 CG ASN A 1059 5.060 28.121 −58.590 1.00 17.84 C ATOM 7551 OD1 ASN A 1059 4.619 27.184 −57.932 1.00 17.18 O ATOM 7552 ND2 ASN A 1059 4.399 29.258 −58.740 1.00 18.08 N ATOM 7553 C ASN A 1059 8.586 26.740 −59.314 1.00 19.40 C ATOM 7554 O ASN A 1059 8.503 25.700 −59.942 1.00 20.17 O ATOM 7555 N LYS A 1060 9.690 27.480 −59.284 1.00 19.72 N ATOM 7556 CA LYS A 1060 10.910 27.095 −60.003 1.00 20.03 C ATOM 7557 CB LYS A 1060 11.927 28.234 −59.973 1.00 19.98 C ATOM 7558 CG LYS A 1060 11.444 29.551 −60.553 1.00 20.50 C ATOM 7559 CD LYS A 1060 12.581 30.558 −60.621 1.00 21.29 C ATOM 7560 CE LYS A 1060 12.237 31.741 −61.517 1.00 22.12 C ATOM 7561 NZ LYS A 1060 11.562 32.828 −60.754 1.00 23.27 N ATOM 7562 C LYS A 1060 11.554 25.827 −59.416 1.00 20.68 C ATOM 7563 O LYS A 1060 12.178 25.034 −60.130 1.00 20.26 O ATOM 7564 N VAL A 1061 11.385 25.645 −58.113 1.00 21.47 N ATOM 7565 CA VAL A 1061 12.057 24.588 −57.374 1.00 22.39 C ATOM 7566 CB VAL A 1061 12.450 25.103 −55.970 1.00 22.69 C ATOM 7567 CG1 VAL A 1061 12.772 23.960 −55.022 1.00 23.52 C ATOM 7568 CG2 VAL A 1061 13.628 26.052 −56.070 1.00 23.00 C ATOM 7569 C VAL A 1061 11.249 23.272 −57.284 1.00 23.41 C ATOM 7570 O VAL A 1061 11.803 22.190 −57.473 1.00 23.89 O ATOM 7571 N ILE A 1062 9.951 23.362 −56.996 1.00 24.06 N ATOM 7572 CA ILE A 1062 9.141 22.161 −56.743 1.00 24.77 C ATOM 7573 CB ILE A 1062 7.836 22.497 −55.998 1.00 23.31 C ATOM 7574 CG1 ILE A 1062 8.162 22.951 −54.575 1.00 22.64 C ATOM 7575 CD1 ILE A 1062 7.002 23.566 −53.841 1.00 22.21 C ATOM 7576 CG2 ILE A 1062 6.906 21.294 −55.995 1.00 22.19 C ATOM 7577 C ILE A 1062 8.803 21.411 −58.021 1.00 26.59 C ATOM 7578 O ILE A 1062 8.440 22.030 −59.025 1.00 27.80 O ATOM 7579 N LYS A 1063 8.929 20.081 −57.973 1.00 27.74 N ATOM 7580 CA LYS A 1063 8.562 19.207 −59.098 1.00 28.21 C ATOM 7581 CB LYS A 1063 9.413 17.907 −59.107 1.00 29.80 C ATOM 7582 CG LYS A 1063 8.757 16.723 −59.842 1.00 32.05 C ATOM 7583 CD LYS A 1063 9.704 15.920 −60.753 1.00 31.74 C ATOM 7584 CE LYS A 1063 9.006 15.443 −62.040 1.00 30.05 C ATOM 7585 NZ LYS A 1063 7.657 14.820 −61.848 1.00 27.71 N ATOM 7586 C LYS A 1063 7.071 18.890 −59.036 1.00 26.78 C ATOM 7587 O LYS A 1063 6.591 18.395 −58.025 1.00 27.60 O ATOM 7588 N SER A 1064 6.342 19.189 −60.110 1.00 25.12 N ATOM 7589 CA SER A 1064 4.903 18.909 −60.149 1.00 23.81 C ATOM 7590 CB SER A 1064 4.112 20.124 −60.634 1.00 22.63 C ATOM 7591 OG SER A 1064 3.884 20.069 −62.027 1.00 21.91 O ATOM 7592 C SER A 1064 4.623 17.696 −61.029 1.00 23.38 C ATOM 7593 O SER A 1064 5.255 17.531 −62.079 1.00 23.01 O ATOM 7594 N VAL A 1065 3.651 16.878 −60.619 1.00 22.64 N ATOM 7595 CA VAL A 1065 3.551 15.505 −61.115 1.00 22.14 C ATOM 7596 CB VAL A 1065 2.503 14.663 −61.357 1.00 21.13 C ATOM 7597 CG1 VAL A 1065 2.010 13.495 −61.192 1.00 20.60 C ATOM 7598 CG2 VAL A 1065 3.122 14.134 −59.077 1.00 20.61 C ATOM 7599 C VAL A 1065 3.507 15.337 −62.642 1.00 23.08 C ATOM 7600 O VAL A 1065 4.386 14.676 −63.208 1.00 24.48 O ATOM 7601 N GLY A 1066 2.533 15.936 −63.318 1.00 22.54 N ATOM 7602 CA GLY A 1066 2.489 15.820 −64.787 1.00 21.43 C ATOM 7603 C GLY A 1066 3.274 16.919 −65.490 1.00 20.83 C ATOM 7604 O GLY A 1066 3.009 17.230 −66.667 1.00 20.98 O ATOM 7605 N LYS A 1067 4.236 17.504 −64.768 1.00 19.54 N ATOM 7606 CA LYS A 1067 4.927 18.731 −65.195 1.00 18.80 C ATOM 7607 CB LYS A 1067 5.982 18.439 −66.277 1.00 18.99 C ATOM 7608 CG LYS A 1067 7.220 17.722 −65.753 1.00 19.21 C ATOM 7609 CD LYS A 1067 8.162 17.333 −66.877 1.00 19.52 C ATOM 7610 CE LYS A 1067 9.531 16.971 −66.320 1.00 20.16 C ATOM 7611 NZ LYS A 1067 10.346 16.156 −67.269 1.00 20.47 N ATOM 7612 C LYS A 1067 3.958 19.840 −65.637 1.00 17.84 C ATOM 7613 O LYS A 1067 4.125 20.438 −66.687 1.00 17.47 O ATOM 7614 N ILE A 1068 2.943 20.092 −64.820 1.00 17.12 N ATOM 7615 CA ILE A 1068 2.005 21.181 −65.055 1.00 16.72 C ATOM 7616 CB ILE A 1068 0.568 20.776 −64.668 1.00 16.45 C ATOM 7617 CG1 ILE A 1068 0.216 19.420 −65.282 1.00 16.00 C ATOM 7618 CD1 ILE A 1068 −1.107 18.870 −64.805 1.00 16.20 C ATOM 7619 CG2 ILE A 1068 −0.431 21.861 −65.072 1.00 16.13 C ATOM 7620 C ILE A 1068 2.403 22.410 −64.251 1.00 16.65 C ATOM 7621 O ILE A 1068 2.661 22.326 −63.060 1.00 16.36 O ATOM 7622 N GLU A 1069 2.436 23.552 −64.916 1.00 17.16 N ATOM 7623 CA GLU A 1069 2.786 24.805 −64.281 1.00 17.77 C ATOM 7624 CB GLU A 1069 2.972 25.871 −65.355 1.00 19.98 C ATOM 7625 CG GLU A 1069 4.204 25.675 −66.223 1.00 23.06 C ATOM 7626 CD GLU A 1069 5.385 26.529 −65.774 1.00 26.20 C ATOM 7627 OE1 GLU A 1069 5.823 26.391 −64.596 1.00 26.45 O ATOM 7628 OE2 GLU A 1069 5.871 27.350 −66.611 1.00 28.65 O ATOM 7629 C GLU A 1069 1.721 25.265 −63.266 1.00 17.00 C ATOM 7630 O GLU A 1069 0.553 25.479 −63.634 1.00 17.06 O ATOM 7631 N HIS A 1070 2.124 25.431 −61.998 1.00 15.25 N ATOM 7632 CA HIS A 1070 1.249 25.996 −60.967 1.00 13.96 C ATOM 7633 CB HIS A 1070 2.063 26.456 −59.769 1.00 13.83 C ATOM 7634 CG HIS A 1070 1.226 26.966 −58.624 1.00 13.78 C ATOM 7635 ND1 HIS A 1070 0.983 28.281 −58.431 1.00 13.79 N ATOM 7636 CE1 HIS A 1070 0.189 28.434 −57.353 1.00 13.71 C ATOM 7637 NE2 HIS A 1070 −0.085 27.211 −56.858 1.00 13.74 N ATOM 7638 CD2 HIS A 1070 0.540 26.284 −57.614 1.00 13.56 C ATOM 7639 C HIS A 1070 0.395 27.123 −61.484 1.00 13.43 C ATOM 7640 O HIS A 1070 −0.801 27.164 −61.247 1.00 12.80 O ATOM 7641 N SER A 1071 1.013 28.035 −62.221 1.00 13.43 N ATOM 7642 CA SER A 1071 0.320 29.176 −62.818 1.00 13.53 C ATOM 7643 CB SER A 1071 1.301 29.982 −63.639 1.00 13.24 C ATOM 7644 OG SER A 1071 1.520 31.197 −62.986 1.00 13.47 O ATOM 7645 C SER A 1071 −0.863 28.806 −63.704 1.00 13.62 C ATOM 7646 O SER A 1071 −1.892 29.499 −63.741 1.00 13.34 O ATOM 7647 N PHE A 1072 −0.687 27.722 −64.442 1.00 13.62 N ATOM 7648 CA PHE A 1072 −1.690 27.270 −65.358 1.00 13.70 C ATOM 7649 CB PHE A 1072 −1.090 26.219 −66.292 1.00 13.71 C ATOM 7650 CG PHE A 1072 −2.081 25.597 −67.197 1.00 13.67 C ATOM 7651 CD1 PHE A 1072 −2.587 26.309 −68.275 1.00 13.50 C ATOM 7652 CE1 PHE A 1072 −3.531 25.738 −69.111 1.00 13.91 C ATOM 7653 CZ PHE A 1072 −3.974 24.439 −68.877 1.00 14.23 C ATOM 7654 CE2 PHE A 1072 −3.475 23.718 −67.794 1.00 14.21 C ATOM 7655 CD2 PHE A 1072 −2.533 24.301 −66.958 1.00 13.81 C ATOM 7656 C PHE A 1072 −2.859 26.707 −64.559 1.00 13.78 C ATOM 7657 O PHE A 1072 −4.021 26.957 −64.884 1.00 14.11 O ATOM 7658 N TRP A 1073 −2.525 25.977 −63.495 1.00 13.55 N ATOM 7659 CA TRP A 1073 −3.493 25.356 −62.591 1.00 13.20 C ATOM 7660 CB TRP A 1073 −2.729 24.497 −61.584 1.00 12.86 C ATOM 7661 CG TRP A 1073 −3.488 23.958 −60.388 1.00 12.64 C ATOM 7662 CD1 TRP A 1073 −3.093 24.003 −59.041 1.00 12.50 C ATOM 7663 NE1 TRP A 1073 −4.018 23.382 −58.232 1.00 12.25 N ATOM 7664 CE2 TRP A 1073 −5.042 22.892 −58.977 1.00 12.39 C ATOM 7665 CD2 TRP A 1073 −4.758 23.221 −60.385 1.00 12.38 C ATOM 7666 CE3 TRP A 1073 −5.664 22.840 −61.357 1.00 12.09 C ATOM 7667 CZ3 TRP A 1073 −6.816 22.148 −60.962 1.00 11.82 C ATOM 7668 CH2 TRP A 1073 −7.067 21.841 −59.628 1.00 11.94 C ATOM 7669 CZ2 TRP A 1073 −6.187 22.206 −58.605 1.00 12.22 C ATOM 7670 C TRP A 1073 −4.373 26.380 −61.927 1.00 13.32 C ATOM 7671 O TRP A 1073 −5.589 26.300 −62.029 1.00 13.33 O ATOM 7672 N ARG A 1074 −3.771 27.387 −61.296 1.00 13.77 N ATOM 7673 CA ARG A 1074 −4.530 28.365 −60.502 1.00 14.41 C ATOM 7674 CB ARG A 1074 −3.655 28.986 −59.415 1.00 14.02 C ATOM 7675 CG ARG A 1074 −3.224 28.008 −58.336 1.00 13.84 C ATOM 7676 CD ARG A 1074 −4.353 27.064 −57.955 1.00 13.55 C ATOM 7677 NE ARG A 1074 −4.079 26.430 −56.673 1.00 13.40 N ATOM 7678 CZ ARG A 1074 −4.977 25.779 −55.954 1.00 12.99 C ATOM 7679 NH1 ARG A 1074 −6.222 25.669 −56.381 1.00 13.08 N ATOM 7680 NH2 ARG A 1074 −4.629 25.254 −54.804 1.00 12.88 N ATOM 7681 C ARG A 1074 −5.216 29.458 −61.318 1.00 15.26 C ATOM 7682 O ARG A 1074 −6.027 30.234 −60.781 1.00 14.96 O ATOM 7683 N SER A 1075 −4.893 29.497 −62.610 1.00 16.29 N ATOM 7684 CA SER A 1075 −5.442 30.454 −63.531 1.00 17.54 C ATOM 7685 CB SER A 1075 −4.833 30.208 −64.895 1.00 17.91 C ATOM 7686 OG SER A 1075 −4.316 31.406 −65.446 1.00 19.24 O ATOM 7687 C SER A 1075 −6.960 30.294 −63.595 1.00 18.86 C ATOM 7688 O SER A 1075 −7.463 29.203 −63.850 1.00 19.53 O ATOM 7689 N PHE A 1076 −7.686 31.375 −63.315 1.00 20.22 N ATOM 7690 CA PHE A 1076 −9.146 31.400 −63.422 1.00 21.15 C ATOM 7691 CB PHE A 1076 −9.630 32.840 −63.212 1.00 21.10 C ATOM 7692 CG PHE A 1076 −11.116 33.041 −63.398 1.00 21.25 C ATOM 7693 CD1 PHE A 1076 −11.696 33.006 −64.679 1.00 20.92 C ATOM 7694 CE1 PHE A 1076 −13.058 33.217 −64.850 1.00 20.26 C ATOM 7695 CZ PHE A 1076 −13.856 33.492 −63.743 1.00 20.61 C ATOM 7696 CE2 PHE A 1076 −13.296 33.544 −62.468 1.00 20.56 C ATOM 7697 CD2 PHE A 1076 −11.934 33.334 −62.299 1.00 20.90 C ATOM 7698 C PHE A 1076 −9.568 30.845 −64.790 1.00 22.49 C ATOM 7699 O PHE A 1076 −9.033 31.255 −65.830 1.00 22.71 O ATOM 7700 N HIS A 1077 −10.524 29.917 −64.783 1.00 24.61 N ATOM 7701 CA HIS A 1077 −10.825 29.070 −65.960 1.00 26.47 C ATOM 7702 CB HIS A 1077 −10.183 27.689 −65.754 1.00 28.32 C ATOM 7703 CG HIS A 1077 −10.555 26.660 −66.811 1.00 30.35 C ATOM 7704 ND1 HIS A 1077 −10.239 26.808 −68.124 1.00 31.52 N ATOM 7705 CE1 HIS A 1077 −10.688 25.741 −68.816 1.00 31.37 C ATOM 7706 NE2 HIS A 1077 −11.283 24.900 −67.947 1.00 31.98 N ATOM 7707 CD2 HIS A 1077 −11.215 25.433 −66.703 1.00 30.85 C ATOM 7708 C HIS A 1077 −12.297 28.904 −66.263 1.00 26.24 C ATOM 7709 O HIS A 1077 −13.103 28.715 −65.366 1.00 24.84 O ATOM 7710 N THR A 1078 −12.661 28.963 −67.538 1.00 28.55 N ATOM 7711 CA THR A 1078 −14.008 28.521 −67.961 1.00 30.31 C ATOM 7712 CB THR A 1078 −14.979 29.705 −68.229 1.00 30.23 C ATOM 7713 OG1 THR A 1078 −14.536 30.468 −69.360 1.00 31.54 O ATOM 7714 CG2 THR A 1078 −15.078 30.608 −67.009 1.00 29.60 C ATOM 7715 C THR A 1078 −14.017 27.521 −69.144 1.00 30.30 C ATOM 7716 O THR A 1078 −13.104 27.499 −69.981 1.00 29.83 O ATOM 7717 N LYS A 1081 −12.811 30.972 −71.684 1.00 50.00 N ATOM 7718 CA LYS A 1081 −11.960 32.028 −71.127 1.00 48.46 C ATOM 7719 CB LYS A 1081 −12.810 33.140 −70.490 1.00 45.99 C ATOM 7720 C LYS A 1081 −10.940 31.494 −70.110 1.00 48.69 C ATOM 7721 O LYS A 1081 −11.222 30.539 −69.357 1.00 46.95 O ATOM 7722 N THR A 1082 −9.754 32.118 −70.111 1.00 46.37 N ATOM 7723 CA THR A 1082 −8.695 31.857 −69.118 1.00 42.00 C ATOM 7724 CB THR A 1082 −7.761 30.700 −69.553 1.00 42.10 C ATOM 7725 OG1 THR A 1082 −8.368 29.449 −69.192 1.00 43.06 O ATOM 7726 CG2 THR A 1082 −6.366 30.803 −68.895 1.00 39.48 C ATOM 7727 C THR A 1082 −7.904 33.128 −68.824 1.00 39.27 C ATOM 7728 O THR A 1082 −7.475 33.830 −69.741 1.00 39.77 O ATOM 7729 N GLU A 1083 −7.748 33.423 −67.535 1.00 36.33 N ATOM 7730 CA GLU A 1083 −7.011 34.598 −67.061 1.00 32.57 C ATOM 7731 CB GLU A 1083 −7.975 35.692 −66.608 1.00 34.84 C ATOM 7732 CG GLU A 1083 −7.475 33.830 −69.741 1.00 39.77 C ATOM 7733 CD GLU A 1083 −9.562 37.552 −67.190 1.00 40.78 C ATOM 7734 OE1 GLU A 1083 −9.477 37.978 −66.015 1.00 41.65 O ATOM 7735 OE2 GLU A 1083 −10.509 37.853 −67.951 1.00 43.01 O ATOM 7736 C GLU A 1083 −6.151 34.195 −65.880 1.00 28.26 C ATOM 7737 O GLU A 1083 −6.506 33.279 −65.137 1.00 27.38 O ATOM 7738 N PRO A 1084 −5.022 34.884 −65.686 1.00 25.81 N ATOM 7739 CA PRO A 1084 −4.139 34.542 −64.562 1.00 24.29 C ATOM 7740 CB PRO A 1084 −2.961 35.497 −64.735 1.00 23.94 C ATOM 7741 CG PRO A 1084 −2.986 35.861 −66.180 1.00 24.84 C ATOM 7742 CD PRO A 1084 −4.431 35.905 −66.560 1.00 25.20 C ATOM 7743 C PRO A 1084 −4.802 34.752 −63.199 1.00 22.30 C ATOM 7744 O PRO A 1084 −5.676 35.612 −63.058 1.00 22.29 O ATOM 7745 N ALA A 1085 −4.395 33.946 −62.218 1.00 20.07 N ATOM 7746 CA ALA A 1085 −4.841 34.103 −60.834 1.00 18.00 C ATOM 7747 CB ALA A 1085 −4.247 33.012 −59.952 1.00 17.35 C ATOM 7748 C ALA A 1085 −4.438 35.472 −60.324 1.00 16.99 C ATOM 7749 O ALA A 1085 −3.501 36.101 −60.833 1.00 16.01 O ATOM 7750 N THR A 1086 −5.153 35.942 −59.319 1.00 16.23 N ATOM 7751 CA THR A 1086 −4.863 37.252 −58.780 1.00 15.67 C ATOM 7752 CB THR A 1086 −5.203 38.357 −59.808 1.00 15.86 C ATOM 7753 OG1 THR A 1086 −4.428 39.521 −59.516 1.00 16.98 O ATOM 7754 CG2 THR A 1086 −6.704 38.700 −59.834 1.00 16.00 C ATOM 7755 C THR A 1086 −5.514 37.485 −57.418 1.00 14.86 C ATOM 7756 O THR A 1086 −6.603 36.983 −57.147 1.00 14.60 O ATOM 7757 N GLY A 1087 −4.812 38.200 −56.547 1.00 14.27 N ATOM 7758 CA GLY A 1087 −5.324 38.507 −55.206 1.00 14.16 C ATOM 7759 C GLY A 1087 −5.567 37.306 −54.313 1.00 13.99 C ATOM 7760 O GLY A 1087 −6.234 37.408 −53.287 1.00 14.22 O ATOM 7761 N PHE A 1088 −5.041 36.158 −54.714 1.00 13.92 N ATOM 7762 CA PHE A 1088 −5.155 34.944 −53.919 1.00 13.90 C ATOM 7763 CB PHE A 1088 −6.135 33.955 −54.572 1.00 13.94 C ATOM 7764 CG PHE A 1088 −7.568 34.201 −54.228 1.00 13.75 C ATOM 7765 CD1 PHE A 1088 −8.103 33.707 −53.052 1.00 13.70 C ATOM 7766 CE1 PHE A 1088 −9.431 33.931 −52.726 1.00 13.78 C ATOM 7767 CZ PHE A 1088 −10.244 34.652 −53.586 1.00 13.89 C ATOM 7768 CE2 PHE A 1088 −9.722 35.151 −54.767 1.00 13.85 C ATOM 7769 CD2 PHE A 1088 −8.387 34.924 −55.083 1.00 13.84 C ATOM 7770 C PHE A 1088 −3.799 34.277 −53.781 1.00 13.60 C ATOM 7771 O PHE A 1088 −3.061 34.170 −54.765 1.00 13.27 O ATOM 7772 N ILE A 1089 −3.494 33.816 −52.568 1.00 13.32 N ATOM 7773 CA ILE A 1089 −2.296 33.024 −52.316 1.00 13.36 C ATOM 7774 CB ILE A 1089 −1.454 33.649 −51.207 1.00 13.27 C ATOM 7775 CG1 ILE A 1089 −0.780 34.898 −51.750 1.00 13.50 C ATOM 7776 CD1 ILE A 1089 −0.442 35.893 −50.673 1.00 13.99 C ATOM 7777 CG2 ILE A 1089 −0.424 32.659 −50.688 1.00 13.15 C ATOM 7778 C ILE A 1089 −2.615 31.565 −51.983 1.00 13.33 C ATOM 7779 O ILE A 1089 −3.377 31.275 −51.048 1.00 13.25 O ATOM 7780 N ASP A 1090 −2.036 30.659 −52.770 1.00 13.07 N ATOM 7781 CA ASP A 1090 −2.194 29.232 −52.567 1.00 13.03 C ATOM 7782 CB ASP A 1090 −1.807 28.450 −53.823 1.00 13.15 C ATOM 7783 CG ASP A 1090 −2.032 26.966 −53.668 1.00 13.56 C ATOM 7784 OD1 ASP A 1090 −2.856 26.593 −52.814 1.00 14.57 O ATOM 7785 OD2 ASP A 1090 −1.395 26.161 −54.367 1.00 13.45 O ATOM 7786 C ASP A 1090 −1.358 28.773 −51.380 1.00 13.07 C ATOM 7787 O ASP A 1090 −0.195 28.405 −51.530 1.00 13.24 O ATOM 7788 N GLY A 1091 −1.969 28.789 −50.201 1.00 13.03 N ATOM 7789 CA GLY A 1091 −1.316 28.374 −48.973 1.00 12.82 C ATOM 7790 C GLY A 1091 −0.897 26.928 −49.027 1.00 13.00 C ATOM 7791 O GLY A 1091 0.024 26.526 −48.321 1.00 13.01 O ATOM 7792 N ASP A 1092 −1.577 26.136 −49.857 1.00 13.20 N ATOM 7793 CA ASP A 1092 −1.174 24.756 −50.073 1.00 13.39 C ATOM 7794 CB ASP A 1092 −2.124 24.048 −51.032 1.00 14.10 C ATOM 7795 CG ASP A 1092 −3.322 23.415 −50.320 1.00 14.70 C ATOM 7796 OD1 ASP A 1092 −3.625 23.819 −49.183 1.00 15.73 O ATOM 7797 OD2 ASP A 1092 −3.961 22.506 −50.890 1.00 14.40 O ATOM 7798 C ASP A 1092 0.229 24.751 −50.631 1.00 13.56 C ATOM 7799 O ASP A 1092 1.083 23.998 −50.160 1.00 14.03 O ATOM 7800 N LEU A 1093 0.480 25.620 −51.611 1.00 13.43 N ATOM 7801 CA LEU A 1093 1.827 25.800 −52.161 1.00 13.17 C ATOM 7802 CB LEU A 1093 1.796 26.633 −53.441 1.00 13.01 C ATOM 7803 CG LEU A 1093 3.165 26.961 −54.042 1.00 12.83 C ATOM 7804 CD1 LEU A 1093 3.905 25.696 −54.450 1.00 12.79 C ATOM 7805 CD2 LEU A 1093 3.000 27.915 −55.212 1.00 12.93 C ATOM 7806 C LEU A 1093 2.833 26.403 −51.171 1.00 13.13 C ATOM 7807 O LEU A 1093 3.953 25.896 −51.042 1.00 13.44 O ATOM 7808 N ILE A 1094 2.455 27.494 −50.504 1.00 12.71 N ATOM 7809 CA ILE A 1094 3.342 28.118 −49.517 1.00 12.54 C ATOM 7810 CB ILE A 1094 2.702 29.365 −48.864 1.00 12.27 C ATOM 7811 CG1 ILE A 1094 2.521 30.483 −49.896 1.00 12.12 C ATOM 7812 CD1 ILE A 1094 3.805 31.059 −50.439 1.00 12.14 C ATOM 7813 CG2 ILE A 1094 3.520 29.849 −47.671 1.00 12.20 C ATOM 7814 C ILE A 1094 3.814 27.124 −48.447 1.00 12.62 C ATOM 7815 O ILE A 1094 4.988 27.087 −48.113 1.00 12.21 O ATOM 7816 N GLU A 1095 2.905 26.294 −47.945 1.00 13.23 N ATOM 7817 CA GLU A 1095 3.242 25.380 −46.853 1.00 13.72 C ATOM 7818 CB GLU A 1095 1.986 24.801 −46.194 1.00 14.72 C ATOM 7819 CG GLU A 1095 1.428 25.768 −45.152 1.00 16.66 C ATOM 7820 CD GLU A 1095 −0.005 25.477 −44.690 1.00 17.88 C ATOM 7821 OE1 GLU A 1095 −0.378 24.272 −44.602 1.00 18.12 O ATOM 7822 OE2 GLU A 1095 −0.745 26.473 −44.394 1.00 17.82 O ATOM 7823 C GLU A 1095 4.252 24.309 −47.224 1.00 13.12 C ATOM 7824 O GLU A 1095 5.001 23.850 −46.373 1.00 12.96 O ATOM 7825 N SER A 1096 4.301 23.941 −48.497 1.00 12.84 N ATOM 7826 CA SER A 1096 5.295 22.985 −48.957 1.00 12.86 C ATOM 7827 CB SER A 1096 4.978 22.519 −50.370 1.00 12.91 C ATOM 7828 OG SER A 1096 5.208 23.552 −51.299 1.00 13.20 O ATOM 7829 C SER A 1096 6.742 23.511 −48.866 1.00 12.94 C ATOM 7830 O SER A 1096 7.686 22.730 −48.916 1.00 13.08 O ATOM 7831 N PHE A 1097 6.916 24.822 −48.713 1.00 13.02 N ATOM 7832 CA PHE A 1097 8.240 25.392 −48.428 1.00 13.13 C ATOM 7833 CB PHE A 1097 8.140 26.867 −48.015 1.00 12.88 C ATOM 7834 CG PHE A 1097 9.434 27.459 −47.522 1.00 12.76 C ATOM 7835 CD1 PHE A 1097 10.425 27.855 −48.413 1.00 12.87 C ATOM 7836 CE1 PHE A 1097 11.614 28.406 −47.961 1.00 12.55 C ATOM 7837 CZ PHE A 1097 11.819 28.575 −46.603 1.00 12.62 C ATOM 7838 CE2 PHE A 1097 10.845 28.186 −45.705 1.00 12.63 C ATOM 7839 CD2 PHE A 1097 9.659 27.635 −46.166 1.00 12.69 C ATOM 7840 C PHE A 1097 8.980 24.609 −47.360 1.00 13.53 C ATOM 7841 O PHE A 1097 10.201 24.517 −47.406 1.00 13.79 O ATOM 7842 N LEU A 1098 8.239 24.044 −46.406 1.00 14.27 N ATOM 7843 CA LEU A 1098 8.829 23.348 −45.253 1.00 15.01 C ATOM 7844 CB LEU A 1098 7.796 23.143 −44.156 1.00 14.51 C ATOM 7845 CG LEU A 1098 7.249 24.433 −43.581 1.00 14.60 C ATOM 7846 CD1 LEU A 1098 5.979 24.141 −42.797 1.00 14.79 C ATOM 7847 CD2 LEU A 1098 8.299 25.140 −42.732 1.00 14.37 C ATOM 7848 C LEU A 1098 9.445 22.007 −45.619 1.00 15.80 C ATOM 7849 O LEU A 1098 10.334 21.509 −44.927 1.00 16.53 O ATOM 7850 N ASP A 1099 8.992 21.435 −46.718 1.00 16.18 N ATOM 7851 CA ASP A 1099 9.408 20.113 −47.059 1.00 17.20 C ATOM 7852 CB ASP A 1099 8.190 19.305 −47.543 1.00 18.36 C ATOM 7853 CG ASP A 1099 7.124 19.102 −46.412 1.00 19.84 C ATOM 7854 OD1 ASP A 1099 7.521 18.793 −45.252 1.00 20.26 O ATOM 7855 OD2 ASP A 1099 5.897 19.262 −46.672 1.00 19.98 O ATOM 7856 C ASP A 1099 10.610 20.079 −48.025 1.00 17.56 C ATOM 7857 O ASP A 1099 11.192 19.026 −48.236 1.00 18.09 O ATOM 7858 N ILE A 1100 11.010 21.224 −48.578 1.00 17.87 N ATOM 7859 CA ILE A 1100 12.160 21.264 −49.509 1.00 18.52 C ATOM 7860 CB ILE A 1100 12.091 22.441 −50.535 1.00 18.36 C ATOM 7861 CG1 ILE A 1100 12.307 23.802 −49.856 1.00 18.11 C ATOM 7862 CD1 ILE A 1100 12.196 24.991 −50.786 1.00 18.22 C ATOM 7863 CG2 ILE A 1100 10.787 22.414 −51.327 1.00 18.01 C ATOM 7864 C ILE A 1100 13.509 21.260 −48.764 1.00 19.48 C ATOM 7865 O ILE A 1100 13.559 21.529 −47.562 1.00 19.64 O ATOM 7866 N SER A 1101 14.594 20.957 −49.485 1.00 20.72 N ATOM 7867 CA SER A 1101 15.931 20.813 −48.878 1.00 21.82 C ATOM 7868 CB SER A 1101 16.897 20.103 −49.835 1.00 22.16 C ATOM 7869 OG SER A 1101 17.446 21.001 −50.781 1.00 22.13 O ATOM 7870 C SER A 1101 16.521 22.154 −48.474 1.00 22.33 C ATOM 7871 O SER A 1101 16.295 23.155 −49.140 1.00 23.44 O ATOM 7872 N ARG A 1102 17.304 22.163 −47.403 1.00 22.61 N ATOM 7873 CA ARG A 1102 17.886 23.404 −46.891 1.00 23.06 C ATOM 7874 CB ARG A 1102 18.915 23.111 −45.784 1.00 23.77 C ATOM 7875 CG ARG A 1102 19.447 24.339 −45.073 1.00 24.58 C ATOM 7876 CD ARG A 1102 18.475 24.840 −44.023 1.00 26.60 C ATOM 7877 NE ARG A 1102 19.027 25.975 −43.284 1.00 28.86 N ATOM 7878 CZ ARG A 1102 18.423 26.593 −42.263 1.00 29.92 C ATOM 7879 NH1 ARG A 1102 17.221 26.190 −41.827 1.00 28.81 N ATOM 7880 NH2 ARG A 1102 19.030 27.625 −41.674 1.00 29.84 N ATOM 7881 C ARG A 1102 18.470 24.308 −47.998 1.00 22.56 C ATOM 7882 O ARG A 1102 18.228 25.512 −47.986 1.00 21.25 O ATOM 7883 N PRO A 1103 19.241 23.730 −48.953 1.00 23.49 N ATOM 7884 CA PRO A 1103 19.748 24.564 −50.066 1.00 24.07 C ATOM 7885 CB PRO A 1103 20.631 23.600 −50.877 1.00 23.98 C ATOM 7886 CG PRO A 1103 20.407 22.239 −50.294 1.00 23.89 C ATOM 7887 CD PRO A 1103 19.939 22.431 −48.890 1.00 23.33 C ATOM 7888 C PRO A 1103 18.655 25.165 −50.956 1.00 24.11 C ATOM 7889 O PRO A 1103 18.807 26.287 −51.450 1.00 24.52 O ATOM 7890 N LYS A 1104 17.572 24.421 −51.153 1.00 23.77 N ATOM 7891 CA LYS A 1104 16.439 24.911 −51.915 1.00 23.95 C ATOM 7892 CB LYS A 1104 15.508 23.758 −52.300 1.00 25.24 C ATOM 7893 CG LYS A 1104 16.138 22.658 −53.153 1.00 26.74 C ATOM 7894 CD LYS A 1104 16.899 23.196 −54.360 1.00 28.54 C ATOM 7895 CE LYS A 1104 16.038 23.303 −55.611 1.00 29.55 C ATOM 7896 NZ LYS A 1104 16.594 24.290 −56.593 1.00 29.88 N ATOM 7897 C LYS A 1104 15.666 26.012 −51.169 1.00 23.61 C ATOM 7898 O LYS A 1104 15.230 26.979 −51.788 1.00 23.72 O ATOM 7899 N MET A 1105 15.495 25.860 −49.850 1.00 23.37 N ATOM 7900 CA MET A 1105 14.924 26.920 −49.008 1.00 23.10 C ATOM 7901 CB MET A 1105 14.958 26.559 −47.527 1.00 21.94 C ATOM 7902 CG MET A 1105 14.052 25.426 −47.095 1.00 21.99 C ATOM 7903 SD MET A 1105 13.826 25.385 −45.300 1.00 21.66 S ATOM 7904 CE MET A 1105 14.050 23.630 −44.980 1.00 22.82 C ATOM 7905 C MET A 1105 15.687 28.215 −49.202 1.00 24.47 C ATOM 7906 O MET A 1105 15.086 29.274 −49.343 1.00 24.93 O ATOM 7907 N GLN A 1106 17.016 28.136 −49.209 1.00 26.69 N ATOM 7908 CA GLN A 1106 17.810 29.344 −49.378 1.00 28.53 C ATOM 7909 CB GLN A 1106 19.228 29.198 −48.876 1.00 30.06 C ATOM 7910 CG GLN A 1106 19.782 30.549 −48.458 1.00 32.31 C ATOM 7911 CD GLN A 1106 19.431 30.894 −47.017 1.00 35.13 C ATOM 7912 OE1 GLN A 1106 19.403 30.010 −46.151 1.00 36.66 O ATOM 7913 NE2 GLN A 1106 19.186 32.182 −46.744 1.00 34.65 N ATOM 7914 C GLN A 1106 17.833 29.834 −50.802 1.00 29.07 C ATOM 7915 O GLN A 1106 17.791 31.043 −51.031 1.00 29.68 O ATOM 7916 N GLU A 1107 17.903 28.902 −51.753 1.00 29.17 N ATOM 7917 CA GLU A 1107 17.797 29.238 −53.166 1.00 29.07 C ATOM 7918 CB GLU A 1107 17.391 28.021 −53.979 1.00 29.83 C ATOM 7919 CG GLU A 1107 17.581 28.188 −55.474 1.00 31.51 C ATOM 7920 CD GLU A 1107 18.381 27.047 −56.080 1.00 33.82 C ATOM 7921 OE1 GLU A 1107 18.473 26.990 −57.321 1.00 35.18 O ATOM 7922 OE2 GLU A 1107 18.934 26.207 −55.321 1.00 35.03 O ATOM 7923 C GLU A 1107 16.780 30.335 −53.371 1.00 28.97 C ATOM 7924 O GLU A 1107 17.083 31.364 −53.970 1.00 28.72 O ATOM 7925 N ASN A 1108 15.585 30.135 −52.827 1.00 29.56 N ATOM 7926 CA ASN A 1108 14.468 30.991 −53.170 1.00 30.95 C ATOM 7927 CB ASN A 1108 13.296 30.150 −53.684 1.00 31.87 C ATOM 7928 CG ASN A 1108 12.616 29.372 −52.593 1.00 32.21 C ATOM 7929 OD1 ASN A 1108 11.979 29.949 −51.707 1.00 32.45 O ATOM 7930 ND2 ASN A 1108 12.724 28.047 −52.660 1.00 33.01 N ATOM 7931 C ASN A 1108 14.020 32.040 −52.139 1.00 30.66 C ATOM 7932 O ASN A 1108 13.052 32.759 −52.370 1.00 30.82 O ATOM 7933 N VAL A 1109 14.726 32.150 −51.021 1.00 30.93 N ATOM 7934 CA VAL A 1109 14.584 33.350 −50.182 1.00 31.54 C ATOM 7935 CB VAL A 1109 14.549 33.027 −48.669 1.00 31.14 C ATOM 7936 CG1 VAL A 1109 13.386 32.100 −48.362 1.00 31.01 C ATOM 7937 CG2 VAL A 1109 15.858 32.410 −48.195 1.00 30.93 C ATOM 7938 C VAL A 1109 15.675 34.377 −50.513 1.00 32.25 C ATOM 7939 O VAL A 1109 15.884 35.330 −49.775 1.00 32.10 O ATOM 7940 N ALA A 1110 16.339 34.169 −51.654 1.00 34.69 N ATOM 7941 CA ALA A 1110 17.505 34.952 −52.089 1.00 34.94 C ATOM 7942 CB ALA A 1110 18.108 34.345 −53.349 1.00 33.53 C ATOM 7943 C ALA A 1110 17.193 36.420 −52.314 1.00 35.64 C ATOM 7944 O ALA A 1110 17.962 37.288 −51.924 1.00 34.43 O ATOM 7945 N ASN A 1111 16.063 36.694 −52.948 1.00 39.84 N ATOM 7946 CA ASN A 1111 15.674 38.072 −53.225 1.00 44.48 C ATOM 7947 CB ASN A 1111 15.724 38.353 −54.739 1.00 46.42 C ATOM 7948 CG ASN A 1111 17.063 37.971 −55.367 1.00 46.69 C ATOM 7949 OD1 ASN A 1111 17.161 36.972 −56.086 1.00 46.01 O ATOM 7950 ND2 ASN A 1111 18.102 38.762 −55.089 1.00 46.02 N ATOM 7951 C ASN A 1111 14.302 38.421 −52.623 1.00 45.28 C ATOM 7952 O ASN A 1111 13.378 38.839 −53.331 1.00 47.23 O ATOM 7953 N LEU A 1112 14.180 38.240 −51.310 1.00 43.07 N ATOM 7954 CA LEU A 1112 12.941 38.545 −50.612 1.00 43.33 C ATOM 7955 CB LEU A 1112 12.303 37.271 −50.050 1.00 43.37 C ATOM 7956 CG LEU A 1112 12.011 36.107 −50.994 1.00 44.43 C ATOM 7957 CD1 LEU A 1112 11.229 35.027 −50.261 1.00 43.36 C ATOM 7958 CD2 LEU A 1112 11.252 36.578 −52.227 1.00 44.79 C ATOM 7959 C LEU A 1112 13.150 39.559 −49.490 1.00 43.56 C ATOM 7960 O LEU A 1112 13.993 39.360 −49.609 1.00 42.72 O ATOM 7961 N GLN A 1113 12.377 40.643 −49.526 1.00 43.01 N ATOM 7962 CA GLN A 1113 12.413 41.632 −48.465 1.00 43.86 C ATOM 7963 CB GLN A 1113 12.104 43.031 −49.007 1.00 44.44 C ATOM 7964 C GLN A 1113 11.427 41.246 −47.381 1.00 45.26 C ATOM 7965 O GLN A 1113 10.228 41.152 −47.631 1.00 47.72 O ATOM 7966 N TYR A 1114 11.952 40.995 −46.185 1.00 47.45 N ATOM 7967 CA TYR A 1114 11.151 40.715 −44.990 1.00 49.79 C ATOM 7968 CB TYR A 1114 11.989 39.887 −44.016 1.00 48.00 C ATOM 7969 CG TYR A 1114 11.224 39.175 −42.934 1.00 46.89 C ATOM 7970 CD1 TYR A 1114 9.951 38.679 −43.166 1.00 48.38 C ATOM 7971 CE1 TYR A 1114 9.248 38.015 −42.173 1.00 49.62 C ATOM 7972 CZ TYR A 1114 9.830 37.820 −40.932 1.00 50.14 C ATOM 7973 OH TYR A 1114 9.127 37.149 −39.949 1.00 49.58 O ATOM 7974 CE2 TYR A 1114 11.108 38.295 −40.681 1.00 49.30 C ATOM 7975 CD2 TYR A 1114 11.795 38.964 −41.682 1.00 47.69 C ATOM 7976 C TYR A 1114 10.759 42.054 −44.363 1.00 52.62 C ATOM 7977 O TYR A 1114 11.312 43.087 −44.745 1.00 54.36 O ATOM 7978 N ASP A 1115 9.827 42.057 −43.408 1.00 55.08 N ATOM 7979 CA ASP A 1115 9.374 43.339 −42.840 1.00 60.05 C ATOM 7980 CB ASP A 1115 8.011 43.755 −43.405 1.00 61.79 C ATOM 7981 CG ASP A 1115 8.127 44.878 −44.425 1.00 61.82 C ATOM 7982 OD1 ASP A 1115 9.021 44.809 −45.298 1.00 61.29 O ATOM 7983 OD2 ASP A 1115 7.333 45.839 −44.347 1.00 62.41 O ATOM 7984 C ASP A 1115 9.452 43.579 −41.320 1.00 61.89 C ATOM 7985 O ASP A 1115 8.662 43.037 −40.539 1.00 61.75 O ATOM 7986 N ASP A 1116 10.415 44.425 −40.940 1.00 64.53 N ATOM 7987 CA ASP A 1116 10.607 44.908 −39.565 1.00 64.30 C ATOM 7988 CB ASP A 1116 11.718 44.110 −38.851 1.00 66.15 C ATOM 7989 CG ASP A 1116 11.177 43.122 −37.805 1.00 66.69 C ATOM 7990 OD1 ASP A 1116 10.062 42.569 −37.979 1.00 67.25 O ATOM 7991 OD2 ASP A 1116 11.892 42.892 −36.804 1.00 64.93 O ATOM 7992 C ASP A 1116 10.947 46.414 −39.563 1.00 61.66 C ATOM 7993 O ASP A 1116 12.063 46.814 −39.926 1.00 57.08 O ATOM 7994 N GLY A 1117 9.977 47.238 −39.165 1.00 58.28 N ATOM 7995 CA GLY A 1117 10.180 48.679 −39.069 1.00 54.36 C ATOM 7996 C GLY A 1117 10.401 49.316 −40.424 1.00 51.59 C ATOM 7997 O GLY A 1117 9.603 49.129 −41.339 1.00 49.18 O ATOM 7998 N ASP A 1121 13.226 47.049 −43.825 1.00 35.24 N ATOM 7999 CA ASP A 1121 13.222 45.764 −44.518 1.00 37.39 C ATOM 8000 CB ASP A 1121 12.649 45.929 −45.930 1.00 36.73 C ATOM 8001 C ASP A 1121 14.626 45.131 −44.584 1.00 38.64 C ATOM 8002 O ASP A 1121 15.639 45.853 −44.598 1.00 38.44 O ATOM 8003 N LEU A 1122 14.683 43.791 −44.621 1.00 36.90 N ATOM 8004 CA LEU A 1122 15.961 43.059 −44.809 1.00 34.92 C ATOM 8005 CB LEU A 1122 16.611 42.674 −43.453 1.00 35.42 C ATOM 8006 CG LEU A 1122 15.861 41.845 −42.384 1.00 36.68 C ATOM 8007 CD1 LEU A 1122 16.166 40.348 −42.483 1.00 34.54 C ATOM 8008 CD2 LEU A 1122 16.157 42.358 −40.973 1.00 36.18 C ATOM 8009 C LEU A 1122 15.850 41.833 −45.740 1.00 33.36 C ATOM 8010 O LEU A 1122 14.786 41.215 −45.850 1.00 32.98 O ATOM 8011 N ILE A 1123 16.952 41.504 −46.414 1.00 31.32 N ATOM 8012 CA ILE A 1123 17.055 40.272 −47.185 1.00 30.27 C ATOM 8013 CB ILE A 1123 18.469 40.074 −47.769 1.00 28.91 C ATOM 8014 C ILE A 1123 16.701 39.102 −46.267 1.00 30.80 C ATOM 8015 O ILE A 1123 17.352 38.890 −45.239 1.00 31.07 O ATOM 8016 N LYS A 1124 15.652 38.367 −46.631 1.00 29.94 N ATOM 8017 CA LYS A 1124 15.095 37.325 −45.779 1.00 29.34 C ATOM 8018 CB LYS A 1124 13.719 36.917 −46.289 1.00 28.86 C ATOM 8019 C LYS A 1124 15.974 36.083 −45.646 1.00 29.80 C ATOM 8020 O LYS A 1124 16.542 35.604 −46.625 1.00 29.08 O ATOM 8021 N VAL A 1125 16.057 35.567 −44.419 1.00 31.05 N ATOM 8022 CA VAL A 1125 16.703 34.283 −44.123 1.00 31.13 C ATOM 8023 CB VAL A 1125 17.363 34.280 −42.731 1.00 31.02 C ATOM 8024 CG1 VAL A 1125 18.504 33.270 −42.694 1.00 32.28 C ATOM 8025 CG2 VAL A 1125 17.857 35.669 −42.355 1.00 31.26 C ATOM 8026 C VAL A 1125 15.703 33.125 −44.132 1.00 31.51 C ATOM 8027 O VAL A 1125 14.536 33.285 −43.762 1.00 31.00 O ATOM 8028 N VAL A 1126 16.183 31.954 −44.535 1.00 32.43 N ATOM 8029 CA VAL A 1126 15.442 30.699 −44.410 1.00 32.71 C ATOM 8030 CB VAL A 1126 16.373 29.497 −44.553 1.00 34.38 C ATOM 8031 CG1 VAL A 1126 16.560 29.158 −46.015 1.00 35.81 C ATOM 8032 CG2 VAL A 1126 17.712 29.762 −43.862 1.00 35.74 C ATOM 8033 C VAL A 1126 14.720 30.513 −43.087 1.00 33.45 C ATOM 8034 O VAL A 1126 13.639 29.929 −43.059 1.00 33.37 O ATOM 8035 N ASP A 1127 15.330 30.983 −41.993 1.00 34.65 N ATOM 8036 CA ASP A 1127 14.759 30.815 −40.650 1.00 34.53 C ATOM 8037 CB ASP A 1127 15.837 30.956 −39.572 1.00 35.66 C ATOM 8038 CG ASP A 1127 16.758 29.733 −39.490 1.00 37.34 C ATOM 8039 OD1 ASP A 1127 16.329 28.606 −39.840 1.00 38.78 O ATOM 8040 OD2 ASP A 1127 17.917 29.898 −39.057 1.00 37.96 O ATOM 8041 C ASP A 1127 13.606 31.776 −40.398 1.00 33.55 C ATOM 8042 O ASP A 1127 12.640 31.421 −39.725 1.00 33.15 O ATOM 8043 N ASP A 1128 13.712 32.985 −40.952 1.00 33.41 N ATOM 8044 CA ASP A 1128 12.623 33.965 −40.929 1.00 33.99 C ATOM 8045 CB ASP A 1128 13.025 35.280 −41.621 1.00 36.13 C ATOM 8046 CG ASP A 1128 14.397 35.794 −41.189 1.00 38.22 C ATOM 8047 OD1 ASP A 1128 15.065 35.148 −40.347 1.00 39.05 O ATOM 8048 OD2 ASP A 1128 14.814 36.852 −41.711 1.00 38.99 O ATOM 8049 C ASP A 1128 11.420 33.391 −41.654 1.00 33.18 C ATOM 8050 O ASP A 1128 10.282 33.595 −41.245 1.00 33.63 O ATOM 8051 N LEU A 1129 11.677 32.684 −42.749 1.00 31.19 N ATOM 8052 CA LEU A 1129 10.604 32.044 −43.485 1.00 29.48 C ATOM 8053 CB LEU A 1129 11.006 31.750 −44.935 1.00 28.06 C ATOM 8054 CG LEU A 1129 10.536 32.776 −45.969 1.00 28.24 C ATOM 8055 CD1 LEU A 1129 9.044 33.052 −45.842 1.00 28.22 C ATOM 8056 CD2 LEU A 1129 11.314 34.075 −45.849 1.00 28.37 C ATOM 8057 C LEU A 1129 10.082 30.796 −42.793 1.00 29.30 C ATOM 8058 O LEU A 1129 8.871 30.623 −42.700 1.00 30.12 O ATOM 8059 N ILE A 1130 10.979 29.937 −42.301 1.00 28.24 N ATOM 8060 CA ILE A 1130 10.555 28.702 −41.630 1.00 28.27 C ATOM 8061 CB ILE A 1130 11.739 27.842 −41.130 1.00 27.18 C ATOM 8062 CG1 ILE A 1130 12.495 27.233 −42.318 1.00 27.17 C ATOM 8063 CD1 ILE A 1130 13.891 26.728 −41.995 1.00 26.98 C ATOM 8064 CG2 ILE A 1130 11.248 26.730 −40.208 1.00 25.72 C ATOM 8065 C ILE A 1130 9.600 29.021 −40.480 1.00 29.73 C ATOM 8066 O ILE A 1130 8.621 28.302 −40.265 1.00 30.47 O ATOM 8067 N LYS A 1131 9.862 30.114 −39.764 1.00 30.44 N ATOM 8068 CA LYS A 1131 8.957 30.525 −38.699 1.00 30.89 C ATOM 8069 CB LYS A 1131 9.648 31.414 −37.640 1.00 33.65 C ATOM 8070 CG LYS A 1131 9.946 32.849 −38.056 1.00 36.37 C ATOM 8071 CD LYS A 1131 9.416 33.857 −37.036 1.00 38.25 C ATOM 8072 CE LYS A 1131 10.467 34.898 −36.645 1.00 40.47 C ATOM 8073 NZ LYS A 1131 11.155 35.550 −37.803 1.00 41.69 N ATOM 8074 C LYS A 1131 7.668 31.150 −39.246 1.00 28.92 C ATOM 8075 O LYS A 1131 6.591 30.902 −38.711 1.00 29.52 O ATOM 8076 N VAL A 1132 7.774 31.927 −40.319 1.00 26.67 N ATOM 8077 CA VAL A 1132 6.595 32.527 −40.934 1.00 25.75 C ATOM 8078 CB VAL A 1132 6.969 33.479 −42.076 1.00 24.80 C ATOM 8079 CG1 VAL A 1132 5.770 33.756 −42.971 1.00 23.95 C ATOM 8080 CG2 VAL A 1132 7.508 34.773 −41.510 1.00 25.50 C ATOM 8081 C VAL A 1132 5.608 31.469 −41.432 1.00 26.28 C ATOM 8082 O VAL A 1132 4.423 31.535 −41.118 1.00 27.07 O ATOM 8083 N VAL A 1133 6.102 30.493 −42.189 1.00 26.12 N ATOM 8084 CA VAL A 1133 5.260 29.442 −42.761 1.00 26.19 C ATOM 8085 CB VAL A 1133 6.042 28.588 −43.783 1.00 25.61 C ATOM 8086 CG1 VAL A 1133 5.165 27.502 −44.381 1.00 24.34 C ATOM 8087 CG2 VAL A 1133 6.593 29.469 −44.891 1.00 25.52 C ATOM 8088 C VAL A 1133 4.659 28.549 −41.677 1.00 27.44 C ATOM 8089 O VAL A 1133 3.546 28.050 −41.828 1.00 27.63 O ATOM 8090 N GLU A 1134 5.387 28.363 −40.578 1.00 28.67 N ATOM 8091 CA GLU A 1134 4.909 27.505 −39.496 1.00 29.89 C ATOM 8092 CB GLU A 1134 6.054 27.057 −38.590 1.00 30.16 C ATOM 8093 CG GLU A 1134 6.801 25.848 −39.130 1.00 31.12 C ATOM 8094 CD GLU A 1134 8.034 25.486 −38.314 1.00 32.63 C ATOM 8095 OE1 GLU A 1134 8.208 26.049 −37.207 1.00 33.70 O ATOM 8096 OE2 GLU A 1134 8.831 24.629 −38.777 1.00 32.49 O ATOM 8097 C GLU A 1134 3.780 28.137 −38.693 1.00 30.17 C ATOM 8098 O GLU A 1134 2.848 27.443 −38.296 1.00 30.84 O ATOM 8099 N GLU A 1135 3.866 29.448 −38.459 1.00 30.85 N ATOM 8100 CA GLU A 1135 2.744 30.210 −37.890 1.00 31.71 C ATOM 8101 CB GLU A 1135 3.038 31.720 −37.860 1.00 35.83 C ATOM 8102 CG GLU A 1135 3.960 32.216 −36.749 1.00 40.31 C ATOM 8103 CD GLU A 1135 3.983 33.746 −36.654 1.00 43.59 C ATOM 8104 OE1 GLU A 1135 5.081 34.349 −36.792 1.00 44.96 O ATOM 8105 OE2 GLU A 1135 2.897 34.349 −36.448 1.00 43.50 O ATOM 8106 C GLU A 1135 1.535 29.991 −38.775 1.00 29.30 C ATOM 8107 O GLU A 1135 0.402 29.949 −38.302 1.00 29.05 O ATOM 8108 N LEU A 1136 1.798 29.873 −40.072 1.00 27.09 N ATOM 8109 CA LEU A 1136 0.755 29.781 −41.064 1.00 25.16 C ATOM 8110 CB LEU A 1136 1.296 30.108 −42.459 1.00 23.82 C ATOM 8111 CG LEU A 1136 1.486 31.574 −42.855 1.00 22.95 C ATOM 8112 CD1 LEU A 1136 2.167 31.681 −44.202 1.00 23.04 C ATOM 8113 CD2 LEU A 1136 0.163 32.302 −42.919 1.00 23.27 C ATOM 8114 C LEU A 1136 0.116 28.411 −41.036 1.00 24.58 C ATOM 8115 O LEU A 1136 −1.077 28.291 −41.229 1.00 24.72 O ATOM 8116 N THR A 1137 0.899 27.376 −40.775 1.00 24.38 N ATOM 8117 CA THR A 1137 0.337 26.031 −40.736 1.00 24.79 C ATOM 8118 CB THR A 1137 1.422 24.915 −40.701 1.00 25.24 C ATOM 8119 OG1 THR A 1137 2.255 25.059 −39.535 1.00 25.74 O ATOM 8120 CG2 THR A 1137 2.281 24.936 −41.964 1.00 23.91 C ATOM 8121 C THR A 1137 −0.598 25.886 −39.540 1.00 24.49 C ATOM 8122 O THR A 1137 −1.504 25.050 −39.548 1.00 24.70 O ATOM 8123 N ARG A 1138 −0.383 26.723 −38.528 1.00 24.29 N ATOM 8124 CA ARG A 1138 −1.089 26.611 −37.249 1.00 24.50 C ATOM 8125 CB ARG A 1138 −0.285 27.287 −36.131 1.00 25.68 C ATOM 8126 CG ARG A 1138 0.926 26.504 −35.666 1.00 26.62 C ATOM 8127 CD ARG A 1138 1.556 27.144 −34.436 1.00 28.39 C ATOM 8128 NE ARG A 1138 3.017 27.016 −34.489 1.00 30.69 N ATOM 8129 CZ ARG A 1138 3.876 28.036 −34.564 1.00 31.14 C ATOM 8130 NH1 ARG A 1138 3.451 29.305 −34.557 1.00 30.58 N ATOM 8131 NH2 ARG A 1138 5.177 27.780 −34.634 1.00 31.67 N ATOM 8132 C ARG A 1138 −2.506 27.180 −37.269 1.00 23.56 C ATOM 8133 O ARG A 1138 −3.223 27.076 −36.284 1.00 22.92 O ATOM 8134 N ILE A 1139 −2.898 27.785 −38.385 1.00 23.69 N ATOM 8135 CA ILE A 1139 −4.239 28.369 −38.519 1.00 23.36 C ATOM 8136 CB ILE A 1139 −4.254 29.666 −39.385 1.00 23.04 C ATOM 8137 CG1 ILE A 1139 −4.110 29.342 −40.879 1.00 22.37 C ATOM 8138 CD1 ILE A 1139 −4.149 30.562 −41.761 1.00 22.81 C ATOM 8139 CG2 ILE A 1139 −3.215 30.666 −38.893 1.00 22.81 C ATOM 8140 C ILE A 1139 −5.279 27.384 −39.064 1.00 23.61 C ATOM 8141 O ILE A 1139 −6.461 27.737 −39.166 1.00 24.82 O ATOM 8142 N HIS A 1140 −4.848 26.177 −39.439 1.00 22.36 N ATOM 8143 CA HIS A 1140 −5.789 25.133 −39.834 1.00 22.01 C ATOM 8144 CB HIS A 1140 −5.977 25.086 −41.342 1.00 22.33 C ATOM 8145 CG HIS A 1140 −4.733 24.702 −42.103 1.00 22.62 C ATOM 8146 ND1 HIS A 1140 −3.874 25.617 −42.595 1.00 21.92 N ATOM 8147 CE1 HIS A 1140 −2.868 24.986 −43.217 1.00 21.24 C ATOM 8148 NE2 HIS A 1140 −3.083 23.662 −43.133 1.00 21.58 N ATOM 8149 CD2 HIS A 1140 −4.222 23.450 −42.457 1.00 21.97 C ATOM 8150 C HIS A 1140 −5.358 23.812 −39.335 1.00 21.94 C ATOM 8151 O HIS A 1140 −4.251 23.681 −38.841 1.00 22.02 O ATOM 8152 N TRP A 1141 −6.237 22.818 −39.460 1.00 22.67 N ATOM 8153 CA TRP A 1141 −5.944 21.454 −39.024 1.00 23.30 C ATOM 8154 CB TRP A 1141 −7.163 20.547 −39.178 1.00 22.86 C ATOM 8155 CG TRP A 1141 −8.425 21.008 −38.485 1.00 22.47 C ATOM 8156 CD1 TRP A 1141 −8.545 21.577 −37.220 1.00 22.94 C ATOM 8157 NE1 TRP A 1141 −9.865 21.842 −36.920 1.00 23.01 N ATOM 8158 CE2 TRP A 1141 −10.665 21.457 −37.931 1.00 22.54 C ATOM 8159 CD2 TRP A 1141 −9.799 20.906 −38.985 1.00 22.22 C ATOM 8160 CE3 TRP A 1141 −10.378 20.440 −40.156 1.00 20.03 C ATOM 8161 CZ3 TRP A 1141 −11.771 20.520 −40.520 1.00 22.14 C ATOM 8162 CH2 TRP A 1141 −12.578 21.060 −39.274 1.00 22.30 C ATOM 8163 CZ2 TRP A 1141 −12.038 21.529 −38.071 1.00 22.30 C ATOM 8164 C TRP A 1141 −4.838 20.914 −39.863 1.00 24.67 C ATOM 8165 O TRP A 1141 −4.781 21.186 −41.076 1.00 24.33 O ATOM 8166 N SER A 1142 −3.944 20.149 −39.239 1.00 25.79 N ATOM 8167 CA SER A 1142 −2.829 19.541 −39.965 1.00 27.12 C ATOM 8168 CB SER A 1142 −1.668 19.254 −39.025 1.00 28.15 C ATOM 8169 OG SER A 1142 −2.147 19.068 −37.709 1.00 30.18 O ATOM 8170 C SER A 1142 −3.275 18.279 −40.708 1.00 27.63 C ATOM 8171 O SER A 1142 −4.279 17.657 −40.349 1.00 28.45 O ATOM 8172 N HIS A 1143 −2.541 17.921 −41.757 1.00 26.92 N ATOM 8173 CA HIS A 1143 −2.928 16.810 −42.617 1.00 25.89 C ATOM 8174 CB HIS A 1143 −2.536 17.108 −44.063 1.00 26.01 C ATOM 8175 CG HIS A 1143 −3.166 18.366 −44.608 1.00 27.02 C ATOM 8176 ND1 HIS A 1143 −4.501 18.488 −44.802 1.00 27.30 N ATOM 8177 CE1 HIS A 1143 −4.777 19.723 −45.283 1.00 27.26 C ATOM 8178 NE2 HIS A 1143 −3.613 20.397 −45.393 1.00 28.18 N ATOM 8179 CD2 HIS A 1143 −2.600 19.592 −44.982 1.00 28.02 C ATOM 8180 C HIS A 1143 −2.349 15.505 −42.147 1.00 25.45 C ATOM 8181 O HIS A 1143 −1.208 15.459 −41.692 1.00 26.78 O ATOM 8182 N PRO A 1144 −3.128 14.417 −42.242 1.00 25.11 N ATOM 8183 CA PRO A 1144 −2.606 13.109 −41.837 1.00 24.85 C ATOM 8184 CB PRO A 1144 −3.808 12.162 −42.015 1.00 25.46 C ATOM 8185 CG PRO A 1144 −4.975 13.001 −42.430 1.00 25.28 C ATOM 8186 CD PRO A 1144 −4.448 14.324 −42.889 1.00 25.38 C ATOM 8187 C PRO A 1144 −1.513 12.663 −42.773 1.00 24.34 C ATOM 8188 O PRO A 1144 −1.622 12.869 −43.975 1.00 24.88 O ATOM 8189 N GLN A 1145 −0.472 12.050 −42.235 1.00 24.27 N ATOM 8190 CA GLN A 1145 0.518 11.377 −43.068 1.00 24.84 C ATOM 8191 CB GLN A 1145 1.717 10.964 −42.220 1.00 26.10 C ATOM 8192 CG GLN A 1145 2.992 10.756 −43.008 1.00 28.40 C ATOM 8193 CD GLN A 1145 3.901 9.743 −42.351 1.00 30.36 C ATOM 8194 OE1 GLN A 1145 3.866 8.550 −42.675 1.00 31.06 O ATOM 8195 NE2 GLN A 1145 4.710 10.206 −41.405 1.00 31.51 N ATOM 8196 C GLN A 1145 −0.108 10.146 −43.746 1.00 24.10 C ATOM 8197 O GLN A 1145 −0.851 9.399 −43.128 1.00 24.36 O ATOM 8198 N PHE A 1146 0.175 9.942 −45.022 1.00 23.96 N ATOM 8199 CA PHE A 1146 −0.385 8.782 −45.725 1.00 23.80 C ATOM 8200 CB PHE A 1146 −0.501 9.056 −47.227 1.00 22.20 C ATOM 8201 CG PHE A 1146 −1.195 7.972 −47.987 1.00 20.64 C ATOM 8202 CD1 PHE A 1146 −2.569 7.812 −47.892 1.00 19.55 C ATOM 8203 CE1 PHE A 1146 −3.212 6.810 −48.593 1.00 19.02 C ATOM 8204 CZ PHE A 1146 −2.481 5.945 −49.399 1.00 19.23 C ATOM 8205 CE2 PHE A 1146 −1.104 6.097 −49.514 1.00 19.47 C ATOM 8206 CD2 PHE A 1146 −0.467 7.105 −48.806 1.00 20.29 C ATOM 8207 C PHE A 1146 0.433 7.519 −45.462 1.00 24.43 C ATOM 8208 O PHE A 1146 −0.128 6.472 −45.185 1.00 24.15 O ATOM 8209 N GLU A 1147 1.757 7.648 −45.574 1.00 26.02 N ATOM 8210 CA GLU A 1147 2.768 6.618 −45.237 1.00 26.41 C ATOM 8211 CB GLU A 1147 2.248 5.186 −45.385 1.00 25.97 C ATOM 8212 C GLU A 1147 3.970 6.831 −46.155 1.00 27.03 C ATOM 8213 O GLU A 1147 4.076 7.873 −46.823 1.00 27.12 O ATOM 8214 N ASN C 48 −55.408 33.311 −97.767 1.00 40.91 N ATOM 8215 CA ASN C 48 −54.139 33.875 −97.222 1.00 42.84 C ATOM 8216 CB ASN C 48 −53.429 32.877 −96.284 1.00 39.39 C ATOM 8217 CG ASN C 48 −53.839 33.042 −94.823 1.00 38.00 C ATOM 8218 OD1 ASN C 48 −53.083 33.568 −94.007 1.00 35.62 O ATOM 8219 ND2 ASN C 48 −55.040 32.591 −94.492 1.00 38.12 N ATOM 8220 C ASN C 48 −53.188 34.389 −98.308 1.00 46.84 C ATOM 8221 O ASN C 48 −53.537 34.420 −99.498 1.00 47.20 O ATOM 8222 N PHE C 49 −51.996 34.806 −97.874 1.00 50.66 N ATOM 8223 CA PHE C 49 −51.008 35.475 −98.724 1.00 50.09 C ATOM 8224 CB PHE C 49 −51.167 37.016 −98.609 1.00 49.42 C ATOM 8225 CG PHE C 49 −50.104 37.713 −97.779 1.00 48.77 C ATOM 8226 CD1 PHE C 49 −49.775 37.281 −96.500 1.00 47.83 C ATOM 8227 CE1 PHE C 49 −48.795 37.935 −95.760 1.00 47.57 C ATOM 8228 CZ PHE C 49 −48.158 39.055 −96.273 1.00 47.51 C ATOM 8229 CE2 PHE C 49 −48.491 39.516 −97.536 1.00 47.94 C ATOM 8230 CD2 PHE C 49 −49.460 38.850 −98.279 1.00 49.84 C ATOM 8231 C PHE C 49 −49.593 34.970 −98.382 1.00 51.55 C ATOM 8232 O PHE C 49 −49.401 34.261 −97.377 1.00 51.51 O ATOM 8233 N ASP C 50 −48.616 35.317 −99.220 1.00 51.27 N ATOM 8234 CA ASP C 50 −47.261 34.758 −99.115 1.00 50.17 C ATOM 8235 CB ASP C 50 −46.541 34.879 −100.465 1.00 50.24 C ATOM 8236 CG ASP C 50 −45.435 33.861 −100.633 1.00 51.15 C ATOM 8237 OD1 ASP C 50 −45.740 32.652 −100.734 1.00 52.59 O ATOM 8238 OD2 ASP C 50 −44.259 34.271 −100.685 1.00 51.52 O ATOM 8239 C ASP C 50 −46.443 35.415 −97.995 1.00 48.23 C ATOM 8240 O ASP C 50 −45.980 36.549 −98.139 1.00 49.81 O ATOM 8241 N THR C 51 −46.255 34.693 −96.890 1.00 45.50 N ATOM 8242 CA THR C 51 −45.641 35.267 −95.675 1.00 44.95 C ATOM 8243 CB THR C 51 −45.946 34.419 −94.415 1.00 43.31 C ATOM 8244 OG1 THR C 51 −45.321 33.135 −94.525 1.00 44.12 O ATOM 8245 CG2 THR C 51 −47.444 34.248 −94.235 1.00 41.89 C ATOM 8246 C THR C 51 −44.126 35.566 −95.758 1.00 44.81 C ATOM 8247 O THR C 51 −43.565 36.219 −94.867 1.00 43.82 O ATOM 8248 N SER C 52 −43.478 35.104 −96.828 1.00 45.02 N ATOM 8249 CA SER C 52 −42.055 35.379 −97.052 1.00 44.99 C ATOM 8250 CB SER C 52 −41.395 34.222 −97.800 1.00 43.01 C ATOM 8251 OG SER C 52 −41.596 34.354 −99.194 1.00 41.72 O ATOM 8252 C SER C 52 −41.824 36.698 −97.814 1.00 45.94 C ATOM 8253 O SER C 52 −40.684 37.178 −97.922 1.00 47.52 O ATOM 8254 N LEU C 53 −42.909 37.273 −98.333 1.00 43.31 N ATOM 8255 CA LEU C 53 −42.842 38.513 −99.098 1.00 41.76 C ATOM 8256 CB LEU C 53 −44.171 38.779 −99.829 1.00 42.36 C ATOM 8257 C LEU C 53 −42.387 39.749 −98.293 1.00 40.35 C ATOM 8258 O LEU C 53 −41.580 40.527 −98.795 1.00 41.07 O ATOM 8259 N PRO C 54 −42.900 39.942 −97.053 1.00 39.36 N ATOM 8260 CA PRO C 54 −42.531 41.171 −96.346 1.00 38.48 C ATOM 8261 CB PRO C 54 −43.415 41.147 −95.094 1.00 38.37 C ATOM 8262 CG PRO C 54 −44.535 40.228 −95.423 1.00 39.84 C ATOM 8263 CD PRO C 54 −43.922 39.184 −96.307 1.00 40.87 C ATOM 8264 C PRO C 54 −41.067 41.231 −95.943 1.00 39.10 C ATOM 8265 O PRO C 54 −40.507 42.315 −95.861 1.00 41.57 O ATOM 8266 N THR C 55 −40.445 40.080 −95.706 1.00 40.09 N ATOM 8267 CA THR C 55 −39.035 40.046 −95.271 1.00 39.55 C ATOM 8268 CB THR C 55 −38.713 38.777 −94.418 1.00 40.00 C ATOM 8269 OG1 THR C 55 −37.426 38.916 93.790 1.00 37.92 O ATOM 8270 CG2 THR C 55 −38.760 37.494 −95.267 1.00 38.32 C ATOM 8271 C THR C 55 −38.025 40.225 −96.425 1.00 37.57 C ATOM 8272 O THR C 55 −36.846 40.526 −96.186 1.00 38.59 O ATOM 8273 N SER C 56 −38.497 40.044 −97.661 1.00 35.25 N ATOM 8274 CA SER C 56 −37.677 40.264 −98.861 1.00 33.65 C ATOM 8275 CB SER C 56 −38.051 39.269 −99.962 1.00 33.12 C ATOM 8276 OG SER C 56 −39.389 39.468 −100.367 1.00 32.78 O ATOM 8277 C SER C 56 −37.742 41.709 −99.400 1.00 31.71 C ATOM 8278 O SER C 56 −37.073 42.033 −100.376 1.00 32.12 O ATOM 8279 N HIS C 57 −38.558 42.554 −98.766 1.00 30.10 N ATOM 8280 CA HIS C 57 −38.565 44.009 −99.002 1.00 28.86 C ATOM 8281 CB HIS C 57 −37.305 44.653 −98.426 1.00 28.33 C ATOM 8282 CG HIS C 57 −37.177 44.504 −96.931 1.00 27.92 C ATOM 8283 ND1 HIS C 57 −37.923 45.208 −96.072 1.00 27.40 N ATOM 8284 CE1 HIS C 57 −37.600 44.866 −94.816 1.00 27.91 C ATOM 8285 NE2 HIS C 57 −36.635 43.942 −94.871 1.00 28.17 N ATOM 8286 CD2 HIS C 57 −36.347 43.697 −96.159 1.00 28.18 C ATOM 8287 C HIS C 57 −38.734 44.395 −100.442 1.00 27.94 C ATOM 8288 O HIS C 57 −38.009 45.246 −100.961 1.00 27.51 O ATOM 8289 N THR C 58 −39.713 43.780 −101.090 1.00 27.09 N ATOM 8290 CA THR C 58 −39.888 43.908 −102.525 1.00 27.76 C ATOM 8291 CB THR C 58 −41.006 42.972 −103.032 1.00 28.09 C ATOM 8292 OG1 THR C 58 −42.215 43.254 −102.326 1.00 29.15 O ATOM 8293 CG2 THR C 58 −40.641 41.504 −102.808 1.00 27.65 C ATOM 8294 C THR C 58 −40.170 45.360 −102.949 1.00 28.51 C ATOM 8295 O THR C 58 −39.881 45.748 −104.094 1.00 28.40 O ATOM 8296 N TYR C 59 −40.711 46.150 −102.015 1.00 27.85 N ATOM 8297 CA TYR C 59 −41.034 47.566 −102.230 1.00 27.90 C ATOM 8298 CB TYR C 59 −41.785 48.103 −101.019 1.00 27.30 C ATOM 8299 CG TYR C 59 −40.934 48.130 −99.765 1.00 27.52 C ATOM 8300 CD1 TYR C 59 −40.152 49.245 −99.440 1.00 26.39 C ATOM 8301 CE1 TYR C 59 −39.360 49.250 −98.302 1.00 27.25 C ATOM 8302 CZ TYR C 59 −39.347 48.130 −97.461 1.00 28.31 C ATOM 8303 OH TYR C 59 −38.584 48.096 −96.307 1.00 28.36 O ATOM 8304 CE2 TYR C 59 −40.111 47.021 −97.770 1.00 28.27 C ATOM 8305 CD2 TYR C 59 −40.894 47.025 −98.913 1.00 28.11 C ATOM 8306 C TYR C 59 −39.804 48.456 −102.474 1.00 29.86 C ATOM 8307 O TYR C 59 −39.946 49.667 −102.687 1.00 30.37 O ATOM 8308 N LEU C 60 −38.607 47.865 −102.401 1.00 32.45 N ATOM 8309 CA LEU C 60 −37.341 48.583 −102.594 1.00 34.04 C ATOM 8310 CB LEU C 60 −36.234 47.974 −101.730 1.00 32.88 C ATOM 8311 CG LEU C 60 −36.009 48.441 −100.289 1.00 32.37 C ATOM 8312 CD1 LEU C 60 −35.394 47.319 −99.472 1.00 32.04 C ATOM 8313 CD2 LEU C 60 −35.104 49.658 −100.242 1.00 32.19 C ATOM 8314 C LEU C 60 −36.912 48.565 −104.061 1.00 38.02 C ATOM 8315 O LEU C 60 −36.187 49.460 −104.512 1.00 40.11 O ATOM 8316 N GLY C 61 −37.343 47.539 −104.797 1.00 39.84 N ATOM 8317 CA GLY C 61 −37.122 47.483 −106.238 1.00 42.08 C ATOM 8318 C GLY C 61 −36.459 46.218 −106.742 1.00 46.03 C ATOM 8319 O GLY C 61 −36.185 45.295 −105.972 1.00 45.00 O ATOM 8320 N ALA C 62 −36.191 46.210 −108.049 1.00 50.43 N ATOM 8321 CA ALA C 62 −35.628 45.071 −108.792 1.00 53.17 C ATOM 8322 CB ALA C 62 −34.852 45.562 −110.019 1.00 52.14 C ATOM 8323 C ALA C 62 −34.799 44.064 −107.974 1.00 54.39 C ATOM 8324 O ALA C 62 −35.366 43.211 −107.286 1.00 54.82 O ATOM 8325 N ASP C 63 −33.471 44.147 −108.069 1.00 56.92 N ATOM 8326 CA ASP C 63 −32.586 43.127 −107.477 1.00 59.41 C ATOM 8327 CB ASP C 63 −32.403 41.939 −108.435 1.00 58.55 C ATOM 8328 C ASP C 63 −31.225 43.685 −107.062 1.00 58.37 C ATOM 8329 O ASP C 63 −30.595 44.446 −107.812 1.00 57.32 O ATOM 8330 N MET C 64 −30.774 43.278 −105.875 1.00 55.30 N ATOM 8331 CA MET C 64 −29.567 43.832 −105.259 1.00 54.32 C ATOM 8332 CB MET C 64 −29.862 44.262 −103.814 1.00 52.60 C ATOM 8333 CG MET C 64 −31.114 45.125 −103.671 1.00 52.32 C ATOM 8334 SD MET C 64 −31.292 45.970 −102.081 1.00 50.83 S ATOM 8335 CE MET C 64 −32.872 46.771 −102.320 1.00 49.66 C ATOM 8336 C MET C 64 −28.387 42.857 −105.298 1.00 54.43 C ATOM 8337 O MET C 64 −28.561 41.665 −105.046 1.00 55.10 O ATOM 8338 N GLU C 65 −27.196 43.368 −105.627 1.00 54.41 N ATOM 8339 CA GLU C 65 −25.953 42.582 −105.563 1.00 53.12 C ATOM 8340 CB GLU C 65 −24.752 43.427 −106.004 1.00 50.75 C ATOM 8341 C GLU C 65 −25.742 42.069 −104.139 1.00 54.15 C ATOM 8342 O GLU C 65 −25.888 42.825 −103.180 1.00 55.22 O ATOM 8343 N GLU C 66 −25.416 40.785 −103.999 1.00 55.16 N ATOM 8344 CA GLU C 66 −25.337 40.156 −102.671 1.00 52.95 C ATOM 8345 CB GLU C 66 −26.154 38.862 −102.627 1.00 52.21 C ATOM 8346 CG GLU C 66 −27.509 38.967 −103.304 1.00 53.69 C ATOM 8347 CD GLU C 66 −28.582 38.167 −102.601 1.00 55.90 C ATOM 8348 OE1 GLU C 66 −28.870 37.037 −103.053 1.00 55.95 O ATOM 8349 OE2 GLU C 66 −29.136 38.669 −101.594 1.00 57.68 O ATOM 8350 C GLU C 66 −23.901 39.890 −102.238 1.00 52.01 C ATOM 8351 O GLU C 66 −23.049 39.573 −103.063 1.00 52.32 O ATOM 8352 N PHE C 67 −23.643 40.023 −100.939 1.00 52.66 N ATOM 8353 CA PHE C 67 −22.306 39.822 −100.396 1.00 54.50 C ATOM 8354 CB PHE C 67 −21.724 41.143 −99.888 1.00 54.48 C ATOM 8355 CG PHE C 67 −21.525 42.170 −100.967 1.00 56.05 C ATOM 8356 CD1 PHE C 67 −20.561 41.984 −101.958 1.00 56.74 C ATOM 8357 CE1 PHE C 67 −20.381 42.926 −102.959 1.00 56.98 C ATOM 8358 CZ PHE C 67 −21.163 44.072 −102.977 1.00 56.67 C ATOM 8359 CE2 PHE C 67 −22.123 44.272 −101.996 1.00 55.95 C ATOM 8360 CD2 PHE C 67 −22.302 43.325 −100.998 1.00 55.94 C ATOM 8361 C PHE C 67 −22.304 38.784 −99.287 1.00 57.38 C ATOM 8362 O PHE C 67 −23.044 38.919 −98.305 1.00 58.95 O ATOM 8363 N HIS C 68 −21.476 37.748 −99.458 1.00 58.27 N ATOM 8364 CA HIS C 68 −21.325 36.679 −98.464 1.00 57.39 C ATOM 8365 CB HIS C 68 −20.694 35.444 −99.099 1.00 56.41 C ATOM 8366 C HIS C 68 −20.527 37.160 −97.273 1.00 56.98 C ATOM 8367 O HIS C 68 −19.295 37.248 −97.316 1.00 54.86 O ATOM 8368 N GLY C 69 −21.238 37.479 −96.196 1.00 57.27 N ATOM 8369 CA GLY C 69 −20.667 38.232 −95.079 1.00 55.51 C ATOM 8370 C GLY C 69 −19.787 37.461 −94.114 1.00 54.69 C ATOM 8371 O GLY C 69 −20.258 36.570 −93.392 1.00 53.58 O ATOM 8372 N ARG C 70 −18.506 37.820 −94.089 1.00 52.20 N ATOM 8373 CA ARG C 70 −17.578 37.261 −93.117 1.00 50.97 C ATOM 8374 CB ARG C 70 −16.280 36.786 −93.790 1.00 54.50 C ATOM 8375 CG ARG C 70 −16.473 35.979 −95.071 1.00 56.51 C ATOM 8376 CD ARG C 70 −15.149 35.471 −95.626 1.00 59.46 C ATOM 8377 NE ARG C 70 −14.806 34.154 −95.086 1.00 64.81 N ATOM 8378 CZ ARG C 70 −14.048 33.940 −94.005 1.00 66.91 C ATOM 8379 NH1 ARG C 70 −13.524 34.961 −93.329 1.00 68.47 N ATOM 8380 NH2 ARG C 70 −13.810 32.696 −93.596 1.00 64.63 N ATOM 8381 C ARG C 70 −17.302 38.303 −92.032 1.00 48.28 C ATOM 8382 O ARG C 70 −18.105 38.465 −91.124 1.00 48.50 O ATOM 8383 N THR C 71 −16.189 39.026 −92.165 1.00 48.43 N ATOM 8384 CA THR C 71 −15.677 39.987 −91.149 1.00 49.20 C ATOM 8385 CB THR C 71 −15.370 41.396 −91.758 1.00 47.69 C ATOM 8386 OG1 THR C 71 −15.215 42.369 −90.709 1.00 43.60 O ATOM 8387 CG2 THR C 71 −16.475 41.846 −92.732 1.00 47.02 C ATOM 8388 C THR C 71 −16.429 40.115 −89.795 1.00 49.59 C ATOM 8389 O THR C 71 −17.460 40.797 −89.695 1.00 40.33 O ATOM 8390 N LEU C 72 −15.891 39.432 −88.776 1.00 47.99 N ATOM 8391 CA LEU C 72 −16.270 39.628 −87.370 1.00 47.25 C ATOM 8392 CB LEU C 72 −16.737 38.313 −86.729 1.00 46.30 C ATOM 8393 CG LEU C 72 −18.165 37.785 −86.960 1.00 45.56 C ATOM 8394 CD1 LEU C 72 −18.357 36.441 −86.263 1.00 42.17 C ATOM 8395 CD2 LEU C 72 −19.235 38.784 −86.525 1.00 44.00 C ATOM 8396 C LEU C 72 −15.075 40.178 −86.593 1.00 47.20 C ATOM 8397 O LEU C 72 −13.928 39.924 −86.959 1.00 49.59 O ATOM 8398 N HIS C 73 −15.343 40.922 −85.523 1.00 46.24 N ATOM 8399 CA HIS C 73 −14.284 41.543 −84.720 1.00 46.89 C ATOM 8400 CB HIS C 73 −14.554 43.039 −84.548 1.00 47.59 C ATOM 8401 CG HIS C 73 −14.571 43.814 −85.849 1.00 48.07 C ATOM 8402 ND1 HIS C 73 −13.624 44.716 −86.168 1.00 48.75 N ATOM 8403 CE1 HIS C 73 −13.890 45.240 −87.382 1.00 48.07 C ATOM 8404 NE2 HIS C 73 −15.012 44.669 −87.845 1.00 48.06 N ATOM 8405 CD2 HIS C 73 −15.461 43.784 −86.924 1.00 48.45 C ATOM 8406 C HIS C 73 −14.185 40.867 −83.382 1.00 45.92 C ATOM 8407 O HIS C 73 −15.183 40.748 −82.681 1.00 44.78 O ATOM 8408 N ASP C 74 −12.984 40.415 −83.012 1.00 47.57 N ATOM 8409 CA ASP C 74 −12.818 39.600 −81.792 1.00 48.34 C ATOM 8410 CB ASP C 74 −11.510 38.766 −81.781 1.00 48.15 C ATOM 8411 CG ASP C 74 −10.245 39.605 −82.009 1.00 49.95 C ATOM 8412 OD1 ASP C 74 −10.344 40.737 −82.534 1.00 52.10 O ATOM 8413 OD2 ASP C 74 −9.139 39.111 −81.680 1.00 47.80 O ATOM 8414 C ASP C 74 −13.033 40.362 −80.488 1.00 48.96 C ATOM 8415 O ASP C 74 −12.909 41.589 −80.441 1.00 47.43 O ATOM 8416 N ASP C 75 −13.359 39.611 −79.438 1.00 51.08 N ATOM 8417 CA ASP C 75 −13.953 40.156 −78.215 1.00 52.40 C ATOM 8418 CB ASP C 75 −14.342 39.019 −77.264 1.00 52.50 C ATOM 8419 CG ASP C 75 −15.570 38.257 −77.732 1.00 52.35 C ATOM 8420 OD1 ASP C 75 −16.543 38.893 −78.204 1.00 51.16 O ATOM 8421 OD2 ASP C 75 −15.568 37.015 −77.605 1.00 54.33 O ATOM 8422 C ASP C 75 −13.130 41.204 −77.470 1.00 52.85 C ATOM 8423 O ASP C 75 −11.901 41.164 −77.472 1.00 52.46 O ATOM 8424 N ASP C 76 −13.850 42.136 −76.839 1.00 54.53 N ATOM 8425 CA ASP C 76 −13.295 43.221 −76.004 1.00 53.76 C ATOM 8426 CB ASP C 76 −12.544 42.675 −74.780 1.00 55.56 C ATOM 8427 CG ASP C 76 −13.463 41.955 −73.804 1.00 58.08 C ATOM 8428 OD2 ASP C 76 −13.803 42.545 −72.755 1.00 58.30 O ATOM 8429 OD1 ASP C 76 −13.853 40.801 −74.088 1.00 59.22 O ATOM 8430 C ASP C 76 −12.456 44.251 −76.754 1.00 51.64 C ATOM 8431 O ASP C 76 −12.004 45.226 −76.156 1.00 51.64 O ATOM 8432 N SER C 77 −12.301 44.061 −78.064 1.00 50.44 N ATOM 8433 CA SER C 77 −11.459 44.929 −78.894 1.00 50.16 C ATOM 8434 CB SER C 77 −11.391 44.389 −80.318 1.00 50.52 C ATOM 8435 OG SER C 77 −10.620 45.252 −81.134 1.00 54.29 O ATOM 8436 C SER C 77 −11.918 46.388 −78.928 1.00 49.81 C ATOM 8437 O SER C 77 −13.042 46.699 −78.532 1.00 51.81 O ATOM 8438 N CYS C 78 −11.038 47.273 −79.399 1.00 47.65 N ATOM 8439 CA CYS C 78 −11.400 48.670 −79.655 1.00 46.02 C ATOM 8440 CB CYS C 78 −10.479 49.639 −78.920 1.00 49.52 C ATOM 8441 SG CYS C 78 −10.865 49.775 −77.158 1.00 59.25 S ATOM 8442 C CYS C 78 −11.398 48.957 −81.138 1.00 42.86 C ATOM 8443 O CYS C 78 −10.356 48.906 −81.793 1.00 41.91 O ATOM 8444 N GLN C 79 −12.587 49.244 −81.658 1.00 40.17 N ATOM 8445 CA GLN C 79 −12.786 49.484 −83.076 1.00 37.66 C ATOM 8446 CB GLN C 79 −13.766 48.470 −83.663 1.00 36.38 C ATOM 8447 SG GLN C 79 −13.253 47.038 −83.667 1.00 36.49 C ATOM 8448 C GLN C 79 −11.980 46.869 −84.470 1.00 35.97 C ATOM 8449 O GLN C 79 −11.936 47.169 −85.669 1.00 35.60 O ATOM 8450 N GLN C 79 −10.937 46.382 −83.815 1.00 35.58 N ATOM 8451 C GLN C 79 −13.303 50.885 −83.319 1.00 36.80 C ATOM 8452 O GLN C 79 −14.006 51.454 −82.484 1.00 37.73 O ATOM 8453 N VAL C 80 −12.929 51.440 −84.464 1.00 35.52 N ATOM 8454 CA VAL C 80 −13.492 52.690 −84.941 1.00 33.70 C ATOM 8455 CB VAL C 80 −12.381 53.711 −85.285 1.00 32.73 C ATOM 8456 CG1 VAL C 80 −12.919 54.846 −86.150 1.00 32.80 C ATOM 8457 CG2 VAL C 80 −11.750 54.256 −84.009 1.00 31.43 C ATOM 8458 C VAL C 80 −14.380 52.365 −86.144 1.00 32.83 C ATOM 8459 O VAL C 80 −13.911 51.825 −87.150 1.00 32.58 O ATOM 8460 N ILE C 81 −15.672 52.656 −86.012 1.00 32.51 N ATOM 8461 CA ILE C 81 −16.655 52.357 −87.068 1.00 32.66 C ATOM 8462 CB ILE C 81 −17.672 51.274 −86.625 1.00 31.62 C ATOM 8463 CG1 ILE C 81 −16.989 50.179 −85.814 1.00 31.54 C ATOM 8464 CD1 ILE C 81 −17.950 49.306 −85.047 1.00 31.94 C ATOM 8465 CG2 ILE C 81 −18.355 50.659 −87.832 1.00 31.39 C ATOM 8466 C ILE C 81 −17.433 53.617 −87.474 1.00 32.78 C ATOM 8467 O ILE C 81 −17.749 54.453 −86.622 1.00 33.15 O ATOM 8468 N PRO C 82 −17.737 53.763 −88.779 1.00 32.81 N ATOM 8469 CA PRO C 82 −18.646 54.835 −89.209 1.00 32.86 C ATOM 8470 CB PRO C 82 −18.718 54.645 −90.733 1.00 32.78 C ATOM 8471 CG PRO C 82 −18.244 53.239 −90.975 1.00 32.91 C ATOM 8472 CD PRO C 82 −17.193 53.019 −89.930 1.00 32.48 C ATOM 8473 C PRO C 82 −20.043 54.687 −88.602 1.00 31.92 C ATOM 8474 O PRO C 82 −20.536 53.571 −88.459 1.00 31.91 O ATOM 8475 N VAL C 83 −20.652 55.810 −88.238 1.00 31.55 N ATOM 8476 CA VAL C 83 −22.044 55.850 −87.820 1.00 32.34 C ATOM 8477 CB VAL C 83 −22.197 56.544 −86.457 1.00 32.37 C ATOM 8478 CG1 VAL C 83 −23.666 56.755 −86.111 1.00 31.90 C ATOM 8479 CG2 VAL C 83 −21.491 55.748 −85.370 1.00 32.81 C ATOM 8480 C VAL C 83 −22.820 56.639 −88.853 1.00 34.24 C ATOM 8481 O VAL C 83 −22.450 57.773 −89.180 1.00 35.46 O ATOM 8482 N LEU C 84 −23.893 56.054 −89.374 1.00 36.25 N ATOM 8483 CA LEU C 84 −24.703 56.748 −90.375 1.00 39.49 C ATOM 8484 CB LEU C 84 −25.508 55.755 −91.216 1.00 40.36 C ATOM 8485 CG LEU C 84 −24.822 54.828 −92.223 1.00 39.79 C ATOM 8486 CD1 LEU C 84 −25.824 54.523 −93.321 1.00 39.35 C ATOM 8487 CD2 LEU C 84 −23.540 55.403 −92.817 1.00 39.54 C ATOM 8488 C LEU C 84 −25.640 57.789 −89.753 1.00 41.47 C ATOM 8489 O LEU C 84 −26.301 57.501 −88.752 1.00 41.38 O ATOM 8490 N PRO C 85 −25.703 59.001 −90.353 1.00 44.30 N ATOM 8491 CA PRO C 85 −26.596 60.098 −89.923 1.00 46.25 C ATOM 8492 CB PRO C 85 −26.252 61.241 −90.894 1.00 45.46 C ATOM 8493 CG PRO C 85 −24.933 60.887 −91.476 1.00 45.49 C ATOM 8494 CD PRO C 85 −24.898 59.389 −91.524 1.00 45.11 C ATOM 8495 C PRO C 85 −28.087 59.762 −90.062 1.00 48.12 C ATOM 8496 O PRO C 85 −28.484 59.078 −91.012 1.00 49.21 O ATOM 8497 N GLN C 86 −28.896 60.250 −89.119 1.00 48.69 N ATOM 8498 CA GLN C 86 −30.367 60.123 −89.172 1.00 49.36 C ATOM 8499 CB GLN C 86 −30.948 60.841 −90.399 1.00 51.10 C ATOM 8500 CG GLN C 86 −30.607 62.316 −90.486 1.00 53.96 C ATOM 8501 CD GLN C 86 −30.135 62.709 −91.871 1.00 57.88 C ATOM 8502 OE1 GLN C 86 −29.172 63.467 −92.015 1.00 60.52 O ATOM 8503 NE2 GLN C 86 −30.800 62.183 −92.904 1.00 56.82 N ATOM 8504 C GLN C 86 −30.878 58.682 −89.116 1.00 47.33 C ATOM 8505 O GLN C 86 −32.064 58.426 −89.326 1.00 46.93 O ATOM 8506 N VAL C 87 −29.985 57.741 −88.847 1.00 46.99 N ATOM 8507 CA VAL C 87 −30.416 56.400 −88.509 1.00 48.31 C ATOM 8508 CB VAL C 87 −29.360 55.326 −88.857 1.00 48.85 C ATOM 8509 CG1 VAL C 87 −29.812 53.952 −88.378 1.00 49.43 C ATOM 8510 CG2 VAL C 87 −29.106 55.293 −90.355 1.00 49.29 C ATOM 8511 C VAL C 87 −30.749 56.388 −87.021 1.00 48.65 C ATOM 8512 O VAL C 87 −29.887 56.634 −86.172 1.00 48.40 O ATOM 8513 N MET C 88 −32.022 56.155 −86.726 1.00 49.63 N ATOM 8514 CA MET C 88 −32.494 55.989 −85.362 1.00 50.44 C ATOM 8515 CB MET C 88 −33.556 57.042 −85.008 1.00 52.67 C ATOM 8516 CG MET C 88 −33.175 58.483 −85.321 1.00 57.19 C ATOM 8517 SD MET C 88 −31.978 59.218 −84.179 1.00 62.30 S ATOM 8518 CE MET C 88 −31.746 60.841 −84.924 1.00 60.71 C ATOM 8519 C MET C 88 −33.095 54.594 −85.245 1.00 49.60 C ATOM 8520 O MET C 88 −33.981 54.227 −86.027 1.00 50.22 O ATOM 8521 N MET C 89 −32.579 53.813 −84.298 1.00 46.72 N ATOM 8522 CA MET C 89 −33.185 52.541 −83.893 1.00 46.94 C ATOM 8523 CB MET C 89 −33.848 51.801 −85.066 1.00 48.19 C ATOM 8524 CG MET C 89 −32.898 51.017 −85.952 1.00 48.58 C ATOM 8525 SD MET C 89 −33.741 49.657 −86.774 1.00 50.63 S ATOM 8526 CE MET C 89 −34.024 48.535 −85.413 1.00 49.84 C ATOM 8527 C MET C 89 −32.186 51.631 −83.200 1.00 45.40 C ATOM 8528 O MET C 89 −31.007 51.614 −83.541 1.00 46.11 O ATOM 8529 N ILE C 90 −32.673 50.875 −82.225 1.00 43.10 N ATOM 8530 CA ILE C 90 −31.851 49.904 −81.529 1.00 41.54 C ATOM 8531 CB ILE C 90 −32.348 49.668 −80.082 1.00 41.55 C ATOM 8532 CG1 ILE C 90 −32.304 50.973 −79.279 1.00 42.36 C ATOM 8533 CD1 ILE C 90 −33.529 51.854 −79.442 1.00 43.41 C ATOM 8534 CG2 ILE C 90 −31.512 48.609 −79.382 1.00 40.51 C ATOM 8535 C ILE C 90 −31.870 48.620 −82.348 1.00 39.60 C ATOM 8536 O ILE C 90 −32.909 47.986 −82.501 1.00 41.67 O ATOM 8537 N LEU C 91 −30.717 48.260 −82.892 1.00 36.47 N ATOM 8538 CA LEU C 91 −30.624 47.153 −83.831 1.00 35.24 C ATOM 8539 CB LEU C 91 −29.780 47.591 −85.035 1.00 34.60 C ATOM 8540 CG LEU C 91 −29.450 46.756 −86.271 1.00 33.80 C ATOM 8541 CD1 LEU C 91 −28.042 46.204 −86.154 1.00 33.17 C ATOM 8542 CD2 LEU C 91 −30.475 45.671 −86.564 1.00 33.43 C ATOM 8543 C LEU C 91 −30.052 45.914 −83.132 1.00 36.11 C ATOM 8544 O LEU C 91 −29.052 45.992 −82.413 1.00 39.89 O ATOM 8545 N ILE C 92 −30.707 44.777 −83.326 1.00 33.21 N ATOM 8546 CA ILE C 92 −30.378 43.560 −82.603 1.00 30.24 C ATOM 8547 CB ILE C 92 −31.671 42.904 −82.060 1.00 30.06 C ATOM 8548 CG1 ILE C 92 −32.304 43.832 −81.022 1.00 30.22 C ATOM 8549 CD1 ILE C 92 −33.796 43.669 −80.865 1.00 30.47 C ATOM 8550 CG2 ILE C 92 −31.410 41.535 −81.432 1.00 30.01 C ATOM 8551 C ILE C 92 −29.594 42.627 −83.521 1.00 29.15 C ATOM 8552 O ILE C 92 −29.911 42.516 −84.700 1.00 27.90 O ATOM 8553 N PRO C 93 −28.538 41.979 −82.992 1.00 29.20 N ATOM 8554 CA PRO C 93 −27.841 40.941 −83.753 1.00 29.00 C ATOM 8555 CB PRO C 93 −27.068 40.183 −82.674 1.00 28.97 C ATOM 8556 CG PRO C 93 −26.763 41.222 −81.656 1.00 29.19 C ATOM 8557 CD PRO C 93 −27.891 42.225 −81.689 1.00 29.52 C ATOM 8558 C PRO C 93 −28.812 40.001 −84.465 1.00 28.65 C ATOM 8559 O PRO C 93 −29.724 39.454 −83.834 1.00 28.36 O ATOM 8560 N GLY C 94 −28.630 39.852 −85.775 1.00 28.42 N ATOM 8561 CA GLY C 94 −29.461 38.958 −86.583 1.00 28.00 C ATOM 8562 C GLY C 94 −30.690 39.613 −87.184 1.00 27.59 C ATOM 8563 O GLY C 94 −31.316 39.053 −88.072 1.00 27.01 O ATOM 8564 N GLN C 95 −31.046 40.793 −86.681 1.00 28.15 N ATOM 8565 CA GLN C 95 −32.199 41.537 −87.176 1.00 28.34 C ATOM 8566 CB GLN C 95 −32.576 42.658 −86.206 1.00 28.24 C ATOM 8567 CG GLN C 95 −33.965 43.251 −86.403 1.00 28.38 C ATOM 8568 CD GLN C 95 −34.318 44.351 −85.396 1.00 28.34 C ATOM 8569 OE1 GLN C 95 −35.468 44.790 −85.332 1.00 29.15 O ATOM 8570 NE2 GLN C 95 −33.340 44.797 −84.614 1.00 27.40 N ATOM 8571 C GLN C 95 −31.826 42.119 −88.515 1.00 29.86 C ATOM 8572 O GLN C 95 −30.661 42.414 −88.781 1.00 31.52 O ATOM 8573 N THR C 96 −32.807 42.277 −89.377 1.00 30.47 N ATOM 8574 CA THR C 96 −32.517 42.777 −90.689 1.00 30.40 C ATOM 8575 CB THR C 96 −33.226 41.908 −91.742 1.00 30.74 C ATOM 8576 OG1 THR C 96 −32.317 41.622 −92.810 1.00 32.25 O ATOM 8577 CG2 THR C 96 −34.523 42.558 −92.265 1.00 32.34 C ATOM 8578 C THR C 96 −32.851 44.282 −90.742 1.00 30.48 C ATOM 8579 O THR C 96 −33.789 44.731 −90.073 1.00 32.69 O ATOM 8580 N LEU C 97 −32.063 45.059 −91.485 1.00 28.56 N ATOM 8581 CA LEU C 97 −32.244 46.508 −91.535 1.00 27.45 C ATOM 8582 CB LEU C 97 −31.191 47.202 −90.671 1.00 27.25 C ATOM 8583 OG1 LEU C 97 −31.188 48.738 −90.646 1.00 27.16 C ATOM 8584 CD1 LEU C 97 −32.492 49.277 −90.087 1.00 27.40 C ATOM 8585 CD2 LEU C 97 −30.008 49.289 −89.860 1.00 26.55 C ATOM 8586 C LEU C 97 −32.181 47.052 −92.959 1.00 27.79 C ATOM 8587 O LEU C 97 −31.124 47.016 −93.583 1.00 28.86 O ATOM 8588 N PRO C 98 −33.310 47.571 −93.482 1.00 27.51 N ATOM 8589 CA PRO C 98 −33.285 48.137 −94.827 1.00 26.97 C ATOM 8590 CB PRO C 98 −34.661 47.770 −95.370 1.00 26.42 C ATOM 8591 CG PRO C 98 −35.545 47.702 −94.154 1.00 26.82 C ATOM 8592 CD PRO C 98 −34.675 47.572 −92.925 1.00 27.20 C ATOM 8593 C PRO C 98 −33.105 49.656 −94.781 1.00 27.08 C ATOM 8594 O PRO C 98 −33.591 50.304 −93.856 1.00 27.67 O ATOM 8595 N LEU C 99 −32.398 50.212 −95.759 1.00 26.93 N ATOM 8596 CA LEU C 99 −32.100 51.645 −95.768 1.00 26.96 C ATOM 8597 CB LEU C 99 −30.690 51.922 −95.219 1.00 26.12 C ATOM 8598 CG LEU C 99 −30.315 51.598 −93.765 1.00 25.67 C ATOM 8599 CD1 LEU C 99 −28.900 52.075 −93.471 1.00 24.67 C ATOM 8600 CD2 LEU C 99 −31.292 52.206 −92.764 1.00 25.87 C ATOM 8601 C LEU C 99 −32.247 52.264 −97.159 1.00 27.43 C ATOM 8602 O LEU C 99 −32.173 51.567 −98.170 1.00 27.81 O ATOM 8603 N GLN C 100 −32.466 53.577 −97.192 1.00 27.30 N ATOM 8604 CA GLN C 100 −32.544 54.338 −98.434 1.00 26.51 C ATOM 8605 CB GLN C 100 −33.993 54.558 −98.856 1.00 26.96 C ATOM 8606 CG GLN C 100 −34.689 53.306 −99.343 1.00 28.55 C ATOM 8607 CD GLN C 100 −35.862 53.607 −100.243 1.00 29.42 C ATOM 8608 OE1 GLN C 100 −35.713 54.251 −101.280 1.00 30.57 O ATOM 8609 NE2 GLN C 100 −37.040 53.129 −99.859 1.00 30.28 N ATOM 8610 C GLN C 100 −31.870 55.671 −98.224 1.00 26.03 C ATOM 8611 O GLN C 100 −32.316 56.484 −97.410 1.00 25.18 O ATOM 8612 N LEU C 101 −30.798 55.901 −98.968 1.00 26.45 N ATOM 8613 CA LEU C 101 −29.941 57.057 −98.722 1.00 27.97 C ATOM 8614 CB LEU C 101 −28.505 56.593 −98.436 1.00 27.99 C ATOM 8615 CG LEU C 101 −28.368 55.382 −97.500 1.00 27.16 C ATOM 8616 CD1 LEU C 101 −27.138 54.572 −97.859 1.00 27.13 C ATOM 8617 CD2 LEU C 101 −28.370 55.755 −96.024 1.00 26.08 C ATOM 8618 C LEU C 101 −29.974 58.062 −99.871 1.00 28.06 C ATOM 8619 O LEU C 101 −29.915 57.679 −101.038 1.00 27.13 O ATOM 8620 N PHE C 102 −30.072 59.346 −99.537 1.00 29.69 N ATOM 8621 CA PHE C 102 −30.167 60.378 −100.575 1.00 33.44 C ATOM 8622 CB PHE C 102 −31.535 61.077 −100.557 1.00 32.33 C ATOM 8623 CG PHE C 102 −32.701 60.125 −100.490 1.00 32.63 C ATOM 8624 CD1 PHE C 102 −33.177 59.500 −101.644 1.00 32.65 C ATOM 8625 CE1 PHE C 102 −34.244 58.612 −101.588 1.00 31.50 C ATOM 8626 CZ PHE C 102 −34.847 58.344 −100.373 1.00 31.64 C ATOM 8627 CE2 PHE C 102 −34.381 58.954 −99.213 1.00 31.37 C ATOM 8628 CD2 PHE C 102 −33.316 59.837 −99.272 1.00 31.86 C ATOM 8629 C PHE C 102 −29.032 61.391 −100.511 1.00 35.80 C ATOM 8630 O PHE C 102 −28.613 61.919 −101.542 1.00 35.10 O ATOM 8631 N HIS C 103 −28.536 61.658 −99.307 1.00 38.94 N ATOM 8632 CA HIS C 103 −27.487 62.655 −99.137 1.00 43.09 C ATOM 8633 CB HIS C 103 −27.397 63.118 −97.689 1.00 48.26 C ATOM 8634 CG HIS C 103 −28.585 63.936 −97.251 1.00 53.46 C ATOM 8635 ND1 HIS C 103 −29.495 63.479 −96.365 1.00 55.09 N ATOM 8636 CE1 HIS C 103 −30.450 64.413 −96.185 1.00 55.96 C ATOM 8637 NE2 HIS C 103 −30.157 65.467 −96.969 1.00 57.55 N ATOM 8638 CD2 HIS C 103 −29.016 65.205 −97.643 1.00 54.72 C ATOM 8639 C HIS C 103 −26.175 62.137 −99.618 1.00 41.95 C ATOM 8640 O HIS C 103 −25.804 61.014 −99.293 1.00 42.13 O ATOM 8641 N PRO C 104 −25.463 62.937 −100.434 1.00 41.99 N ATOM 8642 CA PRO C 104 −24.143 62.520 −100.919 1.00 41.37 C ATOM 8643 CB PRO C 104 −23.622 63.759 −101.665 1.00 40.76 C ATOM 8644 CG PRO C 104 −24.603 64.860 −101.382 1.00 41.34 C ATOM 8645 CD PRO C 104 −25.898 64.206 −101.041 1.00 40.84 C ATOM 8646 C PRO C 104 −23.221 62.140 −99.759 1.00 41.48 C ATOM 8647 O PRO C 104 −22.396 61.236 −99.897 1.00 39.63 O ATOM 8648 N GLN C 105 −23.390 62.830 −98.628 1.00 43.46 N ATOM 8649 CA GLN C 105 −22.747 62.483 −97.358 1.00 44.79 C ATOM 8650 CB GLN C 105 −23.425 63.240 −96.206 1.00 46.42 C ATOM 8651 CG GLN C 105 −23.398 64.754 −96.325 1.00 48.08 C ATOM 8652 CD GLN C 105 −22.015 65.325 −96.087 1.00 49.62 C ATOM 8653 OE1 GLN C 105 −21.210 64.751 −95.340 1.00 50.45 O ATOM 8654 NE2 GLN C 105 −21.725 66.460 −96.724 1.00 48.01 N ATOM 8655 C GLN C 105 −22.837 60.972 −97.097 1.00 45.62 C ATOM 8656 O GLN C 105 −21.815 60.274 −97.063 1.00 46.32 O ATOM 8657 N GLU C 106 −24.073 60.491 −96.921 1.00 44.15 N ATOM 8658 CA GLU C 106 −24.382 59.074 −95.731 1.00 41.32 C ATOM 8659 CB GLU C 106 −25.896 58.875 −96.596 1.00 40.29 C ATOM 8660 CG GLU C 106 −26.559 59.649 −95.465 1.00 39.99 C ATOM 8661 CD GLU C 106 −28.049 59.849 −95.688 1.00 40.26 C ATOM 8662 OE1 GLU C 106 −28.532 59.557 −96.803 1.00 41.69 O ATOM 8663 OE2 GLU C 106 −28.743 60.310 −94.754 1.00 39.61 O ATOM 8664 C GLU C 106 −23.870 58.235 −97.902 1.00 41.34 C ATOM 8665 O GLU C 106 −23.121 57.276 −97.704 1.00 42.99 O ATOM 8666 N VAL C 107 −24.269 58.622 −99.115 1.00 39.66 N ATOM 8667 CA VAL C 107 −23.972 57.877 −100.347 1.00 38.41 C ATOM 8668 CB VAL C 107 −24.639 58.548 −101.585 1.00 37.86 C ATOM 8669 CG1 VAL C 107 −24.131 57.961 −102.890 1.00 37.14 C ATOM 8670 CG2 VAL C 107 −26.154 58.412 −101.514 1.00 37.14 C ATOM 8671 C VAL C 107 −22.466 57.643 −100.557 1.00 38.26 C ATOM 8672 O VAL C 107 −22.068 56.676 −101.207 1.00 38.57 O ATOM 8673 N SER C 108 −21.635 58.519 −99.994 1.00 37.54 N ATOM 8674 CA SER C 108 −20.190 58.290 −99.968 1.00 37.77 C ATOM 8675 CB SER C 108 −19.438 59.580 −99.638 1.00 39.12 C ATOM 8676 OG SER C 108 −19.795 60.612 −100.533 1.00 40.65 O ATOM 8677 C SER C 108 −19.807 57.198 −98.965 1.00 37.43 C ATOM 8678 O SER C 108 −19.113 56.237 −99.325 1.00 37.40 O ATOM 8679 N MET C 109 −20.272 57.345 −97.719 1.00 35.59 N ATOM 8680 CA MET C 109 −19.930 56.425 −96.628 1.00 34.79 C ATOM 8681 CB MET C 109 −20.690 56.790 −95.348 1.00 34.81 C ATOM 8682 C MET C 109 −20.170 54.957 −96.978 1.00 34.43 C ATOM 8683 O MET C 109 −19.394 54.090 −96.589 1.00 35.20 O ATOM 8684 N VAL C 110 −21.239 54.691 −97.722 1.00 33.61 N ATOM 8685 CA VAL C 110 −21.621 53.325 −98.086 1.00 32.92 C ATOM 8686 CB VAL C 110 −23.141 53.231 −98.367 1.00 31.39 C ATOM 8687 CG1 VAL C 110 −23.561 51.794 −98.634 1.00 30.90 C ATOM 8688 CG2 VAL C 110 −23.924 53.796 −97.198 1.00 30.43 C ATOM 8689 C VAL C 110 −20.812 52.831 −99.292 1.00 33.25 C ATOM 8690 O VAL C 110 −20.216 51.749 −99.259 1.00 31.84 O ATOM 8691 N ARG C 111 −20.799 53.641 −100.350 1.00 34.78 N ATOM 8692 CA ARG C 111 −20.051 53.351 −101.566 1.00 36.02 C ATOM 8693 CB ARG C 111 −19.971 54.606 −102.434 1.00 36.55 C ATOM 8694 CG ARG C 111 −19.657 54.362 −103.901 1.00 36.77 C ATOM 8695 CD ARG C 111 −19.758 55.660 −104.685 1.00 36.42 C ATOM 8696 NE ARG C 111 −21.122 55.943 −105.128 1.00 36.80 N ATOM 8697 CZ ARG C 111 −21.556 57.144 −105.512 1.00 37.60 C ATOM 8698 NH1 ARG C 111 −20.743 58.194 −105.487 1.00 37.77 N ATOM 8699 NH2 ARG C 111 −22.811 57.303 −105.915 1.00 36.75 N ATOM 8700 C ARG C 111 −18.655 52.853 −101.215 1.00 37.05 C ATOM 8701 O ARG C 111 −18.160 51.903 −101.826 1.00 37.08 O ATOM 8702 N ASN C 112 −18.049 53.481 −100.206 1.00 38.08 N ATOM 8703 CA ASN C 112 −16.736 53.076 −99.699 1.00 40.02 C ATOM 8704 CB ASN C 112 −15.988 54.270 −99.096 1.00 41.72 C ATOM 8705 CG ASN C 112 −15.295 55.120 −100.152 1.00 42.80 C ATOM 8706 OD1 ASN C 112 −15.923 55.580 −101.115 1.00 42.33 O ATOM 8707 ND2 ASN C 112 −13.991 55.339 −99.971 1.00 42.91 N ATOM 8708 C ASN C 112 −16.755 51.907 −98.711 1.00 39.75 C ATOM 8709 O ASN C 112 −15.795 51.144 −98.638 1.00 40.53 O ATOM 8710 N LEU C 113 −17.836 51.767 −97.950 1.00 39.68 N ATOM 8711 CA LEU C 113 −18.003 50.601 −97.075 1.00 39.46 C ATOM 8712 CB LEU C 113 −19.331 50.672 −96.319 1.00 38.50 C ATOM 8713 CG LEU C 113 −19.385 51.040 −94.836 1.00 38.16 C ATOM 8714 CD1 LEU C 113 −18.147 51.783 −94.350 1.00 38.15 C ATOM 8715 CD2 LEU C 113 −20.647 51.845 −94.576 1.00 38.78 C ATOM 8716 C LEU C 113 −17.940 49.308 −97.877 1.00 40.48 C ATOM 8717 O LEU C 113 −17.356 48.324 −97.422 1.00 39.85 O ATOM 8718 N ILE C 114 −18.539 49.330 −99.072 1.00 41.91 N ATOM 8719 CA ILE C 114 −18.600 48.168 −99.959 1.00 43.17 C ATOM 8720 CB ILE C 114 −19.279 48.513 −101.294 1.00 43.42 C ATOM 8721 CG1 ILE C 114 −20.686 49.084 −101.066 1.00 43.54 C ATOM 8722 CD1 ILE C 114 −21.669 48.122 −100.425 1.00 44.57 C ATOM 8723 CG2 ILE C 114 −19.295 47.297 −102.210 1.00 44.62 C ATOM 8724 C ILE C 114 −17.213 47.600 −100.243 1.00 45.69 C ATOM 8725 O ILE C 114 −16.956 46.415 −100.001 1.00 48.31 O ATOM 8726 N GLN C 115 −16.320 48.439 −100.766 1.00 46.36 N ATOM 8727 CA GLN C 115 −14.928 48.051 −100.885 1.00 46.86 C ATOM 8728 CB GLN C 115 −14.131 49.030 −101.771 1.00 47.82 C ATOM 8729 CG GLN C 115 −14.851 49.574 −103.011 1.00 50.21 C ATOM 8730 CD GLN C 115 −15.155 48.523 −104.078 1.00 50.48 C ATOM 8731 OE1 GLN C 115 −16.237 48.527 −104.669 1.00 50.88 O ATOM 8732 NE2 GLN C 115 −14.205 47.624 −104.329 1.00 49.47 N ATOM 8733 C GLN C 115 −14.371 48.042 −99.465 1.00 47.81 C ATOM 8734 O GLN C 115 −13.908 49.075 −98.978 1.00 49.86 O ATOM 8735 N LYS C 116 −14.474 46.893 −98.785 1.00 45.30 N ATOM 8736 CA LYS C 116 −13.889 46.703 −97.445 1.00 42.66 C ATOM 8737 CB LYS C 116 −13.435 48.040 −96.832 1.00 41.26 C ATOM 8738 C LYS C 116 −14.801 45.980 −96.455 1.00 41.25 C ATOM 8739 O LYS C 116 −15.328 44.901 −96.734 1.00 39.67 O ATOM 8740 N ASP C 117 −14.957 46.614 −95.294 1.00 41.25 N ATOM 8741 CA ASP C 117 −15.666 46.095 −94.126 1.00 40.39 C ATOM 8742 CB ASP C 117 −15.621 47.157 −93.018 1.00 41.17 C ATOM 8743 CG ASP C 117 −15.280 46.580 −91.674 1.00 41.70 C ATOM 8744 OD1 ASP C 117 −14.361 45.738 −91.605 1.00 42.14 O ATOM 8745 OD2 ASP C 117 −15.916 46.983 −90.681 1.00 42.34 O ATOM 8746 C ASP C 117 −17.124 45.756 −94.406 1.00 38.57 C ATOM 8747 O ASP C 117 −17.633 44.734 −93.933 1.00 38.11 O ATOM 8748 N ARG C 118 −17.783 46.636 −95.165 1.00 36.88 N ATOM 8749 CA ARG C 118 −19.240 46.615 −95.394 1.00 35.49 C ATOM 8750 CB ARG C 118 −19.681 45.363 −96.162 1.00 36.51 C ATOM 8751 CG ARG C 118 −18.880 45.086 −97.426 1.00 38.55 C ATOM 8752 CD ARG C 118 −19.545 44.020 −98.276 1.00 41.03 C ATOM 8753 NE ARG C 118 −20.128 42.966 −97.452 1.00 43.54 N ATOM 8754 CZ ARG C 118 −19.554 41.794 −97.206 1.00 45.75 C ATOM 8755 NH1 ARG C 118 −18.372 41.498 −97.736 1.00 47.47 N ATOM 8756 NH2 ARG C 118 −20.173 40.909 −96.437 1.00 46.95 N ATOM 8757 C ARG C 118 −20.067 46.792 −94.116 1.00 33.13 C ATOM 8758 O ARG C 118 −21.292 46.671 −94.143 1.00 31.84 O ATOM 8759 N THR C 119 −19.392 47.084 −93.004 1.00 31.69 N ATOM 8760 CA THR C 119 −20.077 47.266 −91.726 1.00 30.26 C ATOM 8761 CB THR C 119 −19.660 46.235 −90.624 1.00 30.53 C ATOM 8762 OG1 THR C 119 −18.729 46.826 −89.717 1.00 31.51 O ATOM 8763 CG2 THR C 119 −19.037 44.974 −91.208 1.00 31.29 C ATOM 8764 C THR C 119 −19.934 48.691 −91.210 1.00 28.53 C ATOM 8765 O THR C 119 −18.861 49.296 −91.287 1.00 27.14 O ATOM 8766 N PHE C 120 −21.053 49.206 −90.703 1.00 27.60 N ATOM 8767 CA PHE C 120 −21.149 50.507 −90.049 1.00 26.17 C ATOM 8768 CB PHE C 120 −22.032 51.443 −90.879 1.00 26.07 C ATOM 8769 CG PHE C 120 −23.397 50.877 −91.190 1.00 26.24 C ATOM 8770 CD1 PHE C 120 −23.573 49.978 −92.247 1.00 25.85 C ATOM 8771 CE1 PHE C 120 −24.823 49.447 −92.527 1.00 25.60 C ATOM 8772 CZ PHE C 120 −25.918 49.820 −91.756 1.00 25.57 C ATOM 8773 CE2 PHE C 120 −25.759 50.714 −90.704 1.00 25.27 C ATOM 8774 CD2 PHE C 120 −24.509 51.237 −90.422 1.00 25.34 C ATOM 8775 C PHE C 120 −21.760 50.264 −88.667 1.00 25.30 C ATOM 8776 O PHE C 120 −22.143 49.138 −88.352 1.00 24.86 O ATOM 8777 N ALA C 121 −21.852 51.311 −87.850 1.00 24.92 N ATOM 8778 CA ALA C 121 −22.345 51.191 −86.473 1.00 24.65 C ATOM 8779 CB ALA C 121 −21.350 51.813 −85.507 1.00 24.77 C ATOM 8780 C ALA C 121 −23.728 51.816 −86.278 1.00 24.74 C ATOM 8781 O ALA C 121 −23.986 52.925 −86.738 1.00 24.49 O ATOM 8782 N VAL C 122 −24.615 51.096 −85.596 1.00 25.32 N ATOM 8783 CA VAL C 122 −25.926 51.634 −85.237 1.00 26.25 C ATOM 8784 CB VAL C 122 −27.081 50.715 −85.680 1.00 25.92 C ATOM 8785 CG1 VAL C 122 −28.417 51.378 −85.406 1.00 26.44 C ATOM 8786 CG2 VAL C 122 −26.972 50.385 −87.157 1.00 26.11 C ATOM 8787 C VAL C 122 −25.982 51.848 −83.727 1.00 27.59 C ATOM 8788 O VAL C 122 −25.592 50.972 −82.951 1.00 27.24 O ATOM 8789 N LEU C 123 −26.474 53.018 −83.324 1.00 29.25 N ATOM 8790 CA LEU C 123 −26.419 53.444 −81.931 1.00 30.82 C ATOM 8791 CB LEU C 123 −25.783 54.832 −81.820 1.00 29.51 C ATOM 8792 CG LEU C 123 −24.360 55.018 −82.336 1.00 29.07 C ATOM 8793 CD1 LEU C 123 −23.845 56.394 −81.947 1.00 29.20 C ATOM 8794 CD2 LEU C 123 −23.435 53.933 −81.808 1.00 28.50 C ATOM 8795 C LEU C 123 −27.782 53.465 −81.261 1.00 33.34 C ATOM 8796 O LEU C 123 −28.766 53.932 −81.840 1.00 34.19 O ATOM 8797 N ALA C 124 −27.825 52.959 −80.032 1.00 35.85 N ATOM 8798 CA ALA C 124 −28.987 53.103 −79.171 1.00 38.62 C ATOM 8799 CB ALA C 124 −29.035 51.968 −78.155 1.00 38.02 C ATOM 8800 C ALA C 124 −28.875 54.446 −78.466 1.00 40.53 C ATOM 8801 O ALA C 124 −27.964 54.644 −77.666 1.00 44.94 O ATOM 8802 N TYR C 125 −29.780 55.374 −78.769 1.00 41.40 N ATOM 8803 CA TYR C 125 −29.725 56.709 −78.160 1.00 42.30 C ATOM 8804 CB TYR C 125 −30.151 57.799 −79.152 1.00 40.91 C ATOM 8805 CG TYR C 125 −29.217 57.965 −80.331 1.00 40.53 C ATOM 8806 CD1 TYR C 125 −27.931 58.491 −80.161 1.00 39.84 C ATOM 8807 CE1 TYR C 125 −27.066 58.640 −81.240 1.00 38.90 C ATOM 8808 CZ TYR C 125 −27.484 58.267 −82.513 1.00 38.48 C ATOM 8809 OH TYR C 125 −26.631 58.418 −83.580 1.00 36.52 O ATOM 8810 CE2 TYR C 125 −28.758 57.747 −82.711 1.00 39.63 C ATOM 8811 CD2 TYR C 125 −29.617 57.599 −81.624 1.00 40.31 C ATOM 8812 C TYR C 125 −30.533 56.812 −76.859 1.00 44.58 C ATOM 8813 O TYR C 125 −31.759 56.627 −75.855 1.00 44.83 O ATOM 8814 N SER C 126 −29.826 57.102 −75.761 1.00 45.59 N ATOM 8815 CA SER C 126 −30.431 57.302 −74.436 1.00 43.75 C ATOM 8816 CB SER C 126 −29.397 57.050 −73.333 1.00 41.82 C ATOM 8817 C SER C 126 −31.004 58.712 −74.303 1.00 42.91 C ATOM 8818 O SER C 126 −30.502 59.659 −74.914 1.00 42.27 O ATOM 8819 N GLU C 132 −26.021 61.137 −75.343 1.00 43.59 N ATOM 8820 CA GLU C 132 −26.690 60.542 −76.504 1.00 45.97 C ATOM 8821 CB GLU C 132 −26.101 61.083 −77.818 1.00 44.64 C ATOM 8822 C GLU C 132 −26.729 58.987 −76.500 1.00 48.41 C ATOM 8823 O GLU C 132 −27.804 58.398 −76.355 1.00 49.32 O ATOM 8824 N ALA C 133 −25.575 58.328 −76.654 1.00 46.65 N ATOM 8825 CA ALA C 133 −25.551 56.863 −76.792 1.00 43.70 C ATOM 8826 CB ALA C 133 −25.494 56.477 −78.260 1.00 43.89 C ATOM 8827 C ALA C 133 −24.426 56.169 −76.016 1.00 43.42 C ATOM 8828 O ALA C 133 −23.261 56.563 −76.103 1.00 44.48 O ATOM 8829 N GLN C 134 −24.787 55.125 −75.269 1.00 42.44 N ATOM 8830 CA GLN C 134 −23.823 54.343 −74.483 1.00 41.41 C ATOM 8831 CB GLN C 134 −24.371 54.054 −73.074 1.00 42.23 C ATOM 8832 CG GLN C 134 −24.166 55.157 −72.038 1.00 43.70 C ATOM 8833 CD GLN C 134 −24.993 56.416 −72.303 1.00 45.10 C ATOM 8834 OE1 GLN C 134 −26.127 56.355 −72.800 1.00 43.96 O ATOM 8835 NE2 GLN C 134 −24.424 57.571 −71.960 1.00 45.83 N ATOM 8836 C GLN C 134 −23.469 53.021 −75.171 1.00 40.10 C ATOM 8837 O GLN C 134 −22.362 52.501 −75.003 1.00 39.00 O ATOM 8838 N PHE C 135 −24.422 52.482 −75.933 1.00 38.05 N ATOM 8839 CA PHE C 135 −24.280 51.166 −76.558 1.00 36.00 C ATOM 8840 CB PHE C 135 −25.036 50.103 −75.744 1.00 36.42 C ATOM 8841 CG PHE C 135 −24.577 49.966 −74.320 1.00 36.89 C ATOM 8842 CD1 PHE C 135 −23.482 49.164 −73.999 1.00 38.10 C ATOM 8843 CE1 PHE C 135 −23.070 49.018 −72.679 1.00 38.43 C ATOM 8844 CZ PHE C 135 −23.763 49.668 −71.663 1.00 38.57 C ATOM 8845 CE2 PHE C 135 −24.861 50.462 −71.970 1.00 37.56 C ATOM 8846 CD2 PHE C 135 −25.268 50.600 −73.290 1.00 37.27 C ATOM 8847 C PHE C 135 −24.818 51.155 −77.996 1.00 34.21 C ATOM 8848 O PHE C 135 −25.520 52.085 −78.412 1.00 32.64 O ATOM 8849 N GLY C 136 −24.507 50.087 −78.734 1.00 32.17 N ATOM 8850 CA GLY C 136 −25.071 49.871 −80.067 1.00 31.45 C ATOM 8851 C GLY C 136 −24.712 48.529 −80.685 1.00 31.15 C ATOM 8852 O GLY C 136 −24.252 47.618 −79.994 1.00 31.58 O ATOM 8853 N THR C 137 −24.921 48.403 −81.993 1.00 30.40 N ATOM 8854 CA THR C 137 −24.688 47.131 −82.692 1.00 29.35 C ATOM 8855 CB THR C 137 −25.987 46.296 −82.776 1.00 29.68 C ATOM 8856 OG1 THR C 137 −26.523 46.114 −81.460 1.00 29.16 O ATOM 8857 CG2 THR C 137 −25.732 44.925 −83.391 1.00 29.83 C ATOM 8858 C THR C 137 −24.084 47.328 −84.096 1.00 28.10 C ATOM 8859 O THR C 137 −24.502 48.215 −84.844 1.00 26.91 O ATOM 8860 N THR C 138 −23.084 46.516 −84.434 1.00 26.94 N ATOM 8861 CA THR C 138 −22.524 46.544 −85.785 1.00 26.21 C ATOM 8862 CB THR C 138 −21.148 45.822 −85.915 1.00 25.19 C ATOM 8863 OG1 THR C 138 −21.306 44.398 −85.863 1.00 24.21 O ATOM 8864 CG2 THR C 138 −20.203 46.261 −84.816 1.00 25.25 C ATOM 8865 C THR C 138 −23.543 45.967 −86.753 1.00 26.12 C ATOM 8866 O THR C 138 −24.200 44.972 −86.461 1.00 26.31 O ATOM 8867 N ALA C 139 −23.706 46.632 −87.880 1.00 26.13 N ATOM 8868 CA ALA C 139 −24.556 46.135 −88.932 1.00 26.60 C ATOM 8869 CB ALA C 139 −24.763 47.043 −89.118 1.00 25.88 C ATOM 8870 C ALA C 139 −23.714 46.050 −90.198 1.00 27.70 C ATOM 8871 O ALA C 139 −23.032 47.008 −90.579 1.00 28.28 O ATOM 8872 N GLU C 140 −23.758 44.882 −90.827 1.00 28.49 N ATOM 8873 CA GLU C 140 −22.934 44.545 −91.978 1.00 29.34 C ATOM 8874 CB GLU C 140 −22.323 43.172 −91.727 1.00 31.67 C ATOM 8875 CG GLU C 140 −21.433 42.603 −92.817 1.00 34.37 C ATOM 8876 CD GLU C 140 −20.921 41.219 −92.444 1.00 36.96 C ATOM 8877 OE1 GLU C 140 −19.697 41.071 −92.186 1.00 38.02 O ATOM 8878 OE2 GLU C 140 −21.757 40.286 −92.371 1.00 37.76 O ATOM 8879 C GLU C 140 −23.821 44.484 −93.206 1.00 29.21 C ATOM 8880 O GLU C 140 −24.877 43.851 −93.176 1.00 29.56 O ATOM 8881 N ILE C 141 −23.408 45.144 −94.283 1.00 28.81 N ATOM 8882 CA ILE C 141 −24.227 45.178 −95.495 1.00 29.73 C ATOM 8883 CB ILE C 141 −23.852 46.353 −96.429 1.00 30.46 C ATOM 8884 CG1 ILE C 141 −24.121 47.701 −95.734 1.00 30.28 C ATOM 8885 CD1 ILE C 141 −23.317 48.862 −96.293 1.00 29.75 C ATOM 8886 CG2 ILE C 141 −24.619 46.253 −97.752 1.00 30.54 C ATOM 8887 C ILE C 141 −24.134 43.858 −96.255 1.00 30.00 C ATOM 8888 O ILE C 141 −23.038 43.427 −96.623 1.00 29.80 O ATOM 8889 N TYR C 142 −25.283 43.221 −96.482 1.00 30.40 N ATOM 8890 CA TYR C 142 −25.323 41.957 −97.218 1.00 31.32 C ATOM 8891 CB TYR C 142 −26.014 40.862 −96.398 1.00 29.57 C ATOM 8892 CG TYR C 142 −27.506 41.004 −96.187 1.00 28.51 C ATOM 8893 CD1 TYR C 142 −28.406 40.748 −97.220 1.00 27.98 C ATOM 8894 CE1 TYR C 142 −29.779 40.856 −97.020 1.00 28.15 C ATOM 8895 CZ TYR C 142 −30.272 41.188 −95.759 1.00 28.12 C ATOM 8896 OH TYR C 142 −31.625 41.281 −95.563 1.00 26.63 O ATOM 8897 CE2 TYR C 142 −29.399 41.430 −94.709 1.00 28.61 C ATOM 8898 CD2 TYR C 142 −28.023 41.332 −94.927 1.00 28.82 C ATOM 8899 C TYR C 142 −25.901 42.058 −98.640 1.00 33.15 C ATOM 8900 O TYR C 142 −25.771 41.128 −99.438 1.00 33.72 O ATOM 8901 N ALA C 143 −26.535 43.191 −98.937 1.00 35.54 N ATOM 8902 CA ALA C 143 −27.049 43.497 −100.278 1.00 36.57 C ATOM 8903 CB ALA C 143 −28.355 42.761 −100.550 1.00 36.21 C ATOM 8904 C ALA C 143 −27.221 45.010 −100.464 1.00 36.90 C ATOM 8905 O ALA C 143 −27.482 45.746 −99.507 1.00 35.45 O ATOM 8906 N TYR C 144 −27.081 45.454 −101.710 1.00 38.42 N ATOM 8907 CA TYR C 144 −26.893 46.862 −102.028 1.00 40.42 C ATOM 8908 CB TYR C 144 −25.449 47.278 −101.657 1.00 43.46 C ATOM 8909 CG TYR C 144 −24.820 48.338 −102.536 1.00 47.25 C ATOM 8910 CD1 TYR C 144 −24.117 47.987 −103.693 1.00 48.36 C ATOM 8911 CE1 TYR C 144 −23.545 48.953 −104.508 1.00 51.79 C ATOM 8912 CZ TYR C 144 −23.657 50.300 −104.161 1.00 53.84 C ATOM 8913 OH TYR C 144 −23.090 51.273 −104.973 1.00 55.41 O ATOM 8914 CE2 TYR C 144 −24.336 50.670 −103.006 1.00 52.20 C ATOM 8915 CD2 TYR C 144 −24.908 49.691 −102.202 1.00 50.07 C ATOM 8916 C TYR C 144 −27.205 47.117 −103.507 1.00 39.96 C ATOM 8917 O TYR C 144 −26.762 46.370 −104.375 1.00 38.42 O ATOM 8918 N ARG C 145 −28.001 48.150 −103.779 1.00 42.11 N ATOM 8919 CA ARG C 145 −28.187 48.659 −105.146 1.00 43.87 C ATOM 8920 CB ARG C 145 −29.554 48.272 −105.721 1.00 46.02 C ATOM 8921 CG ARG C 145 −29.481 47.611 −107.099 1.00 50.21 C ATOM 8922 CD ARG C 145 −30.379 48.242 −108.173 1.00 54.66 C ATOM 8923 NE ARG C 145 −31.570 48.930 −107.658 1.00 57.11 N ATOM 8924 CZ ARG C 145 −32.703 48.334 −107.289 1.00 57.24 C ATOM 8925 NH1 ARG C 145 −33.711 49.069 −106.835 1.00 58.20 N ATOM 8926 NH2 ARG C 145 −32.830 47.012 −107.353 1.00 57.69 N ATOM 8927 C ARG C 145 −28.031 50.177 −105.161 1.00 43.43 C ATOM 8928 O ARG C 145 −28.531 50.871 −104.267 1.00 43.07 O ATOM 8929 N GLU C 146 −27.319 50.683 −106.166 1.00 43.36 N ATOM 8930 CA GLU C 146 −27.093 52.117 −106.310 1.00 45.09 C ATOM 8931 CB GLU C 146 −25.593 52.449 −106.293 1.00 43.95 C ATOM 8932 C GLU C 146 −27.720 52.609 −107.602 1.00 46.46 C ATOM 8933 O GLU C 146 −27.135 52.459 −108.681 1.00 49.04 O ATOM 8934 N GLU C 147 −28.916 53.183 −107.496 1.00 46.21 N ATOM 8935 CA GLU C 147 −29.553 53.804 −408.652 1.00 44.75 C ATOM 8936 CB GLU C 147 −31.065 53.514 −108.709 1.00 45.96 C ATOM 8937 CG GLU C 147 −31.924 54.199 −107.658 1.00 45.13 C ATOM 8938 CD GLU C 147 −33.232 53.467 −107.419 1.00 46.42 C ATOM 8939 OE1 GLU C 147 −33.192 52.220 −107.276 1.00 47.50 O ATOM 8940 OE2 GLU C 147 −34.295 54.131 −107.363 1.00 43.58 O ATOM 8941 C GLU C 147 −29.248 55.295 −108.750 1.00 41.87 C ATOM 8942 O GLU C 147 −29.404 56.047 −107.788 1.00 38.52 O ATOM 8943 N GLN C 148 −28.759 55.687 −109.920 1.00 41.20 N ATOM 8944 CA GLN C 148 −28.613 57.081 −110.277 1.00 40.39 C ATOM 8945 CB GLN C 148 −27.132 57.519 −110.269 1.00 41.12 C ATOM 8946 CG GLN C 148 −26.246 56.980 −111.385 1.00 43.11 C ATOM 8947 CD GLN C 148 −25.808 55.547 −111.168 1.00 44.36 C ATOM 8948 OE1 GLN C 148 −24.765 55.291 −110.562 1.00 45.19 O ATOM 8949 NE2 GLN C 148 −26.601 54.601 −111.665 1.00 44.28 N ATOM 8950 C GLN C 148 −29.320 57.313 −111.616 1.00 39.24 C ATOM 8951 O GLN C 148 −28.692 57.519 −112.650 1.00 38.85 O ATOM 8952 N ASP C 149 −30.648 57.235 −111.571 1.00 39.67 N ATOM 8953 CA ASP C 149 −31.502 57.436 −112.743 1.00 40.69 C ATOM 8954 CB ASP C 149 −32.517 56.292 −112.895 1.00 43.61 C ATOM 8955 CG ASP C 149 −31.979 54.952 −112.386 1.00 49.87 C ATOM 8956 OD1 ASP C 149 −30.794 54.620 −112.650 1.00 52.14 O ATOM 8957 OD2 ASP C 149 −32.743 54.231 −111.705 1.00 52.17 O ATOM 8958 C ASP C 149 −32.217 58.772 −112.600 1.00 38.92 C ATOM 8959 O ASP C 149 −32.661 59.134 −111.502 1.00 37.90 O ATOM 8960 N PHE C 150 −32.327 59.493 −113.718 1.00 36.69 N ATOM 8961 CA PHE C 150 −32.687 60.917 −113.728 1.00 35.46 C ATOM 8962 CB PHE C 150 −34.036 61.169 −113.042 1.00 33.39 C ATOM 8963 CG PHE C 150 −35.157 60.334 −113.583 1.00 33.19 C ATOM 8964 CD1 PHE C 150 −35.706 60.603 −114.834 1.00 33.45 C ATOM 8965 CE1 PHE C 150 −36.742 59.823 −115.335 1.00 33.27 C ATOM 8966 CZ PHE C 150 −37.246 58.768 −114.583 1.00 32.45 C ATOM 8967 CE2 PHE C 150 −36.716 58.497 −113.335 1.00 32.32 C ATOM 8968 CD2 PHE C 150 −35.677 59.278 −112.839 1.00 33.23 C ATOM 8969 C PHE C 150 −31.575 61.770 −113.097 1.00 36.25 C ATOM 8970 O PHE C 150 −31.767 62.957 −112.814 1.00 36.43 O ATOM 8971 N GLY C 151 −30.409 61.155 −112.893 1.00 36.58 N ATOM 8972 CA GLY C 151 −29.270 61.811 −112.246 1.00 34.90 C ATOM 8973 C GLY C 151 −29.448 62.044 −110.755 1.00 33.84 C ATOM 8974 O GLY C 151 −28.720 62.848 −110.160 1.00 33.30 O ATOM 8975 N ILE C 152 −30.429 61.363 −110.160 1.00 32.13 N ATOM 8976 CA ILE C 152 −30.637 61.406 −108.721 1.00 31.89 C ATOM 8977 CB ILE C 152 −32.127 61.493 −108.345 1.00 30.79 C ATOM 8978 CG1 ILE C 152 −32.856 62.548 −109.186 1.00 30.30 C ATOM 8979 CD1 ILE C 152 −34.352 62.622 −108.930 1.00 29.31 C ATOM 8980 CG2 ILE C 152 −32.278 61.755 −106.849 1.00 30.35 C ATOM 8981 C ILE C 152 −30.091 60.116 −108.135 1.00 33.80 C ATOM 8982 O ILE C 152 −30.605 59.035 −108.439 1.00 35.82 O ATOM 8983 N GLU C 153 −29.063 60.232 −107.290 1.00 34.84 N ATOM 8984 CA GLU C 153 −28.411 59.065 −106.684 1.00 34.79 C ATOM 8985 CB GLU C 153 −26.949 59.353 −106.363 1.00 36.31 C ATOM 8986 CG GLU C 153 −26.131 59.739 −107.582 1.00 39.82 C ATOM 8987 CD GLU C 153 −24.649 59.825 −107.290 1.00 43.37 C ATOM 8988 OE1 GLU C 153 −24.243 59.583 −106.123 1.00 44.85 O ATOM 8989 OE2 GLU C 153 −23.889 60.137 −108.234 1.00 44.61 O ATOM 8990 C GLU C 153 −29.134 58.595 −105.438 1.00 33.65 C ATOM 8991 O GLU C 153 −29.287 59.343 −104.476 1.00 33.56 O ATOM 8992 N ILE C 154 −29.604 57.355 −105.483 1.00 32.43 N ATOM 8993 CA ILE C 154 −30.215 56.718 −104.337 1.00 31.76 C ATOM 8994 CB ILE C 154 −31.673 56.273 −104.623 1.00 32.87 C ATOM 8995 CG1 ILE C 154 −32.435 57.308 −105.488 1.00 32.76 C ATOM 8996 CD1 ILE C 154 −32.728 58.639 −104.826 1.00 32.18 C ATOM 8997 CG2 ILE C 154 −32.405 55.880 −103.330 1.00 32.47 C ATOM 8998 C ILE C 154 −29.398 55.479 −104.034 1.00 31.39 C ATOM 8999 O ILE C 154 −28.976 54.764 −104.941 1.00 31.52 O ATOM 9000 N VAL C 155 −29.164 55.235 −102.755 1.00 31.41 N ATOM 9001 CA VAL C 155 −28.539 53.995 −102.324 1.00 30.94 C ATOM 9002 CB VAL C 155 −27.162 54.241 −101.667 1.00 31.31 C ATOM 9003 CG1 VAL C 155 −26.637 52.973 −101.007 1.00 31.08 C ATOM 9004 CG2 VAL C 155 −26.166 54.747 −102.707 1.00 30.96 C ATOM 9005 C VAL C 155 −29.484 53.242 −101.394 1.00 30.09 C ATOM 9006 O VAL C 155 −29.902 53.759 −100.354 1.00 29.69 O ATOM 9007 N LYS C 156 −29.840 52.031 −101.808 1.00 29.50 N ATOM 9008 CA LYS C 156 −30.680 51.150 −101.014 1.00 29.58 C ATOM 9009 CB LYS C 156 −31.859 50.642 −101.845 1.00 30.39 C ATOM 9010 CG LYS C 156 −32.816 51.732 −102.324 1.00 31.48 C ATOM 9011 CD LYS C 156 −33.488 51.348 −103.640 1.00 31.80 C ATOM 9012 CE LYS C 156 −34.680 52.240 −103.951 1.00 32.18 C ATOM 9013 NZ LYS C 156 −35.867 51.951 −103.089 1.00 32.74 N ATOM 9014 C LYS C 156 −29.823 49.984 −100.546 1.00 29.44 C ATOM 9015 O LYS C 156 −29.136 49.355 −101.356 1.00 29.69 O ATOM 9016 N VAL C 157 −29.831 49.725 −99.238 1.00 28.28 N ATOM 9017 CA VAL C 157 −29.036 48.637 −98.667 1.00 27.93 C ATOM 9018 CB VAL C 157 −27.736 49.131 −97.955 1.00 27.95 C ATOM 9019 CG1 VAL C 157 −26.861 49.935 −98.903 1.00 28.20 C ATOM 9020 CG2 VAL C 157 −28.043 49.940 −96.703 1.00 27.87 C ATOM 9021 C VAL C 157 −29.849 47.797 −97.700 1.00 27.58 C ATOM 9022 O VAL C 157 −30.767 48.299 −97.052 1.00 27.79 O ATOM 9023 N LYS C 158 −29.506 46.514 −97.615 1.00 27.25 N ATOM 9024 CA LYS C 158 −30.030 45.636 −96.570 1.00 26.00 C ATOM 9025 CB LYS C 158 −30.719 44.415 −97.169 1.00 25.56 C ATOM 9026 CG LYS C 158 −31.850 44.722 −98.128 1.00 25.25 C ATOM 9027 CD LYS C 158 −32.649 43.464 −98.379 1.00 25.10 C ATOM 9028 CE LYS C 158 −33.308 43.465 −99.740 1.00 24.37 C ATOM 9029 NZ LYS C 158 −34.052 42.187 −99.868 1.00 24.08 N ATOM 9030 C LYS C 158 −28.880 45.183 −95.694 1.00 25.47 C ATOM 9031 O LYS C 158 −28.013 44.438 −96.141 1.00 25.56 O ATOM 9032 N ALA C 159 −28.863 45.656 −94.454 1.00 25.65 N ATOM 9033 CA ALA C 159 −27.842 45.259 −93.479 1.00 25.33 C ATOM 9034 CB ALA C 159 −27.205 46.486 −92.830 1.00 24.64 C ATOM 9035 C ALA C 159 −28.420 44.317 −92.416 1.00 24.69 C ATOM 9036 O ALA C 159 −29.635 44.219 −92.246 1.00 24.05 O ATOM 9037 N ILE C 160 −27.530 43.630 −91.711 1.00 24.44 N ATOM 9038 CA ILE C 160 −27.908 42.685 −90.672 1.00 24.38 C ATOM 9039 CB ILE C 160 −27.667 41.226 −91.141 1.00 25.17 C ATOM 9040 CG1 ILE C 160 −27.806 40.234 −89.978 1.00 25.46 C ATOM 9041 CD1 ILE C 160 −28.914 39.228 −90.175 1.00 25.97 C ATOM 9042 CG2 ILE C 160 −26.309 41.073 −91.825 1.00 25.25 C ATOM 9043 C ILE C 160 −27.089 42.995 −89.421 1.00 23.89 C ATOM 9044 O ILE C 160 −25.867 43.085 −89.489 1.00 24.71 O ATOM 9045 N GLY C 161 −27.755 43.182 −88.287 1.00 23.07 N ATOM 9046 CA GLY C 161 −27.051 43.395 −87.026 1.00 23.38 C ATOM 9047 C GLY C 161 −26.129 42.248 −86.647 1.00 23.57 C ATOM 9048 O GLY C 161 −26.519 41.089 −86.703 1.00 23.90 O ATOM 9049 N ARG C 162 −24.905 42.571 −86.249 1.00 24.16 N ATOM 9050 CA ARG C 162 −23.898 41.545 −85.976 1.00 25.00 C ATOM 9051 CB ARG C 162 −22.720 41.685 −86.948 1.00 26.49 C ATOM 9052 CG ARG C 162 −23.026 41.282 −88.388 1.00 27.30 C ATOM 9053 CD ARG C 162 −22.703 39.815 −88.624 1.00 29.10 C ATOM 9054 NE ARG C 162 −23.898 38.998 −88.825 1.00 29.73 N ATOM 9055 CZ ARG C 162 −24.210 38.399 −89.975 1.00 30.39 C ATOM 9056 NH1 ARG C 162 −23.421 38.513 −91.043 1.00 29.87 N ATOM 9057 NH2 ARG C 162 −25.314 37.677 −90.060 1.00 31.06 N ATOM 9058 C ARG C 162 −23.401 41.521 −84.523 1.00 24.40 C ATOM 9059 O ARG C 162 −23.617 40.549 −83.807 1.00 23.65 O ATOM 9060 N GLN C 163 −22.750 42.591 −84.087 1.00 24.57 N ATOM 9061 CA GLN C 163 −22.120 42.595 −82.766 1.00 25.63 C ATOM 9062 CB GLN C 163 −20.609 42.605 −82.914 1.00 25.11 C ATOM 9063 CG GLN C 163 −20.078 41.415 −83.667 1.00 25.11 C ATOM 9064 CD GLN C 163 −18.585 41.347 −83.603 1.00 25.26 C ATOM 9065 OE1 GLN C 163 −17.903 41.573 −84.600 1.00 26.94 O ATOM 9066 NE2 GLN C 163 −18.059 41.054 −82.425 1.00 25.03 N ATOM 9067 C GLN C 163 −22.541 43.738 −81.849 1.00 26.46 C ATOM 9068 O GLN C 163 −22.758 44.870 −82.295 1.00 26.85 O ATOM 9069 N ARG C 164 −22.626 43.445 −80.558 1.00 26.40 N ATOM 9070 CA ARG C 164 −22.943 44.477 −79.583 1.00 27.25 C ATOM 9071 CB ARG C 164 −23.707 43.881 −78.406 1.00 26.39 C ATOM 9072 CG ARG C 164 −24.895 43.028 −78.810 1.00 25.56 C ATOM 9073 CD ARG C 164 −25.554 42.384 −77.603 1.00 26.18 C ATOM 9074 NE ARG C 164 −24.654 41.491 −76.882 1.00 26.53 N ATOM 9075 CZ ARG C 164 −24.062 41.787 −75.727 1.00 27.04 C ATOM 9076 NH1 ARG C 164 −24.270 42.959 −75.140 1.00 26.44 N ATOM 9077 NH2 ARG C 164 −23.254 40.904 −75.155 1.00 27.72 N ATOM 9078 C ARG C 164 −21.667 45.175 −79.105 1.00 28.26 C ATOM 9079 O ARG C 164 −20.620 44.543 −78.936 1.00 28.97 O ATOM 9080 N PHE C 165 −21.747 46.482 −78.895 1.00 29.29 N ATOM 9081 CA PHE C 165 −20.581 47.226 −78.435 1.00 30.05 C ATOM 9082 CB PHE C 165 −19.810 47.827 −79.614 1.00 29.79 C ATOM 9083 CG PHE C 165 −20.638 48.708 −80.510 1.00 29.73 C ATOM 9084 CD1 PHE C 165 −21.121 49.934 −80.065 1.00 29.67 C ATOM 9085 CE1 PHE C 165 −21.872 50.747 −80.894 1.00 29.44 C ATOM 9086 CZ PHE C 165 −22.146 50.351 −82.187 1.00 29.09 C ATOM 9087 CE2 PHE C 165 −21.661 49.141 −82.649 1.00 29.88 C ATOM 9088 CD2 PHE C 165 −20.908 48.327 −81.814 1.00 30.04 C ATOM 9089 C PHE C 165 −20.903 48.299 −77.407 1.00 30.89 C ATOM 9090 O PHE C 165 −22.033 48.791 −77.334 1.00 31.38 O ATOM 9091 N LYS C 166 −19.886 48.640 −76.620 1.00 32.19 N ATOM 9092 CA LYS C 166 −19.914 49.730 −75.648 1.00 33.48 C ATOM 9093 CB LYS C 166 −19.151 49.285 −74.391 1.00 34.00 C ATOM 9094 CG LYS C 166 −18.925 50.319 −73.298 1.00 35.23 C ATOM 9095 CD LYS C 166 −17.575 50.062 −72.624 1.00 36.59 C ATOM 9096 CE LYS C 166 −17.667 49.955 −71.102 1.00 36.25 C ATOM 9097 NZ LYS C 166 −17.831 51.270 −70.431 1.00 36.47 N ATOM 9098 C LYS C 166 −19.246 50.954 −76.302 1.00 34.69 C ATOM 9099 O LYS C 166 −18.168 50.844 −76.903 1.00 34.97 O ATOM 9100 N VAL C 167 −19.903 52.107 −76.215 1.00 35.40 N ATOM 9101 CA VAL C 167 −19.360 53.345 −76.776 1.00 35.13 C ATOM 9102 CB VAL C 167 −20.466 54.414 −76.986 1.00 35.52 C ATOM 9103 CG1 VAL C 167 −19.868 55.762 −77.384 1.00 34.46 C ATOM 9104 CG2 VAL C 167 −21.484 53.942 −78.018 1.00 34.56 C ATOM 9105 C VAL C 167 −18.292 53.885 −75.838 1.00 34.38 C ATOM 9106 O VAL C 167 −18.495 53.932 −74.635 1.00 33.43 O ATOM 9107 N LEU C 168 −17.150 54.268 −76.392 1.00 35.94 N ATOM 9108 CA LEU C 168 −16.124 54.947 −75.614 1.00 37.92 C ATOM 9109 CB LEU C 168 −14.759 54.283 −75.805 1.00 37.39 C ATOM 9110 CG LEU C 168 −14.734 52.759 −75.598 1.00 36.53 C ATOM 9111 CD1 LEU C 168 −13.527 52.134 −76.275 1.00 36.10 C ATOM 9112 CD2 LEU C 168 −14.782 52.370 −74.126 1.00 36.84 C ATOM 9113 C LEU C 168 −16.116 56.441 −75.955 1.00 40.12 C ATOM 9114 O LEU C 168 −16.571 57.247 −75.146 1.00 41.66 O ATOM 9115 N GLU C 169 −15.648 56.810 −77.149 1.00 41.72 N ATOM 9116 CA GLU C 169 −15.775 58.202 −77.611 1.00 43.81 C ATOM 9117 CB GLU C 169 −14.410 58.903 −77.707 1.00 45.99 C ATOM 9118 CG GLU C 169 −14.503 60.430 −77.655 1.00 48.51 C ATOM 9119 CD GLU C 169 −13.290 61.139 −78.246 1.00 50.65 C ATOM 9120 OE1 GLU C 169 −12.150 60.804 −77.856 1.00 53.21 O ATOM 9121 OE2 GLU C 169 −13.474 62.047 −79.090 1.00 49.34 O ATOM 9122 C GLU C 169 −16.536 58.342 −78.932 1.00 44.72 C ATOM 9123 O GLU C 169 −16.589 57.413 −79.741 1.00 44.57 O ATOM 9124 N LEU C 170 −17.112 59.524 −79.136 1.00 46.40 N ATOM 9125 CA LEU C 170 −17.861 59.848 −80.348 1.00 47.12 C ATOM 9126 CB LEU C 170 −19.354 59.899 −80.037 1.00 45.61 C ATOM 9127 CG LEU C 170 −20.232 58.898 −80.767 1.00 44.60 C ATOM 9128 CD1 LEU C 170 −21.443 58.565 −79.912 1.00 44.62 C ATOM 9129 CD2 LEU C 170 −20.644 59.474 −82.119 1.00 44.18 C ATOM 9130 C LEU C 170 −17.417 61.172 −80.976 1.00 48.21 C ATOM 9131 O LEU C 170 −17.845 62.247 −80.545 1.00 47.65 O ATOM 9132 N GLU C 171 −16.569 61.083 −82.001 1.00 50.90 N ATOM 9133 CA GLU C 171 −16.040 62.272 −82.693 1.00 52.69 C ATOM 9134 CB GLU C 171 −14.488 62.267 −82.715 1.00 53.99 C ATOM 9135 CG GLU C 171 −13.819 61.165 −83.549 1.00 53.64 C ATOM 9136 CD GLU C 171 −13.494 59.893 −82.765 1.00 53.43 C ATOM 9137 OE1 GLU C 171 −14.242 59.531 −81.828 1.00 54.53 O ATOM 9138 OE2 GLU C 171 −12.489 59.232 −83.104 1.00 52.39 O ATOM 9139 C GLU C 171 −16.638 62.471 −84.103 1.00 52.83 C ATOM 9140 O GLU C 171 −17.198 61.531 −84.691 1.00 52.05 O ATOM 9141 N ARG C 172 −16.528 63.698 −84.623 1.00 52.92 N ATOM 9142 CA ARG C 172 −17.066 64.053 −85.948 1.00 51.11 C ATOM 9143 CB ARG C 172 −18.264 65.006 −85.825 1.00 50.87 C ATOM 9144 CG ARG C 172 −19.466 64.419 −85.090 1.00 52.76 C ATOM 9145 CD ARG C 172 −20.525 65.463 −84.750 1.00 53.58 C ATOM 9146 NE ARG C 172 −19.957 66.682 −84.163 1.00 55.14 N ATOM 9147 CZ ARG C 172 −20.139 67.914 −84.643 1.00 55.64 C ATOM 9148 NH1 ARG C 172 −20.898 68.117 −85.716 1.00 56.60 N ATOM 9149 NH2 ARG C 172 −19.573 68.954 −84.042 1.00 54.00 N ATOM 9150 C ARG C 172 −15.995 64.673 −86.835 1.00 48.04 C ATOM 9151 O ARG C 172 −16.096 64.633 −88.058 1.00 45.64 O ATOM 9152 N GLY C 176 −20.324 65.745 −92.321 1.00 49.15 N ATOM 9153 CA ILE C 177 −21.169 65.507 −91.148 1.00 51.24 C ATOM 9154 C ILE C 177 −21.411 64.033 −90.836 1.00 51.21 C ATOM 9155 O ILE C 177 −22.501 63.654 −90.398 1.00 50.27 O ATOM 9156 N ILE C 177 −20.396 63.202 −91.069 1.00 50.57 N ATOM 9157 CA ILE C 177 −20.480 61.771 −90.772 1.00 50.37 C ATOM 9158 CB ILE C 177 −19.938 60.890 −91.934 1.00 50.71 C ATOM 9159 CG1 ILE C 177 −20.515 61.339 −93.287 1.00 50.99 C ATOM 9160 CD1 ILE C 177 −22.010 61.129 −93.452 1.00 50.09 C ATOM 9161 CG2 ILE C 177 −20.226 59.407 −91.692 1.00 49.96 C ATOM 9162 C ILE C 177 −19.723 61.477 −89.481 1.00 49.33 C ATOM 9163 O ILE C 177 −18.657 62.046 −89.230 1.00 48.56 O ATOM 9164 N GLN C 178 −20.293 60.596 −88.663 1.00 48.61 N ATOM 9165 CA GLN C 178 −19.725 60.263 −87.364 1.00 47.75 C ATOM 9166 CB GLN C 178 −20.835 60.038 −86.332 1.00 48.09 C ATOM 9167 CG GLN C 178 −21.364 61.307 −85.680 1.00 48.01 C ATOM 9168 CD GLN C 178 −22.824 61.194 −85.274 1.00 47.73 C ATOM 9169 OE1 GLN C 178 −23.429 60.123 −85.366 1.00 46.07 O ATOM 9170 NE2 GLN C 178 −23.399 62.307 −84.828 1.00 48.06 N ATOM 9171 C GLN C 178 −18.838 59.031 −87.444 1.00 46.30 C ATOM 9172 O GLN C 178 −19.084 58.123 −88.236 1.00 45.88 O ATOM 9173 N GLN C 179 −17.789 59.023 −86.632 1.00 44.53 N ATOM 9174 CA GLN C 179 −17.014 57.823 −86.415 1.00 43.23 C ATOM 9175 CB GLN C 179 −15.599 57.955 −86.988 1.00 43.21 C ATOM 9176 CG GLN C 179 −15.579 58.171 −88.500 1.00 44.69 C ATOM 9177 CD GLN C 179 −14.678 57.193 −89.248 1.00 45.70 C ATOM 9178 OE1 GLN C 179 −14.749 55.979 −89.047 1.00 46.32 O ATOM 9179 NE2 GLN C 179 −13.844 57.721 −90.138 1.00 45.48 N ATOM 9180 C GLN C 179 −17.008 57.548 −84.921 1.00 43.10 C ATOM 9181 O GLN C 179 −16.769 58.458 −84.120 1.00 42.92 O ATOM 9182 N ALA C 180 −17.313 56.300 −84.553 1.00 41.97 N ATOM 9183 CA ALA C 180 −17.444 55.901 −83.150 1.00 40.29 C ATOM 9184 CB ALA C 180 −18.802 55.260 −82.902 1.00 39.36 C ATOM 9185 C ALA C 180 −16.316 54.983 −82.665 1.00 39.26 C ATOM 9186 O ALA C 180 −16.019 53.950 −83.285 1.00 35.43 O ATOM 9187 N LYS C 181 −15.686 55.397 −81.561 1.00 39.95 N ATOM 9188 CA LYS C 181 −14.758 54.552 −80.804 1.00 40.09 C ATOM 9189 CB LYS C 181 −13.837 55.402 −79.923 1.00 39.76 C ATOM 9190 CG LYS C 181 −13.090 54.615 −78.859 1.00 39.65 C ATOM 9191 CD LYS C 181 −11.591 54.811 −78.975 1.00 40.94 C ATOM 9192 CE LYS C 181 −11.007 53.864 −80.008 1.00 41.69 C ATOM 9193 NZ LYS C 181 −9.990 54.543 −80.858 1.00 42.44 N ATOM 9194 C LYS C 181 −15.559 53.554 −79.965 1.00 40.17 C ATOM 9195 O LYS C 181 −16.403 53.942 −79.150 1.00 40.86 O ATOM 9196 N VAL C 182 −15.277 52.271 −80.161 1.00 38.75 N ATOM 9197 CA VAL C 182 −16.205 51.224 −79.777 1.00 37.12 C ATOM 9198 CB VAL C 182 −17.132 50.906 −80.976 1.00 36.68 C ATOM 9199 CG1 VAL C 182 −17.315 49.412 −81.197 1.00 35.97 C ATOM 9200 CG2 VAL C 182 −18.456 51.635 −80.813 1.00 36.78 C ATOM 9201 C VAL C 182 −15.495 49.981 −79.259 1.00 36.86 C ATOM 9202 O VAL C 182 −14.634 49.426 −79.941 1.00 38.01 O ATOM 9203 N GLN C 183 −15.844 49.566 −78.040 1.00 36.65 N ATOM 9204 CA GLN C 183 −15.348 48.298 −77.473 1.00 36.94 C ATOM 9205 CB GLN C 183 −14.973 48.448 −75.987 1.00 36.31 C ATOM 9206 C GLN C 183 −16.364 47.160 −77.671 1.00 36.22 C ATOM 9207 O GLN C 183 −17.496 47.224 −77.173 1.00 35.00 O ATOM 9208 N ILE C 184 −15.961 46.131 −78.413 1.00 35.08 N ATOM 9209 CA ILE C 184 −16.834 44.983 −78.657 1.00 34.76 C ATOM 9210 CB ILE C 184 −16.176 43.945 −79.598 1.00 33.98 C ATOM 9211 CG1 ILE C 184 −15.836 44.571 −80.965 1.00 33.22 C ATOM 9212 CD1 ILE C 184 −17.026 45.073 −81.762 1.00 32.20 C ATOM 9213 CG2 ILE C 184 −17.068 42.718 −79.753 1.00 33.18 C ATOM 9214 C ILE C 184 −17.242 44.306 −77.344 1.00 25.47 C ATOM 9215 O ILE C 184 −16.394 44.026 −76.477 1.00 35.62 O ATOM 9216 N LEU C 185 −18.542 44.060 −77.187 1.00 34.36 N ATOM 9217 CA LEU C 185 −19.016 43.268 −76.051 1.00 33.04 C ATOM 9218 CB LEU C 185 −20.361 43.773 −75.532 1.00 30.76 C ATOM 9219 CG LEU C 185 −20.406 45.235 −75.088 1.00 29.65 C ATOM 9220 CD1 LEU C 185 −21.827 45.632 −74.724 1.00 29.29 C ATOM 9221 CD2 LEU C 185 −19.437 45.526 −73.947 1.00 28.76 C ATOM 9222 C LEU C 185 −19.089 41.798 −76.447 1.00 33.63 C ATOM 9223 O LEU C 185 −19.683 41.458 −77.469 1.00 34.03 O ATOM 9224 N PRO C 186 −18.451 40.926 −75.652 1.00 34.23 N ATOM 9225 CA PRO C 186 −18.408 39.485 −75.905 1.00 34.38 C ATOM 9226 CB PRO C 186 −17.405 38.988 −74.857 1.00 35.52 C ATOM 9227 CG PRO C 186 −17.492 39.981 −73.743 1.00 34.59 C ATOM 9228 CD PRO C 186 −17.712 41.296 −74.429 1.00 34.50 C ATOM 9229 C PRO C 186 −19.761 38.790 −75.690 1.00 33.47 C ATOM 9230 O PRO C 186 −20.477 39.118 −74.733 1.00 34.19 O ATOM 9231 N GLU C 187 −20.107 37.840 −76.563 1.00 31.35 N ATOM 9232 CA GLU C 187 −21.272 36.982 −76.311 1.00 30.42 C ATOM 9233 CB GLU C 187 −21.802 36.334 −77.586 1.00 30.44 C ATOM 9234 CG GLU C 187 −23.054 35.488 −77.376 1.00 29.89 C ATOM 9235 CD GLU C 187 −24.313 36.317 −77.192 1.00 30.44 C ATOM 9236 OE1 GLU C 187 −24.320 37.505 −77.598 1.00 30.04 O ATOM 9237 OE2 GLU C 187 −25.303 35.774 −76.648 1.00 30.77 O ATOM 9238 C GLU C 187 −20.908 35.915 −75.294 1.00 30.11 C ATOM 9239 O GLU C 187 −20.077 35.033 −75.564 1.00 30.06 O ATOM 9240 N CYS C 188 −21.537 36.006 −74.127 1.00 28.63 N ATOM 9241 CA CYS C 188 −21.168 35.204 −72.983 1.00 26.93 C ATOM 9242 CB CYS C 188 −21.512 35.968 −71.714 1.00 28.99 C ATOM 9243 SG CYS C 188 −21.877 34.930 −70.289 1.00 34.68 S ATOM 9244 C CYS C 188 −21.846 33.840 −73.036 1.00 24.92 C ATOM 9245 O CYS C 188 −23.052 33.729 −72.857 1.00 23.99 O ATOM 9246 N VAL C 189 −21.057 32.807 −73.318 1.00 23.98 N ATOM 9247 CA VAL C 189 −21.579 31.443 −73.492 1.00 23.07 C ATOM 9248 CB VAL C 189 −21.122 30.798 −74.824 1.00 22.52 C ATOM 9249 CG1 VAL C 189 −21.564 31.643 −76.008 1.00 21.63 C ATOM 9250 CG2 VAL C 189 −19.612 30.592 −74.851 1.00 23.26 C ATOM 9251 C VAL C 189 −21.200 30.547 −72.315 1.00 22.77 C ATOM 9252 O VAL C 189 −20.024 30.478 −71.917 1.00 23.03 O ATOM 9253 N LEU C 190 −22.199 29.875 −71.746 1.00 21.77 N ATOM 9254 CA LEU C 190 −21.979 29.056 −70.557 1.00 21.26 C ATOM 9255 CB LEU C 190 −22.724 29.634 −69.347 1.00 20.89 C ATOM 9256 CG LEU C 190 −22.598 31.141 −69.113 1.00 20.79 C ATOM 9257 CD1 LEU C 190 −23.528 31.577 −67.999 1.00 20.74 C ATOM 9258 CD2 LEU C 190 −21.164 31.537 −68.807 1.00 21.18 C ATOM 9259 C LEU C 190 −22.406 27.617 −70.794 1.00 20.89 C ATOM 9260 O LEU C 190 −23.376 27.380 −71.509 1.00 21.01 O ATOM 9261 N PRO C 191 −21.682 26.650 −70.189 1.00 20.38 N ATOM 9262 CA PRO C 191 −22.109 25.255 −70.195 1.00 20.44 C ATOM 9263 CB PRO C 191 −20.981 24.551 −69.447 1.00 20.07 C ATOM 9264 CG PRO C 191 −20.402 25.599 −68.566 1.00 19.92 C ATOM 9265 CD PRO C 191 −20.469 26.847 −69.377 1.00 20.04 C ATOM 9266 C PRO C 191 −23.426 25.127 −69.431 1.00 20.86 C ATOM 9267 O PRO C 191 −23.985 26.147 −69.026 1.00 21.55 O ATOM 9268 N SER C 192 −23.932 23.910 −69.241 1.00 21.13 N ATOM 9269 CA SER C 192 −25.111 23.727 −68.394 1.00 22.07 C ATOM 9270 CB SER C 192 −25.664 22.315 −68.525 1.00 22.98 C ATOM 9271 OG SER C 192 −24.936 21.422 −67.685 1.00 24.06 O ATOM 9272 C SER C 192 −24.719 23.982 −66.941 1.00 22.43 C ATOM 9273 O SER C 192 −23.532 23.915 −66.591 1.00 22.77 O ATOM 9274 N THR C 193 −25.703 24.245 −66.085 1.00 22.61 N ATOM 9275 CA THR C 193 −25.416 24.386 −64.660 1.00 23.04 C ATOM 9276 CB THR C 193 −26.633 24.792 −63.808 1.00 23.22 C ATOM 9277 OG1 THR C 193 −27.727 25.222 −64.630 1.00 23.73 O ATOM 9278 CG2 THR C 193 −26.226 25.905 −62.879 1.00 23.65 C ATOM 9279 C THR C 193 −24.838 23.113 −64.050 1.00 22.96 C ATOM 9280 O THR C 193 −24.161 23.172 −63.022 1.00 23.90 O ATOM 9281 N MET C 194 −25.095 21.974 −64.685 1.00 21.65 N ATOM 9282 CA MET C 194 −24.715 20.684 −64.121 1.00 20.83 C ATOM 9283 CB MET C 194 −25.774 19.642 −64.458 1.00 20.93 C ATOM 9284 CG MET C 194 −27.157 19.991 −63.933 1.00 20.79 C ATOM 9285 SD MET C 194 −27.328 19.717 −62.159 1.00 21.07 S ATOM 9286 CE MET C 194 −26.579 21.191 −61.449 1.00 20.41 C ATOM 9287 C MET C 194 −23.339 20.190 −64.543 1.00 20.40 C ATOM 9288 O MET C 194 −22.687 19.459 −63.809 1.00 20.13 O ATOM 9289 N SER C 195 −22.901 20.587 −65.730 1.00 20.58 N ATOM 9290 CA SER C 195 −21.594 20.181 −66.259 1.00 20.71 C ATOM 9291 CB SER C 195 −21.293 20.977 −67.535 1.00 20.64 C ATOM 9292 OG SER C 195 −20.819 22.280 −67.216 1.00 20.72 O ATOM 9293 C SER C 195 −20.417 20.328 −65.265 1.00 20.41 C ATOM 9294 O SER C 195 −19.372 19.739 −65.460 1.00 20.38 O ATOM 9295 N ALA C 196 −20.594 21.131 −64.221 1.00 20.87 N ATOM 9296 CA ALA C 196 −19.528 21.426 −63.257 1.00 21.28 C ATOM 9297 CB ALA C 196 −19.689 22.843 −62.713 1.00 20.99 C ATOM 9298 C ALA C 196 −19.529 20.426 −62.107 1.00 21.99 C ATOM 9299 O ALA C 196 −18.483 20.076 −61.553 1.00 22.06 O ATOM 9300 N VAL C 197 −20.720 19.960 −61.761 1.00 21.96 N ATOM 9301 CA VAL C 197 −20.927 19.189 −60.562 1.00 21.08 C ATOM 9302 CB VAL C 197 −21.996 19.895 −59.724 1.00 20.64 C ATOM 9303 CG1 VAL C 197 −23.376 19.302 −59.981 1.00 20.66 C ATOM 9304 CG2 VAL C 197 −21.627 19.867 −58.258 1.00 20.68 C ATOM 9305 C VAL C 197 −21.331 17.740 −60.893 1.00 21.43 C ATOM 9306 O VAL C 197 −21.561 16.926 −59.986 1.00 21.30 O ATOM 9307 N GLN C 198 −21.389 17.431 −62.196 1.00 21.62 N ATOM 9308 CA GLN C 198 −21.889 16.153 −62.704 1.00 22.27 C ATOM 9309 CB GLN C 198 −22.066 16.191 −64.228 1.00 23.74 C ATOM 9310 CG GLN C 198 −22.623 14.893 −64.834 1.00 24.62 C ATOM 9311 CD GLN C 198 −24.145 14.787 −64.716 1.00 25.83 C ATOM 9312 OE1 GLN C 198 −24.880 15.663 −65.205 1.00 27.24 O ATOM 9313 NE2 GLN C 198 −24.627 13.721 −64.065 1.00 24.33 N ATOM 9314 C GLN C 198 −20.974 15.010 −62.374 1.00 22.08 C ATOM 9315 O GLN C 198 −19.788 15.045 −62.689 1.00 22.03 O ATOM 9316 N LEU C 199 −21.543 13.980 −61.765 1.00 22.36 N ATOM 9317 CA LEU C 199 −20.817 12.746 −61.507 1.00 23.03 C ATOM 9318 CB LEU C 199 −21.706 11.753 −60.746 1.00 22.68 C ATOM 9319 CG LEU C 199 −21.706 11.705 −59.208 1.00 22.15 C ATOM 9320 CD1 LEU C 199 −21.228 12.994 −58.554 1.00 20.88 C ATOM 9321 CD2 LEU C 199 −23.096 11.326 −58.711 1.00 21.73 C ATOM 9322 C LEU C 199 −20.358 12.139 −62.824 1.00 23.39 C ATOM 9323 O LEU C 199 −21.142 12.040 −63.764 1.00 23.49 O ATOM 9324 N GLU C 200 −19.083 11.759 −62.888 1.00 24.15 N ATOM 9325 CA GLU C 200 −18.523 11.071 −64.048 1.00 25.01 C ATOM 9326 CB GLU C 200 −17.073 10.675 −63.770 1.00 27.34 C ATOM 9327 CG GLU C 200 −16.042 11.632 −64.333 1.00 30.38 C ATOM 9328 CD GLU C 200 −14.933 11.959 −63.341 1.00 32.53 C ATOM 9329 OE1 GLU C 200 −15.130 12.882 −62.513 1.00 32.87 O ATOM 9330 OE2 GLU C 200 −13.858 11.308 −63.401 1.00 33.82 O ATOM 9331 C GLU C 200 −19.327 9.829 −64.444 1.00 24.25 C ATOM 9332 O GLU C 200 −19.522 9.565 −65.626 1.00 23.76 O ATOM 9333 N SER C 201 −19.788 9.070 −63.453 1.00 23.80 N ATOM 9334 CA SER C 201 −20.521 7.830 −63.711 1.00 24.17 C ATOM 9335 CB SER C 201 −20.784 7.086 −62.402 1.00 24.00 C ATOM 9336 OG SER C 201 −21.361 7.952 −61.444 1.00 24.53 O ATOM 9337 C SER C 201 −21.841 8.030 −64.491 1.00 24.32 C ATOM 9338 O SER C 201 −22.279 7.131 −65.234 1.00 24.55 O ATOM 9339 N LEU C 202 −22.456 9.204 −64.327 1.00 23.37 N ATOM 9340 CA LEU C 202 −23.756 9.491 −64.933 1.00 22.52 C ATOM 9341 CB LEU C 202 −24.641 10.294 −63.977 1.00 22.04 C ATOM 9342 CG LEU C 202 −24.808 9.908 −62.509 1.00 21.63 C ATOM 9343 CD1 LEU C 202 −25.641 10.967 −61.806 1.00 21.05 C ATOM 9344 CD2 LEU C 202 −25.444 8.536 −62.349 1.00 21.34 C ATOM 9345 C LEU C 202 −23.630 10.248 −66.241 1.00 22.37 C ATOM 9346 O LEU C 202 −24.631 10.587 −66.857 1.00 22.79 O ATOM 9347 N ASN C 203 −22.405 10.541 −66.650 1.00 22.67 N ATOM 9348 CA ASN C 203 −22.164 11.131 −67.960 1.00 23.88 C ATOM 9349 CB ASN C 203 −20.665 11.161 −68.257 1.00 22.53 C ATOM 9350 CG ASN C 203 −19.966 12.331 −67.615 1.00 21.37 C ATOM 9351 OD1 ASN C 203 −18.760 12.303 −67.405 1.00 20.80 O ATOM 9352 ND2 ASN C 203 −20.720 13.372 −67.307 1.00 21.55 N ATOM 9353 C ASN C 203 −22.898 10.375 −69.076 1.00 26.04 C ATOM 9354 O ASN C 203 −23.499 10.983 −69.972 1.00 26.30 O ATOM 9355 N LYS C 204 −22.859 9.044 −68.989 1.00 28.41 N ATOM 9356 CA LYS C 204 −23.413 8.153 −70.012 1.00 29.77 C ATOM 9357 CB LYS C 204 −23.100 6.693 −69.661 1.00 30.77 C ATOM 9358 CG LYS C 204 −21.631 6.434 −69.349 1.00 32.76 C ATOM 9359 CD LYS C 204 −21.333 4.961 −69.074 1.00 33.49 C ATOM 9360 CE LYS C 204 −21.648 4.559 −67.640 1.00 33.32 C ATOM 9361 NZ LYS C 204 −23.113 4.359 −67.458 1.00 34.55 N ATOM 9362 C LYS C 204 −24.921 8.338 −70.220 1.00 29.95 C ATOM 9363 O LYS C 204 −25.475 7.894 −71.223 1.00 30.63 O ATOM 9364 N CYS C 205 −25.579 9.000 −69.278 1.00 29.93 N ATOM 9365 CA CYS C 205 −27.025 9.137 −69.324 1.00 30.55 C ATOM 9366 CB CYS C 205 −27.628 8.771 −67.977 1.00 30.39 C ATOM 9367 SG CYS C 205 −26.915 7.269 −67.293 1.00 31.81 S ATOM 9368 C CYS C 205 −27.450 10.537 −69.705 1.00 31.15 C ATOM 9369 O CYS C 205 −28.651 10.833 −69.736 1.00 31.36 O ATOM 9370 N GLN C 206 −26.470 11.392 −70.001 1.00 31.36 N ATOM 9371 CA GLN C 206 −26.741 12.807 −70.222 1.00 31.39 C ATOM 9372 CB GLN C 206 −25.485 13.669 −70.034 1.00 31.08 C ATOM 9373 CG GLN C 206 −25.205 14.048 −68.577 1.00 32.12 C ATOM 9374 CD GLN C 206 −26.385 14.756 −67.886 1.00 33.35 C ATOM 9375 OE1 GLN C 206 −27.460 14.173 −67.714 1.00 34.34 O ATOM 9376 NE2 GLN C 206 −26.176 16.010 −67.468 1.00 32.07 N ATOM 9377 C GLN C 206 −27.438 13.068 −71.548 1.00 31.87 C ATOM 9378 O GLN C 206 −28.205 14.026 −71.669 1.00 32.96 O ATOM 9379 N ILE C 207 −27.196 12.199 −72.528 1.00 32.18 N ATOM 9380 CA ILE C 207 −27.991 12.199 −73.758 1.00 32.08 C ATOM 9381 CB ILE C 207 −27.202 11.651 −74.967 1.00 30.95 C ATOM 9382 CG1 ILE C 207 −26.096 12.641 −75.356 1.00 21.20 C ATOM 9383 CD1 ILE C 207 −24.981 12.048 −76.199 1.00 31.52 C ATOM 9384 CG2 ILE C 207 −28.126 11.417 −76.157 1.00 29.68 C ATOM 9385 C ILE C 207 −29.281 11.415 −73.542 1.00 32.22 C ATOM 9386 O ILE C 207 −29.255 10.321 −72.993 1.00 31.30 O ATOM 9387 N PHE C 208 −30.399 11.999 −73.969 1.00 34.27 N ATOM 9388 CA PHE C 208 −31.717 11.372 −73.855 1.00 36.28 C ATOM 9389 CB PHE C 208 −32.709 12.356 −73.233 1.00 38.45 C ATOM 9390 CG PHE C 208 −32.226 12.990 −71.966 1.00 41.26 C ATOM 9391 CD1 PHE C 208 −31.605 12.224 −70.971 1.00 42.83 C ATOM 9392 CE1 PHE C 208 −31.170 12.812 −69.785 1.00 44.02 C ATOM 9393 CZ PHE C 208 −31.365 14.173 −69.576 1.00 43.88 C ATOM 9394 CE2 PHE C 208 −31.994 14.942 −70.553 1.00 44.27 C ATOM 9395 CD2 PHE C 208 −32.421 14.350 −71.741 1.00 42.65 C ATOM 9396 C PHE C 208 −32.279 10.896 −75.204 1.00 36.09 C ATOM 9397 O PHE C 208 −31.917 11.430 −76.252 1.00 33.65 O ATOM 9398 N PRO C 209 −33.178 9.889 −75.175 1.00 37.08 N ATOM 9399 CA PRO C 209 −34.035 9.607 −76.328 1.00 38.05 C ATOM 9400 CB PRO C 209 −34.944 8.484 −75.823 1.00 37.29 C ATOM 9401 CG PRO C 209 −34.177 7.834 −74.731 1.00 37.21 C ATOM 9402 CD PRO C 209 −33.403 8.934 −74.073 1.00 37.17 C ATOM 9403 C PRO C 209 −34.875 10.841 −76.670 1.00 39.98 C ATOM 9404 O PRO C 209 −35.470 11.448 −75.771 1.00 41.36 O ATOM 9405 N SER C 210 −34.918 11.207 −77.949 1.00 40.34 N ATOM 9406 CA SER C 210 −35.511 12.478 −78.361 1.00 42.06 C ATOM 9407 CB SER C 210 −35.150 12.798 −79.810 1.00 42.46 C ATOM 9408 OG SER C 210 −35.202 11.632 −80.606 1.00 44.76 O ATOM 9409 C SER C 210 −37.023 12.559 −78.133 1.00 43.61 C ATOM 9410 O SER C 210 −37.715 11.546 −78.095 1.00 44.00 O ATOM 9411 N LYS C 211 −37.513 13.784 −77.969 1.00 47.83 N ATOM 9412 CA LYS C 211 −38.909 14.059 −77.605 1.00 51.30 C ATOM 9413 CB LYS C 211 −39.069 15.529 −77.150 1.00 51.58 C ATOM 9414 CG LYS C 211 −38.272 16.543 −77.974 1.00 51.85 C ATOM 9415 CD LYS C 211 −37.751 17.689 −77.112 1.00 53.24 C ATOM 9416 CE LYS C 211 −36.335 18.114 −77.510 1.00 52.78 C ATOM 9417 NZ LYS C 211 −35.724 19.108 −76.573 1.00 47.88 N ATOM 9418 C LYS C 211 −39.881 13.747 −78.741 1.00 53.32 C ATOM 9419 O LYS C 211 −39.659 14.186 −79.876 1.00 55.48 O ATOM 9420 N PRO C 212 −40.955 12.978 −78.444 1.00 54.57 N ATOM 9421 CA PRO C 212 −42.053 12.783 −79.407 1.00 55.36 C ATOM 9422 CB PRO C 212 −43.045 11.905 −78.635 1.00 55.16 C ATOM 9423 CG PRO C 212 −42.200 11.161 −77.657 1.00 54.18 C ATOM 9424 CD PRO C 212 −41.108 12.115 −77.255 1.00 54.02 C ATOM 9425 C PRO C 212 −42.704 14.113 −79.812 1.00 54.85 C ATOM 9426 O PRO C 212 −42.675 15.077 −79.039 1.00 54.21 O ATOM 9427 N VAL C 213 −43.278 14.160 −81.014 1.00 55.16 N ATOM 9428 CA VAL C 213 −43.784 15.421 −81.586 1.00 55.48 C ATOM 9429 CB VAL C 213 −43.693 15.445 −83.137 1.00 53.71 C ATOM 9430 CG1 VAL C 213 −42.283 15.809 −83.582 1.00 51.13 C ATOM 9431 CG2 VAL C 213 −44.136 14.115 −83.742 1.00 52.69 C ATOM 9432 C VAL C 213 −45.193 15.825 −81.112 1.00 56.11 C ATOM 9433 O VAL C 213 −46.142 15.038 −81.155 1.00 55.14 O ATOM 9434 N TYR C 221 −44.941 17.855 −70.831 1.00 59.00 N ATOM 9435 CA TYR C 221 −45.662 16.772 −70.167 1.00 59.89 C ATOM 9436 CB TYR C 221 −46.533 15.986 −71.168 1.00 64.56 C ATOM 9437 CG TYR C 221 −45.911 15.733 −72.534 1.00 67.38 C ATOM 9438 CD1 TYR C 221 −45.634 16.794 −73.413 1.00 66.88 C ATOM 9439 CE1 TYR C 221 −45.079 16.565 −74.662 1.00 67.09 C ATOM 9440 CZ TYR C 221 −44.814 15.259 −75.061 1.00 69.42 C ATOM 9441 OH TYR C 221 −44.268 15.027 −76.301 1.00 70.32 O ATOM 9442 CE2 TYR C 221 −45.092 14.189 −74.220 1.00 68.40 C ATOM 9443 CD2 TYR C 221 −45.642 14.429 −72.968 1.00 67.91 C ATOM 9444 C TYR C 221 −44.716 15.852 −69.378 1.00 58.43 C ATOM 9445 O TYR C 221 −43.841 16.342 −68.648 1.00 59.17 O ATOM 9446 N LYS C 222 −44.900 14.532 −69.512 1.00 53.69 N ATOM 9447 CA LYS C 222 −44.057 13.545 −68.813 1.00 47.25 C ATOM 9448 CB LYS C 222 −44.617 12.110 −68.910 1.00 45.93 C ATOM 9449 CG LYS C 222 −45.339 11.775 −70.209 1.00 49.11 C ATOM 9450 CD LYS C 222 −44.429 11.130 −71.248 1.00 49.94 C ATOM 9451 CE LYS C 222 −44.539 9.612 −71.231 1.00 49.87 C ATOM 9452 NZ LYS C 222 −43.450 8.988 −72.029 1.00 48.94 N ATOM 9453 C LYS C 222 −42.609 13.607 −69.283 1.00 44.03 C ATOM 9454 O LYS C 222 −41.689 13.523 −68.465 1.00 43.95 O ATOM 9455 N TRP C 223 −42.413 13.794 −70.590 1.00 39.58 N ATOM 9456 CA TRP C 223 −41.070 13.898 −71.161 1.00 34.76 C ATOM 9457 CB TRP C 223 −41.109 14.061 −72.679 1.00 33.31 C ATOM 9458 CG TRP C 223 −39.738 13.892 −73.290 1.00 33.47 C ATOM 9459 CD1 TRP C 223 −39.158 12.717 −73.773 1.00 33.76 C ATOM 9460 NE1 TRP C 223 −37.875 12.949 −74.220 1.00 33.13 N ATOM 9461 CE2 TRP C 223 −37.540 14.250 −74.056 1.00 32.70 C ATOM 9462 CD2 TRP C 223 −38.698 14.923 −73.449 1.00 33.19 C ATOM 9463 CE3 TRP C 223 −38.614 16.284 −73.161 1.00 32.27 C ATOM 9464 CZ3 TRP C 223 −37.429 16.955 −73.465 1.00 32.08 C ATOM 9465 CH2 TRP C 223 −36.337 16.292 −74.050 1.00 32.16 C ATOM 9466 CZ2 TRP C 223 −36.374 14.928 −74.356 1.00 32.22 C ATOM 9467 C TRP C 223 −40.266 15.003 −70.525 1.00 33.33 C ATOM 9468 O TRP C 223 −39.067 14.849 −70.302 1.00 32.25 O ATOM 9469 N TRP C 224 −40.917 16.124 −70.218 1.00 32.00 N ATOM 9470 CA TRP C 224 −40.240 17.248 −69.570 1.00 30.09 C ATOM 9471 CB TRP C 224 −40.963 18.566 −69.840 1.00 28.89 C ATOM 9472 CG TRP C 224 −40.704 19.028 −71.242 1.00 28.27 C ATOM 9473 CD1 TRP C 224 −41.482 18.787 −72.369 1.00 28.15 C ATOM 9474 NE1 TRP C 224 −40.898 19.330 −73.491 1.00 28.05 N ATOM 9475 CE2 TRP C 224 −39.722 19.916 −73.181 1.00 27.70 C ATOM 9476 CD2 TRP C 224 −39.527 19.751 −71.735 1.00 27.51 C ATOM 9477 CE3 TRP C 224 −38.382 20.265 −71.147 1.00 26.49 C ATOM 9478 CZ3 TRP C 224 −37.458 20.927 −71.960 1.00 26.25 C ATOM 9479 CH2 TRP C 224 −37.667 21.083 −73.342 1.00 26.32 C ATOM 9480 CZ2 TRP C 224 −38.799 20.577 −73.978 1.00 26.87 C ATOM 9481 C TRP C 224 −40.033 17.026 −68.109 1.00 29.90 C ATOM 9482 O TRP C 224 −39.049 17.503 −67.539 1.00 29.30 O ATOM 9483 N GLN C 225 −40.945 16.290 −67.483 1.00 30.10 N ATOM 9484 CA GLN C 225 −40.754 15.916 −66.094 1.00 30.63 C ATOM 9485 CB GLN C 225 −42.043 15.382 −65.483 1.00 34.32 C ATOM 9486 CG GLN C 225 −43.091 16.462 −65.225 1.00 39.23 C ATOM 9487 CD GLN C 225 −44.379 15.896 −64.646 1.00 42.45 C ATOM 9488 OE1 GLN C 225 −44.377 14.805 −64.054 1.00 44.71 O ATOM 9489 NE2 GLN C 225 −45.492 16.628 −64.817 1.00 41.85 N ATOM 9490 C GLN C 225 −39.639 14.894 −66.020 1.00 28.76 C ATOM 9491 O GLN C 225 −38.820 14.927 −65.097 1.00 28.26 O ATOM 9492 N LYS C 226 −39.596 14.014 −67.023 1.00 26.92 N ATOM 9493 CA LYS C 226 −38.505 13.060 −67.196 1.00 25.64 C ATOM 9494 CB LYS C 226 −38.824 12.094 −68.340 1.00 25.24 C ATOM 9495 C LYS C 226 −37.159 13.774 −67.432 1.00 24.58 C ATOM 9496 O LYS C 226 −36.182 13.539 −66.704 1.00 23.90 O ATOM 9497 N TYR C 227 −37.130 14.641 −68.446 1.00 23.65 N ATOM 9498 CA TYR C 227 −35.978 15.498 −68.760 1.00 22.85 C ATOM 9499 CB TYR C 227 −36.397 16.557 −69.780 1.00 23.05 C ATOM 9500 CG TYR C 227 −35.350 17.605 −70.113 1.00 22.92 C ATOM 9501 CD1 TYR C 227 −34.471 17.422 −71.176 1.00 23.07 C ATOM 9502 CE1 TYR C 227 −33.532 18.377 −71.501 1.00 22.62 C ATOM 9503 CZ TYR C 227 −33.465 19.541 −70.765 1.00 22.94 C ATOM 9504 OH TYR C 227 −32.520 20.485 −71.091 1.00 23.68 O ATOM 9505 CE2 TYR C 227 −34.329 19.761 −69.705 1.00 22.85 C ATOM 9506 CD2 TYR C 227 −35.272 18.799 −69.392 1.00 23.00 C ATOM 9507 C TYR C 227 −35.412 16.183 −67.516 1.00 22.51 C ATOM 9508 O TYR C 227 −34.200 16.130 −67.266 1.00 22.61 O ATOM 9509 N GLN C 228 −36.292 16.827 −66.748 1.00 21.29 N ATOM 9510 CA GLN C 228 −35.888 17.531 −65.539 1.00 20.54 C ATOM 9511 CB GLN C 228 −37.064 18.288 −64.912 1.00 19.85 C ATOM 9512 CG GLN C 228 −36.623 19.442 −64.019 1.00 19.47 C ATOM 9513 CD GLN C 228 −37.608 19.772 −62.913 1.00 19.25 C ATOM 9514 OE1 GLN C 228 −38.152 20.885 −62.858 1.00 18.74 O ATOM 9515 NE2 GLN C 228 −37.830 18.815 −62.009 1.00 19.20 N ATOM 9516 C GLN C 228 −35.257 16.597 −64.503 1.00 20.68 C ATOM 9517 O GLN C 228 −34.262 16.966 −63.874 1.00 20.83 O ATOM 9518 N ARG C 229 −35.835 15.400 −64.333 1.00 19.94 N ATOM 9519 CA ARG C 229 −35.366 14.450 −63.321 1.00 19.49 C ATOM 9520 CB ARG C 229 −36.360 13.291 −63.114 1.00 19.04 C ATOM 9521 C ARG C 229 −33.981 13.905 −63.649 1.00 19.38 C ATOM 9522 O ARG C 229 −33.166 13.702 −62.733 1.00 19.62 O ATOM 9523 N ARG C 230 −33.716 13.681 −64.942 1.00 18.55 N ATOM 9524 CA ARG C 230 −32.462 13.046 −65.374 1.00 18.27 C ATOM 9525 CB ARG C 230 −32.667 12.127 −66.589 1.00 17.93 C ATOM 9526 C ARG C 230 −31.332 14.044 −65.635 1.00 18.00 C ATOM 9527 O ARG C 230 −30.191 13.793 −65.260 1.00 18.43 O ATOM 9528 N LYS C 231 −31.644 15.168 −66.270 1.00 17.44 N ATOM 9529 CA LYS C 231 −30.624 16.174 −66.572 1.00 17.13 C ATOM 9530 CB LYS C 231 −31.167 17.209 −67.555 1.00 16.73 C ATOM 9531 CG LYS C 231 −30.385 18.504 −67.610 1.00 16.10 C ATOM 9532 CD LYS C 231 −30.494 19.057 −69.003 1.00 16.58 C ATOM 9533 CE LYS C 231 −29.450 20.108 −69.301 1.00 16.81 C ATOM 9534 NZ LYS C 231 −29.463 20.333 −70.771 1.00 16.80 N ATOM 9535 C LYS C 231 −30.088 16.862 −65.312 1.00 16.84 C ATOM 9536 O LYS C 231 −28.890 17.103 −65.189 1.00 17.01 O ATOM 9537 N PHE C 232 −30.981 17.164 −64.380 1.00 16.39 N ATOM 9538 CA PHE C 232 −30.620 17.920 −63.199 1.00 16.04 C ATOM 9539 CB PHE C 232 −31.635 19.018 −62.975 1.00 15.93 C ATOM 9540 CG PHE C 232 −31.623 20.042 −64.049 1.00 16.07 C ATOM 9541 CD1 PHE C 232 −30.554 20.916 −64.168 1.00 15.99 C ATOM 9542 CE1 PHE C 232 −30.523 21.862 −65.168 1.00 16.20 C ATOM 9543 CZ PHE C 232 −31.569 21.935 −66.077 1.00 16.59 C ATOM 9544 CE2 PHE C 232 −32.647 21.067 −65.972 1.00 16.48 C ATOM 9545 CD2 PHE C 232 −32.665 20.121 −64.959 1.00 16.27 C ATOM 9546 C PHE C 232 −30.491 17.056 −61.964 1.00 15.98 C ATOM 9547 O PHE C 232 −30.621 17.534 −60.843 1.00 16.07 O ATOM 9548 N HIS C 233 −30.214 15.780 −62.179 1.00 15.70 N ATOM 9549 CA HIS C 233 −30.095 14.840 −61.095 1.00 15.74 C ATOM 9550 CB HIS C 233 −29.733 13.477 −61.629 1.00 15.16 C ATOM 9551 CG HIS C 233 −29.676 12.432 −60.575 1.00 14.81 C ATOM 9552 ND1 HIS C 233 −28.529 11.911 −60.153 1.00 15.17 N ATOM 9553 CE1 HIS C 233 −28.778 11.006 −59.187 1.00 15.24 C ATOM 9554 NE2 HIS C 233 −30.097 10.969 −58.988 1.00 14.89 N ATOM 9555 CD2 HIS C 233 −30.682 11.837 −59.825 1.00 14.75 C ATOM 9556 C HIS C 233 −29.088 15.268 −60.067 1.00 16.45 C ATOM 9557 O HIS C 233 −29.369 15.259 −58.857 1.00 16.75 O ATOM 9558 N CYS C 234 −27.912 15.678 −60.533 1.00 17.12 N ATOM 9559 CA CYS C 234 −26.808 16.017 −59.639 1.00 17.27 C ATOM 9560 CB CYS C 234 −25.501 16.019 −60.410 1.00 18.17 C ATOM 9561 SG CYS C 234 −25.002 14.356 −60.882 1.00 19.89 S ATOM 9562 C CYS C 234 −26.979 17.329 −58.868 1.00 17.09 C ATOM 9563 O CYS C 234 −26.016 17.833 −58.281 1.00 17.38 O ATOM 9564 N ALA C 235 −28.199 17.874 −58.856 1.00 16.24 N ATOM 9565 CA ALA C 235 −28.517 18.993 −57.979 1.00 15.55 C ATOM 9566 CB ALA C 235 −29.946 19.449 −58.182 1.00 15.36 C ATOM 9567 C ALA C 235 −28.298 18.567 −56.536 1.00 15.51 C ATOM 9568 O ALA C 235 −27.913 19.375 −55.697 1.00 15.38 O ATOM 9569 N ASN C 236 −28.518 17.284 −56.260 1.00 15.24 N ATOM 9570 CA ASN C 236 −28.387 16.758 −54.919 1.00 15.04 C ATOM 9571 CB ASN C 236 −28.747 15.290 −54.907 1.00 16.24 C ATOM 9572 CG ASN C 236 −30.231 15.063 −55.141 1.00 17.51 C ATOM 9573 OD1 ASN C 236 −30.716 15.171 −56.277 1.00 17.96 O ATOM 9574 ND2 ASN C 236 −30.967 14.741 −54.064 1.00 17.56 N ATOM 9575 C ASN C 236 −27.019 16.963 −54.311 1.00 14.35 C ATOM 9576 O ASN C 236 −26.873 16.907 −53.088 1.00 13.84 O ATOM 9577 N LEU C 237 −26.038 17.226 −55.181 1.00 13.77 N ATOM 9578 CA LEU C 237 −24.639 17.470 −54.813 1.00 13.22 C ATOM 9579 CB LEU C 237 −23.739 17.143 −56.003 1.00 13.30 C ATOM 9580 CG LEU C 237 −23.536 15.682 −56.428 1.00 13.70 C ATOM 9581 CD1 LEU C 237 −22.236 15.115 −55.884 1.00 13.92 C ATOM 9582 CD2 LEU C 237 −24.695 14.779 −56.028 1.00 13.79 C ATOM 9583 C LEU C 237 −24.440 18.928 −54.424 1.00 12.92 C ATOM 9584 O LEU C 237 −23.435 19.306 −53.811 1.00 12.49 O ATOM 9585 N THR C 238 −25.421 19.742 −54.799 1.00 12.76 N ATOM 9586 CA THR C 238 −25.362 21.176 −54.644 1.00 12.24 C ATOM 9587 CB THR C 238 −25.613 21.886 −56.000 1.00 12.07 C ATOM 9588 OG1 THR C 238 −27.015 22.071 −56.220 1.00 11.66 O ATOM 9589 CG2 THR C 238 −25.037 21.079 −57.163 1.00 11.99 C ATOM 9590 C THR C 238 −26.401 21.577 −53.618 1.00 12.19 C ATOM 9591 O THR C 238 −27.017 20.740 −52.988 1.00 11.84 O ATOM 9592 N SER C 239 −26.616 22.867 −53.468 1.00 12.91 N ATOM 9593 CA SER C 239 −27.517 23.362 −52.442 1.00 13.54 C ATOM 9594 CB SER C 239 −26.807 24.431 −51.608 1.00 13.54 C ATOM 9595 OG SER C 239 −26.062 25.269 −52.467 1.00 13.80 O ATOM 9596 C SER C 239 −28.846 23.892 −53.000 1.00 13.78 C ATOM 9597 O SER C 239 −29.552 24.631 −52.314 1.00 14.37 O ATOM 9598 N TRP C 240 −29.197 23.504 −54.222 1.00 13.87 N ATOM 9599 CA TRP C 240 −30.508 23.847 −54.776 1.00 14.36 C ATOM 9600 CB TRP C 240 −30.435 25.135 −55.600 1.00 14.43 C ATOM 9601 CG TRP C 240 −30.622 26.315 −54.689 1.00 14.97 C ATOM 9602 CD1 TRP C 240 −31.744 26.625 −53.897 1.00 15.12 C ATOM 9603 NE1 TRP C 240 −31.523 27.754 −53.136 1.00 14.78 N ATOM 9604 CE2 TRP C 240 −30.296 28.226 −53.358 1.00 14.80 C ATOM 9605 CD2 TRP C 240 −29.645 27.329 −54.358 1.00 15.07 C ATOM 9606 CE3 TRP C 240 −28.354 27.592 −54.762 1.00 15.05 C ATOM 9607 CZ3 TRP C 240 −27.714 28.694 −54.210 1.00 15.22 C ATOM 9608 CH2 TRP C 240 −28.357 29.538 −53.272 1.00 15.30 C ATOM 9609 CZ2 TRP C 240 −29.662 29.311 −52.834 1.00 14.82 C ATOM 9610 C TRP C 240 −31.270 22.725 −55.473 1.00 14.75 C ATOM 9611 O TRP C 240 −30.704 21.673 −55.790 1.00 14.98 O ATOM 9612 N PRO C 241 −32.577 22.928 −55.704 1.00 14.83 N ATOM 9613 CA PRO C 241 −33.408 21.896 −56.289 1.00 15.37 C ATOM 9614 CB PRO C 241 −34.823 22.336 −55.900 1.00 15.45 C ATOM 9615 CG PRO C 241 −34.677 23.547 −55.042 1.00 15.05 C ATOM 9616 CD PRO C 241 −33.363 24.124 −55.395 1.00 14.77 C ATOM 9617 C PRO C 241 −33.315 21.825 −57.816 1.00 15.97 C ATOM 9618 O PRO C 241 −32.891 22.794 −58.458 1.00 16.18 O ATOM 9619 N ARG C 242 −33.738 20.684 −58.376 1.00 16.47 N ATOM 9620 CA ARG C 242 −33.867 20.484 −59.831 1.00 16.39 C ATOM 9621 CB ARG C 242 −34.557 19.145 −60.129 1.00 17.50 C ATOM 9622 CG ARG C 242 −33.621 17.945 −60.005 1.00 19.59 C ATOM 9623 CD ARG C 242 −34.281 16.589 −60.293 1.00 20.79 C ATOM 9624 NE ARG C 242 −34.739 15.950 −59.064 1.00 21.38 N ATOM 9625 CZ ARG C 242 −36.010 15.910 −58.666 1.00 22.16 C ATOM 9626 NH1 ARG C 242 −36.974 16.454 −59.422 1.00 21.68 N ATOM 9627 NH2 ARG C 242 −36.318 15.314 −57.508 1.00 22.31 N ATOM 9628 C ARG C 242 −34.626 21.613 −60.518 1.00 15.80 C ATOM 9629 O ARG C 242 −34.194 22.107 −61.556 1.00 15.63 O ATOM 9630 N TRP C 243 −35.747 22.027 −59.920 1.00 15.28 N ATOM 9631 CA TRP C 243 −36.653 23.014 −60.523 1.00 14.41 C ATOM 9632 CB TRP C 243 −38.016 23.022 −59.830 1.00 14.04 C ATOM 9633 CG TRP C 243 −37.972 23.197 −58.327 1.00 13.76 C ATOM 9634 CD1 TRP C 243 −37.986 22.194 −57.358 1.00 13.71 C ATOM 9635 NE1 TRP C 243 −37.949 22.729 −56.090 1.00 13.52 N ATOM 9636 CE2 TRP C 243 −37.914 24.079 −56.142 1.00 13.61 C ATOM 9637 CD2 TRP C 243 −37.935 24.457 −57.570 1.00 13.56 C ATOM 9638 CE3 TRP C 243 −37.898 25.802 −57.910 1.00 13.33 C ATOM 9639 CZ3 TRP C 243 −37.848 26.751 −56.872 1.00 13.50 C ATOM 9640 CH2 TRP C 243 −37.840 26.368 −55.508 1.00 13.27 C ATOM 9641 CZ2 TRP C 243 −37.868 25.030 −55.121 1.00 13.27 C ATOM 9642 C TRP C 243 −36.086 24.400 −60.577 1.00 14.17 C ATOM 9643 O TRP C 243 −36.615 25.261 −61.283 1.00 14.00 O ATOM 9644 N LEU C 244 −35.008 24.639 −59.835 1.00 14.04 N ATOM 9645 CA LEU C 244 −34.320 25.929 −59.911 1.00 13.86 C ATOM 9646 CB LEU C 244 −33.543 26.226 −58.635 1.00 13.41 C ATOM 9647 CG LEU C 244 −32.777 27.524 −58.799 1.00 13.43 C ATOM 9648 CD1 LEU C 244 −33.691 28.732 −58.656 1.00 13.62 C ATOM 9649 CD2 LEU C 244 −31.649 27.576 −57.799 1.00 13.99 C ATOM 9650 C LEU C 244 −33.375 25.936 −61.100 1.00 13.72 C ATOM 9651 O LEU C 244 −33.461 26.784 −61.998 1.00 13.30 O ATOM 9652 N TYR C 245 −32.470 24.969 −61.098 1.00 13.66 N ATOM 9653 CA TYR C 245 −31.561 24.807 −62.194 1.00 13.81 C ATOM 9654 CB TYR C 245 −30.733 23.549 −61.974 1.00 13.45 C ATOM 9655 CG TYR C 245 −29.740 23.687 −60.833 1.00 13.26 C ATOM 9656 CD1 TYR C 245 −28.661 24.570 −60.926 1.00 13.35 C ATOM 9657 CE1 TYR C 245 −27.745 24.708 −59.894 1.00 13.08 C ATOM 9658 CZ TYR C 245 −27.894 23.951 −58.741 1.00 13.02 C ATOM 9659 OH TYR C 245 −26.979 24.089 −57.720 1.00 12.49 O ATOM 9660 CE2 TYR C 245 −28.962 23.068 −58.618 1.00 13.05 C ATOM 9661 CD2 TYR C 245 −29.876 22.941 −59.662 1.00 13.18 C ATOM 9662 C TYR C 245 −32.349 24.788 −63.517 1.00 14.28 C ATOM 9663 O TYR C 245 −31.842 25.184 −64.587 1.00 14.77 O ATOM 9664 N SER C 246 −33.610 24.377 −63.418 1.00 14.31 N ATOM 9665 CA SER C 246 −34.500 24.298 −64.559 1.00 14.22 C ATOM 9666 CB SER C 246 −35.797 23.587 −64.173 1.00 13.89 C ATOM 9667 OG SER C 246 −36.412 23.020 −65.307 1.00 13.72 O ATOM 9668 C SER C 246 −34.787 25.685 −65.099 1.00 14.49 C ATOM 9669 O SER C 246 −34.832 25.877 −66.310 1.00 15.32 O ATOM 9670 N LEU C 247 −34.945 26.656 −64.199 1.00 14.48 N ATOM 9671 CA LEU C 247 −35.226 28.050 −64.577 1.00 14.24 C ATOM 9672 CB LEU C 247 −35.737 28.833 −63.366 1.00 13.64 C ATOM 9673 CG LEU C 247 −37.092 28.452 −62.796 1.00 13.35 C ATOM 9674 CD1 LEU C 247 −37.291 29.071 −61.423 1.00 13.05 C ATOM 9675 CD2 LEU C 247 −38.197 28.878 −63.750 1.00 13.39 C ATOM 9676 C LEU C 247 −34.026 28.787 −65.211 1.00 14.53 C ATOM 9677 O LEU C 247 −34.141 29.952 −65.559 1.00 14.26 O ATOM 9678 N TYR C 248 −32.880 28.112 −65.337 1.00 15.31 N ATOM 9679 CA TYR C 248 −31.717 28.659 −66.068 1.00 15.94 C ATOM 9680 CB TYR C 248 −30.542 28.940 −65.121 1.00 15.63 C ATOM 9681 CG TYR C 248 −30.849 29.992 −64.083 1.00 15.54 C ATOM 9682 CD1 TYR C 248 −31.443 29.638 −62.863 1.00 15.64 C ATOM 9683 CE1 TYR C 248 −31.741 30.597 −61.904 1.00 15.61 C ATOM 9684 CZ TYR C 248 −31.452 31.933 −62.164 1.00 15.76 C ATOM 9685 OH TYR C 248 −31.752 32.875 −61.205 1.00 16.10 O ATOM 9686 CE2 TYR C 248 −30.872 32.315 −63.377 1.00 15.49 C ATOM 9687 CD2 TYR C 248 −30.572 31.345 −64.324 1.00 15.32 C ATOM 9688 C TYR C 248 −31.267 27.776 −67.235 1.00 16.39 C ATOM 9689 O TYR C 248 −30.182 27.967 −67.776 1.00 16.44 O ATOM 9690 N ASP C 249 −32.126 26.834 −67.623 1.00 17.22 N ATOM 9691 CA ASP C 249 −31.821 25.829 −68.636 1.00 17.95 C ATOM 9692 CB ASP C 249 −32.470 24.484 −68.251 1.00 18.52 C ATOM 9693 CG ASP C 249 −32.268 23.385 −69.313 1.00 19.28 C ATOM 9694 OD1 ASP C 249 −31.108 23.000 −69.608 1.00 19.43 O ATOM 9695 OD2 ASP C 249 −33.288 22.883 −69.840 1.00 19.76 O ATOM 9696 C ASP C 249 −32.323 26.302 −69.989 1.00 18.51 C ATOM 9697 O ASP C 249 −33.539 26.350 −70.236 1.00 18.94 O ATOM 9698 N ALA C 250 −31.381 26.646 −70.867 1.00 18.92 N ATOM 9699 CA ALA C 250 −31.695 27.197 −72.191 1.00 18.61 C ATOM 9700 CB ALA C 250 −30.439 27.345 −73.021 1.00 18.15 C ATOM 9701 C ALA C 250 −32.723 26.371 −72.934 1.00 18.91 C ATOM 9702 O ALA C 250 −33.625 26.911 −73.544 1.00 19.22 O ATOM 9703 N GLU C 251 −32.597 25.056 −72.861 1.00 19.84 N ATOM 9704 CA GLU C 251 −33.498 24.183 −73.589 1.00 20.75 C ATOM 9705 CB GLU C 251 −33.020 22.724 −73.521 1.00 23.28 C ATOM 9706 CG GLU C 251 −31.496 22.564 −73.421 1.00 27.05 C ATOM 9707 CD GLU C 251 −30.774 22.680 −74.769 1.00 31.07 C ATOM 9708 OE1 GLU C 251 −30.755 21.684 −75.532 1.00 32.67 O ATOM 9709 OE2 GLU C 251 −30.197 23.760 −75.065 1.00 33.25 O ATOM 9710 C GLU C 251 −34.931 24.365 −73.069 1.00 19.50 C ATOM 9711 O GLU C 251 −35.874 24.484 −73.856 1.00 19.11 O ATOM 9712 N THR C 252 −35.085 24.444 −71.749 1.00 18.54 N ATOM 9713 CA THR C 252 −36.422 24.604 −71.144 1.00 17.88 C ATOM 9714 CB THR C 252 −36.409 24.460 −69.603 1.00 17.24 C ATOM 9715 OG1 THR C 252 −35.565 23.375 −69.227 1.00 17.52 O ATOM 9716 CG2 THR C 252 −37.797 24.190 −69.088 1.00 16.72 C ATOM 9717 C THR C 252 −37.046 24.946 −71.511 1.00 17.19 C ATOM 9718 O THR C 252 −38.150 25.995 −72.044 1.00 16.64 O ATOM 9719 N LEU C 253 −36.316 27.017 −71.220 1.00 16.69 N ATOM 9720 CA LEU C 253 −36.774 28.366 −71.440 1.00 16.60 C ATOM 9721 CB LEU C 253 −35.640 29.334 −71.124 1.00 16.32 C ATOM 9722 CG LEU C 253 −36.300 29.533 −69.646 1.00 16.12 C ATOM 9723 CD1 LEU C 253 −33.814 29.765 −69.482 1.00 15.93 C ATOM 9724 CD2 LEU C 253 −36.100 30.666 −69.028 1.00 15.72 C ATOM 9725 C LEU C 253 −37.243 28.542 −72.877 1.00 17.32 C ATOM 9726 O LEU C 253 −38.340 29.048 −73.124 1.00 17.03 O ATOM 9727 N MET C 254 −36.410 28.092 −73.819 1.00 18.59 N ATOM 9728 CA MET C 254 −36.699 28.163 −75.255 1.00 19.27 C ATOM 9729 CB MET C 254 −35.587 27.480 −76.067 1.00 19.24 C ATOM 9730 CG MET C 254 −34.286 28.272 −76.206 1.00 19.30 C ATOM 9731 SD MET C 254 −33.130 27.598 −77.442 1.00 19.82 S ATOM 9732 CE MET C 254 −32.451 26.173 −76.599 1.00 19.99 C ATOM 9733 C MET C 254 −38.057 27.526 −75.563 1.00 20.03 C ATOM 9734 O MET C 254 −38.853 28.077 −76.328 1.00 19.99 O ATOM 9735 N ASP C 255 −38.311 26.378 −74.938 1.00 21.37 N ATOM 9736 CA ASP C 255 −39.577 25.662 −75.062 1.00 22.36 C ATOM 9737 CB ASP C 255 −39.485 24.311 −74.359 1.00 23.47 C ATOM 9738 CG ASP C 255 −40.677 23.430 −74.648 1.00 24.95 C ATOM 9739 OD1 ASP C 255 −40.781 22.920 −75.788 1.00 25.85 O ATOM 9740 OD2 ASP C 255 −41.512 23.249 −73.735 1.00 26.09 O ATOM 9741 C ASP C 255 −40.759 26.457 −74.505 1.00 22.49 C ATOM 9742 O ASP C 255 −41.803 26.562 −75.150 1.00 23.31 O ATOM 9743 N ARG C 256 −40.594 27.015 −73.312 1.00 22.59 N ATOM 9744 CA ARG C 256 −41.629 27.856 −72.707 1.00 22.81 C ATOM 9745 CB ARG C 256 −41.210 28.310 −71.300 1.00 21.46 C ATOM 9746 CG ARG C 256 −41.274 27.216 −70.241 1.00 20.00 C ATOM 9747 CD ARG C 256 −40.560 27.616 −68.968 1.00 19.62 C ATOM 9748 NE ARG C 256 −41.235 28.712 −68.276 1.00 19.78 N ATOM 9749 CZ ARG C 256 −40.641 29.564 −67.442 1.00 19.72 C ATOM 9750 NH1 ARG C 256 −39.338 29.471 −67.189 1.00 19.89 N ATOM 9751 NH2 ARG C 256 −41.347 30.532 −66.880 1.00 19.30 N ATOM 9752 C ARG C 256 −41.947 29.059 −73.598 1.00 24.00 C ATOM 9753 O ARG C 256 −43.108 29.470 −73.709 1.00 24.22 O ATOM 9754 N ILE C 257 −40.912 29.607 −74.238 1.00 25.25 N ATOM 9755 CA ILE C 257 −41.085 30.713 −75.182 1.00 26.82 C ATOM 9756 CB ILE C 257 −39.745 31.427 −75.515 1.00 26.81 C ATOM 9757 CG1 ILE C 257 −39.202 32.161 −74.284 1.00 26.51 C ATOM 9758 CD1 ILE C 257 −37.727 32.502 −74.373 1.00 26.76 C ATOM 9759 CG2 ILE C 257 −39.916 32.440 −76.637 1.00 26.25 C ATOM 9760 C ILE C 257 −41.792 30.232 −76.448 1.00 27.92 C ATOM 9761 O ILE C 257 −42.727 30.875 −76.909 1.00 28.42 O ATOM 9762 N LYS C 258 −41.363 29.089 −76.987 1.00 29.78 N ATOM 9763 CA LYS C 258 −42.007 28.504 −78.175 1.00 31.23 C ATOM 9764 CB LYS C 258 −41.534 27.073 −78.435 1.00 32.04 C ATOM 9765 CG LYS C 258 −40.271 26.986 −79.273 1.00 34.19 C ATOM 9766 CD LYS C 258 −39.868 25.541 −79.530 1.00 35.74 C ATOM 9767 CE LYS C 258 −38.447 25.462 −80.076 1.00 37.80 C ATOM 9768 NZ LYS C 258 −38.015 24.063 −80.362 1.00 37.95 N ATOM 9769 C LYS C 258 −43.522 28.529 −78.072 1.00 31.54 C ATOM 9770 O LYS C 258 −44.201 29.025 −78.975 1.00 32.23 O ATOM 9771 N LYS C 259 −44.045 28.018 −76.960 1.00 30.87 N ATOM 9772 CA LYS C 259 −45.492 27.925 −76.760 1.00 31.43 C ATOM 9773 CB LYS C 259 −45.806 27.233 −75.430 1.00 30.41 C ATOM 9774 CG LYS C 259 −45.522 25.745 −75.505 1.00 30.13 C ATOM 9775 CD LYS C 259 −45.284 25.114 −74.152 1.00 29.96 C ATOM 9776 CE LYS C 259 −44.817 23.679 −74.330 1.00 29.65 C ATOM 9777 NZ LYS C 259 −45.363 22.796 −73.266 1.00 29.97 N ATOM 9778 C LYS C 259 −46.239 29.259 −76.912 1.00 32.03 C ATOM 9779 O LYS C 259 −47.315 29.305 −77.509 1.00 32.66 O ATOM 9780 N GLN C 260 −45.659 30.339 −76.398 1.00 32.93 N ATOM 9781 CA GLN C 260 −46.230 31.669 −76.594 1.00 33.87 C ATOM 9782 CB GLN C 260 −45.521 32.717 −75.723 1.00 35.69 C ATOM 9783 CG GLN C 260 −45.012 32.211 −74.375 1.00 36.79 C ATOM 9784 CD GLN C 260 −45.875 32.641 −73.200 1.00 37.13 C ATOM 9785 OE1 GLN C 260 −45.495 33.524 −72.423 1.00 36.68 O ATOM 9786 NE2 GLN C 260 −47.038 32.017 −73.061 1.00 37.51 N ATOM 9787 C GLN C 260 −46.135 32.050 −78.073 1.00 32.94 C ATOM 9788 O GLN C 260 −47.116 32.455 −78.672 1.00 33.48 O ATOM 9789 N LEU C 261 −44.953 31.882 −78.658 1.00 33.21 N ATOM 9790 CA LEU C 261 −44.726 32.185 −80.074 1.00 34.64 C ATOM 9791 CB LEU C 261 −43.258 31.939 −80.446 1.00 33.70 C ATOM 9792 CG LEU C 261 −42.121 32.765 −79.842 1.00 32.36 C ATOM 9793 CD1 LEU C 261 −40.802 32.215 −80.334 1.00 32.19 C ATOM 9794 CD2 LEU C 261 −42.229 34.229 −80.222 1.00 32.93 C ATOM 9795 C LEU C 261 −45.633 31.368 −81.007 1.00 36.22 C ATOM 9796 O LEU C 261 −45.859 31.751 −82.161 1.00 35.31 O ATOM 9797 N ARG C 262 −46.130 30.243 −80.490 1.00 38.64 N ATOM 9798 CA ARG C 262 −47.024 29.337 −81.209 1.00 41.28 C ATOM 9799 CB ARG C 262 −47.115 28.000 −80.460 1.00 44.98 C ATOM 9800 CG ARG C 262 −47.739 26.837 −81.230 1.00 46.98 C ATOM 9801 CD ARG C 262 −47.233 25.483 −80.723 1.00 48.56 C ATOM 9802 NE ARG C 262 −45.783 25.478 −80.476 1.00 51.46 N ATOM 9803 CZ ARG C 262 −44.841 25.459 −81.425 1.00 52.29 C ATOM 9804 NH1 ARG C 262 −45.174 25.437 −82.712 1.00 52.70 N ATOM 9805 NH2 ARG C 262 −43.557 25.465 −81.085 1.00 51.44 N ATOM 9806 C ARG C 262 −48.411 29.942 −81.344 1.00 42.20 C ATOM 9807 O ARG C 262 −49.129 29.646 −82.303 1.00 43.35 O ATOM 9808 N GLU C 263 −48.790 30.787 −80.386 1.00 44.06 N ATOM 9809 CA GLU C 263 −50.077 31.477 −80.447 1.00 47.87 C ATOM 9810 CB GLU C 263 −50.515 31.940 −79.049 1.00 51.09 C ATOM 9811 CG GLU C 263 −50.085 33.349 −78.671 1.00 57.28 C ATOM 9812 CD GLU C 263 −49.610 33.457 −77.232 1.00 64.07 C ATOM 9813 OE1 GLU C 263 −50.136 32.711 −76.369 1.00 68.03 O ATOM 9814 OE2 GLU C 263 −48.701 34.285 −76.969 1.00 63.80 O ATOM 9815 C GLU C 263 −50.073 32.627 −81.485 1.00 47.88 C ATOM 9816 O GLU C 263 −51.080 33.311 −81.680 1.00 48.06 O ATOM 9817 N TRP C 264 −48.929 32.817 −82.146 1.00 49.24 N ATOM 9818 CA TRP C 264 −48.797 33.751 −83.274 1.00 48.11 C ATOM 9819 CB TRP C 264 −47.637 34.729 −83.037 1.00 46.73 C ATOM 9820 CG TRP C 264 −47.756 35.484 −81.715 1.00 46.62 C ATOM 9821 CD1 TRP C 264 −48.915 35.706 −80.964 1.00 47.65 C ATOM 9822 NE1 TRP C 264 −48.641 36.433 −79.826 1.00 45.58 N ATOM 9823 CE2 TRP C 264 −47.336 36.748 −79.765 1.00 44.69 C ATOM 9824 CD2 TRP C 264 −46.690 36.168 −80.957 1.00 45.87 C ATOM 9825 CE3 TRP C 264 −45.319 36.346 −81.133 1.00 46.07 C ATOM 9826 CZ3 TRP C 264 −44.608 37.076 −80.161 1.00 44.78 C ATOM 9827 CH2 TRP C 264 −45.246 37.618 −79.031 1.00 44.28 C ATOM 9828 CZ2 TRP C 264 −46.623 37.464 −78.814 1.00 44.82 C ATOM 9829 C TRP C 264 −48.702 33.025 −84.611 1.00 49.12 C ATOM 9830 O TRP C 264 −48.659 33.662 −85.665 1.00 47.87 O ATOM 9831 N ASP C 265 −48.661 31.681 −84.559 1.00 50.74 N ATOM 9832 CA ASP C 265 −49.059 30.797 −85.681 1.00 49.67 C ATOM 9833 CB ASP C 265 −48.275 29.467 −85.680 1.00 48.64 C ATOM 9834 CG ASP C 265 −48.916 28.381 −86.605 1.00 49.22 C ATOM 9835 OD1 ASP C 265 −48.708 28.434 −87.846 1.00 46.85 O ATOM 9836 OD2 ASP C 265 −49.616 27.472 −86.085 1.00 45.67 O ATOM 9837 C ASP C 265 −50.554 30.491 −85.564 1.00 49.03 C ATOM 9838 O ASP C 265 −51.273 30.445 −86.563 1.00 47.68 O ATOM 9839 N SER C 272 −38.088 24.850 −88.261 1.00 40.77 N ATOM 9840 CA SER C 272 −38.825 25.753 −87.381 1.00 41.58 C ATOM 9841 CB SER C 272 −39.150 25.056 −86.044 1.00 41.18 C ATOM 9842 OG SER C 272 −40.444 24.475 −86.058 1.00 39.55 O ATOM 9843 C SER C 272 −38.092 27.095 −87.156 1.00 41.72 C ATOM 9844 O SER C 272 −38.293 28.049 −87.912 1.00 42.23 O ATOM 9845 N LEU C 273 −37.259 27.151 −86.107 1.00 39.80 N ATOM 9846 CA LEU C 273 −36.482 28.352 −85.717 1.00 36.44 C ATOM 9847 CB LEU C 273 −37.188 29.151 −84.597 1.00 35.60 C ATOM 9848 CG LEU C 273 −38.664 28.934 −84.237 1.00 34.87 C ATOM 9849 CD1 LEU C 273 −38.810 27.805 −83.218 1.00 34.17 C ATOM 9850 CD2 LEU C 273 −39.264 30.220 −83.697 1.00 34.18 C ATOM 9851 C LEU C 273 −35.087 27.890 −85.248 1.00 34.15 C ATOM 9852 O LEU C 273 −34.795 26.694 −85.280 1.00 33.39 O ATOM 9853 N PRO C 274 −34.218 28.823 −84.811 1.00 32.84 N ATOM 9854 CA PRO C 274 −32.879 28.353 −84.450 1.00 32.66 C ATOM 9855 CB PRO C 274 −32.121 29.646 −84.129 1.00 32.26 C ATOM 9856 CG PRO C 274 −32.931 30.753 −84.728 1.00 31.84 C ATOM 9857 CD PRO C 274 −34.348 30.284 −84.655 1.00 32.75 C ATOM 9858 C PRO C 274 −32.884 27.417 −83.234 1.00 33.21 C ATOM 9859 O PRO C 274 −33.785 27.492 −82.385 1.00 32.41 O ATOM 9860 N SER C 275 −31.891 26.528 −83.178 1.00 33.75 N ATOM 9861 CA SER C 275 −31.737 25.572 −82.075 1.00 32.87 C ATOM 9862 CB SER C 275 −31.299 24.203 −82.598 1.00 33.74 C ATOM 9863 OG SER C 275 −32.142 23.765 −83.653 1.00 35.23 O ATOM 9864 C SER C 275 −30.713 26.093 −81.080 1.00 31.88 C ATOM 9865 O SER C 275 −30.799 25.805 −79.881 1.00 32.38 O ATOM 9866 N ASN C 276 −29.744 26.850 −81.597 1.00 30.05 N ATOM 9867 CA ASN C 276 −28.781 27.569 −80.782 1.00 29.46 C ATOM 9868 CB ASN C 276 −27.686 28.172 −81.664 1.00 30.73 C ATOM 9869 CG ASN C 276 −26.553 28.789 −80.858 1.00 31.97 C ATOM 9870 OD1 ASN C 276 −26.780 29.553 −79.919 1.00 32.94 O ATOM 9871 ND2 ASN C 276 −25.319 28.458 −81.227 1.00 32.30 N ATOM 9872 C ASN C 276 −29.467 28.677 −79.993 1.00 29.22 C ATOM 9873 O ASN C 276 −30.107 29.563 −80.584 1.00 29.70 O ATOM 9874 N PRO C 277 −29.327 28.639 −78.653 1.00 27.66 N ATOM 9875 CA PRO C 277 −29.951 29.615 −77.748 1.00 26.72 C ATOM 9876 CB PRO C 277 −29.406 29.220 −76.366 1.00 26.44 C ATOM 9877 CG PRO C 277 −29.009 27.797 −76.512 1.00 26.49 C ATOM 9878 CD PRO C 277 −28.538 27.635 −77.923 1.00 26.78 C ATOM 9879 C PRO C 277 −29.603 31.075 −78.072 1.00 25.35 C ATOM 9880 O PRO C 277 −30.472 31.933 −77.972 1.00 24.83 O ATOM 9881 N ILE C 278 −28.351 31.345 −78.444 1.00 24.57 N ATOM 9882 CA ILE C 278 −27.930 32.694 −78.846 1.00 25.01 C ATOM 9883 CB ILE C 278 −26.464 32.724 −79.342 1.00 24.99 C ATOM 9884 CG1 ILE C 278 −25.498 32.298 −78.238 1.00 24.76 C ATOM 9885 CD1 ILE C 278 −24.143 31.872 −78.760 1.00 24.60 C ATOM 9886 CG2 ILE C 278 −26.098 34.108 −79.859 1.00 25.15 C ATOM 9887 C ILE C 278 −28.829 33.242 −79.959 1.00 25.04 C ATOM 9888 O ILE C 278 −29.382 34.333 −79.844 1.00 24.34 O ATOM 9889 N ASP C 279 −28.976 32.471 −81.031 1.00 25.63 N ATOM 9890 CA ASP C 279 −29.787 32.892 −82.160 1.00 26.77 C ATOM 9891 CB ASP C 279 −29.721 31.851 −83.269 1.00 27.30 C ATOM 9892 CG ASP C 279 −28.349 31.736 −83.871 1.00 28.23 C ATOM 9893 OD1 ASP C 279 −27.719 32.791 −84.147 1.00 28.37 O ATOM 9894 OD2 ASP C 279 −27.904 30.588 −84.076 1.00 28.99 O ATOM 9895 C ASP C 279 −31.229 33.105 −81.737 1.00 26.45 C ATOM 9896 O ASP C 279 −31.829 34.145 −81.997 1.00 26.30 O ATOM 9897 N PHE C 280 −31.768 32.100 −81.070 1.00 27.14 N ATOM 9898 CA PHE C 280 −33.154 32.093 −80.663 1.00 26.89 C ATOM 9899 CB PHE C 280 −33.428 30.839 −79.835 1.00 27.45 C ATOM 9900 CG PHE C 280 −34.869 30.623 −79.524 1.00 28.05 C ATOM 9901 CD1 PHE C 280 −35.472 31.289 −78.460 1.00 27.72 C ATOM 9902 CE1 PHE C 280 −36.810 31.084 −78.167 1.00 27.94 C ATOM 9903 CZ PHE C 280 −37.562 30.204 −78.934 1.00 28.04 C ATOM 9904 CE2 PHE C 280 −36.973 29.532 −79.993 1.00 28.81 C ATOM 9905 CD2 PHE C 280 −35.631 29.740 −80.285 1.00 28.63 C ATOM 9906 C PHE C 280 −33.461 33.344 −79.864 1.00 26.11 C ATOM 9907 O PHE C 280 −34.428 34.032 −80.146 1.00 26.03 O ATOM 9908 N SER C 281 −32.602 33.646 −78.892 1.00 26.07 N ATOM 9909 CA SER C 281 −32.819 34.754 −77.962 1.00 25.48 C ATOM 9910 CB SER C 281 −31.774 34.734 −76.850 1.00 25.03 C ATOM 9911 OG SER C 281 −30.494 35.048 −77.360 1.00 24.63 O ATOM 9912 C SER C 281 −32.805 36.096 −78.666 1.00 24.70 C ATOM 9913 O SER C 281 −33.548 36.996 −78.296 1.00 24.25 O ATOM 9914 N TYR C 282 −31.964 36.210 −79.689 1.00 25.19 N ATOM 9915 CA TYR C 282 −31.899 37.410 −80.543 1.00 26.07 C ATOM 9916 CB TYR C 282 −30.561 37.464 −81.288 1.00 24.52 C ATOM 9917 CG TYR C 282 −29.406 37.882 −80.422 1.00 24.02 C ATOM 9918 CD1 TYR C 282 −29.531 38.953 −79.536 1.00 24.03 C ATOM 9919 CE1 TYR C 282 −28.472 39.350 −78.743 1.00 23.57 C ATOM 9920 CZ TYR C 282 −27.267 38.679 −78.825 1.00 23.46 C ATOM 9921 OH TYR C 282 −26.216 39.083 −78.025 1.00 24.10 O ATOM 9922 CE2 TYR C 282 −27.115 37.612 −79.695 1.00 23.40 C ATOM 9923 CD2 TYR C 282 −28.180 37.223 −80.491 1.00 23.56 C ATOM 9924 C TYR C 282 −33.067 37.558 −81.545 1.00 27.06 C ATOM 9925 O TYR C 282 −33.466 38.686 −81.882 1.00 27.49 O ATOM 9926 N ARG C 283 −33.588 36.425 −82.022 1.00 27.46 N ATOM 9927 CA ARG C 283 −34.729 36.410 −82.928 1.00 28.87 C ATOM 9928 CB ARG C 283 −34.890 35.034 −83.557 1.00 30.00 C ATOM 9929 CG ARG C 283 −36.146 34.846 −84.390 1.00 32.61 C ATOM 9930 CD ARG C 283 −35.867 34.874 −85.889 1.00 36.71 C ATOM 9931 NE ARG C 283 −36.430 33.684 −86.541 1.00 39.75 N ATOM 9932 CZ ARG C 283 −35.709 32.760 −87.185 1.00 43.26 C ATOM 9933 NH1 ARG C 283 −36.313 31.704 −87.724 1.00 45.47 N ATOM 9934 NH2 ARG C 283 −34.385 32.890 −87.307 1.00 42.99 N ATOM 9935 C ARG C 283 −36.029 36.848 −82.231 1.00 30.12 C ATOM 9936 O ARG C 283 −36.828 37.591 −82.814 1.00 31.39 O ATOM 9937 N VAL C 284 −36.252 36.401 −80.993 1.00 29.48 N ATOM 9938 CA VAL C 284 −37.460 36.822 −80.281 1.00 28.39 C ATOM 9939 CB VAL C 284 −37.990 35.789 −79.242 1.00 28.16 C ATOM 9940 CG1 VAL C 284 −37.629 34.363 −79.644 1.00 26.88 C ATOM 9941 CG2 VAL C 284 −37.524 36.108 −77.828 1.00 27.84 C ATOM 9942 C VAL C 284 −37.273 38.196 −79.665 1.00 28.39 C ATOM 9943 O VAL C 284 −38.252 38.892 −79.399 1.00 29.42 O ATOM 9944 N ALA C 285 −36.018 38.587 −79.453 1.00 27.76 N ATOM 9945 CA ALA C 285 −35.708 39.926 −78.993 1.00 28.24 C ATOM 9946 CB ALA C 285 −34.216 40.081 −78.815 1.00 28.14 C ATOM 9947 C ALA C 285 −36.238 40.972 −79.983 1.00 29.97 C ATOM 9948 O ALA C 285 −36.834 41.983 −79.583 1.00 30.58 O ATOM 9949 N ALA C 286 −36.025 40.718 −81.274 1.00 30.69 N ATOM 9950 CA ALA C 286 −36.448 41.637 −82.327 1.00 31.68 C ATOM 9951 CB ALA C 286 −35.699 41.330 −83.616 1.00 30.93 C ATOM 9952 C ALA C 286 −37.977 41.636 −82.555 1.00 33.39 C ATOM 9953 O ALA C 286 −38.528 42.597 −83.087 1.00 34.59 O ATOM 9954 N CYS C 287 −38.644 40.556 −82.150 1.00 34.85 N ATOM 9955 CA CYS C 287 −40.098 40.439 −82.244 1.00 35.87 C ATOM 9956 CB CYS C 287 −40.529 38.986 −82.079 1.00 37.35 C ATOM 9957 SG CYS C 287 −40.231 37.965 −83.518 1.00 43.15 S ATOM 9958 C CYS C 287 −40.821 41.253 −81.184 1.00 36.43 C ATOM 9959 O CYS C 287 −41.879 41.824 −81.452 1.00 37.84 O ATOM 9960 N LEU C 288 −40.276 41.267 −79.971 1.00 35.03 N ATOM 9961 CA LEU C 288 −40.991 41.819 −78.836 1.00 35.07 C ATOM 9962 CB LEU C 288 −40.237 41.545 −77.545 1.00 34.67 C ATOM 9963 CG LEU C 288 −40.311 40.153 −76.947 1.00 35.16 C ATOM 9964 CD1 LEU C 288 −39.866 40.248 −75.495 1.00 35.61 C ATOM 9965 CD2 LEU C 288 −41.713 39.564 −77.056 1.00 35.42 C ATOM 9966 C LEU C 288 −41.216 43.312 −78.976 1.00 35.84 C ATOM 9967 O LEU C 288 −40.243 44.062 −79.061 1.00 36.33 O ATOM 9968 N PRO C 289 −42.501 43.745 −79.006 1.00 36.70 N ATOM 9969 CA PRO C 289 −42.866 45.157 −79.014 1.00 36.03 C ATOM 9970 CB PRO C 289 −44.295 45.137 −78.500 1.00 35.97 C ATOM 9971 CG PRO C 289 −44.848 43.871 −79.077 1.00 35.67 C ATOM 9972 CD PRO C 289 −43.699 42.890 −79.160 1.00 36.35 C ATOM 9973 C PRO C 289 −41.951 46.016 −78.139 1.00 37.10 C ATOM 9974 O PRO C 289 −41.009 46.593 −78.676 1.00 40.90 O ATOM 9975 N ILE C 290 −42.191 46.086 −76.828 1.00 34.72 N ATOM 9976 CA ILE C 290 −41.410 46.967 −75.901 1.00 34.74 C ATOM 9977 CB ILE C 290 −40.328 46.195 −75.105 1.00 34.13 C ATOM 9978 CG1 ILE C 290 −39.263 45.599 −76.022 1.00 34.54 C ATOM 9979 CD1 ILE C 290 −38.103 44.973 −75.273 1.00 33.13 C ATOM 9980 CG2 ILE C 290 −40.966 45.120 −74.245 1.00 34.73 C ATOM 9981 C ILE C 290 −40.836 48.316 −76.419 1.00 35.35 C ATOM 9982 O ILE C 290 −40.934 48.662 −77.601 1.00 35.02 O ATOM 9983 N ASP C 291 −40.255 49.093 −75.513 1.00 35.99 N ATOM 9984 CA ASP C 291 −39.918 50.481 −75.825 1.00 37.77 C ATOM 9985 CB ASP C 291 −40.776 51.429 −74.986 1.00 39.91 C ATOM 9986 CG ASP C 291 −40.505 51.293 −73.510 1.00 43.06 C ATOM 9987 OD1 ASP C 291 −39.509 51.887 −73.043 1.00 44.32 O ATOM 9988 OD2 ASP C 291 −41.274 50.579 −72.822 1.00 45.28 O ATOM 9989 C ASP C 291 −38.432 50.813 −75.662 1.00 37.24 C ATOM 9990 O ASP C 291 −37.696 50.123 −74.953 1.00 36.37 O ATOM 9991 N ASP C 292 −38.015 51.896 −76.311 1.00 37.32 N ATOM 9992 CA ASP C 292 −36.608 52.286 −76.383 1.00 38.14 C ATOM 9993 CB ASP C 292 −36.464 53.716 −76.946 1.00 36.56 C ATOM 9994 C ASP C 292 −35.815 52.105 −75.068 1.00 38.37 C ATOM 9995 O ASP C 292 −34.622 51.799 −75.108 1.00 38.28 O ATOM 9996 N VAL C 293 −36.464 52.276 −73.915 1.00 37.99 N ATOM 9997 CA VAL C 293 −35.745 52.122 −72.635 1.00 38.63 C ATOM 9998 CB VAL C 293 −36.333 52.988 −71.472 1.00 38.57 C ATOM 9999 CG1 VAL C 293 −37.749 52.562 −71.100 1.00 38.29 C ATOM 10000 CG2 VAL C 293 −35.423 52.942 −70.245 1.00 36.68 C ATOM 10001 C VAL C 293 −35.542 50.656 −72.225 1.00 38.06 C ATOM 10002 O VAL C 293 −34.486 50.304 −71.700 1.00 37.75 O ATOM 10003 N LEU C 294 −36.550 49.816 −72.467 1.00 37.06 N ATOM 10004 CA LEU C 294 −36.437 48.381 −72.213 1.00 36.27 C ATOM 10005 CB LEU C 294 −37.814 47.716 −72.156 1.00 36.41 C ATOM 10006 CG LEU C 294 −38.719 47.862 −70.932 1.00 36.58 C ATOM 10007 CD1 LEU C 294 −40.001 47.085 −71.182 1.00 36.16 C ATOM 10008 CD2 LEU C 294 −38.047 47.391 −69.646 1.00 35.78 C ATOM 10009 C LEU C 294 −35.576 47.676 −73.268 1.00 36.41 C ATOM 10010 O LEU C 294 −34.881 46.705 −72.949 1.00 35.36 O ATOM 10011 N ARG C 295 −35.634 48.152 −74.518 1.00 35.14 N ATOM 10012 CA ARG C 295 −34.827 47.574 −75.597 1.00 34.94 C ATOM 10013 CB ARG C 295 −35.191 48.163 −76.969 1.00 35.66 C ATOM 10014 CG ARG C 295 −34.992 47.226 −78.168 1.00 35.06 C ATOM 10015 CD ARG C 295 −36.229 46.344 −78.378 1.00 37.48 C ATOM 10016 NE ARG C 295 −36.537 45.924 −79.761 1.00 36.88 N ATOM 10017 CZ ARG C 295 −35.851 46.254 −80.855 1.00 36.22 C ATOM 10018 NH1 ARG C 295 −34.772 47.021 −80.782 1.00 35.37 N ATOM 10019 NH2 ARG C 295 −36.245 45.797 −82.034 1.00 35.21 N ATOM 10020 C ARG C 295 −33.336 47.741 −75.329 1.00 34.76 C ATOM 10021 O ARG C 295 −32.547 46.870 −75.679 1.00 37.11 O ATOM 10022 N ILE C 296 −32.950 48.847 −74.699 1.00 33.40 N ATOM 10023 CA ILE C 296 −31.546 49.065 −74.352 1.00 34.38 C ATOM 10024 CB ILE C 296 −31.262 50.534 −73.955 1.00 33.46 C ATOM 10025 CG1 ILE C 296 −31.535 51.464 −75.143 1.00 33.50 C ATOM 10026 CD1 ILE C 296 −31.491 52.944 −74.816 1.00 34.05 C ATOM 10027 CG2 ILE C 296 −29.822 50.704 −73.475 1.00 32.80 C ATOM 10028 C ILE C 296 −31.074 48.080 −73.267 1.00 35.96 C ATOM 10029 O ILE C 296 −29.898 47.683 −73.244 1.00 36.60 O ATOM 10030 N GLN C 297 −32.001 47.670 −72.399 1.00 36.43 N ATOM 10031 CA GLN C 297 −31.728 46.672 −71.360 1.00 37.07 C ATOM 10032 CB GLN C 297 −32.917 46.518 −70.415 1.00 39.07 C ATOM 10033 CG GLN C 297 −33.566 47.823 −69.995 1.00 40.39 C ATOM 10034 CD GLN C 297 −32.981 48.395 −68.727 1.00 40.49 C ATOM 10035 OE1 GLN C 297 −33.653 48.444 −67.700 1.00 40.70 O ATOM 10036 NE2 GLN C 297 −31.727 48.836 −68.790 1.00 41.16 N ATOM 10037 C GLN C 297 −31.348 45.304 −71.926 1.00 37.03 C ATOM 10038 O GLN C 297 −30.287 44.786 −71.591 1.00 37.89 O ATOM 10039 N LEU C 298 −32.196 44.712 −72.774 1.00 36.05 N ATOM 10040 CA LEU C 298 −31.860 43.402 −73.357 1.00 35.64 C ATOM 10041 CB LEU C 298 −32.933 42.866 −74.305 1.00 36.93 C ATOM 10042 CG LEU C 298 −34.401 43.177 −74.149 1.00 37.23 C ATOM 10043 CD1 LEU C 298 −34.699 44.324 −75.091 1.00 38.13 C ATOM 10044 CD2 LEU C 298 −35.217 41.954 −74.529 1.00 36.79 C ATOM 10045 C LEU C 298 −30.566 43.484 −74.130 1.00 34.52 C ATOM 10046 O LEU C 298 −29.747 42.567 −74.087 1.00 33.95 O ATOM 10047 N LEU C 299 −30.410 44.581 −74.863 1.00 33.13 N ATOM 10048 CA LEU C 299 −29.192 44.847 −75.600 1.00 31.13 C ATOM 10049 CB LEU C 299 −29.306 46.174 −76.352 1.00 30.94 C ATOM 10050 CG LEU C 299 −28.741 46.171 −77.774 1.00 30.82 C ATOM 10051 CD1 LEU C 299 −27.316 46.693 −77.815 1.00 29.78 C ATOM 10052 CD2 LEU C 299 −28.844 44.784 −78.409 1.00 31.72 C ATOM 10053 C LEU C 299 −27.977 44.833 −74.670 1.00 28.89 C ATOM 10054 O LEU C 299 −26.945 44.259 −75.011 1.00 27.64 O ATOM 10055 N LYS C 300 −28.123 45.440 −73.492 1.00 27.65 N ATOM 10056 CA LYS C 300 −27.107 45.370 −72.444 1.00 27.32 C ATOM 10057 CB LYS C 300 −27.504 46.232 −71.242 1.00 28.97 C ATOM 10058 CG LYS C 300 −27.272 47.728 −71.388 1.00 30.72 C ATOM 10059 CD LYS C 300 −27.310 48.413 −70.023 1.00 32.19 C ATOM 10060 CE LYS C 300 −27.893 49.822 −70.121 1.00 33.84 C ATOM 10061 NZ LYS C 300 −27.718 50.643 −68.882 1.00 33.39 N ATOM 10062 C LYS C 300 −26.821 43.934 −71.961 1.00 25.72 C ATOM 10063 O LYS C 300 −25.726 43.663 −71.465 1.00 25.16 O ATOM 10064 N ILE C 301 −27.801 43.033 −72.097 1.00 24.42 N ATOM 10065 CA ILE C 301 −27.667 41.637 −71.630 1.00 23.75 C ATOM 10066 CB ILE C 301 −29.024 40.897 −71.577 1.00 23.63 C ATOM 10067 CG1 ILE C 301 −29.974 41.562 −70.579 1.00 23.57 C ATOM 10068 CD1 ILE C 301 −31.429 41.168 −70.756 1.00 23.28 C ATOM 10069 CG2 ILE C 301 −28.825 39.432 −71.209 1.00 23.63 C ATOM 10070 C ILE C 301 −26.689 40.828 −72.486 1.00 23.44 C ATOM 10071 O ILE C 301 −26.796 40.787 −73.721 1.00 23.47 O ATOM 10072 N GLY C 302 −25.745 40.172 −71.817 1.00 23.28 N ATOM 10073 CA GLY C 302 −24.673 39.453 −72.511 1.00 22.91 C ATOM 10074 C GLY C 302 −24.914 37.970 −72.678 1.00 21.86 C ATOM 10075 O GLY C 302 −24.290 37.323 −73.512 1.00 21.82 O ATOM 10076 N SER C 303 −25.824 37.433 −71.881 1.00 21.13 N ATOM 10077 CA SER C 303 −26.053 36.012 −71.863 1.00 20.93 C ATOM 10078 CB SER C 303 −26.044 35.500 −70.427 1.00 20.48 C ATOM 10079 OG SER C 303 −26.274 34.107 −70.406 1.00 20.30 O ATOM 10080 C SER C 303 −27.356 35.604 −72.554 1.00 21.36 C ATOM 10081 O SER C 303 −28.402 36.243 −72.382 1.00 21.74 O ATOM 10082 N ALA C 304 −27.279 34.517 −73.320 1.00 21.06 N ATOM 10083 CA ALA C 304 −28.448 33.898 −73.918 1.00 19.98 C ATOM 10084 CB ALA C 304 −28.052 32.647 −74.687 1.00 19.81 C ATOM 10085 C ALA C 304 −29.477 33.567 −72.852 1.00 19.86 C ATOM 10086 O ALA C 304 −30.647 33.863 −73.036 1.00 20.67 O ATOM 10087 N ILE C 305 −29.035 32.971 −71.737 1.00 19.24 N ATOM 10088 CA ILE C 305 −29.942 32.514 −70.671 1.00 18.55 C ATOM 10089 CB ILE C 305 −29.201 31.781 −69.515 1.00 18.58 C ATOM 10090 CG1 ILE C 305 −28.263 30.669 −70.024 1.00 18.40 C ATOM 10091 CD1 ILE C 305 −28.941 29.551 −70.784 1.00 18.48 C ATOM 10092 CG2 ILE C 305 −30.191 31.270 −68.486 1.00 18.36 C ATOM 10093 C ILE C 305 −30.707 33.683 −70.072 1.00 18.36 C ATOM 10094 O ILE C 305 −31.922 33.622 −69.937 1.00 17.96 O ATOM 10095 N GLN C 306 −29.983 34.738 −69.707 1.00 18.57 N ATOM 10096 CA GLN C 306 −30.591 35.951 −69.156 1.00 19.27 C ATOM 10097 CB GLN C 306 −29.517 36.894 −68.615 1.00 19.46 C ATOM 10098 CG GLN C 306 −28.913 36.454 −67.284 1.00 19.54 C ATOM 10099 CD GLN C 306 −27.729 37.305 −66.849 1.00 19.08 C ATOM 10100 OE1 GLN C 306 −26.943 37.777 −67.678 1.00 19.16 O ATOM 10101 NE2 GLN C 306 −27.588 37.493 −65.540 1.00 18.86 N ATOM 10102 C GLN C 306 −31.448 36.684 −70.189 1.00 19.90 C ATOM 10103 O GLN C 306 −32.373 37.406 −69.830 1.00 20.22 O ATOM 10104 N ARG C 307 −31.123 36.503 −71.468 1.00 20.23 N ATOM 10105 CA ARG C 307 −31.916 37.046 −72.554 1.00 20.21 C ATOM 10106 CB ARG C 307 −31.145 36.958 −73.876 1.00 20.52 C ATOM 10107 CG ARG C 307 −31.461 38.075 −74.861 1.00 20.90 C ATOM 10108 CD ARG C 307 −30.519 38.089 −76.056 1.00 20.92 C ATOM 10109 NE ARG C 307 −29.161 38.498 −75.702 1.00 20.95 N ATOM 10110 CZ ARG C 307 −28.068 37.758 −75.902 1.00 21.30 C ATOM 10111 NH1 ARG C 307 −28.159 36.559 −76.476 1.00 20.76 N ATOM 10112 NH2 ARG C 307 −26.871 38.229 −75.550 1.00 21.22 N ATOM 10113 C ARG C 307 −33.265 36.319 −72.635 1.00 20.37 C ATOM 10114 O ARG C 307 −34.316 36.955 −72.576 1.00 21.50 O ATOM 10115 N LEU C 308 −33.227 34.992 −72.737 1.00 20.23 N ATOM 10116 CA LEU C 308 −34.438 34.155 −72.759 1.00 20.32 C ATOM 10117 CB LEU C 308 −34.073 32.673 −72.881 1.00 20.70 C ATOM 10118 CG LEU C 308 −33.268 32.244 −74.099 1.00 21.09 C ATOM 10119 CD1 LEU C 308 −32.603 30.903 −73.864 1.00 20.67 C ATOM 10120 CD2 LEU C 308 −34.166 32.199 −75.323 1.00 22.13 C ATOM 10121 C LEU C 308 −35.320 34.336 −71.532 1.00 20.13 C ATOM 10122 O LEU C 308 −36.537 34.437 −71.659 1.00 20.52 O ATOM 10123 N ARG C 309 −34.706 34.345 −70.349 1.00 19.90 N ATOM 10124 CA ARG C 309 −35.425 34.553 −69.090 1.00 20.13 C ATOM 10125 CB ARG C 309 −34.459 34.526 −67.896 1.00 18.99 C ATOM 10126 CG ARG C 309 −34.095 33.148 −67.380 1.00 17.70 C ATOM 10127 CD ARG C 309 −33.274 33.233 −66.101 1.00 17.13 C ATOM 10128 NE ARG C 309 −33.974 33.925 −65.023 1.00 16.78 N ATOM 10129 CZ ARG C 309 −34.872 33.362 −64.214 1.00 17.20 C ATOM 10130 NH1 ARG C 309 −35.456 34.079 −63.266 1.00 17.64 N ATOM 10131 NH2 ARG C 309 −35.204 32.083 −64.343 1.00 17.19 N ATOM 10132 C ARG C 309 −36.165 35.887 −69.116 1.00 21.15 C ATOM 10133 O ARG C 309 −37.388 35.933 −69.096 1.00 21.36 O ATOM 10134 N CYS C 310 −35.408 36.971 −69.178 1.00 22.99 N ATOM 10135 CA CYS C 310 −35.973 38.305 −69.264 1.00 25.31 C ATOM 10136 CB CYS C 310 −34.865 39.311 −69.532 1.00 26.45 C ATOM 10137 SG CYS C 310 −35.488 40.836 −70.235 1.00 31.22 S ATOM 10138 C CYS C 310 −37.061 38.420 −70.337 1.00 25.64 C ATOM 10139 O CYS C 310 −38.079 39.073 −70.129 1.00 26.48 O ATOM 10140 N GLU C 311 −36.832 37.787 −71.481 1.00 26.35 N ATOM 10141 CA GLU C 311 −37.833 37.706 −72.553 1.00 26.99 C ATOM 10142 CB GLU C 311 −37.230 37.072 −73.804 1.00 28.74 C ATOM 10143 CG GLU C 311 −36.550 38.082 −74.711 1.00 30.40 C ATOM 10144 CD GLU C 311 −35.443 37.470 −75.536 1.00 32.39 C ATOM 10145 OE1 GLU C 311 −34.517 38.220 −75.927 1.00 32.28 O ATOM 10146 OE2 GLU C 311 −35.500 36.239 −75.788 1.00 33.97 O ATOM 10147 C GLU C 311 −39.126 36.985 −72.184 1.00 25.49 C ATOM 10148 O GLU C 311 −40.193 37.396 −72.603 1.00 25.23 O ATOM 10149 N LEU C 312 −39.030 35.897 −71.431 1.00 24.86 N ATOM 10150 CA LEU C 312 −40.230 35.243 −70.909 1.00 24.74 C ATOM 10151 CB LEU C 312 −39.899 33.952 −70.159 1.00 23.78 C ATOM 10152 CG LEU C 312 −40.150 32.627 −70.872 1.00 23.40 C ATOM 10153 CD1 LEU C 312 −39.717 31.508 −69.953 1.00 23.33 C ATOM 10154 CD2 LEU C 312 −41.603 32.441 −71.284 1.00 22.97 C ATOM 10155 C LEU C 312 −40.998 36.168 −69.992 1.00 24.49 C ATOM 10156 O LEU C 312 −42.216 36.217 −70.043 1.00 25.14 O ATOM 10157 N ASP C 313 −40.271 36.896 −69.154 1.00 24.85 N ATOM 10158 CA ASP C 313 −40.867 37.842 −68.223 1.00 26.03 C ATOM 10159 CB ASP C 313 −39.764 38.598 −67.491 1.00 26.34 C ATOM 10160 CG ASP C 313 −40.217 39.140 −66.176 1.00 26.52 C ATOM 10161 OD1 ASP C 313 −40.949 40.145 −66.161 1.00 27.11 O ATOM 10162 OD2 ASP C 313 −39.827 38.564 −65.148 1.00 27.32 O ATOM 10163 C ASP C 313 −41.794 38.832 −68.945 1.00 26.70 C ATOM 10164 O ASP C 313 −42.977 38.955 −68.606 1.00 26.90 O ATOM 10165 N ILE C 314 −41.252 39.517 −69.948 1.00 26.55 N ATOM 10166 CA ILE C 314 −42.011 40.486 −70.725 1.00 27.26 C ATOM 10167 CB ILE C 314 −41.133 41.135 −71.811 1.00 26.78 C ATOM 10168 CG1 ILE C 314 −40.254 42.222 −71.190 1.00 26.02 C ATOM 10169 CD1 ILE C 314 −38.883 42.325 −71.818 1.00 25.58 C ATOM 10170 CG2 ILE C 314 −41.992 41.714 −72.928 1.00 27.03 C ATOM 10171 C ILE C 314 −43.279 39.883 −71.341 1.00 28.45 C ATOM 10172 O ILE C 314 −44.343 40.503 −71.295 1.00 29.63 O ATOM 10173 N MET C 315 −43.162 38.674 −71.894 1.00 28.95 N ATOM 10174 CA MET C 315 −44.286 37.985 −72.539 1.00 29.61 C ATOM 10175 CB MET C 315 −43.816 36.724 −73.255 1.00 30.58 C ATOM 10176 CG MET C 315 −43.066 37.003 −74.546 1.00 31.00 C ATOM 10177 SD MET C 315 −42.417 35.497 −75.288 1.00 30.79 S ATOM 10178 CE MET C 315 −40.876 36.143 −75.920 1.00 31.83 C ATOM 10179 C MET C 315 −45.427 37.645 −71.588 1.00 29.96 C ATOM 10180 O MET C 315 −46.585 37.631 −71.995 1.00 30.79 O ATOM 10181 N ASN C 316 −45.101 37.367 −70.329 1.00 30.06 N ATOM 10182 CA ASN C 316 −46.127 37.206 −69.304 1.00 30.44 C ATOM 10183 CB ASN C 316 −45.617 36.350 −68.144 1.00 29.69 C ATOM 10184 CG ASN C 316 −44.856 35.123 −68.609 1.00 29.04 C ATOM 10185 OD1 ASN C 316 −45.088 34.611 −69.705 1.00 28.78 O ATOM 10186 ND2 ASN C 316 −43.932 34.648 −67.776 1.00 28.93 N ATOM 10187 C ASN C 316 −46.615 38.554 −68.784 1.00 31.74 C ATOM 10188 O ASN C 316 −47.818 38.791 −68.719 1.00 32.40 O ATOM 10189 N LYS C 317 −45.675 39.445 −68.453 1.00 33.15 N ATOM 10190 CA LYS C 317 −45.988 40.683 −67.731 1.00 34.23 C ATOM 10191 CB LYS C 317 −44.776 41.153 −66.900 1.00 32.44 C ATOM 10192 C LYS C 317 −46.558 41.839 −68.583 1.00 36.18 C ATOM 10193 O LYS C 317 −47.017 42.832 −68.031 1.00 37.68 O ATOM 10194 N CYS C 318 −46.560 41.713 −69.909 1.00 37.88 N ATOM 10195 CA CYS C 318 −46.960 42.846 −70.763 1.00 38.72 C ATOM 10196 CB CYS C 318 −45.746 43.384 −71.518 1.00 39.19 C ATOM 10197 SG CYS C 318 −44.485 44.100 −70.444 1.00 41.50 S ATOM 10198 C CYS C 318 −48.116 42.577 −71.740 1.00 39.26 C ATOM 10199 O CYS C 318 −47.918 42.556 −72.960 1.00 40.67 O ATOM 10200 N THR C 319 −49.324 42.423 −71.207 1.00 38.30 N ATOM 10201 CA THR C 319 −50.478 42.049 −72.035 1.00 37.99 C ATOM 10202 CB THR C 319 −51.581 41.372 −71.203 1.00 38.81 C ATOM 10203 OG1 THR C 319 −52.170 42.329 −70.312 1.00 39.89 O ATOM 10204 CG2 THR C 319 −51.001 40.204 −70.409 1.00 40.26 C ATOM 10205 C THR C 319 −51.099 43.174 −72.896 1.00 37.48 C ATOM 10206 O THR C 319 −51.687 42.890 −73.946 1.00 37.41 O ATOM 10207 N SER C 320 −50.981 44.431 −72.461 1.00 35.49 N ATOM 10208 CA SER C 320 −51.559 45.561 −73.210 1.00 32.94 C ATOM 10209 CB SER C 320 −52.553 46.331 −72.342 1.00 31.59 C ATOM 10210 OG SER C 320 −51.914 47.378 −71.648 1.00 31.98 O ATOM 10211 C SER C 320 −50.499 46.507 −73.822 1.00 32.42 C ATOM 10212 O SER C 320 −49.314 46.432 −73.476 1.00 32.80 O ATOM 10213 N LEU C 321 −50.941 47.382 −74.734 1.00 30.81 N ATOM 10214 CA LEU C 321 −50.062 48.300 −75.473 1.00 28.89 C ATOM 10215 CB LEU C 321 −49.645 47.669 −76.802 1.00 28.75 C ATOM 10216 CG LEU C 321 −48.589 46.561 −76.788 1.00 28.35 C ATOM 10217 CD1 LEU C 321 −48.677 45.748 −78.067 1.00 28.82 C ATOM 10218 CD2 LEU C 321 −47.187 47.118 −76.609 1.00 27.54 C ATOM 10219 C LEU C 321 −50.761 49.627 −75.745 1.00 28.02 C ATOM 10220 O LEU C 321 −51.854 49.640 −76.303 1.00 27.49 O ATOM 10221 N CYS C 322 −50.199 50.812 −75.419 1.00 28.00 N ATOM 10222 CA CYS C 322 −50.929 52.143 −75.567 1.00 27.86 C ATOM 10223 CB CYS C 322 −51.485 52.598 −74.220 1.00 28.61 C ATOM 10224 SG CYS C 322 −51.570 51.417 −72.879 1.00 29.62 S ATOM 10225 C CYS C 322 −50.269 53.419 −76.203 1.00 27.28 C ATOM 10226 O CYS C 322 −49.110 53.368 −76.437 1.00 27.58 O ATOM 10227 O CYS C 323 −49.014 54.729 −75.263 1.00 30.00 O ATOM 10228 N CYS C 323 −51.010 54.459 −76.543 1.00 30.00 N ATOM 10229 CA CYS C 323 −50.249 55.511 −77.146 1.00 30.00 C ATOM 10230 C CYS C 323 −49.039 55.460 −76.252 1.00 30.00 C ATOM 10231 CB CYS C 323 −50.885 56.872 −77.051 1.00 20.00 C ATOM 10232 SG CYS C 323 −49.691 58.075 −77.649 1.00 20.00 S ATOM 10233 N LYS C 324 −48.028 56.226 −76.591 1.00 28.55 N ATOM 10234 CA LYS C 324 −46.840 56.257 −75.770 1.00 28.81 C ATOM 10235 CB LYS C 324 −45.628 56.075 −76.630 1.00 30.57 C ATOM 10236 CG LYS C 324 −44.475 55.416 −75.919 1.00 32.15 C ATOM 10237 CD LYS C 324 −43.337 56.369 −75.729 1.00 33.14 C ATOM 10238 CE LYS C 324 −42.094 55.607 −75.403 1.00 34.39 C ATOM 10239 NZ LYS C 324 −41.941 54.532 −76.413 1.00 37.31 N ATOM 10240 C LYS C 324 −46.811 57.625 −75.221 1.00 28.84 C ATOM 10241 O LYS C 324 −46.538 57.849 −74.068 1.00 28.50 O ATOM 10242 N GLN C 325 −47.097 58.566 −76.099 1.00 28.91 N ATOM 10243 CA GLN C 325 −47.386 59.908 −75.720 1.00 29.27 C ATOM 10244 CB GLN C 325 −47.964 60.651 −76.892 1.00 29.31 C ATOM 10245 CG GLN C 325 −48.329 62.077 −76.578 1.00 30.12 C ATOM 10246 CD GLN C 325 −47.121 62.932 −76.399 1.00 30.82 C ATOM 10247 OE1 GLN C 325 −46.041 62.584 −76.831 1.00 32.09 O ATOM 10248 NE2 GLN C 325 −47.295 64.051 −75.756 1.00 30.42 N ATOM 10249 C GLN C 325 −48.421 59.689 −74.677 1.00 29.77 C ATOM 10250 O GLN C 325 −48.343 58.704 −74.000 1.00 31.34 O ATOM 10251 O CYS C 326 −50.813 58.254 −74.443 1.00 30.00 O ATOM 10252 N CYS C 326 −49.376 60.622 −74.552 1.00 30.00 N ATOM 10253 CA CYS C 326 −50.516 60.461 −73.649 1.00 30.00 C ATOM 10254 C CYS C 326 −50.590 58.979 −73.482 1.00 30.00 C ATOM 10255 CB CYS C 326 −51.807 61.021 −74.265 1.00 20.00 C ATOM 10256 SG CYS C 326 −53.080 59.832 −74.782 1.00 20.00 S ATOM 10257 N GLN C 327 −50.344 58.493 −72.285 1.00 33.71 N ATOM 10258 CA GLN C 327 −49.940 57.119 −72.213 1.00 35.17 C ATOM 10259 CB GLN C 327 −48.576 57.051 −71.543 1.00 35.36 C ATOM 10260 CG GLN C 327 −48.613 57.030 −70.042 1.00 35.93 C ATOM 10261 CD GLN C 327 −47.304 57.405 −69.443 1.00 37.72 C ATOM 10262 OE1 GLN C 327 −46.651 58.307 −69.915 1.00 39.64 O ATOM 10263 NE2 GLN C 327 −46.911 56.716 −68.400 1.00 37.96 N ATOM 10264 C GLN C 327 −50.836 56.102 −71.564 1.00 36.84 C ATOM 10265 O GLN C 327 −50.459 54.961 −71.485 1.00 38.04 O ATOM 10266 N GLU C 328 −51.993 56.499 −71.079 1.00 38.65 N ATOM 10267 CA GLU C 328 −52.828 55.571 −70.341 1.00 40.08 C ATOM 10268 CB GLU C 328 −53.379 56.225 −69.069 1.00 42.82 C ATOM 10269 CG GLU C 328 −52.335 56.504 −67.990 1.00 44.75 C ATOM 10270 CD GLU C 328 −52.049 55.307 −67.105 1.00 46.60 C ATOM 10271 OE1 GLU C 328 −50.866 55.031 −66.859 1.00 47.60 O ATOM 10272 OE2 GLU C 328 −52.996 54.638 −66.650 1.00 47.01 O ATOM 10273 C GLU C 328 −53.934 55.044 −71.215 1.00 38.58 C ATOM 10274 O GLU C 328 −55.000 54.719 −70.755 1.00 39.47 O ATOM 10275 N THR C 329 −53.636 54.933 −72.492 1.00 37.05 N ATOM 10276 CA THR C 329 −54.638 54.654 −73.538 1.00 35.59 C ATOM 10277 CB THR C 329 −54.863 55.893 −74.440 1.00 35.01 C ATOM 10278 OG1 THR C 329 −55.454 56.942 −73.656 1.00 34.92 O ATOM 10279 CG2 THR C 329 −55.772 55.558 −75.637 1.00 33.48 C ATOM 10280 C THR C 329 −54.349 53.391 −74.373 1.00 34.31 C ATOM 10281 O THR C 329 −53.374 53.338 −75.120 1.00 34.17 O ATOM 10282 N GLU C 330 −55.234 52.399 −74.256 1.00 32.74 N ATOM 10283 CA GLU C 330 −55.038 51.070 −74.852 1.00 31.44 C ATOM 10284 CB GLU C 330 −55.945 50.054 −74.160 1.00 32.33 C ATOM 10285 CG GLU C 330 −55.767 48.626 −74.642 1.00 33.30 C ATOM 10286 CD GLU C 330 −56.359 47.609 −73.687 1.00 33.72 C ATOM 10287 OE1 GLU C 330 −55.567 46.890 −73.048 1.00 33.81 O ATOM 10288 OE2 GLU C 330 −57.608 47.535 −73.566 1.00 33.76 O ATOM 10289 C GLU C 330 −55.266 51.021 −76.360 1.00 29.81 C ATOM 10290 O GLU C 330 −56.343 51.358 −76.843 1.00 29.73 O ATOM 10291 N ILE C 331 −54.248 50.583 −77.095 1.00 28.55 N ATOM 10292 CA ILE C 331 −54.343 50.467 −78.552 1.00 28.42 C ATOM 10293 CB ILE C 331 −53.049 50.955 −79.280 1.00 28.07 C ATOM 10294 CG1 ILE C 331 −52.582 52.331 −78.766 1.00 28.27 C ATOM 10295 CD1 ILE C 331 −53.463 53.516 −79.141 1.00 28.42 C ATOM 10296 CG2 ILE C 331 −53.231 50.970 −80.798 1.00 27.94 C ATOM 10297 C ILE C 331 −54.679 49.023 −78.942 1.00 28.11 C ATOM 10298 O ILE C 331 −55.602 48.781 −79.722 1.00 27.74 O ATOM 10299 N THR C 332 −53.937 48.071 −78.383 1.00 28.31 N ATOM 10300 CA THR C 332 −54.138 46.654 −78.682 1.00 29.06 C ATOM 10301 CB THR C 332 −53.504 46.270 −80.044 1.00 29.15 C ATOM 10302 OG1 THR C 332 −53.924 44.954 −80.422 1.00 30.59 O ATOM 10303 CG2 THR C 332 −51.979 46.323 −79.987 1.00 29.46 C ATOM 10304 C THR C 332 −53.649 45.740 −77.535 1.00 29.20 C ATOM 10305 O THR C 332 −53.127 46.221 −76.528 1.00 28.24 O ATOM 10306 N THR C 333 −53.848 44.432 −77.683 1.00 30.52 N ATOM 10307 CA THR C 333 −53.397 43.465 −76.673 1.00 32.61 C ATOM 10308 CB THR C 333 −54.568 42.827 −75.873 1.00 31.18 C ATOM 10309 OG1 THR C 333 −55.584 42.356 −76.770 1.00 30.23 O ATOM 10310 CG2 THR C 333 −55.167 43.828 −74.906 1.00 30.69 C ATOM 10311 C THR C 333 −52.524 42.358 −77.265 1.00 34.87 C ATOM 10312 O THR C 333 −52.358 42.262 −78.489 1.00 34.02 O ATOM 10313 N LYS C 334 −51.961 41.540 −76.371 1.00 36.51 N ATOM 10314 CA LYS C 334 −51.210 40.348 −76.736 1.00 37.13 C ATOM 10315 CB LYS C 334 −50.842 39.555 −75.478 1.00 38.57 C ATOM 10316 CG LYS C 334 −50.070 38.267 −75.729 1.00 39.10 C ATOM 10317 CD LYS C 334 −49.551 37.657 −74.429 1.00 39.18 C ATOM 10318 CE LYS C 334 −48.358 36.747 −74.699 1.00 39.28 C ATOM 10319 NZ LYS C 334 −47.892 36.022 −73.490 1.00 38.25 N ATOM 10320 C LYS C 334 −52.060 39.496 −77.650 1.00 37.78 C ATOM 10321 O LYS C 334 −51.610 39.094 −78.725 1.00 38.45 O ATOM 10322 N ASN C 335 −53.301 39.252 −77.226 1.00 37.48 N ATOM 10323 CA ASN C 335 −54.260 38.467 −78.003 1.00 38.20 C ATOM 10324 CB ASN C 335 −55.683 38.708 −77.493 1.00 39.97 C ATOM 10325 CG ASN C 335 −55.892 38.217 −76.077 1.00 40.91 C ATOM 10326 OD1 ASN C 335 −56.974 38.392 −75.510 1.00 41.71 O ATOM 10327 ND2 ASN C 335 −54.865 37.597 −75.496 1.00 39.92 N ATOM 10328 C ASN C 335 −54.224 38.739 −79.506 1.00 37.45 C ATOM 10329 O ASN C 335 −54.407 37.823 −80.306 1.00 38.02 O ATOM 10330 N GLU C 336 −53.982 39.995 −79.882 1.00 36.22 N ATOM 10331 CA GLU C 336 −54.143 40.423 −81.274 1.00 35.67 C ATOM 10332 CB GLU C 336 −54.736 41.827 −81.335 1.00 37.40 C ATOM 10333 CG GLU C 336 −56.005 41.993 −80.503 1.00 41.69 C ATOM 10334 CD GLU C 336 −57.188 41.141 −80.975 1.00 43.76 C ATOM 10335 OE1 GLU C 336 −58.269 41.249 −80.348 1.00 45.56 O ATOM 10336 OE2 GLU C 336 −57.057 40.376 −81.965 1.00 44.52 O ATOM 10337 C GLU C 336 −52.887 40.317 −82.138 1.00 32.73 C ATOM 10338 O GLU C 336 −52.972 40.335 −83.364 1.00 31.22 O ATOM 10339 N ILE C 337 −51.733 40.197 −81.493 1.00 31.40 N ATOM 10340 CA ILE C 337 −50.459 40.092 −82.196 1.00 31.48 C ATOM 10341 CB ILE C 337 −49.252 40.134 −81.221 1.00 30.92 C ATOM 10342 CG1 ILE C 337 −49.192 41.468 −80.484 1.00 30.27 C ATOM 10343 CD1 ILE C 337 −48.276 41.453 −79.285 1.00 30.16 C ATOM 10344 CG2 ILE C 337 −47.940 39.898 −81.956 1.00 30.13 C ATOM 10345 C ILE C 337 −50.405 38.806 −83.017 1.00 32.03 C ATOM 10346 O ILE C 337 −50.673 37.711 −82.503 1.00 32.55 O ATOM 10347 N PHE C 338 −50.068 38.950 −84.295 1.00 31.24 N ATOM 10348 CA PHE C 338 −49.843 37.803 −85.156 1.00 31.26 C ATOM 10349 CB PHE C 338 −51.139 37.423 −85.889 1.00 29.91 C ATOM 10350 CG PHE C 338 −51.416 38.249 −87.103 1.00 29.35 C ATOM 10351 CD1 PHE C 338 −51.610 39.620 −87.003 1.00 29.62 C ATOM 10352 CE1 PHE C 338 −51.849 40.384 −88.133 1.00 29.58 C ATOM 10353 CZ PHE C 338 −51.911 39.779 −89.375 1.00 29.65 C ATOM 10354 CE2 PHE C 338 −51.727 38.412 −89.487 1.00 29.61 C ATOM 10355 CD2 PHE C 338 −51.477 37.656 −88.354 1.00 29.42 C ATOM 10356 C PHE C 338 −48.688 38.085 −86.131 1.00 31.80 C ATOM 10357 O PHE C 338 −48.403 39.246 −86.455 1.00 30.79 O ATOM 10358 N SER C 339 −48.023 37.019 −86.575 1.00 32.10 N ATOM 10359 CA SER C 339 −46.869 37.124 −87.463 1.00 31.91 C ATOM 10360 CB SER C 339 −45.873 35.998 −87.188 1.00 31.13 C ATOM 10361 OG SER C 339 −45.839 35.703 −85.801 1.00 32.80 O ATOM 10362 C SER C 339 −47.316 37.061 −88.901 1.00 32.38 C ATOM 10363 O SER C 339 −47.450 35.989 −89.469 1.00 32.27 O ATOM 10364 N LEU C 340 −47.556 38.219 −89.493 1.00 34.71 N ATOM 10365 CA LEU C 340 −47.859 38.274 −90.908 1.00 35.52 C ATOM 10366 CB LEU C 340 −48.348 39.662 −91.299 1.00 35.93 C ATOM 10367 CG LEU C 340 −49.641 39.766 −92.106 1.00 36.00 C ATOM 10368 CD1 LEU C 340 −49.574 40.991 −93.003 1.00 35.67 C ATOM 10369 CD2 LEU C 340 −49.928 38.510 −92.917 1.00 35.09 C ATOM 10370 C LEU C 340 −46.588 37.947 −91.662 1.00 36.98 C ATOM 10371 O LEU C 340 −46.620 37.231 −92.658 1.00 39.23 O ATOM 10372 N SER C 341 −45.468 38.474 −91.171 1.00 37.68 N ATOM 10373 CA SER C 341 −44.161 38.147 −91.712 1.00 37.80 C ATOM 10374 CB SER C 341 −43.172 39.297 −91.482 1.00 38.13 C ATOM 10375 OG SER C 341 −41.822 38.877 −91.638 1.00 37.74 O ATOM 10376 C SER C 341 −43.647 36.885 −91.058 1.00 38.72 C ATOM 10377 O SER C 341 −43.706 36.741 −89.830 1.00 38.63 O ATOM 10378 N LEU C 342 −43.165 35.973 −91.899 1.00 40.54 N ATOM 10379 CA LEU C 342 −42.340 34.835 −91.486 1.00 43.39 C ATOM 10380 CB LEU C 342 −41.423 34.430 −92.647 1.00 44.01 C ATOM 10381 CG LEU C 342 −41.111 32.959 −92.938 1.00 44.26 C ATOM 10382 CD1 LEU C 342 −40.377 32.869 −94.269 1.00 43.78 C ATOM 10383 CD2 LEU C 342 −40.311 32.287 −91.822 1.00 44.08 C ATOM 10384 C LEU C 342 −41.481 35.143 −90.245 1.00 45.31 C ATOM 10385 O LEU C 342 −41.512 34.399 −89.260 1.00 44.98 O ATOM 10386 N CYS C 343 −40.733 36.247 −90.300 1.00 46.18 N ATOM 10387 CA CYS C 343 −39.808 36.643 −89.230 1.00 46.90 C ATOM 10388 CB CYS C 343 −39.038 37.880 −89.655 1.00 49.16 C ATOM 10389 SG CYS C 343 −38.070 37.582 −91.138 1.00 57.66 S ATOM 10390 C CYS C 343 −40.445 36.900 −87.867 1.00 45.38 C ATOM 10391 O CYS C 343 −39.741 36.955 −86.855 1.00 43.57 O ATOM 10392 N GLY C 344 −41.765 37.076 −87.846 1.00 44.02 N ATOM 10393 CA GLY C 344 −42.484 37.366 −86.606 1.00 40.38 C ATOM 10394 C GLY C 344 −43.482 38.510 −86.673 1.00 36.50 C ATOM 10395 O GLY C 344 −43.802 39.008 −87.752 1.00 38.19 O ATOM 10396 N PRO C 345 −44.000 38.922 −85.511 1.00 33.82 N ATOM 10397 CA PRO C 345 −44.947 40.027 −85.425 1.00 33.17 C ATOM 10398 CB PRO C 345 −45.425 39.964 −83.974 1.00 32.76 C ATOM 10399 CG PRO C 345 −44.343 39.254 −83.242 1.00 34.07 C ATOM 10400 CD PRO C 345 −43.830 38.243 −84.216 1.00 34.07 C ATOM 10401 C PRO C 345 −44.317 41.386 −85.692 1.00 32.34 C ATOM 10402 O PRO C 345 −45.032 42.373 −85.824 1.00 30.68 O ATOM 10403 N MET C 346 −42.990 41.432 −85.766 1.00 32.93 N ATOM 10404 CA MET C 346 −42.282 42.700 −85.925 1.00 33.39 C ATOM 10405 CB MET C 346 −42.016 43.346 −84.566 1.00 32.96 C ATOM 10406 CG MET C 346 −41.696 44.824 −84.642 1.00 33.63 C ATOM 10407 SD MET C 346 −41.946 45.666 −83.069 1.00 34.92 S ATOM 10408 CE MET C 346 −40.604 44.977 −82.111 1.00 34.80 C ATOM 10409 C MET C 346 −40.986 42.586 −86.735 1.00 33.84 C ATOM 10410 O MET C 346 −40.181 41.663 −86.537 1.00 35.08 O ATOM 10411 N ALA C 347 −40.821 43.532 −87.663 1.00 32.32 N ATOM 10412 CA ALA C 347 −39.629 43.664 −88.497 1.00 29.12 C ATOM 10413 CB ALA C 347 −39.805 42.900 −89.798 1.00 28.73 C ATOM 10414 C ALA C 347 −39.416 45.142 −88.765 1.00 27.16 C ATOM 10415 O ALA C 347 −40.289 45.949 −88.481 1.00 26.54 O ATOM 10416 N ALA C 348 −38.249 45.503 −89.283 1.00 27.20 N ATOM 10417 CA ALA C 348 −37.982 46.895 −89.638 1.00 27.50 C ATOM 10418 CB ALA C 348 −36.568 47.296 −89.245 1.00 27.43 C ATOM 10419 C ALA C 348 −38.239 47.166 −91.127 1.00 27.44 C ATOM 10420 O ALA C 348 −37.817 46.399 −91.999 1.00 27.69 N ATOM 10421 N TYR C 349 −38.934 48.266 −91.399 1.00 27.16 N ATOM 10422 CA TYR C 349 −39.247 48.659 −92.757 1.00 27.05 C ATOM 10423 CB TYR C 349 −40.728 48.435 −93.023 1.00 27.71 C ATOM 10424 CG TYR C 349 −41.197 47.020 −92.752 1.00 28.88 C ATOM 10425 CD1 TYR C 349 −40.981 46.005 −93.689 1.00 28.96 C ATOM 10426 CE1 TYR C 349 −41.412 44.711 −93.454 1.00 28.30 C ATOM 10427 CZ TYR C 349 −42.078 44.412 −92.274 1.00 28.78 C ATOM 10428 OH TYR C 349 −42.499 43.113 −92.053 1.00 29.31 O ATOM 10429 CE2 TYR C 349 −42.316 45.402 −91.328 1.00 28.21 C ATOM 10430 CD2 TYR C 349 −41.874 46.696 −91.570 1.00 28.25 C ATOM 10431 C TYR C 349 −38.887 50.125 −92.975 1.00 26.87 C ATOM 10432 O TYR C 349 −39.060 50.944 −92.065 1.00 26.43 O ATOM 10433 N VAL C 350 −38.373 50.446 −94.168 1.00 26.11 N ATOM 10434 CA VAL C 350 −38.085 51.833 −94.546 1.00 26.68 C ATOM 10435 CB VAL C 350 −36.881 51.972 −95.510 1.00 27.48 C ATOM 10436 CG1 VAL C 350 −35.754 52.785 −94.894 1.00 27.76 C ATOM 10437 CG2 VAL C 350 −36.413 50.627 −96.037 1.00 28.18 C ATOM 10438 C VAL C 350 −39.250 52.461 −95.276 1.00 26.91 C ATOM 10439 O VAL C 350 −39.904 51.808 −96.086 1.00 26.80 O ATOM 10440 N ASN C 351 −39.484 53.744 −95.022 1.00 26.97 N ATOM 10441 CA ASN C 351 −40.415 54.501 −95.839 1.00 27.90 C ATOM 10442 CB ASN C 351 −41.217 55.490 −94.985 1.00 28.15 C ATOM 10443 CG ASN C 351 −40.381 56.640 −94.459 1.00 27.29 C ATOM 10444 OD1 ASN C 351 −39.291 56.938 −94.961 1.00 26.27 O ATOM 10445 ND2 ASN C 351 −40.901 57.301 −93.439 1.00 26.94 N ATOM 10446 C ASN C 351 −39.685 55.194 −96.988 1.00 29.01 C ATOM 10447 O ASN C 351 −38.474 55.025 −97.133 1.00 29.86 O ATOM 10448 N PRO C 352 −40.415 55.978 −97.810 1.00 29.88 N ATOM 10449 CA PRO C 352 −39.808 56.566 −99.000 1.00 30.10 C ATOM 10450 CB PRO C 352 −41.011 57.142 −99.749 1.00 29.21 C ATOM 10451 CG PRO C 352 −42.188 56.393 −99.218 1.00 28.50 C ATOM 10452 CD PRO C 352 −41.866 56.232 −97.777 1.00 29.02 C ATOM 10453 C PRO C 352 −38.772 57.661 −98.708 1.00 31.67 C ATOM 10454 O PRO C 352 −37.851 57.855 −99.503 1.00 32.87 O ATOM 10455 N HIS C 353 −38.918 58.369 −97.590 1.00 32.77 N ATOM 10456 CA HIS C 353 −37.946 59.404 −97.216 1.00 33.72 C ATOM 10457 CB HIS C 353 −38.599 60.537 −96.417 1.00 35.44 C ATOM 10458 CG HIS C 353 −39.852 61.106 −97.056 1.00 38.40 C ATOM 10459 ND1 HIS C 353 −40.058 61.104 −98.391 1.00 39.95 N ATOM 10460 CE1 HIS C 353 −41.250 61.680 −98.664 1.00 40.46 C ATOM 10461 NE2 HIS C 353 −41.804 62.064 −97.500 1.00 40.61 N ATOM 10462 CD2 HIS C 353 −40.970 61.725 −96.487 1.00 40.14 C ATOM 10463 C HIS C 353 −36.776 58.827 −96.463 1.00 33.50 C ATOM 10464 O HIS C 353 −35.946 59.565 −95.924 1.00 33.28 O ATOM 10465 N GLY C 354 −36.705 57.497 −96.415 1.00 33.28 N ATOM 10466 CA GLY C 354 −35.577 56.793 −95.810 1.00 33.10 C ATOM 10467 C GLY C 354 −35.653 56.577 −94.310 1.00 32.71 C ATOM 10468 O GLY C 354 −34.667 56.177 −93.696 1.00 31.57 O ATOM 10469 N TYR C 355 −36.823 56.831 −93.724 1.00 33.97 N ATOM 10470 CA TYR C 355 −37.036 56.667 −92.280 1.00 34.69 C ATOM 10471 CB TYR C 355 −38.036 57.715 −91.778 1.00 37.28 C ATOM 10472 CG TYR C 355 −38.183 57.728 −90.279 1.00 42.96 C ATOM 10473 CD1 TYR C 355 −38.981 56.775 −89.631 1.00 44.82 C ATOM 10474 CE1 TYR C 355 −39.114 56.763 −88.247 1.00 48.40 C ATOM 10475 CZ TYR C 355 −38.450 57.714 −87.484 1.00 50.11 C ATOM 10476 OH TYR C 355 −38.610 57.681 −86.112 1.00 52.38 O ATOM 10477 CE2 TYR C 355 −37.650 58.678 −88.100 1.00 48.33 C ATOM 10478 CD2 TYR C 355 −37.521 58.682 −89.492 1.00 45.58 C ATOM 10479 C TYR C 355 −37.467 55.224 −91.882 1.00 33.90 C ATOM 10480 O TYR C 355 −38.316 54.606 −92.537 1.00 35.81 O ATOM 10481 N VAL C 356 −36.888 54.697 −90.809 1.00 30.43 N ATOM 10482 CA VAL C 356 −37.075 53.293 −90.456 1.00 29.32 C ATOM 10483 CB VAL C 356 −35.741 52.688 −89.999 1.00 27.63 C ATOM 10484 CG1 VAL C 356 −35.947 51.361 −89.287 1.00 28.21 C ATOM 10485 CG2 VAL C 356 −34.822 52.516 −91.192 1.00 27.01 C ATOM 10486 C VAL C 356 −38.193 53.041 −89.415 1.00 31.40 C ATOM 10487 O VAL C 356 −38.264 53.723 −88.389 1.00 32.81 O ATOM 10488 N HIS C 357 −39.065 52.064 −89.688 1.00 32.30 N ATOM 10489 CA HIS C 357 −40.176 51.722 −88.774 1.00 32.20 C ATOM 10490 CB HIS C 357 −41.529 52.147 −89.346 1.00 32.68 C ATOM 10491 CG HIS C 357 −41.739 53.628 −89.386 1.00 32.55 C ATOM 10492 ND1 HIS C 357 −42.012 54.345 −88.288 1.00 32.45 N ATOM 10493 CE1 HIS C 357 −42.158 55.638 −88.623 1.00 33.55 C ATOM 10494 NE2 HIS C 357 −41.977 55.747 −89.948 1.00 33.97 N ATOM 10495 CD2 HIS C 357 −41.725 54.524 −90.451 1.00 33.08 C ATOM 10496 C HIS C 357 −40.248 50.259 −88.473 1.00 32.01 C ATOM 10497 O HIS C 357 −40.483 49.438 −89.365 1.00 31.26 O ATOM 10498 N GLU C 358 −40.076 49.923 −87.201 1.00 32.29 N ATOM 10499 CA GLU C 358 −40.326 48.569 −86.736 1.00 31.97 C ATOM 10500 CB GLU C 358 −39.530 48.279 −85.466 1.00 31.92 C ATOM 10501 CG GLU C 358 −38.069 48.660 −85.568 1.00 33.28 C ATOM 10502 CD GLU C 358 −37.276 48.182 −84.381 1.00 35.29 C ATOM 10503 OE1 GLU C 358 −36.868 47.002 −84.394 1.00 37.09 O ATOM 10504 OE2 GLU C 358 −37.055 48.982 −83.442 1.00 35.36 O ATOM 10505 C GLU C 358 −41.821 48.442 −86.480 1.00 31.24 C ATOM 10506 O GLU C 358 −42.326 48.874 −85.427 1.00 31.08 O ATOM 10507 N THR C 359 −42.545 47.895 −87.455 1.00 29.38 N ATOM 10508 CA THR C 359 −44.003 47.848 −87.334 1.00 28.07 C ATOM 10509 CB THR C 359 −44.752 48.381 −88.596 1.00 27.94 C ATOM 10510 OG1 THR C 359 −45.150 47.305 −89.442 1.00 28.73 O ATOM 10511 CG2 THR C 359 −43.872 49.324 −89.393 1.00 28.08 C ATOM 10512 C THR C 359 −44.468 46.467 −86.879 1.00 26.94 C ATOM 10513 O THR C 359 −43.905 45.442 −87.278 1.00 26.51 O ATOM 10514 N LEU C 360 −45.473 46.474 −86.004 1.00 25.71 N ATOM 10515 CA LEU C 360 −46.022 45.280 −85.379 1.00 24.53 C ATOM 10516 CB LEU C 360 −46.115 45.497 −83.862 1.00 24.04 C ATOM 10517 CG LEU C 360 −46.906 44.509 −82.999 1.00 23.67 C ATOM 10518 CD1 LEU C 360 −46.065 43.278 −82.707 1.00 24.04 C ATOM 10519 CD2 LEU C 360 −47.354 45.169 −81.705 1.00 23.41 C ATOM 10520 C LEU C 360 −47.404 44.984 −85.948 1.00 24.21 C ATOM 10521 O LEU C 360 −48.301 45.827 −85.870 1.00 24.41 O ATOM 10522 N THR C 361 −47.579 43.790 −86.514 1.00 23.92 N ATOM 10523 CA THR C 361 −48.870 43.397 −87.084 1.00 23.85 C ATOM 10524 CB THR C 361 −48.729 42.357 −88.212 1.00 23.69 C ATOM 10525 OG1 THR C 361 −47.794 41.344 −87.823 1.00 24.01 O ATOM 10526 CG2 THR C 361 −48.246 43.019 −89.485 1.00 24.12 C ATOM 10527 C THR C 361 −49.809 42.856 −86.022 1.00 24.06 C ATOM 10528 O THR C 361 −49.494 41.876 −85.340 1.00 23.84 O ATOM 10529 N VAL C 362 −50.959 43.510 −85.880 1.00 24.37 N ATOM 10530 CA VAL C 362 −52.024 43.017 −85.017 1.00 25.30 C ATOM 10531 CB VAL C 362 −52.234 43.910 −83.768 1.00 25.94 C ATOM 10532 CG1 VAL C 362 −51.020 43.856 −82.842 1.00 25.96 C ATOM 10533 CG2 VAL C 362 −52.584 45.342 −84.157 1.00 25.68 C ATOM 10534 C VAL C 362 −53.331 42.896 −85.788 1.00 25.90 C ATOM 10535 O VAL C 362 −53.508 43.563 −86.808 1.00 26.82 O ATOM 10536 N TYR C 363 −54.237 42.044 −85.302 1.00 27.09 N ATOM 10537 CA TYR C 363 −55.584 41.901 −85.881 1.00 28.27 C ATOM 10538 CB TYR C 363 −56.253 40.626 −85.390 1.00 29.21 C ATOM 10539 CG TYR C 363 −55.636 39.351 −85.887 1.00 30.08 C ATOM 10540 CD1 TYR C 363 −55.544 39.077 −87.254 1.00 30.49 C ATOM 10541 CE1 TYR C 363 −54.990 37.891 −87.710 1.00 31.12 C ATOM 10542 CZ TYR C 363 −54.539 36.951 −86.790 1.00 31.84 C ATOM 10543 OH TYR C 363 −53.991 35.764 −87.214 1.00 32.13 O ATOM 10544 CE2 TYR C 363 −54.633 37.198 −85.432 1.00 32.27 C ATOM 10545 CD2 TYR C 363 −55.182 38.392 −84.989 1.00 31.16 C ATOM 10546 C TYR C 363 −56.506 43.074 −85.564 1.00 28.66 C ATOM 10547 O TYR C 363 −57.041 43.701 −86.472 1.00 29.23 O ATOM 10548 N LYS C 364 −56.709 43.328 −84.270 1.00 29.45 N ATOM 10549 CA LYS C 364 −57.552 44.424 −83.771 1.00 30.16 C ATOM 10550 CB LYS C 364 −58.527 43.918 −82.693 1.00 31.84 C ATOM 10551 CG LYS C 364 −59.956 43.644 −83.144 1.00 32.80 C ATOM 10552 CD LYS C 364 −60.188 42.167 −83.445 1.00 33.71 C ATOM 10553 CE LYS C 364 −61.333 41.585 −82.619 1.00 34.51 C ATOM 10554 NZ LYS C 364 −62.535 42.470 −82.549 1.00 35.90 N ATOM 10555 C LYS C 364 −56.724 45.562 −83.166 1.00 29.61 C ATOM 10556 O LYS C 364 −55.652 45.337 −82.593 1.00 29.16 O ATOM 10557 N ALA C 365 −57.249 46.781 −83.287 1.00 28.84 N ATOM 10558 CA ALA C 365 −56.656 47.963 −82.673 1.00 27.41 C ATOM 10559 CB ALA C 365 −55.609 48.581 −83.584 1.00 27.30 C ATOM 10560 C ALA C 365 −57.735 48.978 −82.330 1.00 26.97 C ATOM 10561 O ALA C 365 −58.511 49.410 −83.190 1.00 26.92 O ATOM 10562 N SER C 366 −57.770 49.362 −81.065 1.00 26.43 N ATOM 10563 CA SER C 366 −58.808 50.240 −80.565 1.00 26.51 C ATOM 10564 CB SER C 366 −59.233 49.776 −79.173 1.00 27.33 C ATOM 10565 OG SER C 366 −59.448 48.373 −79.168 1.00 28.88 O ATOM 10566 C SER C 366 −58.372 51.707 −80.530 1.00 25.73 C ATOM 10567 O SER C 366 −57.177 52.012 −80.608 1.00 25.80 O ATOM 10568 N ASN C 367 −59.362 52.600 −80.420 1.00 24.57 N ATOM 10569 CA ASN C 367 −59.156 54.047 −80.238 1.00 23.02 C ATOM 10570 CB ASN C 367 −58.712 54.378 −78.802 1.00 22.99 C ATOM 10571 CG ASN C 367 −59.408 53.531 −77.763 1.00 22.84 C ATOM 10572 OD1 ASN C 367 −58.844 52.554 −77.276 1.00 23.01 O ATOM 10573 ND2 ASN C 367 −60.640 53.891 −77.426 1.00 22.29 N ATOM 10574 C ASN C 367 −58.178 54.677 −81.221 1.00 21.97 C ATOM 10575 O ASN C 367 −57.268 55.394 −80.813 1.00 22.08 O ATOM 10576 N LEU C 368 −58.359 54.404 −82.508 1.00 20.84 N ATOM 10577 CA LEU C 368 −57.565 55.069 −83.541 1.00 19.91 C ATOM 10578 CB LEU C 368 −56.617 54.078 −84.236 1.00 19.47 C ATOM 10579 CG LEU C 368 −55.562 53.382 −83.359 1.00 19.30 C ATOM 10580 CD1 LEU C 368 −54.953 52.201 −84.087 1.00 18.97 C ATOM 10581 CD2 LEU C 368 −56.473 54.329 −82.877 1.00 18.79 C ATOM 10582 C LEU C 368 −58.447 55.797 −84.555 1.00 19.53 C ATOM 10583 O LEU C 368 −59.595 55.421 −84.786 1.00 19.57 O ATOM 10584 N ASN C 369 −57.909 56.858 −85.139 1.00 19.40 N ATOM 10585 CA ASN C 369 −58.584 57.555 −86.226 1.00 19.63 C ATOM 10586 CB ASN C 369 −58.770 59.031 −85.894 1.00 19.34 C ATOM 10587 CG ASN C 369 −59.623 59.246 −84.676 1.00 19.08 C ATOM 10588 OD1 ASN C 369 −60.677 58.625 −84.518 1.00 18.93 O ATOM 10589 ND2 ASN C 369 −59.179 60.142 −83.805 1.00 19.48 N ATOM 10590 C ASN C 369 −57.789 57.427 −87.505 1.00 19.56 C ATOM 10591 O ASN C 369 −56.556 57.409 −87.465 1.00 19.77 O ATOM 10592 N LEU C 370 −58.497 57.348 −88.631 1.00 19.37 N ATOM 10593 CA LEU C 370 −57.866 57.153 −89.935 1.00 19.79 C ATOM 10594 CB LEU C 370 −58.388 55.868 −90.588 1.00 18.90 C ATOM 10595 CG LEU C 370 −58.449 54.639 −89.660 1.00 18.33 C ATOM 10596 CD1 LEU C 370 −59.367 53.550 −90.204 1.00 17.58 C ATOM 10597 CD2 LEU C 370 −57.059 54.091 −89.351 1.00 17.97 C ATOM 10598 C LEU C 370 −58.071 58.372 −90.845 1.00 20.82 C ATOM 10599 O LEU C 370 −59.199 58.847 −91.015 1.00 20.66 O ATOM 10600 N ILE C 371 −56.971 58.896 −91.387 1.00 22.07 N ATOM 10601 CA ILE C 371 −57.014 60.082 −92.252 1.00 24.28 C ATOM 10602 CB ILE C 371 −56.358 61.340 −91.596 1.00 25.12 C ATOM 10603 CG1 ILE C 371 −54.863 61.122 −91.306 1.00 25.59 C ATOM 10604 CD1 ILE C 371 −53.936 61.577 −92.418 1.00 25.85 C ATOM 10605 CG2 ILE C 371 −57.117 61.783 −90.342 1.00 24.41 C ATOM 10606 C ILE C 371 −56.386 59.804 −93.620 1.00 25.93 C ATOM 10607 O ILE C 371 −55.495 58.955 −93.747 1.00 27.08 O ATOM 10608 N GLY C 372 −56.847 60.519 −94.642 1.00 26.96 N ATOM 10609 CA GLY C 372 −56.378 60.277 −96.004 1.00 28.86 C ATOM 10610 C GLY C 372 −56.985 59.028 −96.627 1.00 30.00 C ATOM 10611 O GLY C 372 −57.900 58.415 −96.059 1.00 29.29 O ATOM 10612 N ARG C 373 −56.456 58.648 −97.791 1.00 31.35 N ATOM 10613 CA ARG C 373 −57.042 57.604 −98.620 1.00 32.80 C ATOM 10614 CB ARG C 373 −57.135 58.106 −100.058 1.00 36.06 C ATOM 10615 CG ARG C 373 −58.443 57.802 −100.768 1.00 39.89 C ATOM 10616 CD ARG C 373 −58.316 58.066 −102.268 1.00 42.07 C ATOM 10617 NE ARG C 373 −57.800 56.895 −102.985 1.00 44.79 N ATOM 10618 CZ ARG C 373 −58.521 56.127 −103.804 1.00 45.67 C ATOM 10619 NH1 ARG C 373 −57.957 55.077 −104.395 1.00 44.79 N ATOM 10620 NH2 ARG C 373 −59.802 56.407 −104.044 1.00 45.23 N ATOM 10621 C ARG C 373 −56.158 56.364 −98.572 1.00 32.66 C ATOM 10622 O ARG C 373 −54.927 56.486 −98.611 1.00 32.01 O ATOM 10623 N PRO C 374 −56.772 55.159 −98.477 1.00 32.71 N ATOM 10624 CA PRO C 374 −55.966 53.925 −98.497 1.00 32.13 C ATOM 10625 CB PRO C 374 −57.022 52.812 −98.515 1.00 31.20 C ATOM 10626 CG PRO C 374 −58.195 53.420 −97.820 1.00 30.94 C ATOM 10627 CD PRO C 374 −58.201 54.871 −98.241 1.00 31.76 C ATOM 10628 C PRO C 374 −55.070 53.866 −99.737 1.00 32.34 C ATOM 10629 O PRO C 374 −55.530 54.143 −100.849 1.00 32.78 O ATOM 10630 N SER C 375 −53.797 53.542 −99.527 1.00 31.71 N ATOM 10631 CA SER C 375 −52.791 53.601 −100.582 1.00 30.15 C ATOM 10632 CB SER C 375 −51.961 54.874 −100.429 1.00 30.26 C ATOM 10633 OG SER C 375 −50.830 54.862 −101.281 1.00 30.88 O ATOM 10634 C SER C 375 −51.883 52.370 −100.556 1.00 29.43 C ATOM 10635 O SER C 375 −51.508 51.899 −99.488 1.00 28.84 O ATOM 10636 N THR C 376 −51.546 51.856 −101.739 1.00 28.48 N ATOM 10637 CA THR C 376 −50.613 50.736 −101.881 1.00 27.27 C ATOM 10638 CB THR C 376 −51.040 49.798 −103.014 1.00 24.95 C ATOM 10639 OG1 THR C 376 −51.017 50.522 −104.238 1.00 23.33 O ATOM 10640 CG2 THR C 376 −52.424 49.274 −102.780 1.00 23.82 C ATOM 10641 C THR C 376 −49.201 51.247 −102.184 1.00 28.37 C ATOM 10642 O THR C 376 −48.225 50.485 −102.163 1.00 28.70 O ATOM 10643 N GLU C 377 −49.114 52.540 −102.481 1.00 29.94 N ATOM 10644 CA GLU C 377 −47.854 53.234 −102.735 1.00 31.69 C ATOM 10645 CB GLU C 377 −48.126 54.737 −102.774 1.00 33.99 C ATOM 10646 CG GLU C 377 −47.120 55.566 −103.541 1.00 38.01 C ATOM 10647 CD GLU C 377 −47.642 56.967 −103.878 1.00 43.36 C ATOM 10648 OE1 GLU C 377 −48.866 57.122 −104.150 1.00 45.65 O ATOM 10649 OE2 GLU C 377 −46.819 57.920 −103.887 1.00 45.18 O ATOM 10650 C GLU C 377 −46.786 52.907 −101.676 1.00 31.03 C ATOM 10651 O GLU C 377 −46.911 53.288 −100.515 1.00 30.52 O ATOM 10652 N HIS C 378 −45.754 52.175 −102.090 1.00 30.76 N ATOM 10653 CA HIS C 378 −44.604 51.856 −101.238 1.00 30.21 C ATOM 10654 CB HIS C 378 −43.903 53.144 −100.774 1.00 31.11 C ATOM 10655 CG HIS C 378 −42.454 52.955 −100.362 1.00 31.85 C ATOM 10656 ND1 HIS C 378 −42.066 52.919 −99.074 1.00 32.07 N ATOM 10657 CE1 HIS C 378 −40.727 52.758 −99.011 1.00 31.67 C ATOM 10658 NE2 HIS C 378 −40.256 52.695 −100.266 1.00 31.92 N ATOM 10659 CD2 HIS C 378 −41.291 52.815 −101.125 1.00 32.55 C ATOM 10660 C HIS C 378 −45.000 51.001 −100.067 1.00 29.68 C ATOM 10661 O HIS C 378 −44.337 51.017 −99.032 1.00 31.57 O ATOM 10662 N SER C 379 −46.079 50.235 −100.220 1.00 28.49 N ATOM 10663 CA SER C 379 −46.575 49.371 −99.135 1.00 27.29 C ATOM 10664 CB SER C 379 −47.971 48.838 −99.447 1.00 26.54 C ATOM 10665 OG SER C 379 −48.225 47.660 −98.708 1.00 25.40 O ATOM 10666 C SER C 379 −45.656 48.197 −98.817 1.00 26.95 C ATOM 10667 O SER C 379 −45.233 47.462 −99.711 1.00 28.52 O ATOM 10668 N TRP C 380 −45.385 48.010 −97.532 1.00 25.98 N ATOM 10669 CA TRP C 380 −44.525 46.928 −97.060 1.00 25.57 C ATOM 10670 CB TRP C 380 −44.028 47.230 −95.642 1.00 25.56 C ATOM 10671 CG TRP C 380 −43.357 48.583 −95.532 1.00 25.28 C ATOM 10672 CD1 TRP C 380 −42.506 49.182 −96.451 1.00 25.01 C ATOM 10673 NE1 TRP C 380 −42.107 50.412 −96.017 1.00 24.70 N ATOM 10674 CE2 TRP C 380 −42.642 50.692 −94.821 1.00 24.72 C ATOM 10675 CD2 TRP C 380 −43.471 49.550 −94.443 1.00 25.05 C ATOM 10676 CE3 TRP C 380 −44.153 49.586 −93.239 1.00 25.17 C ATOM 10677 CZ3 TRP C 380 −44.012 50.716 −92.431 1.00 25.22 C ATOM 10678 CH2 TRP C 380 −43.205 51.796 −92.810 1.00 25.01 C ATOM 10679 CZ2 TRP C 380 −42.511 51.803 −94.016 1.00 24.76 C ATOM 10680 C TRP C 380 −45.185 45.579 −97.114 1.00 25.27 C ATOM 10681 O TRP C 380 −44.546 44.561 −96.872 1.00 24.64 O ATOM 10682 N PHE C 381 −46.474 45.558 −97.433 1.00 26.22 N ATOM 10683 CA PHE C 381 −47.229 44.307 −97.527 1.00 26.50 C ATOM 10684 CB PHE C 381 −48.246 44.199 −96.387 1.00 25.82 C ATOM 10685 CG PHE C 381 −47.628 44.285 −95.025 1.00 26.00 C ATOM 10686 CD1 PHE C 381 −46.986 43.182 −94.465 1.00 26.58 C ATOM 10687 CE1 PHE C 381 −46.400 43.260 −93.216 1.00 26.43 C ATOM 10688 CZ PHE C 381 −46.448 44.452 −92.511 1.00 26.23 C ATOM 10689 CE2 PHE C 381 −47.081 45.555 −93.062 1.00 26.05 C ATOM 10690 CD2 PHE C 381 −47.665 45.468 −94.311 1.00 25.88 C ATOM 10691 C PHE C 381 −47.928 44.198 −98.875 1.00 26.97 C ATOM 10692 O PHE C 381 −49.091 44.585 −98.995 1.00 27.72 O ATOM 10693 N PRO C 382 −47.218 43.675 −99.899 1.00 27.09 N ATOM 10694 CA PRO C 382 −47.826 43.553 −101.227 1.00 26.40 C ATOM 10695 CB PRO C 382 −46.841 42.669 −102.005 1.00 26.79 C ATOM 10696 CG PRO C 382 −45.557 42.755 −101.257 1.00 27.82 C ATOM 10697 CD PRO C 382 −45.900 43.014 −99.820 1.00 27.53 C ATOM 10698 C PRO C 382 −49.168 42.861 −101.105 1.00 26.11 C ATOM 10699 O PRO C 382 −49.261 41.767 −100.531 1.00 25.37 O ATOM 10700 N GLY C 383 −50.205 43.521 −101.610 1.00 26.70 N ATOM 10701 CA GLY C 383 −51.568 43.020 −101.507 1.00 26.64 C ATOM 10702 C GLY C 383 −52.434 43.924 −100.666 1.00 26.98 C ATOM 10703 O GLY C 383 −53.661 43.924 −100.811 1.00 28.25 O ATOM 10704 N TYR C 384 −51.789 44.710 −99.799 1.00 27.12 N ATOM 10705 CA TYR C 384 −52.484 45.613 −98.878 1.00 26.44 C ATOM 10706 CB TYR C 384 −52.121 45.265 −97.431 1.00 26.85 C ATOM 10707 CG TYR C 384 −52.609 43.890 −97.040 1.00 27.90 C ATOM 10708 CD1 TYR C 384 −53.934 43.686 −96.667 1.00 28.21 C ATOM 10709 CE1 TYR C 384 −54.401 42.431 −96.333 1.00 28.83 C ATOM 10710 CZ TYR C 384 −53.538 41.350 −96.371 1.00 29.60 C ATOM 10711 OH TYR C 384 −54.008 40.103 −96.034 1.00 30.66 O ATOM 10712 CE2 TYR C 384 −52.212 41.517 −96.741 1.00 29.10 C ATOM 10713 CD2 TYR C 384 −51.757 42.783 −97.082 1.00 28.57 C ATOM 10714 C TYR C 384 −52.261 47.101 −99.165 1.00 25.94 C ATOM 10715 O TYR C 384 −51.221 47.492 −99.710 1.00 26.36 O ATOM 10716 N ALA C 385 −53.264 47.913 −98.830 1.00 25.24 N ATOM 10717 CA ALA C 385 −53.145 49.374 −98.836 1.00 24.98 C ATOM 10718 CB ALA C 385 −54.306 50.005 −99.584 1.00 24.99 C ATOM 10719 C ALA C 385 −53.082 49.918 −97.407 1.00 24.92 C ATOM 10720 O ALA C 385 −53.767 49.410 −96.512 1.00 24.46 O ATOM 10721 N TRP C 386 −52.269 50.961 −97.208 1.00 25.24 N ATOM 10722 CA TRP C 386 −52.079 51.587 −95.886 1.00 24.58 C ATOM 10723 CB TRP C 386 −50.593 51.738 −95.548 1.00 24.60 C ATOM 10724 CG TRP C 386 −49.804 52.456 −96.605 1.00 25.04 C ATOM 10725 CD1 TRP C 386 −49.049 51.890 −97.616 1.00 25.20 C ATOM 10726 NE1 TRP C 386 −48.478 52.862 −98.399 1.00 25.72 N ATOM 10727 CE2 TRP C 386 −48.817 54.097 −97.961 1.00 25.52 C ATOM 10728 CD2 TRP C 386 −49.673 53.915 −96.797 1.0 25.69 C ATOM 10729 CE3 TRP C 386 −50.158 55.047 −96.131 1.00 25.67 C ATOM 10730 CZ3 TRP C 386 −49.813 56.312 −96.620 1.00 24.69 C ATOM 10731 CH2 TRP C 386 −48.987 56.463 −97.738 1.00 25.02 C ATOM 10732 CZ2 TRP C 386 −48.472 55.358 −98.431 1.00 25.62 C ATOM 10733 C TRP C 386 −52.804 52.902 −95.719 1.00 24.02 C ATOM 10734 O TRP C 386 −52.861 53.736 −96.640 1.00 23.62 O ATOM 10735 N THR C 387 −53.397 53.074 −94.539 1.00 23.40 N ATOM 10736 CA THR C 387 −54.011 54.339 −94.147 1.00 23.26 C ATOM 10737 CB THR C 387 −55.552 54.258 −94.007 1.00 23.30 C ATOM 10738 OG1 THR C 387 −56.131 53.665 −95.178 1.00 23.65 O ATOM 10739 CG2 THR C 387 −56.149 55.644 −93.808 1.00 23.15 C ATOM 10740 C THR C 387 −53.422 54.717 −92.808 1.00 22.72 C ATOM 10741 O THR C 387 −53.299 53.873 −91.915 1.00 22.46 O ATOM 10742 N VAL C 388 −53.047 55.987 −92.690 1.00 22.21 N ATOM 10743 CA VAL C 388 −52.463 56.528 −91.475 1.00 21.65 C ATOM 10744 CB VAL C 388 −51.947 57.972 −91.713 1.00 21.69 C ATOM 10745 CG1 VAL C 388 −51.613 58.682 −90.409 1.00 21.73 C ATOM 10746 CG2 VAL C 388 −50.731 57.952 −92.635 1.00 21.77 C ATOM 10747 C VAL C 388 −53.497 56.456 −90.347 1.00 21.44 C ATOM 10748 O VAL C 388 −54.672 56.763 −90.552 1.00 21.51 O ATOM 10749 N ALA C 389 −53.054 56.001 −89.179 1.00 20.82 N ATOM 10750 CA ALA C 389 −53.901 55.892 −88.007 1.00 20.61 C ATOM 10751 CB ALA C 389 −53.967 54.442 −87.557 1.00 20.77 C ATOM 10752 C ALA C 389 −53.276 56.742 −86.922 1.00 20.96 C ATOM 10753 O ALA C 389 −52.043 56.786 −86.839 1.00 21.40 O ATOM 10754 N GLN C 390 −54.092 57.397 −86.081 1.00 20.76 N ATOM 10755 CA GLN C 390 −53.524 58.115 −84.917 1.00 20.94 C ATOM 10756 CB GLN C 390 −53.147 59.550 −85.293 1.00 20.81 C ATOM 10757 CG GLN C 390 −54.302 60.435 −85.708 1.00 21.03 C ATOM 10758 CD GLN C 390 −53.903 61.417 −86.795 1.00 20.90 C ATOM 10759 OE1 GLN C 390 −53.188 61.062 −87.727 1.00 20.56 O ATOM 10760 NE2 GLN C 390 −54.369 62.654 −86.681 1.00 20.73 N ATOM 10761 C GLN C 390 −54.281 58.073 −83.571 1.00 21.07 C ATOM 10762 O GLN C 390 −55.494 57.898 −83.544 1.00 21.22 O ATOM 10763 N CYS C 391 −53.529 58.283 −82.493 1.00 21.48 N ATOM 10764 CA CYS C 391 −54.071 58.341 −81.142 1.00 21.88 C ATOM 10765 CB CYS C 391 −52.994 58.798 −80.155 1.00 23.62 C ATOM 10766 SG CYS C 391 −53.251 58.235 −78.456 1.00 24.16 S ATOM 10767 C CYS C 391 −55.283 59.259 −81.052 1.00 21.54 C ATOM 10768 O CYS C 391 −55.161 60.484 −81.033 1.00 21.45 O ATOM 10769 N LYS C 392 −56.453 58.638 −80.995 1.00 21.02 N ATOM 10770 CA LYS C 392 −57.739 59.335 −80.860 1.00 20.07 C ATOM 10771 CB LYS C 392 −58.810 58.309 −80.452 1.00 20.00 C ATOM 10772 CG LYS C 392 −60.146 58.873 −79.999 1.00 20.67 C ATOM 10773 CD LYS C 392 −60.707 58.099 −78.804 1.00 21.00 C ATOM 10774 CE LYS C 392 −61.403 56.808 −79.222 1.00 20.98 C ATOM 10775 NZ LYS C 392 −61.934 56.071 −78.048 1.00 20.32 N ATOM 10776 C LYS C 392 −57.696 60.527 −79.868 1.00 19.59 C ATOM 10777 O LYS C 392 −58.312 61.564 −80.116 1.00 19.54 O ATOM 10778 N ILE C 393 −56.969 60.368 −78.759 1.00 18.72 N ATOM 10779 CA ILE C 393 −56.805 61.425 −77.757 1.00 18.31 C ATOM 10780 CB ILE C 393 −56.440 60.841 −76.359 1.00 17.23 C ATOM 10781 CG1 ILE C 393 −57.417 59.738 −75.914 1.00 16.62 C ATOM 10782 CD1 ILE C 393 −58.888 60.078 −76.034 1.00 16.59 C ATOM 10783 CG2 ILE C 393 −56.297 61.941 −75.315 1.00 16.87 C ATOM 10784 C ILE C 393 −55.685 62.362 −78.197 1.00 19.08 C ATOM 10785 O ILE C 393 −55.843 63.574 −78.244 1.00 19.38 O ATOM 10786 N CYS C 394 −54.520 61.818 −78.533 1.00 20.70 N ATOM 10787 CA CYS C 394 −53.347 62.673 −78.770 1.00 21.35 C ATOM 10788 CB CYS C 394 −52.188 62.275 −77.839 1.00 22.80 C ATOM 10789 SG CYS C 394 −50.953 61.146 −78.509 1.00 23.92 S ATOM 10790 C CYS C 394 −52.857 62.892 −80.220 1.00 21.21 C ATOM 10791 O CYS C 394 −51.894 63.630 −80.432 1.00 21.16 O ATOM 10792 N ALA C 395 −53.505 62.287 −81.216 1.00 20.74 N ATOM 10793 CA ALA C 395 −53.177 62.630 −82.596 1.00 20.39 C ATOM 10794 CB ALA C 395 −53.272 64.130 −82.838 1.00 20.57 C ATOM 10795 C ALA C 395 −51.787 62.099 −82.932 1.00 19.77 C ATOM 10796 O ALA C 395 −51.366 62.147 −84.087 1.00 19.25 O ATOM 10797 N SER C 396 −51.097 61.596 −81.914 1.00 19.91 N ATOM 10798 CA SER C 396 −49.774 61.009 −82.077 1.00 20.17 C ATOM 10799 CB SER C 396 −49.218 60.548 −80.724 1.00 20.10 C ATOM 10800 OG SER C 396 −48.308 59.474 −80.860 1.00 20.63 O ATOM 10801 C SER C 396 −49.856 59.845 −83.043 1.00 20.44 C ATOM 10802 O SER C 396 −50.426 58.808 −82.731 1.00 21.13 O ATOM 10803 N HIS C 397 −49.275 60.031 −84.218 1.00 20.97 N ATOM 10804 CA HIS C 397 −49.300 59.035 −85.262 1.00 21.61 C ATOM 10805 CB HIS C 397 −48.510 59.544 −86.462 1.00 22.55 C ATOM 10806 CG HIS C 397 −48.269 58.501 −87.506 1.00 23.83 C ATOM 10807 ND1 HIS C 397 −47.035 58.102 −87.852 1.00 24.43 N ATOM 10808 CE1 HIS C 397 −47.129 57.135 −88.779 1.00 25.57 C ATOM 10809 NE2 HIS C 397 −48.436 56.912 −89.021 1.00 25.65 N ATOM 10810 CD2 HIS C 397 −49.162 57.729 −88.249 1.00 24.44 C ATOM 10811 C HIS C 397 −48.795 57.683 −84.769 1.00 22.20 C ATOM 10812 O HIS C 397 −47.591 57.487 −84.549 1.00 22.16 O ATOM 10813 N ILE C 398 −49.727 56.742 −84.591 1.00 22.21 N ATOM 10814 CA ILE C 398 −49.447 55.449 −83.944 1.00 21.94 C ATOM 10815 CB ILE C 398 −50.674 54.960 −83.118 1.00 21.28 C ATOM 10816 CG1 ILE C 398 −50.987 55.913 −81.947 1.00 21.45 C ATOM 10817 CD1 ILE C 398 −49.957 55.979 −80.839 1.00 21.66 C ATOM 10818 CG2 ILE C 398 −50.510 53.525 −82.638 1.00 20.78 C ATOM 10819 C ILE C 398 −49.026 54.359 −84.942 1.00 22.75 C ATOM 10820 O ILE C 398 −48.460 53.342 −84.545 1.00 23.32 O ATOM 10821 N GLY C 399 −49.305 54.560 −86.231 1.00 22.76 N ATOM 10822 CA GLY C 399 −49.054 53.510 −87.222 1.00 22.66 C ATOM 10823 C GLY C 399 −49.995 53.551 −88.411 1.00 23.04 C ATOM 10824 O GLY C 399 −50.291 54.629 −88.941 1.00 23.19 O ATOM 10825 N TRP C 400 −50.459 52.373 −88.836 1.00 23.20 N ATOM 10826 CA TRP C 400 −51.282 52.238 −90.050 1.00 23.42 C ATOM 10827 CB TRP C 400 −50.400 52.022 −91.291 1.00 23.86 C ATOM 10828 CG TRP C 400 −49.297 53.040 −91.465 1.00 23.58 C ATOM 10829 CD1 TRP C 400 −49.366 54.267 −92.119 1.00 23.51 C ATOM 10830 NE1 TRP C 400 −48.162 54.916 −92.066 1.00 23.68 N ATOM 10831 CE2 TRP C 400 −47.255 54.181 −91.388 1.00 23.56 C ATOM 10832 CD2 TRP C 400 −47.925 52.944 −90.976 1.00 23.38 C ATOM 10833 CE3 TRP C 400 −47.209 51.995 −90.261 1.00 23.30 C ATOM 10834 CZ3 TRP C 400 −45.870 52.259 −89.962 1.00 23.92 C ATOM 10835 CH2 TRP C 400 −45.242 53.451 −90.375 1.00 23.81 C ATOM 10836 CZ2 TRP C 400 −45.926 54.433 −91.090 1.00 23.62 C ATOM 10837 C TRP C 400 −52.273 51.111 −89.988 1.00 23.35 C ATOM 10838 O TRP C 400 −51.991 50.047 −89.417 1.00 22.27 O ATOM 10839 N LYS C 401 −53.435 51.335 −90.604 1.00 23.79 N ATOM 10840 CA LYS C 401 −54.363 50.252 −90.937 1.00 24.46 C ATOM 10841 CB LYS C 401 −55.816 50.688 −90.780 1.00 24.09 C ATOM 10842 CG LYS C 401 −56.803 49.611 −91.196 1.00 23.23 C ATOM 10843 CD LYS C 401 −58.244 50.012 −90.948 1.00 22.72 C ATOM 10844 CE LYS C 401 −59.140 48.794 −91.043 1.00 22.41 C ATOM 10845 NZ LYS C 401 −60.526 49.070 −90.600 1.00 22.50 N ATOM 10846 C LYS C 401 −54.137 49.777 −92.368 1.00 25.20 C ATOM 10847 O LYS C 401 −54.076 50.579 −93.306 1.00 24.71 O ATOM 10848 N PHE C 402 −54.015 48.466 −92.527 1.00 26.71 N ATOM 10849 CA PHE C 402 −53.828 47.878 −93.844 1.00 27.68 C ATOM 10850 CB PHE C 402 −52.655 46.896 −93.855 1.00 28.40 C ATOM 10851 CG PHE C 402 −51.303 47.552 −93.753 1.00 29.07 C ATOM 10852 CD2 PHE C 402 −50.578 47.866 −94.902 1.00 29.82 C ATOM 10853 CE2 PHE C 402 −49.323 48.460 −94.810 1.00 29.71 C ATOM 10854 CZ PHE C 402 −48.780 48.748 −93.565 1.00 29.24 C ATOM 10855 CE1 PHE C 402 −49.490 48.438 −92.413 1.00 28.84 C ATOM 10856 CD1 PHE C 402 −50.741 47.841 −92.510 1.00 28.82 C ATOM 10857 C PHE C 402 −55.101 47.168 −94.251 1.00 27.64 C ATOM 10858 O PHE C 402 −55.692 46.433 −93.459 1.00 27.81 O ATOM 10859 N THR C 403 −55.527 47.411 −95.484 1.00 27.40 N ATOM 10860 CA THR C 403 −56.710 46.771 −96.026 1.00 27.27 C ATOM 10861 CB THR C 403 −57.783 47.805 −96.394 1.00 26.67 C ATOM 10862 OG1 THR C 403 −57.175 48.886 −97.109 1.00 26.59 O ATOM 10863 CG2 THR C 403 −58.445 48.342 −95.144 1.00 25.92 C ATOM 10864 C THR C 403 −56.321 45.994 −97.265 1.00 27.96 C ATOM 10865 O THR C 403 −55.388 46.375 −97.970 1.00 28.37 O ATOM 10866 N ALA C 404 −57.022 44.890 −97.515 1.00 28.74 N ATOM 10867 CA ALA C 404 −56.804 44.091 −98.709 1.00 28.90 C ATOM 10868 CB ALA C 404 −57.426 42.722 −98.534 1.00 28.84 C ATOM 10869 C ALA C 404 −57.387 44.791 −99.934 1.00 30.60 C ATOM 10870 O ALA C 404 −58.324 45.606 −99.820 1.00 29.71 O ATOM 10871 N THR C 405 −56.808 44.490 −101.098 1.00 32.77 N ATOM 10872 CA THR C 405 −57.319 44.975 −102.392 1.00 34.13 C ATOM 10873 CB THR C 405 −56.211 45.638 −103.241 1.00 32.82 C ATOM 10874 OG1 THR C 405 −54.926 45.276 −102.721 1.00 30.39 O ATOM 10875 CG2 THR C 405 −56.355 47.171 −103.222 1.00 32.92 C ATOM 10876 C THR C 405 −58.009 43.861 −103.193 1.00 35.64 C ATOM 10877 O THR C 405 −58.655 44.121 −104.203 1.00 35.44 O ATOM 10878 N LYS C 406 −57.864 42.626 −102.723 1.00 38.71 N ATOM 10879 CA LYS C 406 −58.526 41.477 −103.326 1.00 43.17 C ATOM 10880 CB LYS C 406 −57.499 40.407 −103.723 1.00 47.20 C ATOM 10881 CG LYS C 406 −56.657 40.703 −104.961 1.00 48.72 C ATOM 10882 CD LYS C 406 −55.541 39.668 −105.101 1.00 49.63 C ATOM 10883 CE LYS C 406 −54.635 39.945 −106.293 1.00 50.26 C ATOM 10884 NZ LYS C 406 −55.316 39.665 −107.589 1.00 50.93 N ATOM 10885 C LYS C 406 −59.527 40.875 −102.340 1.00 44.23 C ATOM 10886 O LYS C 406 −59.270 40.828 −101.133 1.00 44.55 O ATOM 10887 N LYS C 407 −60.658 40.404 −102.863 1.00 45.17 N ATOM 10888 CA LYS C 407 −61.727 39.848 −102.036 1.00 45.67 C ATOM 10889 CB LYS C 407 −63.088 40.024 −102.728 1.00 47.68 C ATOM 10890 CG LYS C 407 −63.931 41.185 −102.199 1.00 49.68 C ATOM 10891 CD LYS C 407 −64.295 41.019 −100.719 1.00 51.04 C ATOM 10892 CE LYS C 407 −65.264 39.861 −100.481 1.00 51.28 C ATOM 10893 NZ LYS C 407 −65.171 39.333 −99.090 1.00 50.49 N ATOM 10894 C LYS C 407 −61.500 38.381 −101.664 1.00 45.25 C ATOM 10895 O LYS C 407 −62.369 37.742 −101.071 1.00 44.78 O ATOM 10896 N ASP C 408 −60.326 37.861 −102.006 1.00 45.55 N ATOM 10897 CA ASP C 408 −60.000 36.452 −101.789 1.00 46.17 C ATOM 10898 CB ASP C 408 −59.590 35.799 −103.117 1.00 47.92 C ATOM 10899 CG ASP C 408 −58.441 36.542 −103.811 1.00 50.72 C ATOM 10900 OD1 ASP C 408 −58.569 37.767 −104.043 1.00 49.75 O ATOM 10901 OD2 ASP C 408 −57.410 35.901 −104.127 1.00 51.05 O ATOM 10902 C ASP C 408 −58.885 36.294 −100.754 1.00 45.25 C ATOM 10903 O ASP C 408 −58.552 35.184 −100.353 1.00 44.45 O ATOM 10904 N MET C 409 −58.317 37.420 −100.332 1.00 46.02 N ATOM 10905 CA MET C 409 −57.178 37.446 −99.418 1.00 45.36 C ATOM 10906 CB MET C 409 −56.454 38.782 −99.541 1.00 44.14 C ATOM 10907 CG MET C 409 −55.603 38.905 −100.783 1.00 44.40 C ATOM 10908 SD MET C 409 −54.746 40.485 −100.854 1.00 45.71 S ATOM 10909 CE MET C 409 −53.161 39.955 −101.511 1.00 44.45 C ATOM 10910 C MET C 409 −57.618 37.274 −97.978 1.00 46.56 C ATOM 10911 O MET C 409 −58.655 37.815 −97.574 1.00 47.61 O ATOM 10912 N SER C 410 −56.826 36.541 −97.195 1.00 45.59 N ATOM 10913 CA SER C 410 −57.057 36.479 −95.748 1.00 43.55 C ATOM 10914 CB SER C 410 −56.977 35.056 −95.221 1.00 42.41 C ATOM 10915 OG SER C 410 −57.771 34.940 −94.058 1.00 43.14 O ATOM 10916 C SER C 410 −56.134 37.441 −94.983 1.00 43.24 C ATOM 10917 O SER C 410 −55.052 37.784 −95.476 1.00 42.29 O ATOM 10918 N PRO C 411 −56.494 37.759 −93.721 1.00 42.22 N ATOM 10919 CA PRO C 411 −56.727 39.095 −93.201 1.00 39.59 C ATOM 10920 CB PRO C 411 −55.355 39.482 −92.646 1.00 39.42 C ATOM 10921 CG PRO C 411 −54.715 38.164 −92.294 1.00 40.84 C ATOM 10922 CD PRO C 411 −55.638 37.051 −92.764 1.00 42.23 C ATOM 10923 C PRO C 411 −57.235 40.087 −94.251 1.00 38.13 C ATOM 10924 O PRO C 411 −56.478 40.515 −95.124 1.00 38.17 O ATOM 10925 N GLN C 412 −58.520 40.432 −94.174 1.00 36.11 N ATOM 10926 CA GLN C 412 −59.075 41.491 −95.022 1.00 34.08 C ATOM 10927 CB GLN C 412 −60.604 41.394 −95.115 1.00 32.51 C ATOM 10928 CG GLN C 412 −61.083 40.457 −96.221 1.00 32.05 C ATOM 10929 CD GLN C 412 −60.680 40.918 −97.628 1.00 31.67 C ATOM 10930 OE1 GLN C 412 −61.300 41.817 −98.205 1.00 30.90 O ATOM 10931 NE2 GLN C 412 −59.649 40.282 −98.193 1.00 30.63 N ATOM 10932 C GLN C 412 −58.607 42.872 −94.553 1.00 33.05 C ATOM 10933 O GLN C 412 −58.502 43.816 −95.343 1.00 32.50 O ATOM 10934 N LYS C 413 −58.318 42.967 −93.259 1.00 32.05 N ATOM 10935 CA LYS C 413 −57.598 44.099 −92.690 1.00 30.72 C ATOM 10936 CB LYS C 413 −58.562 45.214 −92.262 1.00 29.67 C ATOM 10937 CG LYS C 413 −59.205 45.037 −90.894 1.00 29.94 C ATOM 10938 CD LYS C 413 −60.456 44.178 −90.956 1.00 31.98 C ATOM 10939 CE LYS C 413 −60.160 42.721 −90.619 1.00 33.11 C ATOM 10940 NZ LYS C 413 −61.178 41.794 −91.194 1.00 34.69 N ATOM 10941 C LYS C 413 −56.738 43.632 −91.510 1.00 30.14 C ATOM 10942 O LYS C 413 −56.966 42.566 −90.939 1.00 30.32 O ATOM 10943 N PHE C 414 −55.725 44.422 −91.185 1.00 29.43 N ATOM 10944 CA PHE C 414 −54.949 44.248 −89.966 1.00 29.84 C ATOM 10945 CB PHE C 414 −53.873 43.162 −90.126 1.00 30.59 C ATOM 10946 CG PHE C 414 −52.790 43.514 −91.108 1.00 31.07 C ATOM 10947 CD1 PHE C 414 −52.936 43.223 −92.458 1.00 30.91 C ATOM 10948 CE1 PHE C 414 −51.945 43.553 −93.366 1.00 31.64 C ATOM 10949 CZ PHE C 414 −50.785 44.173 −92.930 1.00 31.60 C ATOM 10950 CE2 PHE C 414 −50.625 44.466 −91.588 1.00 31.81 C ATOM 10951 CD2 PHE C 414 −51.623 44.139 −90.682 1.00 31.37 C ATOM 10952 C PHE C 414 −54.305 45.589 −89.668 1.00 29.80 C ATOM 10953 O PHE C 414 −54.223 46.454 −90.555 1.00 29.64 O ATOM 10954 N TRP C 415 −53.850 45.765 −88.432 1.00 28.78 N ATOM 10955 CA TRP C 415 −53.170 46.998 −88.064 1.00 28.14 C ATOM 10956 CB TRP C 415 −53.774 47.619 −86.801 1.00 29.01 C ATOM 10957 CG TRP C 415 −55.005 48.485 −87.056 1.00 29.70 C ATOM 10958 CD1 TRP C 415 −55.046 49.858 −87.354 1.00 29.56 C ATOM 10959 NE1 TRP C 415 −56.342 50.290 −87.513 1.00 29.12 N ATOM 10960 CE2 TRP C 415 −57.204 49.267 −87.339 1.00 29.99 C ATOM 10961 CD2 TRP C 415 −56.404 48.063 −87.041 1.00 29.10 C ATOM 10962 CE3 TRP C 415 −57.051 46.860 −86.821 1.00 29.53 C ATOM 10963 CZ3 TRP C 415 −58.452 46.831 −86.884 1.00 31.48 C ATOM 10964 CH2 TRP C 415 −59.205 47.990 −87.170 1.00 32.68 C ATOM 10965 CZ2 TRP C 415 −58.590 49.232 −87.405 1.00 31.47 C ATOM 10966 C TRP C 415 −51.692 46.805 −87.938 1.00 26.85 C ATOM 10967 O TRP C 415 −51.225 45.785 −87.426 1.00 26.36 O ATOM 10968 N GLY C 416 −50.947 47.781 −88.450 1.00 26.11 N ATOM 10969 CA GLY C 416 −49.492 47.806 −88.341 1.00 24.91 C ATOM 10970 C GLY C 416 −49.093 48.970 −87.463 1.00 23.86 C ATOM 10971 O GLY C 416 −49.324 50.131 −87.805 1.00 23.87 O ATOM 10972 N LEU C 417 −48.512 48.659 −86.316 1.00 22.91 N ATOM 10973 CA LEU C 417 −48.267 49.665 −85.311 1.00 22.85 C ATOM 10974 CB LEU C 417 −48.923 49.256 −84.002 1.00 22.05 C ATOM 10975 CG LEU C 417 −50.410 48.905 −84.089 1.00 21.54 C ATOM 10976 CD1 LEU C 417 −50.899 48.334 −82.771 1.00 20.93 C ATOM 10977 CD2 LEU C 417 −51.243 50.108 −84.514 1.00 21.03 C ATOM 10978 C LEU C 417 −46.784 49.869 −85.119 1.00 23.87 C ATOM 10979 O LEU C 417 −46.047 48.926 −84.847 1.00 24.49 O ATOM 10980 N THR C 418 −46.338 51.106 −85.279 1.00 25.14 N ATOM 10981 CA THR C 418 −44.925 51.401 −85.123 1.00 25.89 C ATOM 10982 CB THR C 418 −44.490 52.700 −85.859 1.00 27.18 C ATOM 10983 OG1 THR C 418 −43.135 53.018 −85.507 1.00 28.92 O ATOM 10984 CG2 THR C 418 −45.402 53.880 −85.515 1.00 27.26 C ATOM 10985 C THR C 418 −44.512 51.374 −83.649 1.00 24.74 C ATOM 10986 O THR C 418 −45.136 51.997 −82.799 1.00 23.05 O ATOM 10987 N ARG C 419 −43.453 50.616 −83.389 1.00 25.11 N ATOM 10988 CA ARG C 419 −42.970 50.286 −82.054 1.00 25.49 C ATOM 10989 CB ARG C 419 −41.810 49.307 −82.196 1.00 25.54 C ATOM 10990 CG ARG C 419 −41.188 48.824 −80.815 1.00 26.51 C ATOM 10991 CD ARG C 419 −39.758 48.375 −81.165 1.00 28.45 C ATOM 10992 NE ARG C 419 −38.791 49.480 −81.162 1.00 29.09 N ATOM 10993 CZ ARG C 419 −38.300 50.050 −80.058 1.00 30.69 C ATOM 10994 NH1 ARG C 419 −37.422 51.044 −80.154 1.00 31.68 N ATOM 10995 NH2 ARG C 419 −38.694 49.642 −78.852 1.00 30.69 N ATOM 10996 C ARG C 419 −42.559 51.504 −81.207 1.00 26.18 C ATOM 10997 O ARG C 419 −42.719 51.503 −79.986 1.00 27.26 O ATOM 10998 N SER C 420 −42.049 52.546 −81.847 1.00 26.70 N ATOM 10999 CA SER C 420 −41.657 53.750 −81.121 1.00 27.14 C ATOM 11000 CB SER C 420 −40.787 54.630 −81.996 1.00 28.41 C ATOM 11001 OG SER C 420 −41.527 55.041 −83.130 1.00 32.16 O ATOM 11002 C SER C 420 −42.866 54.547 −80.646 1.00 27.05 C ATOM 11003 O SER C 420 −42.735 55.458 −79.830 1.00 27.62 O ATOM 11004 N ALA C 421 −44.040 54.204 −81.162 1.00 27.34 N ATOM 11005 CA ALA C 421 −45.274 54.878 −80.777 1.00 27.16 C ATOM 11006 CB ALA C 421 −46.208 54.991 −81.968 1.00 26.54 C ATOM 11007 C ALA C 421 −45.989 54.195 −79.610 1.00 28.17 C ATOM 11008 O ALA C 421 −46.995 54.723 −79.117 1.00 29.31 O ATOM 11009 N LEU C 422 −45.476 53.043 −79.160 1.00 27.26 N ATOM 11010 CA LEU C 422 −46.175 52.233 −78.147 1.00 27.01 C ATOM 11011 CB LEU C 422 −46.448 50.821 −78.673 1.00 26.12 C ATOM 11012 CG LEU C 422 −47.114 50.591 −80.033 1.00 25.82 C ATOM 11013 CD1 LEU C 422 −46.909 49.145 −80.478 1.00 25.98 C ATOM 11014 CD2 LEU C 422 −48.593 50.943 −80.012 1.00 25.16 C ATOM 11015 C LEU C 422 −45.470 52.147 −76.779 1.00 28.04 C ATOM 11016 O LEU C 422 −44.248 52.316 −76.676 1.00 29.23 O ATOM 11017 N LEU C 423 −46.261 51.883 −75.737 1.00 27.88 N ATOM 11018 CA LEU C 423 −45.753 51.624 −74.389 1.00 28.03 C ATOM 11019 CB LEU C 423 −46.060 52.795 −73.450 1.00 26.84 C ATOM 11020 CG LEU C 423 −45.070 53.239 −72.365 1.00 26.34 C ATOM 11021 CD1 LEU C 423 −45.815 53.961 −71.259 1.00 26.27 C ATOM 11022 CD2 LEU C 423 −44.250 52.106 −71.774 1.00 26.60 C ATOM 11023 C LEU C 423 −46.436 50.362 −73.859 1.00 29.34 C ATOM 11024 O LEU C 423 −47.650 50.360 −73.639 1.00 29.98 O ATOM 11025 N PRO C 424 −45.668 49.276 −73.675 1.00 30.36 N ATOM 11026 CA PRO C 424 −46.239 48.064 −73.102 1.00 31.37 C ATOM 11027 CB PRO C 424 −45.080 47.066 −73.177 1.00 31.26 C ATOM 11028 CG PRO C 424 −43.852 47.919 −73.212 1.00 31.24 C ATOM 11029 CD PRO C 424 −44.257 49.088 −74.051 1.00 30.70 C ATOM 11030 C PRO C 424 −46.663 48.290 −71.655 1.00 32.48 C ATOM 11031 O PRO C 424 −45.967 48.970 −70.904 1.00 32.43 O ATOM 11032 N THR C 425 −47.813 47.747 −71.280 1.00 34.69 N ATOM 11033 CA THR C 425 −48.317 47.930 −69.935 1.00 37.50 C ATOM 11034 CB THR C 425 −49.548 48.881 −69.886 1.00 38.16 C ATOM 11035 OG1 THR C 425 −49.276 50.071 −70.632 1.00 37.03 O ATOM 11036 CG2 THR C 425 −49.892 49.279 −68.435 1.00 38.92 C ATOM 11037 C THR C 425 −48.649 46.592 −69.296 1.00 39.57 C ATOM 11038 O THR C 425 −49.005 45.625 −69.983 1.00 37.46 O ATOM 11039 N ILE C 426 −48.473 46.553 −67.975 1.00 43.46 N ATOM 11040 CA ILE C 426 −48.937 45.468 −67.121 1.00 45.95 C ATOM 11041 CB ILE C 426 −47.798 44.921 −66.194 1.00 46.03 C ATOM 11042 CG1 ILE C 426 −48.335 44.390 −64.852 1.00 45.69 C ATOM 11043 CD1 ILE C 426 −48.686 42.916 −64.857 1.00 46.22 C ATOM 11044 CG2 ILE C 426 −46.689 45.950 −66.000 1.00 45.70 C ATOM 11045 C ILE C 426 −50.162 45.989 −66.359 1.00 48.33 C ATOM 11046 O ILE C 426 −50.023 46.625 −65.303 1.00 49.38 O ATOM 11047 N PRO C 427 −51.369 45.731 −66.915 1.00 50.24 N ATOM 11048 CA PRO C 427 −52.650 46.315 −66.482 1.00 50.66 C ATOM 11049 CB PRO C 427 −53.656 45.712 −67.466 1.00 50.44 C ATOM 11050 CG PRO C 427 −53.038 44.418 −67.883 1.00 49.52 C ATOM 11051 CD PRO C 427 −51.568 44.706 −67.960 1.00 49.41 C ATOM 11052 C PRO C 427 −53.038 45.942 −65.052 1.00 51.88 C ATOM 11053 O PRO C 427 −52.543 44.944 −64.523 1.00 50.60 O ATOM 11054 N ASP C 428 −53.933 46.743 −64.463 1.00 54.14 N ATOM 11055 CA ASP C 428 −54.423 46.607 −63.075 1.00 54.72 C ATOM 11056 CB ASP C 428 −54.090 45.241 −62.450 1.00 57.03 C ATOM 11057 CG ASP C 428 −54.903 44.095 −63.050 1.00 57.54 C ATOM 11058 OD1 ASP C 428 −55.606 44.309 −64.064 1.00 57.45 O ATOM 11059 OD2 ASP C 428 −54.821 42.971 −62.507 1.00 58.01 O ATOM 11060 C ASP C 428 −53.878 47.722 −62.198 1.00 54.29 C ATOM 11061 O ASP C 428 −54.622 48.608 −61.782 1.00 55.54 O ATOM 11062 ZN ZN C 1 −52.468 59.031 −77.507 1.00 81.35 ZN ATOM 11063 O1 MOL B 1 −44.038 55.904 −93.534 1.00 40.49 O ATOM 11064 C2 MOL B 1 −44.496 56.170 −94.644 1.00 39.14 C ATOM 11065 C6 MOL B 1 −44.445 57.434 −95.230 1.00 39.50 C ATOM 11066 C9 MOL B 1 −43.947 58.660 −94.800 1.00 39.12 C ATOM 11067 C12 MOL B 1 −44.036 59.772 −95.633 1.00 37.74 C ATOM 11068 C13 MOL B 1 −44.621 59.663 −96.893 1.00 37.56 C ATOM 11069 C10 MOL B 1 −45.118 58.439 −97.325 1.00 37.83 C ATOM 11070 N3 MOL B 1 −45.677 58.322 −98.524 1.00 39.22 N ATOM 11071 C7 MOL B 1 −45.025 57.339 −96.487 1.00 38.40 C ATOM 11072 C3 MOL B 1 −45.482 55.904 −96.711 1.00 37.69 C ATOM 11073 N1 MOL B 1 −45.054 55.274 −95.456 1.00 38.23 N ATOM 11074 C1 MOL B 1 −45.250 53.859 −95.112 1.00 37.99 C ATOM 11075 C5 MOL B 1 −46.746 53.568 −94.971 1.00 37.76 C ATOM 11076 C8 MOL B 1 −46.973 52.088 −94.675 1.00 38.45 C ATOM 11077 C11 MOL B 1 −46.309 51.222 −95.747 1.00 39.26 C ATOM 11078 O3 MOL B 1 −46.773 50.114 −95.999 1.00 40.19 O ATOM 11079 N2 MOL B 1 −45.181 51.685 −96.448 1.00 38.85 N ATOM 11080 C4 MOL B 1 −44.631 52.952 −96.184 1.00 37.61 C ATOM 11081 O2 MOL B 1 −43.634 53.323 −96.799 1.00 36.34 O ATOM 11082 O HOH D 1 2.391 18.476 −57.850 1.00 17.05 O ATOM 11083 O HOH D 2 −12.951 15.067 −62.591 1.00 15.90 O ATOM 11084 O HOH D 3 −7.873 −10.205 −73.836 1.00 19.74 O ATOM 11085 O HOH D 4 −15.937 14.727 −33.157 1.00 16.16 O ATOM 11086 O HOH D 5 1.714 7.665 −7.104 1.00 39.27 O ATOM 11087 O HOH D 6 −25.723 27.363 −36.461 1.00 14.97 O ATOM 11088 O HOH D 7 −32.441 2.389 −42.642 1.00 22.10 O ATOM 11089 O HOH D 8 −32.137 7.614 −37.522 1.00 20.66 O ATOM 11090 O HOH D 9 −48.718 17.406 −35.548 1.00 38.21 O ATOM 11091 O HOH D 10 −48.302 27.267 −49.470 1.00 24.08 O ATOM 11092 O HOH D 11 −37.013 28.815 −26.871 1.00 20.05 O ATOM 11093 O HOH D 12 −60.235 51.997 −84.012 1.00 17.67 O ATOM 11094 O HOH D 13 −58.438 45.605 −79.491 1.00 30.89 O ATOM 11095 O HOH D 14 −22.402 45.556 −63.957 1.00 28.50 O ATOM 11096 O HOH D 15 −43.075 24.840 −58.945 1.00 18.58 O ATOM 11097 O HOH D 16 −48.921 52.096 −105.880 1.00 22.47 O ATOM 11098 O HOH D 17 −55.483 51.292 −103.346 1.00 40.75 O ATOM 11099 O HOH D 18 −58.085 49.218 −99.665 1.00 41.57 O END

TABLE 4 Atomic coordinates for CRBN(TBD):Pomalidomide (Murine protein) HEADER ---- XX-XXX-XX   xxxx  COMPND --- REMARK 3 REMARK 3 REFINEMENT. REMARK 3  PROGRAM   :  REFMAC 5.6.0117 REMARK 3  AUTHORS    : REMARK 3 REMARK 3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3  DATA USED IN REFINEMENT. REMARK 3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00 REMARK 3   RESOLUTION RANGE LOW (ANGSTROMS) : 30.00 REMARK 3   DATA CUTOFF        (SIGMA(F)) : NONE REMARK 3   COMPLETENESS FOR RANGE     (%) : 91.37 REMARK 3   NUMBER OF REFLECTIONS : 28750 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3  CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3  FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3  R VALUE   (WORKING + TEST SET) : 0.19883 REMARK 3  R VALUE      (WORKING SET) : 0.19655 REMARK 3  FREE R VALUE : 0.24000 REMARK 3  FREE R VALUE TEST SET SIZE   (%) : 5.1 REMARK 3  FREE R VALUE TEST SET COUNT : 1536 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3  TOTAL NUMBER OF BINS USED : 20 REMARK 3  BIN RESOLUTION RANGE HIGH : 2.000 REMARK 3  BIN RESOLUTION RANGE LOW : 2.052 REMARK 3  REFLECTION IN BIN     (WORKING SET) : 2036 REMARK 3  BIN COMPLETENESS (WORKING + TEST) (%) : 91.32 REMARK 3  BIN R VALUE        (WORKING SET) : 0.198 REMARK 3  BIN FREE R VALUE SET COUNT : 111 REMARK 3  BIN FREE R VALUE : 0.244 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3  ALL ATOMS          :     3157 REMARK 3 REMARK 3 B VALUES. REMARK 3  FROM WILSON PLOT       (A**2) : NULL REMARK 3  MEAN B VALUE     (OVERALL, A**2) : 22.876 REMARK 3  OVERALL ANISOTROPIC B VALUE. REMARK 3   B11 (A**2) : NULL REMARK 3   B22 (A**2) : NULL REMARK 3   B33 (A**2) : NULL REMARK 3   B12 (A**2) : NULL REMARK 3   B13 (A**2) : NULL REMARK 3   B23 (A**2) : NULL REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3  ESU BASED ON R VALUE                  (A):  0.182 REMARK 3  ESU BASED ON FREE R VALUE                (A):  0.167 REMARK 3  ESU BASED ON MAXIMUM LIKELIHOOD          (A):  0.105 REMARK 3  ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2):  6.738 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3  CORRELATION COEFFICIENT FO-FC   :  0.947 REMARK 3  CORRELATION COEFFICIENT FO-FC FREE :  0.930 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES     COUNT  RMS  WEIGHT REMARK 3  BOND LENGTHS REFINED ATOMS      (A):  3057 ;  0.017 ;  0.019 REMARK 3  BOND ANGLES REFINED ATOMS   (DEGREES):  4163 ;  1.723 ;  1.931 REMARK 3  TORSION ANGLES, PERIOD 1     (DEGREES):   356 ; 17.202 ;  5.000 REMARK 3  TORSION ANGLES, PERIOD 2     (DEGREES):   105 ; 41.339 ; 23.905 REMARK 3  TORSION ANGLES, PERIOD 3     (DEGREES):   516 ; 15.489 ; 15.000 REMARK 3  TORSION ANGLES, PERIOD 4     (DEGREES):    8 ; 12.460 ; 15.000 REMARK 3  CHIRAL-CENTER RESTRAINTS      (A**3):   465 ;  0.112 ;  0.200 REMARK 3  GENERAL PLANES REFINED ATOMS     (A):  2184 ;  0.019 ;  0.021 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT  RMS  WEIGHT REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3  NCS TYPE: LOCAL REMARK 3  NUMBER OF DIFFERENT NCS PAIRS : 6 REMARK 3 GROUP CHAIN1 RANGE CHAIN2 RANGE COUNT RMS WEIGHT REMARK 3 1 D 321 426 A 321 426 129 0.06 0.05 REMARK 3 2 D 321 425 B 321 425 123 0.07 0.05 REMARK 3 3 D 321 425 C 321 425 120 0.07 0.05 REMARK 3 4 A 321 425 B 321 425 127 0.06 0.05 REMARK 3 5 A 321 425 C 321 425 125 0.07 0.05 REMARK 3 6 B 321 427 C 321 427 127 0.07 0.05 REMARK 3 REMARK 3 TWIN DETAILS REMARK 3  NUMBER OF TWIN DOMAINS : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3  NUMBER OF TLS GROUPS : 4 REMARK 3  ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3  TLS GROUP : 1 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS     C  SSSEQI   TO   C  SSSEQI REMARK 3   RESIDUE RANGE :  D   −10        D   9999 REMARK 3   ORIGIN FOR THE GROUP (A):  −54.6488  −43.2246  −9.1355 REMARK 3   T TENSOR REMARK 3 T11:   0.0449 T22:   0.0609 REMARK 3 T33:   0.0451 T12:   0.0214 REMARK 3 T13: −0.0017 T23: −0.0302 REMARK 3   L TENSOR REMARK 3 L11:   1.8641 L22:   1.0729 REMARK 3 L33:   1.3703 L12: −0.9776 REMARK 3 L13: −0.3315 L23:   0.4284 REMARK 3   S TENSOR REMARK 3 S11:   0.0326 S12: −0.0774 S13:   0.0790 REMARK 3 S21: −0.0715 S22:   0.1331 S23: −0.0656 REMARK 3 S31: −0.0229 S32:   0.0512 S33: −0.1657 REMARK 3 REMARK 3  TLS GROUP : 2 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS    C  SSSEQI   TO   C  SSSEQI REMARK 3   RESIDUE RANGE :   A   −10        A   9999 REMARK 3   ORIGIN FOR THE GROUP (A):  −43.1674  −61.8511  −17.2067 REMARK 3   T TENSOR REMARK 3 T11:   0.0961 T22:   0.0577 REMARK 3 T33:   0.0433 T12:   0.0667 REMARK 3 T13: −0.0355 T23: −0.0218 REMARK 3   L TENSOR REMARK 3 L11:   1.2102 L22:   1.0632 REMARK 3 L33:   1.6053 L12: −0.7697 REMARK 3 L13:   0.6016 L23:   0.1378 REMARK 3   S TENSOR REMARK 3 S11:   0.1405 S12:   0.0556 S13: −0.0495 REMARK 3 S21: −0.1257 S22: −0.0515 S23: −0.0591 REMARK 3 S31:   0.0855 S32:   0.1366 S33: −0.0890 REMARK 3 REMARK 3  TLS GROUP : 3 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS    C  SSSEQI   TO   C  SSSEQI REMARK 3   RESIDUE RANGE :   B   −10        B   9999 REMARK 3   ORIGIN FOR THE GROUP (A):  −62.7105  −54.8717  −27.4066 REMARK 3   T TENSOR REMARK 3 T11:   0.0935 T22:   0.0782 REMARK 3 T33:   0.1060 T12:   0.0354 REMARK 3 T13: −0.0780 T23: −0.0561 REMARK 3   L TENSOR REMARK 3 L11:   0.9704 L22:   1.3670 REMARK 3 L33:   1.8001 L12: −0.0106 REMARK 3 L13:   0.5310 L23:   0.1324 REMARK 3   S TENSOR REMARK 3 S11:   0.0495 S12:   0.2002 S13: −0.0722 REMARK 3 S21: −0.1607 S22: −0.0989 S23:   0.2555 REMARK 3 S31:   0.1626 S32:   0.1066 S33:   0.0493 REMARK 3 REMARK 3  TLS GROUP : 4 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS    C  SSSEQI   TO   C  SSSEQI REMARK 3   RESIDUE RANGE :   C   −10        C   9999 REMARK 3   ORIGIN FOR THE GROUP (A):  −81.9343  −54.7508  −42.6687 REMARK 3   T TENSOR REMARK 3 T11:   0.0489 T22:   0.1203 REMARK 3 T33:   0.1222 T12:   0.0048 REMARK 3 T13: −0.0491 T23:   0.0798 REMARK 3   L TENSOR REMARK 3 L11:   1.8956 L22:   2.6463 REMARK 3 L33:   2.0505 L12: −0.0976 REMARK 3 L13:   1.1206 L23:   0.0699 REMARK 3   S TENSOR REMARK 3 S11: −0.0783 S12: −0.1677 S13: −0.1032 REMARK 3 S21:   0.0919 S22:   0.0341 S23: −0.2101 REMARK 3 S31:   0.0414 S32:   0.1410 S33:   0.0442 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3  METHOD USED  :  MASK REMARK 3  PARAMETERS FOR MASK CALCULATION REMARK 3  VDW PROBE RADIUS  :  1.20 REMARK 3  ION PROBE RADIUS   :  0.80 REMARK 3  SHRINKAGE RADIUS  :  0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT REMARK 3 U VALUES   : RESIDUAL ONLY REMARK 3 LINKR SER D 343 GLU D 360 gap LINKR SER B 343 GLU B 360 gap LINKR SER A 343 GLU A 360 gap LINKR SER C 343 GLU C 360 gap CRYST1 143.340  143.340  143.340  90.00  90.00  90.00 I 2 3 SCALE1   0.006976  0.000000  0.000000  0.00000 SCALE2   0.000000  0.006976  0.000000  0.00000 SCALE3   0.000000  0.000000  0.006976  0.00000 ATOM 1 N THR D 321 −67.228 −55.990 −7.326 1.00 34.39 N ATOM 2 CA THR D 321 −65.794 −55.577 −7.541 1.00 28.56 C ATOM 3 CB THR D 321 −65.154 −56.313 −8.776 1.00 21.71 C ATOM 4 OG1 THR D 321 −65.621 −55.728 −10.020 1.00 23.33 O ATOM 5 CG2 THR D 321 −65.359 −57.851 −8.761 1.00 29.98 C ATOM 6 C THR D 321 −65.626 −54.020 −7.761 1.00 19.04 C ATOM 7 O THR D 321 −64.506 −53.508 −7.689 1.00 17.84 O ATOM 8 N SER D 322 −66.714 −53.296 −8.068 1.00 15.19 N ATOM 9 CA SER D 322 −66.606 −51.868 −8.513 1.00 15.95 C ATOM 10 CB SER D 322 −67.923 −51.336 −9.092 1.00 16.65 C ATOM 11 OG SER D 322 −68.149 −51.941 −10.292 1.00 22.67 O ATOM 12 C SER D 322 −66.300 −50.931 −7.407 1.00 18.04 C ATOM 13 O SER D 322 −66.973 −50.972 −6.414 1.00 16.58 O ATOM 14 N LEU D 323 −65.392 −49.998 −7.644 1.00 11.36 N ATOM 15 CA LEU D 323 −65.082 −48.939 −6.703 1.00 14.58 C ATOM 16 CB LEU D 323 −63.570 −48.975 −6.316 1.00 10.60 C ATOM 17 CG LEU D 323 −63.134 −50.273 −5.588 1.00 14.95 C ATOM 18 CD1 LEU D 323 −61.628 −50.484 −5.478 1.00 13.48 C ATOM 19 CD2 LEU D 323 −63.699 −50.250 −4.194 1.00 16.93 C ATOM 20 C LEU D 323 −65.440 −47.634 −7.403 1.00 13.90 C ATOM 21 O LEU D 323 −64.820 −47.277 −8.398 1.00 11.28 O ATOM 22 N CYS D 324 −66.489 −46.978 −6.920 1.00 11.58 N ATOM 23 CA CYS D 324 −67.056 −45.788 −7.573 1.00 11.54 C ATOM 24 CB CYS D 324 −68.576 −45.946 −7.584 1.00 13.24 C ATOM 25 SG CYS D 324 −69.106 −47.222 −8.759 1.00 16.00 S ATOM 26 C CYS D 324 −66.713 −44.525 −6.808 1.00 12.36 C ATOM 27 O CYS D 324 −66.486 −44.582 −5.571 1.00 11.42 O ATOM 28 N CYS D 325 −66.776 −43.382 −7.504 1.00 10.46 N ATOM 29 CA CYS D 325 −66.578 −42.076 −6.895 1.00 11.76 C ATOM 30 CB CYS D 325 −66.806 −40.983 −7.959 1.00 11.15 C ATOM 31 SG CYS D 325 −66.789 −39.334 −7.236 1.00 13.37 S ATOM 32 C CYS D 325 −67.662 −41.936 −5.815 1.00 13.27 C ATOM 33 O CYS D 325 −68.865 −42.139 −6.090 1.00 12.84 O ATOM 34 N LYS D 326 −67.261 −41.646 −4.598 1.00 13.45 N ATOM 35 CA LYS D 326 −68.205 −41.572 −3.458 1.00 11.68 C ATOM 36 CB LYS D 326 −67.419 −41.408 −2.128 1.00 14.37 C ATOM 37 CG LYS D 326 −68.258 −41.217 −0.849 1.00 17.62 C ATOM 38 CD LYS D 326 −67.415 −41.302 0.456 1.00 16.62 C ATOM 39 CE LYS D 326 −66.623 −40.004 0.786 1.00 32.11 C ATOM 40 NZ LYS D 326 −65.750 −40.018 2.070 1.00 22.31 N ATOM 41 C LYS D 326 −69.206 −40.414 −3.614 1.00 12.19 C ATOM 42 O LYS D 326 −70.404 −40.520 −3.237 1.00 12.26 O ATOM 43 N GLN D 327 −68.721 −39.339 −4.184 1.00 11.39 N ATOM 44 CA GLN D 327 −69.498 −38.143 −4.369 1.00 13.99 C ATOM 45 CB GLN D 327 −68.590 −36.948 −4.774 1.00 14.69 C ATOM 46 CG GLN D 327 −69.369 −35.644 −5.044 1.00 14.75 C ATOM 47 CD GLN D 327 −70.212 −35.266 −3.836 1.00 19.02 C ATOM 48 OE1 GLN D 327 −69.704 −35.243 −2.720 1.00 19.40 O ATOM 49 NE2 GLN D 327 −71.541 −35.040 −4.042 1.00 14.58 N ATOM 50 C GLN D 327 −70.634 −38.336 −5.373 1.00 12.45 C ATOM 51 O GLN D 327 −71.796 −38.133 −5.006 1.00 14.23 O ATOM 52 N CYS D 328 −70.333 −38.586 −6.663 1.00 12.20 N ATOM 53 CA CYS D 328 −71.446 −38.674 −7.710 1.00 13.02 C ATOM 54 CB CYS D 328 −70.942 −38.252 −9.110 1.00 10.26 C ATOM 55 SG CYS D 328 −69.589 −39.316 −9.751 1.00 11.74 S ATOM 56 C CYS D 328 −72.062 −40.085 −7.766 1.00 12.49 C ATOM 57 O CYS D 328 −73.070 −40.327 −8.444 1.00 11.53 O ATOM 58 N GLN D 329 −71.387 −41.021 −7.102 1.00 12.62 N ATOM 59 CA GLN D 329 −71.913 −42.368 −6.786 1.00 16.74 C ATOM 60 CB GLN D 329 −73.328 −42.277 −6.137 1.00 16.32 C ATOM 61 CG GLN D 329 −73.315 −41.478 −4.828 1.00 15.01 C ATOM 62 CD GLN D 329 −74.694 −41.340 −4.201 1.00 20.72 C ATOM 63 OE1 GLN D 329 −75.464 −42.290 −4.192 1.00 20.99 O ATOM 64 NE2 GLN D 329 −75.042 −40.124 −3.747 1.00 24.15 N ATOM 65 C GLN D 329 −71.930 −43.314 −7.955 1.00 18.94 C ATOM 66 O GLN D 329 −71.707 −44.512 −7.781 1.00 21.46 O ATOM 67 N GLU D 330 −72.168 −42.799 −9.158 1.00 14.80 N ATOM 68 CA AGLU D 330 −72.496 −43.677 −10.261 0.50 18.10 C ATOM 69 CA BGLU D 330 −72.501 −43.634 −10.310 0.50 16.38 C ATOM 70 CB AGLU D 330 −73.682 −43.112 −11.079 0.50 22.68 C ATOM 71 CB BGLU D 330 −73.547 −42.926 −11.195 0.50 17.07 C ATOM 72 CG AGLU D 330 −74.877 −42.576 −10.267 0.50 23.78 C ATOM 73 CG BGLU D 330 −72.942 −41.929 −12.180 0.50 13.97 C ATOM 74 CD AGLU D 330 −75.530 −43.636 −9.387 0.50 29.20 C ATOM 75 CD BGLU D 330 −73.963 −41.151 −12.985 0.50 17.67 C ATOM 76 OE1 AGLU D 330 −75.262 −44.831 −9.615 0.50 31.28 O ATOM 77 OE1 BGLU D 330 −75.138 −41.551 −13.041 0.50 14.73 O ATOM 78 OE2 AGLU D 330 −76.322 −43.279 −8.470 0.50 27.78 O ATOM 79 OE2 BGLU D 330 −73.586 −40.117 −13.549 0.50 17.61 O ATOM 80 C GLU D 330 −71.267 −43.935 −11.167 1.00 18.98 C ATOM 81 O GLU D 330 −71.291 −44.816 −12.043 1.00 15.50 O ATOM 82 N THR D 331 −70.198 −43.174 −10.959 1.00 15.79 N ATOM 83 CA THR D 331 −69.018 −43.257 −11.827 1.00 13.14 C ATOM 84 CB THR D 331 −68.355 −41.860 −11.996 1.00 14.10 C ATOM 85 OG1 THR D 331 −69.328 −40.916 −12.486 1.00 16.15 O ATOM 86 CG2 THR D 331 −67.130 −41.876 −12.976 1.00 9.86 C ATOM 87 C THR D 331 −67.997 −44.258 −11.259 1.00 13.51 C ATOM 88 O THR D 331 −67.382 −44.038 −10.178 1.00 11.35 O ATOM 89 N GLU D 332 −67.731 −45.313 −12.024 1.00 11.11 N ATOM 90 CA GLU D 332 −66.712 −46.269 −11.592 1.00 12.74 C ATOM 91 CB GLU D 332 −66.878 −47.605 −12.313 1.00 11.85 C ATOM 92 CG GLU D 332 −65.921 −48.686 −11.777 1.00 15.26 C ATOM 93 CD GLU D 332 −66.108 −49.983 −12.549 1.00 15.98 C ATOM 94 OE1 GLU D 332 −67.063 −50.728 −12.267 1.00 15.76 O ATOM 95 OE2 GLU D 332 −65.378 −50.175 −13.504 1.00 14.09 O ATOM 96 C GLU D 332 −65.332 −45.716 −11.882 1.00 13.41 C ATOM 97 O GLU D 332 −65.076 −45.269 −12.990 1.00 9.76 O ATOM 98 N ILE D 333 −64.440 −45.805 −10.886 1.00 11.09 N ATOM 99 CA ILE D 333 −63.029 −45.359 −11.037 1.00 10.48 C ATOM 100 CB ILE D 333 −62.618 −44.490 −9.809 1.00 11.79 C ATOM 101 CG1 ILE D 333 −63.653 −43.356 −9.631 1.00 11.10 C ATOM 102 CD1 ILE D 333 −63.750 −42.417 −10.859 1.00 9.78 C ATOM 103 CG2 ILE D 333 −61.213 −43.908 −9.974 1.00 10.75 C ATOM 104 C ILE D 333 −62.095 −46.546 −11.189 1.00 9.32 C ATOM 105 O ILE D 333 −61.179 −46.513 −11.985 1.00 11.67 O ATOM 106 N THR D 334 −62.332 −47.619 −10.451 1.00 11.43 N ATOM 107 CA THR D 334 −61.461 −48.809 −10.650 1.00 13.43 C ATOM 108 CB THR D 334 −60.072 −48.626 −9.953 1.00 13.67 C ATOM 109 OG1 THR D 334 −59.168 −49.627 −10.417 1.00 12.55 O ATOM 110 CG2 THR D 334 −60.178 −48.708 −8.394 1.00 13.54 C ATOM 111 C THR D 334 −62.224 −50.014 −10.172 1.00 12.78 C ATOM 112 O THR D 334 −63.422 −49.891 −9.879 1.00 10.19 O ATOM 113 N THR D 335 −61.572 −51.185 −10.140 1.00 11.03 N ATOM 114 CA THR D 335 −62.191 −52.389 −9.579 1.00 10.78 C ATOM 115 CB THR D 335 −62.618 −53.405 −10.675 1.00 11.10 C ATOM 116 OG1 THR D 335 −61.469 −54.087 −11.182 1.00 11.10 O ATOM 117 CG2 THR D 335 −63.369 −52.710 −11.849 1.00 11.42 C ATOM 118 C THR D 335 −61.168 −53.075 −8.684 1.00 11.76 C ATOM 119 O THR D 335 −59.942 −52.872 −8.849 1.00 11.57 O ATOM 120 N LYS D 336 −61.632 −53.892 −7.753 1.00 11.47 N ATOM 121 CA LYS D 336 −60.722 −54.607 −6.865 1.00 13.75 C ATOM 122 CB LYS D 336 −61.521 −55.503 −5.909 1.00 20.64 C ATOM 123 CG LYS D 336 −62.227 −54.735 −4.812 1.00 30.62 C ATOM 124 CD LYS D 336 −62.903 −55.698 −3.826 1.00 33.50 C ATOM 125 CE LYS D 336 −63.747 −54.950 −2.795 1.00 35.38 C ATOM 126 NZ LYS D 336 −64.601 −55.948 −2.077 1.00 39.43 N ATOM 127 C LYS D 336 −59.764 −55.475 −7.622 1.00 13.56 C ATOM 128 O LYS D 336 −58.722 −55.830 −7.105 1.00 14.30 O ATOM 129 N ASN D 337 −60.130 −55.867 −8.848 1.00 11.55 N ATOM 130 CA ASN D 337 −59.265 −56.749 −9.637 1.00 12.27 C ATOM 131 CB ASN D 337 −59.978 −57.212 −10.931 1.00 12.51 C ATOM 132 CG ASN D 337 −61.178 −58.053 −10.643 1.00 19.58 C ATOM 133 OD1 ASN D 337 −62.313 −57.694 −10.963 1.00 21.91 O ATOM 134 ND2 ASN D 337 −60.948 −59.159 −9.999 1.00 19.26 N ATOM 135 C ASN D 337 −57.984 −56.054 −10.007 1.00 13.06 C ATOM 136 O ASN D 337 −57.025 −56.698 −10.335 1.00 12.99 O ATOM 137 N GLU D 338 −57.989 −54.716 −9.978 1.00 12.28 N ATOM 138 CA GLU D 338 −56.825 −53.923 −10.425 1.00 14.52 C ATOM 139 CB GLU D 338 −57.262 −52.638 −11.176 1.00 10.20 C ATOM 140 CG GLU D 338 −58.194 −52.913 −12.333 1.00 11.30 C ATOM 141 CD GLU D 338 −57.585 −53.853 −13.357 1.00 13.59 C ATOM 142 OE1 GLU D 338 −56.401 −53.686 −13.714 1.00 13.97 O ATOM 143 OE2 GLU D 338 −58.299 −54.774 −13.804 1.00 17.16 O ATOM 144 C GLU D 338 −55.854 −53.578 −9.316 1.00 13.62 C ATOM 145 O GLU D 338 −54.803 −52.977 −9.587 1.00 12.34 O ATOM 146 N ILE D 339 −56.146 −54.025 −8.086 1.00 11.79 N ATOM 147 CA ILE D 339 −55.329 −53.601 −6.912 1.00 14.46 C ATOM 148 CB ILE D 339 −56.104 −53.87 −5.570 1.00 14.63 C ATOM 149 CG1 ILE D 339 −57.371 −52.992 −5.435 1.00 13.29 C ATOM 150 CD1 ILE D 339 −58.263 −53.446 −4.282 1.00 17.57 C ATOM 151 CG2 ILE D 339 −55.196 −53.842 −4.344 1.00 11.80 C ATOM 152 C ILE D 339 −54.033 −54.428 −6.963 1.00 12.36 C ATOM 153 O ILE D 339 −54.077 −55.613 −7.307 1.00 9.97 O ATOM 154 N PHE D 340 −52.893 −53.811 −6.636 1.00 9.98 N ATOM 155 CA PHE D 340 −51.621 −54.530 −6.521 1.00 12.72 C ATOM 156 CB PHE D 340 −50.850 −54.600 −7.886 1.00 11.78 C ATOM 157 CG PHE D 340 −50.178 −53.300 −8.274 1.00 11.81 C ATOM 158 CD1 PHE D 340 −48.777 −53.133 −8.123 1.00 12.97 C ATOM 159 CE1 PHE D 340 −48.182 −51.900 −8.442 1.00 12.13 C ATOM 160 CZ PHE D 340 −48.989 −50.824 −8.873 1.00 11.11 C ATOM 161 CE2 PHE D 340 −50.342 −50.994 −9.071 1.00 11.64 C ATOM 162 CD2 PHE D 340 −50.949 −52.210 −8.762 1.00 10.10 C ATOM 163 C PHE D 340 −50.809 −53.795 −5.449 1.00 16.76 C ATOM 164 O PHE D 340 −51.210 −52.719 −5.012 1.00 16.33 O ATOM 165 N SER D 341 −49.671 −54.368 −5.058 1.00 18.59 N ATOM 166 CA SER D 341 −48.870 −53.838 −3.970 1.00 18.62 C ATOM 167 CB SER D 341 −48.740 −54.877 −2.868 1.00 26.20 C ATOM 168 OG SER D 341 −48.024 −54.372 −1.746 1.00 34.73 O ATOM 169 C SER D 341 −47.522 −53.421 −4.522 1.00 17.47 C ATOM 170 O SER D 341 −46.761 −54.248 −4.971 1.00 15.83 O ATOM 171 N LEU D 342 −47.247 −52.107 −4.524 1.00 18.98 N ATOM 172 CA LEU D 342 −45.927 −51.606 −4.985 1.00 24.10 C ATOM 173 CB LEU D 342 −46.033 −50.156 −5.478 1.00 24.70 C ATOM 174 CG LEU D 342 −45.454 −49.626 −6.779 1.00 30.75 C ATOM 175 CD1 LEU D 342 −44.729 −48.330 −6.525 1.00 27.48 C ATOM 176 CD2 LEU D 342 −44.501 −50.609 −7.434 1.00 34.18 C ATOM 177 C LEU D 342 −44.888 −51.734 −3.840 1.00 34.50 C ATOM 178 O LEU D 342 −43.752 −52.165 −4.082 1.00 30.45 O ATOM 179 N SER D 343 −45.291 −51.417 −2.596 1.00 30.56 N ATOM 180 CA SER D 343 −44.440 −51.658 −1.399 1.00 62.05 C ATOM 181 CB SER D 343 −45.222 −51.403 −0.088 1.00 55.95 C ATOM 182 OG SER D 343 −46.316 −52.295 0.049 1.00 59.16 O ATOM 183 C SER D 343 −43.802 −53.066 −1.381 1.00 74.57 C ATOM 184 O SER D 343 −43.159 −53.475 −0.406 1.00 80.57 O ATOM 185 N GLU D 360 −54.707 −46.012 3.496 1.00 32.78 N ATOM 186 CA GLU D 360 −55.229 −44.691 3.067 1.00 41.60 C ATOM 187 CB GLU D 360 −54.466 −43.536 3.771 1.00 47.05 C ATOM 188 CG GLU D 360 −54.686 −42.127 3.193 1.00 55.26 C ATOM 189 CD GLU D 360 −55.669 −41.257 3.987 1.00 65.56 C ATOM 190 OE1 GLU D 360 −56.577 −40.656 3.369 1.00 70.43 O ATOM 191 OE2 GLU D 360 −55.521 −41.145 5.219 1.00 43.69 O ATOM 192 C GLU D 360 −55.242 −44.524 1.517 1.00 35.47 C ATOM 193 O GLU D 360 −56.235 −44.012 0.944 1.00 24.22 O ATOM 194 N THR D 361 −54.156 −44.978 0.863 1.00 25.92 N ATOM 195 CA THR D 361 −53.985 −44.859 −0.620 1.00 27.67 C ATOM 196 CB THR D 361 −52.744 −44.010 −0.996 1.00 30.46 C ATOM 197 OG1 THR D 361 −52.879 −42.680 −0.453 1.00 35.07 O ATOM 198 CG2 THR D 361 −52.615 −43.922 −2.509 1.00 26.94 C ATOM 199 C THR D 361 −53.896 −46.231 −1.329 1.00 20.63 C ATOM 200 O THR D 361 −52.977 −46.991 −1.112 1.00 25.53 O ATOM 201 N LEU D 362 −54.871 −46.519 −2.171 1.00 18.65 N ATOM 202 CA LEU D 362 −54.986 −47.780 −2.849 1.00 16.05 C ATOM 203 CB LEU D 362 −56.474 −48.000 −3.165 1.00 17.05 C ATOM 204 CG LEU D 362 −56.921 −49.338 −3.730 1.00 18.27 C ATOM 205 CD1 LEU D 362 −56.930 −50.361 −2.592 1.00 19.21 C ATOM 206 CD2 LEU D 362 −58.318 −49.184 −4.304 1.00 23.17 C ATOM 207 C LEU D 362 −54.190 −47.676 −4.157 1.00 18.06 C ATOM 208 O LEU D 362 −54.278 −46.664 −4.835 1.00 16.54 O ATOM 209 N THR D 363 −53.373 −48.675 −4.491 1.00 12.90 N ATOM 210 CA THR D 363 −52.659 −48.615 −5.773 1.00 13.43 C ATOM 211 CB THR D 363 −51.131 −48.823 −5.599 1.00 16.84 C ATOM 212 OG1 THR D 363 −50.882 −50.071 −4.902 1.00 15.09 O ATOM 213 CG2 THR D 363 −50.510 −47.656 −4.790 1.00 18.98 C ATOM 214 C THR D 363 −53.272 −49.632 −6.749 1.00 13.28 C ATOM 215 O THR D 363 −53.441 −50.809 −6.396 1.00 11.09 O ATOM 216 N VAL D 364 −53.619 −49.177 −7.959 1.00 10.26 N ATOM 217 CA VAL D 364 −54.248 −50.061 −8.969 1.00 9.75 C ATOM 218 CB VAL D 364 −55.775 −49.758 −9.137 1.00 9.30 C ATOM 219 CG1 VAL D 364 −56.525 −50.033 −7.832 1.00 10.55 C ATOM 220 CG2 VAL D 364 −56.003 −48.314 −9.566 1.00 9.33 C ATOM 221 C VAL D 364 −53.564 −49.913 −10.312 1.00 9.78 C ATOM 222 O VAL D 364 −53.021 −48.813 −10.616 1.00 9.01 O ATOM 223 N TYR D 365 −53.534 −51.004 −11.124 1.00 8.58 N ATOM 224 CA TYR D 365 −52.859 −50.920 −12.419 1.00 9.67 C ATOM 225 CB TYR D 365 −52.721 −52.334 −13.056 1.00 9.61 C ATOM 226 CG TYR D 365 −51.674 −53.174 −12.436 1.00 12.91 C ATOM 227 CD1 TYR D 365 −50.299 −52.807 −12.530 1.00 11.67 C ATOM 228 CE1 TYR D 365 −49.291 −53.625 −12.013 1.00 10.11 C ATOM 229 CZ TYR D 365 −49.642 −54.753 −11.351 1.00 12.37 C ATOM 230 OH TYR D 365 −48.657 −55.515 −10.825 1.00 11.48 O ATOM 231 CE2 TYR D 365 −50.976 −55.178 −11.267 1.00 10.77 C ATOM 232 CD2 TYR D 365 −52.002 −54.371 −11.781 1.00 11.08 C ATOM 233 C TYR D 365 −53.651 −50.074 −13.421 1.00 9.56 C ATOM 234 O TYR D 365 −53.083 −49.500 −14.355 1.00 11.17 O ATOM 235 N LYS D 366 −54.977 −50.081 −13.265 1.00 9.37 N ATOM 236 CA LYS D 366 −55.884 −49.466 −14.253 1.00 11.01 C ATOM 237 CB LYS D 366 −56.496 −50.574 −15.118 1.00 9.42 C ATOM 238 CG LYS D 366 −55.502 −51.172 −16.109 1.00 11.57 C ATOM 239 CD LYS D 366 −55.507 −50.363 −17.402 1.00 11.80 C ATOM 240 CE LYS D 366 −54.295 −50.744 −18.254 1.00 17.68 C ATOM 241 NZ LYS D 366 −54.182 −49.886 −19.458 1.00 12.69 N ATOM 242 C LYS D 366 −57.020 −48.717 −13.540 1.00 10.84 C ATOM 243 O LYS D 366 −57.528 −49.177 −12.476 1.00 11.53 O ATOM 244 N ALA D 367 −57.452 −47.621 −14.148 1.00 9.83 N ATOM 245 CA ALA D 367 −58.578 −46.809 −13.632 1.00 12.18 C ATOM 246 CB ALA D 367 −58.052 −45.679 −12.724 1.00 12.33 C ATOM 247 C ALA D 367 −59.314 −46.202 −14.813 1.00 9.51 C ATOM 248 O ALA D 367 −58.770 −46.157 −15.954 1.00 11.57 O ATOM 249 N SER D 368 −60.519 −45.690 −14.554 1.00 9.41 N ATOM 250 CA SER D 368 −61.313 −45.117 −15.629 1.00 9.57 C ATOM 251 CB SER D 368 −62.385 −46.171 −16.031 1.00 8.79 C ATOM 252 OG SER D 368 −63.123 −46.538 −14.882 1.00 11.07 O ATOM 253 C SER D 368 −62.043 −43.867 −15.153 1.00 9.50 C ATOM 254 O SER D 368 −62.219 −43.659 −13.905 1.00 9.81 O ATOM 255 N ASN D 369 −62.495 −43.071 −16.097 1.00 8.82 N ATOM 256 CA ASN D 369 −63.364 −41.933 −15.809 1.00 11.14 C ATOM 257 CB ASN D 369 −64.677 −42.444 −15.170 1.00 10.35 C ATOM 258 CG ASN D 369 −65.455 −43.372 −16.114 1.00 16.33 C ATOM 259 OD1 ASN D 369 −65.974 −44.410 −15.713 1.00 14.22 O ATOM 260 ND2 ASN D 369 −65.483 −43.021 −17.355 1.00 12.04 N ATOM 261 C ASN D 369 −62.675 −40.879 −14.933 1.00 14.38 C ATOM 262 O ASN D 369 −63.326 −40.131 −14.212 1.00 12.97 O ATOM 263 N LEU D 370 −61.357 −40.799 −15.028 1.00 10.49 N ATOM 264 CA LEU D 370 −60.624 −39.752 −14.319 1.00 12.42 C ATOM 265 CB LEU D 370 −59.444 −40.380 −13.567 1.00 10.40 C ATOM 266 CG LEU D 370 −59.813 −41.251 −12.353 1.00 11.12 C ATOM 267 CD1 LEU D 370 −58.565 −41.969 −11.803 1.00 10.26 C ATOM 268 CD2 LEU D 370 −60.449 −40.356 −11.272 1.00 12.03 C ATOM 269 C LEU D 370 −60.083 −38.750 −15.350 1.00 12.72 C ATOM 270 O LEU D 370 −59.600 −39.166 −16.434 1.00 13.55 O ATOM 271 N ASN D 371 −60.161 −37.470 −15.037 1.00 13.32 N ATOM 272 CA ASN D 371 −59.398 −36.416 −15.780 1.00 16.00 C ATOM 273 CB ASN D 371 −60.249 −35.146 −15.900 1.00 17.19 C ATOM 274 CG ASN D 371 −61.394 −35.304 −16.897 1.00 19.75 C ATOM 275 OD1 ASN D 371 −61.273 −36.039 −17.886 1.00 22.73 O ATOM 276 ND2 ASN D 371 −62.507 −34.658 −16.621 1.00 17.09 N ATOM 277 C ASN D 371 −58.075 −36.076 −15.103 1.00 16.05 C ATOM 278 O ASN D 371 −58.012 −35.898 −13.887 1.00 17.20 O ATOM 279 N LEU D 372 −57.039 −35.877 −15.891 1.00 14.64 N ATOM 280 CA LEU D 372 −55.723 −35.510 −15.341 1.00 16.60 C ATOM 281 CB LEU D 372 −54.587 −36.181 −16.153 1.00 18.56 C ATOM 282 CG LEU D 372 −54.554 −37.722 −16.216 1.00 24.16 C ATOM 283 CD1 LEU D 372 −53.493 −38.171 −17.248 1.00 20.65 C ATOM 284 CD2 LEU D 372 −54.313 −38.418 −14.860 1.00 19.93 C ATOM 285 C LEU D 372 −55.578 −34.009 −15.370 1.00 21.79 C ATOM 286 O LEU D 372 −55.874 −33.377 −16.380 1.00 21.71 O ATOM 287 N ILE D 373 −55.136 −33.439 −14.255 1.00 20.03 N ATOM 288 CA ILE D 373 −54.923 −31.992 −14.150 1.00 23.81 C ATOM 289 CB ILE D 373 −55.562 −31.407 −12.875 1.00 20.77 C ATOM 290 CG1 ILE D 373 −57.059 −31.749 −12.811 1.00 22.49 C ATOM 291 CD1 ILE D 373 −57.861 −31.134 −13.949 1.00 25.68 C ATOM 292 CG2 ILE D 373 −55.304 −29.894 −12.792 1.00 21.65 C ATOM 293 C ILE D 373 −53.438 −31.669 −14.090 1.00 28.50 C ATOM 294 O ILE D 373 −52.736 −32.079 −13.130 1.00 23.54 O ATOM 295 N GLY D 374 −52.956 −30.930 −15.088 1.00 26.30 N ATOM 296 CA GLY D 374 −51.577 −30.417 −15.055 1.00 26.84 C ATOM 297 C GLY D 374 −50.579 −31.394 −15.627 1.00 27.07 C ATOM 298 O GLY D 374 −50.960 −32.312 −16.334 1.00 24.33 O ATOM 299 N ARG D 375 −49.302 −31.204 −15.289 1.00 23.42 N ATOM 300 CA ARG D 375 −48.184 −32.025 −15.801 1.00 26.07 C ATOM 301 CB ARG D 375 −47.092 −31.109 −16.393 1.00 28.25 C ATOM 302 CG ARG D 375 −47.624 −30.103 −17.423 1.00 35.44 C ATOM 303 CD ARG D 375 −46.785 −28.828 −17.518 1.00 42.70 C ATOM 304 NE ARG D 375 −45.343 −29.082 −17.567 1.00 47.46 N ATOM 305 CZ ARG D 375 −44.522 −28.970 −16.523 1.00 49.67 C ATOM 306 NH1 ARG D 375 −44.991 −28.606 −15.337 1.00 50.71 N ATOM 307 NH2 ARG D 375 −43.230 −29.222 −16.664 1.00 59.40 N ATOM 308 C ARG D 375 −47.579 −32.818 −14.647 1.00 20.41 C ATOM 309 O ARG D 375 −47.659 −32.383 −13.513 1.00 21.68 O ATOM 310 N PRO D 376 −46.929 −33.960 −14.940 1.00 21.94 N ATOM 311 CA PRO D 376 −46.292 −34.755 −13.895 1.00 20.77 C ATOM 312 CB PRO D 376 −45.560 −35.835 −14.682 1.00 25.05 C ATOM 313 CG PRO D 376 −46.333 −35.941 −15.962 1.00 29.14 C ATOM 314 CD PRO D 376 −46.654 −34.512 −16.273 1.00 22.40 C ATOM 315 C PRO D 376 −45.285 −33.973 −13.068 1.00 21.95 C ATOM 316 O PRO D 376 −44.611 −33.105 −13.596 1.00 20.20 O ATOM 317 N SER D 377 −45.187 −34.297 −11.779 1.00 18.40 N ATOM 318 CA SER D 377 −44.141 −33.726 −10.910 1.00 19.62 C ATOM 319 CB SER D 377 −44.740 −32.600 −10.009 1.00 18.99 C ATOM 320 OG SER D 377 −43.835 −32.242 −8.957 1.00 22.29 O ATOM 321 C SER D 377 −43.560 −34.836 −10.043 1.00 17.21 C ATOM 322 O SER D 377 −44.312 −35.720 −9.573 1.00 15.64 O ATOM 323 N THR D 378 −42.251 −34.783 −9.796 1.00 13.61 N ATOM 324 CA THR D 378 −41.634 −35.693 −8.810 1.00 16.90 C ATOM 325 CB THR D 378 −40.196 −36.078 −9.156 1.00 14.97 C ATOM 326 OG1 THR D 378 −39.428 −34.896 −9.299 1.00 14.71 O ATOM 327 CG2 THR D 378 −40.133 −36.877 −10.444 1.00 15.92 C ATOM 328 C THR D 378 −41.559 −35.078 −7.399 1.00 14.84 C ATOM 329 O THR D 378 −41.094 −35.741 −6.482 1.00 15.16 O ATOM 330 N VAL D 379 −41.964 −33.813 −7.268 1.00 13.54 N ATOM 331 CA VAL D 379 −41.884 −33.050 −6.006 1.00 15.88 C ATOM 332 CB VAL D 379 −42.508 −31.650 −6.234 1.00 18.76 C ATOM 333 CG1 VAL D 379 −42.925 −30.976 −4.947 1.00 23.06 C ATOM 334 CG2 VAL D 379 −41.537 −30.771 −7.023 1.00 22.47 C ATOM 335 C VAL D 379 −42.623 −33.828 −4.876 1.00 16.58 C ATOM 336 O VAL D 379 −43.767 −34.147 −5.028 1.00 16.14 O ATOM 337 N HIS D 380 −41.921 −34.202 −3.805 1.00 12.95 N ATOM 338 CA HIS D 380 −42.518 −34.987 −2.696 1.00 14.86 C ATOM 339 CB HIS D 380 −43.564 −34.154 −1.900 1.00 13.67 C ATOM 340 CG HIS D 380 −43.044 −32.832 −1.374 1.00 14.41 C ATOM 341 ND1 HIS D 380 −41.952 −32.739 −0.595 1.00 14.59 N ATOM 342 CE1 HIS D 380 −41.704 −31.445 −0.330 1.00 13.72 C ATOM 343 NE2 HIS D 380 −42.687 −30.713 −0.894 1.00 12.95 N ATOM 344 CD2 HIS D 380 −43.512 −31.527 −1.551 1.00 14.45 C ATOM 345 C HIS D 380 −43.172 −36.307 −3.105 1.00 15.09 C ATOM 346 O HIS D 380 −44.098 −36.787 −2.399 1.00 18.61 O ATOM 347 N SER D 381 −42.760 −36.910 −4.235 1.00 16.93 N ATOM 348 CA SER D 381 −43.444 −38.142 −4.706 1.00 16.00 C ATOM 349 CB SER D 381 −42.788 −38.721 −5.960 1.00 19.80 C ATOM 350 OG SER D 381 −43.404 −39.969 −6.285 1.00 17.26 O ATOM 351 C SER D 381 −43.479 −39.235 −3.630 1.00 19.44 C ATOM 352 O SER D 381 −42.419 −39.567 −3.027 1.00 14.52 O ATOM 353 N TRP D 382 −44.664 −39.805 −3.369 1.00 12.85 N ATOM 354 CA TRP D 382 −44.713 −40.957 −2.441 1.00 16.94 C ATOM 355 CB TRP D 382 −46.131 −41.281 −1.999 1.00 18.71 C ATOM 356 CG TRP D 382 −46.805 −40.122 −1.347 1.00 17.72 C ATOM 357 CD1 TRP D 382 −46.232 −39.158 −0.479 1.00 22.58 C ATOM 358 NE1 TRP D 382 −47.178 −38.219 −0.097 1.00 15.78 N ATOM 359 CE2 TRP D 382 −48.371 −38.494 −0.716 1.00 16.33 C ATOM 360 CD2 TRP D 382 −48.174 −39.705 −1.539 1.00 16.25 C ATOM 361 CE3 TRP D 382 −49.244 −40.201 −2.275 1.00 21.53 C ATOM 362 CZ3 TRP D 382 −50.463 −39.537 −2.217 1.00 15.17 C ATOM 363 CH2 TRP D 382 −50.642 −38.391 −1.421 1.00 19.34 C ATOM 364 CZ2 TRP D 382 −49.580 −37.839 −0.666 1.00 17.34 C ATOM 365 C TRP D 382 −44.058 −42.218 −2.935 1.00 19.12 C ATOM 366 O TRP D 382 −43.856 −43.147 −2.149 1.00 16.44 O ATOM 367 N PHE D 383 −43.786 −42.288 −4.245 1.00 18.15 N ATOM 368 CA PHE D 383 −43.213 −43.515 −4.879 1.00 16.37 C ATOM 369 CB PHE D 383 −44.294 −44.188 −5.782 1.00 14.45 C ATOM 370 CG PHE D 383 −45.514 −44.634 −5.014 1.00 20.08 C ATOM 371 CD1 PHE D 383 −45.492 −45.811 −4.260 1.00 21.79 C ATOM 372 CE1 PHE D 383 −46.621 −46.233 −3.562 1.00 26.15 C ATOM 373 CZ PHE D 383 −47.778 −45.448 −3.572 1.00 18.25 C ATOM 374 CE2 PHE D 383 −47.812 −44.276 −4.317 1.00 17.32 C ATOM 375 CD2 PHE D 383 −46.674 −43.860 −5.009 1.00 14.38 C ATOM 376 C PHE D 383 −41.933 −43.159 −5.656 1.00 18.80 C ATOM 377 O PHE D 383 −41.985 −42.850 −6.851 1.00 17.18 O ATOM 378 N PRO D 384 −40.765 −43.168 −4.972 1.00 19.77 N ATOM 379 CA PRO D 384 −39.516 −42.830 −5.731 1.00 20.37 C ATOM 380 CB PRO D 384 −38.369 −43.220 −4.759 1.00 21.23 C ATOM 381 CG PRO D 384 −39.007 −43.126 −3.401 1.00 24.39 C ATOM 382 CD PRO D 384 −40.471 −43.593 −3.588 1.00 16.66 C ATOM 383 C PRO D 384 −39.377 −43.489 −7.100 1.00 17.34 C ATOM 384 O PRO D 384 −39.722 −44.660 −7.290 1.00 20.17 O ATOM 385 N GLY D 385 −38.958 −42.701 −8.082 1.00 14.40 N ATOM 386 CA GLY D 385 −38.925 −43.184 −9.454 1.00 17.24 C ATOM 387 C GLY D 385 −40.200 −42.918 −10.243 1.00 16.61 C ATOM 388 O GLY D 385 −40.267 −43.218 −11.462 1.00 15.88 O ATOM 389 N TYR D 386 −41.232 −42.424 −9.553 1.00 13.80 N ATOM 390 CA TYR D 386 −42.472 −42.005 −10.233 1.00 16.51 C ATOM 391 CB TYR D 386 −43.683 −42.863 −9.768 1.00 13.91 C ATOM 392 CG TYR D 386 −43.611 −44.357 −10.112 1.00 14.66 C ATOM 393 CD1 TYR D 386 −44.196 −44.849 −11.288 1.00 12.37 C ATOM 394 CE1 TYR D 386 −44.139 −46.200 −11.605 1.00 13.28 C ATOM 395 CZ TYR D 386 −43.497 −47.092 −10.741 1.00 13.00 C ATOM 396 OH TYR D 386 −43.452 −48.430 −11.098 1.00 11.38 O ATOM 397 CE2 TYR D 386 −42.920 −46.641 −9.560 1.00 12.98 C ATOM 398 CD2 TYR D 386 −42.996 −45.285 −9.240 1.00 14.44 C ATOM 399 C TYR D 386 −42.780 −40.514 −9.987 1.00 16.12 C ATOM 400 O TYR D 386 −42.433 −39.953 −8.966 1.00 12.28 O ATOM 401 N ALA D 387 −43.482 −39.911 −10.927 1.00 16.31 N ATOM 402 CA ALA D 387 −43.942 −38.564 −10.808 1.00 14.82 C ATOM 403 CB ALA D 387 −43.564 −37.771 −12.076 1.00 14.59 C ATOM 404 C ALA D 387 −45.449 −38.707 −10.713 1.00 18.68 C ATOM 405 O ALA D 387 −46.016 −39.750 −11.110 1.00 15.78 O ATOM 406 N TRP D 388 −46.105 −37.673 −10.221 1.00 14.36 N ATOM 407 CA TRP D 388 −47.556 −37.721 −10.006 1.00 16.10 C ATOM 408 CB TRP D 388 −47.877 −37.612 −8.527 1.00 13.99 C ATOM 409 CG TRP D 388 −47.227 −36.455 −7.832 1.00 14.45 C ATOM 410 CD1 TRP D 388 −46.022 −36.447 −7.136 1.00 14.72 C ATOM 411 NE1 TRP D 388 −45.768 −35.170 −6.630 1.00 13.85 N ATOM 412 CE2 TRP D 388 −46.765 −34.311 −6.977 1.00 14.16 C ATOM 413 CD2 TRP D 388 −47.734 −35.065 −7.760 1.00 12.99 C ATOM 414 CE3 TRP D 388 −48.885 −34.416 −8.231 1.00 13.59 C ATOM 415 CZ3 TRP D 388 −49.045 −33.030 −7.951 1.00 22.02 C ATOM 416 CH2 TRP D 388 −48.091 −32.315 −7.212 1.00 17.37 C ATOM 417 CZ2 TRP D 388 −46.936 −32.936 −6.695 1.00 17.87 C ATOM 418 C TRP D 388 −48.293 −36.667 −10.780 1.00 16.70 C ATOM 419 O TRP D 388 −47.760 −35.579 −11.058 1.00 15.47 O ATOM 420 N THR D 389 −49.517 −36.994 −11.168 1.00 15.71 N ATOM 421 CA THR D 389 −50.413 −36.016 −11.793 1.00 17.50 C ATOM 422 CB THR D 389 −50.614 −36.319 −13.315 1.00 17.16 C ATOM 423 OG1 THR D 389 −49.345 −36.323 −13.949 1.00 17.93 O ATOM 424 CG2 THR D 389 −51.453 −35.261 −13.992 1.00 14.92 C ATOM 425 C THR D 389 −51.747 −36.120 −11.055 1.00 16.97 C ATOM 426 O THR D 389 −52.271 −37.225 −10.892 1.00 14.38 O ATOM 427 N ILE D 390 −52.313 −34.986 −10.647 1.00 13.44 N ATOM 428 CA ILE D 390 −53.672 −35.024 −9.996 1.00 13.01 C ATOM 429 CB ILE D 390 −54.094 −33.589 −9.577 1.00 15.37 C ATOM 430 CG1 ILE D 390 −53.148 −33.081 −8.496 1.00 21.58 C ATOM 431 CD1 ILE D 390 −53.299 −31.578 −8.181 1.00 28.38 C ATOM 432 CG2 ILE D 390 −55.555 −33.551 −9.123 1.00 16.44 C ATOM 433 C ILE D 390 −54.715 −35.631 −10.917 1.00 12.38 C ATOM 434 O ILE D 390 −54.710 −35.330 −12.155 1.00 12.79 O ATOM 435 N ALA D 391 −55.601 −36.476 −10.338 1.00 11.93 N ATOM 436 CA ALA D 391 −56.627 −37.195 −11.067 1.00 13.20 C ATOM 437 CB ALA D 391 −56.324 −38.720 −11.053 1.00 13.08 C ATOM 438 C ALA D 391 −57.986 −36.940 −10.425 1.00 14.34 C ATOM 439 O ALA D 391 −58.203 −37.218 −9.229 1.00 13.65 O ATOM 440 N GLN D 392 −58.903 −36.405 −11.196 1.00 13.27 N ATOM 441 CA GLN D 392 −60.202 −36.125 −10.636 1.00 14.78 C ATOM 442 CB GLN D 392 −60.417 −34.603 −10.536 1.00 19.61 C ATOM 443 CG GLN D 392 −60.409 −33.910 −11.873 1.00 19.31 C ATOM 444 CD GLN D 392 −60.611 −32.399 −11.720 1.00 28.10 C ATOM 445 OE1 GLN D 392 −59.922 −31.739 −10.936 1.00 22.08 O ATOM 446 NE2 GLN D 392 −61.533 −31.853 −12.494 1.00 18.99 N ATOM 447 C GLN D 392 −61.331 −36.757 −11.443 1.00 13.09 C ATOM 448 O GLN D 392 −61.203 −37.004 −12.666 1.00 10.48 O ATOM 449 N CYS D 393 −62.439 −37.022 −10.761 1.00 12.28 N ATOM 450 CA CYS D 393 −63.614 −37.677 −11.380 1.00 10.15 C ATOM 451 CB CYS D 393 −64.750 −37.834 −10.342 1.00 10.86 C ATOM 452 SG CYS D 393 −66.264 −38.512 −11.101 1.00 13.50 S ATOM 453 C CYS D 393 −64.112 −36.828 −12.553 1.00 11.97 C ATOM 454 O CYS D 393 −64.240 −35.579 −12.403 1.00 11.58 O ATOM 455 N LYS D 394 −64.314 −37.462 −13.719 1.00 11.31 N ATOM 456 CA LYS D 394 −64.747 −36.758 −14.945 1.00 12.98 C ATOM 457 CB LYS D 394 −64.691 −37.695 −16.154 1.00 15.77 C ATOM 458 CG LYS D 394 −65.781 −38.795 −16.224 1.00 13.41 C ATOM 459 CD LYS D 394 −65.790 −39.401 −17.643 1.00 15.91 C ATOM 460 CE LYS D 394 −67.089 −40.162 −17.963 1.00 19.30 C ATOM 461 NZ LYS D 394 −66.792 −41.211 −19.000 1.00 22.82 N ATOM 462 C LYS D 394 −66.148 −36.182 −14.810 1.00 12.21 C ATOM 463 O LYS D 394 −66.501 −35.251 −15.512 1.00 10.78 O ATOM 464 N ILE D 395 −66.967 −36.770 −13.931 1.00 10.39 N ATOM 465 CA ILE D 395 −68.327 −36.251 −13.732 1.00 12.82 C ATOM 466 CB ILE D 395 −69.330 −37.377 −13.326 1.00 15.03 C ATOM 467 CG1 ILE D 395 −69.500 −38.462 −14.442 1.00 12.89 C ATOM 468 CD1 ILE D 395 −69.999 −37.977 −15.819 1.00 18.63 C ATOM 469 CG2 ILE D 395 −70.661 −36.774 −12.855 1.00 12.67 C ATOM 470 C ILE D 395 −68.430 −35.072 −12.695 1.00 15.23 C ATOM 471 O ILE D 395 −69.015 −33.986 −13.011 1.00 14.48 O ATOM 472 N CYS D 396 −67.884 −35.266 −11.474 1.00 11.74 N ATOM 473 CA CYS D 396 −68.110 −34.286 −10.406 1.00 12.31 C ATOM 474 CB CYS D 396 −68.708 −34.950 −9.180 1.00 14.41 C ATOM 475 SG CYS D 396 −67.536 −36.079 −8.380 1.00 13.68 S ATOM 476 C CYS D 396 −66.887 −33.466 −10.025 1.00 14.18 C ATOM 477 O CYS D 396 −66.975 −32.588 −9.143 1.00 14.91 O ATOM 478 N ALA D 397 −65.780 −33.744 −10.717 1.00 13.71 N ATOM 479 CA ALA D 397 −64.472 −33.122 −10.494 1.00 13.23 C ATOM 480 CB ALA D 397 −64.498 −31.612 −10.832 1.00 16.60 C ATOM 481 C ALA D 397 −63.880 −33.379 −9.085 1.00 12.71 C ATOM 482 O ALA D 397 −62.928 −32.715 −8.714 1.00 13.85 O ATOM 483 N SER D 398 −64.412 −34.346 −8.317 1.00 10.48 N ATOM 484 CA SER D 398 −63.847 −34.664 −7.006 1.00 12.91 C ATOM 485 CB SER D 398 −64.680 −35.706 −6.236 1.00 15.08 C ATOM 486 OG SER D 398 −66.017 −35.188 −6.062 1.00 17.86 O ATOM 487 C SER D 398 −62.489 −35.201 −7.239 1.00 16.45 C ATOM 488 O SER D 398 −62.288 −36.017 −8.163 1.00 15.23 O ATOM 489 N HIS D 399 −61.547 −34.791 −6.398 1.00 16.26 N ATOM 490 CA HIS D 399 −60.148 −35.277 −6.523 1.00 20.34 C ATOM 491 CB HIS D 399 −59.169 −34.342 −5.772 1.00 28.30 C ATOM 492 CG HIS D 399 −58.841 −33.039 −6.510 1.00 38.19 C ATOM 493 ND1 HIS D 399 −59.751 −32.360 −7.256 1.00 45.02 N ATOM 494 CE1 HIS D 399 −59.171 −31.243 −7.762 1.00 36.88 C ATOM 495 NE2 HIS D 399 −57.900 −31.193 −7.320 1.00 35.80 N ATOM 496 CD2 HIS D 399 −57.661 −32.274 −6.545 1.00 37.39 C ATOM 497 C HIS D 399 −60.058 −36.672 −5.984 1.00 18.25 C ATOM 498 O HIS D 399 −60.261 −36.897 −4.795 1.00 22.04 O ATOM 499 N ILE D 400 −59.807 −37.652 −6.844 1.00 18.94 N ATOM 500 CA ILE D 400 −59.835 −39.041 −6.370 1.00 14.15 C ATOM 501 CB ILE D 400 −60.411 −40.039 −7.429 1.00 14.33 C ATOM 502 CG1 ILE D 400 −61.800 −39.564 −7.918 1.00 20.52 C ATOM 503 CD1 ILE D 400 −62.771 −39.184 −6.830 1.00 17.91 C ATOM 504 CG2 ILE D 400 −60.253 −41.458 −6.822 1.00 13.75 C ATOM 505 C ILE D 400 −58.439 −39.507 −5.949 1.00 12.55 C ATOM 506 O ILE D 400 −58.318 −40.312 −5.034 1.00 14.22 O ATOM 507 N GLY D 401 −57.400 −38.986 −6.612 1.00 11.62 N ATOM 508 CA GLY D 401 −56.030 −39.454 −6.402 1.00 11.50 C ATOM 509 C GLY D 401 −55.055 −38.874 −7.406 1.00 12.10 C ATOM 510 O GLY D 401 −55.165 −37.688 −7.809 1.00 13.31 O ATOM 511 N TRP D 402 −54.118 −39.721 −7.845 1.00 12.21 N ATOM 512 CA TRP D 402 −53.027 −39.284 −8.747 1.00 14.33 C ATOM 513 CB TRP D 402 −51.753 −38.930 −7.924 1.00 12.12 C ATOM 514 CG TRP D 402 −52.026 −37.893 −6.859 1.00 14.51 C ATOM 515 CD1 TRP D 402 −51.772 −36.518 −6.936 1.00 12.75 C ATOM 516 NE1 TRP D 402 −52.190 −35.887 −5.783 1.00 16.72 N ATOM 517 CE2 TRP D 402 −52.682 −36.794 −4.882 1.00 16.89 C ATOM 518 CD2 TRP D 402 −52.590 −38.114 −5.510 1.00 16.55 C ATOM 519 CE3 TRP D 402 −53.058 −39.239 −4.804 1.00 14.20 C ATOM 520 CZ3 TRP D 402 −53.570 −39.052 −3.492 1.00 17.10 C ATOM 521 CH2 TRP D 402 −53.665 −37.760 −2.904 1.00 17.46 C ATOM 522 CZ2 TRP D 402 −53.214 −36.613 −3.574 1.00 16.25 C ATOM 523 C TRP D 402 −52.688 −40.398 −9.686 1.00 14.30 C ATOM 524 O TRP D 402 −52.759 −41.616 −9.317 1.00 13.52 O ATOM 525 N LYS D 403 −52.320 −40.026 −10.902 1.00 13.72 N ATOM 526 CA LYS D 403 −51.659 −40.951 −11.795 1.00 13.75 C ATOM 527 CB LYS D 403 −51.870 −40.567 −13.260 1.00 13.23 C ATOM 528 CG LYS D 403 −51.555 −41.728 −14.207 1.00 17.06 C ATOM 529 CD LYS D 403 −51.597 −41.281 −15.667 1.00 21.80 C ATOM 530 CE LYS D 403 −51.571 −42.491 −16.614 1.00 24.70 C ATOM 531 NZ LYS D 403 −51.547 −41.943 −17.977 1.00 32.68 N ATOM 532 C LYS D 403 −50.168 −40.918 −11.501 1.00 19.68 C ATOM 533 O LYS D 403 −49.583 −39.824 −11.444 1.00 17.80 O ATOM 534 N PHE D 404 −49.551 −42.101 −11.339 1.00 12.41 N ATOM 535 CA PHE D 404 −48.106 −42.191 −11.158 1.00 12.80 C ATOM 536 CB PHE D 404 −47.786 −43.092 −9.972 1.00 10.89 C ATOM 537 CG PHE D 404 −48.022 −42.397 −8.646 1.00 14.98 C ATOM 538 CD1 PHE D 404 −47.022 −41.571 −8.097 1.00 11.97 C ATOM 539 CE1 PHE D 404 −47.255 −40.840 −6.933 1.00 13.58 C ATOM 540 CZ PHE D 404 −48.465 −40.954 −6.274 1.00 12.79 C ATOM 541 CE2 PHE D 404 −49.477 −41.760 −6.780 1.00 11.25 C ATOM 542 CD2 PHE D 404 −49.259 −42.493 −7.983 1.00 12.73 C ATOM 543 C PHE D 404 −47.448 −42.693 −12.428 1.00 13.53 C ATOM 544 O PHE D 404 −47.875 −43.728 −12.981 1.00 11.57 O ATOM 545 N THR D 405 −46.451 −41.959 −12.914 1.00 14.12 N ATOM 546 CA THR D 405 −45.799 −42.277 −14.227 1.00 13.80 C ATOM 547 CB THR D 405 −46.046 −41.130 −15.278 1.00 14.98 C ATOM 548 OG1 THR D 405 −45.873 −39.869 −14.652 1.00 17.13 O ATOM 549 CG2 THR D 405 −47.504 −41.145 −15.785 1.00 14.03 C ATOM 550 C THR D 405 −44.296 −42.477 −14.002 1.00 15.75 C ATOM 551 O THR D 405 −43.697 −41.667 −13.306 1.00 16.13 O ATOM 552 N ALA D 406 −43.714 −43.602 −14.489 1.00 14.07 N ATOM 553 CA ALA D 406 −42.297 −43.939 −14.220 1.00 17.74 C ATOM 554 CB ALA D 406 −41.928 −45.309 −14.809 1.00 16.49 C ATOM 555 C ALA D 406 −41.399 −42.891 −14.831 1.00 19.95 C ATOM 556 O ALA D 406 −41.658 −42.438 −15.922 1.00 19.78 O ATOM 557 N THR D 407 −40.334 −42.519 −14.124 1.00 20.93 N ATOM 558 CA THR D 407 −39.333 −41.648 −14.700 1.00 25.90 C ATOM 559 CB THR D 407 −38.660 −40.737 −13.651 1.00 23.99 C ATOM 560 OG1 THR D 407 −38.099 −41.540 −12.591 1.00 29.96 O ATOM 561 CG2 THR D 407 −39.673 −39.751 −13.083 1.00 28.37 C ATOM 562 C THR D 407 −38.260 −42.403 −15.509 1.00 26.09 C ATOM 563 O THR D 407 −37.468 −41.774 −16.160 1.00 27.79 O ATOM 564 N LYS D 408 −38.242 −43.738 −15.452 1.00 23.82 N ATOM 565 CA LYS D 408 −37.262 −44.544 −16.225 1.00 33.72 C ATOM 566 CB LYS D 408 −36.107 −45.077 −15.338 1.00 27.05 C ATOM 567 CG LYS D 408 −35.019 −44.057 −14.975 1.00 34.91 C ATOM 568 CD LYS D 408 −35.351 −43.247 −13.721 1.00 53.00 C ATOM 569 CE LYS D 408 −34.497 −41.977 −13.588 1.00 58.35 C ATOM 570 NZ LYS D 408 −33.578 −42.012 −12.413 1.00 58.21 N ATOM 571 C LYS D 408 −37.949 −45.702 −16.946 1.00 31.36 C ATOM 572 O LYS D 408 −38.909 −46.274 −16.437 1.00 18.42 O ATOM 573 N LYS D 409 −37.424 −46.074 −18.110 1.00 20.95 N ATOM 574 CA LYS D 409 −38.009 −47.119 −18.897 1.00 24.98 C ATOM 575 CB LYS D 409 −37.386 −47.158 −20.322 1.00 24.45 C ATOM 576 CG LYS D 409 −37.767 −45.989 −21.216 1.00 42.36 C ATOM 577 CD LYS D 409 −39.167 −46.137 −21.778 1.00 43.75 C ATOM 578 CE LYS D 409 −39.283 −45.378 −23.091 1.00 57.30 C ATOM 579 NZ LYS D 409 −40.108 −46.142 −24.066 1.00 69.61 N ATOM 580 C LYS D 409 −37.973 −48.531 −18.282 1.00 19.48 C ATOM 581 O LYS D 409 −38.757 −49.382 −18.685 1.00 27.02 O ATOM 582 N ASP D 410 −37.043 −48.824 −17.388 1.00 25.16 N ATOM 583 CA ASP D 410 −36.886 −50.250 −16.999 1.00 33.61 C ATOM 584 CB ASP D 410 −35.421 −50.602 −16.754 1.00 43.22 C ATOM 585 CG ASP D 410 −34.850 −49.865 −15.585 1.00 41.26 C ATOM 586 OD1 ASP D 410 −35.440 −48.837 −15.200 1.00 52.35 O ATOM 587 OD2 ASP D 410 −33.829 −50.317 −15.028 1.00 55.02 O ATOM 588 C ASP D 410 −37.742 −50.647 −15.784 1.00 43.76 C ATOM 589 O ASP D 410 −37.664 −51.808 −15.311 1.00 34.74 O ATOM 590 N MET D 411 −38.525 −49.675 −15.271 1.00 27.98 N ATOM 591 CA MET D 411 −39.476 −49.906 −14.186 1.00 28.95 C ATOM 592 CB MET D 411 −39.822 −48.579 −13.502 1.00 19.24 C ATOM 593 CG MET D 411 −38.592 −48.060 −12.784 1.00 32.01 C ATOM 594 SD MET D 411 −38.948 −46.691 −11.714 1.00 43.30 S ATOM 595 CE MET D 411 −38.939 −45.425 −12.935 1.00 25.93 C ATOM 596 C MET D 411 −40.772 −50.599 −14.638 1.00 30.56 C ATOM 597 O MET D 411 −41.159 −50.510 −15.801 1.00 28.13 O ATOM 598 N SER D 412 −41.414 −51.308 −13.702 1.00 23.78 N ATOM 599 CA SER D 412 −42.721 −51.934 −13.933 1.00 19.87 C ATOM 600 CB SER D 412 −42.600 −53.434 −14.274 1.00 18.60 C ATOM 601 OG SER D 412 −41.819 −54.083 −13.274 1.00 25.54 O ATOM 602 C SER D 412 −43.535 −51.646 −12.681 1.00 17.08 C ATOM 603 O SER D 412 −43.016 −51.863 −11.582 1.00 15.66 O ATOM 604 N PRO D 413 −44.861 −51.558 −12.852 1.00 15.88 N ATOM 605 CA PRO D 413 −45.453 −50.858 −14.029 1.00 12.57 C ATOM 606 CB PRO D 413 −46.926 −50.750 −13.630 1.00 13.13 C ATOM 607 CG PRO D 413 −46.844 −50.396 −12.162 1.00 8.99 C ATOM 608 CD PRO D 413 −45.659 −51.266 −11.631 1.00 12.57 C ATOM 609 C PRO D 413 −44.849 −49.490 −14.460 1.00 12.70 C ATOM 610 O PRO D 413 −44.348 −48.745 −13.629 1.00 12.74 O ATOM 611 N GLN D 414 −44.905 −49.172 −15.743 1.00 10.28 N ATOM 612 CA GLN D 414 −44.562 −47.802 −16.203 1.00 11.82 C ATOM 613 CB GLN D 414 −44.552 −47.757 −17.762 1.00 13.32 C ATOM 614 CG GLN D 414 −43.277 −48.370 −18.366 1.00 16.28 C ATOM 615 CD GLN D 414 −42.056 −47.572 −17.976 1.00 19.40 C ATOM 616 OE1 GLN D 414 −41.250 −48.002 −17.155 1.00 22.54 O ATOM 617 NE2 GLN D 414 −41.952 −46.386 −18.501 1.00 13.79 N ATOM 618 C GLN D 414 −45.533 −46.726 −15.666 1.00 11.67 C ATOM 619 O GLN D 414 −45.207 −45.520 −15.620 1.00 15.09 O ATOM 620 N LYS D 415 −46.754 −47.130 −15.364 1.00 10.81 N ATOM 621 CA LYS D 415 −47.663 −46.251 −14.656 1.00 14.56 C ATOM 622 CB LYS D 415 −48.381 −45.281 −15.649 1.00 15.93 C ATOM 623 CG LYS D 415 −49.558 −45.883 −16.417 1.00 18.43 C ATOM 624 CD LYS D 415 −49.107 −46.989 −17.348 1.00 26.76 C ATOM 625 CE LYS D 415 −49.854 −47.053 −18.695 1.00 22.81 C ATOM 626 NZ LYS D 415 −49.364 −48.250 −19.424 1.00 20.62 N ATOM 627 C LYS D 415 −48.647 −47.035 −13.794 1.00 11.11 C ATOM 628 O LYS D 415 −48.846 −48.258 −13.999 1.00 9.89 O ATOM 629 N PHE D 416 −49.249 −46.341 −12.818 1.00 9.25 N ATOM 630 CA PHE D 416 −50.319 −46.902 −12.020 1.00 9.48 C ATOM 631 CB PHE D 416 −49.781 −47.812 −10.895 1.00 10.39 C ATOM 632 CG PHE D 416 −48.910 −47.103 −9.895 1.00 9.70 C ATOM 633 CD1 PHE D 416 −49.411 −46.683 −8.672 1.00 10.81 C ATOM 634 CE1 PHE D 416 −48.610 −46.062 −7.727 1.00 12.49 C ATOM 635 CZ PHE D 416 −47.272 −45.869 −7.985 1.00 11.76 C ATOM 636 CE2 PHE D 416 −46.738 −46.297 −9.188 1.00 9.84 C ATOM 637 CD2 PHE D 416 −47.536 −46.917 −10.148 1.00 11.10 C ATOM 638 C PHE D 416 −51.095 −45.738 −11.426 1.00 9.90 C ATOM 639 O PHE D 416 −50.799 −44.596 −11.692 1.00 11.81 O ATOM 640 N TRP D 417 −52.096 −46.037 −10.622 1.00 8.82 N ATOM 641 CA TRP D 417 −52.835 −44.966 −9.969 1.00 10.98 C ATOM 642 CB TRP D 417 −54.311 −45.065 −10.401 1.00 11.08 C ATOM 643 CG TRP D 417 −54.486 −44.973 −11.903 1.00 11.12 C ATOM 644 CD1 TRP D 417 −54.392 −45.999 −12.841 1.00 11.61 C ATOM 645 NE1 TRP D 417 −54.629 −45.508 −14.126 1.00 11.51 N ATOM 646 CE2 TRP D 417 −54.863 −44.187 −14.086 1.00 12.88 C ATOM 647 CD2 TRP D 417 −54.789 −43.769 −12.681 1.00 11.63 C ATOM 648 CE3 TRP D 417 −54.989 −42.423 −12.360 1.00 13.96 C ATOM 649 CZ3 TRP D 417 −55.227 −41.520 −13.420 1.00 13.17 C ATOM 650 CH2 TRP D 417 −55.320 −41.968 −14.759 1.00 15.26 C ATOM 651 CZ2 TRP D 417 −55.142 −43.305 −15.102 1.00 15.07 C ATOM 652 C TRP D 417 −52.765 −45.116 −8.475 1.00 8.85 C ATOM 653 O TRP D 417 −52.977 −46.224 −7.963 1.00 8.82 O ATOM 654 N GLY D 418 −52.638 −44.012 −7.748 1.00 8.91 N ATOM 655 CA GLY D 418 −52.798 −44.115 −6.286 1.00 10.88 C ATOM 656 C GLY D 418 −54.085 −43.340 −5.919 1.00 11.70 C ATOM 657 O GLY D 418 −54.182 −42.151 −6.214 1.00 12.23 O ATOM 658 N LEU D 419 −55.065 −44.020 −5.328 1.00 12.48 N ATOM 659 CA LEU D 419 −56.418 −43.452 −5.157 1.00 9.88 C ATOM 660 CB LEU D 419 −57.482 −44.334 −5.877 1.00 11.17 C ATOM 661 CG LEU D 419 −57.224 −44.649 −7.379 1.00 12.93 C ATOM 662 CD1 LEU D 419 −58.244 −45.652 −7.962 1.00 15.74 C ATOM 663 CD2 LEU D 419 −57.242 −43.342 −8.201 1.00 11.98 C ATOM 664 C LEU D 419 −56.701 −43.366 −3.656 1.00 10.95 C ATOM 665 O LEU D 419 −56.374 −44.288 −2.891 1.00 12.49 O ATOM 666 N THR D 420 −57.225 −42.229 −3.227 1.00 12.35 N ATOM 667 CA THR D 420 −57.615 −42.012 −1.806 1.00 14.78 C ATOM 668 CB THR D 420 −57.917 −40.511 −1.607 1.00 17.24 C ATOM 669 OG1 THR D 420 −56.748 −39.799 −2.020 1.00 14.00 O ATOM 670 CG2 THR D 420 −58.311 −40.158 −0.098 1.00 13.66 C ATOM 671 C THR D 420 −58.834 −42.877 −1.508 1.00 14.19 C ATOM 672 O THR D 420 −59.866 −42.733 −2.161 1.00 13.73 O ATOM 673 N ARG D 421 −58.679 −43.852 −0.602 1.00 12.36 N ATOM 674 CA ARG D 421 −59.736 −44.849 −0.345 1.00 17.09 C ATOM 675 CB ARG D 421 −59.353 −45.826 0.790 1.00 22.23 C ATOM 676 CG ARG D 421 −58.414 −46.946 0.426 1.00 30.22 C ATOM 677 CD ARG D 421 −57.848 −47.604 1.715 1.00 30.57 C ATOM 678 NE ARG D 421 −56.626 −48.369 1.444 1.00 36.36 N ATOM 679 CZ ARG D 421 −56.620 −49.592 0.910 1.00 44.87 C ATOM 680 NH1 ARG D 421 −57.772 −50.188 0.593 1.00 51.21 N ATOM 681 NH2 ARG D 421 −55.470 −50.222 0.690 1.00 40.12 N ATOM 682 C ARG D 421 −61.024 −44.213 0.083 1.00 16.52 C ATOM 683 O ARG D 421 −62.096 −44.713 −0.251 1.00 14.73 O ATOM 684 N SER D 422 −60.930 −43.143 0.874 1.00 12.14 N ATOM 685 CA SER D 422 −62.167 −42.530 1.408 1.00 16.31 C ATOM 686 CB SER D 422 −61.834 −41.558 2.561 1.00 20.51 C ATOM 687 OG SER D 422 −60.991 −40.527 2.063 1.00 15.45 O ATOM 688 C SER D 422 −62.939 −41.789 0.322 1.00 15.91 C ATOM 689 O SER D 422 −64.092 −41.374 0.533 1.00 13.62 O ATOM 690 N ALA D 423 −62.307 −41.600 −0.841 1.00 13.42 N ATOM 691 CA ALA D 423 −62.986 −40.952 −1.978 1.00 13.14 C ATOM 692 CB ALA D 423 −61.980 −40.216 −2.838 1.00 12.90 C ATOM 693 C ALA D 423 −63.752 −41.963 −2.820 1.00 12.91 C ATOM 694 O ALA D 423 −64.359 −41.604 −3.822 1.00 12.81 O ATOM 695 N LEU D 424 −63.695 −43.246 −2.440 1.00 14.18 N ATOM 696 CA LEU D 424 −64.398 −44.308 −3.186 1.00 11.87 C ATOM 697 CB LEU D 424 −63.380 −45.343 −3.697 1.00 12.17 C ATOM 698 CG LEU D 424 −62.251 −44.765 −4.601 1.00 14.29 C ATOM 699 CD1 LEU D 424 −61.072 −45.768 −4.712 1.00 14.19 C ATOM 700 CD2 LEU D 424 −62.773 −44.377 −5.987 1.00 13.76 C ATOM 701 C LEU D 424 −65.467 −45.009 −2.327 1.00 13.48 C ATOM 702 O LEU D 424 −65.328 −45.088 −1.126 1.00 13.98 O ATOM 703 N LEU D 425 −66.460 −45.617 −2.977 1.00 14.90 N ATOM 704 CA LEU D 425 −67.433 −46.462 −2.276 1.00 22.54 C ATOM 705 CB LEU D 425 −68.842 −45.890 −2.406 1.00 25.83 C ATOM 706 CG LEU D 425 −69.508 −45.054 −1.287 1.00 28.41 C ATOM 707 CD1 LEU D 425 −70.840 −44.603 −1.848 1.00 25.53 C ATOM 708 CD2 LEU D 425 −69.736 −45.900 −0.046 1.00 30.31 C ATOM 709 C LEU D 425 −67.367 −47.842 −2.919 1.00 25.71 C ATOM 710 O LEU D 425 −67.271 −47.894 −4.152 1.00 22.50 O ATOM 711 N PRO D 426 −67.775 −48.885 −2.159 1.00 33.18 N ATOM 712 CA PRO D 426 −67.053 −50.013 −1.618 1.00 48.92 C ATOM 713 CB PRO D 426 −67.388 −51.141 −2.594 1.00 41.81 C ATOM 714 CG PRO D 426 −68.695 −50.699 −3.246 1.00 43.68 C ATOM 715 CD PRO D 426 −69.083 −49.381 −2.616 1.00 43.50 C ATOM 716 C PRO D 426 −65.578 −49.716 −1.515 1.00 49.77 C ATOM 717 O PRO D 426 −65.226 −48.678 −0.959 1.00 40.20 O ATOM 718 N THR A 321 −54.675 −62.915 −3.216 1.00 36.85 N ATOM 719 CA THR A 321 −54.397 −62.908 −4.703 1.00 33.70 C ATOM 720 CB THR A 321 −55.257 −61.851 −5.445 1.00 33.79 C ATOM 721 OG1 THR A 321 −54.707 −60.531 −5.240 1.00 38.82 C ATOM 722 CG2 THR A 321 −56.731 −61.893 −4.983 1.00 47.72 C ATOM 723 C THR A 321 −52.899 −62.704 −5.079 1.00 27.23 C ATOM 724 O THR A 321 −52.533 −62.920 −6.229 1.00 22.14 O ATOM 725 N SER A 322 −52.070 −62.241 −4.134 1.00 18.61 N ATOM 726 CA SER A 322 −50.683 −61.830 −4.462 1.00 23.51 C ATOM 727 CB SER A 322 −50.059 −61.094 −3.272 1.00 24.88 C ATOM 728 OG SER A 322 −50.807 −59.930 −3.043 1.00 27.19 O ATOM 729 C SER A 322 −49.722 −62.967 −4.879 1.00 22.97 C ATOM 730 O SER A 322 −49.666 −64.008 −4.218 1.00 24.02 O ATOM 731 N LEU A 323 −48.928 −62.740 −5.932 1.00 15.40 N ATOM 732 CA LEU A 323 −47.818 −63.645 −6.258 1.00 13.14 C ATOM 733 CB LEU A 323 −47.912 −64.160 −7.706 1.00 14.81 C ATOM 734 CG LEU A 323 −49.188 −65.044 −7.954 1.00 15.73 C ATOM 735 CD1 LEU A 323 −49.508 −65.254 −9.423 1.00 21.00 C ATOM 736 CD2 LEU A 323 −49.098 −66.394 −7.248 1.00 20.79 C ATOM 737 C LEU A 323 −46.528 −62.901 −6.044 1.00 14.34 C ATOM 738 O LEU A 323 −46.253 −61.935 −6.750 1.00 13.90 O ATOM 739 N CYS A 324 −45.753 −63.356 −5.044 1.00 13.99 N ATOM 740 CA CYS A 324 −44.564 −62.669 −4.600 1.00 16.60 C ATOM 741 CB CYS A 324 −44.591 −62.550 −3.052 1.00 16.43 C ATOM 742 SG CYS A 324 −45.903 −61.421 −2.455 1.00 20.16 S ATOM 743 C CYS A 324 −43.303 −63.409 −5.072 1.00 13.72 C ATOM 744 O CYS A 324 −43.348 −64.620 −5.320 1.00 13.21 O ATOM 745 N CYS A 325 −42.196 −62.669 −5.207 1.00 13.65 N ATOM 746 CA CYS A 325 −40.893 −63.235 −5.425 1.00 13.55 C ATOM 747 CB CYS A 325 −39.805 −62.154 −5.330 1.00 16.01 C ATOM 748 SG CYS A 325 −38.111 −62.791 −5.478 1.00 16.92 S ATOM 749 C CYS A 325 −40.624 −64.313 −4.377 1.00 12.56 C ATOM 750 O CYS A 325 −40.712 −64.079 −3.191 1.00 13.54 O ATOM 751 N LYS A 326 −40.308 −65.501 −4.818 1.00 12.78 N ATOM 752 CA LYS A 326 −40.080 −66.574 −3.869 1.00 13.61 C ATOM 753 CB LYS A 326 −40.075 −67.933 −4.601 1.00 16.71 C ATOM 754 CG LYS A 326 −40.005 −69.119 −3.623 1.00 20.49 C ATOM 755 CD LYS A 326 −40.928 −70.266 −4.045 1.00 24.76 C ATOM 756 CE LYS A 326 −40.134 −71.373 −4.660 1.00 27.96 C ATOM 757 NZ LYS A 326 −40.985 −72.307 −5.455 1.00 36.68 N ATOM 758 C LYS A 326 −38.784 −66.389 −3.042 1.00 13.57 C ATOM 759 O LYS A 326 −38.703 −66.815 −1.860 1.00 14.01 O ATOM 760 N GLN A 327 −37.757 −65.810 −3.676 1.00 14.76 N ATOM 761 CA GLN A 327 −36.497 −65.614 −3.027 1.00 17.02 C ATOM 762 CB GLN A 327 −35.411 −65.233 −4.034 1.00 17.41 C ATOM 763 CG GLN A 327 −34.077 −64.947 −3.352 1.00 15.71 C ATOM 764 CD GLN A 327 −32.976 −64.766 −4.348 1.00 21.33 C ATOM 765 OE1 GLN A 327 −33.053 −65.294 −5.440 1.00 20.60 O ATOM 766 NE2 GLN A 327 −31.943 −64.019 −3.983 1.00 19.63 N ATOM 767 C GLN A 327 −36.585 −64.580 −1.883 1.00 14.71 C ATOM 768 O GLN A 327 −36.260 −64.910 −0.742 1.00 12.39 O ATOM 769 N CYS A 328 −37.033 −63.346 −2.177 1.00 13.05 N ATOM 770 CA CYS A 328 −37.057 −62.319 −1.133 1.00 12.85 C ATOM 771 CB CYS A 328 −36.652 −60.933 −1.667 1.00 10.68 C ATOM 772 SG CYS A 328 −37.896 −60.256 −2.776 1.00 14.55 S ATOM 773 C CYS A 328 −38.430 −62.273 −0.374 1.00 14.31 C ATOM 774 O CYS A 328 −38.576 −61.541 0.619 1.00 13.89 O ATOM 775 N GLN A 329 −39.426 −63.029 −0.862 1.00 15.72 N ATOM 776 CA GLN A 329 −40.730 −63.255 −0.139 1.00 15.02 C ATOM 777 CB GLN A 329 −40.515 −63.846 1.270 1.00 14.54 C ATOM 778 CG GLN A 329 −39.514 −65.025 1.259 1.00 18.55 C ATOM 779 CD GLN A 329 −39.554 −65.872 2.516 1.00 20.90 C ATOM 780 OE1 GLN A 329 −39.833 −67.056 2.457 1.00 19.96 O ATOM 781 NE2 GLN A 329 −39.276 −65.264 3.657 1.00 15.75 N ATOM 782 C GLN A 329 −41.701 −62.091 −0.045 1.00 19.78 C ATOM 783 O GLN A 329 −42.900 −62.278 −0.187 1.00 22.09 O ATOM 784 N GLU A 330 −41.186 −60.904 0.206 1.00 16.66 N ATOM 785 CA GLU A 330 −41.989 −59.773 0.570 1.00 19.80 C ATOM 786 CB GLU A 330 −41.181 −58.860 1.476 1.00 21.82 C ATOM 787 CG GLU A 330 −40.763 −59.534 2.772 1.00 30.49 C ATOM 788 CD GLU A 330 −41.918 −60.221 3.470 1.00 42.30 C ATOM 789 OE1 GLU A 330 −41.888 −61.474 3.606 1.00 59.27 O ATOM 790 OE2 GLU A 330 −42.857 −59.501 3.878 1.00 47.44 O ATOM 791 C GLU A 330 −42.464 −58.970 −0.662 1.00 25.10 C ATOM 792 O GLU A 330 −43.399 −58.175 −0.554 1.00 19.27 O ATOM 793 N THR A 331 −41.808 −59.190 −1.807 1.00 15.88 N ATOM 794 CA THR A 331 −41.965 −58.341 −2.958 1.00 16.40 C ATOM 795 CB THR A 331 −40.612 −58.191 −3.701 1.00 16.06 C ATOM 796 OG1 THR A 331 −39.677 −57.571 −2.812 1.00 16.10 O ATOM 797 CG2 THR A 331 −40.751 −57.282 −4.997 1.00 15.45 C ATOM 798 C THR A 331 −43.023 −58.935 −3.880 1.00 17.58 C ATOM 799 O THR A 331 −42.834 −60.040 −4.420 1.00 12.69 O ATOM 800 N GLU A 332 −44.138 −58.218 −4.048 1.00 14.65 N ATOM 801 CA GLU A 332 −45.223 −58.692 −4.969 1.00 14.25 C ATOM 802 CB GLU A 332 −46.583 −57.979 −4.685 1.00 12.96 C ATOM 803 CG GLU A 332 −47.698 −58.473 −5.599 1.00 13.58 C ATOM 804 CD GLU A 332 −49.044 −57.755 −5.360 1.00 15.93 C ATOM 805 OE1 GLU A 332 −49.720 −58.044 −4.354 1.00 14.18 O ATOM 806 OE2 GLU A 332 −49.399 −56.882 −6.170 1.00 16.23 O ATOM 807 C GLU A 332 −44.813 −58.519 −6.423 1.00 12.55 C ATOM 808 O GLU A 332 −44.369 −57.446 −6.785 1.00 18.26 O ATOM 809 N ILE A 333 −44.971 −59.569 −7.248 1.00 11.77 N ATOM 810 CA ILE A 333 −44.617 −59.488 −8.682 1.00 12.66 C ATOM 811 CB ILE A 333 −43.724 −60.681 −9.143 1.00 12.54 C ATOM 812 CG1 ILE A 333 −42.439 −60.800 −8.262 1.00 11.27 C ATOM 813 CD1 ILE A 333 −41.594 −59.510 −8.215 1.00 15.65 C ATOM 814 CG2 ILE A 333 −43.337 −60.517 −10.620 1.00 10.92 C ATOM 815 C ILE A 333 −45.850 −59.349 −9.581 1.00 13.02 C ATOM 816 O ILE A 333 −45.856 −58.590 −10.548 1.00 16.03 O ATOM 817 N THR A 334 −46.917 −60.043 −9.220 1.00 11.83 N ATOM 818 CA THR A 334 −48.164 −59.925 −9.950 1.00 14.76 C ATOM 819 CB THR A 334 −48.082 −60.686 −11.310 1.00 14.72 C ATOM 820 OG1 THR A 334 −49.186 −60.308 −12.136 1.00 14.23 O ATOM 821 CG2 THR A 334 −48.057 −62.226 −11.112 1.00 15.10 C ATOM 822 C THR A 334 −49.328 −60.413 −9.053 1.00 12.35 C ATOM 823 O THR A 334 −49.129 −60.640 −7.848 1.00 15.14 O ATOM 824 N THR A 335 −50.534 −60.535 −9.621 1.00 12.76 N ATOM 825 CA THR A 335 −51.662 −61.054 −8.867 1.00 13.14 C ATOM 826 CB THR A 335 −52.692 −59.967 −8.437 1.00 14.35 C ATOM 827 OG1 THR A 335 −53.497 −59.558 −9.575 1.00 12.57 O ATOM 828 CG2 THR A 335 −51.994 −58.788 −7.779 1.00 15.81 C ATOM 829 C THR A 335 −52.364 −62.035 −9.762 1.00 11.61 C ATOM 830 O THR A 335 −52.243 −61.959 −10.963 1.00 13.44 O ATOM 831 N LYS A 336 −53.106 −62.947 −9.183 1.00 14.01 N ATOM 832 CA LYS A 336 −53.911 −63.897 −9.953 1.00 14.50 C ATOM 833 CB LYS A 336 −54.656 −64.854 −9.014 1.00 19.90 C ATOM 834 CG LYS A 336 −53.720 −65.873 −8.361 1.00 26.48 C ATOM 835 CD LYS A 336 −54.439 −66.632 −7.243 1.00 32.77 C ATOM 836 CE LYS A 336 −53.882 −68.024 −7.019 1.00 39.91 C ATOM 837 NZ LYS A 336 −54.353 −68.537 −5.695 1.00 36.31 N ATOM 838 C LYS A 336 −54.909 −63.230 −10.836 1.00 17.46 C ATOM 839 O LYS A 336 −55.318 −63.807 −11.837 1.00 13.79 O ATOM 840 N ASN A 337 −55.311 −62.009 −10.488 1.00 13.63 N ATOM 841 CA ASN A 337 −56.242 −61.259 −11.353 1.00 13.98 C ATOM 842 CB ASN A 337 −56.684 −59.930 −10.701 1.00 16.05 C ATOM 843 CG ASN A 337 −57.407 −60.156 −9.362 1.00 20.84 C ATOM 844 OD1 ASN A 337 −57.010 −59.636 −8.335 1.00 24.54 O ATOM 845 ND2 ASN A 337 −58.441 −60.958 −9.387 1.00 26.88 N ATOM 846 C ASN A 337 −55.651 −60.957 −12.703 1.00 13.05 C ATOM 847 O ASN A 337 −56.401 −60.739 −13.667 1.00 13.64 O ATOM 848 N GLU A 338 −54.323 −60.936 −12.794 1.00 11.64 N ATOM 849 CA GLU A 338 −53.629 −60.552 −14.110 1.00 15.66 C ATOM 850 CB GLU A 338 −52.310 −59.784 −13.870 1.00 13.78 C ATOM 851 CG GLU A 338 −52.500 −58.495 −13.043 1.00 16.21 C ATOM 852 CD GLU A 338 −53.585 −57.598 −13.601 1.00 14.33 C ATOM 853 OE1 GLU A 338 −53.554 −57.273 −14.787 1.00 15.02 O ATOM 854 OE2 GLU A 338 −54.471 −57.182 −12.835 1.00 26.40 O ATOM 855 C GLU A 338 −53.404 −61.709 −15.088 1.00 12.62 C ATOM 856 O GLU A 338 −53.037 −61.510 −16.266 1.00 13.51 O ATOM 857 N ILE A 339 −53.714 −62.906 −14.620 1.00 14.65 N ATOM 858 CA ILE A 339 −53.491 −64.117 −15.398 1.00 16.57 C ATOM 859 CB ILE A 339 −53.714 −65.420 −14.538 1.00 15.59 C ATOM 860 CG1 ILE A 339 −52.624 −65.560 −13.490 1.00 19.56 C ATOM 861 CD1 ILE A 339 −53.024 −66.465 −12.337 1.00 22.71 C ATOM 862 CG2 ILE A 339 −53.696 −66.687 −15.429 1.00 15.60 C ATOM 863 C ILE A 339 −54.389 −64.105 −16.635 1.00 15.12 C ATOM 864 O ILE A 339 −55.655 −63.807 −16.577 1.00 11.90 O ATOM 865 N PHE A 340 −53.769 −64.397 −17.786 1.00 15.90 N ATOM 866 CA PHE A 340 −54.581 −64.653 −18.999 1.00 14.56 C ATOM 867 CB PHE A 340 −54.710 −63.384 −19.879 1.00 14.02 C ATOM 868 CG PHE A 340 −53.483 −63.084 −20.674 1.00 13.78 C ATOM 869 CD1 PHE A 340 −53.437 −63.369 −22.033 1.00 15.21 C ATOM 870 CE1 PHE A 340 −52.284 −63.136 −22.770 1.00 15.91 C ATOM 871 CZ PHE A 340 −51.160 −62.574 −22.143 1.00 13.81 C ATOM 872 CE2 PHE A 340 −51.196 −62.263 −20.783 1.00 13.46 C ATOM 873 CD2 PHE A 340 −52.346 −62.506 −20.051 1.00 13.30 C ATOM 874 C PHE A 340 −53.995 −65.806 −19.810 1.00 20.90 C ATOM 875 O PHE A 340 −52.857 −66.238 −19.545 1.00 17.46 O ATOM 876 N SER A 341 −54.731 −66.248 −20.849 1.00 18.94 N ATOM 877 CA SER A 341 −54.293 −67.399 −21.636 1.00 21.94 C ATOM 878 CB SER A 341 −55.365 −68.482 −21.564 1.00 23.78 C ATOM 879 OG SER A 341 −54.825 −69.697 −21.998 1.00 38.10 O ATOM 880 C SER A 341 −53.938 −67.073 −23.114 1.00 20.34 C ATOM 881 O SER A 341 −54.829 −66.768 −23.912 1.00 16.51 O ATOM 882 N LEU A 342 −52.648 −67.163 −23.467 1.00 21.10 N ATOM 883 CA LEU A 342 −52.153 −66.752 −24.817 1.00 26.95 C ATOM 884 CB LEU A 342 −50.691 −66.195 −24.749 1.00 29.01 C ATOM 885 CG LEU A 342 −49.887 −65.440 −25.846 1.00 23.73 C ATOM 886 CD1 LEU A 342 −49.886 −66.097 −27.202 1.00 31.08 C ATOM 887 CD2 LEU A 342 −50.360 −63.992 −26.000 1.00 36.25 C ATOM 888 C LEU A 342 −52.314 −67.921 −25.814 1.00 40.02 C ATOM 889 O LEU A 342 −52.954 −67.757 −26.868 1.00 30.34 O ATOM 890 N SER A 343 −51.810 −69.117 −25.466 1.00 40.03 N ATOM 891 CA SER A 343 −52.131 −70.316 −26.283 1.00 58.91 C ATOM 892 CB SER A 343 −51.365 −71.595 −25.836 1.00 71.75 C ATOM 893 OG SER A 343 −51.146 −71.659 −24.432 1.00 52.52 O ATOM 894 C SER A 343 −53.655 −70.553 −26.438 1.00 57.13 C ATOM 895 O SER A 343 −54.284 −71.305 −25.691 1.00 46.48 O ATOM 896 N GLU A 360 −45.643 −74.374 −16.390 1.00 32.49 N ATOM 897 CA GLU A 360 −44.281 −73.886 −16.134 1.00 44.51 C ATOM 898 CB GLU A 360 −43.293 −74.490 −17.143 1.00 49.59 C ATOM 899 CG GLU A 360 −41.848 −73.979 −17.027 1.00 63.54 C ATOM 900 CD GLU A 360 −40.905 −74.941 −16.300 1.00 83.86 C ATOM 901 OE1 GLU A 360 −40.491 −74.620 −15.158 1.00 82.15 O ATOM 902 OE2 GLU A 360 −40.561 −76.006 −16.879 1.00 74.40 O ATOM 903 C GLU A 360 −44.179 −72.336 −16.160 1.00 45.72 C ATOM 904 O GLU A 360 −43.478 −71.744 −15.300 1.00 27.45 O ATOM 905 N THR A 361 −44.841 −71.714 −17.161 1.00 26.30 N ATOM 906 CA THR A 361 −44.734 −70.252 −17.442 1.00 23.56 C ATOM 907 CB THR A 361 −44.079 −69.944 −18.823 1.00 30.86 C ATOM 908 OG1 THR A 361 −42.711 −70.375 −18.825 1.00 39.56 O ATOM 909 CG2 THR A 361 −44.101 −68.468 −19.096 1.00 23.76 C ATOM 910 C THR A 361 −46.121 −69.588 −17.351 1.00 20.65 C ATOM 911 O THR A 361 −47.022 −69.889 −18.089 1.00 23.89 O ATOM 912 N LEU A 362 −46.282 −68.726 −16.385 1.00 19.26 N ATOM 913 CA LEU A 362 −47.532 −68.103 −16.127 1.00 17.14 C ATOM 914 CB LEU A 362 −47.576 −67.736 −14.619 1.00 18.46 C ATOM 915 CG LEU A 362 −48.853 −67.155 −14.042 1.00 25.29 C ATOM 916 CD1 LEU A 362 −49.979 −68.162 −14.175 1.00 27.14 C ATOM 917 CD2 LEU A 362 −48.657 −66.729 −12.582 1.00 21.45 C ATOM 918 C LEU A 362 −47.503 −66.834 −17.012 1.00 19.54 C ATOM 919 O LEU A 362 −46.512 −66.109 −17.011 1.00 19.91 O ATOM 920 N THR A 363 −48.573 −66.576 −17.758 1.00 16.23 N ATOM 921 CA THR A 363 −48.656 −65.321 −18.553 1.00 12.37 C ATOM 922 CB THR A 363 −49.024 −65.598 −20.021 1.00 15.86 C ATOM 923 OG1 THR A 363 −50.262 −66.335 −20.083 1.00 16.26 O ATOM 924 CG2 THR A 363 −47.946 −66.412 −20.692 1.00 14.26 C ATOM 925 C THR A 363 −49.625 −64.348 −17.890 1.00 13.81 C ATOM 926 O THR A 363 −50.767 −64.710 −17.544 1.00 14.48 O ATOM 927 N VAL A 364 −49.147 −63.136 −17.608 1.00 13.67 N ATOM 928 CA VAL A 364 −49.996 −62.123 −16.965 1.00 11.58 C ATOM 929 CB VAL A 364 −49.609 −61.876 −15.481 1.00 10.46 C ATOM 930 CG1 VAL A 364 −49.882 −63.113 −14.620 1.00 12.05 C ATOM 931 CG2 VAL A 364 −48.163 −61.360 −15.351 1.00 9.62 C ATOM 932 C VAL A 364 −49.922 −60.783 −17.745 1.00 14.58 C ATOM 933 O VAL A 364 −48.872 −60.454 −18.397 1.00 14.22 O ATOM 934 N TYR A 365 −51.018 −59.996 −17.691 1.00 14.02 N ATOM 935 CA TYR A 365 −51.040 −58.742 −18.430 1.00 12.36 C ATOM 936 CB TYR A 365 −52.453 −58.221 −18.480 1.00 10.79 C ATOM 937 CG TYR A 365 −53.413 −58.936 −19.425 1.00 12.06 C ATOM 938 CD1 TYR A 365 −53.169 −58.977 −20.809 1.00 9.91 C ATOM 939 CE1 TYR A 365 −54.065 −59.550 −21.682 1.00 12.14 C ATOM 940 CZ TYR A 365 −55.217 −60.134 −21.172 1.00 14.62 C ATOM 941 OH TYR A 365 −56.106 −60.737 −22.053 1.00 18.44 O ATOM 942 CE2 TYR A 365 −55.485 −60.134 −19.805 1.00 12.56 C ATOM 943 CD2 TYR A 365 −54.571 −59.536 −18.931 1.00 11.47 C ATOM 944 C TYR A 365 −50.155 −57.660 −17.752 1.00 12.68 C ATOM 945 O TYR A 365 −49.651 −56.761 −18.401 1.00 13.36 O ATOM 946 N LYS A 366 −50.056 −57.718 −16.424 1.00 13.78 N ATOM 947 CA LYS A 366 −49.429 −56.657 −15.657 1.00 13.39 C ATOM 948 CB LYS A 366 −50.504 −55.745 −14.989 1.00 10.99 C ATOM 949 CG LYS A 366 −51.286 −54.841 −15.996 1.00 13.26 C ATOM 950 CD LYS A 366 −50.398 −53.644 −16.206 1.00 13.36 C ATOM 951 CE LYS A 366 −50.722 −52.698 −17.307 1.00 26.30 C ATOM 952 NZ LYS A 366 −49.661 −51.630 −17.091 1.00 18.54 N ATOM 953 C LYS A 366 −48.563 −57.305 −14.583 1.00 12.66 C ATOM 954 O LYS A 366 −48.929 −58.361 −14.024 1.00 14.23 O ATOM 955 N ALA A 367 −47.462 −56.629 −14.242 1.00 12.60 N ATOM 956 CA ALA A 367 −46.569 −57.062 −13.141 1.00 13.11 C ATOM 957 CB ALA A 367 −45.498 −58.052 −13.657 1.00 11.85 C ATOM 958 C ALA A 367 −45.922 −55.850 −12.515 1.00 11.70 C ATOM 959 O ALA A 367 −45.972 −54.755 −13.090 1.00 15.34 O ATOM 960 N SER A 368 −45.309 −56.038 −11.337 1.00 13.49 N ATOM 961 CA SER A 368 −44.741 −54.941 −10.599 1.00 15.33 C ATOM 962 CB SER A 368 −45.691 −54.568 −9.461 1.00 12.80 C ATOM 963 OG SER A 368 −45.979 −55.712 −8.613 1.00 14.96 O ATOM 964 C SER A 368 −43.394 −55.294 −10.028 1.00 17.57 C ATOM 965 O SER A 368 −43.087 −56.509 −9.751 1.00 12.24 O ATOM 966 N ASN A 369 −42.594 −54.273 −9.752 1.00 14.28 N ATOM 967 CA ASN A 369 −41.326 −54.509 −9.008 1.00 16.30 C ATOM 968 CB ASN A 369 −41.594 −55.094 −7.607 1.00 14.64 C ATOM 969 CG ASN A 369 −42.520 −54.205 −6.756 1.00 22.27 C ATOM 970 OD1 ASN A 369 −43.479 −54.686 −6.138 1.00 22.99 O ATOM 971 ND2 ASN A 369 −42.233 −52.924 −6.719 1.00 21.01 N ATOM 972 C ASN A 369 −40.286 −55.358 −9.735 1.00 18.98 C ATOM 973 O ASN A 369 −39.487 −56.083 −9.110 1.00 14.50 O ATOM 974 N LEU A 370 −40.273 −55.239 −11.051 1.00 16.99 N ATOM 975 CA LEU A 370 −39.294 −55.949 −11.869 1.00 12.55 C ATOM 976 CB LEU A 370 −40.006 −56.834 −12.901 1.00 10.81 C ATOM 977 CG LEU A 370 −40.747 −58.106 −12.387 1.00 12.87 C ATOM 978 CD1 LEU A 370 −41.670 −58.681 −13.421 1.00 12.43 C ATOM 979 CD2 LEU A 370 −39.766 −59.207 −11.944 1.00 12.43 C ATOM 980 C LEU A 370 −38.423 −54.956 −12.610 1.00 16.72 C ATOM 981 O LEU A 370 −38.922 −53.905 −13.052 1.00 17.43 O ATOM 982 N ASN A 371 −37.139 −55.304 −12.766 1.00 14.26 N ATOM 983 CA ASN A 371 −36.161 −54.592 −13.622 1.00 18.25 C ATOM 984 CB ASN A 371 −34.777 −54.482 −12.909 1.00 20.24 C ATOM 985 CG ASN A 371 −34.777 −53.504 −11.774 1.00 24.61 C ATOM 986 OD1 ASN A 371 −35.582 −52.586 −11.736 1.00 27.12 O ATOM 987 ND2 ASN A 371 −33.886 −53.711 −10.825 1.00 22.97 N ATOM 988 C ASN A 371 −35.906 −55.405 −14.879 1.00 17.19 C ATOM 989 O ASN A 371 −35.697 −56.616 −14.815 1.00 20.36 O ATOM 990 N LEU A 372 −35.844 −54.703 −16.003 1.00 19.89 N ATOM 991 CA LEU A 372 −35.594 −55.278 −17.302 1.00 22.70 C ATOM 992 CB LEU A 372 −36.326 −54.454 −18.371 1.00 23.01 C ATOM 993 CG LEU A 372 −37.851 −54.502 −18.211 1.00 28.06 C ATOM 994 CD1 LEU A 372 −38.586 −53.484 −19.101 1.00 23.53 C ATOM 995 CD2 LEU A 372 −38.309 −55.944 −18.422 1.00 23.50 C ATOM 996 C LEU A 372 −34.110 −55.228 −17.531 1.00 24.23 C ATOM 997 O LEU A 372 −33.490 −54.191 −17.322 1.00 23.34 O ATOM 998 N ILE A 373 −33.536 −56.368 −17.912 1.00 23.65 N ATOM 999 CA ILE A 373 −32.117 −56.473 −18.189 1.00 25.47 C ATOM 1000 CB ILE A 373 −31.475 −57.717 −17.493 1.00 25.23 C ATOM 1001 CG1 ILE A 373 −31.792 −57.742 −15.991 1.00 27.87 C ATOM 1002 CD1 ILE A 373 −31.115 −56.644 −15.192 1.00 30.17 C ATOM 1003 CG2 ILE A 373 −29.964 −57.798 −17.774 1.00 20.63 C ATOM 1004 C ILE A 373 −31.927 −56.631 −19.694 1.00 30.64 C ATOM 1005 O ILE A 373 −32.381 −57.622 −20.281 1.00 25.80 O ATOM 1006 N GLY A 374 −31.241 −55.667 −20.310 1.00 40.08 N ATOM 1007 CA GLY A 374 −30.862 −55.750 −21.727 1.00 29.77 C ATOM 1008 C GLY A 374 −31.978 −55.364 −22.671 1.00 33.77 C ATOM 1009 O GLY A 374 −32.931 −54.638 −22.288 1.00 30.25 O ATOM 1010 N ARG A 375 −31.869 −55.871 −23.904 1.00 31.87 N ATOM 1011 CA ARG A 375 −32.721 −55.456 −25.024 1.00 35.43 C ATOM 1012 CB ARG A 375 −31.873 −54.887 −26.186 1.00 40.72 C ATOM 1013 CG ARG A 375 −30.503 −54.349 −25.778 1.00 49.60 C ATOM 1014 CD ARG A 375 −29.985 −53.249 −26.710 1.00 56.13 C ATOM 1015 NE ARG A 375 −30.302 −53.452 −28.130 1.00 56.53 N ATOM 1016 CZ ARG A 375 −29.766 −54.398 −28.908 1.00 66.94 C ATOM 1017 NH1 ARG A 375 −28.890 −55.272 −28.412 1.00 57.97 N ATOM 1018 NH2 ARG A 375 −30.125 −54.484 −30.186 1.00 65.01 N ATOM 1019 C ARG A 375 −33.524 −56.651 −25.509 1.00 22.72 C ATOM 1020 O ARG A 375 −33.083 −57.789 −25.381 1.00 23.47 O ATOM 1021 N PRO A 376 −34.712 −56.404 −26.055 1.00 27.17 N ATOM 1022 CA PRO A 376 −35.521 −57.566 −26.460 1.00 23.38 C ATOM 1023 CB PRO A 376 −36.763 −56.924 −27.084 1.00 26.07 C ATOM 1024 CG PRO A 376 −36.740 −55.460 −26.661 1.00 25.82 C ATOM 1025 CD PRO A 376 −35.290 −55.127 −26.523 1.00 24.80 C ATOM 1026 C PRO A 376 −34.791 −58.473 −27.499 1.00 26.42 C ATOM 1027 O PRO A 376 −34.043 −57.976 −28.335 1.00 23.49 O ATOM 1028 N SER A 377 −35.023 −59.781 −27.440 1.00 20.17 N ATOM 1029 CA SER A 377 −34.551 −60.701 −28.500 1.00 16.85 C ATOM 1030 CB SER A 377 −33.404 −61.574 −27.980 1.00 16.67 C ATOM 1031 OG SER A 377 −33.128 −62.581 −28.919 1.00 19.77 O ATOM 1032 C SER A 377 −35.707 −61.620 −28.924 1.00 19.59 C ATOM 1033 O SER A 377 −36.581 −61.943 −28.110 1.00 18.18 O ATOM 1034 N THR A 378 −35.698 −62.072 −30.167 1.00 15.70 N ATOM 1035 CA THR A 378 −36.683 −63.049 −30.614 1.00 15.97 C ATOM 1036 CB THR A 378 −37.269 −62.661 −31.965 1.00 14.40 C ATOM 1037 OG1 THR A 378 −36.208 −62.595 −32.909 1.00 13.75 O ATOM 1038 CG2 THR A 378 −37.942 −61.270 −31.897 1.00 12.82 C ATOM 1039 C THR A 378 −36.053 −64.472 −30.708 1.00 14.84 C ATOM 1040 O THR A 378 −36.718 −65.416 −31.076 1.00 15.16 O ATOM 1041 N VAL A 379 −34.799 −64.618 −30.305 1.00 18.35 N ATOM 1042 CA VAL A 379 −34.134 −65.921 −30.365 1.00 18.94 C ATOM 1043 CB VAL A 379 −32.648 −65.844 −29.923 1.00 24.44 C ATOM 1044 CG1 VAL A 379 −31.998 −67.211 −30.040 1.00 24.06 C ATOM 1045 CG2 VAL A 379 −31.874 −64.822 −30.753 1.00 26.63 C ATOM 1046 C VAL A 379 −34.871 −66.938 −29.470 1.00 16.61 C ATOM 1047 O VAL A 379 −35.082 −66.681 −28.274 1.00 13.91 O ATOM 1048 N HIS A 380 −35.278 −68.062 −30.067 1.00 12.50 N ATOM 1049 CA HIS A 380 −35.976 −69.131 −29.354 1.00 16.25 C ATOM 1050 CB HIS A 380 −35.040 −69.790 −28.313 1.00 16.87 C ATOM 1051 CG HIS A 380 −33.830 −70.429 −28.923 1.00 16.97 C ATOM 1052 ND1 HIS A 380 −33.915 −71.281 −29.960 1.00 18.68 N ATOM 1053 CE1 HIS A 380 −32.664 −71.662 −30.319 1.00 15.19 C ATOM 1054 NE2 HIS A 380 −31.796 −71.063 −29.497 1.00 13.72 N ATOM 1055 CD2 HIS A 380 −32.472 −70.288 −28.632 1.00 15.25 C ATOM 1056 C HIS A 380 −37.230 −68.686 −28.654 1.00 14.99 C ATOM 1057 O HIS A 380 −37.635 −69.304 −27.656 1.00 14.35 O ATOM 1058 N SER A 381 −37.879 −67.626 −29.147 1.00 17.91 N ATOM 1059 CA SER A 381 −39.014 −67.082 −28.390 1.00 16.58 C ATOM 1060 CB SER A 381 −39.629 −65.870 −29.088 1.00 15.40 C ATOM 1061 OG SER A 381 −40.754 −65.415 −28.287 1.00 15.19 O ATOM 1062 C SER A 381 −40.105 −68.158 −28.237 1.00 19.84 C ATOM 1063 O SER A 381 −40.519 −68.779 −29.231 1.00 18.86 O ATOM 1064 N TRP A 382 −40.582 −68.372 −27.014 1.00 14.81 N ATOM 1065 CA TRP A 382 −41.701 −69.323 −26.781 1.00 15.49 C ATOM 1066 CB TRP A 382 −41.851 −69.648 −25.293 1.00 14.77 C ATOM 1067 CG TRP A 382 −40.588 −70.187 −24.692 1.00 14.91 C ATOM 1068 CD1 TRP A 382 −39.669 −71.066 −25.293 1.00 18.26 C ATOM 1069 NE1 TRP A 382 −38.594 −71.319 −24.439 1.00 12.13 N ATOM 1070 CE2 TRP A 382 −38.762 −70.665 −23.270 1.00 17.46 C ATOM 1071 CD2 TRP A 382 −40.036 −69.915 −23.358 1.00 14.44 C ATOM 1072 CE3 TRP A 382 −40.423 −69.134 −22.288 1.00 14.70 C ATOM 1073 CZ3 TRP A 382 −39.606 −69.119 −21.135 1.00 13.89 C ATOM 1074 CH2 TRP A 382 −38.414 −69.852 −21.063 1.00 20.20 C ATOM 1075 CZ2 TRP A 382 −37.976 −70.649 −22.131 1.00 19.45 C ATOM 1076 C TRP A 382 −42.999 −68.836 −27.308 1.00 18.88 C ATOM 1077 O TRP A 382 −43.952 −69.597 −27.394 1.00 18.02 O ATOM 1078 N PHE A 383 −43.070 −67.553 −27.663 1.00 16.56 N ATOM 1079 CA PHE A 383 −44.327 −66.979 −28.167 1.00 19.34 C ATOM 1080 CB PHE A 383 −44.910 −65.992 −27.108 1.00 17.83 C ATOM 1081 CG PHE A 383 −45.151 −66.647 −25.789 1.00 18.66 C ATOM 1082 CD1 PHE A 383 −46.258 −67.476 −25.602 1.00 20.02 C ATOM 1083 CE1 PHE A 383 −46.478 −68.076 −24.364 1.00 20.48 C ATOM 1084 CZ PHE A 383 −45.582 −67.883 −23.330 1.00 17.66 C ATOM 1085 CE2 PHE A 383 −44.471 −67.081 −23.520 1.00 19.65 C ATOM 1086 CD2 PHE A 383 −44.261 −66.464 −24.729 1.00 16.13 C ATOM 1087 C PHE A 383 −44.127 −66.331 −29.521 1.00 18.27 C ATOM 1088 O PHE A 383 −43.732 −65.158 −29.603 1.00 16.82 O ATOM 1089 N PRO A 384 −44.372 −67.091 −30.607 1.00 18.52 N ATOM 1090 CA PRO A 384 −44.084 −66.500 −31.928 1.00 19.97 C ATOM 1091 CB PRO A 384 −44.671 −67.532 −32.916 1.00 24.72 C ATOM 1092 CG PRO A 384 −44.550 −68.839 −32.179 1.00 26.06 C ATOM 1093 CD PRO A 384 −44.801 −68.505 −30.712 1.00 23.38 C ATOM 1094 C PRO A 384 −44.703 −65.138 −32.118 1.00 19.26 C ATOM 1095 O PRO A 384 −45.880 −64.904 −31.764 1.00 21.43 O ATOM 1096 N GLY A 385 −43.915 −64.199 −32.611 1.00 17.34 N ATOM 1097 CA GLY A 385 −44.446 −62.856 −32.775 1.00 16.74 C ATOM 1098 C GLY A 385 −44.047 −61.926 −31.651 1.00 17.50 C ATOM 1099 O GLY A 385 −44.235 −60.711 −31.760 1.00 20.19 O ATOM 1100 N TYR A 386 −43.470 −62.468 −30.582 1.00 14.44 N ATOM 1101 CA TYR A 386 −43.026 −61.630 −29.453 1.00 17.66 C ATOM 1102 CB TYR A 386 −43.762 −62.008 −28.135 1.00 14.77 C ATOM 1103 CG TYR A 386 −45.239 −61.680 −28.080 1.00 13.34 C ATOM 1104 CD1 TYR A 386 −45.678 −60.448 −27.549 1.00 16.21 C ATOM 1105 CE1 TYR A 386 −47.035 −60.132 −27.482 1.00 14.94 C ATOM 1106 CZ TYR A 386 −47.966 −61.076 −27.932 1.00 12.65 C ATOM 1107 OH TYR A 386 −49.285 −60.725 −27.892 1.00 17.80 O ATOM 1108 CE2 TYR A 386 −47.569 −62.287 −28.491 1.00 15.41 C ATOM 1109 CD2 TYR A 386 −46.207 −62.614 −28.517 1.00 14.24 C ATOM 1110 C TYR A 386 −41.520 −61.776 −29.219 1.00 17.85 C ATOM 1111 O TYR A 386 −40.938 −62.851 −29.484 1.00 13.88 O ATOM 1112 N ALA A 387 −40.911 −60.716 −28.692 1.00 14.42 N ATOM 1113 CA ALA A 387 −39.511 −60.732 −28.316 1.00 15.38 C ATOM 1114 CB ALA A 387 −38.811 −59.468 −28.835 1.00 16.52 C ATOM 1115 C ALA A 387 −39.497 −60.766 −26.774 1.00 16.71 C ATOM 1116 O ALA A 387 −40.475 −60.395 −26.152 1.00 17.57 O ATOM 1117 N TRP A 388 −38.401 −61.225 −26.165 1.00 18.28 N ATOM 1118 CA TRP A 388 −38.337 −61.362 −24.689 1.00 17.97 C ATOM 1119 CB TRP A 388 −38.132 −62.833 −24.265 1.00 15.76 C ATOM 1120 CG TRP A 388 −36.982 −63.504 −24.964 1.00 15.78 C ATOM 1121 CD1 TRP A 388 −37.037 −64.300 −26.119 1.00 14.89 C ATOM 1122 NE1 TRP A 388 −35.756 −64.772 −26.447 1.00 15.14 N ATOM 1123 CE2 TRP A 388 −34.844 −64.310 −25.558 1.00 15.16 C ATOM 1124 CD2 TRP A 388 −35.572 −63.497 −24.563 1.00 14.26 C ATOM 1125 CE3 TRP A 388 −34.855 −62.911 −23.521 1.00 19.41 C ATOM 1126 CZ3 TRP A 388 −33.461 −63.131 −23.444 1.00 17.01 C ATOM 1127 CH2 TRP A 388 −32.786 −63.917 −24.404 1.00 17.22 C ATOM 1128 CZ2 TRP A 388 −33.464 −64.509 −25.483 1.00 18.47 C ATOM 1129 C TRP A 388 −37.236 −60.505 −24.145 1.00 18.56 C ATOM 1130 O TRP A 388 −36.283 −60.232 −24.835 1.00 21.53 O ATOM 1131 N THR A 389 −37.418 −60.005 −22.922 1.00 19.67 N ATOM 1132 CA THR A 389 −36.392 −59.249 −22.210 1.00 17.49 C ATOM 1133 CB THR A 389 −36.783 −57.783 −22.113 1.00 17.05 C ATOM 1134 OG1 THR A 389 −37.002 −57.255 −23.435 1.00 22.08 O ATOM 1135 CG2 THR A 389 −35.727 −56.992 −21.409 1.00 20.15 C ATOM 1136 C THR A 389 −36.389 −59.844 −20.802 1.00 19.83 C ATOM 1137 O THR A 389 −37.456 −60.041 −20.208 1.00 18.79 O ATOM 1138 N ILE A 390 −35.208 −60.205 −20.298 1.00 19.22 N ATOM 1139 CA ILE A 390 −35.083 −60.760 −18.962 1.00 17.37 C ATOM 1140 CB ILE A 390 −33.593 −61.143 −18.664 1.00 19.28 C ATOM 1141 CG1 ILE A 390 −33.228 −62.410 −19.480 1.00 18.85 C ATOM 1142 CD1 ILE A 390 −31.828 −62.958 −19.263 1.00 23.45 C ATOM 1143 CG2 ILE A 390 −33.354 −61.349 −17.174 1.00 14.98 C ATOM 1144 C ILE A 390 −35.650 −59.790 −17.945 1.00 13.73 C ATOM 1145 O ILE A 390 −35.416 −58.597 −18.031 1.00 14.66 O ATOM 1146 N ALA A 391 −36.414 −60.321 −16.997 1.00 15.70 N ATOM 1147 CA ALA A 391 −37.033 −59.535 −15.917 1.00 18.19 C ATOM 1148 CB ALA A 391 −38.555 −59.566 −16.009 1.00 15.92 C ATOM 1149 C ALA A 391 −36.629 −60.101 −14.575 1.00 17.96 C ATOM 1150 O ALA A 391 −36.987 −61.248 −14.243 1.00 15.71 O ATOM 1151 N GLN A 392 −36.005 −59.260 −13.758 1.00 14.21 N ATOM 1152 CA GLN A 392 −35.609 −59.713 −12.440 1.00 16.77 C ATOM 1153 CB GLN A 392 −34.078 −59.727 −12.343 1.00 19.87 C ATOM 1154 CG GLN A 392 −33.447 −58.344 −12.426 1.00 19.94 C ATOM 1155 CD GLN A 392 −31.910 −58.414 −12.400 1.00 26.36 C ATOM 1156 OE1 GLN A 392 −31.299 −59.308 −12.998 1.00 19.49 O ATOM 1157 NE2 GLN A 392 −31.297 −57.483 −11.705 1.00 24.80 N ATOM 1158 C GLN A 392 −36.235 −58.883 −11.316 1.00 16.98 C ATOM 1159 O GLN A 392 −36.581 −57.674 −11.499 1.00 16.93 O ATOM 1160 N CYS A 393 −36.411 −59.508 −10.158 1.00 13.99 N ATOM 1161 CA CYS A 393 −37.019 −58.802 −9.012 1.00 14.50 C ATOM 1162 CB CYS A 393 −37.076 −59.758 −7.808 1.00 13.21 C ATOM 1163 SG CYS A 393 −37.495 −58.995 −6.243 1.00 12.92 S ATOM 1164 C CYS A 393 −36.135 −57.580 −8.690 1.00 15.38 C ATOM 1165 O CYS A 393 −34.908 −57.687 −8.625 1.00 16.45 O ATOM 1166 N LYS A 394 −36.748 −56.411 −8.504 1.00 15.64 N ATOM 1167 CA LYS A 394 −35.959 −55.216 −8.263 1.00 19.52 C ATOM 1168 CB LYS A 394 −36.811 −53.942 −8.432 1.00 20.04 C ATOM 1169 CG LYS A 394 −37.774 −53.659 −7.306 1.00 29.57 C ATOM 1170 CD LYS A 394 −38.365 −52.237 −7.449 1.00 41.91 C ATOM 1171 CE LYS A 394 −38.830 −51.660 −6.107 1.00 45.12 C ATOM 1172 NZ LYS A 394 −40.309 −51.715 −5.894 1.00 38.32 N ATOM 1173 C LYS A 394 −35.304 −55.244 −6.856 1.00 17.29 C ATOM 1174 O LYS A 394 −34.442 −54.420 −6.569 1.00 14.97 O ATOM 1175 N ILE A 395 −35.765 −56.150 −5.980 1.00 13.67 N ATOM 1176 CA ILE A 395 −35.288 −56.175 −4.602 1.00 14.65 C ATOM 1177 CB ILE A 395 −36.443 −56.463 −3.602 1.00 14.46 C ATOM 1178 CG1 ILE A 395 −37.460 −55.282 −3.603 1.00 14.67 C ATOM 1179 CD1 ILE A 395 −36.916 −54.025 −2.915 1.00 23.87 C ATOM 1180 CG2 ILE A 395 −35.887 −56.718 −2.183 1.00 19.10 C ATOM 1181 C ILE A 395 −34.111 −57.137 −4.409 1.00 19.30 C ATOM 1182 O ILE A 395 −33.122 −56.774 −3.760 1.00 20.69 O ATOM 1183 N CYS A 396 −34.198 −58.343 −4.987 1.00 14.04 N ATOM 1184 CA CYS A 396 −33.184 −59.342 −4.762 1.00 13.83 C ATOM 1185 CB CYS A 396 −33.764 −60.481 −3.933 1.00 14.67 C ATOM 1186 SG CYS A 396 −34.794 −61.550 −4.945 1.00 14.64 S ATOM 1187 C CYS A 396 −32.530 −59.830 −6.058 1.00 14.71 C ATOM 1188 O CYS A 396 −31.572 −60.584 −6.018 1.00 15.61 O ATOM 1189 N ALA A 397 −33.024 −59.336 −7.196 1.00 13.70 N ATOM 1190 CA ALA A 397 −32.498 −59.667 −8.532 1.00 12.82 C ATOM 1191 CB ALA A 397 −31.031 −59.243 −8.692 1.00 15.74 C ATOM 1192 C ALA A 397 −32.715 −61.136 −8.965 1.00 13.16 C ATOM 1193 O ALA A 397 −32.079 −61.614 −9.929 1.00 13.19 O ATOM 1194 N SER A 398 −33.594 −61.842 −8.271 1.00 12.64 N ATOM 1195 CA SER A 398 −33.997 −63.185 −8.715 1.00 16.04 C ATOM 1196 CB SER A 398 −35.083 −63.743 −7.758 1.00 17.35 C ATOM 1197 OG SER A 398 −35.610 −64.966 −8.243 1.00 18.64 O ATOM 1198 C SER A 398 −34.555 −63.098 −10.161 1.00 17.37 C ATOM 1199 O SER A 398 −35.362 −62.204 −10.479 1.00 13.68 O ATOM 1200 N HIS A 399 −34.158 −64.024 −11.033 1.00 18.11 N ATOM 1201 CA HIS A 399 −34.697 −64.049 −12.405 1.00 25.35 C ATOM 1202 CB HIS A 399 −33.760 −64.829 −13.353 1.00 32.41 C ATOM 1203 CG HIS A 399 −32.486 −64.075 −13.718 1.00 40.12 C ATOM 1204 ND1 HIS A 399 −31.730 −63.421 −12.799 1.00 49.50 N ATOM 1205 CE1 HIS A 399 −30.681 −62.830 −13.418 1.00 57.52 C ATOM 1206 NE2 HIS A 399 −30.762 −63.103 −14.734 1.00 51.93 N ATOM 1207 CD2 HIS A 399 −31.856 −63.875 −14.954 1.00 46.42 C ATOM 1208 C HIS A 399 −36.095 −64.630 −12.367 1.00 21.09 C ATOM 1209 O HIS A 399 −36.264 −65.808 −12.223 1.00 21.71 O ATOM 1210 N ILE A 400 −37.120 −63.793 −12.470 1.00 18.37 N ATOM 1211 CA ILE A 400 −38.482 −64.281 −12.251 1.00 16.01 C ATOM 1212 CB ILE A 400 −39.415 −63.176 −11.680 1.00 17.40 C ATOM 1213 CG1 ILE A 400 −38.760 −62.526 −10.474 1.00 18.29 C ATOM 1214 CD1 ILE A 400 −38.686 −63.436 −9.288 1.00 18.42 C ATOM 1215 CG2 ILE A 400 −40.862 −63.726 −11.418 1.00 11.98 C ATOM 1216 C ILE A 400 −39.066 −64.762 −13.589 1.00 17.64 C ATOM 1217 O ILE A 400 −39.883 −65.705 −13.599 1.00 14.38 O ATOM 1218 N GLY A 401 −38.680 −64.078 −14.681 1.00 13.14 N ATOM 1219 CA GLY A 401 −39.159 −64.407 −16.055 1.00 12.65 C ATOM 1220 C GLY A 401 −38.731 −63.382 −17.091 1.00 14.46 C ATOM 1221 O GLY A 401 −37.570 −62.915 −17.107 1.00 14.36 O ATOM 1222 N TRP A 402 −39.669 −63.021 −17.964 1.00 12.19 N ATOM 1223 CA TRP A 402 −39.391 −62.188 −19.134 1.00 18.04 C ATOM 1224 CB TRP A 402 −39.149 −63.081 −20.384 1.00 14.45 C ATOM 1225 CG TRP A 402 −38.043 −64.080 −20.144 1.00 14.71 C ATOM 1226 CD1 TRP A 402 −36.705 −63.937 −20.460 1.00 16.61 C ATOM 1227 NE1 TRP A 402 −35.991 −65.033 −20.047 1.00 15.86 N ATOM 1228 CE2 TRP A 402 −36.802 −65.933 −19.444 1.00 16.72 C ATOM 1229 CD2 TRP A 402 −38.144 −65.387 −19.478 1.00 16.48 C ATOM 1230 CE3 TRP A 402 −39.195 −66.127 −18.910 1.00 18.92 C ATOM 1231 CZ3 TRP A 402 −38.899 −67.370 −18.330 1.00 19.68 C ATOM 1232 CH2 TRP A 402 −37.589 −67.886 −18.324 1.00 20.14 C ATOM 1233 CZ2 TRP A 402 −36.519 −67.177 −18.882 1.00 20.08 C ATOM 1234 C TRP A 402 −40.562 −61.283 −19.403 1.00 14.88 C ATOM 1235 O TRP A 402 −41.718 −61.644 −19.136 1.00 17.92 O ATOM 1236 N LYS A 403 −40.266 −60.095 −19.904 1.00 14.10 N ATOM 1237 CA LYS A 403 −41.273 −59.239 −20.523 1.00 16.30 C ATOM 1238 CB LYS A 403 −40.853 −57.786 −20.400 1.00 17.15 C ATOM 1239 CG LYS A 403 −41.971 −56.782 −20.679 1.00 18.91 C ATOM 1240 CD LYS A 403 −41.451 −55.357 −20.842 1.00 25.96 C ATOM 1241 CE LYS A 403 −42.623 −54.372 −20.750 1.00 30.89 C ATOM 1242 NZ LYS A 403 −42.109 −52.984 −20.720 1.00 28.14 N ATOM 1243 C LYS A 403 −41.318 −59.646 −21.999 1.00 16.99 C ATOM 1244 O LYS A 403 −40.270 −59.725 −22.637 1.00 17.42 O ATOM 1245 N PHE A 404 −42.515 −59.932 −22.516 1.00 14.00 N ATOM 1246 CA PHE A 404 −42.711 −60.267 −23.910 1.00 13.50 C ATOM 1247 CB PHE A 404 −43.584 −61.535 −24.087 1.00 13.33 C ATOM 1248 CG PHE A 404 −42.843 −62.812 −23.809 1.00 12.31 C ATOM 1249 CD1 PHE A 404 −42.048 −63.415 −24.810 1.00 14.09 C ATOM 1250 CE1 PHE A 404 −41.308 −64.598 −24.524 1.00 16.37 C ATOM 1251 CZ PHE A 404 −41.342 −65.165 −23.239 1.00 15.21 C ATOM 1252 CE2 PHE A 404 −42.092 −64.554 −22.223 1.00 12.03 C ATOM 1253 CD2 PHE A 404 −42.842 −63.383 −22.498 1.00 12.03 C ATOM 1254 C PHE A 404 −43.332 −59.082 −24.623 1.00 16.14 C ATOM 1255 O PHE A 404 −44.305 −58.534 −24.150 1.00 16.05 O ATOM 1256 N THR A 405 −42.707 −58.640 −25.715 1.00 15.96 N ATOM 1257 CA THR A 405 −43.198 −57.466 −26.454 1.00 16.34 C ATOM 1258 CB THR A 405 −42.172 −56.330 −26.432 1.00 19.77 C ATOM 1259 OG1 THR A 405 −40.869 −56.883 −26.644 1.00 22.44 O ATOM 1260 CG2 THR A 405 −42.181 −55.642 −25.059 1.00 24.07 C ATOM 1261 C THR A 405 −43.479 −57.867 −27.910 1.00 19.59 C ATOM 1262 O THR A 405 −42.666 −58.542 −28.546 1.00 18.75 O ATOM 1263 N ALA A 406 −44.646 −57.470 −28.411 1.00 17.50 N ATOM 1264 CA ALA A 406 −45.119 −57.836 −29.734 1.00 17.88 C ATOM 1265 CB ALA A 406 −46.565 −57.353 −29.919 1.00 15.89 C ATOM 1266 C ALA A 406 −44.229 −57.181 −30.784 1.00 19.22 C ATOM 1267 O ALA A 406 −43.913 −56.035 −30.644 1.00 16.64 O ATOM 1268 N THR A 407 −43.816 −57.924 −31.821 1.00 18.73 N ATOM 1269 CA THR A 407 −43.056 −57.321 −32.919 1.00 18.40 C ATOM 1270 CB THR A 407 −42.168 −58.351 −33.638 1.00 22.40 C ATOM 1271 OG1 THR A 407 −42.999 −59.417 −34.108 1.00 22.23 O ATOM 1272 CG2 THR A 407 −41.142 −58.893 −32.723 1.00 17.33 C ATOM 1273 C THR A 407 −43.937 −56.634 −33.984 1.00 25.13 C ATOM 1274 O THR A 407 −43.425 −55.847 −34.781 1.00 27.79 O ATOM 1275 N LYS A 408 −45.237 −56.956 −34.027 1.00 23.64 N ATOM 1276 CA LYS A 408 −46.195 −56.289 −34.937 1.00 27.76 C ATOM 1277 CB LYS A 408 −46.800 −57.289 −35.941 1.00 32.50 C ATOM 1278 CG LYS A 408 −45.810 −57.843 −36.965 1.00 39.28 C ATOM 1279 CD LYS A 408 −46.185 −59.248 −37.414 1.00 52.03 C ATOM 1280 CE LYS A 408 −46.850 −59.275 −38.784 1.00 49.43 C ATOM 1281 NZ LYS A 408 −48.242 −58.743 −38.745 1.00 53.48 N ATOM 1282 C LYS A 408 −47.322 −55.557 −34.183 1.00 28.58 C ATOM 1283 O LYS A 408 −47.872 −56.063 −33.179 1.00 20.88 O ATOM 1284 N LYS A 409 −47.708 −54.397 −34.708 1.00 21.40 N ATOM 1285 CA LYS A 409 −48.651 −53.535 −34.028 1.00 24.82 C ATOM 1286 CB LYS A 409 −48.628 −52.139 −34.646 1.00 29.84 C ATOM 1287 CG LYS A 409 −47.344 −51.364 −34.352 1.00 46.09 C ATOM 1288 CD LYS A 409 −47.648 −49.919 −33.965 1.00 48.46 C ATOM 1289 CE LYS A 409 −46.821 −48.926 −34.776 1.00 62.40 C ATOM 1290 NZ LYS A 409 −45.356 −49.065 −34.529 1.00 68.67 N ATOM 1291 C LYS A 409 −50.083 −54.085 −34.001 1.00 20.47 C ATOM 1292 O LYS A 409 −50.878 −53.670 −33.175 1.00 22.28 O ATOM 1293 N ASP A 410 −50.408 −55.024 −34.883 1.00 19.43 N ATOM 1294 CA ASP A 410 −51.781 −55.566 −34.924 1.00 25.03 C ATOM 1295 CB ASP A 410 −52.167 −56.011 −36.349 1.00 27.05 C ATOM 1296 CG ASP A 410 −51.265 −57.127 −36.894 1.00 37.79 C ATOM 1297 OD1 ASP A 410 −50.301 −57.535 −36.218 1.00 53.46 O ATOM 1298 OD2 ASP A 410 −51.524 −57.607 −38.006 1.00 42.24 O ATOM 1299 C ASP A 410 −52.043 −56.700 −33.917 1.00 21.12 C ATOM 1300 O ASP A 410 −53.138 −57.263 −33.873 1.00 25.62 O ATOM 1301 N MET A 411 −51.034 −57.055 −33.127 1.00 21.32 N ATOM 1302 CA MET A 411 −51.183 −58.116 −32.116 1.00 23.21 C ATOM 1303 CB MET A 411 −49.822 −58.747 −31.851 1.00 18.74 C ATOM 1304 CG MET A 411 −49.227 −59.295 −33.124 1.00 23.21 C ATOM 1305 SD MET A 411 −47.764 −60.215 −32.684 1.00 27.39 S ATOM 1306 CE MET A 411 −46.446 −59.149 −33.164 1.00 23.85 C ATOM 1307 C MET A 411 −51.784 −57.607 −30.794 1.00 19.87 C ATOM 1308 O MET A 411 −51.713 −56.403 −30.486 1.00 20.22 O ATOM 1309 N SER A 412 −52.405 −58.502 −30.024 1.00 16.83 N ATOM 1310 CA SER A 412 −52.854 −58.127 −28.666 1.00 19.04 C ATOM 1311 CB SER A 412 −54.354 −57.793 −28.612 1.00 19.35 C ATOM 1312 OG SER A 412 −55.128 −58.890 −29.067 1.00 19.95 O ATOM 1313 C SER A 412 −52.459 −59.266 −27.731 1.00 16.67 C ATOM 1314 O SER A 412 −52.666 −60.437 −28.130 1.00 17.24 O ATOM 1315 N PRO A 413 −52.336 −58.953 −26.424 1.00 13.18 N ATOM 1316 CA PRO A 413 −51.617 −57.729 −25.960 1.00 15.23 C ATOM 1317 CB PRO A 413 −51.320 −58.032 −24.481 1.00 14.93 C ATOM 1318 CG PRO A 413 −51.089 −59.522 −24.453 1.00 13.07 C ATOM 1319 CD PRO A 413 −51.910 −60.138 −25.605 1.00 11.36 C ATOM 1320 C PRO A 413 −50.349 −57.333 −26.702 1.00 14.82 C ATOM 1321 O PRO A 413 −49.639 −58.188 −27.174 1.00 16.68 O ATOM 1322 N GLN A 414 −50.052 −56.032 −26.746 1.00 13.59 N ATOM 1323 CA GLN A 414 −48.750 −55.555 −27.217 1.00 17.30 C ATOM 1324 CB GLN A 414 −48.769 −54.031 −27.440 1.00 20.46 C ATOM 1325 CG GLN A 414 −49.522 −53.599 −28.720 1.00 15.19 C ATOM 1326 CD GLN A 414 −48.791 −54.074 −29.979 1.00 17.58 C ATOM 1327 OE1 GLN A 414 −49.239 −54.981 −30.703 1.00 20.26 O ATOM 1328 NE2 GLN A 414 −47.647 −53.508 −30.202 1.00 16.26 N ATOM 1329 C GLN A 414 −47.576 −55.972 −26.311 1.00 16.74 C ATOM 1330 O GLN A 414 −46.423 −56.091 −26.764 1.00 18.40 O ATOM 1331 N LYS A 415 −47.859 −56.197 −25.027 1.00 18.31 N ATOM 1332 CA LYS A 415 −46.860 −56.743 −24.130 1.00 18.39 C ATOM 1333 CB LYS A 415 −45.905 −55.635 −23.559 1.00 22.73 C ATOM 1334 CG LYS A 415 −46.502 −54.706 −22.523 1.00 19.40 C ATOM 1335 CD LYS A 415 −46.352 −55.249 −21.077 1.00 26.70 C ATOM 1336 CE LYS A 415 −47.327 −54.495 −20.148 1.00 22.76 C ATOM 1337 NZ LYS A 415 −47.747 −53.243 −20.781 1.00 23.26 N ATOM 1338 C LYS A 415 −47.537 −57.573 −23.034 1.00 13.21 C ATOM 1339 O LYS A 415 −48.729 −57.408 −22.755 1.00 10.23 O ATOM 1340 N PHE A 416 −46.799 −58.523 −22.505 1.00 11.61 N ATOM 1341 CA PHE A 416 −47.244 −59.267 −21.333 1.00 12.74 C ATOM 1342 CB PHE A 416 −48.214 −60.453 −21.671 1.00 12.29 C ATOM 1343 CG PHE A 416 −47.590 −61.535 −22.534 1.00 14.03 C ATOM 1344 CD1 PHE A 416 −47.044 −62.683 −21.963 1.00 11.00 C ATOM 1345 CE1 PHE A 416 −46.453 −63.677 −22.750 1.00 13.79 C ATOM 1346 CZ PHE A 416 −46.358 −63.526 −24.128 1.00 16.73 C ATOM 1347 CE2 PHE A 416 −46.881 −62.388 −24.729 1.00 15.15 C ATOM 1348 CD2 PHE A 416 −47.506 −61.379 −23.930 1.00 14.19 C ATOM 1349 C PHE A 416 −45.969 −59.755 −20.607 1.00 14.10 C ATOM 1350 O PHE A 416 −44.851 −59.455 −21.025 1.00 14.39 O ATOM 1351 N TRP A 417 −46.166 −60.372 −19.450 1.00 14.54 N ATOM 1352 CA TRP A 417 −45.080 −60.976 −18.707 1.00 14.28 C ATOM 1353 CB TRP A 417 −45.028 −60.431 −17.261 1.00 14.42 C ATOM 1354 CG TRP A 417 −44.951 −58.914 −17.226 1.00 13.79 C ATOM 1355 CD1 TRP A 417 −46.012 −58.004 −17.351 1.00 16.30 C ATOM 1356 NE1 TRP A 417 −45.540 −56.709 −17.289 1.00 14.75 N ATOM 1357 CE2 TRP A 417 −44.203 −56.697 −17.104 1.00 15.15 C ATOM 1358 CD2 TRP A 417 −43.755 −58.088 −17.052 1.00 11.55 C ATOM 1359 CE3 TRP A 417 −42.394 −58.358 −16.945 1.00 11.45 C ATOM 1360 CZ3 TRP A 417 −41.513 −57.306 −16.826 1.00 15.81 C ATOM 1361 CH2 TRP A 417 −41.966 −55.946 −16.837 1.00 14.85 C ATOM 1362 CZ2 TRP A 417 −43.308 −55.627 −17.025 1.00 16.31 C ATOM 1363 C TRP A 417 −45.232 −62.461 −18.712 1.00 13.11 C ATOM 1364 O TRP A 417 −46.285 −62.995 −18.385 1.00 14.99 O ATOM 1365 N GLY A 418 −44.166 −63.160 −19.055 1.00 13.45 N ATOM 1366 CA GLY A 418 −44.159 −64.603 −18.858 1.00 10.80 C ATOM 1367 C GLY A 418 −43.286 −64.954 −17.654 1.00 12.58 C ATOM 1368 O GLY A 418 −42.072 −64.723 −17.655 1.00 13.15 O ATOM 1369 N LEU A 419 −43.883 −65.551 −16.643 1.00 11.11 N ATOM 1370 CA LEU A 419 −43.179 −65.666 −15.360 1.00 12.41 C ATOM 1371 CB LEU A 419 −43.931 −64.862 −14.256 1.00 11.30 C ATOM 1372 CG LEU A 419 −44.231 −63.346 −14.510 1.00 11.74 C ATOM 1373 CD1 LEU A 419 −45.115 −62.735 −13.386 1.00 14.81 C ATOM 1374 CD2 LEU A 419 −42.946 −62.531 −14.571 1.00 13.02 C ATOM 1375 C LEU A 419 −42.991 −67.136 −14.975 1.00 13.87 C ATOM 1376 O LEU A 419 −43.896 −67.951 −15.119 1.00 15.45 O ATOM 1377 N THR A 420 −41.807 −67.490 −14.525 1.00 15.12 N ATOM 1378 CA THR A 420 −41.585 −68.881 −14.080 1.00 15.23 C ATOM 1379 CB THR A 420 −40.085 −69.120 −13.917 1.00 18.49 C ATOM 1380 OG1 THR A 420 −39.446 −68.724 −15.142 1.00 15.51 O ATOM 1381 CG2 THR A 420 −39.818 −70.609 −13.604 1.00 18.00 C ATOM 1382 C THR A 420 −42.339 −69.166 −12.777 1.00 17.79 C ATOM 1383 O THR A 420 −42.063 −68.507 −11.734 1.00 16.83 O ATOM 1384 N ARG A 421 −43.301 −70.117 −12.810 1.00 13.41 N ATOM 1385 CA ARG A 421 −44.232 −70.286 −11.664 1.00 17.69 C ATOM 1386 CB ARG A 421 −45.220 −71.433 −11.890 1.00 22.23 C ATOM 1387 CG ARG A 421 −46.292 −71.179 −12.897 1.00 31.08 C ATOM 1388 CD ARG A 421 −47.075 −72.459 −13.197 1.00 41.71 C ATOM 1389 NE ARG A 421 −48.203 −72.193 −14.089 1.00 42.91 N ATOM 1390 CZ ARG A 421 −49.461 −72.013 −13.684 1.00 51.48 C ATOM 1391 NH1 ARG A 421 −49.775 −72.099 −12.395 1.00 48.96 N ATOM 1392 NH2 ARG A 421 −50.411 −71.764 −14.575 1.00 47.16 N ATOM 1393 C ARG A 421 −43.452 −70.627 −10.389 1.00 18.11 C ATOM 1394 O ARG A 421 −43.872 −70.294 −9.275 1.00 20.48 O ATOM 1395 N SER A 422 −42.360 −71.371 −10.549 1.00 17.48 N ATOM 1396 CA SER A 422 −41.601 −71.869 −9.384 1.00 19.10 C ATOM 1397 CB SER A 422 −40.757 −73.098 −9.778 1.00 18.85 C ATOM 1398 OG SER A 422 −39.712 −72.731 −10.659 1.00 29.04 O ATOM 1399 C SER A 422 −40.744 −70.761 −8.755 1.00 18.22 C ATOM 1400 O SER A 422 −40.231 −70.933 −7.658 1.00 16.37 O ATOM 1401 N ALA A 423 −40.645 −69.600 −9.420 1.00 14.40 N ATOM 1402 CA ALA A 423 −39.974 −68.412 −8.827 1.00 14.17 C ATOM 1403 CB ALA A 423 −39.237 −67.612 −9.920 1.00 16.41 C ATOM 1404 C ALA A 423 −40.936 −67.491 −8.063 1.00 13.31 C ATOM 1405 O ALA A 423 −40.542 −66.430 −7.595 1.00 13.94 O ATOM 1406 N LEU A 424 −42.187 −67.893 −7.940 1.00 12.23 N ATOM 1407 CA LEU A 424 −43.195 −67.081 −7.242 1.00 13.18 C ATOM 1408 CB LEU A 424 −44.336 −66.728 −8.207 1.00 12.82 C ATOM 1409 CG LEU A 424 −43.987 −65.811 −9.380 1.00 14.65 C ATOM 1410 CD1 LEU A 424 −45.189 −65.723 −10.333 1.00 17.24 C ATOM 1411 CD2 LEU A 424 −43.713 −64.395 −8.839 1.00 18.67 C ATOM 1412 C LEU A 424 −43.752 −67.875 −6.074 1.00 16.98 C ATOM 1413 O LEU A 424 −43.751 −69.123 −6.091 1.00 16.48 O ATOM 1414 N LEU A 425 −44.216 −67.176 −5.069 1.00 14.07 N ATOM 1415 CA LEU A 425 −44.803 −67.809 −3.906 1.00 21.99 C ATOM 1416 CB LEU A 425 −44.232 −67.138 −2.665 1.00 21.97 C ATOM 1417 CG LEU A 425 −43.608 −67.814 −1.472 1.00 31.87 C ATOM 1418 CD1 LEU A 425 −43.468 −66.716 −0.422 1.00 20.48 C ATOM 1419 CD2 LEU A 425 −44.389 −69.033 −0.964 1.00 31.12 C ATOM 1420 C LEU A 425 −46.377 −67.652 −4.010 1.00 34.82 C ATOM 1421 O LEU A 425 −46.850 −66.703 −4.622 1.00 38.21 O ATOM 1422 N PRO A 426 −47.164 −68.496 −3.298 1.00 41.26 N ATOM 1423 CA PRO A 426 −48.220 −69.302 −3.850 1.00 44.73 C ATOM 1424 CB PRO A 426 −49.415 −68.334 −3.860 1.00 38.18 C ATOM 1425 CG PRO A 426 −49.134 −67.404 −2.690 1.00 50.70 C ATOM 1426 CD PRO A 426 −47.735 −67.745 −2.166 1.00 63.24 C ATOM 1427 C PRO A 426 −47.871 −69.792 −5.238 1.00 54.85 C ATOM 1428 O PRO A 426 −46.919 −70.554 −5.368 1.00 49.22 O ATOM 1429 N THR B 321 −63.112 −67.864 −14.901 1.00 33.78 N ATOM 1430 CA THR B 321 −63.075 −66.430 −15.388 1.00 31.09 C ATOM 1431 CB THR B 321 −61.978 −65.597 −14.690 1.00 28.86 C ATOM 1432 OG1 THR B 321 −60.710 −66.148 −15.012 1.00 30.56 O ATOM 1433 CG2 THR B 321 −62.179 −65.466 −13.138 1.00 26.79 C ATOM 1434 C THR B 321 −62.843 −66.243 −16.930 1.00 27.83 C ATOM 1435 O THR B 321 −62.911 −65.125 −17.415 1.00 28.51 O ATOM 1436 N SER B 322 −62.525 −67.294 −17.681 1.00 24.96 N ATOM 1437 CA SER B 322 −62.224 −67.092 −19.119 1.00 22.39 C ATOM 1438 CB SER B 322 −61.481 −68.277 −19.706 1.00 21.11 C ATOM 1439 OG SER B 322 −60.230 −68.354 −19.125 1.00 25.01 O ATOM 1440 C SER B 322 −63.437 −66.756 −19.998 1.00 24.86 C ATOM 1441 O SER B 322 −64.502 −67.367 −19.877 1.00 22.17 O ATOM 1442 N LEU B 323 −63.244 −65.805 −20.908 1.00 21.57 N ATOM 1443 CA LEU B 323 −64.214 −65.466 −21.921 1.00 19.66 C ATOM 1444 CB LEU B 323 −64.615 −63.993 −21.788 1.00 17.99 C ATOM 1445 CG LEU B 323 −65.210 −63.555 −20.442 1.00 18.68 C ATOM 1446 CD1 LEU B 323 −65.404 −62.051 −20.416 1.00 21.42 C ATOM 1447 CD2 LEU B 323 −66.561 −64.221 −20.268 1.00 27.45 C ATOM 1448 C LEU B 323 −63.599 −65.749 −23.294 1.00 18.51 C ATOM 1449 O LEU B 323 −62.585 −65.155 −23.671 1.00 16.79 O ATOM 1450 N CYS B 324 −64.180 −66.712 −24.001 1.00 22.68 N ATOM 1451 CA CYS B 324 −63.598 −67.231 −25.232 1.00 19.29 C ATOM 1452 CB CYS B 324 −63.475 −68.767 −25.167 1.00 20.03 C ATOM 1453 SG CYS B 324 −62.230 −69.313 −23.967 1.00 23.16 S ATOM 1454 C CYS B 324 −64.400 −66.823 −26.449 1.00 20.35 C ATOM 1455 O CYS B 324 −65.613 −66.568 −26.353 1.00 21.65 O ATOM 1456 N CYS B 325 −63.726 −66.780 −27.599 1.00 16.20 N ATOM 1457 CA CYS B 325 −64.403 −66.646 −28.865 1.00 21.02 C ATOM 1458 CB CYS B 325 −63.383 −66.747 −30.006 1.00 16.21 C ATOM 1459 SG CYS B 325 −64.155 −66.812 −31.626 1.00 21.06 S ATOM 1460 C CYS B 325 −65.497 −67.747 −28.995 1.00 19.82 C ATOM 1461 O CYS B 325 −65.228 −68.938 −28.817 1.00 20.13 O ATOM 1462 N LYS B 326 −66.723 −67.329 −29.296 1.00 24.90 N ATOM 1463 CA LYS B 326 −67.845 −68.259 −29.435 1.00 23.55 C ATOM 1464 CB LYS B 326 −69.154 −67.477 −29.564 1.00 26.30 C ATOM 1465 CG LYS B 326 −70.423 −68.318 −29.483 1.00 31.03 C ATOM 1466 CD LYS B 326 −71.680 −67.456 −29.644 1.00 32.09 C ATOM 1467 CE LYS B 326 −71.884 −66.999 −31.093 1.00 39.28 C ATOM 1468 NZ LYS B 326 −73.207 −66.332 −31.311 1.00 47.98 N ATOM 1469 C LYS B 326 −67.649 −69.199 −30.645 1.00 24.85 C ATOM 1470 O LYS B 326 −68.044 −70.380 −30.603 1.00 23.29 O ATOM 1471 N GLN B 327 −67.012 −68.689 −31.703 1.00 22.42 N ATOM 1472 CA GLN B 327 −66.855 −69.467 −32.956 1.00 19.74 C ATOM 1473 CB GLN B 327 −66.511 −68.551 −34.138 1.00 17.78 C ATOM 1474 CG GLN B 327 −66.322 −69.254 −35.491 1.00 17.05 C ATOM 1475 CD GLN B 327 −67.529 −70.079 −35.918 1.00 21.82 C ATOM 1476 OE1 GLN B 327 −68.672 −69.634 −35.790 1.00 19.63 O ATOM 1477 NE2 GLN B 327 −67.277 −71.296 −36.450 1.00 14.70 N ATOM 1478 C GLN B 327 −65.844 −70.621 −32.820 1.00 19.32 C ATOM 1479 O GLN B 327 −66.217 −71.782 −32.987 1.00 19.00 C ATOM 1480 N CYS B 328 −64.579 −70.319 −32.501 1.00 15.97 N ATOM 1481 CA CYS B 328 −63.535 −71.365 −32.484 1.00 21.42 C ATOM 1482 CB CYS B 328 −62.164 −70.816 −32.947 1.00 17.46 C ATOM 1483 SG CYS B 328 −61.540 −69.481 −31.860 1.00 22.43 S ATOM 1484 C CYS B 328 −63.448 −71.988 −31.095 1.00 21.34 C ATOM 1485 O CYS B 328 −62.766 −73.006 −30.890 1.00 20.25 O ATOM 1486 N GLN B 329 −64.162 −71.386 −30.141 1.00 18.79 N ATOM 1487 CA GLN B 329 −64.326 −71.976 −28.812 1.00 20.39 C ATOM 1488 CB GLN B 329 −65.034 −73.368 −28.888 1.00 23.80 C ATOM 1489 CG GLN B 329 −66.229 −73.470 −29.868 1.00 22.53 C ATOM 1490 CD GLN B 329 −67.041 −74.761 −29.717 1.00 25.79 C ATOM 1491 OE1 GLN B 329 −67.162 −75.297 −28.622 1.00 36.92 O ATOM 1492 NE2 GLN B 329 −67.565 −75.281 −30.829 1.00 22.75 N ATOM 1493 C GLN B 329 −63.000 −72.057 −27.980 1.00 22.95 C ATOM 1494 O GLN B 329 −63.053 −71.996 −26.761 1.00 31.05 O ATOM 1495 N GLU B 330 −61.833 −72.134 −28.640 1.00 26.57 N ATOM 1496 CA GLU B 330 −60.514 −72.430 −27.965 1.00 30.50 C ATOM 1497 CB GLU B 330 −59.518 −73.062 −28.946 1.00 30.59 C ATOM 1498 CG GLU B 330 −59.786 −74.520 −29.335 1.00 50.82 C ATOM 1499 CD GLU B 330 −59.003 −75.523 −28.489 1.00 54.24 C ATOM 1500 OE1 GLU B 330 −59.541 −75.974 −27.453 1.00 64.12 O ATOM 1501 OE2 GLU B 330 −57.860 −75.880 −28.867 1.00 54.69 O ATOM 1502 C GLU B 330 −59.811 −71.182 −27.417 1.00 33.57 C ATOM 1503 O GLU B 330 −58.982 −71.250 −26.499 1.00 29.81 O ATOM 1504 N THR B 331 −60.081 −70.067 −28.052 1.00 20.02 N ATOM 1505 CA THR B 331 −59.249 −68.918 −27.922 1.00 23.19 C ATOM 1506 CB THR B 331 −59.133 −68.233 −29.298 1.00 24.77 C ATOM 1507 OG1 THR B 331 −58.719 −69.211 −30.263 1.00 20.05 O ATOM 1508 CG2 THR B 331 −58.163 −67.086 −29.280 1.00 15.31 C ATOM 1509 C THR B 331 −59.831 −67.975 −26.886 1.00 19.71 C ATOM 1510 O THR B 331 −60.967 −67.444 −27.047 1.00 16.61 O ATOM 1511 N GLU B 332 −59.052 −67.752 −25.828 1.00 16.82 N ATOM 1512 CA GLU B 332 −59.419 −66.809 −24.796 1.00 17.31 C ATOM 1513 CB GLU B 332 −58.542 −66.999 −23.525 1.00 19.58 C ATOM 1514 CG GLU B 332 −59.045 −66.164 −22.375 1.00 17.83 C ATOM 1515 CD GLU B 332 −58.159 −66.232 −21.163 1.00 20.67 C ATOM 1516 OE1 GLU B 332 −58.291 −67.201 −20.407 1.00 18.15 O ATOM 1517 OE2 GLU B 332 −57.330 −65.318 −20.976 1.00 17.34 O ATOM 1518 C GLU B 332 −59.298 −65.383 −25.325 1.00 19.08 C ATOM 1519 O GLU B 332 −58.251 −65.022 −25.850 1.00 21.14 O ATOM 1520 N ILE B 333 −60.349 −64.566 −25.175 1.00 14.52 N ATOM 1521 CA ILE B 333 −60.245 −63.162 −25.639 1.00 15.24 C ATOM 1522 CB ILE B 333 −61.426 −62.759 −26.536 1.00 13.05 C ATOM 1523 CG1 ILE B 333 −61.528 −63.737 −27.743 1.00 17.07 C ATOM 1524 CD1 ILE B 333 −60.466 −63.562 −28.793 1.00 13.55 C ATOM 1525 CG2 ILE B 333 −61.342 −61.271 −26.927 1.00 12.30 C ATOM 1526 C ILE B 333 −60.065 −62.165 −24.489 1.00 17.36 C ATOM 1527 O ILE B 333 −59.322 −61.177 −24.616 1.00 17.79 O ATOM 1528 N THR B 334 −60.723 −62.436 −23.363 1.00 16.75 N ATOM 1529 CA THR B 334 −60.455 −61.642 −22.150 1.00 16.99 C ATOM 1530 CB THR B 334 −61.175 −60.282 −22.242 1.00 15.74 C ATOM 1531 OG1 THR B 334 −60.687 −59.411 −21.224 1.00 23.64 O ATOM 1532 CG2 THR B 334 −62.657 −60.463 −22.131 1.00 14.47 C ATOM 1533 C THR B 334 −60.836 −62.480 −20.909 1.00 15.10 C ATOM 1534 O THR B 334 −61.151 −63.674 −21.037 1.00 13.65 O ATOM 1535 N THR B 335 −60.770 −61.892 −19.722 1.00 14.71 N ATOM 1536 CA THR B 335 −61.224 −62.576 −18.555 1.00 16.76 C ATOM 1537 CB THR B 335 −60.026 −62.971 −17.673 1.00 16.28 C ATOM 1538 OG1 THR B 335 −59.527 −61.792 −17.031 1.00 20.59 O ATOM 1539 CG2 THR B 335 −58.931 −63.586 −18.513 1.00 17.06 C ATOM 1540 C THR B 335 −62.156 −61.674 −17.771 1.00 16.29 C ATOM 1541 O THR B 335 −62.139 −60.455 −17.961 1.00 15.47 O ATOM 1542 N LYS B 336 −62.968 −62.254 −16.892 1.00 15.80 N ATOM 1543 CA LYS B 336 −63.872 −61.446 −16.048 1.00 21.89 C ATOM 1544 CB LYS B 336 −64.715 −62.330 −15.141 1.00 20.64 C ATOM 1545 CG LYS B 336 −65.813 −63.096 −15.864 1.00 28.57 C ATOM 1546 CD LYS B 336 −66.834 −63.608 −14.846 1.00 27.84 C ATOM 1547 CE LYS B 336 −68.199 −63.863 −15.483 1.00 40.86 C ATOM 1548 NZ LYS B 336 −68.961 −64.844 −14.650 1.00 33.79 N ATOM 1549 C LYS B 336 −63.111 −60.439 −15.198 1.00 16.16 C ATOM 1550 O LYS B 336 −63.661 −59.410 −14.804 1.00 16.06 O ATOM 1551 N ASN B 337 −61.854 −60.759 −14.879 1.00 14.67 N ATOM 1552 CA ASN B 337 −61.006 −59.830 −14.097 1.00 17.91 C ATOM 1553 CB ASN B 337 −59.654 −60.466 −13.780 1.00 15.75 C ATOM 1554 CG ASN B 337 −59.788 −61.754 −13.009 1.00 22.24 C ATOM 1555 OD1 ASN B 337 −59.355 −62.790 −13.457 1.00 26.50 O ATOM 1556 ND2 ASN B 337 −60.403 −61.687 −11.851 1.00 34.77 N ATOM 1557 C ASN B 337 −60.783 −58.492 −14.796 1.00 15.80 C ATOM 1558 O ASN B 337 −60.522 −57.495 −14.146 1.00 15.11 O ATOM 1559 N GLU B 338 −60.847 −58.494 −16.135 1.00 16.19 N ATOM 1560 CA GLU B 338 −60.552 −57.299 −16.908 1.00 15.10 C ATOM 1561 CB GLU B 338 −59.921 −57.632 −18.270 1.00 12.81 C ATOM 1562 CG GLU B 338 −58.644 −58.423 −18.153 1.00 15.49 C ATOM 1563 CD GLU B 338 −57.668 −57.767 −17.194 1.00 22.76 C ATOM 1564 OE1 GLU B 338 −57.431 −56.551 −17.299 1.00 18.21 O ATOM 1565 OE2 GLU B 338 −57.147 −58.472 −16.326 1.00 24.45 O ATOM 1566 C GLU B 338 −61.737 −56.372 −17.127 1.00 16.48 C ATOM 1567 O GLU B 338 −61.555 −55.267 −17.656 1.00 16.22 O ATOM 1568 N ILE B 339 −62.939 −56.811 −16.734 1.00 15.07 N ATOM 1569 CA ILE B 339 −64.160 −56.004 −16.969 1.00 17.10 C ATOM 1570 CB ILE B 339 −64.456 −56.823 −16.669 1.00 23.04 C ATOM 1571 CG1 ILE B 339 −65.586 −58.054 −17.617 1.00 23.48 C ATOM 1572 CD1 ILE B 339 −66.528 −59.156 −17.092 1.00 20.03 C ATOM 1573 CG2 ILE B 339 −66.711 −55.917 −16.754 1.00 19.16 C ATOM 1574 C ILE B 339 −64.150 −54.762 −16.109 1.00 18.73 C ATOM 1575 O ILE B 339 −63.706 −54.811 −14.934 1.00 17.53 O ATOM 1576 N PHE B 340 −64.628 −53.645 −16.692 1.00 11.72 N ATOM 1577 CA PHE B 340 −64.810 −52.406 −16.010 1.00 16.33 C ATOM 1578 CB PHE B 340 −63.548 −51.493 −16.034 1.00 13.18 C ATOM 1579 CG PHE B 340 −63.303 −50.823 −17.348 1.00 15.25 C ATOM 1580 CD1 PHE B 340 −63.510 −49.455 −17.479 1.00 13.45 C ATOM 1581 CE1 PHE B 340 −63.272 −48.798 −18.694 1.00 12.40 C ATOM 1582 CZ PHE B 340 −62.799 −49.516 −19.797 1.00 9.99 C ATOM 1583 CE2 PHE B 340 −62.533 −50.901 −19.680 1.00 11.53 C ATOM 1584 CD2 PHE B 340 −62.778 −51.553 −18.468 1.00 12.25 C ATOM 1585 C PHE B 340 −65.987 −51.686 −16.673 1.00 16.55 C ATOM 1586 O PHE B 340 −66.451 −52.083 −17.781 1.00 15.69 O ATOM 1587 N SER B 341 −66.430 −50.627 −16.026 1.00 15.87 N ATOM 1588 CA SER B 341 −67.627 −49.896 −16.474 1.00 18.61 C ATOM 1589 CB SER B 341 −68.703 −49.887 −15.389 1.00 23.05 C ATOM 1590 OG SER B 341 −69.958 −49.458 −15.936 1.00 26.64 O ATOM 1591 C SER B 341 −67.295 −48.496 −16.884 1.00 18.03 C ATOM 1592 O SER B 341 −67.003 −47.650 −16.051 1.00 21.76 O ATOM 1593 N LEU B 342 −67.257 −48.268 −18.200 1.00 25.29 N ATOM 1594 CA LEU B 342 −66.943 −46.952 −18.766 1.00 23.64 C ATOM 1595 CB LEU B 342 −66.494 −47.069 −20.251 1.00 28.34 C ATOM 1596 CG LEU B 342 −65.626 −46.023 −20.981 1.00 28.10 C ATOM 1597 CD1 LEU B 342 −66.397 −44.772 −21.307 1.00 30.47 C ATOM 1598 CD2 LEU B 342 −64.405 −45.646 −20.146 1.00 35.50 C ATOM 1599 C LEU B 342 −68.126 −46.013 −18.583 1.00 29.99 C ATOM 1600 O LEU B 342 −67.967 −44.889 −18.046 1.00 25.51 O ATOM 1601 N SER B 343 −69.328 −46.483 −18.945 1.00 28.47 N ATOM 1602 CA SER B 343 −70.510 −45.602 −18.994 1.00 39.38 C ATOM 1603 CB SER B 343 −71.711 −46.304 −19.676 1.00 43.93 C ATOM 1604 OG SER B 343 −71.699 −47.691 −19.422 1.00 40.39 O ATOM 1605 C SER B 343 −70.919 −44.900 −17.658 1.00 41.75 C ATOM 1606 O SER B 343 −71.705 −45.423 −16.855 1.00 35.22 O ATOM 1607 N GLU B 360 −74.896 −55.104 −23.982 1.00 32.15 N ATOM 1608 CA GLU B 360 −74.565 −55.568 −25.345 1.00 40.50 C ATOM 1609 CB GLU B 360 −75.210 −54.647 −26.398 1.00 42.12 C ATOM 1610 CG GLU B 360 −74.822 −54.947 −27.844 1.00 42.69 C ATOM 1611 CD GLU B 360 −75.585 −56.117 −28.434 1.00 48.38 C ATOM 1612 OE1 GLU B 360 −75.164 −56.625 −29.497 1.00 60.27 O ATOM 1613 OE2 GLU B 360 −76.598 −56.536 −27.839 1.00 61.10 O ATOM 1614 C GLU B 360 −73.054 −55.643 −25.598 1.00 39.19 C ATOM 1615 O GLU B 360 −72.555 −56.586 −26.271 1.00 26.18 O ATOM 1616 N THR B 361 −72.356 −54.607 −25.123 1.00 26.11 N ATOM 1617 CA THR B 361 −70.917 −54.413 −25.355 1.00 30.60 C ATOM 1618 CB THR B 361 −70.628 −53.059 −26.040 1.00 38.10 C ATOM 1619 OG1 THR B 361 −71.157 −53.093 −27.370 1.00 55.54 O ATOM 1620 CG2 THR B 361 −69.125 −52.773 −26.111 1.00 28.78 C ATOM 1621 C THR B 361 −70.201 −54.458 −24.013 1.00 24.67 C ATOM 1622 O THR B 361 −70.417 −53.620 −23.177 1.00 26.55 O ATOM 1623 N LEU B 362 −69.384 −55.470 −23.821 1.00 19.02 N ATOM 1624 CA LEU B 362 −68.602 −55.638 −22.612 1.00 16.98 C ATOM 1625 CB LEU B 362 −68.219 −57.109 −22.546 1.00 17.61 C ATOM 1626 CG LEU B 362 −67.577 −57.688 −21.312 1.00 22.51 C ATOM 1627 CD1 LEU B 362 −68.528 −57.625 −20.123 1.00 18.25 C ATOM 1628 CD2 LEU B 362 −67.165 −59.114 −21.647 1.00 21.01 C ATOM 1629 C LEU B 362 −67.339 −54.757 −22.750 1.00 16.19 C ATOM 1630 O LEU B 362 −66.675 −54.780 −23.788 1.00 17.80 O ATOM 1631 N THR B 363 −66.986 −53.989 −21.727 1.00 15.48 N ATOM 1632 CA THR B 363 −65.724 −53.230 −21.828 1.00 13.14 C ATOM 1633 CB THR B 363 −65.952 −51.711 −21.636 1.00 13.68 C ATOM 1634 OG1 THR B 363 −66.562 −54.488 −20.359 1.00 15.25 O ATOM 1635 CG2 THR B 363 −66.880 −51.169 −22.740 1.00 15.60 C ATOM 1636 C THR B 363 −64.665 −53.785 −20.889 1.00 15.29 C ATOM 1637 O THR B 363 −64.928 −54.019 −19.666 1.00 13.39 O ATOM 1638 N VAL B 364 −63.470 −53.985 −21.431 1.00 11.88 N ATOM 1639 CA VAL B 364 −62.397 −54.633 −20.669 1.00 12.70 C ATOM 1640 CB VAL B 364 −62.222 −56.157 −21.031 1.00 14.95 C ATOM 1641 CG1 VAL B 364 −63.465 −56.991 −20.646 1.00 14.46 C ATOM 1642 CG2 VAL B 364 −61.801 −56.385 −22.501 1.00 11.34 C ATOM 1643 C VAL B 364 −61.116 −53.868 −20.870 1.00 13.19 C ATOM 1644 O VAL B 364 −60.913 −53.230 −21.942 1.00 10.72 O ATOM 1645 N TYR B 365 −60.249 −53.875 −19.834 1.00 12.47 N ATOM 1646 CA TYR B 365 −59.029 −53.088 −19.900 1.00 11.95 C ATOM 1647 CB TYR B 365 −58.393 −52.934 −18.478 1.00 10.06 C ATOM 1648 CG TYR B 365 −59.068 −51.902 −17.566 1.00 9.95 C ATOM 1649 CD1 TYR B 365 −59.117 −50.551 −17.921 1.00 9.17 C ATOM 1650 CE1 TYR B 365 −59.706 −49.610 −17.076 1.00 10.71 C ATOM 1651 CZ TYR B 365 −60.241 −50.039 −15.861 1.00 12.14 C ATOM 1652 OH TYR B 365 −60.815 −49.124 −15.007 1.00 10.17 O ATOM 1653 CE2 TYR B 365 −60.194 −51.390 −15.499 1.00 10.44 C ATOM 1654 CD2 TYR B 365 −59.622 −52.297 −16.367 1.00 9.33 C ATOM 1655 C TYR B 365 −57.997 −53.745 −20.838 1.00 12.87 C ATOM 1656 O TYR B 365 −57.152 −53.062 −21.430 1.00 13.23 O ATOM 1657 N LYS B 366 −58.064 −55.076 −20.943 1.00 10.50 N ATOM 1658 CA LYS B 366 −57.044 −55.842 −21.588 1.00 12.58 C ATOM 1659 CB LYS B 366 −56.060 −56.412 −20.513 1.00 12.47 C ATOM 1660 CG LYS B 366 −55.114 −55.400 −19.901 1.00 13.02 C ATOM 1661 CD LYS B 366 −53.955 −55.298 −20.920 1.00 17.19 C ATOM 1662 CE LYS B 366 −52.989 −54.194 −20.639 1.00 22.40 C ATOM 1663 NZ LYS B 366 −52.022 −54.148 −21.770 1.00 11.57 N ATOM 1664 C LYS B 366 −57.716 −57.024 −22.293 1.00 11.90 C ATOM 1665 O LYS B 366 −58.726 −57.577 −21.808 1.00 14.08 O ATOM 1666 N ALA B 367 −57.139 −57.434 −23.404 1.00 11.40 N ATOM 1667 CA ALA B 367 −57.693 −58.571 −24.164 1.00 12.16 C ATOM 1668 CB ALA B 367 −58.746 −58.076 −25.162 1.00 12.10 C ATOM 1669 C ALA B 367 −56.549 −59.250 −24.873 1.00 12.33 C ATOM 1670 O ALA B 367 −55.424 −58.709 −24.930 1.00 11.65 O ATOM 1671 N SER B 368 −56.812 −60.440 −25.427 1.00 12.83 N ATOM 1672 CA SER B 368 −55.744 −61.223 −26.019 1.00 15.64 C ATOM 1673 CB SER B 368 −55.277 −62.283 −25.002 1.00 14.92 C ATOM 1674 OG SER B 368 −56.375 −63.056 −24.552 1.00 14.79 O ATOM 1675 C SER B 368 −56.208 −61.939 −27.289 1.00 16.06 C ATOM 1676 O SER B 368 −57.434 −62.190 −27.475 1.00 15.79 O ATOM 1677 N ASN B 369 −55.243 −62.283 −28.143 1.00 15.87 N ATOM 1678 CA ASN B 369 −55.503 −63.156 −29.288 1.00 19.46 C ATOM 1679 CB ASN B 369 −56.080 −64.473 −28.803 1.00 15.83 C ATOM 1680 CG ASN B 369 −55.154 −65.200 −27.867 1.00 20.08 C ATOM 1681 OD1 ASN B 369 −55.593 −65.737 −26.873 1.00 24.87 O ATOM 1682 ND2 ASN B 369 −53.872 −65.225 −28.184 1.00 15.96 N ATOM 1683 C ASN B 369 −56.473 −62.503 −30.284 1.00 20.41 C ATOM 1684 O ASN B 369 −57.215 −63.198 −31.016 1.00 20.86 O ATOM 1685 N LEU B 370 −56.477 −61.166 −30.280 1.00 17.87 N ATOM 1686 CA LEU B 370 −57.196 −60.381 −31.304 1.00 20.24 C ATOM 1687 CB LEU B 370 −58.031 −59.259 −30.660 1.00 17.03 C ATOM 1688 CG LEU B 370 −59.210 −59.705 −29.784 1.00 19.14 C ATOM 1689 CD1 LEU B 370 −59.676 −58.552 −28.860 1.00 17.00 C ATOM 1690 CD2 LEU B 370 −60.370 −60.220 −30.642 1.00 15.59 C ATOM 1691 C LEU B 370 −56.226 −59.817 −32.338 1.00 18.63 C ATOM 1692 O LEU B 370 −55.111 −59.397 −31.984 1.00 16.57 O ATOM 1693 N ASN B 371 −56.637 −59.881 −33.616 1.00 19.09 N ATOM 1694 CA ASN B 371 −56.005 −59.098 −34.733 1.00 24.20 C ATOM 1695 CB ASN B 371 −56.069 −59.866 −36.081 1.00 26.07 C ATOM 1696 CG ASN B 371 −54.844 −60.701 −36.343 1.00 37.87 C ATOM 1697 OD1 ASN B 371 −54.942 −61.906 −36.610 1.00 40.52 O ATOM 1698 ND2 ASN B 371 −53.674 −60.068 −36.287 1.00 49.08 N ATOM 1699 C ASN B 371 −56.743 −57.793 −34.967 1.00 26.33 C ATOM 1700 O ASN B 371 −57.987 −57.800 −35.061 1.00 21.32 O ATOM 1701 N LEU B 372 −55.975 −56.714 −35.151 1.00 19.03 N ATOM 1702 CA LEU B 372 −56.516 −55.388 −35.479 1.00 21.23 C ATOM 1703 CB LEU B 372 −55.669 −54.255 −34.842 1.00 15.54 C ATOM 1704 CG LEU B 372 −55.629 −54.317 −33.309 1.00 20.87 C ATOM 1705 CD1 LEU B 372 −54.508 −53.457 −32.742 1.00 18.28 C ATOM 1706 CD2 LEU B 372 −56.984 −53.987 −32.686 1.00 20.53 C ATOM 1707 C LEU B 372 −56.517 −55.215 −36.963 1.00 21.31 C ATOM 1708 O LEU B 372 −55.472 −55.377 −37.603 1.00 21.11 O ATOM 1709 N ILE B 373 −57.682 −54.845 −37.499 1.00 21.66 N ATOM 1710 CA ILE B 373 −57.879 −54.654 −38.950 1.00 23.75 C ATOM 1711 CB ILE B 373 −59.223 −55.238 −39.403 1.00 23.03 C ATOM 1712 CG1 ILE B 373 −59.311 −56.738 −39.086 1.00 25.33 C ATOM 1713 CD1 ILE B 373 −58.223 −57.565 −39.748 1.00 32.29 C ATOM 1714 CG2 ILE B 373 −59.476 −54.951 −40.892 1.00 26.69 C ATOM 1715 C ILE B 373 −57.996 −53.164 −39.160 1.00 28.35 C ATOM 1716 O ILE B 373 −58.913 −52.544 −38.615 1.00 25.31 O ATOM 1717 N GLY B 374 −57.086 −52.575 −39.929 1.00 27.91 N ATOM 1718 CA GLY B 374 −57.239 −51.159 −40.312 1.00 31.00 C ATOM 1719 C GLY B 374 −56.656 −50.157 −39.322 1.00 36.32 C ATOM 1720 O GLY B 374 −55.905 −50.514 −38.417 1.00 32.64 O ATOM 1721 N ARG B 375 −56.987 −48.890 −39.517 1.00 36.50 N ATOM 1722 CA ARG B 375 −56.502 −47.829 −38.643 1.00 37.55 C ATOM 1723 CB ARG B 375 −55.740 −46.764 −39.454 1.00 43.97 C ATOM 1724 CG ARG B 375 −56.126 −46.700 −40.929 1.00 54.49 C ATOM 1725 CD ARG B 375 −54.992 −46.194 −41.805 1.00 57.39 C ATOM 1726 NE ARG B 375 −54.383 −44.969 −41.279 1.00 76.97 N ATOM 1727 CZ ARG B 375 −54.863 −43.738 −41.462 1.00 75.86 C ATOM 1728 NH1 ARG B 375 −55.980 −43.541 −42.160 1.00 82.58 N ATOM 1729 NH2 ARG B 375 −54.222 −42.701 −40.942 1.00 58.97 N ATOM 1730 C ARG B 375 −57.668 −47.224 −37.843 1.00 27.00 C ATOM 1731 O ARG B 375 −58.827 −47.398 −38.209 1.00 30.03 O ATOM 1732 N PRO B 376 −57.368 −46.558 −36.727 1.00 29.10 N ATOM 1733 CA PRO B 376 −58.428 −45.966 −35.869 1.00 26.59 C ATOM 1734 CB PRO B 376 −57.623 −45.149 −34.861 1.00 25.76 C ATOM 1735 CG PRO B 376 −56.320 −45.906 −34.736 1.00 29.31 C ATOM 1736 CD PRO B 376 −56.034 −46.483 −36.101 1.00 28.59 C ATOM 1737 C PRO B 376 −59.425 −45.045 −36.619 1.00 24.43 C ATOM 1738 O PRO B 376 −59.012 −44.338 −37.517 1.00 27.57 O ATOM 1739 N SER B 377 −60.713 −45.065 −36.262 1.00 18.50 N ATOM 1740 CA SER B 377 −61.681 −44.033 −36.774 1.00 18.67 C ATOM 1741 CB SER B 377 −62.628 −44.612 −37.862 1.00 18.16 C ATOM 1742 OG SER B 377 −63.670 −43.675 −38.178 1.00 19.72 O ATOM 1743 C SER B 377 −62.528 −43.491 −35.637 1.00 16.08 C ATOM 1744 O SER B 377 −62.887 −44.219 −34.730 1.00 16.76 O ATOM 1745 N THR B 378 −62.925 −42.244 −35.711 1.00 12.90 N ATOM 1746 CA THR B 378 −63.819 −41.745 −34.698 1.00 13.73 C ATOM 1747 CB THR B 378 −63.420 −40.332 −34.265 1.00 14.94 C ATOM 1748 OG1 THR B 378 −63.411 −39.537 −35.415 1.00 15.24 O ATOM 1749 CG2 THR B 378 −61.966 −40.317 −33.644 1.00 12.79 C ATOM 1750 C THR B 378 −65.280 −41.722 −35.171 1.00 18.42 C ATOM 1751 O THR B 378 −66.167 −41.337 −34.412 1.00 16.86 O ATOM 1752 N VAL B 379 −65.522 −42.103 −36.421 1.00 17.21 N ATOM 1753 CA VAL B 379 −66.856 −41.915 −37.018 1.00 20.80 C ATOM 1754 CB VAL B 379 −66.828 −42.179 −38.535 1.00 22.27 C ATOM 1755 CG1 VAL B 379 −68.188 −41.849 −39.168 1.00 18.88 C ATOM 1756 CG2 VAL B 379 −65.733 −41.310 −39.179 1.00 27.51 C ATOM 1757 C VAL B 379 −67.845 −42.838 −36.325 1.00 16.02 C ATOM 1758 O VAL B 379 −67.561 −44.013 −36.149 1.00 15.55 O ATOM 1759 N HIS B 380 −68.963 −42.283 −35.861 1.00 15.24 N ATOM 1760 CA HIS B 380 −69.986 −43.064 −35.127 1.00 15.62 C ATOM 1761 CB HIS B 380 −70.677 −44.067 −36.058 1.00 15.16 C ATOM 1762 CG HIS B 380 −71.195 −43.423 −37.332 1.00 17.94 C ATOM 1763 ND1 HIS B 380 −71.902 −42.258 −37.320 1.00 16.30 N ATOM 1764 CE1 HIS B 380 −72.175 −41.905 −38.586 1.00 19.92 C ATOM 1765 NE2 HIS B 380 −71.630 −42.824 −39.402 1.00 15.57 N ATOM 1766 CD2 HIS B 380 −71.006 −43.757 −38.661 1.00 15.75 C ATOM 1767 C HIS B 380 −69.443 −43.777 −33.906 1.00 18.74 C ATOM 1768 O HIS B 380 −70.040 −44.764 −33.444 1.00 18.02 O ATOM 1769 N SER B 381 −68.350 −43.266 −33.319 1.00 16.32 N ATOM 1770 CA SER B 381 −67.821 −43.931 −32.107 1.00 17.67 C ATOM 1771 CB SER B 381 −66.573 −43.227 −31.567 1.00 19.31 C ATOM 1772 OG SER B 381 −66.156 −43.939 −30.400 1.00 20.33 O ATOM 1773 C SER B 381 −68.900 −44.026 −30.984 1.00 15.41 C ATOM 1774 O SER B 381 −69.533 −43.040 −30.648 1.00 17.37 O ATOM 1775 N TRP B 382 −69.086 −45.202 −30.406 1.00 13.57 N ATOM 1776 CA TRP B 382 −70.024 −45.347 −29.290 1.00 16.72 C ATOM 1777 CB TRP B 382 −70.325 −46.822 −29.042 1.00 18.77 C ATOM 1778 CG TRP B 382 −70.944 −47.508 −30.247 1.00 18.00 C ATOM 1779 CD1 TRP B 382 −71.869 −46.953 −31.167 1.00 20.24 C ATOM 1780 NE1 TRP B 382 −72.219 −47.879 −32.123 1.00 20.52 N ATOM 1781 CE2 TRP B 382 −71.572 −49.056 −31.889 1.00 18.52 C ATOM 1782 CD2 TRP B 382 −70.747 −48.872 −30.675 1.00 17.19 C ATOM 1783 CE3 TRP B 382 −69.977 −49.945 −30.212 1.00 16.96 C ATOM 1784 CZ3 TRP B 382 −70.050 −51.162 −30.908 1.00 16.35 C ATOM 1785 CH2 TRP B 382 −70.841 −51.313 −32.073 1.00 19.62 C ATOM 1786 CZ2 TRP B 382 −71.624 −50.260 −32.570 1.00 21.06 C ATOM 1787 C TRP B 382 −69.505 −44.726 −28.014 1.00 18.47 C ATOM 1788 O TRP B 382 −70.272 −44.519 −27.060 1.00 20.72 O ATOM 1789 N PHE B 383 −68.215 −44.399 −27.979 1.00 15.41 N ATOM 1790 CA PHE B 383 −67.601 −43.842 −26.728 1.00 16.33 C ATOM 1791 CB PHE B 383 −66.632 −44.840 −26.112 1.00 14.32 C ATOM 1792 CG PHE B 383 −67.259 −46.178 −25.795 1.00 14.32 C ATOM 1793 CD1 PHE B 383 −67.936 −46.377 −24.588 1.00 18.40 C ATOM 1794 CE1 PHE B 383 −68.513 −47.605 −24.291 1.00 17.95 C ATOM 1795 CZ PHE B 383 −68.377 −48.666 −25.198 1.00 20.05 C ATOM 1796 CE2 PHE B 383 −67.659 −48.479 −26.388 1.00 17.26 C ATOM 1797 CD2 PHE B 383 −67.112 −47.242 −26.668 1.00 15.03 C ATOM 1798 C PHE B 383 −66.904 −42.530 −27.061 1.00 19.09 C ATOM 1799 O PHE B 383 −65.771 −42.534 −27.517 1.00 17.94 O ATOM 1800 N PRO B 384 −67.631 −41.400 −26.924 1.00 23.97 N ATOM 1801 CA PRO B 384 −67.092 −40.129 −27.341 1.00 22.32 C ATOM 1802 CB PRO B 384 −68.148 −39.120 −26.826 1.00 29.25 C ATOM 1803 CG PRO B 384 −69.435 −39.893 −26.888 1.00 27.44 C ATOM 1804 CD PRO B 384 −69.038 −41.282 −26.462 1.00 26.09 C ATOM 1805 C PRO B 384 −65.732 −39.884 −26.690 1.00 20.88 C ATOM 1806 O PRO B 384 −65.531 −40.205 −25.500 1.00 18.24 O ATOM 1807 N GLY B 385 −64.806 −39.351 −27.483 1.00 18.55 N ATOM 1808 CA GLY B 385 −63.431 −39.156 −27.072 1.00 16.13 C ATOM 1809 C GLY B 385 −62.544 −40.331 −27.435 1.00 18.13 C ATOM 1810 O GLY B 385 −61.323 −40.247 −27.247 1.00 17.52 O ATOM 1811 N TYR B 386 −63.122 −41.425 −28.001 1.00 13.55 N ATOM 1812 CA TYR B 386 −62.306 −42.590 −28.380 1.00 15.15 C ATOM 1813 CB TYR B 386 −62.639 −43.848 −27.532 1.00 14.09 C ATOM 1814 CG TYR B 386 −62.267 −43.775 −26.049 1.00 13.52 C ATOM 1815 CD1 TYR B 386 −61.013 −44.211 −25.602 1.00 13.02 C ATOM 1816 CE1 TYR B 386 −60.673 −44.146 −24.259 1.00 11.97 C ATOM 1817 CZ TYR B 386 −61.584 −43.648 −23.355 1.00 13.23 C ATOM 1818 OH TYR B 386 −61.222 −43.608 −22.033 1.00 15.62 O ATOM 1819 CE2 TYR B 386 −62.843 −43.222 −23.750 1.00 13.31 C ATOM 1820 CD2 TYR B 386 −63.176 −43.275 −25.099 1.00 14.59 C ATOM 1821 C TYR B 386 −62.480 −42.916 −29.867 1.00 18.68 C ATOM 1822 O TYR B 386 −63.568 −42.710 −30.420 1.00 15.92 O ATOM 1823 N ALA B 387 −61.401 −43.395 −30.502 1.00 18.13 N ATOM 1824 CA ALA B 387 −61.457 −43.939 −31.871 1.00 18.94 C ATOM 1825 CB ALA B 387 −60.231 −43.490 −32.657 1.00 17.27 C ATOM 1826 C ALA B 387 −61.534 −45.467 −31.793 1.00 19.79 C ATOM 1827 O ALA B 387 −61.060 −46.026 −30.836 1.00 19.52 O ATOM 1828 N TRP B 388 −62.148 −46.137 −32.780 1.00 16.53 N ATOM 1829 CA TRP B 388 −62.231 −47.606 −32.786 1.00 17.90 C ATOM 1830 CB TRP B 388 −63.683 −48.084 −32.921 1.00 15.82 C ATOM 1831 CG TRP B 388 −64.431 −47.437 −34.090 1.00 15.10 C ATOM 1832 CD1 TRP B 388 −65.223 −46.310 −34.049 1.00 17.19 C ATOM 1833 NE1 TRP B 388 −65.741 −46.024 −35.309 1.00 17.72 N ATOM 1834 CE2 TRP B 388 −65.306 −46.921 −36.216 1.00 18.04 C ATOM 1835 CD2 TRP B 388 −64.465 −47.875 −35.507 1.00 16.49 C ATOM 1836 CE3 TRP B 388 −63.907 −48.951 −36.225 1.00 19.33 C ATOM 1837 CZ3 TRP B 388 −64.181 −49.047 −37.620 1.00 22.48 C ATOM 1838 CH2 TRP B 388 −64.990 −48.101 −38.272 1.00 19.40 C ATOM 1839 CZ2 TRP B 388 −65.584 −47.039 −37.588 1.00 18.40 C ATOM 1840 C TRP B 388 −61.430 −48.3194 −33.918 1.00 16.80 C ATOM 1841 O TRP B 388 −61.216 −47.544 −34.934 1.00 17.91 O ATOM 1842 N THR B 389 −60.972 −49.428 −33.719 1.00 15.59 N ATOM 1843 CA THR B 389 −60.308 −50.259 −34.740 1.00 17.23 C ATOM 1844 CB THR B 389 −58.800 −50.393 −34.425 1.00 17.76 C ATOM 1845 OG1 THR B 389 −58.200 −49.079 −34.352 1.00 16.72 O ATOM 1846 CG2 THR B 389 −58.067 −51.286 −35.465 1.00 22.12 C ATOM 1847 C THR B 389 −60.935 −51.659 −34.609 1.00 18.46 C ATOM 1848 O THR B 389 −61.019 −52.181 −33.509 1.00 15.15 O ATOM 1849 N ILE B 390 −61.427 −52.236 −35.716 1.00 15.53 N ATOM 1850 CA ILE B 390 −62.040 −53.567 −35.690 1.00 16.52 C ATOM 1851 CB ILE B 390 −62.497 −54.034 −37.113 1.00 18.17 C ATOM 1852 CG1 ILE B 390 −63.598 −53.100 −37.657 1.00 17.97 C ATOM 1853 CD1 ILE B 390 −63.883 −53.294 −39.166 1.00 19.51 C ATOM 1854 CG2 ILE B 390 −63.022 −55.452 −37.055 1.00 18.30 C ATOM 1855 C ILE B 390 −61.080 −54.603 −35.120 1.00 14.85 C ATOM 1856 O ILE B 390 −59.880 −54.589 −35.450 1.00 15.32 O ATOM 1857 N ALA B 391 −61.591 −55.490 −34.255 1.00 12.98 N ATOM 1858 CA ALA B 391 −60.735 −56.512 −33.630 1.00 15.31 C ATOM 1859 CB ALA B 391 −60.539 −56.241 −32.109 1.00 12.99 C ATOM 1860 C ALA B 391 −61.385 −57.882 −33.874 1.00 15.53 C ATOM 1861 O ALA B 391 −62.569 −58.124 −33.516 1.00 17.70 O ATOM 1862 N GLN B 392 −60.623 −58.763 −34.501 1.00 18.76 N ATOM 1863 CA GLN B 392 −61.102 −60.112 −34.828 1.00 20.41 C ATOM 1864 CB GLN B 392 −61.094 −60.315 −36.361 1.00 19.67 C ATOM 1865 CG GLN B 392 −59.702 −60.157 −36.978 1.00 19.70 C ATOM 1866 CD GLN B 392 −59.663 −60.426 −38.484 1.00 29.11 C ATOM 1867 OE1 GLN B 392 −60.694 −60.503 −39.147 1.00 31.58 O ATOM 1868 NE2 GLN B 392 −58.468 −60.557 −39.019 1.00 29.79 N ATOM 1869 C GLN B 392 −60.256 −61.223 −34.155 1.00 20.19 C ATOM 1870 O GLN B 392 −59.051 −61.089 −33.995 1.00 22.80 O ATOM 1871 N CYS B 393 −60.890 −62.356 −33.853 1.00 19.02 N ATOM 1872 CA CYS B 393 −60.165 −63.510 −33.354 1.00 19.57 C ATOM 1873 CB CYS B 393 −61.126 −64.683 −33.180 1.00 21.00 C ATOM 1874 SG CYS B 393 −60.330 −66.166 −32.549 1.00 22.30 S ATOM 1875 C CYS B 393 −59.034 −63.884 −34.325 1.00 20.02 C ATOM 1876 O CYS B 393 −59.289 −64.083 −35.515 1.00 24.83 O ATOM 1877 N LYS B 394 −57.807 −63.967 −33.813 1.00 20.06 N ATOM 1878 CA LYS B 394 −56.634 −64.377 −34.592 1.00 19.72 C ATOM 1879 CB LYS B 394 −55.341 −64.216 −33.777 1.00 18.32 C ATOM 1880 CG LYS B 394 −55.039 −65.385 −32.838 1.00 16.36 C ATOM 1881 CD LYS B 394 −53.772 −65.188 −32.028 1.00 18.08 C ATOM 1882 CE LYS B 394 −53.405 −66.457 −31.278 1.00 16.92 C ATOM 1883 NZ LYS B 394 −52.266 −66.110 −30.408 1.00 21.47 N ATOM 1884 C LYS B 394 −56.724 −65.822 −35.157 1.00 18.13 C ATOM 1885 O LYS B 394 −56.075 −66.123 −36.167 1.00 12.90 O ATOM 1886 N ILE B 395 −57.511 −66.688 −34.517 1.00 15.63 N ATOM 1887 CA ILE B 395 −57.695 −68.077 −35.011 1.00 21.55 C ATOM 1888 CB ILE B 395 −58.005 −69.099 −33.857 1.00 19.97 C ATOM 1889 CG1 ILE B 395 −56.825 −69.232 −32.856 1.00 20.90 C ATOM 1890 CD1 ILE B 395 −55.541 −69.833 −33.405 1.00 23.87 C ATOM 1891 CG2 ILE B 395 −58.464 −70.460 −34.410 1.00 22.20 C ATOM 1892 C ILE B 395 −58.775 −68.219 −36.137 1.00 19.25 C ATOM 1893 O ILE B 395 −58.557 −68.868 −37.148 1.00 21.59 O ATOM 1894 N CYS B 396 −59.944 −67.651 −35.928 1.00 21.06 N ATOM 1895 CA CYS B 396 −61.058 −67.925 −36.827 1.00 18.45 C ATOM 1896 CB CYS B 396 −62.204 −68.608 −36.062 1.00 19.51 C ATOM 1897 SG CYS B 396 −63.158 −67.498 −34.999 1.00 15.41 S ATOM 1898 C CYS B 396 −61.547 −66.684 −37.538 1.00 15.72 C ATOM 1899 O CYS B 396 −62.482 −66.756 −38.345 1.00 18.77 O ATOM 1900 N ALA B 397 −60.888 −65.556 −37.274 1.00 18.08 N ATOM 1901 CA ALA B 397 −61.233 −64.227 −37.861 1.00 17.44 C ATOM 1902 CB ALA B 397 −60.887 −64.160 −39.352 1.00 20.70 C ATOM 1903 C ALA B 397 −62.661 −63.729 −37.597 1.00 21.08 C ATOM 1904 O ALA B 397 −63.096 −62.741 −38.199 1.00 23.11 O ATOM 1905 N SER B 398 −63.367 −64.374 −36.661 1.00 19.81 N ATOM 1906 CA SER B 398 −64.669 −63.889 −36.218 1.00 20.23 C ATOM 1907 CB SER B 398 −65.286 −64.872 −35.216 1.00 23.35 C ATOM 1908 OG SER B 398 −66.388 −64.306 −34.505 1.00 32.78 O ATOM 1909 C SER B 398 −64.523 −62.476 −35.612 1.00 21.34 C ATOM 1910 O SER B 398 −63.582 −62.213 −34.848 1.00 16.15 O ATOM 1911 N HIS B 399 −65.405 −61.552 −36.007 1.00 20.25 N ATOM 1912 CA HIS B 399 −65.327 −60.141 −35.525 1.00 20.47 C ATOM 1913 CB HIS B 399 −66.172 −59.200 −36.401 1.00 24.87 C ATOM 1914 CG HIS B 399 −65.501 −58.780 −37.735 1.00 28.78 C ATOM 1915 ND1 HIS B 399 −64.658 −59.592 −38.440 1.00 32.93 N ATOM 1916 CE1 HIS B 399 −64.248 −58.952 −39.564 1.00 25.71 C ATOM 1917 NE2 HIS B 399 −64.842 −57.774 −39.603 1.00 32.33 N ATOM 1918 CD2 HIS B 399 −65.662 −57.598 −38.496 1.00 28.84 C ATOM 1919 C HIS B 399 −65.784 −60.083 −34.091 1.00 20.30 C ATOM 1920 O HIS B 399 −66.959 −60.271 −33.792 1.00 22.11 O ATOM 1921 N ILE B 400 −64.863 −59.582 −33.163 1.00 19.61 N ATOM 1922 CA ILE B 400 −65.266 −59.899 −31.759 1.00 21.86 C ATOM 1923 CB ILE B 400 −64.165 −60.512 −30.849 1.00 22.15 C ATOM 1924 CG1 ILE B 400 −63.665 −61.850 −31.422 1.00 26.77 C ATOM 1925 CD1 ILE B 400 −64.653 −63.002 −31.362 1.00 26.26 C ATOM 1926 CG2 ILE B 400 −64.662 −60.632 −29.408 1.00 20.54 C ATOM 1927 C ILE B 400 −65.686 −58.535 −31.241 1.00 16.33 C ATOM 1928 O ILE B 400 −66.556 −58.423 −30.380 1.00 19.94 O ATOM 1929 N GLY B 401 −65.034 −57.500 −31.735 1.00 16.07 N ATOM 1930 CA GLY B 401 −65.278 −56.180 −31.212 1.00 17.87 C ATOM 1931 C GLY B 401 −64.356 −55.146 −31.790 1.00 16.14 C ATOM 1932 O GLY B 401 −64.092 −55.137 −32.989 1.00 14.44 O ATOM 1933 N TRP B 402 −63.893 −54.250 −30.922 1.00 12.81 N ATOM 1934 CA TRP B 402 −63.101 −53.115 −31.323 1.00 14.87 C ATOM 1935 CB TRP B 402 −63.997 −51.863 −31.616 1.00 14.12 C ATOM 1936 CG TRP B 402 −65.021 −52.110 −32.658 1.00 17.28 C ATOM 1937 CD1 TRP B 402 −64.908 −51.878 −34.035 1.00 14.79 C ATOM 1938 NE1 TRP B 402 −66.031 −52.309 −34.686 1.00 19.82 N ATOM 1939 CE2 TRP B 402 −66.914 −52.852 −33.798 1.00 20.82 C ATOM 1940 CD2 TRP B 402 −66.309 −52.755 −32.474 1.00 20.27 C ATOM 1941 CE3 TRP B 402 −67.005 −53.253 −31.369 1.00 20.96 C ATOM 1942 CZ3 TRP B 402 −68.260 −53.808 −31.583 1.00 19.60 C ATOM 1943 CH2 TRP B 402 −68.823 −53.883 −32.863 1.00 21.29 C ATOM 1944 CZ2 TRP B 402 −68.163 −53.404 −33.993 1.00 21.16 C ATOM 1945 C TRP B 402 −62.137 −52.763 −30.206 1.00 13.18 C ATOM 1946 O TRP B 402 −62.463 −52.896 −28.999 1.00 15.35 O ATOM 1947 N LYS B 403 −60.974 −52.288 −30.611 1.00 12.95 N ATOM 1948 CA LYS B 403 −60.040 −51.619 −29.720 1.00 13.69 C ATOM 1949 CB LYS B 403 −58.637 −51.810 −30.221 1.00 16.76 C ATOM 1950 CG LYS B 403 −57.611 −51.355 −29.225 1.00 17.41 C ATOM 1951 CD LYS B 403 −56.218 −51.457 −29.815 1.00 21.23 C ATOM 1952 CE LYS B 403 −55.179 −51.201 −28.718 1.00 30.54 C ATOM 1953 NZ LYS B 403 −53.800 −51.226 −29.288 1.00 28.03 N ATOM 1954 C LYS B 403 −60.348 −50.141 −29.757 1.00 14.38 C ATOM 1955 O LYS B 403 −60.469 −49.547 −30.865 1.00 14.57 O ATOM 1956 N PHE B 404 −60.558 −49.553 −28.574 1.00 13.76 N ATOM 1957 CA PHE B 404 −60.849 −48.112 −28.477 1.00 11.64 C ATOM 1958 CB PHE B 404 −62.092 −47.858 −27.593 1.00 10.58 C ATOM 1959 CG PHE B 404 −63.408 −48.223 −28.255 1.00 9.84 C ATOM 1960 CD1 PHE B 404 −64.081 −47.295 −29.068 1.00 12.16 C ATOM 1961 CE1 PHE B 404 −65.307 −47.621 −29.687 1.00 14.45 C ATOM 1962 CZ PHE B 404 −65.868 −48.887 −29.515 1.00 16.97 C ATOM 1963 CE2 PHE B 404 −65.223 −49.826 −28.701 1.00 10.79 C ATOM 1964 CD2 PHE B 404 −64.003 −49.491 −28.050 1.00 10.33 C ATOM 1965 C PHE B 404 −59.609 −47.394 −27.934 1.00 13.86 C ATOM 1966 O PHE B 404 −59.067 −47.780 −26.881 1.00 13.54 O ATOM 1967 N THR B 405 −59.168 −46.365 −28.651 1.00 14.47 N ATOM 1968 CA THR B 405 −58.007 −45.563 −28.282 1.00 14.84 C ATOM 1969 CB THR B 405 −56.930 −45.655 −29.382 1.00 18.43 C ATOM 1970 OG1 THR B 405 −57.570 −45.517 −30.635 1.00 16.61 O ATOM 1971 CG2 THR B 405 −56.290 −47.077 −29.365 1.00 21.24 C ATOM 1972 C THR B 405 −58.405 −44.102 −28.075 1.00 14.32 C ATOM 1973 O THR B 405 −59.160 −43.520 −28.857 1.00 15.36 O ATOM 1974 N ALA B 406 −57.870 −43.504 −27.035 1.00 15.35 N ATOM 1975 CA ALA B 406 −58.290 −42.180 −26.599 1.00 16.76 C ATOM 1976 CB ALA B 406 −57.716 −41.899 −25.201 1.00 16.59 C ATOM 1977 C ALA B 406 −57.757 −41.169 −27.616 1.00 17.96 C ATOM 1978 O ALA B 406 −56.626 −41.300 −28.084 1.00 18.28 O ATOM 1979 N THR B 407 −58.569 −40.172 −27.968 1.00 20.39 N ATOM 1980 CA THR B 407 −58.090 −39.097 −28.884 1.00 24.31 C ATOM 1981 CB THR B 407 −59.224 −38.512 −29.773 1.00 24.51 C ATOM 1982 OG1 THR B 407 −60.266 −38.018 −28.929 1.00 26.36 O ATOM 1983 CG2 THR B 407 −59.793 −39.589 −30.659 1.00 26.30 C ATOM 1984 C THR B 407 −57.363 −37.959 −28.141 1.00 29.72 C ATOM 1985 O THR B 407 −56.695 −37.166 −28.785 1.00 31.71 O ATOM 1986 N LYS B 408 −57.492 −37.894 −26.804 1.00 26.17 N ATOM 1987 CA LYS B 408 −56.868 −36.817 −25.952 1.00 29.08 C ATOM 1988 CB LYS B 408 −57.945 −35.921 −25.301 1.00 28.98 C ATOM 1989 CG LYS B 408 −58.539 −34.802 −26.139 1.00 41.20 C ATOM 1990 CD LYS B 408 −59.972 −34.533 −25.677 1.00 45.11 C ATOM 1991 CE LYS B 408 −60.332 −33.056 −25.611 1.00 45.63 C ATOM 1992 NZ LYS B 408 −59.736 −32.379 −24.414 1.00 43.58 N ATOM 1993 C LYS B 408 −56.037 −37.470 −24.819 1.00 29.18 C ATOM 1994 O LYS B 408 −56.420 −38.509 −24.297 1.00 19.21 O ATOM 1995 N LYS B 409 −54.944 −36.836 −24.397 1.00 20.60 N ATOM 1996 CA LYS B 409 −54.025 −37.479 −23.439 1.00 24.77 C ATOM 1997 CB LYS B 409 −52.662 −36.745 −23.389 1.00 31.30 C ATOM 1998 CG LYS B 409 −51.836 −36.782 −24.681 1.00 46.02 C ATOM 1999 CD LYS B 409 −51.176 −38.139 −24.923 1.00 49.56 C ATOM 2000 CE LYS B 409 −49.847 −37.975 −25.646 1.00 51.63 C ATOM 2001 NZ LYS B 409 −48.832 −38.962 −25.185 1.00 62.60 N ATOM 2002 C LYS B 409 −54.590 −37.511 −22.023 1.00 21.47 C ATOM 2003 O LYS B 409 −54.129 −38.279 −21.202 1.00 21.08 O ATOM 2004 N ASP B 410 −55.547 −36.640 −21.719 1.00 25.31 N ATOM 2005 CA ASP B 410 −55.948 −36.455 −20.299 1.00 29.10 C ATOM 2006 CB ASP B 410 −56.297 −34.978 −20.028 1.00 33.62 C ATOM 2007 CG ASP B 410 −57.653 −34.577 −20.585 1.00 40.02 C ATOM 2008 OD1 ASP B 410 −58.155 −35.236 −21.536 1.00 47.35 O ATOM 2009 OD2 ASP B 410 −58.233 −33.616 −20.045 1.00 49.30 O ATOM 2010 C ASP B 410 −57.067 −37.442 −19.809 1.00 34.82 C ATOM 2011 O ASP B 410 −57.489 −37.421 −18.626 1.00 35.70 O ATOM 2012 N MET B 411 −57.530 −38.286 −20.739 1.00 26.70 N ATOM 2013 CA MET B 411 −58.584 −39.274 −20.510 1.00 24.05 C ATOM 2014 CB MET B 411 −59.237 −39.654 −21.855 1.00 17.20 C ATOM 2015 CG MET B 411 −60.070 −38.504 −22.378 1.00 34.35 C ATOM 2016 SD MET B 411 −60.976 −38.897 −23.854 1.00 41.84 S ATOM 2017 CE MET B 411 −59.753 −38.728 −25.116 1.00 35.00 C ATOM 2018 C MET B 411 −58.039 −40.535 −19.855 1.00 17.85 C ATOM 2019 O MET B 411 −56.845 −40.853 −19.997 1.00 15.52 O ATOM 2020 N SER B 412 −58.912 −41.278 −19.157 1.00 15.11 N ATOM 2021 CA SER B 412 −58.504 −42.594 −18.652 1.00 15.31 C ATOM 2022 CB SER B 412 −58.084 −42.521 −17.179 1.00 16.71 C ATOM 2023 OG SER B 412 −59.151 −41.959 −16.435 1.00 23.31 O ATOM 2024 C SER B 412 −59.655 −43.563 −18.973 1.00 13.44 C ATOM 2025 O SER B 412 −60.817 −43.204 −18.697 1.00 17.40 O ATOM 2026 N PRO B 413 −59.332 −44.847 −19.117 1.00 10.84 N ATOM 2027 CA PRO B 413 −58.133 −45.357 −19.761 1.00 11.77 C ATOM 2028 CB PRO B 413 −58.413 −46.872 −19.866 1.00 13.65 C ATOM 2029 CG PRO B 413 −59.905 −46.914 −20.137 1.00 12.35 C ATOM 2030 CD PRO B 413 −60.464 −45.793 −19.272 1.00 12.44 C ATOM 2031 C PRO B 413 −57.774 −44.740 −21.092 1.00 12.24 C ATOM 2032 O PRO B 413 −58.648 −44.246 −21.812 1.00 14.30 O ATOM 2033 N GLN B 414 −56.506 −44.747 −21.420 1.00 11.17 N ATOM 2034 CA GLN B 414 −56.120 −44.301 −22.767 1.00 13.27 C ATOM 2035 CB GLN B 414 −54.614 −44.069 −22.841 1.00 15.40 C ATOM 2036 CG GLN B 414 −54.160 −42.747 −22.221 1.00 14.10 C ATOM 2037 CD GLN B 414 −54.693 −41.558 −22.994 1.00 18.35 C ATOM 2038 OE1 GLN B 414 −55.586 −40.819 −22.546 1.00 20.00 O ATOM 2039 NE2 GLN B 414 −54.195 −41.398 −24.161 1.00 12.41 N ATOM 2040 C GLN B 414 −56.527 −45.323 −23.848 1.00 14.48 C ATOM 2041 O GLN B 414 −56.590 −44.995 −25.024 1.00 14.59 O ATOM 2042 N LYS B 415 −56.738 −46.580 −23.460 1.00 14.53 N ATOM 2043 CA LYS B 415 −57.175 −47.611 −24.412 1.00 17.31 C ATOM 2044 CB LYS B 415 −55.987 −48.330 −25.110 1.00 23.52 C ATOM 2045 CG LYS B 415 −55.256 −49.356 −24.243 1.00 40.74 C ATOM 2046 CD LYS B 415 −53.820 −49.626 −24.737 1.00 39.00 C ATOM 2047 CE LYS B 415 −52.897 −50.020 −23.594 1.00 32.11 C ATOM 2048 NZ LYS B 415 −52.701 −48.939 −22.525 1.00 26.56 N ATOM 2049 C LYS B 415 −58.003 −48.599 −23.689 1.00 13.15 C ATOM 2050 O LYS B 415 −57.815 −48.779 −22.501 1.00 10.43 O ATOM 2051 N PHE B 416 −58.932 −49.234 −24.406 1.00 10.99 N ATOM 2052 CA PHE B 416 −59.677 −50.352 −23.876 1.00 10.40 C ATOM 2053 CB PHE B 416 −60.753 −49.882 −22.812 1.00 9.75 C ATOM 2054 CG PHE B 416 −61.895 −49.088 −23.401 1.00 9.21 C ATOM 2055 CD1 PHE B 416 −63.093 −49.739 −23.831 1.00 10.57 C ATOM 2056 CE1 PHE B 416 −64.128 −49.031 −24.430 1.00 10.35 C ATOM 2057 CZ PHE B 416 −64.045 −47.625 −24.564 1.00 12.50 C ATOM 2058 CE2 PHE B 416 −62.885 −46.954 −24.155 1.00 8.92 C ATOM 2059 CD2 PHE B 416 −61.807 −47.683 −23.549 1.00 10.68 C ATOM 2060 C PHE B 416 −60.318 −51.160 −25.050 1.00 12.88 C ATOM 2061 O PHE B 416 −60.111 −50.846 −26.219 1.00 13.90 O ATOM 2062 N TRP B 417 −60.987 −52.261 −24.705 1.00 13.08 N ATOM 2063 CA TRP B 417 −61.687 −53.112 −25.666 1.00 13.85 C ATOM 2064 CB TRP B 417 −61.141 −54.552 −25.639 1.00 13.48 C ATOM 2065 CG TRP B 417 −59.620 −54.608 −25.784 1.00 14.05 C ATOM 2066 CD1 TRP B 417 −58.672 −54.422 −24.788 1.00 13.47 C ATOM 2067 NE1 TRP B 417 −57.423 −54.499 −25.293 1.00 14.55 N ATOM 2068 CE2 TRP B 417 −57.470 −54.750 −26.363 1.00 13.61 C ATOM 2069 CD2 TRP B 417 −58.858 −54.797 −27.012 1.00 12.44 C ATOM 2070 CE3 TRP B 417 −59.206 −55.068 −28.362 1.00 13.69 C ATOM 2071 CZ3 TRP B 417 −58.182 −55.257 −29.273 1.00 19.69 C ATOM 2072 CH2 TRP B 417 −56.832 −55.254 −28.861 1.00 14.18 C ATOM 2073 CZ2 TRP B 417 −56.459 −54.986 −27.532 1.00 12.37 C ATOM 2074 C TRP B 417 −63.180 −53.092 −25.441 1.00 14.18 C ATOM 2075 O TRP B 417 −63.659 −53.217 −24.304 1.00 16.51 O ATOM 2076 N GLY B 418 −63.937 −52.910 −26.523 1.00 16.17 N ATOM 2077 CA GLY B 418 −65.396 −53.083 −26.452 1.00 16.33 C ATOM 2078 C GLY B 418 −65.728 −54.368 −27.187 1.00 20.32 C ATOM 2079 O GLY B 418 −65.492 −54.466 −28.411 1.00 17.26 O ATOM 2080 N LEU B 419 −66.219 −55.366 −26.450 1.00 17.26 N ATOM 2081 CA LEU B 419 −66.427 −56.708 −27.019 1.00 14.96 C ATOM 2082 CB LEU B 419 −65.711 −57.785 −26.140 1.00 14.51 C ATOM 2083 CG LEU B 419 −64.180 −57.669 −25.998 1.00 18.66 C ATOM 2084 CD1 LEU B 419 −63.556 −58.787 −25.169 1.00 18.93 C ATOM 2085 CD2 LEU B 419 −63.451 −57.518 −27.339 1.00 15.37 C ATOM 2086 C LEU B 419 −67.916 −57.024 −27.108 1.00 17.49 C ATOM 2087 O LEU B 419 −68.699 −56.758 −26.168 1.00 21.46 O ATOM 2088 N THR B 420 −68.338 −57.542 −28.254 1.00 17.17 N ATOM 2089 CA THR B 420 −69.732 −58.020 −28.398 1.00 18.52 C ATOM 2090 CB THR B 420 −70.032 −58.310 −29.854 1.00 20.38 C ATOM 2091 OG1 THR B 420 −69.730 −57.117 −30.606 1.00 18.00 O ATOM 2092 CG2 THR B 420 −71.538 −58.737 −30.036 1.00 19.04 C ATOM 2093 C THR B 420 −69.993 −59.249 −27.529 1.00 16.35 C ATOM 2094 O THR B 420 −69.338 −60.271 −27.697 1.00 19.67 O ATOM 2095 N ARG B 421 −70.899 −59.120 −26.548 1.00 16.93 N ATOM 2096 CA ARG B 421 −71.164 −60.206 −25.577 1.00 18.81 C ATOM 2097 CB ARG B 421 −72.268 −59.826 −24.577 1.00 24.60 C ATOM 2098 CG ARG B 421 −71.821 −58.931 −23.437 1.00 30.60 C ATOM 2099 CD ARG B 421 −73.021 −58.413 −22.643 1.00 44.49 C ATOM 2100 NE ARG B 421 −72.679 −57.216 −21.870 1.00 47.25 N ATOM 2101 CZ ARG B 421 −72.379 −57.215 −20.575 1.00 46.85 C ATOM 2102 NH1 ARG B 421 −72.392 −58.349 −19.885 1.00 44.56 N ATOM 2103 NH2 ARG B 421 −72.061 −56.077 −19.972 1.00 47.36 N ATOM 2104 C ARG B 421 −71.609 −61.463 −26.299 1.00 16.85 C ATOM 2105 O ARG B 421 −71.316 −62.546 −25.852 1.00 16.59 O ATOM 2106 N SER B 422 −72.334 −61.299 −27.403 1.00 18.31 N ATOM 2107 CA SER B 422 −72.869 −62.464 −28.121 1.00 18.55 C ATOM 2108 CB SER B 422 −74.081 −62.105 −28.987 1.00 20.38 C ATOM 2109 OG SER B 422 −73.737 −61.243 −30.075 1.00 23.74 O ATOM 2110 C SER B 422 −71.798 −63.189 −28.927 1.00 19.31 C ATOM 2111 O SER B 422 −72.034 −64.284 −29.382 1.00 23.34 O ATOM 2112 N ALA B 423 −70.608 −62.589 −29.060 1.00 16.02 N ATOM 2113 CA ALA B 423 −69.474 −63.220 −29.779 1.00 19.92 C ATOM 2114 CB ALA B 423 −68.702 −62.171 −30.574 1.00 18.55 C ATOM 2115 C ALA B 423 −68.524 −63.995 −28.836 1.00 19.44 C ATOM 2116 O ALA B 423 −67.477 −64.478 −29.266 1.00 17.26 O ATOM 2117 N LEU B 424 −68.909 −64.095 −27.554 1.00 22.12 N ATOM 2118 CA LEU B 424 −68.095 −64.754 −26.491 1.00 23.35 C ATOM 2119 CB LEU B 424 −67.556 −63.704 −25.505 1.00 17.68 C ATOM 2120 CG LEU B 424 −66.679 −62.549 −26.041 1.00 24.01 C ATOM 2121 CD1 LEU B 424 −66.498 −61.410 −25.012 1.00 17.33 C ATOM 2122 CD2 LEU B 424 −65.329 −63.073 −26.519 1.00 23.03 C ATOM 2123 C LEU B 424 −68.896 −65.833 −25.703 1.00 23.59 C ATOM 2124 O LEU B 424 −70.105 −65.704 −25.530 1.00 21.33 O ATOM 2125 N LEU B 425 −68.201 −66.844 −25.186 1.00 25.46 N ATOM 2126 CA LEU B 425 −68.837 −67.906 −24.386 1.00 40.40 C ATOM 2127 CB LEU B 425 −68.614 −69.305 −24.981 1.00 33.88 C ATOM 2128 CG LEU B 425 −69.588 −69.714 −26.127 1.00 37.90 C ATOM 2129 CD1 LEU B 425 −69.444 −71.187 −26.510 1.00 32.69 C ATOM 2130 CD2 LEU B 425 −71.058 −69.369 −25.851 1.00 33.19 C ATOM 2131 C LEU B 425 −68.376 −67.856 −22.942 1.00 41.07 C ATOM 2132 O LEU B 425 −67.202 −67.560 −22.694 1.00 30.97 O ATOM 2133 N PRO B 426 −69.215 −68.395 −22.026 1.00 51.06 N ATOM 2134 CA PRO B 426 −69.893 −67.749 −20.943 1.00 56.21 C ATOM 2135 CB PRO B 426 −68.813 −67.724 −19.855 1.00 55.03 C ATOM 2136 CG PRO B 426 −68.159 −68.089 −20.054 1.00 54.92 C ATOM 2137 CD PRO B 426 −68.569 −69.589 −21.459 1.00 66.24 C ATOM 2138 C PRO B 426 −70.592 −66.396 −21.222 1.00 71.60 C ATOM 2139 O PRO B 426 −70.422 −65.785 −22.294 1.00 54.58 O ATOM 2140 N THR B 427 −71.397 −65.973 −20.242 1.00 89.60 N ATOM 2141 CA THR B 427 −72.420 −64.935 −20.401 1.00 77.65 C ATOM 2142 CB THR B 427 −73.814 −65.586 −20.589 1.00 69.12 C ATOM 2143 OG1 THR B 427 −73.809 −66.395 −21.776 1.00 60.00 O ATOM 2144 CG2 THR B 427 −74.933 −64.530 −20.683 1.00 65.95 C ATOM 2145 C THR B 427 −72.441 −64.012 −19.172 1.00 81.95 C ATOM 2146 O THR B 427 −72.431 −62.783 −19.294 1.00 65.36 O ATOM 2147 N THR C 321 −81.163 −67.769 −55.070 1.00 46.98 N ATOM 2148 CA THR C 321 −80.836 −66.347 −54.733 1.00 42.28 C ATOM 2149 CB THR C 321 −81.543 −65.351 −55.684 1.00 37.36 C ATOM 2150 OG1 THR C 321 −82.953 −65.596 −55.664 1.00 42.28 O ATOM 2151 CG2 THR C 321 −80.998 −65.434 −57.126 1.00 42.25 C ATOM 2152 C THR C 321 −81.211 −65.956 −53.292 1.00 33.29 C ATOM 2153 O THR C 321 −81.079 −64.783 −52.923 1.00 29.40 O ATOM 2154 N SER C 322 −81.683 −66.930 −52.503 1.00 29.39 N ATOM 2155 CA SER C 322 −82.173 −66.709 −51.142 1.00 23.65 C ATOM 2156 CB SER C 322 −82.999 −67.894 −50.681 1.00 25.25 C ATOM 2157 OG SER C 322 −84.127 −68.022 −51.510 1.00 33.84 O ATOM 2158 C SER C 322 −81.080 −66.471 −50.125 1.00 29.14 C ATOM 2159 O SER C 322 −80.048 −67.114 −50.172 1.00 25.03 O ATOM 2160 N LEU C 323 −81.322 −65.544 −49.195 1.00 26.40 N ATOM 2161 CA LEU C 323 −80.403 −65.309 −48.065 1.00 22.98 C ATOM 2162 CB LEU C 323 −79.781 −63.884 −48.103 1.00 18.13 C ATOM 2163 CG LEU C 323 −78.945 −63.489 −49.361 1.00 23.01 C ATOM 2164 CD1 LEU C 323 −78.737 −61.981 −49.492 1.00 17.98 C ATOM 2165 CD2 LEU C 323 −77.588 −64.171 −49.407 1.00 20.81 C ATOM 2166 C LEU C 323 −81.193 −65.563 −46.797 1.00 23.86 C ATOM 2167 O LEU C 323 −82.283 −64.990 −46.595 1.00 18.07 O ATOM 2168 N CYS C 324 −80.666 −66.483 −45.980 1.00 21.54 N ATOM 2169 CA CYS C 324 −81.371 −67.085 −44.862 1.00 20.05 C ATOM 2170 CB CYS C 324 −81.509 −68.631 −45.051 1.00 20.12 C ATOM 2171 SG CYS C 324 −82.543 −69.144 −46.460 1.00 27.33 S ATOM 2172 C CYS C 324 −80.590 −66.791 −43.589 1.00 23.55 C ATOM 2173 O CYS C 324 −79.366 −66.586 −43.617 1.00 18.04 O ATOM 2174 N CYS C 325 −81.310 −66.761 −42.479 1.00 17.94 N ATOM 2175 CA CYS C 325 −80.722 −66.617 −41.151 1.00 20.92 C ATOM 2176 CB CYS C 325 −81.855 −66.707 −40.105 1.00 19.55 C ATOM 2177 SG CYS C 325 −81.339 −66.979 −38.396 1.00 18.34 S ATOM 2178 C CYS C 325 −79.653 −67.721 −40.907 1.00 24.37 C ATOM 2179 O CYS C 325 −79.906 −68.924 −41.117 1.00 19.12 O ATOM 2180 N LYS C 326 −78.443 −67.312 −40.558 1.00 24.15 N ATOM 2181 CA LYS C 326 −77.371 −68.297 −40.405 1.00 26.10 C ATOM 2182 CB LYS C 326 −75.973 −67.662 −40.433 1.00 24.93 C ATOM 2183 CG LYS C 326 −74.836 −68.701 −40.469 1.00 24.58 C ATOM 2184 CD LYS C 326 −73.473 −68.047 −40.514 1.00 26.62 C ATOM 2185 CE LYS C 326 −72.941 −67.813 −39.104 1.00 38.73 C ATOM 2186 NZ LYS C 326 −71.982 −66.675 −39.005 1.00 40.49 N ATOM 2187 C LYS C 326 −77.555 −69.137 −39.123 1.00 29.54 C ATOM 2188 O LYS C 326 −77.177 −70.308 −39.089 1.00 21.61 O ATOM 2189 N GLN C 327 −78.124 −68.519 −38.084 1.00 25.41 N ATOM 2190 CA GLN C 327 −78.401 −69.211 −36.848 1.00 22.49 C ATOM 2191 CB GLN C 327 −78.957 −68.265 −35.806 1.00 24.53 C ATOM 2192 CG GLN C 327 −79.069 −68.951 −34.431 1.00 22.84 C ATOM 2193 CD GLN C 327 −78.801 −68.012 −33.289 1.00 22.97 C ATOM 2194 OE1 GLN C 327 −77.658 −67.811 −32.914 1.00 35.53 O ATOM 2195 NE2 GLN C 327 −79.851 −67.427 −32.732 1.00 16.95 N ATOM 2196 C GLN C 327 −79.329 −70.419 −37.002 1.00 21.89 C ATOM 2197 O GLN C 327 −78.950 −71.540 −36.605 1.00 16.38 O ATOM 2198 N CYS C 328 −80.540 −70.201 −37.549 1.00 14.98 N ATOM 2199 CA CYS C 328 −81.527 −71.273 −37.644 1.00 19.22 C ATOM 2200 CB CYS C 328 −82.887 −70.835 −37.066 1.00 25.65 C ATOM 2201 SG CYS C 328 −83.827 −69.631 −38.049 1.00 21.74 S ATOM 2202 C CYS C 328 −81.715 −71.936 −39.019 1.00 21.58 C ATOM 2203 O CYS C 328 −82.304 −73.017 −39.089 1.00 22.23 O ATOM 2204 N GLN C 329 −81.256 −71.288 −40.096 1.00 20.04 N ATOM 2205 CA GLN C 329 −81.562 −71.723 −41.516 1.00 21.99 C ATOM 2206 CB GLN C 329 −80.689 −72.917 −41.948 1.00 25.27 C ATOM 2207 CG GLN C 329 −79.180 −72.689 −41.918 1.00 30.77 C ATOM 2208 CD GLN C 329 −78.394 −73.954 −42.272 1.00 33.68 C ATOM 2209 OE1 GLN C 329 −78.519 −74.495 −43.375 1.00 30.38 O ATOM 2210 NE2 GLN C 329 −77.592 −74.423 −41.342 1.00 25.06 N ATOM 2211 C GLN C 329 −83.040 −72.023 −41.887 1.00 25.06 C ATOM 2212 O GLN C 329 −83.308 −72.631 −42.910 1.00 27.35 O ATOM 2213 N GLN C 329 −83.990 −71.363 −41.056 1.00 26.36 N ATOM 2214 CA GLU C 330 −85.396 −71.863 −41.359 1.00 24.07 C ATOM 2215 CB GLU C 330 −86.243 −71.703 −40.104 1.00 27.75 C ATOM 2216 CG GLU C 330 −86.080 −72.794 −39.080 1.00 31.44 C ATOM 2217 CD GLU C 330 −87.357 −73.576 −38.881 1.00 45.20 C ATOM 2218 OE1 GLU C 330 −87.653 −74.442 −39.729 1.00 60.72 O ATOM 2219 OE2 GLU C 330 −88.058 −73.332 −37.874 1.00 44.35 O ATOM 2220 C GLU C 330 −85.858 −70.785 −42.291 1.00 26.46 C ATOM 2221 O GLU C 330 −86.682 −71.019 −43.162 1.00 22.85 O ATOM 2222 N THR C 331 −85.350 −69.586 −42.061 1.00 22.12 N ATOM 2223 CA THR C 331 −86.007 −68.375 −42.536 1.00 27.33 C ATOM 2224 CB THR C 331 −86.116 −67.374 −41.382 1.00 27.69 C ATOM 2225 OG1 THR C 331 −85.152 −67.723 −40.378 1.00 46.96 O ATOM 2226 CG2 THR C 331 −87.506 −67.428 −40.774 1.00 28.75 C ATOM 2227 C THR C 331 −85.263 −67.697 −43.666 1.00 21.21 C ATOM 2228 O THR C 331 −84.121 −67.316 −43.491 1.00 25.87 O ATOM 2229 N GLU C 332 −85.922 −67.503 −44.810 1.00 23.34 N ATOM 2230 CA GLU C 332 −85.435 −66.548 −45.818 1.00 21.62 C ATOM 2231 CB GLU C 332 −86.175 −66.705 −47.149 1.00 29.24 C ATOM 2232 CG GLU C 332 −85.475 −66.033 −48.320 1.00 22.09 C ATOM 2233 CD GLU C 332 −86.297 −66.037 −49.572 1.00 24.57 C ATOM 2234 OE1 GLU C 332 −86.188 −66.985 −50.373 1.00 20.93 O ATOM 2235 OE2 GLU C 332 −87.081 −65.085 −49.757 1.00 22.95 O ATOM 2236 C GLU C 332 −85.610 −65.106 −45.287 1.00 20.74 C ATOM 2237 O GLU C 332 −86.700 −64.744 −44.845 1.00 19.53 O ATOM 2238 N ILE C 333 −84.529 −64.322 −45.297 1.00 17.32 N ATOM 2239 CA ILE C 333 −84.564 −62.924 −44.780 1.00 19.51 C ATOM 2240 CB ILE C 333 −83.338 −62.623 −43.841 1.00 16.82 C ATOM 2241 CG1 ILE C 333 −83.321 −63.521 −42.593 1.00 19.39 C ATOM 2242 CD1 ILE C 333 −84.625 −63.569 −41.794 1.00 15.23 C ATOM 2243 CG2 ILE C 333 −83.303 −61.181 −43.364 1.00 15.68 C ATOM 2244 C ILE C 333 −84.641 −61.931 −45.960 1.00 19.54 C ATOM 2245 O ILE C 333 −85.355 −60.913 −45.907 1.00 21.47 O ATOM 2246 N THR C 334 −83.940 −62.252 −47.039 1.00 17.14 N ATOM 2247 CA THR C 334 −83.993 −61.440 −48.237 1.00 23.08 C ATOM 2248 CB THR C 334 −83.208 −60.117 −48.052 1.00 22.90 C ATOM 2249 OG1 THR C 334 −83.578 −59.189 −49.103 1.00 21.85 O ATOM 2250 CG2 THR C 334 −81.722 −60.385 −48.052 1.00 16.89 C ATOM 2251 C THR C 334 −83.513 −62.257 −49.462 1.00 26.72 C ATOM 2252 O THR C 334 −83.274 −63.456 −49.348 1.00 23.46 O ATOM 2253 N THR C 335 −83.436 −61.627 −50.632 1.00 20.32 N ATOM 2254 CA THR C 335 −82.870 −62.287 −51.805 1.00 22.95 C ATOM 2255 CB THR C 335 −83.965 −62.677 −52.828 1.00 17.83 C ATOM 2256 OG1 THR C 335 −84.351 −61.523 −53.575 1.00 18.96 O ATOM 2257 CG2 THR C 335 −85.189 −63.250 −52.125 1.00 22.92 C ATOM 2258 C THR C 335 −81.861 −61.351 −52.478 1.00 20.83 C ATOM 2259 O THR C 335 −81.930 −60.142 −52.293 1.00 25.75 O ATOM 2260 N LYS C 336 −80.951 −61.896 −53.272 1.00 21.32 N ATOM 2261 CA LYS C 336 −79.993 −61.067 −54.003 1.00 20.05 C ATOM 2262 CB LYS C 336 −79.017 −61.916 −54.830 1.00 20.79 C ATOM 2263 CG LYS C 336 −78.329 −63.030 −54.057 1.00 32.46 C ATOM 2264 CD LYS C 336 −77.133 −63.556 −54.839 1.00 29.11 C ATOM 2265 CE LYS C 336 −76.706 −64.932 −54.347 1.00 36.46 C ATOM 2266 NZ LYS C 336 −75.465 −65.353 −55.056 1.00 30.66 N ATOM 2267 C LYS C 336 −80.661 −60.048 −54.918 1.00 21.28 C ATOM 2268 O LYS C 336 −80.046 −59.062 −55.261 1.00 21.73 O ATOM 2269 N ASN C 337 −81.916 −60.295 −55.321 1.00 21.93 N ATOM 2270 CA ASN C 337 −82.666 −59.342 −56.141 1.00 21.42 C ATOM 2271 CB ASN C 337 −83.996 −59.956 −56.574 1.00 22.86 C ATOM 2272 CG ASN C 337 −83.798 −61.137 −57.482 1.00 32.77 C ATOM 2273 OD1 ASN C 337 −84.306 −62.233 −57.230 1.00 32.91 O ATOM 2274 ND2 ASN C 337 −83.010 −60.933 −58.528 1.00 28.14 N ATOM 2275 C ASN C 337 −82.921 −58.012 −55.468 1.00 20.11 C ATOM 2276 O ASN C 337 −83.025 −56.991 −56.118 1.00 25.16 O ATOM 2277 N GLU C 338 −82.996 −58.032 −54.151 1.00 23.05 N ATOM 2278 CA GLU C 338 −83.342 −56.850 −53.383 1.00 20.08 C ATOM 2279 CB GLU C 338 −84.132 −57.246 −52.126 1.00 19.55 C ATOM 2280 CG GLU C 338 −85.419 −58.008 −52.395 1.00 21.56 C ATOM 2281 CD GLU C 338 −86.372 −57.270 −53.317 1.00 20.95 C ATOM 2282 OE1 GLU C 338 −86.465 −56.039 −53.249 1.00 21.12 O ATOM 2283 OE2 GLU C 338 −87.036 −57.929 −54.121 1.00 33.16 O ATOM 2284 C GLU C 338 −82.148 −55.956 −53.053 1.00 21.96 C ATOM 2285 O GLU C 338 −82.324 −54.841 −52.549 1.00 18.35 O ATOM 2286 N ILE C 339 −80.935 −56.437 −53.348 1.00 20.77 N ATOM 2287 CA ILE C 339 −79.720 −55.693 −53.020 1.00 22.43 C ATOM 2288 CB ILE C 339 −78.451 −56.537 −53.343 1.00 24.21 C ATOM 2289 CG1 ILE C 339 −78.423 −57.817 −52.492 1.00 19.19 C ATOM 2290 CD1 ILE C 339 −77.307 −58.792 −52.904 1.00 23.39 C ATOM 2291 CG2 ILE C 339 −77.180 −55.693 −53.208 1.00 22.16 C ATOM 2292 C ILE C 339 −79.645 −54.411 −53.806 1.00 17.81 C ATOM 2293 O ILE C 339 −79.860 −54.399 −55.028 1.00 18.79 O ATOM 2294 N PHE C 340 −79.341 −53.320 −53.118 1.00 16.84 N ATOM 2295 CA PHE C 340 −78.978 −52.075 −53.797 1.00 16.78 C ATOM 2296 CB PHE C 340 −80.213 −51.114 −53.964 1.00 18.21 C ATOM 2297 CG PHE C 340 −80.638 −50.460 −52.676 1.00 14.94 C ATOM 2298 CD1 PHE C 340 −80.350 −49.117 −52.437 1.00 13.68 C ATOM 2299 CE1 PHE C 340 −80.678 −48.532 −51.219 1.00 14.56 C ATOM 2300 CZ PHE C 340 −81.254 −49.299 −50.210 1.00 10.73 C ATOM 2301 CE2 PHE C 340 −81.535 −50.617 −50.437 1.00 17.87 C ATOM 2302 CD2 PHE C 340 −81.196 −51.210 −51.665 1.00 16.15 C ATOM 2303 C PHE C 340 −77.861 −51.435 −52.979 1.00 19.88 C ATOM 2304 O PHE C 340 −77.474 −51.947 −51.907 1.00 21.42 O ATOM 2305 N SER C 341 −77.309 −50.346 −53.479 1.00 22.94 N ATOM 2306 CA SER C 341 −76.117 −49.775 −52.854 1.00 24.27 C ATOM 2307 CB SER C 341 −74.885 −49.980 −53.741 1.00 30.70 C ATOM 2308 OG SER C 341 −73.724 −49.384 −53.163 1.00 29.81 O ATOM 2309 C SER C 341 −76.339 −48.299 −52.632 1.00 21.45 C ATOM 2310 O SER C 341 −76.660 −47.582 −53.578 1.00 20.90 O ATOM 2311 N LEU C 342 −76.218 −47.876 −51.370 1.00 20.39 N ATOM 2312 CA LEU C 342 −76.174 −46.450 −50.978 1.00 23.25 C ATOM 2313 CB LEU C 342 −76.891 −46.225 −49.640 1.00 20.02 C ATOM 2314 CG LEU C 342 −78.415 −46.143 −49.587 1.00 22.57 C ATOM 2315 CD1 LEU C 342 −78.901 −45.641 −48.231 1.00 28.56 C ATOM 2316 CD2 LEU C 342 −78.911 −45.217 −50.711 1.00 23.97 C ATOM 2317 C LEU C 342 −74.739 −45.834 −50.905 1.00 22.83 C ATOM 2318 O LEU C 342 −74.587 −44.691 −50.491 1.00 23.02 O ATOM 2319 N SER C 343 −73.706 −46.574 −51.299 1.00 24.57 N ATOM 2320 CA SER C 343 −72.330 −46.033 −51.163 1.00 32.35 C ATOM 2321 CB SER C 343 −71.375 −47.099 −50.636 1.00 30.10 C ATOM 2322 OG SER C 343 −71.230 −48.126 −51.571 1.00 30.70 O ATOM 2323 C SER C 343 −71.773 −45.365 −52.440 1.00 33.73 C ATOM 2324 O SER C 343 −72.296 −45.571 −53.547 1.00 27.11 O ATOM 2325 N GLU C 360 −69.602 −55.743 −45.543 1.00 52.55 N ATOM 2326 CA GLU C 360 −69.920 −55.803 −44.113 1.00 54.23 C ATOM 2327 CB GLU C 360 −69.177 −54.686 −43.358 1.00 54.41 C ATOM 2328 CG GLU C 360 −69.204 −54.811 −41.839 1.00 65.60 C ATOM 2329 CD GLU C 360 −68.200 −55.822 −41.307 1.00 77.62 C ATOM 2330 OE1 GLU C 360 −68.633 −56.918 −40.884 1.00 91.65 O ATOM 2331 OE2 GLU C 360 −66.981 −55.526 −41.312 1.00 73.51 O ATOM 2332 C GLU C 360 −71.438 −55.701 −43.877 1.00 51.43 C ATOM 2333 O GLU C 360 −72.052 −56.602 −43.228 1.00 31.76 O ATOM 2334 N THR C 361 −72.014 −54.598 −44.389 1.00 35.39 N ATOM 2335 CA THR C 361 −73.442 −54.297 −44.272 1.00 38.84 C ATOM 2336 CB THR C 361 −73.726 −52.967 −43.519 1.00 40.66 C ATOM 2337 OG1 THR C 361 −73.217 −53.056 −42.188 1.00 42.81 O ATOM 2338 CG2 THR C 361 −75.243 −52.698 −43.429 1.00 34.48 C ATOM 2339 C THR C 361 −74.103 −54.290 −45.648 1.00 30.09 C ATOM 2340 O THR C 361 −73.856 −53.444 −46.473 1.00 32.36 O ATOM 2341 N LEU C 362 −74.936 −55.289 −45.853 1.00 25.52 N ATOM 2342 CA LEU C 362 −75.671 −55.498 −47.044 1.00 22.31 C ATOM 2343 CB LEU C 362 −76.041 −56.965 −47.088 1.00 18.41 C ATOM 2344 CG LEU C 362 −76.738 −57.429 −48.347 1.00 24.88 C ATOM 2345 CD1 LEU C 362 −75.722 −57.567 −49.465 1.00 23.94 C ATOM 2346 CD2 LEU C 362 −77.410 −58.755 −48.068 1.00 26.77 C ATOM 2347 C LEU C 362 −76.946 −54.638 −46.974 1.00 23.71 C ATOM 2348 O LEU C 362 −77.624 −54.621 −54.960 1.00 20.35 O ATOM 2349 N THR C 363 −77.244 −53.893 −48.022 1.00 22.76 N ATOM 2350 CA THR C 363 −78.470 −53.075 −47.999 1.00 21.61 C ATOM 2351 CB THR C 363 −78.211 −51.560 −48.165 1.00 19.73 C ATOM 2352 OG1 THR C 363 −77.405 −51.336 −49.320 1.00 19.98 O ATOM 2353 CG2 THR C 363 −77.502 −50.979 −46.955 1.00 23.36 C ATOM 2354 C THR C 363 −79.465 −53.564 −49.043 1.00 20.00 C ATOM 2355 O THR C 363 −79.127 −53.722 −50.232 1.00 20.90 O ATOM 2356 N VAL C 364 −80.677 −53.836 −48.579 1.00 17.53 N ATOM 2357 CA VAL C 364 −81.724 −54.363 −49.431 1.00 14.26 C ATOM 2358 CB VAL C 364 −82.019 −55.877 −49.167 1.00 15.57 C ATOM 2359 CG1 VAL C 364 −80.830 −56.741 −49.572 1.00 13.04 C ATOM 2360 CG2 VAL C 364 −82.479 −56.132 −47.725 1.00 13.21 C ATOM 2361 C VAL C 364 −83.029 −53.560 −49.307 1.00 15.93 C ATOM 2362 O VAL C 364 −83.374 −53.021 −48.222 1.00 13.02 O ATOM 2363 N TYR C 365 −83.780 −53.496 −50.422 1.00 14.42 N ATOM 2364 CA TYR C 365 −85.057 −52.749 −50.434 1.00 13.84 C ATOM 2365 CB TYR C 365 −85.570 −52.636 −51.891 1.00 13.70 C ATOM 2366 CG TYR C 365 −84.847 −51.572 −52.738 1.00 13.42 C ATOM 2367 CD1 TYR C 365 −84.859 −50.240 −52.343 1.00 13.91 C ATOM 2368 CE1 TYR C 365 −84.253 −49.252 −53.104 1.00 16.10 C ATOM 2369 CZ TYR C 365 −83.591 −49.599 −54.254 1.00 17.40 C ATOM 2370 OH TYR C 365 −83.001 −48.595 −54.952 1.00 19.12 O ATOM 2371 CE2 TYR C 365 −83.569 −50.915 −54.704 1.00 17.41 C ATOM 2372 CD2 TYR C 365 −84.187 −51.904 −53.932 1.00 15.14 C ATOM 2373 C TYR C 365 −86.144 −53.414 −49.577 1.00 15.35 C ATOM 2374 O TYR C 365 −87.091 −52.748 −49.088 1.00 13.64 O ATOM 2375 N LYS C 366 −86.073 −54.745 −49.541 1.00 14.25 N ATOM 2376 CA LYS C 366 −87.127 −55.597 −49.043 1.00 14.23 C ATOM 2377 CB LYS C 366 −87.974 −56.154 −50.210 1.00 12.69 C ATOM 2378 CG LYS C 366 −88.869 −55.089 −50.842 1.00 16.11 C ATOM 2379 CD LYS C 366 −90.141 −54.986 −50.014 1.00 19.06 C ATOM 2380 CE LYS C 366 −90.783 −53.645 −50.166 1.00 21.60 C ATOM 2381 NZ LYS C 366 −92.145 −53.618 −49.494 1.00 18.72 N ATOM 2382 C LYS C 366 −86.517 −56.747 −48.278 1.00 14.08 C ATOM 2383 O LYS C 366 −85.521 −57.306 −48.704 1.00 16.75 O ATOM 2384 N ALA C 367 −87.166 −57.118 −47.174 1.00 14.13 N ATOM 2385 CA ALA C 367 −86.789 −58.295 −46.373 1.00 19.06 C ATOM 2386 CB ALA C 367 −85.816 −57.902 −45.270 1.00 23.22 C ATOM 2387 C ALA C 367 −88.052 −58.931 −45.782 1.00 15.78 C ATOM 2388 O ALA C 367 −89.171 −58.371 −45.893 1.00 16.35 O ATOM 2389 N SER C 368 −87.883 −60.082 −45.139 1.00 25.21 N ATOM 2390 CA SER C 368 −89.003 −60.861 −44.644 1.00 16.87 C ATOM 2391 CB SER C 368 −89.459 −61.801 −45.748 1.00 20.22 C ATOM 2392 OG SER C 368 −88.378 −62.647 −46.127 1.00 21.26 O ATOM 2393 C SER C 368 −88.627 −61.659 −43.412 1.00 18.86 C ATOM 2394 O SER C 368 −87.450 −61.900 −43.159 1.00 17.15 O ATOM 2395 N ASN C 369 −89.628 −62.071 −42.632 1.00 20.30 N ATOM 2396 CA ASN C 369 −89.397 −62.937 −41.486 1.00 18.43 C ATOM 2397 CB ASN C 369 −88.708 −64.237 −41.918 1.00 16.49 C ATOM 2398 CG ASN C 369 −89.627 −65.182 −42.652 1.00 23.70 C ATOM 2399 OD1 ASN C 369 −89.246 −65.762 −43.671 1.00 31.98 O ATOM 2400 ND2 ASN C 369 −90.816 −65.372 −42.136 1.00 20.80 N ATOM 2401 C ASN C 369 −88.515 −62.242 −40.421 1.00 25.29 C ATOM 2402 O ASN C 369 −87.869 −62.905 −39.616 1.00 23.47 O ATOM 2403 N LEU C 370 −88.496 −60.919 −40.417 1.00 23.30 N ATOM 2404 CA LEU C 370 −87.835 −60.186 −39.339 1.00 20.41 C ATOM 2405 CB LEU C 370 −86.930 −59.096 −39.922 1.00 20.05 C ATOM 2406 CG LEU C 370 −85.600 −59.478 −40.564 1.00 21.32 C ATOM 2407 CD1 LEU C 370 −84.956 −58.253 −41.231 1.00 21.83 C ATOM 2408 CD2 LEU C 370 −84.703 −59.997 −39.469 1.00 19.90 C ATOM 2409 C LEU C 370 −88.866 −59.545 −38.414 1.00 19.73 C ATOM 2410 O LEU C 370 −89.894 −59.044 −38.859 1.00 16.55 O ATOM 2411 N ASN C 371 −88.578 −59.587 −37.111 1.00 21.86 N ATOM 2412 CA ASN C 371 −89.297 −58.817 −36.086 1.00 20.75 C ATOM 2413 CB ASN C 371 −89.453 −59.650 −34.786 1.00 27.32 C ATOM 2414 CG ASN C 371 −90.630 −60.615 −34.835 1.00 27.97 C ATOM 2415 OD1 ASN C 371 −90.525 −61.755 −34.385 1.00 33.05 O ATOM 2416 ND2 ASN C 371 −91.743 −60.168 −35.380 1.00 30.46 N ATOM 2417 C ASN C 371 −88.532 −57.563 −35.704 1.00 22.41 C ATOM 2418 O ASN C 371 −87.308 −57.611 −35.490 1.00 20.00 O ATOM 2419 N LEU C 372 −89.270 −56.479 −35.536 1.00 22.71 N ATOM 2420 CA LEU C 372 −88.691 −55.189 −35.185 1.00 22.26 C ATOM 2421 CB LEU C 372 −89.479 −54.047 −35.861 1.00 22.35 C ATOM 2422 CG LEU C 372 −89.420 −54.049 −37.410 1.00 26.74 C ATOM 2423 CD1 LEU C 372 −90.387 −53.036 −38.002 1.00 27.24 C ATOM 2424 CD2 LEU C 372 −87.984 −53.851 −37.940 1.00 21.45 C ATOM 2425 C LEU C 372 −88.709 −55.053 −33.678 1.00 25.61 C ATOM 2426 O LEU C 372 −89.715 −55.368 −33.041 1.00 26.85 O ATOM 2427 N ILE C 373 −87.588 −54.599 −33.108 1.00 27.10 N ATOM 2428 CA ILE C 373 −87.426 −54.479 −31.651 1.00 32.55 C ATOM 2429 CB ILE C 373 −86.147 −55.223 −31.152 1.00 29.41 C ATOM 2430 CG1 ILE C 373 −86.133 −56.670 −31.639 1.00 32.76 C ATOM 2431 CD1 ILE C 373 −87.284 −57.505 −31.127 1.00 35.55 C ATOM 2432 CG2 ILE C 373 −86.042 −55.185 −29.628 1.00 27.88 C ATOM 2433 C ILE C 373 −87.293 −53.020 −31.255 1.00 33.85 C ATOM 2434 O ILE C 373 −86.313 −52.386 −31.615 1.00 35.67 O ATOM 2435 N GLY C 374 −88.255 −52.504 −30.490 1.00 30.51 N ATOM 2436 CA GLY C 374 −88.189 −51.127 −29.994 1.00 27.83 C ATOM 2437 C GLY C 374 −88.641 −50.100 −31.028 1.00 36.00 C ATOM 2438 O GLY C 374 −89.362 −50.430 −32.003 1.00 33.60 O ATOM 2439 N ARG C 375 −88.222 −48.855 −30.828 1.00 29.88 N ATOM 2440 CA ARG C 375 −88.601 −47.757 −31.729 1.00 41.32 C ATOM 2441 CB ARG C 375 −89.312 −46.624 −30.957 1.00 47.07 C ATOM 2442 CG ARG C 375 −90.166 −47.051 −29.762 1.00 56.68 C ATOM 2443 CD ARG C 375 −90.523 −45.851 −28.878 1.00 64.81 C ATOM 2444 NE ARG C 375 −89.341 −45.063 −28.502 1.00 67.63 N ATOM 2445 CZ ARG C 375 −88.776 −45.061 −27.296 1.00 64.13 C ATOM 2446 NH1 ARG C 375 −89.289 −45.791 −26.312 1.00 69.74 N ATOM 2447 NH2 ARG C 375 −87.699 −44.316 −27.069 1.00 57.83 N ATOM 2448 C ARG C 375 −87.364 −47.180 −32.445 1.00 34.00 C ATOM 2449 O ARG C 375 −86.248 −47.274 −31.928 1.00 33.86 O ATOM 2450 N PRO C 376 −87.575 −46.543 −33.611 1.00 32.65 N ATOM 2451 CA PRO C 376 −86.536 −45.888 −34.385 1.00 27.25 C ATOM 2452 CB PRO C 376 −87.331 −45.036 −35.348 1.00 26.79 C ATOM 2453 CG PRO C 376 −88.530 −45.865 −35.632 1.00 27.98 C ATOM 2454 CD PRO C 376 −88.852 −46.576 −34.352 1.00 29.06 C ATOM 2455 C PRO C 376 −85.641 −44.993 −33.567 1.00 24.98 C ATOM 2456 O PRO C 376 −86.117 −44.268 −32.698 1.00 24.04 O ATOM 2457 N SER C 377 −84.346 −45.034 −33.867 1.00 20.29 N ATOM 2458 CA SER C 377 −83.385 −44.058 −33.324 1.00 17.43 C ATOM 2459 CB SER C 377 −82.593 −44.726 −32.188 1.00 19.24 C ATOM 2460 OG SER C 377 −81.515 −43.906 −31.790 1.00 20.33 O ATOM 2461 C SER C 377 −82.400 −43.579 −34.426 1.00 16.89 C ATOM 2462 O SER C 377 −82.010 −44.365 −35.287 1.00 17.47 O ATOM 2463 N THR C 378 −81.986 −42.314 −34.370 1.00 13.71 N ATOM 2464 CA THR C 378 −80.940 −41.763 −35.234 1.00 14.26 C ATOM 2465 CB THR C 378 −81.258 −40.312 −35.651 1.00 15.80 C ATOM 2466 OG1 THR C 378 −81.414 −39.538 −34.469 1.00 16.41 O ATOM 2467 CG2 THR C 378 −82.560 −40.244 −36.431 1.00 15.94 C ATOM 2468 C THR C 378 −79.568 −41.750 −34.508 1.00 16.21 C ATOM 2469 O THR C 378 −78.565 −41.337 −35.082 1.00 14.59 O ATOM 2470 N VAL C 379 −79.514 −42.267 −33.273 1.00 17.42 N ATOM 2471 CA VAL C 379 −78.262 −42.231 −32.513 1.00 17.78 C ATOM 2472 CB VAL C 379 −78.462 −42.728 −31.058 1.00 21.09 C ATOM 2473 CG1 VAL C 379 −77.131 −43.110 −30.429 1.00 22.33 C ATOM 2474 CG2 VAL C 379 −79.161 −41.659 −30.203 1.00 22.27 C ATOM 2475 C VAL C 379 −77.197 −43.073 −33.242 1.00 17.74 C ATOM 2476 O VAL C 379 −77.437 −44.244 −33.558 1.00 20.55 O ATOM 2477 N HIS C 380 −76.074 −42.444 −33.580 1.00 15.18 N ATOM 2478 CA HIS C 380 −74.972 −43.091 −34.313 1.00 16.42 C ATOM 2479 CB HIS C 380 −74.261 −44.132 −33.439 1.00 14.16 C ATOM 2480 CG HIS C 380 −73.736 −43.572 −32.141 1.00 14.82 C ATOM 2481 ND1 HIS C 380 −72.964 −42.466 −32.091 1.00 15.11 N ATOM 2482 CE1 HIS C 380 −72.646 −42.207 −30.825 1.00 14.35 C ATOM 2483 NE2 HIS C 380 −73.224 −43.142 −30.052 1.00 14.28 N ATOM 2484 CD2 HIS C 380 −73.893 −44.000 −30.832 1.00 13.71 C ATOM 2485 C HIS C 380 −75.375 −43.713 −35.640 1.00 16.83 C ATOM 2486 O HIS C 380 −74.740 −44.647 −36.111 1.00 16.57 O ATOM 2487 N SER C 381 −76.419 −43.195 −36.269 1.00 18.32 N ATOM 2488 CA SER C 381 −76.891 −43.794 −37.495 1.00 16.78 C ATOM 2489 CB SER C 381 −78.035 −42.978 −38.085 1.00 18.69 C ATOM 2490 OG SER C 381 −78.510 −43.648 −39.237 1.00 18.08 O ATOM 2491 C SER C 381 −75.783 −43.953 −38.565 1.00 15.20 C ATOM 2492 O SER C 381 −75.097 −42.971 −38.932 1.00 15.38 O ATOM 2493 N TRP C 382 −75.651 −45.168 −39.099 1.00 12.21 N ATOM 2494 CA TRP C 382 −74.695 −45.412 −40.183 1.00 15.15 C ATOM 2495 CB TRP C 382 −74.434 −46.905 −40.339 1.00 16.24 C ATOM 2496 CG TRP C 382 −73.870 −47.552 −39.118 1.00 17.49 C ATOM 2497 CD1 TRP C 382 −73.011 −46.985 −38.162 1.00 19.24 C ATOM 2498 NE1 TRP C 382 −72.714 −47.892 −37.196 1.00 20.42 N ATOM 2499 CE2 TRP C 382 −73.332 −49.067 −37.431 1.00 21.54 C ATOM 2500 CD2 TRP C 382 −74.068 −48.926 −38.676 1.00 19.62 C ATOM 2501 CE3 TRP C 382 −74.809 −50.009 −39.151 1.00 22.96 C ATOM 2502 CZ3 TRP C 382 −74.783 −51.204 −38.417 1.00 22.86 C ATOM 2503 CH2 TRP C 382 −74.027 −51.329 −37.241 1.00 29.27 C ATOM 2504 CZ2 TRP C 382 −73.296 −50.264 −36.723 1.00 23.34 C ATOM 2505 C TRP C 382 −75.121 −44.800 −41.523 1.00 17.69 C ATOM 2506 O TRP C 382 −74.291 −44.653 −42.439 1.00 21.22 O ATOM 2507 N PHE C 383 −76.388 −44.406 −41.642 1.00 15.13 N ATOM 2508 CA PHE C 383 −76.892 −43.767 −42.891 1.00 17.40 C ATOM 2509 CB PHE C 383 −77.830 −44.722 −43.645 1.00 15.15 C ATOM 2510 CG PHE C 383 −77.191 −46.004 −44.044 1.00 15.57 C ATOM 2511 CD1 PHE C 383 −76.392 −46.065 −45.194 1.00 17.30 C ATOM 2512 CE1 PHE C 383 −75.772 −47.244 −45.554 1.00 18.74 C ATOM 2513 CZ PHE C 383 −75.935 −48.373 −44.768 1.00 22.69 C ATOM 2514 CE2 PHE C 383 −76.713 −48.322 −43.612 1.00 16.16 C ATOM 2515 CD2 PHE C 383 −77.320 −47.140 −43.245 1.00 14.21 C ATOM 2516 C PHE C 383 −77.584 −42.437 −42.593 1.00 16.90 C ATOM 2517 O PHE C 383 −78.775 −42.409 −42.226 1.00 19.70 O ATOM 2518 N PRO C 384 −76.833 −41.323 −42.694 1.00 19.16 N ATOM 2519 CA PRO C 384 −77.364 −40.000 −42.343 1.00 21.35 C ATOM 2520 CB PRO C 384 −76.280 −39.043 −42.863 1.00 25.42 C ATOM 2521 CG PRO C 384 −75.025 −39.831 −42.729 1.00 24.79 C ATOM 2522 CD PRO C 384 −75.386 −41.279 −42.975 1.00 19.81 C ATOM 2523 C PRO C 384 −78.704 −39.724 −43.020 1.00 24.37 C ATOM 2524 O PRO C 384 −78.862 −40.020 −44.209 1.00 27.93 O ATOM 2525 N GLY C 385 −79.669 −39.215 −42.246 1.00 22.67 N ATOM 2526 CA GLY C 385 −81.032 −39.029 −42.713 1.00 24.78 C ATOM 2527 C GLY C 385 −81.988 −40.192 −42.400 1.00 21.92 C ATOM 2528 O GLY C 385 −83.167 −40.063 −42.584 1.00 24.00 O ATOM 2529 N TYR C 386 −81.471 −41.323 −41.927 1.00 16.94 N ATOM 2530 CA TYR C 386 −82.298 −42.461 −41.564 1.00 16.82 C ATOM 2531 CB TYR C 386 −81.820 −43.717 −42.327 1.00 14.65 C ATOM 2532 CG TYR C 386 −82.097 −43.646 −43.829 1.00 16.35 C ATOM 2533 CD1 TYR C 386 −83.316 −44.111 −44.353 1.00 17.04 C ATOM 2534 CE1 TYR C 386 −83.604 −44.008 −45.731 1.00 16.61 C ATOM 2535 CZ TYR C 386 −82.650 −43.497 −46.590 1.00 16.13 C ATOM 2536 OH TYR C 386 −82.933 −43.447 −47.940 1.00 19.45 O ATOM 2537 CE2 TYR C 386 −81.432 −43.014 −46.095 1.00 16.85 C ATOM 2538 CD2 TYR C 386 −81.153 −43.106 −44.721 1.00 15.17 C ATOM 2539 C TYR C 386 −82.193 −42.743 −40.068 1.00 19.03 C ATOM 2540 O TYR C 386 −81.150 −42.510 −39.478 1.00 15.89 O ATOM 2541 N ALA C 387 −83.276 −43.269 −39.484 1.00 17.66 N ATOM 2542 CA ALA C 387 −83.258 −43.803 −38.134 1.00 18.44 C ATOM 2543 CB ALA C 387 −84.507 −43.353 −37.400 1.00 19.84 C ATOM 2544 C ALA C 387 −83.185 −45.341 −38.208 1.00 17.79 C ATOM 2545 O ALA C 387 −83.553 −45.907 −39.210 1.00 20.57 O ATOM 2546 N TRP C 388 −82.703 −46.017 −37.161 1.00 14.28 N ATOM 2547 CA TRP C 388 −82.644 −47.497 −37.185 1.00 17.54 C ATOM 2548 CB TRP C 388 −81.205 −47.982 −37.011 1.00 17.30 C ATOM 2549 CG TRP C 388 −80.515 −47.438 −35.790 1.00 17.52 C ATOM 2550 CD1 TRP C 388 −79.680 −46.319 −35.714 1.00 17.47 C ATOM 2551 NE1 TRP C 388 −79.220 −46.146 −34.423 1.00 20.00 N ATOM 2552 CE2 TRP C 388 −79.725 −47.096 −33.598 1.00 21.83 C ATOM 2553 CD2 TRP C 388 −80.566 −47.976 −34.419 1.00 19.49 C ATOM 2554 CE3 TRP C 388 −81.214 −49.052 −33.811 1.00 20.29 C ATOM 2555 CZ3 TRP C 388 −81.002 −49.274 −32.420 1.00 22.79 C ATOM 2556 CH2 TRP C 388 −80.204 −48.405 −31.651 1.00 23.47 C ATOM 2557 CZ2 TRP C 388 −79.531 −47.317 −32.228 1.00 21.03 C ATOM 2558 C TRP C 388 −83.534 −48.170 −36.155 1.00 20.00 C ATOM 2559 O TRP C 388 −83.771 −47.624 −35.097 1.00 21.86 O ATOM 2560 N THR C 389 −84.023 −49.370 −36.478 1.00 22.70 N ATOM 2561 CA THR C 389 −84.696 −50.244 −35.510 1.00 17.72 C ATOM 2562 CB THR C 389 −86.216 −50.337 −35.823 1.00 21.51 C ATOM 2563 OG1 THR C 389 −86.741 −49.025 −35.994 1.00 21.64 O ATOM 2564 CG2 THR C 389 −86.978 −51.002 −34.645 1.00 21.45 C ATOM 2565 C THR C 389 84.111 −51.648 −35.617 1.00 21.06 C ATOM 2566 O THR C 389 −84.000 −52.175 −36.712 1.00 21.49 O ATOM 2567 N ILE C 390 −83.702 −52.245 −34.480 1.00 17.91 N ATOM 2568 CA ILE C 390 −83.173 −53.598 −34.486 1.00 15.81 C ATOM 2569 CB ILE C 390 −82.809 −54.079 −33.075 1.00 16.95 C ATOM 2570 CG1 ILE C 390 −81.583 −53.312 −32.571 1.00 18.71 C ATOM 2571 CD1 ILE C 390 −81.213 −53.618 −31.126 1.00 22.31 C ATOM 2572 CG2 ILE C 390 −82.523 −55.583 −33.082 1.00 21.05 C ATOM 2573 C ILE C 390 −84.182 −54.543 −35.104 1.00 18.48 C ATOM 2574 O ILE C 390 −85.401 −54.465 −34.802 1.00 16.48 O ATOM 2575 N ALA C 391 −83.672 −55.401 −35.992 1.00 17.19 N ATOM 2576 CA ALA C 391 −84.461 −56.421 −36.674 1.00 18.85 C ATOM 2577 CB ALA C 391 −84.469 −56.153 −38.165 1.00 16.11 C ATOM 2578 C ALA C 391 −83.831 −57.803 −36.382 1.00 24.01 C ATOM 2579 O ALA C 391 −82.645 −58.040 −36.695 1.00 20.74 O ATOM 2580 N GLN C 392 −84.610 −58.707 −35.786 1.00 22.43 N ATOM 2581 CA GLN C 392 −84.100 −60.077 −35.492 1.00 19.30 C ATOM 2582 CB GLN C 392 −84.066 −60.285 −33.985 1.00 20.48 C ATOM 2583 CG GLN C 392 −85.361 −59.855 −33.340 1.00 30.13 C ATOM 2584 CD GLN C 392 −85.460 −60.267 −31.909 1.00 32.28 C ATOM 2585 OE1 GLN C 392 −84.658 −59.843 −31.088 1.00 31.46 O ATOM 2586 NE2 GLN C 392 −86.471 −61.088 −31.588 1.00 30.56 N ATOM 2587 C GLN C 392 −84.953 −61.159 −36.181 1.00 20.20 C ATOM 2588 O GLN C 392 −86.156 −60.937 −36.460 1.00 22.04 O ATOM 2589 N CYS C 393 −84.355 −62.312 −36.459 1.00 20.74 N ATOM 2590 CA CYS C 393 −85.120 −63.426 −37.033 1.00 21.19 C ATOM 2591 CB CYS C 393 −84.230 −64.638 −37.288 1.00 15.44 C ATOM 2592 SG CYS C 393 −85.130 −66.142 −37.709 1.00 20.71 S ATOM 2593 C CYS C 393 −86.349 −63.803 −36.160 1.00 22.32 C ATOM 2594 O CYS C 393 −86.258 −63.875 −34.924 1.00 22.98 O ATOM 2595 N LYS C 394 −87.496 −63.997 −36.813 1.00 17.78 N ATOM 2596 CA LYS C 394 −88.732 −64.185 −36.098 1.00 20.23 C ATOM 2597 CB LYS C 394 −89.934 −63.980 −37.012 1.00 22.55 C ATOM 2598 CG LYS C 394 −90.334 −65.216 −37.796 1.00 22.60 C ATOM 2599 CD LYS C 394 −91.494 −64.901 −38.719 1.00 29.41 C ATOM 2600 CE LYS C 394 −92.236 −66.164 −39.109 1.00 28.29 C ATOM 2601 NZ LYS C 394 −93.010 −65.901 −40.356 1.00 35.11 N ATOM 2602 C LYS C 394 −88.784 −65.562 −35.450 1.00 20.60 C ATOM 2603 O LYS C 394 −89.586 −65.768 −34.549 1.00 19.59 O ATOM 2604 N ILE C 395 −87.938 −66.495 −35.920 1.00 19.55 N ATOM 2605 CA ILE C 395 −87.909 −67.865 −35.391 1.00 20.31 C ATOM 2606 CB ILE C 395 −87.597 −68.930 −36.497 1.00 19.34 C ATOM 2607 CG1 ILE C 395 −88.668 −68.937 −37.605 1.00 19.02 C ATOM 2608 CD1 ILE C 395 −90.075 −69.306 −37.152 1.00 18.51 C ATOM 2609 CG2 ILE C 395 −87.432 −70.319 −35.882 1.00 21.79 C ATOM 2610 C ILE C 395 −86.936 −68.027 −34.215 1.00 23.66 C ATOM 2611 O ILE C 395 −87.311 −68.538 −33.176 1.00 22.28 O ATOM 2612 N CYS C 396 −85.681 −67.611 −34.391 1.00 23.48 N ATOM 2613 CA CYS C 396 −84.651 −67.877 −33.396 1.00 19.94 C ATOM 2614 CB CYS C 396 −83.462 −68.539 −34.073 1.00 21.17 C ATOM 2615 SG CYS C 396 −82.484 −67.368 −35.033 1.00 24.74 S ATOM 2616 C CYS C 396 −84.192 −66.595 −32.672 1.00 20.15 C ATOM 2617 O CYS C 396 −83.437 −66.669 −31.738 1.00 20.54 O ATOM 2618 N ALA C 397 −84.644 −65.416 −33.138 1.00 23.65 N ATOM 2619 CA ALA C 397 −84.264 −64.113 −32.546 1.00 17.06 C ATOM 2620 CB ALA C 397 −84.537 −64.076 −31.035 1.00 17.73 C ATOM 2621 C ALA C 397 −82.826 −63.674 −32.837 1.00 18.41 C ATOM 2622 O ALA C 397 −82.342 −62.742 −32.204 1.00 17.41 O ATOM 2623 N SER C 398 −82.135 −64.337 −33.778 1.00 18.48 N ATOM 2624 CA SER C 398 −80.791 −63.894 −34.175 1.00 20.01 C ATOM 2625 CB SER C 398 −80.247 −64.776 −35.292 1.00 22.26 C ATOM 2626 OG SER C 398 −79.016 −64.291 −35.796 1.00 24.14 O ATOM 2627 C SER C 398 −80.872 −62.442 −34.657 1.00 21.26 C ATOM 2628 O SER C 398 −81.728 −62.110 −35.477 1.00 20.78 O ATOM 2629 N HIS C 399 −80.012 −61.581 −34.118 1.00 21.72 N ATOM 2630 CA HIS C 399 −79.884 −60.189 −34.580 1.00 28.14 C ATOM 2631 CB HIS C 399 −78.938 −59.420 −33.665 1.00 28.20 C ATOM 2632 CG HIS C 399 −79.591 −58.841 −32.424 1.00 40.47 C ATOM 2633 ND1 HIS C 399 −80.492 −59.521 −31.681 1.00 44.65 N ATOM 2634 CE1 HIS C 399 −80.881 −58.760 −30.636 1.00 39.75 C ATOM 2635 NE2 HIS C 399 −80.223 −57.591 −30.702 1.00 51.18 N ATOM 2636 CD2 HIS C 399 −79.414 −57.606 −31.788 1.00 41.14 C ATOM 2637 C HIS C 399 −79.337 −60.168 −35.999 1.00 27.46 C ATOM 2638 O HIS C 399 −78.131 −60.292 −36.206 1.00 24.27 O ATOM 2639 N ILE C 400 −80.203 −60.036 −36.992 1.00 22.61 N ATOM 2640 CA ILE C 400 −79.754 −60.068 −38.394 1.00 22.27 C ATOM 2641 CB ILE C 400 −80.842 −60.666 −39.334 1.00 19.99 C ATOM 2642 CG1 ILE C 400 −81.257 −62.082 −38.869 1.00 17.08 C ATOM 2643 CD1 ILE C 400 −80.203 −63.115 −39.062 1.00 23.14 C ATOM 2644 CG2 ILE C 400 −80.386 −60.666 −40.807 1.00 16.43 C ATOM 2645 C ILE C 400 −79.325 −58.669 −38.878 1.00 23.99 C ATOM 2646 O ILE C 400 −78.390 −58.542 −39.683 1.00 21.37 O ATOM 2647 N GLY C 401 −80.008 −57.623 −38.401 1.00 19.95 N ATOM 2648 CA GLY C 401 −79.636 −56.263 −38.802 1.00 18.21 C ATOM 2649 C GLY C 401 −80.531 −55.174 −38.281 1.00 18.71 C ATOM 2650 O GLY C 401 −80.907 −55.191 −37.122 1.00 19.32 O ATOM 2651 N TRP C 402 −80.888 −54.225 −39.164 1.00 17.44 N ATOM 2652 CA TRP C 402 −81.726 −53.078 −38.800 1.00 19.31 C ATOM 2653 CB TRP C 402 −80.865 −51.862 −38.399 1.00 20.18 C ATOM 2654 CG TRP C 402 −79.877 −52.174 −37.289 1.00 22.67 C ATOM 2655 CD1 TRP C 402 −80.022 −51.940 −35.933 1.00 22.20 C ATOM 2656 NE1 TRP C 402 −78.907 −52.382 −35.236 1.00 20.05 N ATOM 2657 CE2 TRP C 402 −78.004 −52.923 −36.074 1.00 18.73 C ATOM 2658 CD2 TRP C 402 −78.560 −52.815 −37.432 1.00 24.01 C ATOM 2659 CE3 TRP C 402 −77.817 −53.316 −38.520 1.00 22.95 C ATOM 2660 CZ3 TRP C 402 −76.550 −53.909 −38.248 1.00 25.71 C ATOM 2661 CH2 TRP C 402 −76.044 −53.994 −36.930 1.00 22.33 C ATOM 2662 CZ2 TRP C 402 −76.756 −53.491 −35.824 1.00 22.36 C ATOM 2663 C TRP C 402 −82.674 −52.660 −39.920 1.00 16.44 C ATOM 2664 O TRP C 402 −82.382 −52.831 −41.096 1.00 16.58 O ATOM 2665 N LYS C 403 −83.809 −52.106 −39.544 1.00 15.91 N ATOM 2666 CA LYS C 403 −84.644 −51.400 −40.496 1.00 15.23 C ATOM 2667 CB LYS C 403 −86.111 −51.534 −40.149 1.00 14.73 C ATOM 2668 CG LYS C 403 −87.053 −51.126 −41.296 1.00 17.67 C ATOM 2669 CD LYS C 403 −88.510 −51.063 −40.785 1.00 19.67 C ATOM 2670 CE LYS C 403 −89.540 −51.066 −41.936 1.00 26.44 C ATOM 2671 NZ LYS C 403 −90.902 −50.808 −41.380 1.00 25.88 N ATOM 2672 C LYS C 403 −84.240 −49.961 −40.385 1.00 15.48 C ATOM 2673 O LYS C 403 −84.160 −49.427 −39.264 1.00 16.39 O ATOM 2674 N PHE C 404 −83.992 −49.334 −41.537 1.00 14.03 N ATOM 2675 CA PHE C 404 −83.636 −47.911 −41.590 1.00 14.56 C ATOM 2676 CB PHE C 404 −82.363 −47.709 −42.431 1.00 15.79 C ATOM 2677 CG PHE C 404 −81.085 −48.126 −41.697 1.00 14.77 C ATOM 2678 CD1 PHE C 404 −80.438 −47.220 −40.848 1.00 11.92 C ATOM 2679 CE1 PHE C 404 −79.269 −47.597 −40.134 1.00 16.30 C ATOM 2680 CZ PHE C 404 −78.740 −48.862 −40.289 1.00 14.09 C ATOM 2681 CE2 PHE C 404 −79.356 −49.804 −41.147 1.00 11.55 C ATOM 2682 CD2 PHE C 404 −80.535 −49.433 −41.855 1.00 15.05 C ATOM 2683 C PHE C 404 −84.803 −47.142 −42.168 1.00 16.74 C ATOM 2684 O PHE C 404 −85.342 −47.531 −43.202 1.00 17.23 O ATOM 2685 N THR C 405 −85.234 −46.085 −41.479 1.00 16.28 N ATOM 2686 CA THR C 405 −86.417 −45.367 −41.928 1.00 15.17 C ATOM 2687 CB THR C 405 −87.571 −45.555 −40.914 1.00 19.34 C ATOM 2688 OG1 THR C 405 −87.073 −45.359 −39.590 1.00 18.94 O ATOM 2689 CG2 THR C 405 −88.141 −46.980 −41.007 1.00 20.52 C ATOM 2690 C THR C 405 −86.064 −43.904 −42.078 1.00 17.51 C ATOM 2691 O THR C 405 −85.376 −43.345 −41.220 1.00 14.48 O ATOM 2692 N ALA C 406 −86.519 −43.285 −43.174 1.00 15.65 N ATOM 2693 CA ALA C 406 −86.117 −41.919 −43.531 1.00 18.73 C ATOM 2694 CB ALA C 406 −86.602 −41.565 −44.952 1.00 15.25 C ATOM 2695 C ALA C 406 −86.665 −40.923 −42.534 1.00 19.11 C ATOM 2696 O ALA C 406 −87.776 −41.069 −42.088 1.00 18.20 O ATOM 2697 N THR C 407 −85.861 −39.919 −42.167 1.00 23.17 N ATOM 2698 CA THR C 407 −86.357 −38.856 −41.288 1.00 24.24 C ATOM 2699 CB THR C 407 −85.270 −38.259 −40.353 1.00 21.03 C ATOM 2700 OG1 THR C 407 −84.222 −37.724 −41.147 1.00 22.96 O ATOM 2701 CG2 THR C 407 −84.685 −39.308 −39.404 1.00 23.12 C ATOM 2702 C THR C 407 −87.075 −37.728 −42.051 1.00 28.02 C ATOM 2703 O THR C 407 −87.787 −36.963 −41.435 1.00 30.92 O ATOM 2704 N LYS C 408 −86.889 −37.659 −43.379 1.00 28.82 N ATOM 2705 CA LYS C 408 −87.485 −36.616 −44.269 1.00 34.36 C ATOM 2706 CB LYS C 408 −86.393 −35.691 −44.847 1.00 37.71 C ATOM 2707 CG LYS C 408 −85.845 −34.627 −43.887 1.00 44.88 C ATOM 2708 CD LYS C 408 −84.372 −34.285 −44.146 1.00 48.56 C ATOM 2709 CE LYS C 408 −84.177 −33.276 −45.276 1.00 58.37 C ATOM 2710 NZ LYS C 408 −84.135 −33.931 −46.621 1.00 59.71 N ATOM 2711 C LYS C 408 −88.262 −37.265 −45.434 1.00 34.70 C ATOM 2712 O LYS C 408 −87.899 −38.337 −45.917 1.00 27.93 O ATOM 2713 N LYS C 409 −89.323 −36.615 −45.904 1.00 31.77 N ATOM 2714 CA LYS C 409 −90.167 −37.249 −46.893 1.00 29.16 C ATOM 2715 CB LYS C 409 −91.583 −36.634 −46.907 1.00 41.65 C ATOM 2716 CG LYS C 409 −92.459 −37.029 −45.720 1.00 52.57 C ATOM 2717 CD LYS C 409 −92.489 −38.541 −45.486 1.00 58.96 C ATOM 2718 CE LYS C 409 −93.518 −38.926 −44.430 1.00 61.73 C ATOM 2719 NZ LYS C 409 −94.888 −38.473 −44.820 1.00 70.37 N ATOM 2720 C LYS C 409 −89.558 −37.227 −48.297 1.00 26.22 C ATOM 2721 O LYS C 409 −89.974 −37.990 −49.147 1.00 23.12 O ATOM 2722 N ASP C 410 −88.587 −36.355 −48.536 1.00 26.03 N ATOM 2723 CA ASP C 410 −88.039 −36.173 −49.901 1.00 32.66 C ATOM 2724 CB ASP C 410 −87.531 −34.726 −50.112 1.00 36.81 C ATOM 2725 CG ASP C 410 −86.335 −34.358 −49.191 1.00 48.97 C ATOM 2726 OD1 ASP C 410 −85.842 −35.210 −48.402 1.00 40.68 O ATOM 2727 OD2 ASP C 410 −85.881 −33.197 −49.279 1.00 48.67 O ATOM 2728 C ASP C 410 −86.947 −37.197 −50.306 1.00 36.36 C ATOM 2729 O ASP C 410 −86.488 −37.191 −51.464 1.00 30.60 O ATOM 2730 N MET C 411 −86.533 −38.038 −49.343 1.00 27.26 N ATOM 2731 CA MET C 411 −85.516 −39.093 −49.552 1.00 27.50 C ATOM 2732 CB MET C 411 −84.897 −39.517 −48.192 1.00 20.14 C ATOM 2733 CG MET C 411 −84.070 −38.385 −47.589 1.00 34.07 C ATOM 2734 SD MET C 411 −83.332 −38.664 −45.967 1.00 39.57 S ATOM 2735 CE MET C 411 −84.751 −38.700 −44.911 1.00 26.88 C ATOM 2736 C MET C 411 −86.083 −40.333 −50.276 1.00 27.01 C ATOM 2737 O MET C 411 −87.274 −40.627 −50.198 1.00 20.36 O ATOM 2738 N SER C 412 −85.216 −41.058 −50.973 1.00 22.03 N ATOM 2739 CA SER C 412 −85.595 −42.349 −51.537 1.00 19.59 C ATOM 2740 CB SER C 412 −85.782 −42.280 −53.032 1.00 19.83 C ATOM 2741 OG SER C 412 −84.763 −41.465 −53.592 1.00 25.16 O ATOM 2742 C SER C 412 −84.461 −43.256 −51.120 1.00 20.43 C ATOM 2743 O SER C 412 −83.290 −42.830 −51.270 1.00 16.79 O ATOM 2744 N PRO C 413 −84.758 −44.564 −51.045 1.00 15.16 N ATOM 2745 CA PRO C 413 −85.936 −45.093 −50.394 1.00 16.63 C ATOM 2746 CB PRO C 413 −85.644 −46.608 −50.301 1.00 13.23 C ATOM 2747 CG PRO C 413 −84.187 −46.660 −50.082 1.00 14.85 C ATOM 2748 CD PRO C 413 −83.592 −45.437 −50.799 1.00 12.35 C ATOM 2749 C PRO C 413 −86.361 −44.491 −49.091 1.00 17.58 C ATOM 2750 O PRO C 413 −85.520 −44.078 −48.306 1.00 18.78 O ATOM 2751 N GLN C 414 −87.669 −44.465 −48.841 1.00 14.24 N ATOM 2752 CA GLN C 414 −88.154 −44.057 −47.528 1.00 14.72 C ATOM 2753 CB GLN C 414 −89.675 −43.831 −47.575 1.00 21.18 C ATOM 2754 CG GLN C 414 −90.067 −42.483 −48.210 1.00 16.33 C ATOM 2755 CD GLN C 414 −89.579 −41.324 −47.348 1.00 21.34 C ATOM 2756 OE1 GLN C 414 −88.690 −40.569 −47.471 1.00 25.26 O ATOM 2757 NE2 GLN C 414 −90.121 −41.214 −46.149 1.00 16.87 N ATOM 2758 C GLN C 414 −87.762 −45.052 −46.424 1.00 13.47 C ATOM 2759 O GLN C 414 −87.766 −44.713 −45.251 1.00 13.39 O ATOM 2760 N LYS C 415 −87.425 −46.281 −46.818 1.00 12.81 N ATOM 2761 CA LYS C 415 −87.047 −47.316 −45.887 1.00 17.27 C ATOM 2762 CB LYS C 415 −88.289 −47.969 −45.200 1.00 27.39 C ATOM 2763 CG LYS C 415 −88.907 −49.132 −45.918 1.00 31.26 C ATOM 2764 CD LYS C 415 −90.397 −49.203 −45.631 1.00 40.02 C ATOM 2765 CE LYS C 415 −91.174 −49.680 −46.845 1.00 31.36 C ATOM 2766 NZ LYS C 415 −91.738 −48.555 −47.698 1.00 26.51 N ATOM 2767 C LYS C 415 −86.202 −48.348 −46.638 1.00 15.30 C ATOM 2768 O LYS C 415 −86.316 −48.482 −47.880 1.00 14.31 O ATOM 2769 N PHE C 416 −85.323 −49.018 −45.897 1.00 13.65 N ATOM 2770 CA PHE C 416 −84.531 −50.141 −46.413 1.00 15.39 C ATOM 2771 CB PHE C 416 −83.387 −49.656 −47.344 1.00 15.59 C ATOM 2772 CG PHE C 416 −82.271 −48.919 −46.628 1.00 16.24 C ATOM 2773 CD1 PHE C 416 −81.099 −49.595 −46.218 1.00 14.04 C ATOM 2774 CE1 PHE C 416 −80.082 −48.917 −45.561 1.00 14.00 C ATOM 2775 CZ PHE C 416 −80.209 −47.575 −45.293 1.00 13.70 C ATOM 2776 CE2 PHE C 416 −81.336 −46.880 −45.694 1.00 11.81 C ATOM 2777 CD2 PHE C 416 −82.372 −47.547 −46.361 1.00 15.66 C ATOM 2778 C PHE C 416 −84.005 −50.943 −45.223 1.00 14.79 C ATOM 2779 O PHE C 416 −84.293 −50.597 −44.063 1.00 18.25 O ATOM 2780 N TRP C 417 −83.346 −52.057 −45.513 1.00 12.82 N ATOM 2781 CA TRP C 417 −82.753 −52.922 −44.501 1.00 16.09 C ATOM 2782 CB TRP C 417 −83.332 −54.370 −44.545 1.00 15.43 C ATOM 2783 CG TRP C 417 −84.842 −54.390 −44.515 1.00 13.85 C ATOM 2784 CD1 TRP C 417 −85.704 −54.208 −45.579 1.00 16.56 C ATOM 2785 NE1 TRP C 417 −87.009 −54.284 −45.164 1.00 20.24 N ATOM 2786 CE2 TRP C 417 −87.068 −54.521 −43.830 1.00 19.94 C ATOM 2787 CD2 TRP C 417 −85.701 −54.595 −43.350 1.00 16.94 C ATOM 2788 CE3 TRP C 417 −85.471 −54.829 −42.004 1.00 17.63 C ATOM 2789 CZ3 TRP C 417 −86.563 −54.992 −41.150 1.00 16.62 C ATOM 2790 CH2 TRP C 417 −87.878 −54.912 −41.621 1.00 18.24 C ATOM 2791 CZ2 TRP C 417 −88.163 −54.666 −42.975 1.00 20.48 C ATOM 2792 C TRP C 417 −81.265 −52.953 −44.638 1.00 18.16 C ATOM 2793 O TRP C 417 −80.720 −53.149 −45.731 1.00 20.68 O ATOM 2794 N GLY C 418 −80.588 −52.768 −43.514 1.00 15.54 N ATOM 2795 CA GLY C 418 −79.139 −52.996 −43.460 1.00 19.03 C ATOM 2796 C GLY C 418 −78.935 −54.289 −42.693 1.00 15.90 C ATOM 2797 O GLY C 418 −79.321 −54.390 −41.516 1.00 14.11 O ATOM 2798 N LEU C 419 −78.413 −55.291 −43.391 1.00 17.31 N ATOM 2799 CA LEU C 419 −78.292 −56.641 −42.840 1.00 19.06 C ATOM 2800 CB LEU C 419 −79.000 −57.661 −43.777 1.00 17.16 C ATOM 2801 CG LEU C 419 −80.480 −57.343 −44.085 1.00 18.47 C ATOM 2802 CD1 LEU C 419 −81.105 −58.334 −45.062 1.00 20.53 C ATOM 2803 CD2 LEU C 419 −81.304 −57.258 −42.793 1.00 18.86 C ATOM 2804 C LEU C 419 −76.781 −57.013 −42.598 1.00 20.83 C ATOM 2805 O LEU C 419 −75.894 −56.709 −43.412 1.00 21.07 O ATOM 2806 N THR C 420 −76.502 −57.662 −41.474 1.00 22.24 N ATOM 2807 CA THR C 420 −75.119 −58.099 −41.172 1.00 21.28 C ATOM 2808 CB THR C 420 −74.935 −58.384 −39.665 1.00 22.15 C ATOM 2809 OG1 THR C 420 −75.288 −57.206 −38.933 1.00 21.18 O ATOM 2810 CG2 THR C 420 −73.468 −58.760 −39.315 1.00 25.70 C ATOM 2811 C THR C 420 −74.863 −59.312 −42.006 1.00 17.49 C ATOM 2812 O THR C 420 −75.555 −60.293 −41.864 1.00 19.47 O ATOM 2813 N ARG C 421 −73.902 −59.221 −42.929 1.00 16.40 N ATOM 2814 CA ARG C 421 −73.645 −60.311 −43.884 1.00 22.27 C ATOM 2815 CB ARG C 421 −72.481 −59.993 −44.803 1.00 22.53 C ATOM 2816 CG ARG C 421 −72.879 −59.341 −46.098 1.00 29.03 C ATOM 2817 CD ARG C 421 −71.623 −58.991 −46.899 1.00 38.94 C ATOM 2818 NE ARG C 421 −71.919 −58.145 −48.051 1.00 44.04 N ATOM 2819 CZ ARG C 421 −71.983 −58.581 −49.306 1.00 44.92 C ATOM 2820 NH1 ARG C 421 −71.752 −59.863 −49.594 1.00 50.35 N ATOM 2821 NH2 ARG C 421 −72.266 −57.728 −50.276 1.00 45.31 N ATOM 2822 C ARG C 421 −73.312 −61.617 −43.188 1.00 20.53 C ATOM 2823 O ARG C 421 −73.675 −62.682 −43.684 1.00 19.34 O ATOM 2824 N SER C 422 −72.615 −61.532 −42.052 1.00 19.89 N ATOM 2825 CA SER C 422 −72.101 −62.726 −41.412 1.00 21.25 C ATOM 2826 CB SER C 422 −70.952 −62.397 −40.441 1.00 22.28 C ATOM 2827 OG SER C 422 −71.392 −61.587 −39.355 1.00 23.24 O ATOM 2828 C SER C 422 −73.265 −63.425 −40.709 1.00 26.68 C ATOM 2829 O SER C 422 −73.121 −64.557 −40.217 1.00 26.13 O ATOM 2830 N ALA C 423 −74.427 −62.754 −40.680 1.00 20.09 N ATOM 2831 CA ALA C 423 −75.600 −63.319 −40.034 1.00 22.85 C ATOM 2832 CB ALA C 423 −76.373 −62.248 −39.254 1.00 20.19 C ATOM 2833 C ALA C 423 −76.503 −64.027 −41.026 1.00 20.26 C ATOM 2834 O ALA C 423 −77.602 −64.437 −40.678 1.00 19.34 O ATOM 2835 N LEU C 424 −76.030 −64.196 −42.256 1.00 18.13 N ATOM 2836 CA LEU C 424 −76.859 −64.803 −43.308 1.00 19.56 C ATOM 2837 CB LEU C 424 −77.266 −63.740 −44.343 1.00 20.60 C ATOM 2838 CG LEU C 424 −78.143 −62.550 −43.936 1.00 20.34 C ATOM 2839 CD1 LEU C 424 −78.203 −61.482 −45.054 1.00 19.36 C ATOM 2840 CD2 LEU C 424 −79.530 −63.018 −43.543 1.00 21.80 C ATOM 2841 C LEU C 424 −76.084 −65.917 −44.011 1.00 24.43 C ATOM 2842 O LEU C 424 −74.866 −65.827 −44.109 1.00 23.18 O ATOM 2843 N LEU C 425 −76.785 −66.943 −44.510 1.00 25.17 N ATOM 2844 CA LEU C 425 −76.167 −68.016 −45.339 1.00 33.88 C ATOM 2845 CB LEU C 425 −76.579 −69.428 −44.864 1.00 30.99 C ATOM 2846 CG LEU C 425 −75.602 −70.309 −44.053 1.00 36.36 C ATOM 2847 CD1 LEU C 425 −76.026 −71.768 −44.169 1.00 32.35 C ATOM 2848 CD2 LEU C 425 −74.142 −70.153 −44.465 1.00 26.75 C ATOM 2849 C LEU C 425 −76.429 −67.841 −46.861 1.00 43.24 C ATOM 2850 O LEU C 425 −77.442 −67.256 −47.238 1.00 44.94 O ATOM 2851 N PRO C 426 −75.647 −68.566 −47.708 1.00 63.22 N ATOM 2852 CA PRO C 426 −74.702 −68.070 −48.683 1.00 54.32 C ATOM 2853 CB PRO C 426 −75.608 −67.764 −49.874 1.00 49.23 C ATOM 2854 CG PRO C 426 −76.642 −68.885 −49.793 1.00 54.01 C ATOM 2855 CD PRO C 426 −76.513 −69.528 −48.407 1.00 62.25 C ATOM 2856 C PRO C 426 −73.830 −66.886 −48.210 1.00 63.22 C ATOM 2857 O PRO C 426 −73.786 −66.592 −47.020 1.00 56.35 O ATOM 2858 N THR C 427 −73.099 −66.262 −49.133 1.00 84.63 N ATOM 2859 CA THR C 427 −72.073 −65.264 −48.780 1.00 77.10 C ATOM 2860 CB THR C 427 −70.645 −65.857 −48.915 1.00 67.64 C ATOM 2861 OG1 THR C 427 −70.595 −67.137 −48.272 1.00 65.52 O ATOM 2862 CG2 THR C 427 −69.586 −64.936 −48.284 1.00 57.97 C ATOM 2863 C THR C 427 −72.200 −64.004 −49.643 1.00 79.60 C ATOM 2864 O THR C 427 −71.996 −62.882 −49.169 1.00 75.88 O ATOM 2865 O4 SO4 E 1 −54.723 −44.990 −18.711 1.00 34.87 O ATOM 2866 S SO4 E 1 −53.926 −46.019 −19.445 1.00 30.33 S ATOM 2867 O1 SO4 E 1 −52.667 −45.226 −19.497 1.00 40.69 O ATOM 2868 O2 SO4 E 1 −54.494 −46.521 −20.711 1.00 37.83 O ATOM 2869 O3 SO4 E 1 −53.762 −47.313 −18.685 1.00 27.49 O ATOM 2870 O4 SO4 E 2 −51.527 −50.153 −19.351 1.00 28.72 O ATOM 2871 S SO4 E 2 −51.025 −50.912 −20.507 1.00 28.44 S ATOM 2872 O1 SO4 E 2 −50.193 −50.041 −21.305 1.00 31.03 O ATOM 2873 O2 SO4 E 2 −52.120 −51.432 −21.333 1.00 26.16 O ATOM 2874 O3 SO4 E 2 −50.189 −52.060 −20.032 1.00 36.16 O ATOM 2875 O4 SO4 E 3 −45.929 −50.344 −17.864 1.00 36.74 O ATOM 2876 S SO4 E 3 −45.906 −51.755 −18.032 1.00 37.79 S ATOM 2877 O1 SO4 E 3 −45.165 −52.128 −19.289 1.00 36.69 O ATOM 2878 O2 SO4 E 3 −47.343 −52.087 −18.010 1.00 36.35 O ATOM 2879 O3 SO4 E 3 −45.071 −52.414 −17.008 1.00 32.89 O ATOM 2880 O4 SO4 E 4 −53.189 −53.605 −24.266 1.00 25.07 O ATOM 2881 S SO4 E 4 −52.543 −53.562 −25.609 1.00 29.75 S ATOM 2882 O1 SO4 E 4 −52.690 −52.307 −26.353 1.00 31.43 O ATOM 2883 O2 SO4 E 4 −53.119 −54.654 −26.453 1.00 30.96 O ATOM 2884 O3 SO4 E 4 −51.141 −53.819 −25.399 1.00 35.91 O ATOM 2885 O4 SO4 E 5 −89.973 −45.891 −49.829 1.00 49.41 O ATOM 2886 S SO4 E 5 −90.034 −45.443 −51.227 1.00 37.09 S ATOM 2887 O1 SO4 E 5 −88.890 −44.623 −51.635 1.00 38.19 O ATOM 2888 O2 SO4 E 5 −91.168 −44.526 −51.511 1.00 32.01 O ATOM 2889 O3 SO4 E 5 −90.041 −46.709 −52.003 1.00 29.16 O ATOM 2890 O4 SO4 E 6 −93.866 −50.074 −49.055 0.33 20.68 O ATOM 2891 S SO4 E 6 −92.762 −50.233 −50.044 0.33 21.45 S ATOM 2892 O1 SO4 E 6 −92.281 −48.910 −50.439 0.50 34.02 O ATOM 2893 O2 SO4 E 6 −93.220 −50.982 −51.213 0.50 23.08 O ATOM 2894 O3 SO4 E 6 −91.592 −50.923 −49.480 0.50 23.75 O ATOM 2895 O4 SO4 E 7 −38.497 −35.089 1.178 1.00 71.25 O ATOM 2896 S SO4 E 7 −39.233 −35.117 −0.107 1.00 66.22 S ATOM 2897 O1 SO4 E 7 −38.459 −34.457 −1.177 1.00 57.19 O ATOM 2898 O2 SO4 E 7 −40.518 −34.397 0.034 1.00 56.79 O ATOM 2899 O3 SO4 E 7 −39.496 −36.525 −0.455 1.00 58.08 O ATOM 2900 O4 SO4 E 8 −72.907 −38.605 −33.750 1.00 59.22 O ATOM 2901 S SO4 E 8 −72.391 −39.680 −34.641 1.00 69.73 S ATOM 2902 O1 SO4 E 8 −71.128 −39.280 −35.293 1.00 71.09 O ATOM 2903 O2 SO4 E 8 −73.339 −39.990 −35.730 1.00 71.11 O ATOM 2904 O3 SO4 E 8 −72.188 −40.888 −33.811 1.00 57.92 O ATOM 2905 ZN ZN F 1 −37.031 −60.796 −4.821 1.00 21.11 ZN ATOM 2906 ZN ZN F 2 −62.197 −67.575 −32.859 1.00 34.85 ZN ATOM 2907 ZN ZN F 3 −83.278 −67.696 −37.358 1.00 39.65 ZN ATOM 2908 ZN ZN F 4 −67.622 −38.280 −9.187 1.00 18.91 ZN ATOM 2909 O2 MOL G 1 −34.200 −69.411 −20.877 1.00 27.56 O ATOM 2910 C3 MOL G 1 −33.576 −69.176 −21.908 1.00 36.52 C ATOM 2911 C7 MOL G 1 −32.221 −69.428 −22.134 1.00 33.94 C ATOM 2912 C10 MOL G 1 −31.201 −69.975 −21.356 1.00 43.15 C ATOM 2913 N3 MOL G 1 −31.457 −70.383 −20.108 1.00 38.82 N ATOM 2914 C13 MOL G 1 −29.917 −70.097 −21.889 1.00 35.85 C ATOM 2915 C12 MOL G 1 −29.660 −69.675 −23.196 1.00 38.37 C ATOM 2916 C9 MOL G 1 −30.685 −69.125 −23.972 1.00 40.85 C ATOM 2917 C6 MOL G 1 −31.966 −69.007 −23.435 1.00 35.10 C ATOM 2918 C2 MOL G 1 −33.183 −68.522 −23.928 1.00 36.53 C ATOM 2919 O1 MOL G 1 −33.362 −68.060 −25.052 1.00 35.98 O ATOM 2920 N1 MOL G 1 −34.116 −68.632 −22.985 1.00 36.13 N ATOM 2921 C1 MOL G 1 −35.541 −68.279 −23.090 1.00 33.12 C ATOM 2922 C5 MOL G 1 −35.820 −66.773 −23.072 1.00 27.50 C ATOM 2923 C8 MOL G 1 −37.351 −66.569 −23.137 1.00 26.34 C ATOM 2924 C11 MOL G 1 −37.942 −67.284 −24.368 1.00 34.06 C ATOM 2925 O4 MOL G 1 −38.958 −66.857 −24.914 1.00 24.63 O ATOM 2926 N2 MOL G 1 −37.303 −68.411 −24.913 1.00 24.70 N ATOM 2927 C4 MOL G 1 −36.149 −68.941 −24.337 1.00 34.50 C ATOM 2928 O3 MOL G 1 −35.632 −69.951 −24.829 1.00 28.91 O ATOM 2929 O2 MOL H 1 −70.412 −51.591 −36.451 1.00 34.85 O ATOM 2930 C3 MOL H 1 −70.148 −50.572 −37.091 1.00 33.52 C ATOM 2931 C7 MOL H 1 −70.413 −50.373 −38.445 1.00 44.01 C ATOM 2932 C10 MOL H 1 −70.987 −51.161 −39.437 1.00 44.10 C ATOM 2933 N3 MOL H 1 −71.413 −52.388 −39.153 1.00 49.44 N ATOM 2934 C13 MOL H 1 −71.109 −50.657 −40.730 1.00 42.96 C ATOM 2935 C12 MOL H 1 −70.660 −49.370 −41.023 1.00 48.49 C ATOM 2936 C9 MOL H 1 −70.089 −48.581 −40.027 1.00 40.03 C ATOM 2937 C6 MOL H 1 −69.967 −49.088 −38.740 1.00 39.17 C ATOM 2938 C2 MOL H 1 −69.454 −48.571 −37.553 1.00 37.80 C ATOM 2939 O1 MOL H 1 −68.974 −47.448 −37.429 1.00 39.09 O ATOM 2940 N1 MOL H 1 −69.573 −49.482 −36.587 1.00 32.80 N ATOM 2941 Cl MOL H 1 −69.184 −49.332 −35.177 1.00 26.39 C ATOM 2942 C5 MOL H 1 −67.676 −49.236 −34.973 1.00 27.10 C ATOM 2943 C8 MOL H 1 −67.386 −49.108 −33.468 1.00 26.29 C ATOM 2944 C11 MOL H 1 −68.167 −47.913 −32.865 1.00 34.99 C ATOM 2945 O4 MOL H 1 −67.742 −47.318 −31.879 1.00 24.22 O ATOM 2946 N2 MOL H 1 −69.361 −47.473 −33.450 1.00 27.76 N ATOM 2947 C4 MOL H 1 −69.893 −48.117 −34.567 1.00 32.09 C ATOM 2948 O3 MOL H 1 −70.950 −47.709 −35.049 1.00 34.63 O ATOM 2949 O2 MOL I 1 −76.040 −47.643 −32.032 1.00 37.97 O ATOM 2950 C3 MOL I 1 −75.540 −48.769 −31.955 1.00 44.24 C ATOM 2951 C7 MOL I 1 −75.026 −49.356 −30.798 1.00 40.46 C ATOM 2952 C10 MOL I 1 −74.907 −48.934 −29.478 1.00 46.25 C ATOM 2953 N3 MOL I 1 −75.341 −47.730 −29.121 1.00 49.70 N ATOM 2954 C13 MOL I 1 −74.328 −49.781 −28.532 1.00 49.75 C ATOM 2955 C12 MOL I 1 −73.867 −51.046 −28.909 1.00 43.94 C ATOM 2956 C9 MOL I 1 −73.986 −51.474 −30.230 1.00 37.98 C ATOM 2957 C6 MOL I 1 −74.570 −50.621 −31.170 1.00 50.63 C ATOM 2958 C2 MOL I 1 −74.831 −50.734 −32.530 1.00 31.69 C ATOM 2959 O1 MOL I 1 −74.567 −51.710 −33.226 1.00 37.63 O ATOM 2960 N1 MOL I 1 −75.426 −49.629 −32.962 1.00 38.07 N ATOM 2961 C1 MOL I 1 −75.793 −49.383 −34.361 1.00 32.47 C ATOM 2962 C5 MOL I 1 −77.282 −49.343 −34.659 1.00 32.69 C ATOM 2963 C8 MOL I 1 −77.459 −49.145 −36.182 1.00 24.85 C ATOM 2964 C11 MOL I 1 −76.729 −47.885 −36.648 1.00 32.62 C ATOM 2965 O4 MOL I 1 −77.127 −47.254 −37.626 1.00 31.31 O ATOM 2966 N2 MOL I 1 −75.611 −47.417 −35.947 1.00 35.82 N ATOM 2967 C4 MOL I 1 −75.124 −48.101 −34.830 1.00 36.64 C ATOM 2968 O3 MOL I 1 −74.144 −47.667 −34.226 1.00 37.07 O ATOM 2969 O2 MOL J 1 −51.166 −33.977 −1.714 1.00 26.79 O ATOM 2970 C3 MOL J 1 −50.182 −33.313 −2.043 1.00 35.16 C ATOM 2971 C7 MOL J 1 −50.003 −31.940 −1.839 1.00 34.70 C ATOM 2972 C10 MOL J 1 −50.775 −30.390 −1.260 1.00 47.54 C ATOM 2973 N3 MOL J 1 −51.973 −31.201 −0.748 1.00 44.74 N ATOM 2974 C13 MOL J 1 −50.285 −29.627 −1.215 1.00 43.00 C ATOM 2975 C12 MOL J 1 −49.030 −29.327 −1.748 1.00 46.18 C ATOM 2976 C9 MOL J 1 −48.259 −30.334 −2.326 1.00 43.91 C ATOM 2977 C6 MOL J 1 −48.750 −31.637 −2.363 1.00 38.39 C ATOM 2978 C2 MOL J 1 −48.239 −32.834 −2.860 1.00 38.93 C ATOM 2979 O1 MOL J 1 −47.149 −32.962 −3.403 1.00 33.84 O ATOM 2980 N1 MOL J 1 −49.116 −33.811 −2.665 1.00 33.72 N ATOM 2981 C1 MOL J 1 −48.931 −35.230 −3.014 1.00 30.72 C ATOM 2982 C5 MOL J 1 −48.985 −35.480 −4.524 1.00 30.17 C ATOM 2983 C8 MOL J 1 −48.785 −36.983 −4.775 1.00 26.35 C ATOM 2894 C11 MOL J 1 −47.442 −37.432 −4.172 1.00 25.72 C ATOM 2985 O4 MOL J 1 −46.806 −38.375 −4.643 1.00 25.05 O ATOM 2986 N2 MOL J 1 −46.914 −36.775 −3.064 1.00 25.10 N ATOM 2987 C4 MOL J 1 −47.589 −35.729 −2.449 1.00 32.42 C ATOM 2988 O3 MOL J 1 −47.067 −35.184 −1.474 1.00 28.67 O ATOM 2989 O HOH L 1 −55.998 −46.780 −16.632 1.00 16.83 O ATOM 2990 O HOH L 2 −56.662 −50.434 −20.736 1.00 22.13 O ATOM 2991 O HOH L 3 −57.457 −62.815 −22.052 1.00 22.58 O ATOM 2292 O HOH L 4 −50.618 −49.881 −15.145 1.00 17.57 O ATOM 2993 O HOH L 5 −62.861 −49.113 −13.580 1.00 14.78 O ATOM 2994 O HOH L 6 −87.525 −50.331 −49.601 1.00 26.21 O ATOM 2995 O HOH L 7 −50.314 −56.170 −20.940 1.00 19.17 O ATOM 2996 O HOH L 8 −80.691 −48.641 −56.456 1.00 26.94 O ATOM 2997 O HOH L 9 −87.823 −46.397 −53.706 1.00 25.56 O ATOM 2998 O HOH L 10 −46.766 −54.212 −15.948 1.00 19.85 O ATOM 2999 O HOH L 11 −54.689 −56.062 −24.289 1.00 23.71 O ATOM 3000 O HOH L 12 −52.966 −46.978 −15.788 1.00 38.48 O ATOM 3001 O HOH L 13 −70.006 −44.488 −54.878 1.00 37.18 O ATOM 3002 O HOH L 14 −86.569 −56.779 −56.779 0.33 28.69 O ATOM 3003 O HOH L 15 −48.350 −56.993 −8.676 1.00 17.51 O ATOM 3004 O HOH L 16 −68.984 −42.767 −19.765 1.00 32.38 O ATOM 3005 O HOH L 17 −68.766 −45.836 −14.618 1.00 21.41 O ATOM 3006 O HOH L 18 −65.146 −38.900 −4.467 1.00 18.16 O ATOM 3007 O HOH L 19 −68.794 −50.045 −19.943 1.00 19.10 O ATOM 3008 O HOH L 20 −41.638 −50.487 −9.646 1.00 33.30 O ATOM 3009 O HOH L 21 −55.593 −52.942 −23.585 1.00 32.75 O ATOM 3010 O HOH L 22 −68.516 −37.192 −1.213 1.00 22.05 O ATOM 3011 O HOH L 23 −66.402 −41.857 −23.656 1.00 30.19 O ATOM 3012 O HOH L 24 −48.949 −50.259 −3.117 1.00 20.76 O ATOM 3013 O HOH L 25 −59.009 −39.873 3.409 1.00 42.32 O ATOM 3014 O HOH L 26 −45.918 −30.169 −4.736 1.00 46.91 O ATOM 3015 O HOH L 27 −53.478 −54.143 −29.145 1.00 31.57 O ATOM 3016 O HOH L 28 −45.909 −43.969 −18.007 1.00 32.99 O ATOM 3017 O HOH L 29 −51.066 −32.431 −11.268 1.00 24.78 O ATOM 3018 O HOH L 30 −42.216 −73.166 −12.977 1.00 37.86 O ATOM 3019 O HOH L 31 −72.079 −41.347 −1.326 1.00 22.25 O ATOM 3020 O HOH L 32 −54.117 −56.765 −9.916 1.00 22.66 O ATOM 3021 O HOH L 33 −66.620 −39.520 −32.360 1.00 32.68 O ATOM 3022 O HOH L 34 −70.408 −47.023 −16.690 1.00 39.78 O ATOM 3023 O HOH L 35 −50.740 −68.469 −21.748 1.00 23.44 O ATOM 3024 O HOH L 36 −51.584 −68.740 −28.925 1.00 39.50 O ATOM 3025 O HOH L 38 −48.263 −36.102 −27.104 1.00 57.58 O ATOM 3026 O HOH L 39 −58.423 −42.724 2.518 1.00 29.07 O ATOM 3027 O HOH L 40 −53.892 −50.012 −31.849 1.00 41.54 O ATOM 3028 O HOH L 41 −47.670 −65.760 −29.776 1.00 31.59 O ATOM 3029 O HOH L 42 −49.846 −54.290 −23.795 1.00 28.15 O ATOM 3030 O HOH L 43 −47.985 −49.554 −17.319 1.00 25.72 O ATOM 3031 O HOH L 44 −61.111 −54.780 −13.858 1.00 24.25 O ATOM 3032 O HOH L 45 −48.006 −38.612 −13.475 1.00 27.50 O ATOM 3033 O HOH L 46 −56.939 −67.279 −18.170 1.00 26.47 O ATOM 3034 O HOH L 47 −54.216 −65.125 −3.060 1.00 44.65 O ATOM 3035 O HOH L 48 −41.288 −46.688 −5.936 1.00 29.34 O ATOM 3036 O HOH L 49 −54.648 −41.941 −18.547 1.00 34.86 O ATOM 3037 O HOH L 51 −54.304 −45.291 −26.731 1.00 32.28 O ATOM 3038 O HOH L 52 −31.964 −45.046 −12.913 1.00 50.59 O ATOM 3039 O HOH L 53 −39.705 −51.924 −10.982 1.00 29.79 O ATOM 3040 O HOH L 54 −51.979 −56.736 −3.857 1.00 27.27 O ATOM 3041 O HOH L 55 −73.920 −44.260 −45.398 1.00 48.40 O ATOM 3042 O HOH L 56 −73.014 −46.304 −14.894 1.00 49.60 O ATOM 3043 O HOH L 57 −40.895 −63.873 −32.083 1.00 26.43 O ATOM 3044 O HOH L 58 −79.228 −56.277 −35.237 1.00 32.93 O ATOM 3045 O HOH L 59 −58.554 −47.824 −31.954 1.00 23.44 O ATOM 3046 O HOH L 61 −48.750 −55.157 −37.860 1.00 44.89 O ATOM 3047 O HOH L 62 −66.361 −56.331 −34.426 1.00 31.05 O ATOM 3048 O HOH L 63 −41.194 −31.862 −11.284 1.00 43.11 O ATOM 3049 O HOH L 64 −39.461 −57.916 −24.583 1.00 29.48 O ATOM 3050 O HOH L 65 −73.595 −37.914 −3.101 1.00 32.42 O ATOM 3051 O HOH L 66 −67.508 −62.007 −37.869 1.00 37.16 O ATOM 3052 O HOH L 67 −57.878 −57.181 −5.043 1.00 26.23 O ATOM 3053 O HOH L 68 −72.613 −47.621 −11.983 1.00 48.77 O ATOM 3054 O HOH L 69 −30.921 −56.088 −6.315 1.00 41.67 O ATOM 3055 O HOH L 70 −54.655 −52.405 −1.180 1.00 36.06 O ATOM 3056 O HOH L 71 −58.796 −48.586 −41.581 1.00 44.72 O ATOM 3057 O HOH L 72 −65.399 −67.585 −16.007 1.00 49.35 O ATOM 3058 O HOH L 74 −41.681 −50.450 −3.778 1.00 40.39 O ATOM 3059 O HOH L 75 −82.168 −54.170 −56.506 1.00 35.36 O ATOM 3060 O HOH L 76 −71.740 −53.589 −35.005 1.00 41.35 O ATOM 3061 O HOH L 77 −73.389 −60.629 −20.406 1.00 65.00 O ATOM 3062 O HOH L 78 −47.960 −43.267 −18.897 1.00 37.35 O ATOM 3063 O HOH L 79 −39.379 −66.297 −32.756 1.00 30.34 O ATOM 3064 O HOH L 80 −78.068 −55.318 −33.205 1.00 40.39 O ATOM 3065 O HOH L 81 −57.063 −57.327 −13.895 1.00 21.99 O ATOM 3066 O HOH L 82 −55.365 −55.336 −15.755 1.00 20.36 O ATOM 3067 O HOH L 83 −67.023 −65.067 −31.961 1.00 33.22 O ATOM 3068 O HOH L 85 −35.520 −64.612 −16.134 1.00 34.96 O ATOM 3069 O HOH L 86 −68.461 −57.366 −33.035 1.00 35.10 O ATOM 3070 O HOH L 87 −73.400 −55.363 −38.890 1.00 44.25 O ATOM 3071 O HOH L 88 −66.947 −52.024 −37.561 1.00 38.14 O ATOM 3072 O HOH L 90 −61.619 −40.178 −18.597 1.00 29.35 O ATOM 3073 O HOH L 91 −51.419 −62.600 −29.502 1.00 33.22 O ATOM 3074 O HOH L 92 −37.856 −39.688 −10.228 1.00 40.42 O ATOM 3075 O HOH L 93 −86.112 −47.545 −37.999 1.00 29.15 O ATOM 3076 O HOH L 94 −62.880 −41.964 −20.114 1.00 33.78 O ATOM 3077 O HOH L 95 −65.313 −40.867 −21.154 1.00 35.39 O ATOM 3078 O HOH L 96 −69.416 −54.581 −8.419 1.00 32.62 O ATOM 3079 O HOH L 97 −75.300 −59.197 −30.841 1.00 54.15 O ATOM 3080 O HOH L 98 −65.831 −58.654 −13.239 1.00 31.44 O ATOM 3081 O HOH L 100 −70.424 −33.186 −15.560 1.00 33.39 O ATOM 3082 O HOH L 101 −44.643 −55.547 −3.013 1.00 28.01 O ATOM 3083 O HOH L 102 −46.432 −53.101 −37.062 1.00 42.42 O ATOM 3084 O HOH L 103 −70.364 −54.480 −10.693 1.00 39.13 O ATOM 3085 O HOH L 104 −31.478 −67.848 −26.883 1.00 48.60 O ATOM 3086 O HOH L 105 −40.414 −70.438 −17.098 1.00 35.54 O ATOM 3087 O HOH L 107 −63.118 −62.722 −12.135 1.00 40.48 O ATOM 3088 O HOH L 108 −50.731 −39.550 −18.176 1.00 50.25 O ATOM 3089 O HOH L 109 −37.743 −65.752 −7.100 1.00 26.28 O ATOM 3090 O HOH L 111 −54.285 −72.272 −28.250 1.00 47.18 O ATOM 3091 O HOH L 112 −39.326 −74.029 −13.072 1.00 47.17 O ATOM 3092 O HOH L 113 −54.743 −40.472 −0.259 1.00 30.05 O ATOM 3093 O HOH L 114 −86.348 −75.737 −43.976 1.00 54.17 O ATOM 3094 O HOH L 115 −67.070 −48.290 0.624 1.00 52.78 O ATOM 3095 O HOH L 116 −41.314 −62.221 −34.289 1.00 42.38 O ATOM 3096 O HOH L 117 −47.339 −69.859 −27.729 1.00 50.42 O ATOM 3097 O HOH L 118 −55.943 −64.679 −1.086 1.00 51.95 O ATOM 3098 O HOH L 119 −36.936 −68.180 −6.143 1.00 26.78 O ATOM 3099 O HOH L 120 −39.365 −60.321 −35.436 1.00 47.69 O ATOM 3100 O HOH L 121 −56.768 −62.719 0.272 1.00 38.13 O ATOM 3101 O HOH L 122 −51.787 −33.032 −5.129 1.00 36.07 O ATOM 3102 O HOH L 123 −56.231 −35.993 −5.765 1.00 30.83 O ATOM 3103 O HOH L 124 −40.242 −68.209 −0.005 1.00 30.45 O ATOM 3104 O HOH L 125 −57.016 −37.559 −3.217 1.00 27.01 O ATOM 3105 O HOH L 126 −56.879 −61.381 −16.376 1.00 24.94 O ATOM 3106 O HOH L 127 −56.342 −35.508 −1.199 1.00 43.91 O ATOM 3107 O HOH L 128 −68.368 −53.928 −18.982 1.00 31.58 O ATOM 3108 O HOH L 129 −62.786 −47.406 −0.550 1.00 28.32 O ATOM 3109 O HOH L 130 −69.999 −55.296 −17.499 1.00 38.41 O ATOM 3110 O HOH L 131 −75.671 −53.931 −50.478 1.00 37.36 O ATOM 3111 O HOH L 132 −46.115 −56.050 −0.755 1.00 42.66 O ATOM 3112 O HOH L 133 −50.828 −68.384 −17.490 1.00 39.60 O ATOM 3113 O HOH L 134 −74.987 −45.384 −54.535 1.00 29.72 O ATOM 3114 O HOH L 135 −64.661 −45.243 1.729 1.00 39.44 O ATOM 3115 O HOH L 136 −81.295 −41.740 −49.705 1.00 30.27 O ATOM 3116 O HOH L 137 −55.673 −58.104 −7.014 1.00 32.53 O ATOM 3117 O HOH L 138 −63.905 −56.458 −12.710 1.00 30.10 O ATOM 3118 O HOH L 139 −31.190 −57.977 −28.665 1.00 43.45 O ATOM 3119 O HOH L 140 −39.876 −39.749 −8.199 1.00 27.49 O ATOM 3120 O HOH L 141 −56.589 −68.929 −25.262 1.00 37.89 O ATOM 3121 O HOH L 142 −42.270 −52.387 −17.773 1.00 32.52 O ATOM 3122 O HOH L 143 −69.361 −40.450 −31.496 1.00 32.62 O ATOM 3123 O HOH L 144 −52.911 −62.032 −1.169 1.00 39.62 O ATOM 3124 O HOH L 145 −64.485 −40.022 −30.570 1.00 30.56 O ATOM 3125 O HOH L 146 −40.173 −55.926 −0.786 1.00 29.73 O ATOM 3126 O HOH L 147 −91.725 −39.677 −50.031 1.00 42.43 O ATOM 3127 O HOH L 148 −83.022 −40.758 −31.882 1.00 39.88 O ATOM 3128 O HOH L 149 −29.384 −71.387 −29.309 1.00 46.26 O ATOM 3129 O HOH L 150 −33.094 −65.936 −20.202 1.00 45.04 O ATOM 3130 O HOH L 151 −70.060 −72.294 −29.785 1.00 32.81 O ATOM 3131 O HOH L 152 −49.652 −36.909 −16.537 1.00 42.75 O ATOM 3132 O HOH L 153 −37.015 −67.403 −14.818 1.00 32.50 O ATOM 3133 O HOH L 154 −32.607 −52.859 −14.840 1.00 38.65 O ATOM 3134 O HOH L 155 −74.055 −63.198 −46.721 1.00 46.56 O ATOM 3135 O HOH L 156 −70.883 −58.870 −41.837 1.00 48.30 O ATOM 3136 O HOH L 157 −48.307 −32.834 −11.109 1.00 31.32 O ATOM 3137 O HOH L 158 −46.437 −69.854 −8.165 1.00 38.79 O ATOM 3138 O HOH L 159 −32.484 −66.271 −10.245 1.00 30.51 O ATOM 3139 O HOH L 160 −73.974 −58.768 −27.568 1.00 43.88 O ATOM 3140 O HOH L 161 −75.864 −60.065 −25.979 1.00 47.84 O ATOM 3141 O HOH L 162 −67.335 −53.177 −13.731 1.00 32.22 O ATOM 3142 O HOH L 163 −62.473 −38.200 −30.448 1.00 35.09 O ATOM 3143 O HOH L 164 −65.673 −32.093 −14.729 1.00 41.89 O ATOM 3144 O HOH L 165 −62.402 −32.999 −4.269 1.00 26.95 O ATOM 3145 O HOH L 166 −73.108 −38.320 −0.555 1.00 29.99 O ATOM 3146 O HOH L 167 −65.889 −37.667 −2.033 1.00 30.57 O ATOM 3147 O HOH L 168 −67.916 −32.091 −2.460 1.00 39.98 O ATOM 3148 O HOH L 169 −69.724 −33.316 −0.530 1.00 38.04 O ATOM 3149 O HOH L 170 −55.430 −49.098 −33.848 1.00 44.42 O ATOM 3150 O HOH L 171 −61.069 −51.087 −38.110 1.00 36.65 O ATOM 3151 O HOH L 172 −75.354 −49.720 −49.526 1.00 33.61 O ATOM 3152 O HOH L 173 −78.168 −52.308 −31.917 1.00 47.08 O ATOM 3153 O HOH L 174 −67.475 −55.441 −36.645 1.00 40.30 O ATOM 3154 O HOH L 175 −62.020 −42.247 −40.422 1.00 42.03 O ATOM 3155 O HOH L 176 −52.158 −62.111 −33.880 1.00 34.20 O ATOM 3156 O HOH L 177 −78.108 −65.351 −37.979 1.00 31.57 O ATOM 3157 O HOH L 178 −87.311 −66.886 −52.634 1.00 36.20 O

TABLE 5 Atomic coordinates for CRBN(TBD):Thalidomide (Murine protein) HEADER  ---- XX-XXX-9-   xxxx  COMPND  --- REMARK 3 REMARK 3 REFINEMENT. REMARK 3  PROGRAM  :  REFMAC 5.6.0117 REMARK 3  AUTHORS   : REMARK 3 REMARK 3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3  DATA USED IN REFINEMENT. REMARK 3   RESOLUTION RANGE HIGH (ANGSTROMS) :  1.88 REMARK 3   RESOLUTION RANGE LOW (ANGSTROMS) :  50.00 REMARK 3   DATA CUTOFF        (SIGMA(F)) : NONE REMARK 3   COMPLETENESS FOR RANGE     (%) :  99.94 REMARK 3   NUMBER OF REFLECTIONS :  37584 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3  CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3  FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3  R VALUE   (WORKING + TEST SET) : 0.18197 REMARK 3  R VALUE      (WORKING SET) :  0.17955 REMARK 3  FREE R VALUE :  0.22867 REMARK 3  FREE R VALUE TEST SET SIZE   (%) :  5.0 REMARK 3  FREE R VALUE TEST SET COUNT :  1983 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3  TOTAL NUMBER OF BINS USED :   20 REMARK 3  BIN RESOLUTION RANGE HIGH : 1.882 REMARK 3  BIN RESOLUTION RANGE LOW : 1.931 REMARK 3  REFLECTION IN BIN     (WORKING SET) :  2673 REMARK 3  BIN COMPLETENESS (WORKING+TEST) (%) : 99.96 REMARK 3  BIN R VALUE        (WORKING SET) : 0.272 REMARK 3  BIN FREE R VALUE SET COUNT :   137 REMARK 3  BIN FREE R VALUE : 0.368 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3  ALL ATOMS          :     3576 REMARK 3 REMARK 3 B VALUES. REMARK 3  FROM WILSON PLOT (A**2) : NULL REMARK 3  MEAN B VALUE (OVERALL, A**2) : 29.871 REMARK 3  OVERALL ANISOTROPIC B VALUE. REMARK 3   B11 (A**2) : NULL REMARK 3   B22 (A**2) : NULL REMARK 3   B33 (A**2) : NULL REMARK 3   B12 (A**2) : NULL REMARK 3   B13 (A**2) : NULL REMARK 3   B23 (A**2) : NULL REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3  ESU BASED ON R VALUE   (A):  0.135 REMARK 3  ESU BASED ON FREE R VALUE   (A):  0.135 REMARK 3  ESU BASED ON MAXIMUM LIKELIHOOD   (A):  0.091 REMARK 3  ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2):  3.062 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3  CORRELATION COEFFICIENT FO-FC :  0.963 REMARK 3  CORRELATION COEFFICIENT FO-FC FREE :  0.940 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT  RMS  WEIGHT REMARK 3  BOND LENGTHS REFINED ATOMS (A):  3289 ;  0.014 ;  0.020 REMARK 3  BOND ANGLES REFINED ATOMS (DEGREES):  4483 ;  1.676 ;  1.974 REMARK 3  TORSION ANGLES, PERIOD 1 (DEGREES):   389 ; 17.405 ;  5.000 REMARK 3  TORSION ANGLES, PERIOD 2 (DEGREES):   112 ; 39.373 ; 23.661 REMARK 3  TORSION ANGLES, PERIOD 3 (DEGREES):   544 ; 15.190 ; 15.000 REMARK 3  TORSION ANGLES, PERIOD 4 (DEGREES):    8 ; 19.411 ; 15.000 REMARK 3  CHIRAL-CENTER RESTRAINTS (A**3):   504 ;  0.097 ;  0.200 REMARK 3  GENERAL PLANES REFINED ATOMS (A):  2372 ;  0.018 ;  0.021 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT  RMS  WEIGHT REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3  NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 TWIN DETAILS REMARK 3  NUMBER OF TWIN DOMAINS : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3  NUMBER OF TLS GROUPS : 4 REMARK 3  ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3  TLS GROUP : 1 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS C  SSSEQI   TO C  SSSEQI REMARK 3   RESIDUE RANGE : A     1 A   112 REMARK 3   ORIGIN FOR THE GROUP (A):   0.0000   0.0000   0.0000 REMARK 3   T TENSOR REMARK 3 T11: 0.0000 T22: 0.0000 REMARK 3 T33: 0.0000 T12: 0.0000 REMARK 3 T13: 0.0000 T23: 0.0000 REMARK 3   L TENSOR REMARK 3 L11: 0.0000 L22: 0.0000 REMARK 3 L33: 0.0000 L12: 0.0000 REMARK 3 L13: 0.0000 L23: 0.0000 REMARK 3   S TENSOR REMARK 3 S11: 0.0000 S12: 0.0000 S13: 0.0000 REMARK 3 S21: 0.0000 S22: 0.0000 S23: 0.0000 REMARK 3 S31: 0.0000 S32: 0.0000 S33: 0.0000 REMARK 3 REMARK 3  TLS GROUP : 2 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS C  SSSEQI   TO C  SSSEQI REMARK 3   RESIDUE RANGE : B     1 B   112 REMARK 3   ORIGIN FOR THE GROUP (A):   0.0000   0.0000   0.0000 REMARK 3   T TENSOR REMARK 3 T11: 0.0000 T22: 0.0000 REMARK 3 T33: 0.0000 T12: 0.0000 REMARK 3 T13: 0.0000 T23: 0.0000 REMARK 3   L TENSOR REMARK 3 L11: 0.0000 L22: 0.0000 REMARK 3 L33: 0.0000 L12: 0.0000 REMARK 3 L13: 0.0000 L23: 0.0000 REMARK 3   S TENSOR REMARK 3 S11: 0.0000 S12: 0.0000 S13: 0.0000 REMARK 3 S21: 0.0000 S22: 0.0000 S23: 0.0000 REMARK 3 S31: 0.0000 S32: 0.0000 S33: 0.0000 REMARK 3 REMARK 3  TLS GROUP : 3 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS C  SSSEQI   TO C  SSSEQI REMARK 3   RESIDUE RANGE : C     1 C   112 REMARK 3   ORIGIN FOR THE GROUP (A):   0.0000   0.0000   0.0000 REMARK 3   T TENSOR REMARK 3 T11: 0.0000 T22: 0.0000 REMARK 3 T33: 0.0000 T12: 0.0000 REMARK 3 T13: 0.0000 T23: 0.0000 REMARK 3   L TENSOR REMARK 3 L11: 0.0000 L22: 0.0000 REMARK 3 L33: 0.0000 L12: 0.0000 REMARK 3 L13: 0.0000 L23: 0.0000 REMARK 3   S TENSOR REMARK 3 S11: 0.0000 S12: 0.0000 S13: 0.0000 REMARK 3 S21: 0.0000 S22: 0.0000 S23: 0.0000 REMARK 3 S31: 0.0000 S32: 0.0000 S33: 0.0000 REMARK 3 REMARK 3  TLS GROUP : 4 REMARK 3   NUMBER OF COMPONENTS GROUP : 1 REMARK 3   COMPONENTS C  SSSEQI   TO C  SSSEQI REMARK 3   RESIDUE RANGE : D     1 D   112 REMARK 3   ORIGIN FOR THE GROUP (A):   0.0000   0.0000   0.0000 REMARK 3   T TENSOR REMARK 3 T11: 0.0000 T22: 0.0000 REMARK 3 T33: 0.0000 T12: 0.0000 REMARK 3 T13: 0.0000 T23: 0.0000 REMARK 3   L TENSOR REMARK 3 L11: 0.0000 L22: 0.0000 REMARK 3 L33: 0.0000 L12: 0.0000 REMARK 3 L13: 0.0000 L23: 0.0000 REMARK 3   S TENSOR REMARK 3 S11: 0.0000 S12: 0.0000 S13: 0.0000 REMARK 3 S21: 0.0000 S22: 0.0000 S23: 0.0000 REMARK 3 S31: 0.0000 S32: 0.0000 S33: 0.0000 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3  METHOD USED  :  MASK REMARK 3  PARAMETERS FOR MASK CALCULATION REMARK 3  VDW PROBE RADIUS :  1.20 REMARK 3  ION PROBE RADIUS :  0.80 REMARK 3  SHRINKAGE RADIUS :  0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT REMARK 3 U VALUES   : REFINED INDIVIDUALLY REMARK 3 LINKR SER C 341 VAL C 356 gap LINKR LEU A 342 GLU A 358 gap LINKR MET B 346 GLY B 354 gap LINKR MET B 346 VAL B 356 gap CRYST1 143.146  143.146  143.146  90.00  90.00  90.00 I 2 3 SCALE1   0.006986  0.000000  0.000000  0.00000 SCALE2   0.000000  0.006986  0.000000  0.00000 SCALE3   0.000000  0.000000  0.006986  0.00000 ATOM 1 N SER C 320 17.597 −9.098 −70.900 1.00 54.44 N ATOM 2 CA SER C 320 17.270 −7.667 −70.570 1.00 61.42 C ATOM 3 CB SER C 320 15.980 −7.215 −71.268 1.00 54.67 C ATOM 4 OG SER C 320 14.906 −8.081 −70.964 1.00 67.19 O ATOM 5 C SER C 320 17.182 −7.407 −69.061 1.00 46.80 C ATOM 6 O SER C 320 17.150 −6.249 −68.624 1.00 51.56 O ATOM 7 N THR C 321 17.132 −8.479 −68.270 1.00 48.55 N ATOM 8 CA THR C 321 17.339 −8.355 −66.824 1.00 38.24 C ATOM 9 CB THR C 321 16.324 −9.180 −66.022 1.00 44.93 C ATOM 10 OG1 THR C 321 16.562 −10.576 −66.240 1.00 37.55 O ATOM 11 CG2 THR C 321 14.887 −8.822 −66.433 1.00 51.06 C ATOM 12 C THR C 321 18.766 −8.777 −66.447 1.00 31.37 C ATOM 13 O THR C 321 19.137 −8.744 −65.271 1.00 27.93 O ATOM 14 N SER C 322 19.568 −9.143 −67.451 1.00 24.52 N ATOM 15 CA SER C 322 20.959 −9.608 −67.210 1.00 24.43 C ATOM 16 CB SER C 322 21.514 −10.301 −68.451 1.00 31.13 C ATOM 17 OG SER C 322 21.087 −11.642 −68.509 1.00 43.36 O ATOM 18 C SER C 322 21.900 −8.475 −66.799 1.00 27.14 C ATOM 19 O SER C 322 21.917 −7.418 −67.421 1.00 25.75 O ATOM 20 N LEU C 323 22.672 −8.691 −65.736 1.00 20.00 N ATOM 21 CA LEU C 323 23.754 −7.764 −65.388 1.00 17.36 C ATOM 22 CB LEU C 323 23.652 −7.351 −63.909 1.00 21.16 C ATOM 23 CG LEU C 323 22.389 −6.507 −63.611 1.00 24.94 C ATOM 24 CD1 LEU C 323 22.153 −6.341 −62.123 1.00 28.25 C ATOM 25 CD2 LEU C 323 22.527 −5.149 −64.258 1.00 31.31 C ATOM 26 C LEU C 323 25.045 −8.490 −65.626 1.00 18.00 C ATOM 27 O LEU C 323 25.357 −9.433 −64.909 1.00 17.30 O ATOM 28 N CYS C 324 25.792 −8.081 −66.650 1.00 19.62 N ATOM 29 CA CYS C 324 27.017 −8.804 −67.029 1.00 20.33 C ATOM 30 CB CYS C 324 27.055 −9.000 −68.563 1.00 23.96 C ATOM 31 SG CYS C 324 25.715 −10.038 −69.191 1.00 28.05 S ATOM 32 C CYS C 324 28.301 −8.100 −66.561 1.00 18.86 C ATOM 33 O CYS C 324 28.301 −6.917 −66.268 1.00 20.71 O ATOM 34 N CYS C 325 29.398 −8.860 −66.504 1.00 18.63 N ATOM 35 CA CYS C 325 30.723 −8.304 −66.242 1.00 18.73 C ATOM 36 CB CYS C 325 31.774 −9.415 −66.340 1.00 17.56 C ATOM 37 SG CYS C 325 33.479 −8.819 −66.186 1.00 18.80 S ATOM 38 C CYS C 325 31.004 −7.219 −67.280 1.00 19.89 C ATOM 39 O CYS C 325 30.831 −7.432 −68.486 1.00 19.77 O ATOM 40 N LYS C 326 31.399 −6.047 −66.828 1.00 18.98 N ATOM 41 CA LYS C 326 31.578 −4.935 −67.749 1.00 22.19 C ATOM 42 CB LYS C 326 31.645 −3.624 −66.986 1.00 21.31 C ATOM 43 CG LYS C 326 32.193 −2.468 −67.810 1.00 33.23 C ATOM 44 CD LYS C 326 31.073 −1.555 −68.226 1.00 40.67 C ATOM 45 CE LYS C 326 30.631 −0.711 −67.062 1.00 35.42 C ATOM 46 NZ LYS C 326 31.773 0.079 −66.530 1.00 55.41 N ATOM 47 C LYS C 326 32.862 −5.112 −68.594 1.00 20.48 C ATOM 48 O LYS C 326 32.924 −4.704 −69.777 1.00 22.64 O ATOM 49 N GLN C 327 33.847 −5.728 −67.996 1.00 18.81 N ATOM 50 CA GLN C 327 35.125 −5.942 −68.643 1.00 18.22 C ATOM 51 CB GLN C 327 36.186 −6.383 −67.628 1.00 19.20 C ATOM 52 CG GLN C 327 37.539 −6.701 −68.266 1.00 22.08 C ATOM 53 CD GLN C 327 38.656 −6.854 −67.265 1.00 23.05 C ATOM 54 OE1 GLN C 327 39.629 −7.564 −67.511 1.00 26.41 O ATOM 55 NE2 GLN C 327 38.525 −6.208 −66.140 1.00 19.54 N ATOM 56 C GLN C 327 34.991 −6.956 −69.792 1.00 19.41 C ATOM 57 O GLN C 327 35.380 −6.656 −70.911 1.00 19.39 O ATOM 58 N CYS C 328 34.452 −8.154 −69.511 1.00 18.40 N ATOM 59 CA CYS C 328 34.422 −9.186 −70.546 1.00 19.45 C ATOM 60 CB CYS C 328 34.836 −10.566 −70.005 1.00 20.93 C ATOM 61 SG CYS C 328 33.592 −11.299 −68.890 1.00 21.47 S ATOM 62 C CYS C 328 33.102 −9.223 −71.267 1.00 18.26 C ATOM 63 O CYS C 328 32.943 −9.979 −72.236 1.00 20.79 O ATOM 64 N GLN C 329 32.143 −8.388 −70.815 1.00 19.25 N ATOM 65 CA GLN C 329 30.858 −8.167 −71.519 1.00 23.13 C ATOM 66 CB GLN C 329 31.082 −7.600 −72.927 1.00 23.28 C ATOM 67 CG GLN C 329 32.155 −6.509 −72.959 1.00 25.65 C ATOM 68 CD GLN C 329 32.065 −5.642 −74.179 1.00 30.51 C ATOM 69 OE1 GLN C 329 31.866 −4.445 −74.069 1.00 28.81 O ATOM 70 NE2 GLN C 329 32.215 −6.245 −75.366 1.00 25.71 N ATOM 71 C GLN C 329 29.874 −9.345 −71.606 1.00 26.68 C ATOM 72 O GLN C 329 28.663 −9.143 −71.460 1.00 27.94 O ATOM 73 N GLU C 330 30.376 −10.544 −71.900 1.00 24.20 N ATOM 74 CA GLU C 330 29.505 −11.670 −72.247 1.00 26.72 C ATOM 75 CB GLU C 330 30.189 −12.594 −73.249 1.00 27.74 C ATOM 76 CG GLU C 330 30.699 −11.899 −74.513 1.00 34.59 C ATOM 77 CD GLU C 330 29.593 −11.220 −75.293 1.00 45.62 C ATOM 78 OE1 GLU C 330 28.599 −11.894 −75.604 1.00 49.20 O ATOM 79 OE2 GLU C 330 29.720 −10.005 −75.600 1.00 62.00 O ATOM 80 C GLU C 330 29.095 −12.496 −71.007 1.00 32.53 C ATOM 81 O GLU C 330 28.172 −13.296 −71.073 1.00 26.39 O ATOM 82 N THR C 331 29.807 −12.308 −69.894 1.00 22.19 N ATOM 83 CA THR C 331 29.644 −13.175 −68.743 1.00 21.66 C ATOM 84 CB THR C 331 30.979 −13.320 −67.995 1.00 20.37 C ATOM 85 OG1 THR C 331 31.978 −13.822 −68.895 1.00 21.34 O ATOM 86 CG2 THR C 331 30.846 −14.283 −66.759 1.00 20.48 C ATOM 87 C THR C 331 28.570 −12.579 −67.802 1.00 21.67 C ATOM 88 O THR C 331 28.771 −11.510 −67.234 1.00 20.43 O ATOM 89 N GLU C 332 27.444 −13.288 −67.620 1.00 20.52 N ATOM 90 CA GLU C 332 26.369 −12.778 −66.724 1.00 20.77 C ATOM 91 CB GLU C 332 25.017 −13.480 −66.977 1.00 20.27 C ATOM 92 CG GLU C 332 23.882 −12.937 −66.124 1.00 19.05 C ATOM 93 CD GLU C 332 22.596 −13.725 −66.305 1.00 20.91 C ATOM 94 OE1 GLU C 332 21.899 −13.477 −67.285 1.00 23.36 O ATOM 95 OE2 GLU C 332 22.317 −14.608 −65.483 1.00 26.39 O ATOM 96 C GLU C 332 26.792 −13.004 −65.276 1.00 18.32 C ATOM 97 O GLU C 332 27.275 −14.091 −64.925 1.00 21.92 O ATOM 98 N ILE C 333 26.635 −11.980 −64.448 1.00 16.21 N ATOM 99 CA ILE C 333 27.008 −12.108 −63.025 1.00 15.97 C ATOM 100 CB ILE C 333 27.890 −10.936 −62.553 1.00 16.96 C ATOM 101 CG1 ILE C 333 29.195 −10.858 −63.404 1.00 17.65 C ATOM 102 CD1 ILE C 333 30.082 −12.105 −63.306 1.00 20.60 C ATOM 103 CG2 ILE C 333 28.207 −11.071 −61.046 1.00 16.94 C ATOM 104 C ILE C 333 25.758 −12.235 −62.118 1.00 16.60 C ATOM 105 O ILE C 333 25.751 −12.999 −61.159 1.00 17.83 O ATOM 106 N THR C 334 24.737 −11.468 −62.420 1.00 16.91 N ATOM 107 CA THR C 334 23.470 −11.584 −61.701 1.00 19.13 C ATOM 108 CB THR C 334 23.504 −10.825 −60.327 1.00 22.14 C ATOM 109 OG1 THR C 334 22.406 −11.259 −59.500 1.00 18.82 O ATOM 110 CG2 THR C 334 23.436 −9.298 −60.521 1.00 17.18 C ATOM 111 C THR C 334 22.333 −11.118 −62.609 1.00 20.17 C ATOM 112 O THR C 334 22.562 −10.830 −63.794 1.00 19.33 O ATOM 113 N THR C 335 21.104 −11.106 −62.090 1.00 17.83 N ATOM 114 CA THR C 335 19.993 −10.526 −62.812 1.00 17.87 C ATOM 115 CB THR C 335 18.938 −11.589 −63.235 1.00 19.93 C ATOM 116 OG1 THR C 335 18.197 −12.018 −62.079 1.00 21.12 O ATOM 117 CG2 THR C 335 19.607 −12.791 −63.907 1.00 19.48 C ATOM 118 C THR C 335 19.309 −9.526 −61.932 1.00 16.53 C ATOM 119 O THR C 335 19.430 −9.567 −60.705 1.00 17.74 O ATOM 120 N LYS C 336 18.515 −8.670 −62.545 1.00 19.33 N ATOM 121 CA LYS C 336 17.754 −7.693 −61.794 1.00 20.73 C ATOM 122 CB LYS C 336 17.016 −6.767 −62.746 1.00 26.49 C ATOM 123 CG LYS C 336 17.923 −5.803 −63.493 1.00 38.49 C ATOM 124 CD LYS C 336 17.092 −4.813 −64.303 1.00 40.78 C ATOM 125 CE LYS C 336 17.974 −3.943 −65.188 1.00 52.95 C ATOM 126 NZ LYS C 336 17.150 −3.107 −66.113 1.00 44.22 N ATOM 127 C LYS C 336 16.748 −8.362 −60.884 1.00 22.29 C ATOM 128 O LYS C 336 16.337 −7.776 −59.892 1.00 18.74 O ATOM 129 N ASN C 337 16.311 −9.572 −61.246 1.00 18.70 N ATOM 130 CA ASN C 337 15.382 −10.329 −60.372 1.00 20.84 C ATOM 131 CB ASN C 337 14.928 −11.661 −61.030 1.00 19.37 C ATOM 132 C3 ASN C 337 14.181 −11.439 −62.324 1.00 28.00 C ATOM 133 OD1 ASN C 337 14.574 −11.945 −63.371 1.00 28.85 O ATOM 134 ND2 ASN C 337 13.139 −10.631 −62.272 1.00 36.13 N ATOM 135 C ASN C 337 15.945 −10.629 −59.001 1.00 19.79 C ATOM 136 O ASN C 337 15.183 −10.888 −58.074 1.00 20.01 O ATOM 137 N GLU C 338 17.275 −10.604 −58.860 1.00 16.75 N ATOM 138 CA GLU C 338 17.931 −11.039 −57.580 1.00 17.47 C ATOM 139 CB GLU C 338 19.243 −11.808 −57.841 1.00 17.88 C ATOM 140 CG GLU C 338 19.078 −13.098 −58.632 1.00 21.61 C ATOM 141 CD GLU C 338 18.037 −14.040 −58.027 1.00 22.61 C ATOM 142 OE1 GLU C 338 18.033 −14.253 −56.784 1.00 22.22 O ATOM 143 OE2 GLU C 338 17.225 −14.574 −58.808 1.00 32.25 O ATOM 144 C GLU C 338 18.184 −9.879 −56.592 1.00 15.17 C ATOM 145 O GLU C 338 18.589 −10.095 −55.433 1.00 16.49 O ATOM 146 N ILE C 339 17.889 −8.669 −57.041 1.00 16.22 N ATOM 147 CA ILE C 339 18.150 −7.464 −56.253 1.00 16.63 C ATOM 148 CB ILE C 339 17.934 −6.180 −57.111 1.00 17.56 C ATOM 149 CG1 ILE C 339 18.984 −6.123 −58.230 1.00 21.04 C ATOM 150 CD1 ILE C 339 18.666 −5.066 −59.289 1.00 21.66 C ATOM 151 CG2 ILE C 339 17.980 −4.921 −56.237 1.00 20.81 C ATOM 152 C ILE C 339 17.249 −7.414 −55.015 1.00 20.59 C ATOM 153 O ILE C 339 16.028 −7.720 −55.082 1.00 18.80 O ATOM 154 N PHE C 340 17.842 −7.039 −53.890 1.00 19.91 N ATOM 155 CA PHE C 340 17.051 −6.776 −52.697 1.00 20.71 C ATOM 156 CB PHE C 340 16.912 −8.057 −51.844 1.00 16.57 C ATOM 157 CG PHE C 340 18.137 −8.399 −51.056 1.00 17.66 C ATOM 158 CD2 PHE C 340 18.183 −8.159 −49.688 1.00 16.76 C ATOM 159 CE2 PHE C 340 19.317 −8.437 −48.951 1.00 18.55 C ATOM 160 CZ PHE C 340 20.425 −9.028 −49.565 1.00 18.92 C ATOM 161 CE1 PHE C 340 20.392 −9.302 −50.932 1.00 16.51 C ATOM 162 CD1 PHE C 340 19.260 −9.006 −51.677 1.00 15.31 C ATOM 163 C PHE C 340 17.658 −5.664 −51.870 1.00 22.75 C ATOM 164 O PHE C 340 18.821 −5.284 −52.070 1.00 19.45 O ATOM 165 N SER C 341 16.896 −5.210 −50.879 1.00 22.32 N ATOM 166 CA SER C 341 17.342 −4.112 −50.030 1.00 28.31 C ATOM 167 CB SER C 341 16.282 −3.011 −49.993 1.00 30.08 C ATOM 168 OG SER C 341 16.663 −2.008 −49.060 1.00 42.42 O ATOM 169 C SER C 341 17.686 −4.575 −48.617 1.00 24.33 C ATOM 170 O SER C 341 16.802 −4.956 −47.836 1.00 25.15 O ATOM 171 N LEU C 342 18.965 −4.528 −48.271 1.00 25.48 N ATOM 172 CA LEU C 342 19.360 −4.873 −46.909 1.00 29.14 C ATOM 173 CB LEU C 342 20.764 −5.472 −46.873 1.00 32.26 C ATOM 174 CG LEU C 342 21.197 −6.085 −45.533 1.00 35.08 C ATOM 175 CD1 LEU C 342 20.476 −7.401 −45.263 1.00 38.20 C ATOM 176 CD2 LEU C 342 22.691 −6.314 −45.519 1.00 37.13 C ATOM 177 C LEU C 342 19.233 −3.674 −45.954 1.00 37.44 C ATOM 178 O LEU C 342 19.712 −2.569 −46.247 1.00 36.54 O ATOM 179 N SER C 343 18.544 −3.906 −44.836 1.00 29.22 N ATOM 180 CA SER C 343 18.332 −2.918 −43.753 1.00 42.84 C ATOM 181 CB SER C 343 19.636 −2.274 −43.297 1.00 39.94 C ATOM 182 OG SER C 343 20.300 −3.169 −42.452 1.00 45.11 O ATOM 183 C SER C 343 17.270 −1.885 −44.047 1.00 53.89 C ATOM 184 O SER C 343 16.134 −2.030 −43.595 1.00 46.67 O ATOM 185 N VAL C 358 25.784 3.683 −50.724 1.00 86.16 N ATOM 186 CA VAL C 358 25.429 2.329 −51.159 1.00 91.37 C ATOM 187 CB VAL C 358 24.913 1.439 −49.993 1.00 90.88 C ATOM 188 CG1 VAL C 358 25.871 0.281 −49.740 1.00 77.39 C ATOM 189 CG2 VAL C 358 24.695 2.258 −48.726 1.00 88.00 C ATOM 190 C VAL C 358 24.430 2.322 −52.323 1.00 92.23 C ATOM 191 O VAL C 358 23.639 1.391 −52.473 1.00 95.73 O ATOM 192 N HIS C 359 24.462 3.384 −53.123 1.00 89.82 N ATOM 193 CA HIS C 359 24.024 3.324 −54.512 1.00 79.39 C ATOM 194 CB HIS C 359 23.828 4.738 −55.047 1.00 91.89 C ATOM 195 CG HIS C 359 22.714 4.866 −56.059 1.00 100.08 C ATOM 196 ND1 HIS C 359 21.653 5.680 −55.870 1.00 109.22 N ATOM 197 CE1 HIS C 359 20.831 5.598 −56.933 1.00 105.11 C ATOM 198 NE2 HIS C 359 21.367 4.735 −57.810 1.00 106.55 N ATOM 199 CD2 HIS C 359 22.530 4.267 −57.306 1.00 99.77 C ATOM 200 C HIS C 359 25.134 2.643 −55.267 1.00 69.78 C ATOM 201 O HIS C 359 24.899 1.850 −56.185 1.00 72.62 O ATOM 202 N GLU C 360 26.361 2.947 −54.844 1.00 68.81 N ATOM 203 CA GLU C 360 27.590 2.275 −55.284 1.00 62.20 C ATOM 204 CB GLU C 360 28.717 2.551 −54.273 1.00 69.01 C ATOM 205 CG GLU C 360 29.032 4.018 −54.034 1.00 102.39 C ATOM 206 CD GLU C 360 30.397 4.406 −54.560 1.00 110.02 C ATOM 207 OE1 GLU C 360 31.240 4.851 −53.750 1.00 115.50 O ATOM 208 OE2 GLU C 360 30.635 4.245 −55.778 1.00 108.55 O ATOM 209 C GLU C 360 27.448 0.758 −55.410 1.00 56.41 C ATOM 210 O GLU C 360 28.046 0.139 −56.305 1.00 33.37 O ATOM 211 N THR C 361 26.726 0.159 −54.462 1.00 43.79 N ATOM 212 CA THR C 361 26.789 −1.289 −54.248 1.00 36.57 C ATOM 213 CB THR C 361 27.462 −1.640 −52.898 1.00 43.48 C ATOM 214 OG1 THR C 361 28.765 −1.043 −52.847 1.00 55.08 O ATOM 215 CG2 THR C 361 27.618 −3.165 −52.747 1.00 34.71 C ATOM 216 C THR C 361 25.399 −1.933 −54.364 1.00 31.72 C ATOM 217 O THR C 361 24.476 −1.584 −53.642 1.00 34.30 O ATOM 218 N LEU C 362 25.265 −2.841 −55.323 1.00 28.72 N ATOM 219 CA LEU C 362 24.049 −3.581 −55.523 1.00 24.86 C ATOM 220 CB LEU C 362 23.982 −4.026 −56.977 1.00 24.76 C ATOM 221 CG LEU C 362 22.644 −4.428 −57.549 1.00 32.95 C ATOM 222 CD1 LEU C 362 21.670 −3.242 −57.520 1.00 33.14 C ATOM 223 CD2 LEU C 362 22.865 −4.898 −58.973 1.00 32.38 C ATOM 224 C LEU C 362 24.098 −4.811 −54.623 1.00 26.07 C ATOM 225 O LEU C 362 25.104 −5.510 −54.592 1.00 24.45 O ATOM 226 N THR C 363 23.012 −5.101 −53.918 1.00 18.38 N ATOM 227 CA THR C 363 22.984 −6.329 −53.107 1.00 16.32 C ATOM 228 CB THR C 363 22.617 −6.056 −51.638 1.00 21.09 C ATOM 229 OG1 THR C 363 21.375 −5.358 −51.571 1.00 20.47 O ATOM 230 CG2 THR C 363 23.731 −5.225 −50.935 1.00 20.12 C ATOM 231 C THR C 363 21.989 −7.273 −53.742 1.00 18.41 C ATOM 232 O THR C 363 20.849 −6.887 −54.023 1.00 18.88 O ATOM 233 N VAL C 364 22.440 −8.489 −54.035 1.00 14.94 N ATOM 234 CA VAL C 364 21.594 −9.473 −54.727 1.00 13.40 C ATOM 235 CB VAL C 364 22.039 −9.701 −56.200 1.00 12.25 C ATOM 236 CG1 VAL C 364 21.771 −8.460 −57.071 1.00 17.35 C ATOM 237 CG2 VAL C 364 23.527 −10.107 −56.248 1.00 15.31 C ATOM 238 C VAL C 364 21.667 −10.818 −53.966 1.00 13.21 C ATOM 239 O VAL C 364 22.674 −11.136 −53.326 1.00 13.05 O ATOM 240 N TYR C 365 20.569 −11.587 −53.992 1.00 17.09 N ATOM 241 CA TYR C 365 20.549 −12.854 −53.259 1.00 15.55 C ATOM 242 CB TYR C 365 19.133 −13.392 −53.241 1.00 16.73 C ATOM 243 CG TYR C 365 18.200 −12.661 −52.307 1.00 15.97 C ATOM 244 CD1 TYR C 365 18.424 −12.659 −50.927 1.00 15.06 C ATOM 245 CE1 TYR C 365 17.539 −12.050 −50.061 1.00 15.79 C ATOM 246 CZ TYR C 365 16.403 −11.438 −50.557 1.00 17.61 C ATOM 247 OH TYR C 365 15.513 −10.830 −49.665 1.00 18.59 O ATOM 248 CE2 TYR C 365 16.137 −11.429 −51.929 1.00 17.31 C ATOM 249 CD2 TYR C 365 17.027 −12.059 −52.796 1.00 16.54 C ATOM 250 C TYR C 365 21.453 −13.919 −53.918 1.00 16.38 C ATOM 251 O TYR C 365 21.998 −14.797 −53.245 1.00 15.40 O ATOM 252 N LYS C 366 21.556 −13.849 −55.243 1.00 14.22 N ATOM 253 CA LYS C 366 22.203 −14.903 −56.022 1.00 14.39 C ATOM 254 CB LYS C 366 21.146 −15.801 −56.695 1.00 15.32 C ATOM 255 CG LYS C 366 20.304 −16.680 −55.738 1.00 18.29 C ATOM 256 CD LYS C 366 21.231 −17.638 −55.023 1.00 21.75 C ATOM 257 CE LYS C 366 20.706 −19.036 −54.851 1.00 32.92 C ATOM 258 NZ LYS C 366 21.855 −19.979 −54.530 1.00 22.76 N ATOM 259 C LYS C 366 23.059 −14.264 −57.109 1.00 15.89 C ATOM 260 O LYS C 366 22.677 −13.232 −57.686 1.00 17.96 O ATOM 261 N ALA C 367 24.133 −14.953 −57.468 1.00 15.52 N ATOM 262 CA ALA C 367 25.041 −14.500 −58.553 1.00 17.29 C ATOM 263 CB ALA C 367 26.087 −13.531 −58.005 1.00 17.16 C ATOM 264 C ALA C 367 25.711 −15.734 −59.164 1.00 16.23 C ATOM 265 O ALA C 367 25.606 −16.850 −58.615 1.00 18.42 O ATOM 266 N SER C 368 26.327 −15.550 −60.322 1.00 18.54 N ATOM 267 CA SER C 368 26.842 −16.652 −61.125 1.00 18.67 C ATOM 268 CB SER C 368 25.883 −16.938 −62.301 1.00 16.89 C ATOM 269 OG SER C 368 25.588 −15.770 −63.080 1.00 24.00 O ATOM 270 C SER C 368 28.198 −16.282 −61.677 1.00 18.19 C ATOM 271 O SER C 368 28.477 −15.087 −61.908 1.00 14.64 O ATOM 272 N ASN C 369 29.026 −17.292 −61.941 1.00 16.45 N ATOM 273 CA ASN C 369 30.264 −17.077 −62.739 1.00 18.06 C ATOM 274 CB ASN C 369 29.941 −16.415 −64.128 1.00 17.86 C ATOM 275 CG ASN C 369 28.926 −17.219 −64.958 1.00 21.13 C ATOM 276 OD1 ASN C 369 27.973 −16.655 −65.522 1.00 24.07 O ATOM 277 ND2 ASN C 369 29.090 −18.518 −64.986 1.00 20.73 N ATOM 278 C ASN C 369 31.285 −16.224 −61.979 1.00 20.08 C ATOM 279 O ASN C 369 32.055 −15.496 −62.589 1.00 20.43 O ATOM 280 N LEU C 370 31.249 −16.294 −60.640 1.00 19.32 N ATOM 281 CA LEU C 370 32.252 −15.649 −59.789 1.00 16.66 C ATOM 282 CB LEU C 370 31.567 −14.766 −58.707 1.00 15.97 C ATOM 283 CG LEU C 370 30.788 −13.562 −59.246 1.00 17.67 C ATOM 284 CD1 LEU C 370 29.921 −12.945 −58.139 1.00 17.82 C ATOM 285 CD2 LEU C 370 31.765 −12.493 −59.774 1.00 17.13 C ATOM 286 C LEU C 370 33.134 −16.684 −59.124 1.00 22.04 C ATOM 287 O LEU C 370 32.664 −17.765 −58.750 1.00 27.66 O ATOM 288 N ASN C 371 34.425 −16.359 −59.011 1.00 19.95 N ATOM 289 CA ASN C 371 35.391 −17.098 −58.191 1.00 22.48 C ATOM 290 CB ASN C 371 36.744 −17.219 −58.942 1.00 23.38 C ATOM 291 CG ASN C 371 36.716 −18.257 −60.034 1.00 34.72 C ATOM 292 OD1 ASN C 371 35.928 −19.200 −59.992 1.00 40.19 O ATOM 293 ND2 ASN C 371 37.580 −18.090 −61.027 1.00 29.69 N ATOM 294 C ASN C 371 35.646 −16.343 −56.871 1.00 21.29 C ATOM 295 O ASN C 371 35.836 −15.137 −56.872 1.00 24.39 O ATOM 296 N LEU C 372 35.690 −17.079 −55.765 1.00 24.84 N ATOM 297 CA LEU C 372 35.943 −16.502 −54.464 1.00 25.98 C ATOM 298 CB LEU C 372 35.178 −17.273 −53.371 1.00 28.82 C ATOM 299 CG LEU C 372 33.653 −17.377 −53.543 1.00 29.97 C ATOM 300 CD1 LEU C 372 33.015 −18.146 −52.385 1.00 28.60 C ATOM 301 CD2 LEU C 372 33.042 −15.996 −53.667 1.00 22.27 C ATOM 302 C LEU C 372 37.432 −16.552 −54.183 1.00 31.79 C ATOM 303 O LEU C 372 38.061 −17.570 −54.391 1.00 29.23 O ATOM 304 N ILE C 373 37.977 −15.430 −53.714 1.00 28.88 N ATOM 305 CA ILE C 373 39.404 −15.305 −53.392 1.00 28.43 C ATOM 306 CB ILE C 373 39.999 −14.023 −54.008 1.00 30.57 C ATOM 307 CG1 ILE C 373 39.787 −13.997 −55.519 1.00 34.72 C ATOM 308 CD1 ILE C 373 40.451 −15.155 −56.247 1.00 35.61 C ATOM 309 CG2 ILE C 373 41.483 −13.878 −53.643 1.00 35.44 C ATOM 310 C ILE C 373 39.549 −15.196 −51.891 1.00 32.83 C ATOM 311 O ILE C 373 38.996 −14.273 −51.282 1.00 26.95 O ATOM 312 N GLY C 374 40.282 −16.128 −51.285 1.00 38.01 N ATOM 313 CA GLY C 374 40.625 −16.018 −49.858 1.00 37.48 C ATOM 314 C GLY C 374 39.531 −16.492 −48.926 1.00 43.62 C ATOM 315 O GLY C 374 38.617 −17.227 −49.338 1.00 39.66 O ATOM 316 N ARG C 375 39.619 −16.053 −47.668 1.00 39.28 N ATOM 317 CA ARG C 375 38.692 −16.453 −46.607 1.00 40.63 C ATOM 318 CB ARG C 375 39.469 −17.059 −45.436 1.00 47.66 C ATOM 319 CG ARG C 375 40.051 −18.435 −45.710 1.00 60.28 C ATOM 320 CD ARG C 375 41.210 −18.749 −44.766 1.00 70.29 C ATOM 321 NE ARG C 375 40.897 −18.438 −43.368 1.00 91.51 N ATOM 322 CZ ARG C 375 41.534 −17.523 −42.633 1.00 89.00 C ATOM 323 NH1 ARG C 375 42.540 −16.826 −43.148 1.00 90.40 N ATOM 324 NH2 ARG C 375 41.168 −17.313 −41.376 1.00 89.65 N ATOM 325 C ARG C 375 37.904 −15.232 −46.123 1.00 26.99 C ATOM 326 O ARG C 375 38.380 −14.111 −46.263 1.00 34.28 O ATOM 327 N PRO C 376 36.697 −15.443 −45.538 1.00 29.33 N ATOM 328 CA PRO C 376 35.893 −14.276 −45.127 1.00 28.39 C ATOM 329 CB PRO C 376 34.609 −14.908 −44.560 1.00 28.84 C ATOM 330 CG PRO C 376 34.587 −16.316 −45.096 1.00 34.04 C ATOM 331 CD PRO C 376 36.028 −16.712 −45.195 1.00 30.00 C ATOM 332 C PRO C 376 36.588 −13.448 −44.039 1.00 39.15 C ATOM 333 O PRO C 376 37.254 −14.015 −43.153 1.00 35.18 O ATOM 334 N SER C 377 36.392 −12.132 −44.085 1.00 27.68 N ATOM 335 CA SER C 377 36.922 −11.223 −43.075 1.00 26.47 C ATOM 336 CB SER C 377 38.149 −10.498 −43.632 1.00 31.82 C ATOM 337 OG SER C 377 38.432 −9.324 −42.893 1.00 29.34 O ATOM 338 C SER C 377 35.846 −10.217 −42.671 1.00 27.05 C ATOM 339 O SER C 377 35.015 −9.838 −43.481 1.00 23.93 O ATOM 340 N THR C 378 35.838 −9.794 −41.413 1.00 21.03 N ATOM 341 CA THR C 378 34.877 −8.768 −40.993 1.00 19.97 C ATOM 342 CB THR C 378 34.255 −9.084 −39.619 1.00 24.98 C ATOM 343 OG1 THR C 378 35.301 −9.216 −38.657 1.00 25.97 O ATOM 344 CG2 THR C 378 33.455 −10.394 −39.664 1.00 26.12 C ATOM 345 C THR C 378 35.522 −7.347 −40.947 1.00 20.90 C ATOM 346 O THR C 378 34.844 −6.346 −40.646 1.00 23.19 O ATOM 347 N VAL C 379 36.802 −7.268 −41.292 1.00 29.55 N ATOM 348 CA VAL C 379 37.517 −5.988 −41.266 1.00 27.57 C ATOM 349 CB VAL C 379 39.010 −6.147 −41.685 1.00 32.26 C ATOM 350 CG1 VAL C 379 39.740 −4.814 −41.552 1.00 37.63 C ATOM 351 CG2 VAL C 379 39.706 −7.210 −40.844 1.00 35.13 C ATOM 352 C VAL C 379 36.824 −4.956 −42.155 1.00 27.11 C ATOM 353 O VAL C 379 36.672 −5.165 −43.368 1.00 23.80 O ATOM 354 N HIS C 380 36.368 −3.856 −41.539 1.00 19.68 N ATOM 355 CA HIS C 380 35.716 −2.773 −42.249 1.00 22.71 C ATOM 356 CB HIS C 380 36.652 −2.168 −43.325 1.00 29.21 C ATOM 357 CG HIS C 380 37.922 −1.579 −42.772 1.00 30.06 C ATOM 358 ND1 HIS C 380 37.925 −0.644 −41.798 1.00 33.02 N ATOM 359 CE1 HIS C 380 39.192 −0.300 −41.520 1.00 28.04 C ATOM 360 NE2 HIS C 380 39.997 −0.992 −42.334 1.00 36.34 N ATOM 361 CD2 HIS C 380 39.243 −1.766 −43.141 1.00 30.10 C ATOM 362 C HIS C 380 34.429 −3.177 −42.933 1.00 25.03 C ATOM 363 O HIS C 380 33.987 −2.498 −43.851 1.00 19.83 O ATOM 364 N SER C 381 33.798 −4.256 −42.493 1.00 23.92 N ATOM 365 CA SER C 381 32.653 −4.749 −43.248 1.00 22.02 C ATOM 366 CB SER C 381 32.065 −5.998 −42.606 1.00 22.11 C ATOM 367 OG SER C 381 30.857 −6.314 −43.291 1.00 22.36 O ATOM 368 C SER C 381 31.584 −3.685 −43.347 1.00 22.58 C ATOM 369 O SER C 381 31.201 −3.081 −42.334 1.00 23.86 O ATOM 370 N TRP C 382 31.083 −3.449 −44.559 1.00 18.69 N ATOM 371 CA TRP C 382 30.009 −2.480 −44.769 1.00 19.17 C ATOM 372 CB TRP C 382 29.876 −2.136 −46.253 1.00 23.55 C ATOM 373 CG TRP C 382 31.160 −1.629 −46.861 1.00 25.91 C ATOM 374 CD1 TRP C 382 32.104 −0.768 −46.268 1.00 28.49 C ATOM 375 NE1 TRP C 382 33.156 −0.510 −47.148 1.00 20.57 N ATOM 376 CE2 TRP C 382 32.935 −1.147 −48.347 1.00 23.75 C ATOM 377 CD2 TRP C 382 31.658 −1.874 −48.229 1.00 22.75 C ATOM 378 CE3 TRP C 382 31.214 −2.641 −49.311 1.00 21.62 C ATOM 379 CZ3 TRP C 382 31.991 −2.647 −50.503 1.00 23.46 C ATOM 380 CH2 TRP C 382 33.210 −1.940 −50.592 1.00 24.17 C ATOM 381 CZ2 TRP C 382 33.699 −1.167 −49.523 1.00 23.73 C ATOM 382 C TRP C 382 28.674 −2.913 −44.243 1.00 22.73 C ATOM 383 O TRP C 382 27.775 −2.108 −44.108 1.00 22.47 O ATOM 384 N PHE C 383 28.513 −4.203 −43.991 1.00 21.47 N ATOM 385 CA PHE C 383 27.224 −4.722 −43.511 1.00 21.44 C ATOM 386 CB PHE C 383 26.616 −5.670 −44.561 1.00 21.53 C ATOM 387 CG PHE C 383 26.430 −5.024 −45.903 1.00 20.41 C ATOM 388 CD1 PHE C 383 25.357 −4.169 −46.138 1.00 24.94 C ATOM 389 CE1 PHE C 383 25.181 −3.573 −47.384 1.00 25.58 C ATOM 390 CZ PHE C 383 26.100 −3.811 −48.407 1.00 20.60 C ATOM 391 CE2 PHE C 383 27.182 −4.657 −48.181 1.00 20.71 C ATOM 392 CD2 PHE C 383 27.346 −5.254 −46.935 1.00 19.68 C ATOM 393 C PHE C 383 27.450 −5.425 −42.208 1.00 21.12 C ATOM 394 O PHE C 383 27.885 −6.565 −42.187 1.00 19.43 O ATOM 395 N PRO C 384 27.242 −4.707 −41.095 1.00 25.20 N ATOM 396 CA PRO C 384 27.595 −5.237 −39.769 1.00 28.08 C ATOM 397 CB PRO C 384 26.990 −4.197 −38.809 1.00 35.10 C ATOM 398 CG PRO C 384 26.923 −2.935 −39.614 1.00 41.19 C ATOM 399 CD PRO C 384 26.607 −3.376 −41.018 1.00 30.91 C ATOM 400 C PRO C 384 26.944 −6.607 −39.545 1.00 23.83 C ATOM 401 O PRO C 384 25.768 −6.785 −39.883 1.00 23.90 O ATOM 402 N GLY C 385 27.713 −7.570 −39.040 1.00 22.22 N ATOM 403 CA GLY C 385 27.192 −8.907 −38.812 1.00 22.64 C ATOM 404 C GLY C 385 27.518 −9.836 −39.961 1.00 23.19 C ATOM 405 O GLY C 385 27.335 −11.049 −39.859 1.00 26.77 O ATOM 406 N TYR C 386 28.014 −9.275 −41.065 1.00 22.07 N ATOM 407 CA TYR C 386 28.491 −10.109 −42.188 1.00 19.16 C ATOM 408 CB TYR C 386 27.788 −9.715 −43.503 1.00 19.95 C ATOM 409 CG TYR C 386 26.316 −10.026 −43.551 1.00 18.86 C ATOM 410 CD1 TYR C 386 25.849 −11.262 −44.073 1.00 21.60 C ATOM 411 CE1 TYR C 386 24.483 −11.557 −44.116 1.00 18.03 C ATOM 412 CZ TYR C 386 23.562 −10.591 −43.669 1.00 18.64 C ATOM 413 OH TYR C 386 22.189 −10.834 −43.729 1.00 20.48 O ATOM 414 CE2 TYR C 386 24.008 −9.363 −43.186 1.00 22.90 C ATOM 415 CD2 TYR C 386 25.384 −9.087 −43.148 1.00 18.77 C ATOM 416 C TYR C 386 29.987 −9.937 −42.376 1.00 22.75 C ATOM 417 O TYR C 386 30.534 −8.832 −42.120 1.00 20.44 O ATOM 418 N ALA C 387 30.631 −11.018 −42.826 1.00 20.30 N ATOM 419 CA ALA C 387 32.013 −11.008 −43.301 1.00 22.78 C ATOM 420 CB ALA C 387 32.757 −12.240 −42.796 1.00 25.12 C ATOM 421 C ALA C 387 31.996 −11.010 −44.815 1.00 29.58 C ATOM 422 O ALA C 387 31.002 −11.440 −45.425 1.00 23.99 O ATOM 423 N TRP C 388 33.090 −10.539 −45.423 1.00 23.42 N ATOM 424 CA TRP C 388 33.192 −10.455 −46.895 1.00 22.06 C ATOM 425 CB TRP C 388 33.402 −9.008 −47.348 1.00 22.97 C ATOM 426 CG TRP C 388 34.554 −8.327 −46.667 1.00 23.36 C ATOM 427 CD1 TRP C 388 34.505 −7.526 −45.536 1.00 23.59 C ATOM 428 NE1 TRP C 388 35.762 −7.056 −45.222 1.00 23.73 N ATOM 429 CE2 TRP C 388 36.685 −7.570 −46.067 1.00 25.57 C ATOM 430 CD2 TRP C 388 35.966 −8.374 −47.050 1.00 19.60 C ATOM 431 CE3 TRP C 388 36.676 −8.986 −48.064 1.00 24.93 C ATOM 432 CZ3 TRP C 388 38.067 −8.805 −48.117 1.00 31.33 C ATOM 433 CH2 TRP C 388 38.740 −8.008 −47.167 1.00 25.05 C ATOM 434 CZ2 TRP C 388 38.058 −7.388 −46.126 1.00 24.37 C ATOM 435 C TRP C 388 34.292 −11.325 −47.431 1.00 23.80 C ATOM 436 O TRP C 388 35.247 −11.622 −46.739 1.00 22.67 O ATOM 437 N THR C 389 34.131 −11.761 −48.674 1.00 22.64 N ATOM 438 CA THR C 389 35.137 −12.527 −49.390 1.00 23.15 C ATOM 439 CB THR C 389 34.732 −14.019 −49.489 1.00 28.55 C ATOM 440 OG1 THR C 389 34.575 −14.589 −48.166 1.00 25.21 O ATOM 441 CG2 THR C 389 35.759 −14.822 −50.287 1.00 23.81 C ATOM 442 C THR C 389 35.160 −11.927 −50.797 1.00 23.75 C ATOM 443 O THR C 389 34.104 −11.714 −51.398 1.00 22.93 O ATOM 444 N ILE C 390 36.348 −11.611 −51.310 1.00 22.61 N ATOM 445 CA ILE C 390 36.446 −11.025 −52.649 1.00 20.60 C ATOM 446 CB ILE C 390 37.918 −10.671 −53.009 1.00 23.72 C ATOM 447 CG1 ILE C 390 38.433 −9.540 −52.085 1.00 25.88 C ATOM 448 CD1 ILE C 390 39.952 −9.430 −52.036 1.00 30.43 C ATOM 449 CG2 ILE C 390 38.018 −10.266 −54.482 1.00 23.92 C ATOM 450 C ILE C 390 35.880 −11.956 −53.703 1.00 17.74 C ATOM 451 O ILE C 390 36.131 −13.151 −53.661 1.00 19.14 O ATOM 452 N ALA C 391 35.110 −11.401 −54.643 1.00 19.74 N ATOM 453 CA ALA C 391 34.482 −12.190 −55.733 1.00 21.05 C ATOM 454 CB ALA C 391 32.972 −12.198 −55.600 1.00 19.87 C ATOM 455 C ALA C 391 34.863 −11.593 −57.066 1.00 21.71 C ATOM 456 O ALA C 391 34.534 −10.431 −57.357 1.00 19.97 O ATOM 457 N GLN C 392 35.506 −12.405 −57.903 1.00 19.87 N ATOM 458 CA GLN C 392 35.940 −11.920 −59.197 1.00 20.86 C ATOM 459 CB GLN C 392 37.464 −11.885 −59.260 1.00 23.28 C ATOM 460 CG GLN C 392 38.133 −13.225 −59.075 1.00 25.86 C ATOM 461 CD GLN C 392 39.660 −13.128 −59.140 1.00 32.26 C ATOM 462 OE1 GLN C 392 40.282 −12.260 −58.490 1.00 26.90 O ATOM 463 NE2 GLN C 392 40.272 −14.030 −59.894 1.00 27.93 N ATOM 464 C GLN C 392 35.352 −12.737 −60.348 1.00 17.85 C ATOM 465 O GLN C 392 34.990 −13.910 −60.181 1.00 16.88 O ATOM 466 N CYS C 393 35.240 −12.118 −61.513 1.00 19.45 N ATOM 467 CA CYS C 393 34.659 −12.797 −62.658 1.00 19.09 C ATOM 468 CB CYS C 393 34.573 −11.821 −63.866 1.00 18.54 C ATOM 469 SG CYS C 393 34.104 −12.614 −65.405 1.00 19.35 S ATOM 470 C CYS C 393 35.477 −14.044 −62.998 1.00 20.04 C ATOM 471 O CYS C 393 36.710 −14.014 −63.015 1.00 18.58 O ATOM 472 N LYS C 394 34.787 −15.157 −63.253 1.00 17.98 N ATOM 473 CA LYS C 394 35.438 −16.424 −63.541 1.00 23.56 C ATOM 474 CB LYS C 394 34.364 −17.532 −63.548 1.00 27.76 C ATOM 475 CG LYS C 394 34.845 −18.958 −63.613 1.00 41.83 C ATOM 476 CD LYS C 394 33.660 −19.891 −63.908 1.00 47.55 C ATOM 477 CE LYS C 394 32.862 −19.442 −65.137 1.00 41.86 C ATOM 478 NZ LYS C 394 31.606 −20.233 −65.363 1.00 43.14 N ATOM 479 C LYS C 394 36.180 −16.400 −64.892 1.00 22.67 C ATOM 480 O LYS C 394 37.080 −17.202 −65.116 1.00 21.73 O ATOM 481 N ILE C 395 35.790 −15.478 −65.769 1.00 17.90 N ATOM 482 CA ILE C 395 36.266 −15.458 −67.157 1.00 20.16 C ATOM 483 CB ILE C 395 35.092 −15.143 −68.126 1.00 22.32 C ATOM 484 CG1 ILE C 395 34.020 −16.257 −68.058 1.00 24.88 C ATOM 485 CD1 ILE C 395 34.525 −17.646 −68.359 1.00 33.56 C ATOM 486 CG2 ILE C 395 35.570 −14.943 −69.572 1.00 27.19 C ATOM 487 C ILE C 395 37.442 −14.482 −67.372 1.00 21.30 C ATOM 488 O ILE C 395 38.374 −14.792 −68.120 1.00 24.85 O ATOM 489 N CYS C 396 37.406 −13.319 −66.710 1.00 20.00 N ATOM 490 CA CYS C 396 38.417 −12.260 −66.938 1.00 20.82 C ATOM 491 CB CYS C 396 37.798 −11.084 −67.726 1.00 19.94 C ATOM 492 SG CYS C 396 36.779 −9.967 −66.712 1.00 20.32 S ATOM 493 C CYS C 396 39.088 −11.762 −65.643 1.00 22.88 C ATOM 494 O CYS C 396 39.968 −10.914 −65.684 1.00 19.43 O ATOM 495 N ALA C 397 38.662 −12.306 −64.510 1.00 19.88 N ATOM 496 CA ALA C 397 39.176 −11.925 −63.172 1.00 21.30 C ATOM 497 CB ALA C 397 40.659 −12.315 −62.996 1.00 22.89 C ATOM 498 C ALA C 397 38.927 −10.466 −62.728 1.00 19.34 C ATOM 499 O ALA C 397 39.516 −10.023 −61.741 1.00 21.70 O ATOM 500 N SER C 398 38.025 −9.757 −63.400 1.00 18.04 N ATOM 501 CA SER C 398 37.579 −8.438 −62.920 1.00 23.45 C ATOM 502 CB SER C 398 36.543 −7.840 −63.857 1.00 21.51 C ATOM 503 OG SER C 398 36.076 −6.608 −63.341 1.00 23.91 O ATOM 504 C SER C 398 36.999 −8.544 −61.487 1.00 24.26 C ATOM 505 O SER C 398 36.226 −9.429 −61.204 1.00 19.04 O ATOM 506 N HIS C 399 37.407 −7.647 −60.599 1.00 21.06 N ATOM 507 CA HIS C 399 36.880 −7.621 −59.230 1.00 25.19 C ATOM 508 CB HIS C 399 37.830 −6.845 −58.303 1.00 29.97 C ATOM 509 CG HIS C 399 39.092 −7.597 −57.962 1.00 41.61 C ATOM 510 ND1 HIS C 399 39.824 −8.266 −58.897 1.00 52.11 N ATOM 511 CE1 HIS C 399 40.886 −8.848 −58.300 1.00 50.81 C ATOM 512 NE2 HIS C 399 40.839 −8.557 −56.984 1.00 55.23 N ATOM 513 CD2 HIS C 399 39.750 −7.784 −56.742 1.00 45.49 C ATOM 514 C HIS C 399 35.516 −7.011 −59.235 1.00 22.54 C ATOM 515 O HIS C 399 35.367 −5.810 −59.369 1.00 27.75 O ATOM 516 N ILE C 400 34.484 −7.842 −59.166 1.00 19.81 N ATOM 517 CA ILE C 400 33.158 −7.334 −59.359 1.00 18.67 C ATOM 518 CB ILE C 400 32.291 −8.317 −60.151 1.00 24.31 C ATOM 519 CG1 ILE C 400 32.836 −8.386 −61.594 1.00 26.52 C ATOM 520 CD1 ILE C 400 32.688 −9.737 −62.197 1.00 36.38 C ATOM 521 CG2 ILE C 400 30.843 −7.847 −60.194 1.00 23.19 C ATOM 522 C ILE C 400 32.518 −6.936 −58.025 1.00 19.05 C ATOM 523 O ILE C 400 31.734 −6.001 −57.982 1.00 20.48 O ATOM 524 N GLY C 401 32.897 −7.619 −56.955 1.00 19.04 N ATOM 525 CA GLY C 401 32.429 −7.264 −55.592 1.00 17.46 C ATOM 526 C GLY C 401 32.840 −8.296 −54.568 1.00 20.64 C ATOM 527 O GLY C 401 33.973 −8.783 −54.588 1.00 18.56 O ATOM 528 N TRP C 402 31.890 −8.661 −53.680 1.00 16.67 N ATOM 529 CA TRP C 402 32.162 −9.552 −52.547 1.00 18.77 C ATOM 530 CB TRP C 402 32.456 −8.725 −51.273 1.00 17.10 C ATOM 531 CG TRP C 402 33.579 −7.724 −51.486 1.00 18.87 C ATOM 532 CD1 TRP C 402 34.927 −7.887 −51.170 1.00 19.24 C ATOM 533 NE1 TRP C 402 35.653 −6.796 −51.582 1.00 21.70 N ATOM 534 CE2 TRP C 402 34.836 −5.873 −52.154 1.00 20.62 C ATOM 535 CD2 TRP C 402 33.487 −6.414 −52.123 1.00 17.20 C ATOM 536 CE3 TRP C 402 32.439 −5.661 −52.680 1.00 19.43 C ATOM 537 CZ3 TRP C 402 32.744 −4.408 −53.245 1.00 21.99 C ATOM 538 CH2 TRP C 402 34.052 −3.897 −53.225 1.00 21.39 C ATOM 539 CZ2 TRP C 402 35.122 −4.628 −52.702 1.00 20.52 C ATOM 540 C TRP C 402 31.000 −10.459 −52.270 1.00 17.94 C ATOM 541 O TRP C 402 29.849 −10.077 −52.475 1.00 18.07 O ATOM 542 N LYS C 403 31.286 −11.641 −51.739 1.00 18.13 N ATOM 543 CA LYS C 403 30.236 −12.459 −51.130 1.00 16.95 C ATOM 544 CB LYS C 403 30.569 −13.920 −51.273 1.00 18.86 C ATOM 545 CG LYS C 403 29.489 −14.897 −50.782 1.00 22.97 C ATOM 546 CD LYS C 403 29.997 −16.361 −50.914 1.00 23.46 C ATOM 547 CE LYS C 403 28.848 −17.393 −50.801 1.00 28.58 C ATOM 548 NZ LYS C 403 29.373 −18.801 −50.910 1.00 29.32 N ATOM 549 C LYS C 403 30.205 −12.083 −49.655 1.00 18.92 C ATOM 550 O LYS C 403 31.241 −12.073 −49.003 1.00 20.66 O ATOM 551 N PHE C 404 29.025 −11.762 −49.150 1.00 16.91 N ATOM 552 CA PHE C 404 28.840 −11.459 −47.751 1.00 16.49 C ATOM 553 CB PHE C 404 27.987 −10.196 −47.598 1.00 16.81 C ATOM 554 CG PHE C 404 28.759 −8.930 −47.859 1.00 19.51 C ATOM 555 CD1 PHE C 404 29.562 −8.366 −46.848 1.00 20.30 C ATOM 556 CE1 PHE C 404 30.311 −7.195 −47.094 1.00 18.87 C ATOM 557 CZ PHE C 404 30.286 −6.616 −43.353 1.00 18.27 C ATOM 558 CE2 PHE C 404 29.505 −7.192 −49.378 1.00 18.70 C ATOM 559 CD2 PHE C 404 28.752 −8.336 −49.130 1.00 18.09 C ATOM 560 C PHE C 404 28.179 −12.619 −47.053 1.00 21.35 C ATOM 561 O PHE C 404 27.173 −13.108 −47.525 1.00 19.54 O ATOM 562 N THR C 405 28.790 −13.100 −45.966 1.00 17.15 N ATOM 563 CA THR C 405 28.253 −14.252 −45.217 1.00 19.24 C ATOM 564 CB THR C 405 29.225 −15.467 −45.263 1.00 23.03 C ATOM 565 OG1 THR C 405 30.565 −15.033 −44.985 1.00 24.85 O ATOM 566 CG2 THR C 405 29.185 −16.138 −46.643 1.00 24.42 C ATOM 567 C THR C 405 27.989 −13.886 −43.753 1.00 26.02 C ATOM 568 O THR C 405 28.837 −13.247 −43.115 1.00 20.95 O ATOM 569 N ALA C 406 26.822 −14.301 −43.228 1.00 22.39 N ATOM 570 CA ALA C 406 26.368 −13.939 −41.867 1.00 21.73 C ATOM 571 CB ALA C 406 24.938 −14.456 −41.645 1.00 19.03 C ATOM 572 C ALA C 406 27.296 −14.572 −40.840 1.00 24.62 C ATOM 573 O ALA C 406 27.635 −15.733 −40.968 1.00 22.12 O ATOM 574 N THR C 407 27.689 −13.808 −39.813 1.00 23.76 N ATOM 575 CA THR C 407 28.450 −14.369 −38.700 1.00 26.36 C ATOM 576 CB THR C 407 29.275 −13.287 −37.981 1.00 25.54 C ATOM 577 OG1 THR C 407 28.393 −12.261 −37.548 1.00 24.00 O ATOM 578 CG2 THR C 407 30.320 −12.688 −38.921 1.00 26.73 C ATOM 579 C THR C 407 27.565 −15.069 −37.646 1.00 28.21 C ATOM 580 O THR C 407 28.080 −15.804 −36.813 1.00 31.23 O ATOM 581 N LYS C 408 26.249 −14.819 −37.677 1.00 29.81 N ATOM 582 CA LYS C 408 25.294 −15.479 −36.740 1.00 30.93 C ATOM 583 CB LYS C 408 24.672 −14.460 −35.776 1.00 30.17 C ATOM 584 CG LYS C 408 25.642 −13.846 −34.750 1.00 40.43 C ATOM 585 CD LYS C 408 26.527 −14.894 −34.057 1.00 49.28 C ATOM 586 CE LYS C 408 25.775 −15.671 −32.974 1.00 61.81 C ATOM 587 NZ LYS C 408 26.354 −15.481 −31.613 1.00 73.95 N ATOM 588 C LYS C 408 24.180 −16.212 −37.479 1.00 31.23 C ATOM 589 O LYS C 408 23.667 −15.723 −38.489 1.00 24.35 O ATOM 590 N LYS C 409 23.775 −17.357 −36.944 1.00 29.82 N ATOM 591 CA LYS C 409 22.792 −18.221 −37.602 1.00 30.44 C ATOM 592 CB LYS C 409 22.754 −19.590 −36.923 1.00 41.17 C ATOM 593 CG LYS C 409 24.120 −20.235 −36.715 1.00 52.84 C ATOM 594 CD LYS C 409 24.343 −21.420 −37.634 1.00 51.99 C ATOM 595 CE LYS C 409 24.663 −20.968 −39.044 1.00 49.47 C ATOM 596 NZ LYS C 409 24.404 −22.062 −40.012 1.00 64.48 N ATOM 597 C LYS C 409 21.396 −17.640 −37.643 1.00 26.60 C ATOM 598 O LYS C 409 20.559 −18.083 −38.440 1.00 29.24 O ATOM 599 N ASP C 410 21.111 −16.663 −36.786 1.00 24.16 N ATOM 600 CA ASP C 410 19.737 −16.101 −36.726 1.00 28.97 C ATOM 601 CB ASP C 410 19.386 −15.652 −35.291 1.00 36.10 C ATOM 602 CG ASP C 410 20.260 −14.478 −34.803 1.00 50.41 C ATOM 603 OD1 ASP C 410 21.246 −14.118 −35.494 1.00 52.57 O ATOM 604 OD2 ASP C 410 19.953 −13.914 −33.731 1.00 59.08 O ATOM 605 C ASP C 410 19.447 −14.974 −37.755 1.00 29.67 C ATOM 606 O ASP C 410 18.320 −14.463 −37.825 1.00 30.30 O ATOM 607 N MET C 411 20.459 −14.590 −38.546 1.00 22.42 N ATOM 608 CA MET C 411 20.297 −13.530 −39.565 1.00 24.51 C ATOM 609 CB MET C 411 21.646 −12.864 −39.835 1.00 25.24 C ATOM 610 CG MET C 411 22.235 −12.210 −38.578 1.00 28.71 C ATOM 611 SD MET C 411 23.976 −11.852 −38.825 1.00 27.69 S ATOM 612 CE MET C 411 23.819 −10.572 −40.083 1.00 28.09 C ATOM 613 C MET C 411 19.691 −14.032 −40.910 1.00 19.94 C ATOM 614 O MET C 411 19.848 −15.198 −41.275 1.00 22.66 O ATOM 615 N SER C 412 19.002 −13.146 −41.616 1.00 19.30 N ATOM 616 CA SER C 412 18.581 −13.434 −42.985 1.00 21.53 C ATOM 617 CB SER C 412 17.070 −13.755 −43.090 1.00 23.43 C ATOM 618 OG SER C 412 16.266 −12.675 −42.707 1.00 25.81 O ATOM 619 C SER C 412 19.037 −12.343 −43.933 1.00 22.36 C ATOM 620 O SER C 412 18.874 −11.164 −43.600 1.00 19.15 O ATOM 621 N PRO C 413 19.174 −12.700 −45.220 1.00 19.34 N ATOM 622 CA PRO C 413 19.897 −13.867 −45.702 1.00 18.19 C ATOM 623 CB PRO C 413 20.169 −13.524 −47.170 1.00 20.62 C ATOM 624 CG PRO C 413 20.428 −12.049 −47.133 1.00 20.02 C ATOM 625 CD PRO C 413 19.526 −11.496 −46.018 1.00 19.00 C ATOM 626 C PRO C 413 21.161 −14.229 −44.980 1.00 19.66 C ATOM 627 O PRO C 413 21.871 −13.343 −44.477 1.00 18.72 O ATOM 628 N GLN C 414 21.460 −15.530 −44.952 1.00 17.84 N ATOM 629 CA GLN C 414 22.714 −16.019 −44.415 1.00 18.92 C ATOM 630 CB GLN C 414 22.674 −17.559 −44.251 1.00 22.91 C ATOM 631 CG GLN C 414 21.942 −18.013 −42.971 1.00 22.25 C ATOM 632 CD GLN C 414 22.702 −17.596 −41.718 1.00 21.57 C ATOM 633 OE1 GLN C 414 22.292 −16.687 −40.978 1.00 24.32 O ATOM 634 NE2 GLN C 414 23.807 −18.207 −41.514 1.00 17.55 N ATOM 635 C GLN C 414 23.880 −15.617 −45.325 1.00 20.42 C ATOM 636 O GLN C 414 25.029 −15.627 −44.907 1.00 19.54 O ATOM 637 N LYS C 415 23.580 −15.330 −46.587 1.00 17.15 N ATOM 638 CA LYS C 415 24.607 −14.837 −47.502 1.00 20.13 C ATOM 639 CB LYS C 415 25.524 −15.968 −48.033 1.00 28.49 C ATOM 640 CG LYS C 415 24.997 −16.768 −49.202 1.00 29.92 C ATOM 641 CD LYS C 415 25.210 −16.048 −50.534 1.00 23.94 C ATOM 642 CE LYS C 415 24.598 −16.837 −51.667 1.00 32.53 C ATOM 643 NZ LYS C 415 23.775 −17.966 −51.145 1.00 24.42 N ATOM 644 C LYS C 415 23.982 −14.040 −48.614 1.00 17.08 C ATOM 645 O LYS C 415 22.807 −14.210 −48.934 1.00 15.14 O ATOM 646 N PHE C 416 24.757 −13.120 −49.173 1.00 15.09 N ATOM 647 CA PHE C 416 24.302 −12.371 −50.332 1.00 14.01 C ATOM 648 CB PHE C 416 23.323 −11.233 −49.936 1.00 14.25 C ATOM 649 CG PHE C 416 23.941 −10.160 −49.092 1.00 17.62 C ATOM 650 CD2 PHE C 416 24.520 −9.016 −49.690 1.00 16.75 C ATOM 651 CE2 PHE C 416 25.121 −8.038 −48.898 1.00 15.95 C ATOM 652 CZ PHE C 416 25.155 −8.166 −47.506 1.00 17.92 C ATOM 653 CE1 PHE C 416 24.598 −9.276 −46.901 1.00 19.40 C ATOM 654 CD1 PHE C 416 24.004 −10.289 −47.696 1.00 18.32 C ATOM 655 C PHE C 416 25.565 −11.854 −51.039 1.00 14.42 C ATOM 656 O PHE C 416 26.688 −12.146 −50.604 1.00 16.22 O ATOM 657 N TRP C 417 25.378 −11.209 −52.161 1.00 15.71 N ATOM 658 CA TRP C 417 26.493 −10.641 −52.897 1.00 15.70 C ATOM 659 CB TRP C 417 26.488 −11.186 −54.339 1.00 17.05 C ATOM 660 CG TRP C 417 26.539 −12.704 −54.391 1.00 15.37 C ATOM 661 CD1 TRP C 417 25.463 −13.599 −54.295 1.00 16.48 C ATOM 662 NE1 TRP C 417 25.910 −14.902 −54.342 1.00 17.26 N ATOM 663 CE2 TRP C 417 27.263 −14.930 −54.492 1.00 17.73 C ATOM 664 CD2 TRP C 417 27.729 −13.544 −54.511 1.00 14.96 C ATOM 665 CE3 TRP C 417 29.090 −13.292 −54.645 1.00 15.98 C ATOM 666 CZ3 TRP C 417 29.956 −14.360 −54.752 1.00 17.30 C ATOM 667 CH2 TRP C 417 29.482 −15.700 −54.739 1.00 18.29 C ATOM 668 CZ2 TRP C 417 28.129 −15.994 −54.590 1.00 17.76 C ATOM 669 C TRP C 417 26.376 −9.153 −52.902 1.00 16.99 C ATOM 670 O TRP C 417 25.328 −8.621 −53.214 1.00 17.97 O ATOM 671 N GLY C 418 27.458 −8.461 −52.557 1.00 18.07 N ATOM 672 CA GLY C 418 27.504 −7.005 −52.736 1.00 15.90 C ATOM 673 C GLY C 418 28.404 −6.681 −53.930 1.00 17.29 C ATOM 674 O GLY C 418 29.602 −6.999 −53.927 1.00 18.19 O ATOM 675 N LEU C 419 27.814 −6.126 −54.964 1.00 16.90 N ATOM 676 CA LEU C 419 28.512 −5.984 −56.235 1.00 18.19 C ATOM 677 CB LEU C 419 27.727 −6.670 −57.360 1.00 18.51 C ATOM 678 CG LEU C 419 27.373 −8.152 −57.100 1.00 15.00 C ATOM 679 CD1 LEU C 419 26.518 −8.685 −58.276 1.00 22.36 C ATOM 680 CD2 LEU C 419 28.638 −8.998 −56.948 1.00 18.73 C ATOM 681 C LEU C 419 28.693 −4.513 −56.547 1.00 19.38 C ATOM 682 O LEU C 419 27.799 −3.700 −56.322 1.00 20.12 O ATOM 683 N THR C 420 29.860 −4.184 −57.079 1.00 20.93 N ATOM 684 CA THR C 420 30.126 −2.798 −57.508 1.00 21.16 C ATOM 685 CB THR C 420 31.626 −2.601 −57.689 1.00 20.72 C ATOM 686 OG1 THR C 420 32.267 −2.919 −56.460 1.00 21.86 O ATOM 687 CG2 THR C 420 31.941 −1.142 −58.061 1.00 25.37 C ATOM 688 C THR C 420 29.384 −2.496 −58.792 1.00 18.26 C ATOM 689 O THR C 420 29.657 −3.118 −59.827 1.00 20.69 O ATOM 690 N ARG C 421 28.425 −1.562 −58.734 1.00 18.70 N ATOM 691 CA ARG C 421 27.495 −1.329 −59.842 1.00 24.01 C ATOM 692 CB ARG C 421 26.450 −0.272 −59.453 1.00 24.40 C ATOM 693 CG ARG C 421 25.344 −0.063 −60.487 1.00 29.73 C ATOM 694 CD ARG C 421 24.643 −1.373 −60.859 1.00 40.72 C ATOM 695 NE ARG C 421 23.762 −1.234 −62.020 1.00 43.02 N ATOM 696 CZ ARG C 421 24.160 −1.331 −63.288 1.00 44.26 C ATOM 697 NH1 ARG C 421 23.282 −1.182 −64.267 1.00 51.63 N ATOM 698 NH2 ARG C 421 25.435 −1.571 −63.578 1.00 37.17 N ATOM 699 C ARG C 421 28.224 −0.927 −61.142 1.00 23.35 C ATOM 700 O ARG C 421 27.842 −1.322 −62.246 1.00 21.27 O ATOM 701 N SER C 422 29.294 −0.169 −60.998 1.00 25.80 N ATOM 702 CA SER C 422 30.024 0.303 −62.169 1.00 25.90 C ATOM 703 CB SER C 422 30.898 1.501 −61.785 1.00 26.05 C ATOM 704 OG SER C 422 31.809 1.122 −60.780 1.00 27.22 O ATOM 705 C SER C 422 30.877 −0.814 −62.793 1.00 24.71 C ATOM 706 O SER C 422 31.435 −0.629 −63.873 1.00 24.39 O ATOM 707 N ALA C 423 31.003 −1.955 −62.103 1.00 19.01 N ATOM 708 CA ALA C 423 31.690 −3.120 −62.679 1.00 22.75 C ATOM 709 CB ALA C 423 32.421 −3.930 −61.583 1.00 22.48 C ATOM 710 C ALA C 423 30.735 −4.009 −63.505 1.00 22.65 C ATOM 711 O ALA C 423 31.144 −5.036 −64.076 1.00 22.56 O ATOM 712 N LEU C 424 29.470 −3.609 −63.584 1.00 19.91 N ATOM 713 CA LEU C 424 28.470 −4.380 −64.309 1.00 20.15 C ATOM 714 CB LEU C 424 27.345 −4.849 −63.365 1.00 20.70 C ATOM 715 CG LEU C 424 27.798 −5.765 −62.210 1.00 21.77 C ATOM 716 CD1 LEU C 424 26.661 −5.860 −61.188 1.00 22.15 C ATOM 717 CD2 LEU C 424 28.145 −7.152 −62.719 1.00 20.26 C ATOM 718 C LEU C 424 27.866 −3.624 −65.455 1.00 24.37 C ATOM 719 O LEU C 424 27.809 −2.387 −65.443 1.00 23.14 O ATOM 720 N LEU C 425 27.317 −4.386 −66.389 1.00 24.58 N ATOM 721 CA LEU C 425 26.871 −3.873 −67.650 1.00 28.23 C ATOM 722 CB LEU C 425 27.747 −4.461 −68.760 1.00 33.87 C ATOM 723 CG LEU C 425 27.622 −3.891 −70.155 1.00 43.65 C ATOM 724 CD1 LEU C 425 28.279 −2.516 −70.204 1.00 36.35 C ATOM 725 CD2 LEU C 425 28.254 −4.868 −71.148 1.00 30.51 C ATOM 726 C LEU C 425 25.385 −4.138 −67.976 1.00 46.90 C ATOM 727 O LEU C 425 25.026 −5.251 −68.379 1.00 57.13 O ATOM 728 N PRO C 426 24.515 −3.188 −67.612 1.00 36.98 N ATOM 729 CA PRO C 426 24.072 −2.174 −68.552 1.00 49.43 C ATOM 730 CB PRO C 426 22.532 −2.216 −68.434 1.00 43.05 C ATOM 731 CG PRO C 426 22.234 −3.445 −67.638 1.00 47.02 C ATOM 732 CD PRO C 426 23.413 −3.577 −66.731 1.00 61.94 C ATOM 733 C PRO C 426 24.632 −0.823 −68.063 1.00 67.43 C ATOM 734 O PRO C 426 25.051 −0.715 −66.893 1.00 58.16 O ATOM 735 N THR C 427 24.659 0.174 −68.952 1.00 78.64 N ATOM 736 CA THR C 427 25.321 1.477 −68.704 1.00 73.20 C ATOM 737 CB THR C 427 24.547 2.648 −69.376 1.00 83.46 C ATOM 738 OG1 THR C 427 24.019 2.219 −70.641 1.00 82.68 O ATOM 739 CG2 THR C 427 25.465 3.859 −69.596 1.00 75.73 C ATOM 740 C THR C 427 25.573 1.783 −67.219 1.00 69.85 C ATOM 741 O THR C 427 24.930 2.651 −66.625 1.00 72.74 O ATOM 742 N THR A 321 4.551 −15.893 −65.318 1.00 40.43 N ATOM 743 CA THR A 321 5.957 −16.283 −64.916 1.00 35.08 C ATOM 744 CB THR A 321 6.662 −15.217 −64.026 1.00 40.21 C ATOM 745 OG1 THR A 321 6.151 −15.287 −62.681 1.00 36.05 O ATOM 746 CG2 THR A 321 6.511 −13.784 −64.607 1.00 45.57 C ATOM 747 C THR A 321 6.086 −17.660 −64.202 1.00 26.92 C ATOM 748 O THR A 321 7.182 −18.122 −64.015 1.00 21.10 O ATOM 749 N SER A 322 4.966 −18.271 −63.787 1.00 22.22 N ATOM 750 CA ASER A 322 4.980 −19.619 −63.228 0.50 20.83 C ATOM 751 CA BSER A 322 4.979 −19.642 −63.240 0.50 20.81 C ATOM 752 CB ASER A 322 3.603 −19.944 −62.624 0.50 23.57 C ATOM 753 CB BSER A 322 3.606 −20.013 −62.662 0.50 23.10 C ATOM 754 OG ASER A 322 3.576 −21.241 −62.093 0.50 20.43 O ATOM 755 OG BSER A 322 3.461 −19.505 −61.365 0.50 20.90 O ATOM 756 C SER A 322 5.337 −20.661 −64.298 1.00 22.53 C ATOM 757 O SER A 322 4.727 −20.695 −65.374 1.00 24.80 O ATOM 758 N LEU A 323 6.296 −21.522 −63.999 1.00 16.02 N ATOM 759 CA LEU A 323 6.610 −22.635 −64.897 1.00 18.17 C ATOM 760 CB LEU A 323 8.082 −22.610 −65.355 1.00 19.53 C ATOM 761 CG LEU A 323 8.522 −21.321 −66.100 1.00 21.51 C ATOM 762 CD1 LEU A 323 10.038 −21.185 −66.165 1.00 22.36 C ATOM 763 CD2 LEU A 323 7.972 −21.344 −67.487 1.00 24.81 C ATOM 764 C LEU A 323 6.239 −23.963 −64.241 1.00 18.39 C ATOM 765 O LEU A 323 6.885 −24.396 −63.264 1.00 16.27 O ATOM 766 N CYS A 324 5.183 −24.593 −64.761 1.00 16.53 N ATOM 767 CA CYS A 324 4.579 −25.796 −64.126 1.00 17.38 C ATOM 768 CB CYS A 324 3.057 −25.648 −64.099 1.00 21.85 C ATOM 769 SG CYS A 324 2.560 −24.369 −62.948 1.00 24.08 S ATOM 770 C CYS A 324 4.934 −27.063 −64.877 1.00 18.86 C ATOM 771 O CYS A 324 5.230 −27.015 −66.074 1.00 17.93 O ATOM 772 N CYS A 325 4.936 −28.190 −64.164 1.00 14.36 N ATOM 773 CA CYS A 325 5.081 −29.506 −64.786 1.00 17.37 C ATOM 774 CB CYS A 325 4.883 −30.614 −63.735 1.00 15.30 C ATOM 775 SG CYS A 325 4.948 −32.271 −64.439 1.00 17.23 S ATOM 776 C CYS A 325 4.002 −29.629 −65.879 1.00 18.91 C ATOM 777 O CYS A 325 2.796 −29.473 −65.605 1.00 15.89 O ATOM 778 N LYS A 326 4.424 −29.942 −67.092 1.00 17.65 N ATOM 779 CA LYS A 326 3.494 −30.047 −68.241 1.00 19.82 C ATOM 780 CB LYS A 326 4.308 −30.252 −69.552 1.00 21.78 C ATOM 781 CG LYS A 326 3.455 −30.439 −70.820 1.00 27.83 C ATOM 782 CD LYS A 326 4.306 −30.420 −72.113 1.00 21.59 C ATOM 783 CE LYS A 326 5.133 −31.707 −72.261 1.00 33.76 C ATOM 784 NZ LYS A 326 5.957 −31.770 −73.533 1.00 26.41 N ATOM 785 C LYS A 326 2.482 −31.224 −68.056 1.00 21.44 C ATOM 786 O LYS A 326 1.307 −31.137 −68.469 1.00 20.61 O ATOM 787 N GLN A 327 2.957 −32.290 −67.431 1.00 17.27 N ATOM 788 CA GLN A 327 2.209 −33.507 −67.259 1.00 20.63 C ATOM 789 CB GLN A 327 3.140 −34.661 −66.835 1.00 19.02 C ATOM 790 CG GLN A 327 2.402 −35.976 −66.562 1.00 19.78 C ATOM 791 CD GLN A 327 1.568 −36.397 −67.748 1.00 24.09 C ATOM 792 OE1 GLN A 327 2.065 −36.435 −68.865 1.00 23.94 O ATOM 793 NE2 GLN A 327 0.290 −36.713 −67.514 1.00 22.24 N ATOM 794 C GLN A 327 1.073 −33.350 −66.263 1.00 22.86 C ATOM 795 O GLN A 327 −0.083 −33.491 −66.629 1.00 19.94 O ATOM 796 N CYS A 328 1.391 −33.075 −64.994 1.00 18.52 N ATOM 797 CA CYS A 328 0.302 −32.929 −63.962 1.00 20.13 C ATOM 798 CB CYS A 328 0.795 −33.348 −62.562 1.00 17.71 C ATOM 799 SG CYS A 328 2.103 −32.303 −61.880 1.00 18.05 S ATOM 800 C CYS A 328 −0.317 −31.535 −63.932 1.00 21.52 C ATOM 801 O CYS A 328 −1.331 −31.313 −63.267 1.00 18.91 O ATOM 802 N GLN A 329 0.311 −30.594 −64.652 1.00 17.87 N ATOM 803 CA GLN A 329 −0.242 −29.243 −64.918 1.00 21.29 C ATOM 804 CB GLN A 329 −1.667 −29.332 −65.562 1.00 21.81 C ATOM 805 CG GLN A 329 −1.680 −30.200 −66.809 1.00 20.31 C ATOM 806 CD GLN A 329 −3.074 −30.352 −67.423 1.00 24.94 C ATOM 807 OE1 GLN A 329 −3.462 −31.435 −67.849 1.00 31.31 O ATOM 808 NE2 GLN A 329 −3.826 −29.283 −67.429 1.00 27.47 N ATOM 809 C GLN A 329 −0.242 −28.276 −63.727 1.00 23.05 C ATOM 810 O GLN A 329 0.013 −27.081 −63.897 1.00 27.20 O ATOM 811 N GLU A 330 −0.492 −28.792 −62.526 1.00 22.09 N ATOM 812 CA GLU A 330 −0.784 −27.957 −61.354 1.00 23.02 C ATOM 813 CB GLU A 330 −1.774 −28.703 −60.422 1.00 25.71 C ATOM 814 CG GLU A 330 −1.185 −29.996 −59.814 1.00 29.94 C ATOM 815 CD GLU A 330 −2.152 −30.756 −58.900 1.00 43.29 C ATOM 816 OE1 GLU A 330 −1.780 −31.868 −58.409 1.00 38.45 O ATOM 817 OE2 GLU A 330 −3.280 −30.263 −58.682 1.00 47.09 O ATOM 818 C GLU A 330 0.481 −27.630 −60.530 1.00 24.14 C ATOM 819 O GLU A 330 0.473 −26.737 −59.691 1.00 26.86 O ATOM 820 N THR A 331 1.531 −28.406 −60.723 1.00 20.99 N ATOM 821 CA THR A 331 2.680 −28.355 −59.816 1.00 16.99 C ATOM 822 CB THR A 331 3.328 −29.763 −59.685 1.00 20.62 C ATOM 823 OG1 THR A 331 2.320 −30.714 −59.261 1.00 22.37 O ATOM 824 CG2 THR A 331 4.459 −29.760 −58.679 1.00 18.91 C ATOM 825 C THR A 331 3.702 −27.368 −60.383 1.00 19.75 C ATOM 826 O THR A 331 4.257 −27.593 −61.461 1.00 16.32 O ATOM 827 N GLU A 332 3.964 −26.294 −59.655 1.00 16.74 N ATOM 828 CA GLU A 332 4.926 −25.315 −60.131 1.00 15.89 C ATOM 829 CB GLU A 332 4.728 −23.977 −59.441 1.00 20.69 C ATOM 830 CG GLU A 332 5.675 −22.891 −59.976 1.00 20.54 C ATOM 831 CD GLU A 332 5.504 −21.578 −59.238 1.00 21.74 C ATOM 832 OE1 GLU A 332 4.552 −20.819 −59.570 1.00 22.95 O ATOM 833 OE2 GLU A 332 6.296 −21.334 −58.305 1.00 21.04 O ATOM 834 C GLU A 332 6.324 −25.832 −59.842 1.00 17.94 C ATOM 835 O GLU A 332 6.620 −26.316 −58.714 1.00 13.91 O ATOM 836 N ILE A 333 7.192 −25.729 −60.828 1.00 13.85 N ATOM 837 CA ILE A 333 8.535 −26.218 −60.644 1.00 14.17 C ATOM 838 CB ILE A 333 8.973 −27.127 −61.824 1.00 13.98 C ATOM 839 CG1 ILE A 333 8.042 −28.366 −61.958 1.00 16.52 C ATOM 840 CD1 ILE A 333 8.007 −29.258 −60.701 1.00 16.65 C ATOM 841 CG2 ILE A 333 10.398 −27.580 −61.618 1.00 14.79 C ATOM 842 C ILE A 333 9.512 −25.052 −60.493 1.00 16.43 C ATOM 843 O ILE A 333 10.466 −25.137 −59.754 1.00 16.72 O ATOM 844 N THR A 334 9.299 −23.985 −61.236 1.00 18.04 N ATOM 845 CA THR A 334 10.163 −22.794 −61.057 1.00 18.02 C ATOM 846 CB THR A 334 11.560 −22.975 −61.759 1.00 19.08 C ATOM 847 OG1 THR A 334 12.452 −21.942 −61.322 1.00 17.19 O ATOM 848 CG2 THR A 334 11.424 −22.890 −63.282 1.00 17.72 C ATOM 849 C THR A 334 9.411 −21.574 −61.560 1.00 17.69 C ATOM 850 O THR A 334 8.191 −21.661 −61.874 1.00 15.70 O ATOM 851 N THR A 335 10.077 −20.418 −61.552 1.00 18.19 N ATOM 852 CA THR A 335 9.504 −19.215 −62.107 1.00 17.81 C ATOM 853 CB THR A 335 9.118 −18.184 −61.001 1.00 19.86 C ATOM 854 OG1 THR A 335 10.299 −17.548 −60.507 1.00 20.96 O ATOM 855 CG2 THR A 335 8.364 −18.859 −59.842 1.00 18.72 C ATOM 856 C THR A 335 10.507 −18.558 −63.056 1.00 18.93 C ATOM 857 O THR A 335 11.718 −18.769 −62.955 1.00 17.73 O ATOM 858 N LYS A 336 10.000 −17.749 −63.969 1.00 17.52 N ATOM 859 CA LYS A 336 10.877 −17.054 −64.887 1.00 20.23 C ATOM 860 CB LYS A 336 10.056 −16.251 −65.886 1.00 24.57 C ATOM 861 CG LYS A 336 9.315 −17.096 −66.900 1.00 34.21 C ATOM 862 CD LYS A 336 8.522 −16.200 −67.851 1.00 39.66 C ATOM 863 CE LYS A 336 8.113 −16.955 −69.112 1.00 39.73 C ATOM 864 NZ LYS A 336 7.286 −16.092 −69.994 1.00 50.40 N ATOM 865 C LYS A 336 11.860 −16.132 −64.152 1.00 19.64 C ATOM 866 O LYS A 336 12.921 −15.776 −64.690 1.00 18.58 O ATOM 867 N ASN A 337 11.507 −15.734 −62.929 1.00 18.00 N ATOM 868 CA ASN A 337 12.379 −14.870 −62.136 1.00 16.43 C ATOM 869 CB ASN A 337 11.670 −14.398 −60.849 1.00 20.21 C ATOM 870 CG ASN A 337 10.456 −13.587 −61.137 1.00 27.33 C ATOM 871 OD1 ASN A 337 9.341 −13.995 −60.840 1.00 34.10 O ATOM 872 ND2 ASN A 337 10.651 −12.458 −61.750 1.00 30.05 N ATOM 873 C ASN A 337 13.654 −15.541 −61.751 1.00 16.44 C ATOM 874 O ASN A 337 14.613 −14.872 −61.402 1.00 18.69 O ATOM 875 N GLU A 338 13.670 −16.882 −61.774 1.00 14.36 N ATOM 876 CA GLU A 338 14.827 −17.616 −61.313 1.00 14.66 C ATOM 877 CB GLU A 338 14.412 −18.905 −60.583 1.00 15.42 C ATOM 878 CG GLU A 338 13.512 −18.667 −59.386 1.00 16.28 C ATOM 879 CD GLU A 338 14.143 −17.734 −58.364 1.00 24.39 C ATOM 880 OE1 GLU A 338 15.359 −17.876 −58.072 1.00 21.18 O ATOM 881 OE2 GLU A 338 13.435 −16.829 −57.872 1.00 28.39 O ATOM 882 C GLU A 338 15.815 −17.953 −62.434 1.00 15.18 C ATOM 883 O GLU A 338 16.868 −18.560 −62.170 1.00 14.91 O ATOM 884 N ILE A 339 15.497 −17.550 −63.665 1.00 14.51 N ATOM 885 CA ILE A 339 16.351 −17.929 −64.828 1.00 15.89 C ATOM 886 CB ILE A 339 15.611 −17.655 −66.171 1.00 18.62 C ATOM 887 CG1 ILE A 339 14.398 −18.598 −66.317 1.00 17.98 C ATOM 888 CD1 ILE A 339 13.378 −18.137 −67.361 1.00 21.22 C ATOM 889 CG2 ILE A 339 16.573 −17.768 −67.371 1.00 16.54 C ATOM 890 C ILE A 339 17.665 −17.145 −64.771 1.00 17.67 C ATOM 891 O ILE A 339 17.655 −15.956 −64.495 1.00 16.43 O ATOM 892 N PHE A 340 18.788 −17.805 −65.058 1.00 16.24 N ATOM 893 CA PHE A 340 20.076 −17.092 −65.178 1.00 17.14 C ATOM 894 CB PHE A 340 20.831 −17.067 −63.829 1.00 14.44 C ATOM 895 CG PHE A 340 21.468 −18.362 −63.470 1.00 17.90 C ATOM 896 CD2 PHE A 340 22.848 −18.543 −63.613 1.00 17.59 C ATOM 897 CE2 PHE A 340 23.442 −19.772 −63.316 1.00 15.90 C ATOM 898 CZ PHE A 340 22.657 −20.840 −62.840 1.00 17.74 C ATOM 899 CE1 PHE A 340 21.281 −20.664 −62.680 1.00 15.22 C ATOM 900 CD1 PHE A 340 20.691 −19.442 −62.977 1.00 17.65 C ATOM 901 C PHE A 340 20.906 −17.797 −66.238 1.00 21.57 C ATOM 902 O PHE A 340 20.539 −18.867 −66.694 1.00 18.80 O ATOM 903 N SER A 341 22.025 −17.193 −66.609 1.00 20.31 N ATOM 904 CA SER A 341 22.884 −17.736 −67.662 1.00 23.83 C ATOM 905 CB SER A 341 23.020 −16.719 −68.802 1.00 32.15 C ATOM 906 OG SER A 341 23.983 −17.134 −69.770 1.00 40.08 O ATOM 907 C SER A 341 24.245 −18.128 −67.090 1.00 25.00 C ATOM 908 O SER A 341 25.009 −17.273 −66.634 1.00 24.73 O ATOM 909 N LEU A 342 24.520 −19.439 −67.058 1.00 23.54 N ATOM 910 CA LEU A 342 25.846 −19.936 −66.661 1.00 28.00 C ATOM 911 CB LEU A 342 25.760 −21.407 −66.224 1.00 25.89 C ATOM 912 CG LEU A 342 26.376 −21.963 −64.932 1.00 38.88 C ATOM 913 CD1 LEU A 342 26.759 −23.424 −65.109 1.00 33.04 C ATOM 914 CD2 LEU A 342 27.577 −21.187 −64.452 1.00 37.66 C ATOM 915 C LEU A 342 26.790 −19.797 −67.876 1.00 32.97 C ATOM 916 O LEU A 342 26.406 −20.106 −69.018 1.00 33.19 O ATOM 917 N SER A 343 28.000 −19.303 −67.654 1.00 33.59 N ATOM 918 CA SER A 343 28.960 −19.184 −68.768 1.00 36.09 C ATOM 919 CB SER A 343 30.112 −18.237 −68.418 1.00 47.49 C ATOM 920 OG SER A 343 30.925 −17.990 −69.561 1.00 47.59 O ATOM 921 C SER A 343 29.477 −20.582 −69.124 1.00 39.94 C ATOM 922 O SER A 343 29.945 −21.327 −68.241 1.00 39.31 O ATOM 923 N LEU A 344 29.343 −20.943 −70.402 1.00 41.77 N ATOM 924 CA LEU A 344 29.561 −22.321 −70.869 1.00 60.36 C ATOM 925 CB LEU A 344 28.345 −22.829 −71.675 1.00 63.72 C ATOM 926 CG LEU A 344 27.198 −23.540 −70.926 1.00 63.73 C ATOM 927 CD1 LEU A 344 26.115 −22.561 −70.503 1.00 57.76 C ATOM 928 CD2 LEU A 344 26.594 −24.653 −71.777 1.00 59.87 C ATOM 929 C LEU A 344 30.825 −22.426 −71.709 1.00 60.83 C ATOM 930 O LEU A 344 31.926 −22.220 −71.209 1.00 58.36 O ATOM 931 N GLU A 360 15.572 −26.816 −75.530 1.00 54.54 N ATOM 932 CA GLU A 360 16.834 −26.886 −74.818 1.00 40.63 C ATOM 933 CB GLU A 360 17.692 −25.669 −75.147 1.00 38.50 C ATOM 934 CG GLU A 360 16.953 −24.347 −75.030 1.00 44.38 C ATOM 935 CD GLU A 360 17.629 −23.222 −75.799 1.00 59.24 C ATOM 936 OE1 GLU A 360 16.906 −22.327 −76.290 1.00 61.79 O ATOM 937 OE2 GLU A 360 18.878 −23.228 −75.912 1.00 58.29 O ATOM 938 C GLU A 360 16.655 −27.007 −73.283 1.00 38.18 C ATOM 939 O GLU A 360 15.652 −27.604 −72.783 1.00 26.68 O ATOM 940 N THR A 361 17.625 −26.441 −72.556 1.00 27.62 N ATOM 941 CA THR A 361 17.752 −26.621 −71.076 1.00 32.19 C ATOM 942 CB THR A 361 19.050 −27.375 −70.711 1.00 34.38 C ATOM 943 OG1 THR A 361 19.014 −28.701 −71.259 1.00 41.61 O ATOM 944 CG2 THR A 361 19.243 −27.458 −69.166 1.00 29.62 C ATOM 945 C THR A 361 17.736 −25.254 −70.354 1.00 28.82 C ATOM 946 O THR A 361 18.591 −24.396 −70.588 1.00 32.86 O ATOM 947 N LEU A 362 16.754 −25.058 −69.490 1.00 19.76 N ATOM 948 CA LEU A 362 16.607 −23.793 −68.784 1.00 21.13 C ATOM 949 CB LEU A 362 15.131 −23.617 −68.431 1.00 23.70 C ATOM 950 CG LEU A 362 14.687 −22.281 −67.883 1.00 27.97 C ATOM 951 CD1 LEU A 362 14.705 −21.241 −68.991 1.00 25.88 C ATOM 952 CD2 LEU A 362 13.276 −22.445 −67.337 1.00 33.42 C ATOM 953 C LEU A 362 17.424 −23.892 −67.499 1.00 23.41 C ATOM 954 O LEU A 362 17.295 −24.874 −66.801 1.00 20.60 O ATOM 955 N THR A 363 18.265 −22.889 −67.176 1.00 17.96 N ATOM 956 CA THR A 363 19.014 −22.961 −65.901 1.00 15.19 C ATOM 957 CB THR A 363 20.538 −22.726 −66.072 1.00 18.99 C ATOM 958 OG1 THR A 363 20.756 −21.498 −66.799 1.00 18.79 O ATOM 959 CG2 THR A 363 21.197 −23.931 −66.850 1.00 23.58 C ATOM 960 C THR A 363 18.447 −21.918 −64.954 1.00 15.28 C ATOM 961 O THR A 363 18.296 −20.751 −65.342 1.00 15.07 O ATOM 962 N VAL A 364 18.061 −22.370 −63.754 1.00 16.66 N ATOM 963 CA VAL A 364 17.416 −21.511 −62.740 1.00 15.74 C ATOM 964 CB VAL A 364 15.881 −21.816 −62.556 1.00 13.40 C ATOM 965 CG1 VAL A 364 15.082 −21.387 −63.766 1.00 16.27 C ATOM 966 CG2 VAL A 364 15.612 −23.285 −62.214 1.00 13.58 C ATOM 967 C VAL A 364 18.105 −21.689 −61.392 1.00 12.50 C ATOM 968 O VAL A 364 18.622 −22.788 −61.064 1.00 13.58 O ATOM 969 N TYR A 365 18.091 −20.625 −60.589 1.00 12.72 N ATOM 970 CA TYR A 365 18.767 −20.633 −59.306 1.00 14.10 C ATOM 971 CB TYR A 365 18.817 −19.212 −58.737 1.00 14.22 C ATOM 972 CG TYR A 365 19.899 −18.354 −59.313 1.00 17.51 C ATOM 973 CD1 TYR A 365 21.257 −18.730 −59.208 1.00 15.39 C ATOM 974 CE1 TYR A 365 22.267 −17.910 −59.714 1.00 16.21 C ATOM 975 CZ TYR A 365 21.927 −16.726 −60.321 1.00 18.33 C ATOM 976 OH TYR A 365 22.920 −15.924 −60.831 1.00 19.92 O ATOM 977 CE2 TYR A 365 20.613 −16.319 −60.408 1.00 17.25 C ATOM 978 CD2 TYR A 365 19.590 −17.152 −59.928 1.00 15.49 C ATOM 979 C TYR A 365 18.027 −21.514 −58.298 1.00 13.68 C ATOM 980 O TYR A 365 18.636 −22.096 −57.390 1.00 14.00 O ATOM 981 N LYS A 366 16.701 −21.540 −53.442 1.00 14.64 N ATOM 982 CA LYS A 366 15.813 −22.158 −57.461 1.00 15.00 C ATOM 983 CB LYS A 366 15.182 −21.070 −56.571 1.00 15.61 C ATOM 984 CG LYS A 366 16.174 −20.386 −55.621 1.00 17.78 C ATOM 985 CD LYS A 366 16.349 −21.258 −54.390 1.00 17.98 C ATOM 986 CE LYS A 366 17.312 −20.672 −53.386 1.00 22.69 C ATOM 987 NZ LYS A 366 17.399 −21.604 −52.240 1.00 18.28 N ATOM 988 C LYS A 366 14.693 −22.903 −58.174 1.00 12.15 C ATOM 989 O LYS A 366 14.206 −22.458 −59.235 1.00 14.93 O ATOM 990 N ALA A 367 14.220 −23.977 −57.548 1.00 13.21 N ATOM 991 CA ALA A 367 13.081 −24.755 −58.057 1.00 14.40 C ATOM 992 CB ALA A 367 13.559 −25.833 −59.049 1.00 14.70 C ATOM 993 C ALA A 367 12.373 −25.419 −56.886 1.00 12.95 C ATOM 994 O ALA A 367 12.929 −25.503 −55.758 1.00 17.70 O ATOM 995 N SER A 368 11.180 −25.919 −57.145 1.00 14.33 N ATOM 996 CA SER A 368 10.317 −26.439 −56.067 1.00 15.19 C ATOM 997 CB SER A 368 9.220 −25.394 −55.730 1.00 14.05 C ATOM 998 OG SER A 368 8.512 −25.019 −56.909 1.00 19.52 O ATOM 999 C SER A 368 9.637 −27.722 −56.558 1.00 14.51 C ATOM 1000 O SER A 368 9.480 −27.925 −57.785 1.00 13.03 O ATOM 1001 N ASN A 369 9.200 −28.550 −55.610 1.00 14.24 N ATOM 1002 CA ASN A 369 8.319 −29.679 −55.909 1.00 15.26 C ATOM 1003 CB ASN A 369 7.018 −29.180 −56.549 1.00 13.90 C ATOM 1004 CG ASN A 369 6.245 −28.226 −55.622 1.00 19.57 C ATOM 1005 OD1 ASN A 369 5.741 −27.178 −56.047 1.00 21.87 O ATOM 1006 ND2 ASN A 369 6.207 −28.563 −54.347 1.00 17.45 N ATOM 1007 C ASN A 369 9.000 −30.743 −56.767 1.00 18.36 C ATOM 1008 O ASN A 369 8.337 −31.496 −57.505 1.00 18.33 O ATOM 1009 N LEU A 370 10.309 −30.851 −56.608 1.00 15.47 N ATOM 1010 CA LEU A 370 11.077 −31.893 −57.259 1.00 17.84 C ATOM 1011 CB LEU A 370 12.217 −31.280 −58.085 1.00 15.67 C ATOM 1012 CG LEU A 370 11.822 −30.431 −59.300 1.00 16.95 C ATOM 1013 CD1 LEU A 370 13.039 −29.687 −59.845 1.00 18.12 C ATOM 1014 CD2 LEU A 370 11.231 −31.288 −60.408 1.00 16.77 C ATOM 1015 C LEU A 370 11.645 −32.827 −56.220 1.00 21.02 C ATOM 1016 O LEU A 370 12.073 −32.391 −55.140 1.00 21.26 O ATOM 1017 N ASN A 371 11.650 −34.106 −56.554 1.00 18.65 N ATOM 1018 CA ASN A 371 12.345 −35.124 −55.786 1.00 19.11 C ATOM 1019 CB ASN A 371 11.456 −36.378 −55.660 1.00 20.40 C ATOM 1020 CG ASN A 371 10.301 −36.176 −54.702 1.00 25.22 C ATOM 1021 OD1 ASN A 371 10.409 −35.415 −53.724 1.00 32.27 O ATOM 1022 ND2 ASN A 371 9.184 −36.841 −54.973 1.00 27.28 N ATOM 1023 C ASN A 371 13.608 −35.504 −56.480 1.00 19.60 C ATOM 1024 O ASN A 371 13.627 −35.676 −57.692 1.00 20.13 O ATOM 1025 N LEU A 372 14.671 −35.670 −55.711 1.00 19.95 N ATOM 1026 CA LEU A 372 15.972 −36.041 −56.266 1.00 20.70 C ATOM 1027 CB LEU A 372 17.095 −35.384 −55.469 1.00 26.05 C ATOM 1028 CG LEU A 372 17.112 −33.836 −55.401 1.00 28.71 C ATOM 1029 CD1 LEU A 372 18.169 −33.369 −54.398 1.00 37.57 C ATOM 1030 CD2 LEU A 372 17.371 −33.203 −56.763 1.00 28.90 C ATOM 1031 C LEU A 372 16.127 −37.540 −56.218 1.00 27.21 C ATOM 1032 O LEU A 372 15.786 −38.172 −55.207 1.00 22.80 O ATOM 1033 N ILE A 373 16.661 −38.105 −57.298 1.00 23.66 N ATOM 1034 CA ILE A 373 16.835 −39.539 −57.410 1.00 26.08 C ATOM 1035 CB ILE A 373 16.175 −40.081 −58.693 1.00 29.06 C ATOM 1036 CG1 ILE A 373 14.693 −39.687 −58.754 1.00 26.65 C ATOM 1037 CD1 ILE A 373 13.858 −40.236 −57.606 1.00 25.01 C ATOM 1038 CG2 ILE A 373 16.323 −41.608 −58.781 1.00 31.87 C ATOM 1039 C ILE A 373 18.327 −39.863 −57.465 1.00 29.50 C ATOM 1040 O ILE A 373 19.039 −39.386 −58.361 1.00 27.45 O ATOM 1041 N GLY A 374 18.798 −40.662 −56.507 1.00 33.07 N ATOM 1042 CA GLY A 374 20.178 −41.136 −56.533 1.00 33.62 C ATOM 1043 C GLY A 374 21.157 −40.100 −56.033 1.00 35.52 C ATOM 1044 O GLY A 374 20.773 −39.168 −55.316 1.00 34.59 O ATOM 1045 N ARG A 375 22.429 −40.247 −56.435 1.00 31.82 N ATOM 1046 CA ARG A 375 23.540 −39.471 −55.859 1.00 32.45 C ATOM 1047 CB ARG A 375 24.585 −40.405 −55.217 1.00 37.47 C ATOM 1048 CG ARG A 375 24.003 −41.494 −54.300 1.00 47.10 C ATOM 1049 CD ARG A 375 25.049 −42.109 −53.370 1.00 52.40 C ATOM 1050 NE ARG A 375 26.408 −41.612 −53.628 1.00 77.74 N ATOM 1051 CZ ARG A 375 27.255 −42.132 −54.519 1.00 75.83 C ATOM 1052 NH1 ARG A 375 26.899 −43.175 −55.262 1.00 69.90 N ATOM 1053 NH2 ARG A 375 28.457 −41.595 −54.676 1.00 81.71 N ATOM 1054 C ARG A 375 24.198 −38.668 −56.966 1.00 30.05 C ATOM 1055 O ARG A 375 24.100 −39.043 −58.132 1.00 30.89 O ATOM 1056 N PRO A 376 24.880 −37.561 −56.619 1.00 25.07 N ATOM 1057 CA PRO A 376 25.445 −36.742 −57.711 1.00 23.23 C ATOM 1053 CB PRO A 376 26.062 −35.542 −56.972 1.00 25.63 C ATOM 1059 CG PRO A 376 25.348 −35.500 −55.653 1.00 31.07 C ATOM 1060 CD PRO A 376 25.091 −36.936 −55.300 1.00 31.31 C ATOM 1061 C PRO A 376 26.494 −37.477 −58.553 1.00 27.82 C ATOM 1062 O PRO A 376 27.211 −38.334 −58.034 1.00 33.45 O ATOM 1063 N SER A 377 26.548 −37.169 −59.850 1.00 24.06 N ATOM 1064 CA SER A 377 27.555 −37.751 −60.746 1.00 24.41 C ATOM 1065 CB SER A 377 26.933 −38.851 −61.642 1.00 24.09 C ATOM 1066 OG SER A 377 27.849 −39.241 −62.686 1.00 28.67 O ATOM 1067 C SER A 377 28.152 −36.679 −61.617 1.00 25.29 C ATOM 1068 O SER A 377 27.441 −35.761 −62.089 1.00 24.22 O ATOM 1069 N THR A 378 29.444 −36.787 −61.887 1.00 21.39 N ATOM 1070 CA THR A 378 30.069 −35.875 −62.848 1.00 22.60 C ATOM 1071 CB THR A 378 31.495 −35.499 −62.411 1.00 28.47 C ATOM 1072 OG1 THR A 378 32.250 −36.696 −62.263 1.00 26.46 O ATOM 1073 CG2 THR A 378 31.467 −34.772 −61.077 1.00 25.64 C ATOM 1074 C THR A 378 30.156 −36.442 −64.267 1.00 20.34 C ATOM 1075 O THR A 378 30.633 −35.751 −65.181 1.00 23.40 O ATOM 1076 N VAL A 379 29.734 −37.699 −64.443 1.00 25.52 N ATOM 1077 CA VAL A 379 29.851 −38.369 −65.738 1.00 26.25 C ATOM 1078 CB VAL A 379 29.410 −39.853 −65.656 1.00 25.49 C ATOM 1079 CG1 VAL A 379 29.529 −40.512 −67.021 1.00 36.68 C ATOM 1080 CG2 VAL A 379 30.271 −40.599 −64.649 1.00 32.31 C ATOM 1081 C VAL A 379 29.041 −37.635 −66.806 1.00 24.36 C ATOM 1082 O VAL A 379 27.870 −37.394 −66.623 1.00 27.01 O ATOM 1083 N HIS A 380 29.693 −37.260 −67.900 1.00 21.88 N ATOM 1084 CA HIS A 380 29.053 −36.523 −69.009 1.00 26.88 C ATOM 1085 CB HIS A 380 27.998 −37.406 −69.743 1.00 25.41 C ATOM 1086 CG HIS A 380 28.561 −38.701 −70.313 1.00 27.07 C ATOM 1087 ND1 HIS A 380 29.619 −38.727 −71.168 1.00 30.51 N ATOM 1088 CE1 HIS A 380 29.888 −40.005 −71.499 1.00 27.87 C ATOM 1089 NE2 HIS A 380 29.011 −40.801 −70.859 1.00 27.67 N ATOM 1090 CD2 HIS A 380 28.164 −40.033 −70.140 1.00 27.53 C ATOM 1091 C HIS A 380 28.436 −35.166 −68.641 1.00 25.06 C ATOM 1092 O HIS A 380 27.648 −34.615 −69.414 1.00 23.98 O ATOM 1093 N SER A 381 28.782 −34.617 −67.473 1.00 25.37 N ATOM 1094 CA SER A 381 28.188 −33.314 −67.045 1.00 23.77 C ATOM 1095 CB SER A 381 28.864 −32.775 −65.791 1.00 25.06 C ATOM 1096 OG SER A 381 28.205 −31.577 −65.394 1.00 21.03 O ATOM 1097 C SER A 381 28.231 −32.249 −68.117 1.00 21.38 C ATOM 1098 O SER A 381 29.288 −31.959 −68.684 1.00 21.51 O ATOM 1099 N TRP A 382 27.084 −31.630 −68.386 1.00 18.44 N ATOM 1100 CA TRP A 382 27.026 −30.557 −69.347 1.00 20.60 C ATOM 1101 CB TRP A 382 25.608 −30.281 −69.796 1.00 23.63 C ATOM 1102 CG TRP A 382 24.904 −31.474 −70.389 1.00 23.49 C ATOM 1103 CD1 TRP A 382 25.452 −32.460 −71.216 1.00 26.82 C ATOM 1104 NE1 TRP A 382 24.489 −33.401 −71.555 1.00 21.24 N ATOM 1105 CE2 TRP A 382 23.296 −33.094 −70.940 1.00 22.49 C ATOM 1106 CD2 TRP A 382 23.501 −31.851 −70.197 1.00 24.48 C ATOM 1107 CE3 TRP A 382 22.427 −31.306 −69.476 1.00 26.68 C ATOM 1108 CZ3 TRP A 382 21.187 −31.967 −69.513 1.00 22.77 C ATOM 1109 CH2 TRP A 382 21.005 −33.145 −70.267 1.00 24.87 C ATOM 1110 CZ2 TRP A 382 22.065 −33.737 −70.974 1.00 27.21 C ATOM 1111 C TRP A 382 27.621 −29.293 −68.832 1.00 22.03 C ATOM 1112 O TRP A 382 27.810 −28.362 −69.593 1.00 22.11 O ATOM 1113 N PHE A 383 27.845 −29.235 −67.522 1.00 22.34 N ATOM 1114 CA PHE A 383 28.417 −28.009 −66.868 1.00 20.86 C ATOM 1115 CB PHE A 383 27.347 −27.327 −65.992 1.00 19.63 C ATOM 1116 CG PHE A 383 26.107 −26.956 −66.754 1.00 20.66 C ATOM 1117 CD1 PHE A 383 26.113 −25.895 −67.624 1.00 22.70 C ATOM 1118 CE1 PHE A 383 24.969 −25.558 −68.345 1.00 33.06 C ATOM 1119 CZ PHE A 383 23.813 −26.325 −68.216 1.00 25.51 C ATOM 1120 CE2 PHE A 383 23.817 −27.418 −67.367 1.00 22.05 C ATOM 1121 CD2 PHE A 383 24.953 −27.732 −66.649 1.00 19.30 C ATOM 1122 C PHE A 383 29.657 −28.378 −66.059 1.00 19.37 C ATOM 1123 O PHE A 333 29.573 −28.720 −64.903 1.00 20.96 O ATOM 1124 N PRO A 384 30.828 −28.345 −66.703 1.00 26.97 N ATOM 1125 CA PRO A 384 32.078 −28.795 −66.056 1.00 30.77 C ATOM 1126 CB PRO A 334 33.167 −28.354 −67.060 1.00 30.95 C ATOM 1127 CG PRO A 384 32.479 −28.385 −68.372 1.00 37.59 C ATOM 1128 CD PRO A 384 31.032 −27.986 −68.120 1.00 26.71 C ATOM 1129 C PRO A 384 32.276 −28.100 −64.719 1.00 25.39 C ATOM 1130 O PRO A 384 32.042 −26.910 −64.613 1.00 27.70 O ATOM 1131 N GLY A 335 32.637 −28.856 −63.695 1.00 24.10 N ATOM 1132 CA GLY A 385 32.723 −28.301 −62.375 1.00 28.87 C ATOM 1133 C GLY A 385 31.483 −28.583 −61.548 1.00 28.15 C ATOM 1134 O GLY A 385 31.479 −28.356 −60.341 1.00 25.07 O ATOM 1135 N TYR A 386 30.412 −29.063 −62.206 1.00 23.50 N ATOM 1136 CA TYR A 386 29.186 −29.473 −61.494 1.00 22.79 C ATOM 1137 CB TYR A 386 27.987 −28.644 −61.986 1.00 20.38 C ATOM 1138 CG TYR A 386 28.071 −27.185 −61.612 1.00 20.82 C ATOM 1139 CD2 TYR A 336 27.472 −26.716 −60.440 1.00 19.55 C ATOM 1140 CE2 TYR A 386 27.546 −25.369 −60.086 1.00 19.57 C ATOM 1141 CZ TYR A 386 28.216 −24.474 −60.907 1.00 21.35 C ATOM 1142 OH TYR A 386 28.271 −23.134 −60.535 1.00 18.04 O ATOM 1143 CE1 TYR A 386 28.810 −24.910 −62.094 1.00 17.74 C ATOM 1144 CD1 TYR A 386 28.728 −26.260 −62.440 1.00 21.38 C ATOM 1145 C TYR A 386 28.891 −30.951 −61.715 1.00 20.73 C ATOM 1146 O TYR A 386 29.187 −31.494 −62.772 1.00 21.44 O ATOM 1147 N ALA A 387 28.337 −31.583 −60.701 1.00 22.51 N ATOM 1148 CA ALA A 387 27.762 −32.907 −60.830 1.00 22.36 C ATOM 1149 CB ALA A 387 28.143 −33.757 −59.637 1.00 22.23 C ATOM 1150 C ALA A 387 26.239 −32.784 −60.938 1.00 23.77 C ATOM 1151 O ALA A 387 25.665 −31.756 −60.579 1.00 23.94 O ATOM 1152 N TRP A 388 25.601 −33.834 −61.433 1.00 20.85 N ATOM 1153 CA TRP A 388 24.161 −33.837 −61.653 1.00 21.29 C ATOM 1154 CB TRP A 388 23.848 −33.926 −63.159 1.00 22.82 C ATOM 1155 CG TRP A 388 24.459 −35.129 −63.834 1.00 20.86 C ATOM 1156 CD1 TRP A 388 25.650 −35.185 −64.552 1.00 21.27 C ATOM 1157 NE1 TRP A 388 25.862 −36.460 −65.039 1.00 21.02 N ATOM 1158 CE2 TRP A 388 24.874 −37.289 −64.625 1.00 20.94 C ATOM 1159 CD2 TRP A 388 23.927 −36.483 −63.856 1.00 20.92 C ATOM 1160 CE3 TRP A 388 22.791 −37.093 −63.328 1.00 21.07 C ATOM 1161 CZ3 TRP A 388 22.584 −38.464 −63.579 1.00 29.65 C ATOM 1162 CH2 TRP A 388 23.510 −39.216 −64.325 1.00 24.57 C ATOM 1163 CZ2 TRP A 388 24.669 −38.637 −64.865 1.00 26.17 C ATOM 1164 C TRP A 388 23.463 −34.907 −60.863 1.00 24.28 C ATOM 1165 O TRP A 388 24.049 −35.968 −60.511 1.00 22.04 O ATOM 1166 N THR A 389 22.219 −34.617 −60.512 1.00 22.74 N ATOM 1167 CA THR A 389 21.341 −35.561 −59.861 1.00 18.08 C ATOM 1168 CB THR A 389 21.155 −35.214 −58.356 1.00 22.84 C ATOM 1169 OG1 THR A 389 22.448 −35.158 −57.705 1.00 25.75 O ATOM 1170 CG2 THR A 389 20.307 −36.246 −57.663 1.00 20.09 C ATOM 1171 C THR A 389 19.998 −35.465 −60.609 1.00 18.87 C ATOM 1172 O THR A 389 19.503 −34.360 −60.863 1.00 17.08 O ATOM 1173 N ILE A 390 19.424 −36.607 −60.988 1.00 16.95 N ATOM 1174 CA ILE A 390 18.071 −36.577 −61.618 1.00 18.27 C ATOM 1175 CB ILE A 390 17.637 −37.992 −62.078 1.00 23.37 C ATOM 1176 CG1 ILE A 390 18.577 −38.492 −63.183 1.00 23.70 C ATOM 1177 CD1 ILE A 390 18.560 −40.019 −63.336 1.00 33.13 C ATOM 1178 CG2 ILE A 390 16.193 −37.991 −62.562 1.00 23.33 C ATOM 1179 C ILE A 390 17.007 −35.936 −60.691 1.00 16.79 C ATOM 1180 O ILE A 390 16.956 −36.231 −59.470 1.00 16.80 O ATOM 1181 N ALA A 391 16.148 −35.089 −61.280 1.00 17.09 N ATOM 1182 CA ALA A 391 15.091 −34.386 −60.542 1.00 18.29 C ATOM 1183 CB ALA A 391 15.376 −32.872 −60.521 1.00 17.09 C ATOM 1184 C ALA A 391 13.750 −34.663 −61.214 1.00 19.96 C ATOM 1185 O ALA A 391 13.593 −34.428 −62.412 1.00 17.86 O ATOM 1186 N GLN A 392 12.806 −35.219 −60.465 1.00 16.58 N ATOM 1187 CA GLN A 392 11.501 −35.546 −61.034 1.00 17.64 C ATOM 1188 CB GLN A 392 11.273 −37.057 −61.035 1.00 24.45 C ATOM 1189 CG GLN A 392 11.366 −37.712 −59.683 1.00 24.08 C ATOM 1190 CD GLN A 392 11.135 −39.230 −59.775 1.00 32.39 C ATOM 1191 OE1 GLN A 392 11.665 −39.903 −60.657 1.00 28.38 O ATOM 1192 NE2 GLN A 392 10.347 −39.752 −58.871 1.00 33.11 N ATOM 1193 C GLN A 392 10.386 −34.872 −60.267 1.00 15.18 C ATOM 1194 O GLN A 392 10.527 −34.584 −59.068 1.00 14.91 O ATOM 1195 N CYS A 393 9.276 −34.627 −60.948 1.00 13.31 N ATOM 1196 CA CYS A 393 8.103 −33.991 −60.319 1.00 15.19 C ATOM 1197 CB CYS A 393 6.943 −33.848 −61.336 1.00 14.35 C ATOM 1198 SG CYS A 393 5.435 −33.133 −60.584 1.00 16.09 S ATOM 1199 C CYS A 393 7.629 −34.818 −59.116 1.00 18.29 C ATOM 1200 O CYS A 393 7.474 −36.023 −59.230 1.00 16.38 O ATOM 1201 N LYS A 394 7.400 −34.159 −57.973 1.00 15.55 N ATOM 1202 CA LYS A 394 6.950 −34.866 −56.742 1.00 18.48 C ATOM 1203 CB LYS A 394 7.007 −33.949 −55.520 1.00 18.74 C ATOM 1204 CG LYS A 394 5.807 −33.003 −55.367 1.00 19.82 C ATOM 1205 CD LYS A 394 5.871 −32.240 −54.036 1.00 23.50 C ATOM 1206 CE LYS A 394 4.638 −31.347 −53.846 1.00 24.76 C ATOM 1207 NZ LYS A 394 4.742 −30.437 −52.642 1.00 25.38 N ATOM 1208 C LYS A 394 5.565 −35.480 −56.865 1.00 17.86 C ATOM 1209 O LYS A 394 5.257 −36.433 −56.159 1.00 19.63 O ATOM 1210 N ILE A 395 4.735 −34.927 −57.754 1.00 17.80 N ATOM 1211 CA ILE A 395 3.358 −35.409 −57.947 1.00 20.98 C ATOM 1212 CB ILE A 395 2.408 −34.284 −58.397 1.00 20.30 C ATOM 1213 CG1 ILE A 395 2.338 −33.152 −57.341 1.00 21.67 C ATOM 1214 CD1 ILE A 395 1.867 −33.568 −55.961 1.00 28.19 C ATOM 1215 CG2 ILE A 395 1.024 −34.849 −58.748 1.00 22.86 C ATOM 1216 C ILE A 395 3.265 −36.578 −58.951 1.00 23.60 C ATOM 1217 O ILE A 395 2.767 −37.650 −58.609 1.00 24.21 O ATOM 1218 N CYS A 396 3.824 −36.390 −60.152 1.00 16.52 N ATOM 1219 CA CYS A 396 3.610 −37.329 −61.250 1.00 14.91 C ATOM 1220 CB CYS A 396 3.020 −36.610 −62.452 1.00 19.18 C ATOM 1221 SG CYS A 396 4.212 −35.527 −63.306 1.00 17.12 S ATOM 1222 C CYS A 396 4.836 −38.152 −61.653 1.00 19.70 C ATOM 1223 O CYS A 396 4.747 −39.029 −62.545 1.00 18.60 O ATOM 1224 N ALA A 397 5.962 −37.895 −60.960 1.00 18.51 N ATOM 1225 CA ALA A 397 7.253 −38.527 −61.225 1.00 18.99 C ATOM 1226 CB ALA A 397 7.222 −40.038 −60.907 1.00 21.26 C ATOM 1227 C ALA A 397 7.832 −38.273 −62.613 1.00 17.09 C ATOM 1228 O ALA A 397 8.748 −38.957 −63.026 1.00 17.46 O ATOM 1229 N SER A 398 7.310 −37.303 −63.342 1.00 16.46 N ATOM 1230 CA SER A 398 7.904 −36.964 −64.642 1.00 17.70 C ATOM 1231 CB SER A 398 7.061 −35.926 −65.384 1.00 20.22 C ATOM 1232 OG SER A 398 5.807 −36.483 −65.729 1.00 27.61 O ATOM 1233 C SER A 398 9.306 −36.414 −64.447 1.00 21.04 C ATOM 1234 O SER A 398 9.542 −35.611 −63.548 1.00 18.56 O ATOM 1235 N HIS A 399 10.229 −36.824 −65.305 1.00 20.73 N ATOM 1236 CA HIS A 399 11.618 −36.356 −65.214 1.00 23.98 C ATOM 1237 CB HIS A 399 12.552 −37.301 −65.980 1.00 26.36 C ATOM 1238 CG HIS A 399 12.905 −38.558 −65.222 1.00 38.61 C ATOM 1239 ND1 HIS A 399 12.082 −39.114 −64.298 1.00 37.93 N ATOM 1240 CE1 HIS A 399 12.651 −40.224 −63.803 1.00 35.70 C ATOM 1241 NE2 HIS A 399 13.837 −40.394 −64.411 1.00 38.97 N ATOM 1242 CD2 HIS A 399 14.025 −39.388 −65.293 1.00 37.44 C ATOM 1243 C HIS A 399 11.692 −34.962 −65.775 1.00 23.95 C ATOM 1244 O HIS A 399 11.474 −34.758 −66.958 1.00 26.60 O ATOM 1245 N ILE A 400 11.943 −33.976 −64.917 1.00 17.27 N ATOM 1246 CA ILE A 400 11.912 −32.570 −65.360 1.00 17.27 C ATOM 1247 CB ILE A 400 11.344 −31.628 −64.252 1.00 19.92 C ATOM 1248 CG1 ILE A 400 10.029 −32.185 −63.717 1.00 23.37 C ATOM 1249 CD1 ILE A 400 8.992 −32.393 −64.791 1.00 22.30 C ATOM 1250 CG2 ILE A 400 11.112 −30.193 −64.805 1.00 16.32 C ATOM 1251 C ILE A 400 13.325 −32.081 −65.751 1.00 15.70 C ATOM 1252 O ILE A 400 13.477 −31.209 −66.608 1.00 16.12 O ATOM 1253 N GLY A 401 14.338 −32.618 −65.084 1.00 17.30 N ATOM 1254 CA GLY A 401 15.707 −32.124 −65.280 1.00 16.35 C ATOM 1255 C GLY A 401 16.649 −32.656 −64.242 1.00 17.80 C ATOM 1256 O GLY A 401 16.549 −33.825 −63.825 1.00 18.07 O ATOM 1257 N TRP A 402 17.607 −31.813 −63.836 1.00 15.87 N ATOM 1258 CA TRP A 402 18.672 −32.244 −62.939 1.00 14.10 C ATOM 1259 CB TRP A 402 19.949 −32.590 −63.735 1.00 16.11 C ATOM 1260 CG TRP A 402 19.710 −33.668 −64.748 1.00 17.78 C ATOM 1261 CD1 TRP A 402 19.912 −35.028 −64.588 1.00 17.21 C ATOM 1262 NE1 TRP A 402 19.526 −35.709 −65.716 1.00 20.74 N ATOM 1263 CE2 TRP A 402 19.081 −34.839 −66.655 1.00 19.99 C ATOM 1264 CD2 TRP A 402 19.161 −33.506 −66.080 1.00 18.31 C ATOM 1265 CE3 TRP A 402 18.730 −32.417 −66.831 1.00 19.19 C ATOM 1266 CZ3 TRP A 402 18.216 −32.655 −68.120 1.00 22.55 C ATOM 1267 CH2 TRP A 402 18.127 −33.961 −68.640 1.00 20.63 C ATOM 1268 CZ2 TRP A 402 18.561 −35.066 −67.920 1.00 23.58 C ATOM 1269 C TRP A 402 19.019 −31.130 −62.004 1.00 15.12 C ATOM 1270 O TRP A 402 18.966 −29.957 −62.383 1.00 15.21 O ATOM 1271 N LYS A 403 19.375 −31.494 −60.785 1.00 17.30 N ATOM 1272 CA LYS A 403 20.052 −30.576 −59.875 1.00 15.95 C ATOM 1273 CB LYS A 403 19.773 −30.939 −58.442 1.00 19.03 C ATOM 1274 CG LYS A 403 20.163 −29.836 −57.442 1.00 21.17 C ATOM 1275 CD LYS A 403 20.084 −30.380 −56.012 1.00 22.22 C ATOM 1276 CE LYS A 403 20.025 −29.262 −54.973 1.00 30.25 C ATOM 1277 NZ LYS A 403 20.272 −29.871 −53.635 1.00 40.26 N ATOM 1278 C LYS A 403 21.561 −30.655 −60.121 1.00 19.31 C ATOM 1279 O LYS A 403 22.151 −31.748 −60.123 1.00 21.01 O ATOM 1280 N PHE A 404 22.174 −29.505 −60.335 1.00 14.51 N ATOM 1281 CA PHE A 404 23.620 −29.439 −60.555 1.00 16.13 C ATOM 1282 CB PHE A 404 23.927 −28.551 −61.739 1.00 16.01 C ATOM 1283 CG PHE A 404 23.694 −29.231 −63.059 1.00 20.17 C ATOM 1284 CD1 PHE A 404 24.676 −30.083 −63.597 1.00 18.44 C ATOM 1285 CE1 PHE A 404 24.441 −30.796 −64.778 1.00 20.09 C ATOM 1286 CZ PHE A 404 23.224 −30.649 −65.446 1.00 17.78 C ATOM 1287 CE2 PHE A 404 22.218 −29.833 −64.910 1.00 16.13 C ATOM 1288 CD2 PHE A 404 22.462 −29.103 −63.724 1.00 15.93 C ATOM 1289 C PHE A 404 24.257 −28.882 −59.301 1.00 19.95 C ATOM 1290 O PHE A 404 23.831 −27.831 −58.805 1.00 17.09 O ATOM 1291 N THR A 405 25.231 −29.609 −58.764 1.00 17.32 N ATOM 1292 CA THR A 405 25.909 −29.215 −57.525 1.00 20.07 C ATOM 1293 CB THR A 405 25.658 −30.281 −56.434 1.00 23.95 C ATOM 1294 OG1 THR A 405 25.926 −31.585 −56.977 1.00 28.20 O ATOM 1295 CG2 THR A 405 24.142 −30.270 −55.973 1.00 25.69 C ATOM 1296 C THR A 405 27.435 −29.017 −57.762 1.00 23.38 C ATOM 1297 O THR A 405 28.080 −29.831 −58.447 1.00 22.36 O ATOM 1298 N ALA A 406 27.986 −27.898 −57.262 1.00 21.03 N ATOM 1299 CA ALA A 406 29.404 −27.538 −57.519 1.00 23.57 C ATOM 1300 CB ALA A 406 29.710 −26.147 −56.932 1.00 22.59 C ATOM 1301 C ALA A 406 30.333 −28.568 −56.907 1.00 24.15 C ATOM 1302 O ALA A 406 30.087 −29.038 −55.833 1.00 25.53 O ATOM 1303 N THR A 407 31.402 −28.922 −57.609 1.00 28.23 N ATOM 1304 CA THR A 407 32.384 −29.843 −57.039 1.00 29.91 C ATOM 1305 CB THR A 407 33.084 −30.689 −58.128 1.00 25.99 C ATOM 1306 OG1 THR A 407 33.745 −29.819 −59.059 1.00 28.89 O ATOM 1307 CG2 THR A 407 32.066 −31.527 −58.874 1.00 26.23 C ATOM 1308 C THR A 407 33.435 −29.101 −56.177 1.00 36.18 C ATOM 1309 O THR A 407 34.094 −29.717 −55.370 1.00 34.56 O ATOM 1310 N LYS A 408 33.558 −27.780 −56.352 1.00 29.09 N ATOM 1311 CA LYS A 408 34.460 −26.958 −55.515 1.00 37.57 C ATOM 1312 CB LYS A 408 35.575 −26.332 −56.369 1.00 34.23 C ATOM 1313 CG LYS A 408 36.430 −27.332 −57.146 1.00 39.89 C ATOM 1314 CD LYS A 408 37.785 −26.732 −57.514 1.00 49.23 C ATOM 1315 CE LYS A 408 37.652 −25.438 −58.312 1.00 55.68 C ATOM 1316 NZ LYS A 408 37.440 −25.692 −59.765 1.00 54.21 N ATOM 1317 C LYS A 408 33.722 −25.836 −54.780 1.00 34.85 C ATOM 1318 O LYS A 408 32.818 −25.197 −55.333 1.00 25.69 O ATOM 1319 N LYS A 409 34.176 −25.524 −53.573 1.00 31.99 N ATOM 1320 CA LYS A 409 33.569 −24.451 −52.792 1.00 26.25 C ATOM 1321 CB LYS A 409 34.125 −24.443 −51.350 1.00 32.85 C ATOM 1322 CG LYS A 409 33.475 −25.462 −50.426 1.00 40.79 C ATOM 1323 CD LYS A 409 32.471 −24.806 −49.499 1.00 50.12 C ATOM 1324 CE LYS A 409 31.959 −25.792 −48.455 1.00 55.36 C ATOM 1325 NZ LYS A 409 30.861 −26.650 −48.998 1.00 53.81 N ATOM 1326 C LYS A 409 33.687 −23.054 −53.409 1.00 24.07 C ATOM 1327 O LYS A 409 32.896 −22.166 −53.088 1.00 29.10 O ATOM 1328 N ASP A 410 34.683 −22.820 −54.245 1.00 26.10 N ATOM 1329 CA ASP A 410 34.947 −21.411 −54.633 1.00 31.13 C ATOM 1330 CB ASP A 410 36.424 −21.194 −54.985 1.00 43.91 C ATOM 1331 CG ASP A 410 36.894 −22.092 −56.120 1.00 46.43 C ATOM 1332 OD1 ASP A 410 36.042 −22.719 −56.793 1.00 47.71 O ATOM 1333 OD2 ASP A 410 38.118 −22.160 −56.347 1.00 62.90 O ATOM 1334 C ASP A 410 34.038 −20.932 −55.782 1.00 34.75 C ATOM 1335 O ASP A 410 34.136 −19.780 −56.226 1.00 33.89 O ATOM 1336 N MET A 411 33.156 −21.833 −56.247 1.00 30.59 N ATOM 1337 CA MET A 411 32.273 −21.580 −57.393 1.00 31.59 C ATOM 1338 CB MET A 411 31.923 −22.917 −58.078 1.00 25.09 C ATOM 1339 CG MET A 411 33.155 −23.553 −58.683 1.00 38.34 C ATOM 1340 SD MET A 411 32.886 −25.110 −59.523 1.00 35.70 S ATOM 1341 CE MET A 411 32.345 −26.148 −58.205 1.00 40.76 C ATOM 1342 C MET A 411 30.986 −20.865 −56.983 1.00 29.05 C ATOM 1343 O MET A 411 30.542 −20.984 −55.849 1.00 24.90 O ATOM 1344 N SER A 412 30.412 −20.101 −57.912 1.00 26.31 N ATOM 1345 CA SER A 412 29.044 −19.577 −57.756 1.00 23.18 C ATOM 1346 CB SER A 412 29.028 −18.075 −57.478 1.00 25.95 C ATOM 1347 OG SER A 412 29.735 −17.356 −58.485 1.00 33.06 O ATOM 1348 C SER A 412 28.228 −19.940 −58.981 1.00 18.92 C ATOM 1349 O SER A 412 28.699 −19.686 −60.092 1.00 19.11 O ATOM 1350 N PRO A 413 26.914 −20.050 −58.790 1.00 19.00 N ATOM 1351 CA PRO A 413 26.284 −20.718 −57.630 1.00 16.35 C ATOM 1352 CB PRO A 413 24.795 −20.776 −58.039 1.00 16.81 C ATOM 1353 CG PRO A 413 24.848 −21.037 −59.512 1.00 15.99 C ATOM 1354 CD PRO A 413 26.143 −20.319 −60.032 1.00 15.71 C ATOM 1355 C PRO A 413 26.826 −22.093 −57.201 1.00 17.48 C ATOM 1356 O PRO A 413 27.332 −22.842 −58.016 1.00 17.78 O ATOM 1357 N GLN A 414 26.698 −22.419 −55.924 1.00 16.45 N ATOM 1358 CA GLN A 414 27.085 −23.757 −55.452 1.00 16.16 C ATOM 1359 CB GLN A 414 27.118 −23.771 −53.908 1.00 20.14 C ATOM 1360 CG GLN A 414 28.411 −23.115 −53.370 1.00 17.68 C ATOM 1361 CD GLN A 414 29.612 −23.952 −53.711 1.00 19.82 C ATOM 1362 OE1 GLN A 414 30.433 −23.588 −54.569 1.00 24.32 O ATOM 1363 NE2 GLN A 414 29.682 −25.106 −53.121 1.00 17.48 N ATOM 1364 C GLN A 414 26.123 −24.845 −55.986 1.00 15.39 C ATOM 1365 O GLN A 414 26.474 −26.043 −56.031 1.00 19.71 O ATOM 1366 N LYS A 415 24.926 −24.425 −56.374 1.00 15.24 N ATOM 1367 CA LYS A 415 24.011 −25.317 −57.068 1.00 17.66 C ATOM 1368 CB LYS A 415 23.345 −26.277 −56.088 1.00 19.03 C ATOM 1369 CG LYS A 415 22.389 −25.609 −55.129 1.00 23.48 C ATOM 1370 CD LYS A 415 21.026 −25.483 −55.779 1.00 29.23 C ATOM 1371 CE LYS A 415 19.980 −25.059 −54.757 1.00 36.87 C ATOM 1372 NZ LYS A 415 20.289 −23.745 −54.117 1.00 34.89 N ATOM 1373 C LYS A 415 22.996 −24.562 −57.903 1.00 14.85 C ATOM 1374 O LYS A 415 22.779 −23.344 −57.721 1.00 14.11 O ATOM 1375 N PHE A 416 22.423 −25.260 −58.882 1.00 14.03 N ATOM 1376 CA PHE A 416 21.351 −24.676 −59.668 1.00 12.36 C ATOM 1377 CB PHE A 416 21.887 −23.714 −60.771 1.00 14.50 C ATOM 1378 CG PHE A 416 22.752 −24.396 −61.806 1.00 14.79 C ATOM 1379 CD2 PHE A 416 22.197 −24.879 −62.992 1.00 17.15 C ATOM 1380 CE2 PHE A 416 22.996 −25.493 −63.946 1.00 17.56 C ATOM 1381 CZ PHE A 416 24.343 −25.665 −63.713 1.00 20.09 C ATOM 1382 CE1 PHE A 416 24.916 −25.203 −62.519 1.00 16.98 C ATOM 1383 CD1 PHE A 416 24.116 −24.588 −61.574 1.00 18.98 C ATOM 1384 C PHE A 416 20.600 −25.853 −60.264 1.00 12.59 C ATOM 1385 O PHE A 416 20.925 −27.009 −59.979 1.00 15.60 O ATOM 1386 N TRP A 417 19.574 −25.559 −61.035 1.00 14.09 N ATOM 1387 CA TRP A 417 18.785 −26.607 −61.686 1.00 13.27 C ATOM 1388 CB TRP A 417 17.335 −26.496 −61.243 1.00 14.58 C ATOM 1389 CG TRP A 417 17.171 −26.569 −59.755 1.00 14.33 C ATOM 1390 CD1 TRP A 417 17.294 −25.515 −58.823 1.00 14.78 C ATOM 1391 NE1 TRP A 417 17.125 −25.987 −57.546 1.00 16.20 N ATOM 1392 CE2 TRP A 417 16.851 −27.315 −57.570 1.00 17.92 C ATOM 1393 CD2 TRP A 417 16.899 −27.747 −58.975 1.00 16.73 C ATOM 1394 CE3 TRP A 417 16.682 −29.099 −59.284 1.00 17.17 C ATOM 1395 CZ3 TRP A 417 16.418 −29.994 −58.234 1.00 22.73 C ATOM 1396 CH2 TRP A 417 16.373 −29.556 −56.882 1.00 21.81 C ATOM 1397 CZ2 TRP A 417 16.590 −28.199 −56.535 1.00 19.90 C ATOM 1398 C TRP A 417 18.844 −26.414 −63.164 1.00 14.40 C ATOM 1399 O TRP A 417 18.699 −25.294 −63.647 1.00 16.44 O ATOM 1400 N GLY A 418 18.989 −27.525 −63.902 1.00 13.65 N ATOM 1401 CA GLY A 418 18.917 −27.497 −65.376 1.00 14.90 C ATOM 1402 C GLY A 418 17.683 −28.297 −65.778 1.00 14.31 C ATOM 1403 O GLY A 418 17.579 −29.475 −65.468 1.00 16.37 O ATOM 1404 N LEU A 419 16.717 −27.614 −66.366 1.00 16.42 N ATOM 1405 CA LEU A 419 15.388 −28.178 −66.578 1.00 13.55 C ATOM 1406 CB LEU A 419 14.322 −27.333 −65.896 1.00 15.25 C ATOM 1407 CG LEU A 419 14.547 −27.012 −64.404 1.00 15.95 C ATOM 1408 CD1 LEU A 419 13.413 −26.117 −63.922 1.00 18.96 C ATOM 1409 CD2 LEU A 419 14.600 −28.300 −63.584 1.00 15.01 C ATOM 1410 C LEU A 419 15.092 −28.252 −68.059 1.00 15.68 C ATOM 1411 O LEU A 419 15.370 −27.329 −68.809 1.00 15.62 O ATOM 1412 N THR A 420 14.532 −29.373 −68.467 1.00 18.21 N ATOM 1413 CA THR A 420 14.182 −29.592 −69.885 1.00 17.19 C ATOM 1414 CB THR A 420 13.827 −31.079 −70.074 1.00 16.08 C ATOM 1415 OG1 THR A 420 14.934 −31.854 −69.645 1.00 17.97 O ATOM 1416 CG2 THR A 420 13.519 −31.411 −71.576 1.00 21.47 C ATOM 1417 C THR A 420 12.978 −28.751 −70.186 1.00 15.49 C ATOM 1418 O THR A 420 11.923 −28.970 −69.610 1.00 17.29 O ATOM 1419 N ARG A 421 13.116 −27.790 −71.105 1.00 14.83 N ATOM 1420 CA ARG A 421 12.081 −26.763 −71.312 1.00 20.90 C ATOM 1421 CB ARG A 421 12.505 −25.763 −72.394 1.00 25.72 C ATOM 1422 CG ARG A 421 13.530 −24.738 −71.955 1.00 35.74 C ATOM 1423 CD ARG A 421 13.908 −23.816 −73.127 1.00 47.49 C ATOM 1424 NE ARG A 421 15.140 −23.066 −72.854 1.00 49.32 N ATOM 1425 CZ ARG A 421 15.185 −21.771 −72.554 1.00 59.92 C ATOM 1426 NH1 ARG A 421 14.064 −21.051 −72.511 1.00 66.35 N ATOM 1427 NH2 ARG A 421 16.358 −21.187 −72.309 1.00 55.67 N ATOM 1428 C ARG A 421 10.749 −27.388 −71.744 1.00 19.86 C ATOM 1429 O ARG A 421 9.684 −26.887 −71.421 1.00 17.71 O ATOM 1430 N SER A 422 10.834 −28.477 −72.494 1.00 17.52 N ATOM 1431 CA SER A 422 9.622 −29.081 −73.047 1.00 22.34 C ATOM 1432 CB SER A 422 9.972 −30.022 −74.214 1.00 23.06 C ATOM 1433 OG SER A 422 10.776 −31.082 −73.767 1.00 23.61 O ATOM 1434 C SER A 422 8.832 −29.825 −71.968 1.00 19.92 C ATOM 1435 O SER A 422 7.699 −30.237 −72.209 1.00 21.55 O ATOM 1436 N ALA A 423 9.454 −30.027 −70.787 1.00 18.29 N ATOM 1437 CA ALA A 423 8.777 −30.667 −69.645 1.00 17.59 C ATOM 1438 CB ALA A 423 9.783 −31.363 −68.726 1.00 17.38 C ATOM 1439 C ALA A 423 7.940 −29.675 −68.847 1.00 17.51 C ATOM 1440 O ALA A 423 7.285 −30.051 −67.856 1.00 16.65 O ATOM 1441 N LEU A 424 7.982 −28.405 −69.251 1.00 14.88 N ATOM 1442 CA LEU A 424 7.302 −27.332 −68.517 1.00 16.25 C ATOM 1443 CB LEU A 424 8.327 −26.333 −67.974 1.00 15.98 C ATOM 1444 CG LEU A 424 9.431 −26.917 −67.082 1.00 19.37 C ATOM 1445 CD1 LEU A 424 10.536 −25.873 −66.914 1.00 22.31 C ATOM 1446 CD2 LEU A 424 8.859 −27.347 −65.714 1.00 19.49 C ATOM 1447 C LEU A 424 6.255 −26.597 −69.356 1.00 20.91 C ATOM 1448 O LEU A 424 6.382 −26.498 −70.589 1.00 18.67 O ATOM 1449 N LEU A 425 5.259 −26.025 −68.669 1.00 20.30 N ATOM 1450 CA LEU A 425 4.191 −25.232 −69.319 1.00 24.52 C ATOM 1451 CB LEU A 425 2.832 −25.809 −68.954 1.00 31.62 C ATOM 1452 CG LEU A 425 1.754 −26.121 −69.989 1.00 49.01 C ATOM 1453 CD1 LEU A 425 2.319 −26.800 −71.229 1.00 41.11 C ATOM 1454 CD2 LEU A 425 0.693 −26.994 −69.326 1.00 37.22 C ATOM 1455 C LEU A 425 4.320 −23.817 −68.779 1.00 31.26 C ATOM 1456 O LEU A 425 4.498 −23.673 −67.554 1.00 26.55 O ATOM 1457 N PRO A 426 3.829 −22.831 −69.571 1.00 38.63 N ATOM 1458 CA PRO A 426 4.472 −22.132 −70.665 1.00 44.78 C ATOM 1459 CB PRO A 426 4.778 −20.753 −70.066 1.00 39.91 C ATOM 1460 CG PRO A 426 3.697 −20.563 −69.031 1.00 47.03 C ATOM 1461 CD PRO A 426 2.972 −21.886 −68.836 1.00 47.91 C ATOM 1462 C PRO A 426 5.713 −22.854 −71.207 1.00 32.51 C ATOM 1463 O PRO A 426 6.730 −22.941 −70.518 1.00 45.29 O ATOM 1464 N THR B 321 67.510 −54.988 −61.608 1.00 50.15 N ATOM 1465 CA THR B 321 66.120 −54.688 −62.057 1.00 45.53 C ATOM 1466 CB THR B 321 65.100 −55.503 −61.254 1.00 47.96 C ATOM 1467 OG1 THR B 321 65.342 −55.316 −59.859 1.00 46.61 O ATOM 1468 CG2 THR B 321 65.181 −57.010 −61.607 1.00 53.71 C ATOM 1469 C THR B 321 65.799 −53.188 −61.895 1.00 39.43 C ATOM 1470 O THR B 321 64.657 −52.773 −62.075 1.00 34.49 O ATOM 1471 N SER B 322 66.823 −52.391 −61.581 1.00 36.88 N ATOM 1472 CA SER B 322 66.637 −51.033 −61.064 1.00 29.11 C ATOM 1473 CB SER B 322 67.823 −50.617 −60.177 1.00 36.22 C ATOM 1474 OG SER B 322 67.703 −51.173 −58.884 1.00 43.63 O ATOM 1475 C SER B 322 66.438 −49.999 −62.147 1.00 30.62 C ATOM 1476 O SER B 322 67.098 −50.025 −63.172 1.00 29.43 O ATOM 1477 N LEU B 323 65.499 −49.091 −61.914 1.00 26.36 N ATOM 1478 CA LEU B 323 65.290 −47.953 −62.808 1.00 27.16 C ATOM 1479 CB LEU B 323 63.846 −47.929 −63.337 1.00 24.04 C ATOM 1480 CG LEU B 323 63.403 −49.230 −64.057 1.00 28.53 C ATOM 1481 CD1 LEU B 323 61.917 −49.184 −64.406 1.00 28.53 C ATOM 1482 CD2 LEU B 323 64.224 −49.482 −65.305 1.00 28.81 C ATOM 1483 C LEU B 323 65.605 −46.706 −62.016 1.00 24.54 C ATOM 1484 O LEU B 323 64.988 −46.443 −60.976 1.00 23.32 O ATOM 1485 N CYS B 324 66.595 −45.953 −62.494 1.00 23.12 N ATOM 1486 CA CYS B 324 67.134 −44.818 −61.774 1.00 22.61 C ATOM 1487 CB CYS B 324 68.659 −44.989 −61.582 1.00 25.17 C ATOM 1488 SG CYS B 324 69.079 −46.490 −60.692 1.00 34.87 S ATOM 1489 C CYS B 324 66.864 −43.544 −62.523 1.00 24.14 C ATOM 1490 O CYS B 324 66.644 −43.563 −63.732 1.00 23.60 O ATOM 1491 N CYS B 325 66.818 −42.440 −61.789 1.00 21.75 N ATOM 1492 CA CYS B 325 66.672 −41.106 −62.384 1.00 24.00 C ATOM 1493 CB CYS B 325 66.868 −40.054 −61.298 1.00 26.44 C ATOM 1494 SG CYS B 325 66.820 −38.357 −61.899 1.00 23.82 S ATOM 1495 C CYS B 325 67.733 −40.898 −63.467 1.00 26.57 C ATOM 1496 O CYS B 325 68.918 −41.069 −63.209 1.00 29.43 O ATOM 1497 N LYS B 326 67.318 −40.575 −64.682 1.00 24.89 N ATOM 1498 CA LYS B 326 68.298 −40.492 −65.766 1.00 32.55 C ATOM 1499 CB LYS B 326 67.627 −40.522 −67.130 1.00 29.78 C ATOM 1500 CG LYS B 326 68.610 −40.427 −68.307 1.00 33.05 C ATOM 1501 CD LYS B 326 67.896 −40.593 −69.626 1.00 37.12 C ATOM 1502 CE LYS B 326 67.481 −39.246 −70.192 1.00 49.68 C ATOM 1503 NZ LYS B 326 66.570 −39.387 −71.373 1.00 57.66 N ATOM 1504 C LYS B 326 69.149 −39.228 −65.607 1.00 33.07 C ATOM 1505 O LYS B 326 70.324 −39.221 −65.946 1.00 31.21 O ATOM 1506 N GLN B 327 68.538 −38.183 −65.060 1.00 30.41 N ATOM 1507 CA GLN B 327 69.207 −36.897 −64.880 1.00 32.29 C ATOM 1508 CB GLN B 327 68.226 −35.832 −64.421 1.00 30.48 C ATOM 1509 CG GLN B 327 68.890 −34.503 −64.072 1.00 37.69 C ATOM 1510 CD GLN B 327 67.985 −33.318 −64.282 1.00 34.33 C ATOM 1511 OE1 GLN B 327 67.464 −32.744 −63.338 1.00 41.08 O ATOM 1512 NE2 GLN B 327 67.809 −32.938 −65.519 1.00 37.96 N ATOM 1513 C GLN B 327 70.414 −36.963 −63.937 1.00 37.97 C ATOM 1514 O GLN B 327 71.521 −36.586 −64.336 1.00 27.33 O ATOM 1515 N CYS B 328 70.206 −37.452 −62.704 1.00 28.79 N ATOM 1516 CA CYS B 328 71.290 −37.465 −61.688 1.00 29.66 C ATOM 1517 CB CYS B 328 70.839 −36.801 −60.384 1.00 35.67 C ATOM 1518 SG CYS B 328 69.660 −37.749 −59.343 1.00 28.53 S ATOM 1519 C CYS B 328 71.897 −38.855 −61.436 1.00 34.59 C ATOM 1520 O CYS B 328 72.986 −38.970 −60.874 1.00 33.18 O ATOM 1521 N GLN B 329 71.193 −39.901 −61.870 1.00 29.14 N ATOM 1522 CA GLN B 329 71.597 −41.306 −61.623 1.00 29.80 C ATOM 1523 CB GLN B 329 72.766 −41.727 −62.527 1.00 33.43 C ATOM 1524 CG GLN B 329 72.418 −41.827 −63.997 1.00 41.84 C ATOM 1525 CD GLN B 329 73.593 −42.298 −64.827 1.00 44.44 C ATOM 1526 OE1 GLN B 329 74.238 −41.508 −65.496 1.00 47.55 O ATOM 1527 NE2 GLN B 329 73.897 −43.592 −64.751 1.00 38.10 N ATOM 1528 C GLN B 329 71.906 −41.671 −60.167 1.00 26.74 C ATOM 1529 O GLN B 329 72.498 −42.715 −59.900 1.00 30.24 O ATOM 1530 N GLU B 330 71.480 −40.843 −59.233 1.00 24.72 N ATOM 1531 CA GLU B 330 71.726 −41.109 −57.816 1.00 27.80 C ATOM 1532 CB GLU B 330 71.675 −39.819 −57.013 1.00 26.00 C ATOM 1533 CG GLU B 330 72.851 −38.875 −57.257 1.00 32.21 C ATOM 1534 CD GLU B 330 74.040 −39.132 −56.341 1.00 43.50 C ATOM 1535 OE1 GLU B 330 73.977 −40.057 −55.487 1.00 40.85 O ATOM 1536 OE2 GLU B 330 75.055 −38.403 −56.480 1.00 39.44 O ATOM 1537 C GLU B 330 70.676 −42.057 −57.252 1.00 32.46 C ATOM 1538 O GLU B 330 70.978 −42.896 −56.398 1.00 27.68 O ATOM 1539 N THR B 331 69.442 −41.885 −57.707 1.00 28.07 N ATOM 1540 CA THR B 331 68.285 −42.473 −57.031 1.00 28.91 C ATOM 1541 CB THR B 331 67.175 −41.424 −56.829 1.00 26.85 C ATOM 1542 OG1 THR B 331 66.976 −40.698 −58.052 1.00 29.33 O ATOM 1543 CG2 THR B 331 67.513 −40.467 −55.698 1.00 30.16 C ATOM 1544 C THR B 331 67.674 −43.616 −57.826 1.00 27.23 C ATOM 1545 O THR B 331 67.367 −43.458 −59.015 1.00 22.40 O ATOM 1546 N GLU B 332 67.456 −44.755 −57.167 1.00 26.47 N ATOM 1547 CA GLU B 332 66.530 −45.756 −57.697 1.00 22.73 C ATOM 1548 CB GLU B 332 66.698 −47.100 −56.970 1.00 29.49 C ATOM 1549 CG GLU B 332 66.030 −48.267 −57.684 1.00 24.21 C ATOM 1550 CD GLU B 332 66.017 −49.520 −56.846 1.00 29.84 C ATOM 1551 OE1 GLU B 332 66.925 −50.362 −57.021 1.00 30.98 O ATOM 1552 OE2 GLU B 332 65.116 −49.656 −56.001 1.00 28.42 O ATOM 1553 C GLU a 332 65.105 −45.236 −57.521 1.00 22.22 C ATOM 1554 O GLU B 332 64.710 −44.827 −56.424 1.00 19.31 O ATOM 1555 N ILE B 333 64.340 −45.240 −58.610 1.00 22.08 N ATOM 1556 CA ILE B 333 62.947 −44.770 −58.570 1.00 19.15 C ATOM 1557 CB ILE B 333 62.649 −43.847 −59.787 1.00 22.55 C ATOM 1558 CG1 ILE B 333 63.606 −42.651 −59.779 1.00 23.08 C ATOM 1559 CD1 ILE B 333 63.485 −41.765 −58.537 1.00 21.33 C ATOM 1560 CG2 ILE B 333 61.201 −43.355 −59.763 1.00 21.98 C ATOM 1561 C ILE B 333 61.941 −45.952 −58.526 1.00 18.07 C ATOM 1562 O ILE B 333 60.940 −45.879 −57.822 1.00 17.92 O ATOM 1563 N THR B 334 62.209 −46.997 −59.303 1.00 18.22 N ATOM 1564 CA THR B 334 61.469 −48.281 −59.200 1.00 24.81 C ATOM 1565 CB THR B 334 60.305 −48.442 −60.216 1.00 30.63 C ATOM 1566 OG1 THR B 334 60.203 −47.329 −61.108 1.00 38.29 O ATOM 1567 CG2 THR B 334 59.032 −48.780 −59.544 1.00 18.71 C ATOM 1568 C THR B 334 62.333 −49.419 −59.601 1.00 21.83 C ATOM 1569 O THR B 334 63.541 −49.266 −59.839 1.00 24.25 O ATOM 1570 N THR B 335 61.676 −50.568 −59.776 1.00 19.42 N ATOM 1571 CA THR B 335 62.307 −51.751 −60.309 1.00 23.17 C ATOM 1572 CB THR B 335 62.603 −52.772 −59.205 1.00 26.92 C ATOM 1573 OG1 THR B 335 61.383 −53.416 −58.816 1.00 24.69 O ATOM 1574 CG2 THR B 335 63.266 −52.084 −57.954 1.00 23.55 C ATOM 1575 C THR B 335 61.360 −52.400 −61.305 1.00 22.11 C ATOM 1576 O THR B 335 60.134 −52.212 −61.232 1.00 22.40 O ATOM 1577 N LYS B 336 61.910 −53.203 −62.196 1.00 24.64 N ATOM 1578 CA LYS B 336 61.093 −53.912 −63.173 1.00 30.13 C ATOM 1579 CB LYS B 336 61.959 −54.729 −64.126 1.00 30.69 C ATOM 1580 CG LYS B 336 62.911 −53.903 −64.979 1.00 36.55 C ATOM 1581 CD LYS B 336 63.489 −54.756 −66.098 1.00 38.79 C ATOM 1582 CE LYS B 336 64.540 −54.007 −66.908 1.00 50.00 C ATOM 1583 NZ LYS B 336 65.172 −54.919 −67.907 1.00 48.46 N ATOM 1584 C LYS B 336 60.065 −54.827 −62.502 1.00 27.48 C ATOM 1585 O LYS B 336 59.062 −55.161 −63.110 1.00 22.14 O ATOM 1586 N ASN B 337 60.314 −55.221 −61.243 1.00 25.94 N ATOM 1587 CA ASN B 337 59.374 −56.092 −60.521 1.00 24.82 C ATOM 1588 CB ASN B 337 59.987 −56.581 −59.200 1.00 21.33 C ATOM 1589 CG ASN B 337 61.192 −57.472 −59.419 1.00 33.06 C ATOM 1590 OD1 ASN B 337 62.280 −57.204 −58.920 1.00 36.10 O ATOM 1591 ND2 ASN B 337 61.014 −58.492 −60.204 1.00 31.21 N ATOM 1592 C ASN B 337 58.045 −55.416 −60.241 1.00 23.32 C ATOM 1593 O ASN B 337 57.024 −56.083 −60.045 1.00 24.76 O ATOM 1594 N GLU B 338 58.055 −54.091 −60.202 1.00 20.06 N ATOM 1595 CA GLU B 338 56.863 −53.335 −59.859 1.00 19.51 C ATOM 1596 CB GLU B 338 57.234 −52.044 −59.096 1.00 22.47 C ATOM 1597 CG GLU B 338 57.997 −52.294 −57.797 1.00 23.74 C ATOM 1598 CD GLU B 338 57.300 −53.302 −56.897 1.00 30.38 C ATOM 1599 OE1 GLU B 338 56.066 −53.214 −56.710 1.00 26.60 O ATOM 1600 OE2 GLU B 338 57.987 −54.174 −56.359 1.00 40.84 O ATOM 1601 C GLU B 338 55.973 −52.987 −61.067 1.00 18.40 C ATOM 1602 O GLU B 338 54.909 −52.417 −60.902 1.00 17.39 O ATOM 1603 N ILE B 339 56.440 −53.294 −62.271 1.00 20.06 N ATOM 1604 CA ILE B 339 55.715 −52.907 −63.480 1.00 18.96 C ATOM 1605 CB ILE B 339 56.563 −53.177 −64.737 1.00 22.28 C ATOM 1606 CG1 ILE B 339 57.792 −52.254 −64.759 1.00 18.17 C ATOM 1607 CD1 ILE B 339 58.772 −52.593 −65.892 1.00 25.04 C ATOM 1608 CG2 ILE B 339 55.713 −53.006 −66.010 1.00 24.94 C ATOM 1609 C ILE B 339 54.387 −53.675 −63.609 1.00 20.85 C ATOM 1610 O ILE B 339 54.338 −54.876 −63.384 1.00 23.21 O ATOM 1611 N PHE B 340 53.318 −52.961 −63.927 1.00 18.09 N ATOM 1612 CA PHE B 340 52.050 −53.613 −64.293 1.00 19.52 C ATOM 1613 CB PHE B 340 51.119 −53.750 −63.043 1.00 20.09 C ATOM 1614 CG PHE B 340 50.470 −52.463 −62.622 1.00 19.49 C ATOM 1615 CD2 PHE B 340 49.106 −52.250 −62.857 1.00 16.21 C ATOM 1616 CE2 PHE B 340 48.497 −51.056 −62.510 1.00 16.48 C ATOM 1617 CZ PHE B 340 49.235 −50.030 −61.934 1.00 20.44 C ATOM 1618 CE1 PHE B 340 50.610 −50.210 −61.710 1.00 21.71 C ATOM 1619 CD1 PHE B 340 51.221 −51.422 −62.055 1.00 18.66 C ATOM 1620 C PHE B 340 51.400 −52.826 −65.405 1.00 24.86 C ATOM 1621 O PHE B 340 51.911 −51.767 −65.816 1.00 21.71 O ATOM 1622 N SER B 341 50.286 −53.330 −65.922 1.00 25.72 N ATOM 1623 CA SER B 341 49.679 −52.695 −67.078 1.00 26.83 C ATOM 1624 CB SER B 341 49.925 −53.519 −68.341 1.00 30.87 C ATOM 1625 OG SER B 341 49.374 −52.858 −69.475 1.00 31.98 O ATOM 1626 C SER B 341 48.201 −52.449 −66.884 1.00 25.33 C ATOM 1627 O SER B 341 47.450 −53.356 −66.524 1.00 29.73 O ATOM 1628 N LEU B 342 47.800 −51.207 −67.084 1.00 23.60 N ATOM 1629 CA LEU B 342 46.399 −50.827 −67.091 1.00 26.62 C ATOM 1630 CB LEU B 342 46.249 −49.467 −66.434 1.00 30.73 C ATOM 1631 CG LEU B 342 45.538 −49.332 −65.096 1.00 32.89 C ATOM 1632 CD1 LEU B 342 45.436 −50.642 −64.319 1.00 33.84 C ATOM 1633 CD2 LEU B 342 46.164 −48.221 −64.268 1.00 37.00 C ATOM 1634 C LEU B 342 45.784 −50.795 −68.531 1.00 32.15 C ATOM 1635 O LEU B 342 44.602 −50.535 −68.697 1.00 31.92 O ATOM 1636 N SER B 343 46.599 −51.033 −69.545 1.00 29.79 N ATOM 1637 CA SER B 343 46.090 −51.055 −70.920 1.00 34.22 C ATOM 1638 CB SER B 343 47.208 −50.772 −71.907 1.00 33.17 C ATOM 1639 OG SER B 343 48.152 −51.817 −71.903 1.00 42.82 O ATOM 1640 C SER B 343 45.380 −52.383 −71.248 1.00 35.37 C ATOM 1641 O SER B 343 45.751 −53.456 −70.746 1.00 24.05 O ATOM 1642 N LEU B 344 44.339 −52.304 −72.061 1.00 35.22 N ATOM 1643 CA LEU B 344 43.537 −53.502 −72.362 1.00 34.17 C ATOM 1644 CB LEU B 344 42.087 −53.119 −72.684 1.00 34.64 C ATOM 1645 CG LEU B 344 41.375 −52.330 −71.565 1.00 36.65 C ATOM 1646 CD1 LEU B 344 39.920 −52.044 −71.908 1.00 35.55 C ATOM 1647 CD2 LEU B 344 41.486 −53.023 −70.196 1.00 34.02 C ATOM 1648 C LEU B 344 44.187 −54.321 −73.472 1.00 38.45 C ATOM 1649 O LEU B 344 44.837 −53.761 −74.374 1.00 39.44 O ATOM 1650 N CYS B 345 44.065 −55.645 −73.375 1.00 36.57 N ATOM 1651 CA CYS B 345 44.767 −56.569 −74.285 1.00 42.35 C ATOM 1652 CB CYS B 345 45.367 −57.760 −73.510 1.00 41.87 C ATOM 1653 SG CYS B 345 46.163 −57.352 −71.914 1.00 51.52 S ATOM 1654 C CYS B 345 43.890 −57.067 −75.461 1.00 49.69 C ATOM 1655 O CYS B 345 44.379 −57.775 −76.348 1.00 53.67 O ATOM 1656 N GLY B 346 42.610 −56.681 −75.467 1.00 48.13 N ATOM 1657 CA GLY B 346 41.664 −57.096 −76.528 1.00 47.69 C ATOM 1658 C GLY B 346 41.101 −55.939 −77.370 1.00 48.54 C ATOM 1659 O GLY B 346 41.584 −54.798 −77.279 1.00 44.60 O ATOM 1660 N PRO B 347 40.047 −56.219 −78.180 1.00 49.78 N ATOM 1661 CA PRO B 347 39.484 −55.230 −79.123 1.00 44.60 C ATOM 1662 CB PRO B 347 38.247 −55.951 −79.702 1.00 45.79 C ATOM 1663 CG PRO B 347 38.509 −57.398 −79.487 1.00 44.52 C ATOM 1664 CD PRO B 347 39.294 −57.485 −78.203 1.00 43.09 C ATOM 1665 C PRO B 347 39.061 −53.907 −78.458 1.00 49.17 C ATOM 1666 O PRO B 347 39.048 −52.866 −79.119 1.00 48.51 O ATOM 1667 N MET B 348 38.725 −53.953 −77.167 1.00 42.16 N ATOM 1668 CA MET B 348 38.362 −52.744 −76.414 1.00 55.36 C ATOM 1669 CB MET B 348 37.900 −53.105 −75.000 1.00 47.21 C ATOM 1670 CG MET B 348 36.677 −54.003 −74.953 1.00 63.11 C ATOM 1671 SD MET B 348 35.389 −53.356 −73.877 1.00 82.63 S ATOM 1672 CE MET B 348 34.473 −52.336 −75.041 1.00 75.27 C ATOM 1673 C MET B 348 39.500 −51.704 −76.348 1.00 48.70 C ATOM 1674 O MET B 348 40.674 −52.034 −76.545 1.00 47.54 O ATOM 1675 N GLY B 356 48.931 −42.541 −79.352 1.00 63.03 N ATOM 1676 CA GLY B 356 50.309 −42.762 −79.779 1.00 71.69 C ATOM 1677 C GLY B 356 51.305 −42.690 −78.635 1.00 75.51 C ATOM 1678 O GLY B 356 52.508 −42.502 −78.852 1.00 71.05 O ATOM 1679 N TYR B 357 50.797 −42.823 −77.411 1.00 70.15 N ATOM 1680 CA TYR B 357 51.641 −42.961 −76.221 1.00 64.86 C ATOM 1681 CB TYR B 357 51.143 −42.034 −75.102 1.00 53.46 C ATOM 1682 CG TYR B 357 51.532 −40.584 −75.329 1.00 40.26 C ATOM 1683 CD1 TYR B 357 52.782 −40.116 −74.936 1.00 41.69 C ATOM 1684 CE1 TYR B 357 53.162 −38.796 −75.155 1.00 44.87 C ATOM 1685 CZ TYR B 357 52.277 −37.918 −75.789 1.00 36.22 C ATOM 1686 OH TYR B 357 52.668 −36.620 −76.005 1.00 35.67 O ATOM 1687 CE2 TYR B 357 51.030 −38.360 −76.204 1.00 37.32 C ATOM 1688 CD2 TYR B 357 50.667 −39.693 −75.990 1.00 34.35 C ATOM 1689 C TYR B 357 51.702 −44.435 −75.786 1.00 80.45 C ATOM 1690 O TYR B 357 51.891 −44.764 −74.595 1.00 53.74 O ATOM 1691 N VAL B 358 51.566 −45.303 −76.795 1.00 89.75 N ATOM 1692 CA VAL B 358 51.647 −46.763 −76.676 1.00 81.56 C ATOM 1693 CB VAL B 358 52.154 −47.397 −78.007 1.00 81.45 C ATOM 1694 CG2 VAL B 358 51.595 −46.635 −79.220 1.00 52.77 C ATOM 1695 CG1 VAL B 358 51.794 −48.879 −78.073 1.00 74.26 C ATOM 1696 C VAL B 358 52.491 −47.253 −75.484 1.00 82.83 C ATOM 1697 O VAL B 358 52.010 −48.040 −74.665 1.00 72.88 O ATOM 1698 N HIS B 359 53.736 −46.774 −75.385 1.00 80.53 N ATOM 1699 CA HIS B 359 54.603 −47.100 −74.245 1.00 67.40 C ATOM 1700 CB HIS B 359 55.380 −48.396 −74.498 1.00 74.36 C ATOM 1701 CG HIS B 359 55.713 −48.639 −75.957 1.00 109.23 C ATOM 1702 ND1 HIS B 359 56.345 −47.723 −76.723 1.00 111.85 N ATOM 1703 CE1 HIS B 359 56.503 −48.213 −77.967 1.00 114.31 C ATOM 1704 NE2 HIS B 359 55.979 −49.449 −77.999 1.00 115.36 N ATOM 1705 CD2 HIS B 359 55.484 −49.746 −76.778 1.00 108.09 C ATOM 1706 C HIS B 359 55.543 −45.978 −73.875 1.00 66.12 C ATOM 1707 O HIS B 359 56.745 −46.183 −73.749 1.00 81.42 O ATOM 1708 N GLU B 360 54.997 −44.781 −73.687 1.00 66.19 N ATOM 1709 CA GLU B 360 55.780 −43.634 −73.198 1.00 60.10 C ATOM 1710 CB GLU B 360 55.187 −42.339 −73.731 1.00 59.59 C ATOM 1711 CG GLU B 360 56.219 −41.334 −74.221 1.00 69.87 C ATOM 1712 CD GLU B 360 56.584 −41.543 −75.681 1.00 80.44 C ATOM 1713 OE1 GLU B 360 57.798 −41.568 −75.989 1.00 89.35 O ATOM 1714 OE2 GLU B 360 55.657 −41.683 −76.523 1.00 69.85 O ATOM 1715 C GLU B 360 55.780 −43.599 −71.659 1.00 59.46 C ATOM 1716 O GLU B 360 56.629 −42.909 −71.015 1.00 33.01 O ATOM 1717 N THR B 361 54.816 −44.323 −71.080 1.00 46.42 N ATOM 1718 CA THR B 361 54.509 −44.230 −69.653 1.00 49.04 C ATOM 1719 CB THR B 361 53.128 −43.564 −69.392 1.00 52.32 C ATOM 1720 OG1 THR B 361 53.110 −42.257 −69.976 1.00 75.08 O ATOM 1721 CG2 THR B 361 52.840 −43.434 −67.880 1.00 43.73 C ATOM 1722 C THR B 361 54.550 −45.616 −69.048 1.00 40.27 C ATOM 1723 O THR B 361 53.838 −46.515 −69.469 1.00 33.11 O ATOM 1724 N LEU B 362 55.470 −45.797 −68.122 1.00 35.08 N ATOM 1725 CA LEU B 362 55.558 −46.998 −67.380 1.00 30.03 C ATOM 1726 CB LEU B 362 56.991 −47.162 −66.876 1.00 27.65 C ATOM 1727 CG LEU B 362 57.352 −48.572 −66.491 1.00 33.81 C ATOM 1728 CD1 LEU B 362 57.477 −49.446 −67.730 1.00 38.59 C ATOM 1729 CD2 LEU B 362 58.655 −48.559 −65.709 1.00 47.77 C ATOM 1730 C LEU B 362 54.618 −46.830 −66.198 1.00 29.49 C ATOM 1731 O LEU B 362 54.650 −45.806 −65.545 1.00 28.13 O ATOM 1732 N THR B 363 53.752 −47.804 −65.937 1.00 23.26 N ATOM 1733 CA THR B 363 52.994 −47.762 −64.687 1.00 20.27 C ATOM 1734 CB THR B 363 51.465 −47.984 −64.900 1.00 21.87 C ATOM 1735 OG1 THR B 363 51.278 −49.143 −65.699 1.00 25.84 O ATOM 1736 CG2 THR B 363 50.845 −46.800 −65.628 1.00 25.43 C ATOM 1737 C THR B 363 53.561 −48.818 −63.719 1.00 17.27 C ATOM 1738 O THR B 363 53.835 −49.966 −64.114 1.00 21.02 O ATOM 1739 N VAL B 364 53.763 −48.409 −62.472 1.00 18.20 N ATOM 1740 CA VAL B 364 54.317 −49.306 −61.443 1.00 16.03 C ATOM 1741 CB VAL B 364 55.846 −49.060 −61.164 1.00 17.93 C ATOM 1742 CG1 VAL B 364 56.685 −49.372 −62.410 1.00 17.30 C ATOM 1743 CG2 VAL B 364 56.115 −47.640 −60.635 1.00 16.12 C ATOM 1744 C VAL B 364 53.520 −49.197 −60.158 1.00 13.99 C ATOM 1745 O VAL B 364 52.955 −48.135 −59.853 1.00 14.95 O ATOM 1746 N TYR B 365 53.497 −50.299 −59.379 1.00 15.27 N ATOM 1747 CA TYR B 365 52.726 −50.335 −58.132 1.00 15.27 C ATOM 1748 CB TYR B 365 52.594 −51.798 −57.635 1.00 15.22 C ATOM 1749 CG TYR B 365 51.527 −52.602 −58.396 1.00 16.64 C ATOM 1750 CD1 TYR B 365 50.210 −52.176 −58.427 1.00 16.82 C ATOM 1751 CE1 TYR B 365 49.215 −52.930 −59.094 1.00 18.58 C ATOM 1752 CZ TYR B 365 49.568 −54.092 −59.732 1.00 20.21 C ATOM 1753 OH TYR B 365 48.596 −54.847 −60.364 1.00 22.48 O ATOM 1754 CE2 TYR B 365 50.870 −54.547 −59.692 1.00 18.91 C ATOM 1755 CD2 TYR B 365 51.844 −53.798 −59.024 1.00 17.45 C ATOM 1756 C TYR B 365 53.367 −49.479 −57.048 1.00 14.92 C ATOM 1757 O TYR B 365 52.683 −48.951 −56.154 1.00 16.09 O ATOM 1758 N LYS B 366 54.684 −49.431 −57.099 1.00 16.31 N ATOM 1759 CA LYS B 366 55.491 −48.888 −56.041 1.00 16.02 C ATOM 1760 CB LYS B 366 56.013 −50.034 −55.148 1.00 16.03 C ATOM 1761 CG LYS B 366 54.941 −50.708 −54.293 1.00 15.69 C ATOM 1762 CD LYS B 366 54.623 −49.785 −53.126 1.00 19.34 C ATOM 1763 CE LYS B 366 53.671 −50.394 −52.140 1.00 29.43 C ATOM 1764 NZ LYS B 366 53.463 −49.421 −51.012 1.00 25.44 N ATOM 1765 C LYS B 366 56.679 −48.138 −56.638 1.00 15.70 C ATOM 1766 O LYS B 366 57.276 −48.593 −57.622 1.00 17.11 O ATOM 1767 N ALA B 367 57.056 −47.041 −55.968 1.00 17.02 N ATOM 1768 CA ALA B 367 58.229 −46.234 −56.353 1.00 19.37 C ATOM 1769 CB ALA B 367 57.825 −45.121 −57.313 1.00 18.65 C ATOM 1770 C ALA B 367 58.857 −45.638 −55.119 1.00 18.92 C ATOM 1771 O ALA B 367 58.261 −45.644 −54.007 1.00 19.36 O ATOM 1772 N SER B 368 60.053 −45.087 −55.304 1.00 19.37 N ATOM 1773 CA SER B 368 60.830 −44.567 −54.199 1.00 18.94 C ATOM 1774 CB SER B 368 61.826 −45.640 −53.736 1.00 18.13 C ATOM 1775 OG SER B 368 62.722 −45.985 −54.789 1.00 23.37 O ATOM 1776 C SER B 368 61.582 −43.292 −54.615 1.00 18.59 C ATOM 1777 O SER B 368 61.783 −43.020 −55.833 1.00 19.06 O ATOM 1778 N ASN B 369 61.989 −42.511 −53.614 1.00 20.63 N ATOM 1779 CA ASN B 369 62.876 −41.382 −53.839 1.00 20.71 C ATOM 1780 CB ASN B 369 64.166 −41.843 −54.529 1.00 19.23 C ATOM 1781 CG ASN B 369 65.078 −42.643 −53.602 1.00 29.83 C ATOM 1782 OD1 ASN B 369 65.663 −43.660 −53.995 1.00 34.23 O ATOM 1783 ND2 ASN B 369 65.182 −42.204 −52.379 1.00 23.95 N ATOM 1784 C ASN B 369 62.205 −40.277 −54.670 1.00 25.05 C ATOM 1785 O ASN B 369 62.885 −39.464 −55.286 1.00 28.63 O ATOM 1786 N LEU B 370 60.874 −40.249 −54.663 1.00 26.36 N ATOM 1787 CA LEU B 370 60.132 −39.181 −55.312 1.00 24.68 C ATOM 1788 CB LEU B 370 59.050 −39.757 −56.237 1.00 24.27 C ATOM 1789 CG LEU B 370 59.539 −40.516 −57.460 1.00 19.62 C ATOM 1790 CD1 LEU B 370 58.316 −41.163 −58.129 1.00 23.24 C ATOM 1791 CD2 LEU B 370 60.243 −39.576 −58.442 1.00 21.56 C ATOM 1792 C LEU B 370 59.476 −38.284 −54.283 1.00 26.74 C ATOM 1793 O LEU B 370 58.915 −38.756 −53.297 1.00 26.36 O ATOM 1794 N ASN B 371 59.542 −36.982 −54.526 1.00 26.56 N ATOM 1795 CA ASN B 371 58.792 −36.013 −53.767 1.00 24.89 C ATOM 1796 CB ASN B 371 59.643 −34.761 −53.507 1.00 33.82 C ATOM 1797 CG ASN B 371 60.528 −34.896 −52.277 1.00 43.42 C ATOM 1798 OD1 ASN B 371 60.119 −35.457 −51.257 1.00 49.45 O ATOM 1799 ND2 ASN B 371 61.746 −34.377 −52.368 1.00 38.40 N ATOM 1800 C ASN B 371 57.545 −35.608 −54.531 1.00 24.46 C ATOM 1801 O ASN B 371 57.600 −35.365 −55.744 1.00 21.96 O ATOM 1802 N LEU B 372 56.431 −35.505 −53.810 1.00 24.82 N ATOM 1803 CA LEU B 372 55.156 −35.104 −54.408 1.00 25.02 C ATOM 1804 CB LEU B 372 53.994 −35.765 −53.673 1.00 25.54 C ATOM 1805 CG LEU B 372 53.983 −37.287 −53.670 1.00 29.40 C ATOM 1806 CD1 LEU B 372 52.802 −37.773 −52.838 1.00 32.39 C ATOM 1807 CD2 LEU B 372 53.926 −37.839 −55.092 1.00 27.68 C ATOM 1808 C LEU B 372 55.007 −33.601 −54.323 1.00 31.80 C ATOM 1809 O LEU B 372 55.315 −33.004 −53.283 1.00 27.90 O ATOM 1810 N ILE B 373 54.501 −33.000 −55.403 1.00 29.23 N ATOM 1811 CA ILE B 373 54.336 −31.542 −55.515 1.00 34.49 C ATOM 1812 CB ILE B 373 54.970 −30.999 −56.844 1.00 36.77 C ATOM 1813 CG1 ILE B 373 56.355 −31.586 −57.080 1.00 34.94 C ATOM 1814 CD1 ILE B 373 57.371 −31.204 −56.035 1.00 42.02 C ATOM 1815 CG2 ILE B 373 55.024 −29.475 −56.836 1.00 42.71 C ATOM 1816 C ILE B 373 52.854 −31.215 −55.552 1.00 35.04 C ATOM 1817 O ILE B 373 52.129 −31.735 −56.393 1.00 33.44 O ATOM 1818 N GLY B 374 52.397 −30.355 −54.646 1.00 35.66 N ATOM 1819 CA GLY B 374 51.001 −29.918 −54.669 1.00 38.32 C ATOM 1820 C GLY B 374 50.012 −31.004 −54.252 1.00 45.77 C ATOM 1821 O GLY B 374 50.302 −31.833 −53.365 1.00 38.22 O ATOM 1822 N ARG B 375 48.854 −31.010 −54.906 1.00 36.94 N ATOM 1823 CA ARG B 375 47.719 −31.820 −54.483 1.00 42.99 C ATOM 1824 CB ARG B 375 46.681 −30.933 −53.782 1.00 49.49 C ATOM 1825 CG ARG B 375 47.138 −30.354 −52.442 1.00 63.58 C ATOM 1826 CD ARG B 375 46.374 −29.083 −52.077 1.00 75.38 C ATOM 1827 NE ARG B 375 44.920 −29.268 −52.133 1.00 86.36 N ATOM 1828 CZ ARG B 375 44.138 −28.820 −53.116 1.00 83.29 C ATOM 1829 NH1 ARG B 375 44.657 −28.143 −54.137 1.00 84.63 N ATOM 1830 NH2 ARG B 375 42.832 −29.049 −53.078 1.00 81.05 N ATOM 1831 C ARG B 375 47.082 −32.482 −55.689 1.00 31.24 C ATOM 1832 O ARG B 375 47.186 −31.964 −56.794 1.00 37.99 O ATOM 1833 N PRO B 376 46.357 −33.594 −55.478 1.00 31.59 N ATOM 1834 CA PRO B 376 45.809 −34.325 −56.613 1.00 29.94 C ATOM 1835 CB PRO B 376 45.043 −35.467 −55.942 1.00 32.72 C ATOM 1836 CG PRO B 376 45.799 −35.722 −54.681 1.00 26.98 C ATOM 1837 CD PRO B 376 46.174 −34.342 −54.213 1.00 31.89 C ATOM 1838 C PRO B 376 44.858 −33.508 −57.474 1.00 32.16 C ATOM 1839 O PRO B 376 44.032 −32.763 −56.955 1.00 32.07 O ATOM 1840 N SER B 377 44.930 −33.719 −58.781 1.00 27.14 N ATOM 1841 CA SER B 377 43.961 −33.142 −59.716 1.00 25.64 C ATOM 1842 CB SER B 377 44.646 −32.000 −60.504 1.00 29.29 C ATOM 1843 OG SER B 377 43.916 −31.657 −61.655 1.00 26.64 O ATOM 1844 C SER B 377 43.468 −34.214 −60.676 1.00 23.23 C ATOM 1845 O SER B 377 44.216 −35.103 −61.035 1.00 28.92 O ATOM 1846 N THR B 378 42.209 −34.123 −61.105 1.00 22.77 N ATOM 1847 CA THR B 378 41.674 −35.013 −62.148 1.00 23.90 C ATOM 1848 CB THR B 378 40.229 −35.459 −61.849 1.00 31.81 C ATOM 1849 OG1 THR B 378 39.424 −34.305 −61.638 1.00 30.11 O ATOM 1850 CG2 THR B 378 40.173 −36.349 −60.614 1.00 26.71 C ATOM 1851 C THR B 378 41.674 −34.360 −63.541 1.00 23.70 C ATOM 1852 O THR B 378 41.319 −34.994 −64.540 1.00 22.07 O ATOM 1853 N VAL B 379 42.139 −33.125 −63.615 1.00 25.93 N ATOM 1854 CA VAL B 379 42.142 −32.395 −64.889 1.00 25.41 C ATOM 1855 CB VAL B 379 42.594 −30.926 −64.673 1.00 28.55 C ATOM 1856 CG1 VAL B 379 42.661 −30.181 −66.001 1.00 35.39 C ATOM 1857 CG2 VAL B 379 41.656 −30.206 −63.688 1.00 30.31 C ATOM 1858 C VAL B 379 43.037 −33.105 −65.925 1.00 23.26 C ATOM 1859 O VAL B 379 44.223 −33.386 −65.653 1.00 25.38 O ATOM 1860 N HIS B 380 42.459 −33.447 −67.077 1.00 20.20 N ATOM 1861 CA HIS B 380 43.187 −34.132 −68.185 1.00 25.05 C ATOM 1862 CB HIS B 380 44.353 −33.274 −68.713 1.00 23.09 C ATOM 1863 CG HIS B 380 43.963 −31.857 −69.099 1.00 26.55 C ATOM 1864 ND1 HIS B 380 42.912 −31.581 −69.898 1.00 29.63 N ATOM 1865 CE1 HIS B 380 42.822 −30.238 −70.078 1.00 24.85 C ATOM 1866 NE2 HIS B 380 43.827 −29.661 −69.398 1.00 25.66 N ATOM 1867 CD2 HIS B 380 44.555 −30.627 −68.788 1.00 25.94 C ATOM 1868 C HIS B 380 43.740 −35.499 −67.807 1.00 23.87 C ATOM 1869 O HIS B 380 44.638 −36.004 −68.471 1.00 19.89 O ATOM 1870 N SER B 381 43.215 −36.119 −66.759 1.00 27.13 N ATOM 1871 CA SER B 381 43.830 −37.365 −66.285 1.00 21.54 C ATOM 1872 CB SER B 381 43.131 −37.898 −65.036 1.00 26.12 C ATOM 1873 OG SER B 381 43.723 −39.137 −64.656 1.00 27.41 O ATOM 1874 C SER B 381 43.914 −38.451 −67.361 1.00 19.95 C ATOM 1875 O SER B 381 42.920 −38.801 −68.014 1.00 25.35 O ATOM 1876 N TRP B 382 45.099 −39.001 −67.528 1.00 17.98 N ATOM 1877 CA TRP B 382 45.320 −40.052 −68.483 1.00 20.29 C ATOM 1878 CB TRP B 382 46.806 −40.220 −68.752 1.00 21.35 C ATOM 1879 CG TRP B 382 47.434 −38.964 −69.246 1.00 24.47 C ATOM 1880 CD1 TRP B 382 46.842 −37.986 −70.057 1.00 21.06 C ATOM 1881 NE1 TRP B 382 47.738 −36.984 −70.328 1.00 23.04 N ATOM 1882 CE2 TRP B 382 48.929 −37.237 −69.716 1.00 24.13 C ATOM 1883 CD2 TRP B 382 48.794 −38.510 −69.017 1.00 24.12 C ATOM 1884 CE3 TRP B 382 49.892 −39.016 −68.312 1.00 26.14 C ATOM 1885 CZ3 TRP B 382 51.083 −38.277 −68.314 1.00 26.99 C ATOM 1886 CH2 TRP B 382 51.188 −37.051 −68.991 1.00 31.26 C ATOM 1887 CZ2 TRP B 382 50.114 −36.506 −69.701 1.00 26.83 C ATOM 1888 C TRP B 382 44.731 −41.376 −68.079 1.00 22.92 C ATOM 1889 O TRP B 382 44.714 −42.309 −68.875 1.00 25.45 O ATOM 1890 N PHE B 383 44.283 −41.478 −66.832 1.00 22.28 N ATOM 1891 CA PHE B 383 43.734 −42.745 −66.318 1.00 24.17 C ATOM 1892 CB PHE B 383 44.723 −43.411 −65.335 1.00 20.51 C ATOM 1893 CG PHE B 383 46.015 −43.807 −65.959 1.00 20.63 C ATOM 1894 CD1 PHE B 383 46.103 −44.959 −66.733 1.00 20.80 C ATOM 1895 CE1 PHE B 383 47.303 −45.330 −67.333 1.00 25.81 C ATOM 1896 CZ PHE B 383 48.425 −44.535 −67.185 1.00 26.22 C ATOM 1897 CE2 PHE B 383 48.339 −43.351 −66.445 1.00 23.89 C ATOM 1898 CD2 PHE B 383 47.141 −42.989 −65.841 1.00 20.32 C ATOM 1899 C PHE B 383 42.425 −42.425 −65.642 1.00 25.14 C ATOM 1900 O PHE B 383 42.399 −41.993 −64.476 1.00 23.05 O ATOM 1901 N PRO B 384 41.322 −42.514 −66.405 1.00 25.62 N ATOM 1902 CA PRO B 384 40.034 −42.087 −65.872 1.00 29.68 C ATOM 1903 CB PRO B 384 39.066 −42.447 −66.999 1.00 39.89 C ATOM 1904 CG PRO B 384 39.894 −42.273 −68.235 1.00 39.35 C ATOM 1905 CD PRO B 384 41.259 −42.788 −67.854 1.00 32.11 C ATOM 1906 C PRO B 384 39.698 −42.835 −64.591 1.00 27.51 C ATOM 1907 O PRO B 384 39.950 −44.033 −64.493 1.00 30.82 O ATOM 1908 N GLY B 385 39.226 −42.106 −63.594 1.00 23.60 N ATOM 1909 CA GLY B 385 39.005 −42.658 −62.280 1.00 28.07 C ATOM 1910 C GLY B 385 40.113 −42.318 −61.303 1.00 31.07 C ATOM 1911 O GLY B 385 39.958 −42.517 −60.097 1.00 30.97 O ATOM 1912 N TYR B 386 41.231 −41.794 −61.821 1.00 25.77 N ATOM 1913 CA TYR B 386 42.369 −41.389 −60.980 1.00 23.05 C ATOM 1914 CB TYR B 386 43.619 −42.171 −61.365 1.00 21.82 C ATOM 1915 CG TYR B 386 43.533 −43.670 −61.067 1.00 19.56 C ATOM 1916 CD2 TYR B 386 44.003 −44.193 −59.841 1.00 24.10 C ATOM 1917 CE2 TYR B 386 43.898 −45.566 −59.556 1.00 19.69 C ATOM 1918 CZ TYR B 386 43.384 −46.430 −60.539 1.00 22.41 C ATOM 1919 OH TYR B 386 43.320 −47.801 −60.318 1.00 19.99 O ATOM 1920 CE1 TYR B 386 42.930 −45.923 −61.759 1.00 22.45 C ATOM 1921 CD1 TYR B 386 43.020 −44.549 −62.010 1.00 21.07 C ATOM 1922 C TYR B 386 42.696 −39.902 −61.085 1.00 25.43 C ATOM 1923 O TYR B 386 42.521 −39.285 −62.136 1.00 22.35 O ATOM 1924 N ALA B 387 43.212 −39.363 −59.990 1.00 24.74 N ATOM 1925 CA ALA B 387 43.769 −38.046 −59.949 1.00 25.37 C ATOM 1926 CB ALA B 387 43.312 −37.339 −58.681 1.00 24.07 C ATOM 1927 C ALA B 387 45.284 −38.168 −59.979 1.00 26.78 C ATOM 1928 O ALA B 387 45.826 −39.205 −59.625 1.00 27.99 O ATOM 1929 N TRP B 388 45.974 −37.110 −60.403 1.00 22.43 N ATOM 1930 CA TRP B 388 47.441 −37.133 −60.485 1.00 19.83 C ATOM 1931 CB TRP B 388 47.902 −36.943 −61.937 1.00 21.42 C ATOM 1932 CG TRP B 388 47.366 −35.689 −62.576 1.00 23.56 C ATOM 1933 CD1 TRP B 388 46.229 −35.571 −63.382 1.00 23.07 C ATOM 1934 NE1 TRP B 388 46.045 −34.245 −63.773 1.00 24.16 N ATOM 1935 CE2 TRP B 388 47.003 −33.449 −63.247 1.00 25.32 C ATOM 1936 CD2 TRP B 388 47.909 −34.314 −62.471 1.00 23.01 C ATOM 1937 CE3 TRP B 388 48.993 −33.737 −61.818 1.00 22.08 C ATOM 1938 CZ3 TRP B 388 49.202 −32.338 −61.947 1.00 27.14 C ATOM 1939 CH2 TRP B 388 48.316 −31.528 −62.706 1.00 25.60 C ATOM 1940 CZ2 TRP B 388 47.219 −32.079 −63.380 1.00 24.52 C ATOM 1941 C TRP B 388 48.065 −36.083 −59.617 1.00 20.56 C ATOM 1942 O TRP B 388 47.480 −34.999 −59.396 1.00 24.79 O ATOM 1943 N THR B 389 49.256 −36.391 −59.110 1.00 23.53 N ATOM 1944 CA THR B 389 50.100 −35.439 −58.390 1.00 24.50 C ATOM 1945 CB THR B 389 50.169 −35.771 −56.878 1.00 26.86 C ATOM 1946 OG1 THR B 389 48.851 −35.822 −56.334 1.00 21.82 O ATOM 1947 CG2 THR B 389 50.993 −34.715 −56.133 1.00 26.94 C ATOM 1948 C THR B 389 51.518 −35.557 −58.946 1.00 23.47 C ATOM 1949 O THR B 389 52.059 −36.655 −59.037 1.00 21.83 O ATOM 1950 N ILE B 390 52.125 −34.419 −59.306 1.00 22.88 N ATOM 1951 CA ILE B 390 53.466 −34.409 −59.871 1.00 19.71 C ATOM 1952 CB ILE B 390 53.928 −32.967 −60.219 1.00 21.20 C ATOM 1953 CG1 ILE B 390 53.165 −32.442 −61.451 1.00 24.92 C ATOM 1954 CD1 ILE B 390 53.365 −30.953 −61.740 1.00 27.35 C ATOM 1955 CG2 ILE B 390 55.431 −32.939 −60.450 1.00 24.54 C ATOM 1956 C ILE B 390 54.491 −35.060 −58.917 1.00 20.69 C ATOM 1957 O ILE B 390 54.498 −34.787 −57.699 1.00 22.22 O ATOM 1958 N ALA B 391 55.342 −35.899 −59.479 1.00 18.66 N ATOM 1959 CA ALA B 391 56.384 −36.571 −58.704 1.00 22.41 C ATOM 1960 CB ALA B 391 56.117 −38.083 −58.648 1.00 19.22 C ATOM 1961 C ALA B 391 57.753 −36.281 −59.318 1.00 21.16 C ATOM 1962 O ALA B 391 57.992 −36.566 −60.494 1.00 24.34 O ATOM 1963 N GLN B 392 58.663 −35.745 −58.510 1.00 24.72 N ATOM 1964 CA GLN B 392 60.021 −35.468 −58.974 1.00 20.61 C ATOM 1965 CB GLN B 392 60.227 −33.946 −59.034 1.00 29.01 C ATOM 1966 CG GLN B 392 60.180 −33.277 −57.674 1.00 30.75 C ATOM 1967 CD GLN B 392 60.248 −31.760 −57.760 1.00 43.21 C ATOM 1968 OE1 GLN B 392 59.787 −31.155 −58.729 1.00 34.94 O ATOM 1969 NE2 GLN B 392 60.811 −31.142 −56.731 1.00 45.60 N ATOM 1970 C GLN B 392 61.113 −36.123 −58.099 1.00 23.41 C ATOM 1971 O GLN B 392 60.889 −36.393 −56.922 1.00 25.37 O ATOM 1972 N CYS B 393 62.281 −36.388 −58.695 1.00 23.20 N ATOM 1973 CA CYS B 393 63.419 −36.977 −57.981 1.00 24.77 C ATOM 1974 CB CYS B 393 64.638 −37.063 −58.922 1.00 22.66 C ATOM 1975 SG CYS B 393 66.185 −37.610 −58.175 1.00 25. 31 S ATOM 1976 C CYS B 393 63.754 −36.154 −56.732 1.00 27.61 C ATOM 1977 O CYS B 393 63.827 −34.925 −56.789 1.00 27.15 O ATOM 1978 N LYS B 394 63.911 −36.815 −55.595 1.00 19.95 N ATOM 1979 CA LYS B 394 64.166 −36.076 −54.371 1.00 23.60 C ATOM 1980 CB LYS B 394 63.973 −36.938 −53.137 1.00 26.08 C ATOM 1981 CG LYS B 394 65.127 −37.887 −52.857 1.00 25.52 C ATOM 1982 CD LYS B 394 64.981 −38.488 −51.474 1.00 35.48 C ATOM 1983 CE LYS B 394 66.248 −39.208 −51.071 1.00 39.32 C ATOM 1984 NZ LYS B 394 65.926 −40.438 −50.293 1.00 45.39 N ATOM 1985 C LYS B 394 65.558 −35.422 −54.355 1.00 28.58 C ATOM 1986 O LYS B 394 65.781 −34.496 −53.586 1.00 28.00 O ATOM 1987 N ILE B 395 66.466 −35.900 −55.211 1.00 25.13 N ATOM 1988 CA ILE B 395 67.850 −35.377 −55.276 1.00 32.87 C ATOM 1989 CB ILE B 395 68.898 −36.498 −55.606 1.00 29.09 C ATOM 1990 CG1 ILE B 395 69.046 −37.468 −54.430 1.00 25.99 C ATOM 1991 CD1 ILE B 395 69.050 −36.804 −53.057 1.00 31.34 C ATOM 1992 CG2 ILE B 395 70.266 −35.909 −55.988 1.00 33.04 C ATOM 1993 C ILE B 395 67.977 −34.179 −56.229 1.00 35.20 C ATOM 1994 O ILE B 395 68.404 −33.112 −55.817 1.00 37.26 O ATOM 1995 N CYS B 396 67.557 −34.345 −57.483 1.00 32.30 N ATOM 1996 CA CYS B 396 67.816 −33.336 −58.514 1.00 26.52 C ATOM 1997 CB CYS B 396 68.564 −33.963 −59.678 1.00 32.72 C ATOM 1998 SG CYS B 396 67.496 −34.951 −60.756 1.00 26.64 S ATOM 1999 C CYS B 396 66.562 −32.623 −59.017 1.00 34.67 C ATOM 2000 O CYS B 396 66.651 −31.716 −59.841 1.00 30.77 O ATOM 2001 N ALA B 397 65.394 −33.059 −58.533 1.00 30.00 N ATOM 2002 CA ALA B 397 64.099 −32.457 −58.864 1.00 25.27 C ATOM 2003 CB ALA B 397 64.056 −30.966 −58.510 1.00 28.66 C ATOM 2004 C ALA B 397 63.645 −32.691 −60.306 1.00 26.11 C ATOM 2005 O ALA B 397 62.715 −32.051 −60.766 1.00 27.15 O ATOM 2006 N SER B 398 64.295 −33.617 −61.007 1.00 25.27 N ATOM 2007 CA SER B 398 63.823 −34.015 −62.321 1.00 28.85 C ATOM 2008 CB SER B 398 64.699 −35.101 −62.890 1.00 28.47 C ATOM 2009 OG SER B 398 64.122 −35.645 −64.063 1.00 31.63 O ATOM 2010 C SER B 398 62.370 −34.497 −62.233 1.00 33.13 C ATOM 2011 O SER B 398 61.991 −35.214 −61.300 1.00 26.97 O ATOM 2012 N HIS B 399 61.556 −34.054 −63.174 1.00 26.79 N ATOM 2013 CA HIS B 399 60.158 −34.440 −63.227 1.00 29.56 C ATOM 2014 CB HIS B 399 59.371 −33.430 −64.067 1.00 31.35 C ATOM 2015 CG HIS B 399 58.965 −32.194 −63.302 1.00 43.04 C ATOM 2016 ND1 HIS B 399 59.667 −31.727 −62.243 1.00 51.35 N ATOM 2017 CE1 HIS B 399 59.066 −30.627 −61.757 1.00 41.17 C ATOM 2018 NE2 HIS B 399 57.987 −30.376 −62.508 1.00 52.23 N ATOM 2019 CD2 HIS B 399 57.890 −31.326 −63.469 1.00 47.63 C ATOM 2020 C HIS B 399 60.064 −35.809 −63.813 1.00 26.09 C ATOM 2021 O HIS B 399 60.208 −35.996 −65.009 1.00 26.83 O ATOM 2022 N ILE B 400 59.874 −36.803 −62.972 1.00 20.13 N ATOM 2023 CA ILE B 400 59.993 −38.173 −63.442 1.00 22.22 C ATOM 2024 CB ILE B 400 60.723 −39.048 −62.406 1.00 20.67 C ATOM 2025 CG1 ILE B 400 62.212 −38.660 −62.365 1.00 23.93 C ATOM 2026 CD1 ILE B 400 62.947 −39.221 −61.193 1.00 30.82 C ATOM 2027 CG2 ILE B 400 60.604 −40.526 −62.744 1.00 19.31 C ATOM 2028 C ILE B 400 58.628 −38.761 −63.804 1.00 19.11 C ATOM 2029 O ILE B 400 58.519 −39.591 −64.716 1.00 21.52 O ATOM 2030 N GLY B 401 57.603 −38.350 −63.087 1.00 22.40 N ATOM 2031 CA GLY B 401 56.221 −38.828 −63.402 1.00 25.38 C ATOM 2032 C GLY B 401 55.164 −38.245 −62.498 1.00 21.84 C ATOM 2033 O GLY B 401 55.206 −37.053 −62.160 1.00 21.94 O ATOM 2034 N TRP B 402 54.211 −39.106 −62.078 1.00 18.17 N ATOM 2035 CA TRP B 402 53.068 −38.705 −61.289 1.00 17.97 C ATOM 2036 CB TRP B 402 51.854 −38.359 −62.193 1.00 20.77 C ATOM 2037 CG TRP B 402 52.148 −37.254 −63.195 1.00 19.94 C ATOM 2038 CD1 TRP B 402 51.911 −35.901 −63.040 1.00 23.19 C ATOM 2039 NE1 TRP B 402 52.356 −35.182 −64.165 1.00 22.03 N ATOM 2040 CE2 TRP B 402 52.908 −36.023 −65.056 1.00 19.85 C ATOM 2041 CD2 TRP B 402 52.800 −37.388 −64.496 1.00 21.91 C ATOM 2042 CE3 TRP B 402 53.300 −38.468 −65.238 1.00 20.75 C ATOM 2043 CZ3 TRP B 402 53.923 −38.201 −66.471 1.00 26.36 C ATOM 2044 CH2 TRP B 402 54.002 −36.889 −66.993 1.00 23.65 C ATOM 2045 CZ2 TRP B 402 53.484 −35.776 −66.298 1.00 22.87 C ATOM 2046 C TRP B 402 52.637 −39.844 −60.402 1.00 19.19 C ATOM 2047 O TRP B 402 52.729 −41.013 −60.778 1.00 16.56 O ATOM 2048 N LYS B 403 52.109 −39.499 −59.251 1.00 17.80 N ATOM 2049 CA LYS B 403 51.378 −40.483 −58.447 1.00 22.47 C ATOM 2050 CB LYS B 403 51.545 −40.192 −56.978 1.00 19.11 C ATOM 2051 CG LYS B 403 51.000 −41.301 −56.057 1.00 24.56 C ATOM 2052 CD LYS B 403 50.951 −40.811 −54.608 1.00 29.24 C ATOM 2053 CE LYS B 403 50.879 −41.970 −53.618 1.00 34.86 C ATOM 2054 NZ LYS B 403 50.945 −41.502 −52.204 1.00 41.33 N ATOM 2055 C LYS B 403 49.918 −40.392 −58.824 1.00 17.70 C ATOM 2056 O LYS B 403 49.337 −39.300 −58.837 1.00 21.56 O ATOM 2057 N PHE B 404 49.330 −41.525 −59.184 1.00 19.40 N ATOM 2056 CA PHE B 404 47.900 −41.546 −59.496 1.00 19.48 C ATOM 2059 CB PHE B 404 47.654 −42.330 −60.764 1.00 21.50 C ATOM 2060 CG PHE B 404 48.033 −41.577 −61.997 1.00 19.10 C ATOM 2061 CD1 PHE B 404 47.132 −40.665 −62.572 1.00 19.05 C ATOM 2062 CE1 PHE B 404 47.500 −39.929 −63.720 1.00 21.95 C ATOM 2063 CZ PHE B 404 48.760 −40.098 −64.278 1.00 20.72 C ATOM 2064 CE2 PHE B 404 49.665 −41.015 −63.720 1.00 20.35 C ATOM 2065 CD2 PHE B 404 49.302 −41.747 −62.580 1.00 18.57 C ATOM 2066 C PHE B 404 47.131 −42.148 −58.350 1.00 22.07 C ATOM 2067 O PHE B 404 47.514 −43.171 −57.846 1.00 20.40 O ATOM 2066 N THR B 405 46.068 −41.475 −57.922 1.00 22.63 N ATOM 2069 CA THR B 405 45.309 −41.921 −56.760 1.00 21.98 C ATOM 2070 CB THR B 405 45.491 −40.938 −55.582 1.00 28.44 C ATOM 2071 OG1 THR B 405 45.236 −39.595 −56.031 1.00 28.02 O ATOM 2072 CG2 THR B 405 46.936 −41.031 −55.019 1.00 27.07 C ATOM 2073 C THR B 405 43.836 −42.050 −57.140 1.00 23.88 C ATOM 2074 O THR B 405 43.290 −41.168 −57.829 1.00 21.85 O ATOM 2075 N ALA B 406 43.189 −43.155 −56.709 1.00 21.65 N ATOM 2076 CA ALA B 406 41.806 −43.453 −57.144 1.00 21.78 C ATOM 2077 CB ALA B 406 41.422 −44.916 −56.823 1.00 22.43 C ATOM 2078 C ALA B 406 40.798 −42.492 −56.543 1.00 19.96 C ATOM 2079 O ALA B 406 40.925 −42.086 −55.421 1.00 28.14 O ATOM 2080 N THR B 407 39.803 −42.110 −57.328 1.00 23.19 N ATOM 2081 CA THR B 407 38.781 −41.206 −56.841 1.00 28.46 C ATOM 2082 CB THR B 407 38.201 −40.351 −57.986 1.00 30.35 C ATOM 2083 OG1 THR B 407 37.621 −41.212 −58.978 1.00 33.67 O ATOM 2084 CG2 THR B 407 39.309 −39.511 −58.641 1.00 30.01 C ATOM 2085 C THR B 407 37.644 −41.986 −56.151 1.00 31.47 C ATOM 2086 O THR B 407 36.855 −41.408 −55.416 1.00 33.47 O ATOM 2087 N LYS B 408 37.587 −43.299 −56.390 1.00 32.31 N ATOM 2088 CA LYS B 408 36.543 −44.186 −55.804 1.00 35.44 C ATOM 2089 CB LYS B 408 35.633 −44.750 −56.909 1.00 37.65 C ATOM 2090 CG LYS B 408 34.717 −43.734 −57.595 1.00 47.66 C ATOM 2091 CD LYS B 408 33.609 −43.223 −56.667 1.00 65.18 C ATOM 2092 CE LYS B 408 32.782 −44.358 −56.048 1.00 66.05 C ATOM 2093 NZ LYS B 408 32.197 −45.275 −57.070 1.00 63.73 N ATOM 2094 C LYS B 408 37.208 −45.354 −55.057 1.00 35.52 C ATOM 2095 O LYS B 408 38.211 −45.894 −55.513 1.00 27.55 O ATOM 2096 N LYS B 409 36.614 −45.772 −53.947 1.00 35.54 N ATOM 2097 CA LYS B 409 37.224 −46.790 −53.103 1.00 32.09 C ATOM 2098 CB LYS B 409 36.707 −46.687 −51.658 1.00 38.15 C ATOM 2099 CG LYS B 409 36.929 −45.313 −50.983 1.00 48.59 C ATOM 2100 CD LYS B 409 38.413 −44.890 −50.910 1.00 58.61 C ATOM 2101 CE LYS B 409 38.719 −43.598 −51.711 1.00 55.96 C ATOM 2102 NZ LYS B 409 39.614 −43.765 −52.928 1.00 32.94 N ATOM 2103 C LYS B 409 37.111 −48.225 −53.668 1.00 31.39 C ATOM 2104 O LYS B 409 37.875 −49.110 −53.277 1.00 31.57 O ATOM 2105 N ASP B 410 36.220 −48.440 −54.633 1.00 33.50 N ATOM 2106 CA ASP B 410 36.055 −49.787 −55.226 1.00 34.27 C ATOM 2107 CB ASP B 410 34.600 −50.016 −55.668 1.00 43.97 C ATOM 2108 CG ASP B 410 34.141 −49.037 −56.763 1.00 51.07 C ATOM 2109 OD1 ASP B 410 34.940 −48.178 −57.219 1.00 45.00 O ATOM 2110 OD2 ASP B 410 32.968 −49.144 −57.174 1.00 50.95 O ATOM 2111 C ASP B 410 37.034 −50.119 −56.376 1.00 37.51 C ATOM 2112 O ASP B 410 36.965 −51.192 −56.969 1.00 40.14 O ATOM 2113 N MET B 411 37.923 −49.181 −56.691 1.00 33.37 N ATOM 2114 CA MET B 411 38.947 −49.374 −57.735 1.00 30.15 C ATOM 2115 CB MET B 411 39.375 −47.980 −58.307 1.00 21.71 C ATOM 2116 CG MET B 411 38.208 −47.331 −59.054 1.00 35.80 C ATOM 2117 SD MET B 411 38.504 −45.709 −59.780 1.00 36.76 S ATOM 2118 CE MET B 411 38.578 −44.655 −58.375 1.00 30.18 C ATOM 2119 C MET B 411 40.158 −50.141 −57.173 1.00 29.10 C ATOM 2120 O MET B 411 40.427 −50.092 −55.980 1.00 25.37 O ATOM 2121 N SER B 412 40.843 −50.897 −58.027 1.00 30.07 N ATOM 2122 CA SER B 412 42.167 −51.416 −57.678 1.00 26.45 C ATOM 2123 CB SER B 412 42.163 −52.926 −57.501 1.00 27.50 C ATOM 2124 OG SER B 412 41.512 −53.527 −58.594 1.00 31.67 O ATOM 2125 C SER B 412 43.104 −50.979 −58.795 1.00 25.60 C ATOM 2126 O SER B 412 42.745 −51.157 −59.958 1.00 23.85 O ATOM 2127 N PRO B 413 44.393 −50.881 −58.473 1.00 21.41 N ATOM 2128 CA PRO B 413 44.883 −50.222 −57.289 1.00 19.98 C ATOM 2129 CB PRO B 413 46.396 −50.108 −57.558 1.00 20.19 C ATOM 2130 CG PRO B 413 46.478 −49.910 −59.013 1.00 20.26 C ATOM 2131 CD PRO B 413 45.251 −50.562 −59.638 1.00 19.68 C ATOM 2132 C PRO B 413 44.306 −48.915 −56.895 1.00 22.23 C ATOM 2133 O PRO B 413 43.914 −48.105 −57.746 1.00 23.82 O ATOM 2134 N GLN B 414 44.332 −48.661 −55.593 1.00 16.67 N ATOM 2135 CA GLN B 414 43.927 −47.397 −55.078 1.00 18.64 C ATOM 2136 CB GLN B 414 43.727 −47.465 −53.558 1.00 21.07 C ATOM 2137 CG GLN B 414 42.360 −48.072 −53.131 1.00 20.88 C ATOM 2138 CD GLN B 414 41.196 −47.200 −53.634 1.00 20.83 C ATOM 2139 OE1 GLN B 414 40.420 −47.564 −54.536 1.00 28.56 O ATOM 2140 NE2 GLN B 414 41.096 −46.038 −53.052 1.00 22.14 N ATOM 2141 C GLN B 414 44.943 −46.306 −55.457 1.00 18.17 C ATOM 2142 O GLN B 414 44.624 −45.137 −55.422 1.00 20.82 O ATOM 2143 N LYS B 415 46.157 −46.726 −55.780 1.00 18.50 N ATOM 2144 CA LYS B 415 47.218 −45.806 −56.187 1.00 20.24 C ATOM 2145 CB LYS B 415 47.776 −44.996 −54.998 1.00 25.82 C ATOM 2146 CG LYS B 415 48.725 −45.715 −54.106 1.00 34.82 C ATOM 2147 CD LYS B 415 50.132 −45.625 −54.666 1.00 29.51 C ATOM 2148 CE LYS B 415 51.058 −46.526 −53.859 1.00 35.54 C ATOM 2149 NZ LYS B 415 52.349 −46.704 −54.594 1.00 26.80 N ATOM 2150 C LYS B 415 48.285 −46.517 −56.963 1.00 18.95 C ATOM 2151 O LYS B 415 48.458 −47.741 −56.846 1.00 17.81 O ATOM 2152 N PHE B 416 48.945 −45.773 −57.852 1.00 19.20 N ATOM 2153 CA PHE B 416 50.093 −46.310 −58.623 1.00 16.41 C ATOM 2154 CB PHE B 416 49.631 −47.216 −59.784 1.00 16.68 C ATOM 2155 CG PHE B 416 48.860 −46.494 −60.864 1.00 17.67 C ATOM 2156 CD2 PHE B 416 49.519 −46.024 −62.010 1.00 18.03 C ATOM 2157 CE2 PHE B 416 48.817 −45.402 −63.029 1.00 17.05 C ATOM 2158 CZ PHE B 416 47.455 −45.149 −62.877 1.00 19.28 C ATOM 2159 CE1 PHE B 416 46.782 −45.615 −61.752 1.00 20.02 C ATOM 2160 CD1 PHE B 416 47.484 −46.272 −60.741 1.00 19.52 C ATOM 2161 C PHE B 416 50.909 −45.127 −59.129 1.00 14.06 C ATOM 2162 O PHE B 416 50.555 −43.975 −58.847 1.00 19.21 O ATOM 2163 N TRP B 417 52.009 −45.410 −59.813 1.00 16.50 N ATOM 2164 CA TRP B 417 52.871 −44.341 −60.367 1.00 19.40 C ATOM 2165 CB TRP B 417 54.288 −44.461 −59.824 1.00 16.84 C ATOM 2166 CG TRP B 417 54.305 −44.441 −58.305 1.00 17.04 C ATOM 2167 CD1 TRP B 417 54.069 −45.512 −57.439 1.00 18.41 C ATOM 2168 NE1 TRP B 417 54.161 −45.102 −56.124 1.00 20.34 N ATOM 2169 CE2 TRP B 417 54.435 −43.757 −56.083 1.00 23.03 C ATOM 2170 CD2 TRP B 417 54.523 −43.291 −57.467 1.00 19.05 C ATOM 2171 CE3 TRP B 417 54.826 −41.940 −57.716 1.00 18.50 C ATOM 2172 CZ3 TRP B 417 54.985 −41.075 −56.626 1.00 21.97 C ATOM 2173 CH2 TRP B 417 54.879 −41.539 −55.298 1.00 23.62 C ATOM 2174 CZ2 TRP B 417 54.603 −42.898 −55.004 1.00 22.75 C ATOM 2175 C TRP B 417 52.911 −44.479 −61.833 1.00 21.48 C ATOM 2176 O TRP B 417 53.107 −45.590 −62.349 1.00 19.86 O ATOM 2177 N GLY B 418 52.716 −43.357 −62.535 1.00 21.50 N ATOM 2178 CA GLY B 418 52.894 −43.355 −63.988 1.00 22.82 C ATOM 2179 C GLY B 418 54.175 −42.600 −64.237 1.00 22.57 C ATOM 2180 O GLY B 418 54.285 −41.433 −63.840 1.00 22.33 O ATOM 2181 N LEU B 419 55.163 −43.267 −64.825 1.00 18.90 N ATOM 2182 CA LEU B 419 56.510 −42.673 −64.906 1.00 18.11 C ATOM 2183 CB LEU B 419 57.560 −43.552 −64.185 1.00 18.20 C ATOM 2184 CG LEU B 419 57.233 −43.892 −62.708 1.00 17.73 C ATOM 2185 CD1 LEU B 419 58.261 −44.872 −62.171 1.00 22.72 C ATOM 2186 CD2 LEU B 419 57.198 −42.639 −61.821 1.00 18.32 C ATOM 2187 C LEU B 419 56.908 −42.455 −66.362 1.00 20.23 C ATOM 2188 O LEU B 419 56.676 −43.309 −67.219 1.00 24.57 O ATOM 2189 N THR B 420 57.578 −41.336 −66.621 1.00 22.71 N ATOM 2190 CA THR B 420 58.031 −41.043 −67.974 1.00 23.72 C ATOM 2191 CB THR B 420 58.313 −39.541 −68.149 1.00 22.08 C ATOM 2192 OG1 THR B 420 57.126 −38.824 −67.824 1.00 23.21 O ATOM 2193 CG2 THR B 420 58.704 −39.237 −69.607 1.00 24.82 C ATOM 2194 C THR B 420 59.234 −41.880 −68.307 1.00 22.37 C ATOM 2195 O THR B 420 60.303 −41.730 −67.693 1.00 24.14 O ATOM 2196 N ARG B 421 59.069 −42.810 −69.247 1.00 21.72 N ATOM 2197 CA ARG B 421 60.124 −43.792 −69.511 1.00 27.49 C ATOM 2198 CB ARG B 421 59.752 −44.714 −70.650 1.00 29.41 C ATOM 2199 CG ARG B 421 58.946 −45.913 −70.252 1.00 35.70 C ATOM 2200 CD ARG B 421 58.671 −46.773 −71.474 1.00 41.16 C ATOM 2201 NE ARG B 421 57.613 −47.735 −71.219 1.00 55.06 N ATOM 2202 CZ ARG B 421 57.727 −49.045 −71.403 1.00 66.07 C ATOM 2203 NH1 ARG B 421 58.859 −49.561 −71.868 1.00 72.67 N ATOM 2204 NH2 ARG B 421 56.697 −49.838 −71.140 1.00 75.15 N ATOM 2205 C ARG B 421 61.449 −43.113 −69.868 1.00 29.60 C ATOM 2206 O ARG B 421 62.520 −43.628 −69.544 1.00 23.60 O ATOM 2207 N SER B 422 61.362 −41.970 −70.559 1.00 29.08 N ATOM 2208 CA SER B 422 62.559 −41.286 −71.027 1.00 30.42 C ATOM 2209 CB SER B 422 62.232 −40.289 −72.158 1.00 28.03 C ATOM 2210 OG SER B 422 61.377 −39.255 −71.726 1.00 35.09 O ATOM 2211 C SER B 422 63.281 −40.595 −69.878 1.00 31.76 C ATOM 2212 O SER B 422 64.412 −40.199 −70.036 1.00 30.97 O ATOM 2213 N ALA B 423 62.624 −40.500 −68.702 1.00 23.51 N ATOM 2214 CA ALA B 423 63.254 −39.929 −67.505 1.00 23.73 C ATOM 2215 CB ALA B 423 62.236 −39.137 −66.686 1.00 24.71 C ATOM 2216 C ALA B 423 63.995 −40.944 −66.614 1.00 23.11 C ATOM 2217 O ALA B 423 64.493 −40.584 −65.549 1.00 22.70 O ATOM 2218 N LEU B 424 64.078 −42.192 −67.066 1.00 23.23 N ATOM 2219 CA LEU B 424 64.720 −43.263 −66.298 1.00 21.80 C ATOM 2220 CB LEU B 424 63.680 −44.331 −65.891 1.00 23.22 C ATOM 2221 CG LEU B 424 62.499 −43.818 −65.049 1.00 20.38 C ATOM 2222 CD1 LEU B 424 61.370 −44.844 −65.013 1.00 24.99 C ATOM 2223 CD2 LEU B 424 62.951 −43.441 −63.634 1.00 21.85 C ATOM 2224 C LEU B 424 65.810 −43.918 −67.113 1.00 27.47 C ATOM 2225 O LEU B 424 65.751 −43.908 −68.345 1.00 29.56 O ATOM 2226 N LEU B 425 66.784 −44.517 −66.416 1.00 29.62 N ATOM 2227 CA LEU B 425 67.863 −45.284 −67.043 1.00 35.64 C ATOM 2228 CB LEU B 425 69.214 −44.716 −66.653 1.00 36.39 C ATOM 2229 CG LEU B 425 70.221 −44.498 −67.783 1.00 48.35 C ATOM 2230 CD1 LEU B 425 69.553 −43.945 −69.041 1.00 44.47 C ATOM 2231 CD2 LEU B 425 71.308 −43.554 −67.297 1.00 48.49 C ATOM 2232 C LEU B 425 67.773 −46.742 −66.615 1.00 42.74 C ATOM 2233 O LEU B 425 67.237 −47.014 −65.558 1.00 43.56 O ATOM 2234 N PRO B 426 68.532 −47.632 −67.296 1.00 56.39 N ATOM 2235 CA PRO B 426 67.955 −48.535 −68.250 1.00 49.52 C ATOM 2236 CB PRO B 426 67.596 −49.736 −67.386 1.00 49.11 C ATOM 2237 CG PRO B 426 68.725 −49.762 −66.354 1.00 47.03 C ATOM 2238 CD PRO B 426 69.431 −48.396 −66.424 1.00 62.58 C ATOM 2239 C PRO B 426 66.762 −47.901 −68.955 1.00 57.15 C ATOM 2240 O PRO B 426 65.754 −47.569 −68.323 1.00 44.27 O ATOM 2241 N THR B 427 66.913 −47.680 −70.254 1.00 60.10 N ATOM 2242 CA THR B 427 66.055 −46.754 −70.968 1.00 64.18 C ATOM 2243 CB THR B 427 66.752 −45.366 −71.114 1.00 71.13 C ATOM 2244 OG1 THR B 427 65.770 −44.317 −71.233 1.00 52.24 O ATOM 2245 CG2 THR B 427 67.724 −45.346 −72.311 1.00 58.56 C ATOM 2246 C THR B 427 65.656 −47.319 −72.336 1.00 76.11 C ATOM 2247 O THR B 427 65.371 −48.513 −72.465 1.00 75.97 O ATOM 2248 N THR D 321 67.953 −14.879 −79.916 1.00 44.44 N ATOM 2249 CA THR D 321 66.490 −15.242 −79.994 1.00 39.62 C ATOM 2250 CB THR D 321 65.714 −14.372 −81.008 1.00 41.63 C ATOM 2251 OG1 THR D 321 66.212 −14.609 −82.320 1.00 45.50 O ATOM 2252 CG2 THR D 321 65.804 −12.871 −80.664 1.00 49.40 C ATOM 2253 C THR D 321 66.228 −16.721 −80.355 1.00 33.66 C ATOM 2254 O THR D 321 65.101 −17.154 −80.357 1.00 27.86 O ATOM 2255 N SER D 322 67.268 −17.485 −80.662 1.00 28.46 N ATOM 2256 CA SER D 322 67.068 −18.900 −81.008 1.00 30.21 C ATOM 2257 CB SER D 322 68.297 −19.449 −81.697 1.00 27.30 C ATOM 2258 OG SER D 322 68.479 −18.814 −82.931 1.00 34.80 O ATOM 2259 C SER D 322 66.718 −19.765 −79.796 1.00 29.25 C ATOM 2260 O SER D 322 67.366 −19.677 −78.751 1.00 28.20 O ATOM 2261 N LEU D 323 65.687 −20.607 −79.940 1.00 25.22 N ATOM 2262 CA LEU D 323 65.379 −21.626 −78.929 1.00 22.92 C ATOM 2263 CB LEU D 323 63.920 −21.545 −78.466 1.00 19.72 C ATOM 2264 CG LEU D 323 63.493 −20.156 −77.949 1.00 28.78 C ATOM 2265 CD1 LEU D 323 62.035 −20.148 −77.553 1.00 30.40 C ATOM 2266 CD2 LEU D 323 64.346 −19.694 −76.781 1.00 33.30 C ATOM 2267 C LEU D 323 65.683 −23.002 −79.490 1.00 23.34 C ATOM 2268 O LEU D 323 65.066 −23.429 −80.458 1.00 24.04 O ATOM 2269 N CYS D 324 66.656 −23.677 −78.884 1.00 25.44 N ATOM 2270 CA CYS D 324 67.222 −24.907 −79.436 1.00 25.51 C ATOM 2271 CB CYS D 324 68.754 −24.799 −79.453 1.00 23.78 C ATOM 2272 SG CYS D 324 69.309 −23.636 −80.701 1.00 32.31 S ATOM 2273 C CYS D 324 66.837 −26.134 −78.649 1.00 21.89 C ATOM 2274 O CYS D 324 66.594 −26.057 −77.442 1.00 23.78 O ATOM 2275 N CYS D 325 66.823 −27.276 −79.324 1.00 19.89 N ATOM 2276 CA CYS D 325 66.635 −28.546 −78.645 1.00 23.67 C ATOM 2277 CB CYS D 325 66.755 −29.697 −79.654 1.00 18.79 C ATOM 2278 SG CYS D 325 66.731 −31.343 −78.903 1.00 23.84 S ATOM 2279 C CYS D 325 67.689 −28.693 −77.518 1.00 26.11 C ATOM 2280 O CYS D 325 68.884 −28.610 −77.769 1.00 27.69 O ATOM 2281 N LYS D 326 67.236 −28.929 −76.290 1.00 25.67 N ATOM 2282 CA LYS D 326 68.162 −29.078 −75.151 1.00 24.80 C ATOM 2283 CB LYS D 326 67.385 −29.235 −73.856 1.00 28.45 C ATOM 2284 CG LYS D 326 68.255 −29.277 −72.603 1.00 29.89 C ATOM 2285 CD LYS D 326 67.404 −29.350 −71.343 1.00 31.48 C ATOM 2286 CE LYS D 326 66.716 −30.702 −71.213 1.00 43.44 C ATOM 2287 NZ LYS D 326 66.101 −30.908 −69.864 1.00 56.07 N ATOM 2288 C LYS D 326 69.120 −30.267 −75.335 1.00 29.95 C ATOM 2289 O LYS D 326 70.288 −30.197 −74.942 1.00 28.84 O ATOM 2290 N GLN D 327 68.634 −31.330 −75.961 1.00 24.61 N ATOM 2291 CA GLN D 327 69.411 −32.598 −76.081 1.00 29.81 C ATOM 2292 CB GLN D 327 68.488 −33.795 −76.367 1.00 25.61 C ATOM 2293 CG GLN D 327 69.194 −35.046 −76.892 1.00 35.40 C ATOM 2294 CD GLN D 327 70.008 −35.742 −75.822 1.00 44.68 C ATOM 2295 OE1 GLN D 327 69.738 −35.583 −74.630 1.00 35.09 O ATOM 2296 NE2 GLN D 327 71.029 −36.508 −76.240 1.00 40.17 N ATOM 2297 C GLN D 327 70.542 −32.540 −77.114 1.00 33.25 C ATOM 2298 O GLN D 327 71.669 −32.899 −76.808 1.00 27.19 O ATOM 2299 N CYS D 328 70.239 −32.134 −78.347 1.00 27.64 N ATOM 2300 CA CYS D 328 71.279 −32.080 −79.368 1.00 30.83 C ATOM 2301 CB CYS D 328 70.766 −32.574 −80.720 1.00 33.24 C ATOM 2302 SG CYS D 328 69.439 −31.547 −81.421 1.00 27.36 S ATOM 2303 C CYS D 328 71.915 −30.692 −79.469 1.00 27.65 C ATOM 2304 O CYS D 328 72.922 −30.516 −80.155 1.00 29.26 O ATOM 2305 N GLN D 329 71.337 −29.726 −78.758 1.00 24.10 N ATOM 2306 CA GLN D 329 71.948 −28.408 −78.521 1.00 27.95 C ATOM 2307 CB GLN D 329 73.332 −28.549 −77.843 1.00 31.61 C ATOM 2308 CG GLN D 329 73.307 −29.476 −76.620 1.00 28.22 C ATOM 2309 CD GLN D 329 74.666 −29.638 −75.948 1.00 39.75 C ATOM 2310 OE1 GLN D 329 75.308 −28.659 −75.569 1.00 36.77 O ATOM 2311 NE2 GLN D 329 75.095 −30.883 −75.780 1.00 42.28 N ATOM 2312 C GLN D 329 72.018 −27.461 −79.743 1.00 29.87 C ATOM 2313 O GLN D 329 71.900 −26.246 −79.588 1.00 43.02 O ATOM 2314 N GLU D 330 72.143 −28.024 −80.935 1.00 29.98 N ATOM 2315 CA GLU D 330 72.464 −27.255 −82.132 1.00 40.03 C ATOM 2316 CB GLU D 330 73.475 −28.015 −83.004 1.00 46.93 C ATOM 2317 CG GLU D 330 74.854 −28.177 −82.375 1.00 61.31 C ATOM 2318 CD GLU D 330 75.483 −26.849 −82.009 1.00 71.59 C ATOM 2319 OE1 GLU D 330 75.537 −26.528 −80.800 1.00 74.82 O ATOM 2320 OE2 GLU D 330 75.901 −26.115 −82.932 1.00 84.62 O ATOM 2321 C GLU D 330 71.233 −26.936 −82.976 1.00 36.38 C ATOM 2322 O GLU D 330 71.265 −26.028 −83.815 1.00 34.33 O ATOM 2323 N THR D 331 70.175 −27.703 −82.782 1.00 27.07 N ATOM 2324 CA THR D 331 69.036 −27.665 −83.694 1.00 26.59 C ATOM 2325 CB THR D 331 68.374 −29.045 −83.785 1.00 30.74 C ATOM 2326 OG1 THR D 331 69.347 −30.004 −84.252 1.00 31.83 O ATOM 2327 CG2 THR D 331 67.191 −29.025 −84.732 1.00 23.43 C ATOM 2328 C THR D 331 68.044 −26.636 −83.185 1.00 26.22 C ATOM 2329 O THR D 331 67.502 −26.763 −82.069 1.00 20.96 O ATOM 2330 N GLU D 332 67.812 −25.609 −83.992 1.00 21.63 N ATOM 2331 CA GLU D 332 66.864 −24.563 −83.633 1.00 22.42 C ATOM 2332 CB GLU D 332 67.072 −23.322 −84.508 1.00 23.45 C ATOM 2333 CG GLU D 332 66.102 −22.208 −84.131 1.00 24.23 C ATOM 2334 CD GLU D 332 66.234 −21.014 −85.022 1.00 28.65 C ATOM 2335 OE1 GLU D 332 67.171 −20.229 −84.813 1.00 25.99 O ATOM 2336 OE2 GLU D 332 65.396 −20.875 −85.924 1.00 24.99 O ATOM 2337 C GLU D 332 65.432 −25.071 −83.797 1.00 21.70 C ATOM 2338 O GLU D 332 65.072 −25.599 −84.857 1.00 24.48 O ATOM 2339 N ILE D 333 64.618 −24.923 −82.753 1.00 16.36 N ATOM 2340 CA ILE D 333 63.216 −25.408 −82.838 1.00 16.17 C ATOM 2341 CB ILE D 333 62.793 −26.196 −81.594 1.00 17.10 C ATOM 2342 CG1 ILE D 333 63.751 −27.384 −81.383 1.00 20.80 C ATOM 2343 CD1 ILE D 333 63.748 −28.384 −82.536 1.00 17.38 C ATOM 2344 CG2 ILE D 333 61.336 −26.656 −81.729 1.00 17.71 C ATOM 2345 C ILE D 333 62.222 −24.270 −83.074 1.00 18.22 C ATOM 2346 O ILE D 333 61.250 −24.436 −83.813 1.00 18.73 O ATOM 2347 N THR D 334 62.449 −23.150 −82.408 1.00 20.52 N ATOM 2348 CA THR D 334 61.643 −21.931 −82.659 1.00 21.42 C ATOM 2349 CB THR D 334 60.296 −21.945 −81.878 1.00 21.16 C ATOM 2350 OG1 THR D 334 59.470 −20.838 −82.304 1.00 21.42 O ATOM 2351 CG2 THR D 334 60.540 −21.840 −80.395 1.00 18.90 C ATOM 2352 C THR D 334 62.496 −20.717 −82.317 1.00 21.10 C ATOM 2353 O THR D 334 63.682 −20.858 −82.028 1.00 19.46 O ATOM 2354 N THR D 335 61.921 −19.529 −82.405 1.00 19.83 N ATOM 2355 CA THR D 335 62.616 −18.352 −81.969 1.00 23.05 C ATOM 2356 CB THR D 335 62.988 −17.452 −83.153 1.00 22.99 C ATOM 2357 OG1 THR D 335 61.812 −16.844 −83.660 1.00 26.04 O ATOM 2358 CG2 THR D 335 63.651 −18.256 −84.272 1.00 24.90 C ATOM 2359 C THR D 335 61.744 −17.564 −81.003 1.00 21.50 C ATOM 2360 O THR D 335 60.492 −17.721 −80.976 1.00 20.48 O ATOM 2361 N LYS D 336 62.368 −16.691 −80.232 1.00 19.92 N ATOM 2362 CA LYS D 336 61.586 −15.802 −79.342 1.00 22.50 C ATOM 2363 CB LYS D 336 62.503 −14.888 −78.548 1.00 22.50 C ATOM 2364 CG LYS D 336 63.178 −15.542 −77.349 1.00 32.98 C ATOM 2365 CD LYS D 336 64.027 −14.507 −76.621 1.00 32.46 C ATOM 2366 CE LYS D 336 64.581 −15.052 −75.321 1.00 42.54 C ATOM 2367 NZ LYS D 336 65.145 −13.950 −74.506 1.00 47.55 N ATOM 2368 C LYS D 336 60.537 −14.964 −80.114 1.00 20.92 C ATOM 2369 O LYS D 336 59.489 −14.613 −79.567 1.00 18.93 O ATOM 2370 N ASN D 337 60.822 −14.641 −81.372 1.00 17.68 N ATOM 2371 CA ASN D 337 59.892 −13.849 −82.177 1.00 21.09 C ATOM 2372 CB ASN D 337 60.540 −13.435 −83.497 1.00 19.30 C ATOM 2373 CG ASN D 337 61.855 −12.703 −83.290 1.00 32.88 C ATOM 2374 OD1 ASN D 337 62.919 −13.201 −83.655 1.00 38.62 O ATOM 2375 ND2 ASN D 337 61.797 −11.572 −82.618 1.00 32.56 N ATOM 2376 C ASN D 337 58.553 −14.559 −82.448 1.00 19.23 C ATOM 2377 O ASN D 337 57.565 −13.918 −82.805 1.00 17.93 O ATOM 2378 N GLU D 338 58.540 −15.880 −82.312 1.00 16.14 N ATOM 2379 CA GLU D 338 57.346 −16.678 −82.630 1.00 16.54 C ATOM 2380 CB GLU D 338 57.743 −18.046 −83.234 1.00 21.08 C ATOM 2381 CG GLU D 338 58.497 −17.934 −84.552 1.00 21.82 C ATOM 2382 CD GLU D 338 57.808 −16.994 −85.526 1.00 28.91 C ATOM 2383 OE1 GLU D 338 56.576 −17.126 −85.728 1.00 24.73 O ATOM 2384 OE2 GLU D 338 58.496 −16.123 −86.090 1.00 34.64 O ATOM 2385 C GLU D 338 56.429 −16.872 −81.442 1.00 17.76 C ATOM 2386 O GLU D 338 55.300 −17.345 −81.587 1.00 16.91 O ATOM 2387 N ILE D 339 56.880 −16.440 −80.270 1.00 18.50 N ATOM 2388 CA ILE D 339 56.131 −16.659 −79.035 1.00 17.47 C ATOM 2389 CB ILE D 339 56.983 −16.291 −77.792 1.00 19.50 C ATOM 2390 CG1 ILE D 339 58.180 −17.257 −77.657 1.00 20.60 C ATOM 2391 CD1 ILE D 339 59.169 −16.849 −76.562 1.00 21.66 C ATOM 2392 CG2 ILE D 339 56.126 −16.311 −76.537 1.00 20.45 C ATOM 2393 C ILE D 339 54.838 −15.832 −78.992 1.00 18.80 C ATOM 2394 O ILE D 339 54.835 −14.644 −79.351 1.00 17.55 O ATOM 2395 N PHE D 340 53.743 −16.464 −78.577 1.00 14.25 N ATOM 2396 CA PHE D 340 52.483 −15.735 −78.373 1.00 18.16 C ATOM 2397 CB PHE D 340 51.594 −15.734 −79.655 1.00 14.54 C ATOM 2398 CG PHE D 340 50.872 −17.032 −79.914 1.00 16.30 C ATOM 2399 CD2 PHE D 340 49.497 −17.147 −79.675 1.00 17.44 C ATOM 2400 CE2 PHE D 340 48.815 −18.342 −79.926 1.00 17.02 C ATOM 2401 CZ PHE D 340 49.509 −19.464 −80.427 1.00 20.18 C ATOM 2402 CE1 PHE D 340 50.881 −19.358 −80.714 1.00 15.15 C ATOM 2403 CD1 PHE D 340 51.567 -18.169 −80.438 1.00 16.03 C ATOM 2404 C PHE D 340 51.766 −16.347 −77.206 1.00 20.74 C ATOM 2405 O PHE D 340 52.199 −17.383 −76.692 1.00 19.13 O ATOM 2406 N SER D 341 50.691 −15.695 −76.756 1.00 19.60 N ATOM 2407 CA SER D 341 49.922 −16.213 −75.619 1.00 23.90 C ATOM 2408 CB SER D 341 49.864 −15.170 −74.495 1.00 27.38 C ATOM 2409 OG SER D 341 49.295 −15.727 −73.316 1.00 35.12 O ATOM 2410 C SER D 341 48.542 −16.648 −76.027 1.00 22.50 C ATOM 2411 O SER D 341 47.650 −15.842 −76.184 1.00 25.37 O ATOM 2412 N LEU D 342 48.391 −17.937 −76.286 1.00 25.13 N ATOM 2413 CA LEU D 342 47.095 −18.505 −76.597 1.00 24.94 C ATOM 2414 CB LEU D 342 47.248 −19.963 −77.072 1.00 25.61 C ATOM 2415 CG LEU D 342 46.045 −20.630 −77.755 1.00 31.69 C ATOM 2416 CD1 LEU D 342 44.980 −21.046 −76.754 1.00 32.58 C ATOM 2417 CD2 LEU D 342 45.448 −19.691 −78.793 1.00 34.18 C ATOM 2418 C LEU D 342 46.251 −18.440 −75.334 1.00 29.27 C ATOM 2419 O LEU D 342 45.120 −17.918 −75.346 1.00 23.49 O ATOM 2420 N SER D 343 46.824 −18.928 −74.228 1.00 28.36 N ATOM 2421 CA ASER D 343 46.144 −18.902 −72.949 0.50 30.32 C ATOM 2422 CA BSER D 343 46.155 −18.901 −72.937 0.50 29.33 C ATOM 2423 CB ASER D 343 46.865 −19.803 −71.937 0.50 31.29 C ATOM 2424 CB BSER D 343 46.896 −19.788 −71.915 0.50 28.18 C ATOM 2425 OG ASER D 343 48.130 −19.263 −71.611 0.50 29.93 O ATOM 2426 OG BSER D 343 47.057 −21.106 −72.399 0.50 23.67 O ATOM 2427 C SER D 343 46.099 −17.471 −72.423 1.00 33.93 C ATOM 2428 O SER D 343 47.004 −16.672 −72.691 1.00 31.24 O ATOM 2429 N LEU D 344 45.043 −17.155 −71.682 1.00 29.96 N ATOM 2430 CA LEU D 344 44.870 −15.825 −71.090 1.00 35.32 C ATOM 2431 CB LEU D 344 43.574 −15.767 −70.271 1.00 35.61 C ATOM 2432 CG LEU D 344 42.285 −16.016 −71.070 1.00 50.21 C ATOM 2433 CD1 LEU D 344 41.083 −15.968 −70.144 1.00 52.66 C ATOM 2434 CD2 LEU D 344 42.120 −15.041 −72.237 1.00 39.69 C ATOM 2435 C LEU D 344 46.042 −15.401 −70.213 1.00 40.17 C ATOM 2436 O LEU D 344 46.648 −16.233 −69.502 1.00 33.33 O ATOM 2437 N CYS D 345 46.310 −14.092 −70.234 1.00 46.57 N ATOM 2438 CA CYS D 345 47.419 −13.465 −69.508 1.00 54.22 C ATOM 2439 CB CYS D 345 48.094 −12.396 −70.392 1.00 54.37 C ATOM 2440 SG CYS D 345 47.985 −12.684 −72.182 1.00 58.02 S ATOM 2441 C CYS D 345 46.905 −12.795 −68.231 1.00 61.31 C ATOM 2442 O CYS D 345 45.689 −12.747 −67.986 1.00 53.83 O ATOM 2443 N GLY D 346 47.832 −12.259 −67.434 1.00 61.51 N ATOM 2444 CA GLY D 346 47.478 −11.492 −66.231 1.00 56.35 C ATOM 2445 C GLY D 346 46.978 −12.357 −65.079 1.00 54.40 C ATOM 2446 O GLY D 346 47.476 −13.476 −64.870 1.00 54.53 O ATOM 2447 N PRO D 347 45.995 −11.837 −64.307 1.00 45.88 N ATOM 2448 CA PRO D 347 45.462 −12.549 −63.128 1.00 46.75 C ATOM 2449 CB PRO D 347 44.562 −11.492 −62.449 1.00 45.71 C ATOM 2450 CG PRO D 347 45.040 −10.173 −62.984 1.00 49.98 C ATOM 2451 CD PRO D 347 45.492 −10.450 −64.389 1.00 50.19 C ATOM 2452 C PRO D 347 44.656 −13.826 −63.466 1.00 43.50 C ATOM 2453 O PRO D 347 44.261 −14.554 −62.559 1.00 54.05 O ATOM 2454 N MET D 348 44.414 −14.079 −64.759 1.00 36.05 N ATOM 2455 CA MET D 348 43.774 −15.327 −65.193 1.00 39.70 C ATOM 2456 CB MET D 348 42.900 −15.097 −66.425 1.00 40.80 C ATOM 2457 CG MET D 348 41.527 −14.504 −66.099 1.00 36.76 C ATOM 2458 SD MET D 348 40.487 −15.594 −65.099 1.00 39.12 S ATOM 2459 CE MET D 348 40.536 −17.091 −66.102 1.00 40.07 C ATOM 2460 C MET D 348 44.765 −16.477 −65.442 1.00 37.01 C ATOM 2461 O MET D 348 44.362 −17.636 −65.479 1.00 38.01 O ATOM 2462 N ALA D 349 46.052 −16.146 −65.602 1.00 40.94 N ATOM 2463 CA ALA D 349 47.106 −17.163 −65.881 1.00 53.94 C ATOM 2464 CB ALA D 349 48.487 −16.512 −65.917 1.00 47.04 C ATOM 2465 C ALA D 349 47.083 −18.346 −64.881 1.00 58.15 C ATOM 2466 O ALA D 349 47.228 −19.520 −65.273 1.00 46.82 O ATOM 2467 N ALA D 350 46.859 −18.023 −63.603 1.00 57.24 N ATOM 2468 CA ALA D 350 46.805 −19.015 −62.530 1.00 52.59 C ATOM 2469 CB ALA D 350 46.872 −18.319 −61.167 1.00 48.28 C ATOM 2470 C ALA D 350 45.565 −19.931 −62.617 1.00 57.05 C ATOM 2471 O ALA D 350 45.547 −21.021 −62.039 1.00 46.40 O ATOM 2472 N TYR D 351 44.539 −19.490 −63.348 1.00 48.21 N ATOM 2473 CA TYR D 351 43.288 −20.250 −63.450 1.00 47.97 C ATOM 2474 CB TYR D 351 42.085 −19.308 −63.421 1.00 53.85 C ATOM 2475 CG TYR D 351 41.795 −18.780 −62.047 1.00 48.98 C ATOM 2476 CD2 TYR D 351 40.910 −19.451 −61.194 1.00 50.32 C ATOM 2477 CE2 TYR D 351 40.658 −18.978 −59.915 1.00 50.03 C ATOM 2478 CZ TYR D 351 41.306 −17.820 −59.477 1.00 53.88 C ATOM 2479 OH TYR D 351 41.069 −17.338 −58.222 1.00 61.26 O ATOM 2480 CE1 TYR D 351 42.195 −17.149 −60.301 1.00 50.73 C ATOM 2481 CD1 TYR D 351 42.434 −17.630 −61.575 1.00 49.23 C ATOM 2482 C TYR D 351 43.206 −21.152 −64.678 1.00 54.85 C ATOM 2483 O TYR D 351 42.379 −22.068 −64.733 1.00 63.23 O ATOM 2484 N VAL D 352 44.051 −20.887 −65.665 1.00 47.99 N ATOM 2485 CA VAL D 352 43.874 −21.496 −66.989 1.00 45.26 C ATOM 2486 CB VAL D 352 44.149 −20.479 −68.160 1.00 38.21 C ATOM 2487 CG1 VAL D 352 43.183 −19.294 −68.075 1.00 36.70 C ATOM 2488 CG2 VAL D 352 45.584 −19.981 −68.135 1.00 38.85 C ATOM 2489 C VAL D 352 44.647 −22.840 −67.142 1.00 38.08 C ATOM 2490 O VAL D 352 44.361 −23.622 −68.051 1.00 41.25 O ATOM 2491 N ASN D 353 45.586 −23.110 −66.227 1.00 33.57 N ATOM 2492 CA ASN D 353 46.250 −24.448 −66.155 1.00 37.20 C ATOM 2493 CB ASN D 353 47.678 −24.391 −66.708 1.00 43.06 C ATOM 2494 CG ASN D 353 47.717 −24.339 −68.221 1.00 42.18 C ATOM 2495 OD1 ASN D 353 47.416 −25.324 −68.903 1.00 38.05 O ATOM 2496 ND2 ASN D 353 48.093 −23.192 −68.755 1.00 38.82 N ATOM 2497 C ASN D 353 46.289 −24.941 −64.714 1.00 43.29 C ATOM 2498 O ASN D 353 46.186 −24.121 −63.785 1.00 41.95 O ATOM 2499 N PRO D 354 46.463 −26.275 −64.511 1.00 47.24 N ATOM 2500 CA PRO D 354 46.615 −26.790 −63.134 1.00 46.91 C ATOM 2501 CB PRO D 354 46.833 −28.306 −63.333 1.00 40.94 C ATOM 2502 CG PRO D 354 46.448 −28.598 −64.748 1.00 44.08 C ATOM 2503 CD PRO D 354 46.659 −27.333 −65.525 1.00 46.85 C ATOM 2504 C PRO D 354 47.842 −26.174 −62.464 1.00 45.55 C ATOM 2505 O PRO D 354 48.786 −25.777 −63.152 1.00 39.56 O ATOM 2506 N HIS D 355 47.829 −26.079 −61.134 1.00 45.30 N ATOM 2507 CA HIS D 355 49.045 −25.721 −60.403 1.00 45.87 C ATOM 2508 CB HIS D 355 48.789 −25.685 −58.900 1.00 49.39 C ATOM 2509 CG HIS D 355 47.640 −24.783 −58.499 1.00 71.56 C ATOM 2510 ND1 HIS D 355 47.389 −23.605 −59.113 1.00 80.15 N ATOM 2511 CE1 HIS D 355 46.310 −23.028 −58.549 1.00 77.53 C ATOM 2512 NE2 HIS D 355 45.870 −23.831 −57.567 1.00 79.81 N ATOM 2513 CD2 HIS D 355 46.666 −24.922 −57.506 1.00 78.62 C ATOM 2514 C HIS D 355 50.120 −26.723 −60.740 1.00 44.54 C ATOM 2515 O HIS D 355 49.828 −27.923 −60.930 1.00 33.48 O ATOM 2516 N GLY D 356 51.359 −26.239 −60.857 1.00 37.58 N ATOM 2517 CA GLY D 356 52.482 −27.058 −61.322 1.00 40.85 C ATOM 2518 C GLY D 356 52.776 −26.852 −62.808 1.00 38.27 C ATOM 2519 O GLY D 356 53.879 −27.122 −63.262 1.00 38.29 O ATOM 2520 N TYR D 357 51.784 −26.370 −63.561 1.00 31.59 N ATOM 2521 CA TYR D 357 51.902 −26.289 −65.033 1.00 35.46 C ATOM 2522 CB TYR D 357 51.007 −27.336 −65.703 1.00 32.29 C ATOM 2523 CG TYR D 357 51.494 −28.757 −65.507 1.00 28.76 C ATOM 2524 CD1 TYR D 357 52.816 −29.104 −65.791 1.00 33.11 C ATOM 2525 CE1 TYR D 357 53.278 −30.410 −65.607 1.00 30.23 C ATOM 2526 CZ TYR D 357 52.407 −31.378 −65.148 1.00 29.53 C ATOM 2527 OH TYR D 357 52.882 −32.673 −64.972 1.00 29.44 O ATOM 2528 CE2 TYR D 357 51.089 −31.067 −64.872 1.00 26.99 C ATOM 2529 CD2 TYR D 357 50.635 −29.756 −65.043 1.00 26.63 C ATOM 2530 C TYR D 357 51.616 −24.909 −65.635 1.00 43.94 C ATOM 2531 O TYR D 357 51.441 −24.778 −66.871 1.00 37.75 O ATOM 2532 N VAL D 358 51.581 −23.885 −64.787 1.00 38.84 N ATOM 2533 CA VAL D 358 51.235 −22.529 −65.247 1.00 43.50 C ATOM 2534 CB VAL D 358 51.033 −21.528 −64.072 1.00 51.57 C ATOM 2535 CG1 VAL D 358 49.913 −22.004 −63.138 1.00 45.44 C ATOM 2536 CG2 VAL D 358 52.336 −21.316 −63.306 1.00 52.19 C ATOM 2537 C VAL D 358 52.251 −21.991 −66.275 1.00 47.53 C ATOM 2538 O VAL D 358 51.880 −21.235 −67.172 1.00 52.85 O ATOM 2539 N HIS D 359 53.512 −22.422 −66.162 1.00 44.52 N ATOM 2540 CA HIS D 359 54.570 −21.985 −67.076 1.00 43.78 C ATOM 2541 CB HIS D 359 55.583 −21.106 −66.334 1.00 65.42 C ATOM 2542 CG HIS D 359 55.198 −19.644 −66.278 1.00 82.70 C ATOM 2543 ND1 HIS D 359 54.295 −19.161 −65.395 1.00 97.15 N ATOM 2544 CE1 HIS D 359 54.151 −17.835 −65.582 1.00 89.11 C ATOM 2545 NE2 HIS D 359 54.965 −17.463 −66.584 1.00 102.06 N ATOM 2546 CD2 HIS D 359 55.625 −18.553 −67.039 1.00 88.79 C ATOM 2547 C HIS D 359 55.275 −23.147 −67.731 1.00 40.22 C ATOM 2548 O HIS D 359 56.483 −23.111 −67.947 1.00 45.51 O ATOM 2549 N GLU D 360 54.528 −24.189 −68.063 1.00 27.08 N ATOM 2550 CA GLU D 360 55.139 −25.443 −68.521 1.00 27.32 C ATOM 2551 CB GLU D 360 54.210 −26.614 −68.172 1.00 31.37 C ATOM 2552 CG GLU D 360 54.595 −27.945 −68.805 1.00 34.63 C ATOM 2553 CD GLU D 360 55.817 −28.559 −68.147 1.00 41.93 C ATOM 2554 OE1 GLU D 360 56.415 −29.484 −68.736 1.00 39.25 O ATOM 2555 OE2 GLU D 360 56.182 −28.108 −67.044 1.00 38.61 O ATOM 2556 C GLU D 360 55.387 −25.420 −70.038 1.00 28.74 C ATOM 2557 O GLU D 360 56.405 −25.971 −70.541 1.00 24.80 O ATOM 2558 N THR D 361 54.424 −24.833 −70.757 1.00 23.58 N ATOM 2559 CA THR D 361 54.328 −24.964 −72.216 1.00 29.66 C ATOM 2560 CB THR D 361 52.956 −25.523 −72.644 1.00 36.08 C ATOM 2561 OG1 THR D 361 52.742 −26.789 −72.017 1.00 38.33 O ATOM 2562 CG2 THR D 361 52.893 −25.715 −74.156 1.00 33.81 C ATOM 2563 C THR D 361 54.520 −23.590 −72.853 1.00 30.62 C ATOM 2564 O THR D 361 53.910 −22.612 −72.429 1.00 29.15 O ATOM 2565 N LEU D 362 55.415 −23.514 −73.825 1.00 22.36 N ATOM 2566 CA LEU D 362 55.586 −22.312 −74.604 1.00 20.47 C ATOM 2567 CB LEU D 362 57.065 −22.186 −74.968 1.00 22.09 C ATOM 2568 CG LEU D 362 57.572 −20.894 −75.560 1.00 26.95 C ATOM 2569 CD1 LEU D 362 57.651 −19.787 −74.516 1.00 25.81 C ATOM 2570 CD2 LEU D 362 58.945 −21.158 −76.176 1.00 29.27 C ATOM 2571 C LEU D 362 54.712 −22.459 −75.859 1.00 21.04 C ATOM 2572 O LEU D 362 54.736 −23.506 −76.495 1.00 19.78 O ATOM 2573 N THR D 363 53.904 −21.447 −76.199 1.00 16.67 N ATOM 2574 CA THR D 363 53.126 −21.527 −77.450 1.00 15.97 C ATOM 2575 CB THR D 363 51.609 −21.246 −77.279 1.00 18.24 C ATOM 2576 OG1 THR D 363 51.420 −19.993 −76.625 1.00 16.20 O ATOM 2577 CG2 THR D 363 50.955 −22.366 −76.474 1.00 17.89 C ATOM 2578 C THR D 363 53.715 −20.596 −78.503 1.00 16.58 C ATOM 2579 O THR D 363 53.979 −19.417 −78.232 1.00 15.75 O ATOM 2580 N VAL D 364 53.996 −21.161 −79.670 1.00 13.70 N ATOM 2581 CA VAL D 364 54.587 −20.387 −80.772 1.00 16.04 C ATOM 2582 CB VAL D 364 56.089 −20.741 −80.988 1.00 15.95 C ATOM 2583 CG1 VAL D 364 56.897 −20.448 −79.721 1.00 15.03 C ATOM 2584 CG2 VAL D 364 56.270 −22.203 −81.384 1.00 14.84 C ATOM 2585 C VAL D 364 53.792 −20.600 −82.062 1.00 13.81 C ATOM 2586 O VAL D 364 53.202 −21.687 −82.287 1.00 12.28 O ATOM 2587 N TYR D 365 53.810 −19.579 −82.938 1.00 15.53 N ATOM 2588 CA TYR D 365 53.052 −19.662 −84.210 1.00 13.43 C ATOM 2589 CB TYR D 365 52.924 −18.280 −84.849 1.00 12.13 C ATOM 2590 CG TYR D 365 51.901 −17.385 −84.178 1.00 14.12 C ATOM 2591 CD1 TYR D 365 50.544 −17.768 −84.110 1.00 13.77 C ATOM 2592 CE1 TYR D 365 49.583 −16.926 −83.512 1.00 15.10 C ATOM 2593 CZ TYR D 365 49.991 −15.687 −82.984 1.00 15.49 C ATOM 2594 OH TYR D 365 49.053 −14.874 −82.375 1.00 17.24 O ATOM 2595 CE2 TYR D 365 51.329 −15.292 −83.029 1.00 15.81 C ATOM 2596 CD2 TYR D 365 52.285 −16.159 −83.623 1.00 14.04 C ATOM 2597 C TYR D 365 53.751 −20.598 −85.186 1.00 14.61 C ATOM 2598 O TYR D 365 53.100 −21.239 −86.010 1.00 15.23 O ATOM 2599 N LYS D 366 55.079 −20.683 −85.073 1.00 14.91 N ATOM 2600 CA LYS D 366 55.887 −21.352 −86.074 1.00 14.82 C ATOM 2601 CB LYS D 366 56.450 −20.314 −87.095 1.00 16.70 C ATOM 2602 CG LYS D 366 55.437 −19.735 −88.084 1.00 15.41 C ATOM 2603 CD LYS D 366 55.220 −20.782 −89.186 1.00 19.20 C ATOM 2604 CE LYS D 366 54.120 −20.437 −90.153 1.00 22.48 C ATOM 2605 NZ LYS D 366 54.054 −21.571 −91.138 1.00 15.78 N ATOM 2606 C LYS D 366 57.072 −22.039 −85.389 1.00 14.61 C ATOM 2607 O LYS D 366 57.672 −21.493 −84.455 1.00 16.82 O ATOM 2608 N ALA D 367 57.449 −23.187 −85.915 1.00 14.78 N ATOM 2609 CA ALA D 367 58.594 −23.932 −85.397 1.00 14.44 C ATOM 2610 CB ALA D 367 58.136 −24.894 −84.279 1.00 14.74 C ATOM 2611 C ALA D 367 59.243 −24.692 −86.554 1.00 16.81 C ATOM 2612 O ALA D 367 58.651 −24.822 −87.656 1.00 17.10 O ATOM 2613 N SER D 368 60.451 −25.187 −86.317 1.00 18.43 N ATOM 2614 CA SER D 368 61.260 −25.769 −87.382 1.00 20.30 C ATOM 2615 CB SER D 368 62.302 −24.752 −87.867 1.00 19.50 C ATOM 2616 OG SER D 368 63.108 −24.309 −86.799 1.00 23.02 O ATOM 2617 C SER D 368 61.964 −27.030 −86.888 1.00 16.89 C ATOM 2618 O SER D 368 62.204 −27.189 −85.663 1.00 19.11 O ATOM 2619 N ASN D 369 62.311 −27.915 −87.826 1.00 18.18 N ATOM 2620 CA ASN D 369 63.184 −29.042 −87.511 1.00 20.92 C ATOM 2621 CB ASN D 369 64.490 −28.539 −86.867 1.00 17.47 C ATOM 2622 CG ASN D 369 65.242 −27.569 −87.763 1.00 23.77 C ATOM 2623 OD1 ASN D 369 65.672 −26.505 −87.320 1.00 27.54 O ATOM 2624 ND2 ASN D 369 65.356 −27.914 −89.032 1.00 20.46 N ATOM 2625 C ASN D 369 62.512 −30.017 −86.559 1.00 24.80 C ATOM 2626 O ASN D 369 63.189 −30.723 −85.792 1.00 25.89 O ATOM 2627 N LEU D 370 61.186 −30.019 −86.578 1.00 22.54 N ATOM 2628 CA LEU D 370 60.407 −31.016 −85.867 1.00 23.88 C ATOM 2629 CB LEU D 370 59.256 −30.351 −85.073 1.00 21.84 C ATOM 2630 CG LEU D 370 59.675 −29.438 −83.921 1.00 20.70 C ATOM 2631 CD1 LEU D 370 58.484 −28.623 −83.428 1.00 17.93 C ATOM 2632 CD2 LEU D 370 60.274 −30.264 −82.780 1.00 20.54 C ATOM 2633 C LEU D 370 59.840 −32.012 −86.855 1.00 24.81 C ATOM 2634 O LEU D 370 59.453 −31.667 −87.978 1.00 25.01 O ATOM 2635 N ASN D 371 59.785 −33.254 −86.415 1.00 22.93 N ATOM 2636 CA ASN D 371 59.143 −34.298 −87.144 1.00 23.87 C ATOM 2637 CB ASN D 371 60.106 −35.481 −87.255 1.00 30.34 C ATOM 2638 CG ASN D 371 59.485 −36.667 −87.924 1.00 39.88 C ATOM 2639 OD1 ASN D 371 59.054 −36.593 −89.081 1.00 46.83 O ATOM 2640 ND2 ASN D 371 59.425 −37.774 −87.209 1.00 36.27 N ATOM 2641 C ASN D 371 57.855 −34.718 −86.400 1.00 22.49 C ATOM 2642 O ASN D 371 57.880 −34.907 −85.183 1.00 24.35 O ATOM 2643 N LEU D 372 56.753 −34.839 −87.141 1.00 21.33 N ATOM 2644 CA LEU D 372 55.467 −35.233 −86.584 1.00 25.52 C ATOM 2645 CB LEU D 372 54.321 −34.605 −87.391 1.00 25.63 C ATOM 2646 CG LEU D 372 54.361 −33.071 −87.496 1.00 24.98 C ATOM 2647 CD1 LEU D 372 53.250 −32.590 −88.396 1.00 24.11 C ATOM 2648 CD2 LEU D 372 54.244 −32.464 −86.106 1.00 22.99 C ATOM 2649 C LEU D 372 55.304 −36.742 −86.549 1.00 26.66 C ATOM 2650 O LEU D 372 55.524 −37.412 −87.548 1.00 26.61 O ATOM 2651 N ILE D 373 54.868 −37.253 −85.399 1.00 25.93 N ATOM 2652 CA ILE D 373 54.582 −38.667 −85.218 1.00 31.55 C ATOM 2653 CB ILE D 373 55.196 −39.172 −83.905 1.00 31.48 C ATOM 2654 CG1 ILE D 373 56.703 −38.984 −83.945 1.00 36.34 C ATOM 2655 CD1 ILE D 373 57.321 −39.470 −85.244 1.00 39.69 C ATOM 2656 CG2 ILE D 373 54.823 −40.638 −83.659 1.00 37.28 C ATOM 2657 C ILE D 373 53.086 −38.860 −85.125 1.00 33.17 C ATOM 2658 O ILE D 373 52.442 −38.242 −84.286 1.00 27.63 O ATOM 2659 N GLY D 374 52.529 −39.697 −85.993 1.00 36.46 N ATOM 2660 CA GLY D 374 51.115 −40.081 −85.880 1.00 39.38 C ATOM 2661 C GLY D 374 50.116 −39.071 −86.431 1.00 37.90 C ATOM 2662 O GLY D 374 50.466 −38.190 −87.226 1.00 35.72 O ATOM 2663 N ARG D 375 48.865 −39.212 −86.008 1.00 35.66 N ATOM 2664 CA ARG D 375 47.764 −38.390 −86.512 1.00 39.72 C ATOM 2665 CB ARG D 375 46.665 −39.284 −87.091 1.00 45.20 C ATOM 2666 CG ARG D 375 47.051 −39.986 −88.388 1.00 55.76 C ATOM 2667 CD ARG D 375 46.609 −41.445 −88.393 1.00 65.22 C ATOM 2668 NE ARG D 375 45.216 −41.611 −87.980 1.00 74.97 N ATOM 2669 CZ ARG D 375 44.167 −41.517 −88.797 1.00 81.23 C ATOM 2670 NH1 ARG D 375 44.340 −41.257 −90.087 1.00 79.15 N ATOM 2671 NH2 ARG D 375 42.940 −41.686 −88.321 1.00 79.81 N ATOM 2672 C ARG D 375 47.214 −37.543 −85.364 1.00 32.34 C ATOM 2673 O ARG D 375 47.450 −37.866 −84.186 1.00 31.73 O ATOM 2674 N PRO D 376 46.499 −36.441 −85.681 1.00 32.50 N ATOM 2675 CA PRO D 376 46.017 −35.605 −84.555 1.00 27.40 C ATOM 2676 CB PRO D 376 45.261 −34.473 −85.262 1.00 32.97 C ATOM 2677 CG PRO D 376 45.906 −34.376 −86.609 1.00 36.81 C ATOM 2678 CD PRO D 376 46.307 −35.780 −86.987 1.00 32.39 C ATOM 2679 C PRO D 376 45.067 −36.363 −83.616 1.00 27.51 C ATOM 2680 O PRO D 376 44.326 −37.224 −84.056 1.00 32.39 O ATOM 2681 N SER D 377 45.073 −36.012 −82.342 1.00 22.19 N ATOM 2682 CA SER D 377 44.061 −36.492 −81.432 1.00 24.19 C ATOM 2683 CB SER D 377 44.642 −37.593 −80.518 1.00 26.97 C ATOM 2684 OG SER D 377 43.698 −37.944 −79.521 1.00 26.58 O ATOM 2685 C SER D 377 43.550 −35.351 −80.584 1.00 23.68 C ATOM 2686 O SER D 377 44.317 −34.441 −80.234 1.00 21.53 O ATOM 2687 N THR D 378 42.271 −35.410 −80.204 1.00 19.26 N ATOM 2688 CA THR D 378 41.705 −34.397 −79.301 1.00 21.51 C ATOM 2689 CB THR D 378 40.257 −34.006 −79.692 1.00 28.98 C ATOM 2690 OG1 THR D 378 39.474 −35.186 −79.785 1.00 28.60 O ATOM 2691 CG2 THR D 378 40.229 −33.298 −81.059 1.00 26.30 C ATOM 2692 C THR D 378 41.677 −34.886 −77.859 1.00 22.90 C ATOM 2693 O THR D 378 41.363 −34.119 −76.957 1.00 22.50 O ATOM 2694 N VAL D 379 42.011 −36.162 −77.651 1.00 24.01 N ATOM 2695 CA VAL D 379 41.910 −36.763 −76.315 1.00 24.88 C ATOM 2696 CB VAL D 379 42.232 −38.282 −76.366 1.00 26.77 C ATOM 2697 CG1 VAL D 379 41.924 −38.929 −75.020 1.00 30.28 C ATOM 2698 CG2 VAL D 379 41.420 −38.961 −77.483 1.00 30.55 C ATOM 2699 C VAL D 379 42.851 −36.059 −75.345 1.00 21.36 C ATOM 2700 O VAL D 379 44.052 −35.946 −75.619 1.00 23.03 O ATOM 2701 N HIS D 380 42.302 −35.601 −74.209 1.00 20.07 N ATOM 2702 CA HIS D 380 43.053 −34.884 −73.156 1.00 23.59 C ATOM 2703 CB HIS D 380 44.130 −35.769 −72.478 1.00 21.22 C ATOM 2704 CG HIS D 380 43.659 −37.163 −72.110 1.00 29.25 C ATOM 2705 ND1 HIS D 380 42.624 −37.386 −71.282 1.00 33.10 N ATOM 2706 CE1 HIS D 380 42.449 −38.713 −71.121 1.00 26.61 C ATOM 2707 NE2 HIS D 380 43.397 −39.345 −71.822 1.00 30.44 N ATOM 2708 CD2 HIS D 380 44.165 −38.421 −72.451 1.00 32.96 C ATOM 2709 C HIS D 380 43.735 −33.611 −73.629 1.00 26.08 C ATOM 2710 O HIS D 380 44.682 −33.152 −72.989 1.00 20.61 O ATOM 2711 N SER D 381 43.255 −33.006 −74.715 1.00 24.43 N ATOM 2712 CA SER D 381 43.917 −31.802 −75.216 1.00 21.29 C ATOM 2713 CB SER D 381 43.274 −31.290 −76.505 1.00 24.58 C ATOM 2714 OG SER D 381 43.976 −30.118 −76.959 1.00 24.41 O ATOM 2715 C SER D 381 44.030 −30.671 −74.168 1.00 18.56 C ATOM 2716 O SER D 381 43.038 −30.283 −73.513 1.00 20.72 O ATOM 2717 N TRP D 382 45.217 −30.099 −74.056 1.00 16.61 N ATOM 2718 CA TRP D 382 45.439 −28.979 −73.139 1.00 18.86 C ATOM 2719 CB TRP D 382 46.919 −28.831 −72.790 1.00 24.08 C ATOM 2720 CG TRP D 382 47.498 −30.064 −72.142 1.00 25.00 C ATOM 2721 CD1 TRP D 382 46.837 −30.979 −71.308 1.00 23.24 C ATOM 2722 NE1 TRP D 382 47.710 −31.991 −70.905 1.00 25.16 N ATOM 2723 CE2 TRP D 382 48.949 −31.776 −71.436 1.00 21.93 C ATOM 2724 CD2 TRP D 382 48.873 −30.544 −72.241 1.00 24.42 C ATOM 2725 CE3 TRP D 382 50.019 −30.085 −72.877 1.00 26.05 C ATOM 2726 CZ3 TRP D 382 51.203 −30.831 −72.751 1.00 27.58 C ATOM 2727 CH2 TRP D 382 51.251 −32.016 −71.983 1.00 29.29 C ATOM 2728 CZ2 TRP D 382 50.130 −32.499 −71.305 1.00 26.50 C ATOM 2729 C TRP D 382 44.919 −27.670 −73.671 1.00 23.15 C ATOM 2730 O TRP D 382 44.885 −26.667 −72.945 1.00 22.81 O ATOM 2731 N PHE D 383 44.539 −27.664 −74.947 1.00 18.80 N ATOM 2732 CA PHE D 383 43.985 −26.458 −75.590 1.00 21.89 C ATOM 2733 CB PHE D 383 45.002 −25.888 −76.601 1.00 18.94 C ATOM 2734 CG PHE D 383 46.294 −25.453 −75.965 1.00 18.29 C ATOM 2735 CD1 PHE D 383 46.383 −24.232 −75.291 1.00 21.99 C ATOM 2736 CE1 PHE D 383 47.582 −23.829 −74.679 1.00 23.29 C ATOM 2737 CZ PHE D 383 48.711 −24.643 −74.756 1.00 22.42 C ATOM 2738 CE2 PHE D 383 48.626 −25.872 −75.404 1.00 21.97 C ATOM 2739 CD2 PHE D 383 47.431 −26.272 −76.016 1.00 18.10 C ATOM 2740 C PHE D 383 42.659 −26.807 −76.253 1.00 20.33 C ATOM 2741 O PHE D 383 42.621 −27.267 −77.379 1.00 19.52 O ATOM 2742 N PRO D 384 41.551 −26.655 −75.506 1.00 24.45 N ATOM 2743 CA PRO D 384 40.237 −27.104 −75.968 1.00 25.86 C ATOM 2744 CB PRO D 384 39.286 −26.541 −74.890 1.00 33.13 C ATOM 2745 CG PRO D 384 40.137 −26.480 −73.659 1.00 36.86 C ATOM 2746 CD PRO D 384 41.486 −26.036 −74.165 1.00 27.74 C ATOM 2747 C PRO D 384 39.919 −26.472 −77.318 1.00 23.10 C ATOM 2748 O PRO D 384 40.217 −25.298 −77.526 1.00 26.74 O ATOM 2749 N GLY D 385 39.410 −27.273 −78.247 1.00 23.86 N ATOM 2750 CA GLY D 385 39.190 −26.821 −79.618 1.00 20.87 C ATOM 2751 C GLY D 385 40.309 −27.189 −80.557 1.00 19.55 C ATOM 2752 O GLY D 385 40.168 −27.041 −81.755 1.00 23.34 O ATOM 2753 N TYR D 386 41.445 −27.660 −80.007 1.00 20.31 N ATOM 2754 CA TYR D 386 42.586 −28.134 −80.827 1.00 18.04 C ATOM 2755 CB TYR D 386 43.843 −27.348 −80.493 1.00 17.22 C ATOM 2756 CG TYR D 336 43.759 −25.886 −80.888 1.00 16.50 C ATOM 2757 CD2 TYR D 386 44.173 −25.472 −82.140 1.00 18.88 C ATOM 2758 CE2 TYR D 386 44.097 −24.121 −82.519 1.00 16.81 C ATOM 2759 CZ TYR D 386 43.602 −23.181 −81.629 1.00 17.04 C ATOM 2760 OH TYR D 386 43.526 −21.837 −82.018 1.00 19.56 O ATOM 2761 CE1 TYR D 386 43.177 −23.560 −80.360 1.00 17.79 C ATOM 2762 CD1 TYR D 386 43.258 −24.924 −79.994 1.00 18.35 C ATOM 2763 C TYR D 386 42.879 −29.605 −80.586 1.00 19.53 C ATOM 2764 O TYR D 336 42.698 −30.105 −79.467 1.00 19.82 O ATOM 2765 N ALA D 387 43.329 −30.275 −81.638 1.00 17.74 N ATOM 2766 CA ALA D 387 43.877 −31.632 −81.562 1.00 20.43 C ATOM 2767 CB ALA D 387 43.397 −32.442 −82.745 1.00 16.82 C ATOM 2768 C ALA D 387 45.411 −31.545 −81.553 1.00 20.36 C ATOM 2769 O ALA D 387 45.972 −30.549 −82.006 1.00 19.86 O ATOM 2770 N TRP D 388 46.089 −32.553 −80.987 1.00 19.70 N ATOM 2771 CA TRP D 388 47.558 −32.524 −80.886 1.00 18.19 C ATOM 2772 CB TRP D 338 48.022 −32.599 −79.426 1.00 20.16 C ATOM 2773 CG TRP D 388 47.357 −33.718 −78.650 1.00 21.18 C ATOM 2774 CD1 TRP D 388 46.235 −33.626 −77.857 1.00 19.17 C ATOM 2775 NE1 TRP D 388 45.919 −34.867 −77.309 1.00 25.77 N ATOM 2776 CE2 TRP D 388 46.779 −35.812 −77.737 1.00 22.02 C ATOM 2777 CD2 TRP D 388 47.747 −35.148 −78.605 1.00 24.52 C ATOM 2778 CE3 TRP D 388 48.791 −35.900 −79.155 1.00 22.55 C ATOM 2779 CZ3 TRP D 388 48.853 −37.280 −78.861 1.00 27.56 C ATOM 2780 CH2 TRP D 388 47.892 −37.896 −78.021 1.00 27.40 C ATOM 2781 CZ2 TRP D 388 46.854 −37.172 −77.440 1.00 22.96 C ATOM 2782 C TRP D 388 48.157 −33.648 −81.660 1.00 19.88 C ATOM 2783 O TRP D 388 47.525 −34.699 −81.836 1.00 20.05 O ATOM 2784 N THR D 389 49.362 −33.410 −82.183 1.00 20.25 N ATOM 2785 CA THR D 389 50.188 −34.437 −82.821 1.00 20.61 C ATOM 2786 CB THR D 389 50.304 −34.183 −84.353 1.00 23.30 C ATOM 2787 OG1 THR D 389 48.991 −34.110 −84.950 1.00 21.65 O ATOM 2788 CG2 THR D 389 51.111 −35.320 −85.052 1.00 25.38 C ATOM 2789 C THR D 389 51.593 −34.333 −82.175 1.00 20.88 C ATOM 2790 O THR D 389 52.158 −33.256 −82.098 1.00 19.77 O ATOM 2791 N ILE D 390 52.169 −35.457 −81.730 1.00 20.43 N ATOM 2792 CA ILE D 390 53.483 −35.413 −81.073 1.00 18.66 C ATOM 2793 CB ILE D 390 53.935 −36.817 −80.566 1.00 21.69 C ATOM 2794 CG1 ILE D 390 53.078 −37.251 −79.366 1.00 22.22 C ATOM 2795 CD1 ILE D 390 53.070 −38.773 −79.188 1.00 27.82 C ATOM 2796 CG2 ILE D 390 55.384 −36.795 −80.141 1.00 22.82 C ATOM 2797 C ILE D 390 54.539 −34.885 −82.038 1.00 17.90 C ATOM 2798 O ILE D 390 54.549 −35.256 −83.228 1.00 18.74 O ATOM 2799 N ALA D 391 55.399 −34.010 −81.524 1.00 16.82 N ATOM 2800 CA ALA D 391 56.467 −33.386 −82.327 1.00 20.59 C ATOM 2801 CB ALA D 391 56.221 −31.865 −82.438 1.00 20.63 C ATOM 2802 C ALA D 391 57.838 −33.662 −81.698 1.00 20.11 C ATOM 2803 O ALA D 391 58.111 −33.250 −80.557 1.00 21.13 O ATOM 2804 N GLN D 392 58.713 −34.337 −82.456 1.00 20.43 N ATOM 2805 CA GLN D 392 60.048 −34.667 −81.977 1.00 22.86 C ATOM 2806 CB GLN D 392 60.292 −36.192 −82.076 1.00 21.97 C ATOM 2807 CG GLN D 392 60.155 −36.738 −83.484 1.00 27.05 C ATOM 2808 CD GLN D 392 60.535 −38.210 −83.597 1.00 36.97 C ATOM 2809 OE1 GLN D 392 61.045 −38.815 −82.651 1.00 35.40 O ATOM 2810 NE2 GLN D 392 60.276 −38.787 −84.747 1.00 32.21 N ATOM 2811 C GLN D 392 61.098 −33.931 −82.796 1.00 19.30 C ATOM 2812 O GLN D 392 60.871 −33.620 −83.945 1.00 20.51 O ATOM 2813 N CYS D 393 62.251 −33.679 −82.180 1.00 19.60 N ATOM 2814 CA CYS D 393 63.410 −33.116 −82.863 1.00 24.38 C ATOM 2815 CB CYS D 393 64.582 −32.989 −81.879 1.00 21.32 C ATOM 2816 SG CYS D 393 66.117 −32.301 −82.593 1.00 22.90 S ATOM 2817 C CYS D 393 63.781 −34.059 −84.013 1.00 23.15 C ATOM 2818 O CYS D 393 63.925 −35.248 −83.802 1.00 25.53 O ATOM 2819 N LYS D 394 63.911 −33.534 −85.220 1.00 20.51 N ATOM 2820 CA LYS D 394 64.245 −34.399 −86.356 1.00 26.63 C ATOM 2821 CB LYS D 394 64.053 −33.679 −87.690 1.00 22.99 C ATOM 2822 CG LYS D 394 65.219 −32.758 −88.057 1.00 26.05 C ATOM 2823 CD LYS D 394 64.929 −31.954 −89.321 1.00 32.45 C ATOM 2824 CE LYS D 394 66.165 −31.181 −89.765 1.00 34.37 C ATOM 2825 NZ LYS D 394 65.814 −30.211 −90.828 1.00 32.51 N ATOM 2826 C LYS D 394 65.687 −34.947 −86.247 1.00 24.31 C ATOM 2827 O LYS D 394 66.012 −35.965 −86.880 1.00 27.33 O ATOM 2828 N ILE D 395 66.535 −34.250 −85.481 1.00 22.07 N ATOM 2829 CA ILE D 395 67.954 −34.646 −85.329 1.00 30.16 C ATOM 2830 CB ILE D 395 68.880 −33.463 −84.944 1.00 32.13 C ATOM 2831 CG1 ILE D 395 69.018 −32.449 −86.096 1.00 32.56 C ATOM 2832 CD1 ILE D 395 69.165 −33.047 −87.473 1.00 33.80 C ATOM 2833 CG2 ILE D 395 70.263 −33.958 −84.490 1.00 30.13 C ATOM 2834 C ILE D 395 68.117 −35.777 −84.310 1.00 32.39 C ATOM 2835 O ILE D 395 68.687 −36.812 −84.618 1.00 31.83 O ATOM 2836 N CYS D 396 67.591 −35.580 −83.111 1.00 22.91 N ATOM 2837 CA CYS D 396 67.875 −36.486 −81.989 1.00 24.90 C ATOM 2838 CB CYS D 396 68.540 −35.710 −80.849 1.00 26.29 C ATOM 2839 SG CYS D 396 67.392 −34.667 −79.902 1.00 26.29 S ATOM 2840 C CYS D 396 66.639 −37.254 −81.475 1.00 26.23 C ATOM 2841 O CYS D 396 66.746 −38.040 −80.534 1.00 29.29 O ATOM 2842 N ALA D 397 65.470 −36.992 −82.071 1.00 22.61 N ATOM 2843 CA ALA D 397 64.201 −37.677 −81.709 1.00 25.29 C ATOM 2844 CB ALA D 397 64.328 −39.203 −81.848 1.00 25.44 C ATOM 2845 C ALA D 397 63.662 −37.305 −80.330 1.00 25.97 C ATOM 2846 O ALA D 397 62.674 −37.871 −79.882 1.00 25.29 O ATOM 2847 N SER D 398 64.281 −36.329 −79.678 1.00 20.06 N ATOM 2848 CA SER D 398 63.770 −35.863 −78.387 1.00 25.85 C ATOM 2849 CB SER D 398 64.682 −34.776 −77.817 1.00 26.83 C ATOM 2850 OG SER D 398 64.119 −34.158 −76.673 1.00 43.29 O ATOM 2851 C SER D 398 62.339 −35.335 −78.569 1.00 24.41 C ATOM 2852 O SER D 398 62.070 −34.595 −79.514 1.00 22.42 O ATOM 2853 N HIS D 399 61.411 −35.796 −77.725 1.00 22.73 N ATOM 2854 CA HIS D 399 60.027 −35.284 −77.746 1.00 25.25 C ATOM 2855 CB HIS D 399 59.090 −36.183 −76.938 1.00 25.16 C ATOM 2856 CG HIS D 399 58.789 −37.515 −77.592 1.00 29.41 C ATOM 2857 ND1 HIS D 399 59.657 −38.141 −78.423 1.00 42.10 N ATOM 2858 CE1 HIS D 399 59.126 −39.316 −78.823 1.00 32.43 C ATOM 2859 NE2 HIS D 399 57.922 −39.447 −78.249 1.00 38.99 N ATOM 2860 CD2 HIS D 399 57.685 −38.364 −77.473 1.00 30.44 C ATOM 2861 C HIS D 399 59.979 −33.866 −77.218 1.00 26.07 C ATOM 2862 O HIS D 399 60.175 −33.624 −76.026 1.00 26.52 O ATOM 2863 N ILE D 400 59.700 −32.912 −78.101 1.00 18.90 N ATOM 2864 CA ILE D 400 59.814 −31.492 −77.755 1.00 21.18 C ATOM 2865 CB ILE D 400 60.427 −30.671 −78.916 1.00 22.02 C ATOM 2866 CG1 ILE D 400 61.814 −31.213 −79.280 1.00 26.01 C ATOM 2867 CD1 ILE D 400 62.851 −30.915 −78.247 1.00 24.92 C ATOM 2868 CG2 ILE D 400 60.554 −29.183 −78.541 1.00 20.07 C ATOM 2869 C ILE D 400 58.462 −30.880 −77.394 1.00 19.50 C ATOM 2870 O ILE D 400 58.392 −29.961 −76.573 1.00 22.64 O ATOM 2871 N GLY D 401 57.412 −31.381 −78.019 1.00 20.88 N ATOM 2872 CA GLY D 401 56.065 −30.843 −77.787 1.00 20.61 C ATOM 2873 C GLY D 401 55.094 −31.405 −78.756 1.00 21.00 C ATOM 2874 O GLY D 401 55.157 −32.587 −79.080 1.00 20.04 O ATOM 2875 N TRP D 402 54.159 −30.558 −79.212 1.00 18.09 N ATOM 2876 CA TRP D 402 53.078 −30.991 −80.069 1.00 17.38 C ATOM 2877 CB TRP D 402 51.787 −31.276 −79.257 1.00 16.14 C ATOM 2878 CG TRP D 402 52.008 −32.297 −78.200 1.00 18.15 C ATOM 2879 CD1 TRP D 402 51.756 −33.677 −78.286 1.00 19.91 C ATOM 2880 NE1 TRP D 402 52.167 −34.313 −77.129 1.00 19.11 N ATOM 2881 CE2 TRP D 402 52.717 −33.402 −76.263 1.00 20.02 C ATOM 2882 CD2 TRP D 402 52.678 −32.095 −76.923 1.00 17.68 C ATOM 2883 CE3 TRP D 402 53.191 −30.991 −76.260 1.00 19.50 C ATOM 2884 CZ3 TRP D 402 53.745 −31.174 −74.980 1.00 23.62 C ATOM 2885 CH2 TRP D 402 53.787 −32.446 −74.374 1.00 23.72 C ATOM 2886 CZ2 TRP D 402 53.261 −33.573 −75.000 1.00 21.22 C ATOM 2887 C TRP D 402 52.747 −29.932 −81.048 1.00 16.27 C ATOM 2888 O TRP D 402 52.825 −28.729 −80.732 1.00 16.67 O ATOM 2889 N LYS D 403 52.282 −30.354 −82.200 1.00 17.19 N ATOM 2890 CA LYS D 403 51.580 −29.444 −83.110 1.00 18.61 C ATOM 2891 CB LYS D 403 51.747 −29.906 −84.534 1.00 19.86 C ATOM 2892 CG LYS D 403 51.145 −28.943 −85.534 1.00 22.36 C ATOM 2893 CD LYS D 403 51.345 −29.462 −86.962 1.00 23.16 C ATOM 2894 CE LYS D 403 51.176 −28.334 −87.968 1.00 30.55 C ATOM 2895 NZ LYS D 403 51.137 −28.881 −89.362 1.00 43.90 N ATOM 2896 C LYS D 403 50.107 −29.450 −82.767 1.00 18.59 C ATOM 2897 O LYS D 403 49.512 −30.511 −82.660 1.00 19.04 O ATOM 2898 N PHE D 404 49.518 −28.263 −82.583 1.00 15.85 N ATOM 2899 CA PHE D 404 48.099 −28.178 −82.265 1.00 15.88 C ATOM 2900 CB PHE D 404 47.846 −27.268 −81.039 1.00 15.01 C ATOM 2901 CG PHE D 404 48.173 −27.943 −79.722 1.00 14.42 C ATOM 2902 CD1 PHE D 404 47.250 −28.799 −79.119 1.00 17.09 C ATOM 2903 CE1 PHE D 404 47.550 −29.454 −77.920 1.00 16.70 C ATOM 2904 CZ PHE D 404 48.807 −29.283 −77.345 1.00 16.21 C ATOM 2905 CE2 PHE D 404 49.760 −28.466 −77.962 1.00 15.82 C ATOM 2906 CD2 PHE D 404 49.438 −27.801 −79.151 1.00 15.87 C ATOM 2907 C PHE D 404 47.365 −27.655 −83.486 1.00 18.10 C ATOM 2908 O PHE D 404 47.786 −26.652 −84.082 1.00 18.76 O ATOM 2909 N THR D 405 46.293 −28.346 −83.872 1.00 17.48 N ATOM 2910 CA THR D 405 45.537 −27.995 −85.077 1.00 19.83 C ATOM 2911 CB THR D 405 45.701 −29.076 −86.157 1.00 22.66 C ATOM 2912 OG1 THR D 405 45.506 −30.366 −85.553 1.00 23.05 O ATOM 2913 CG2 THR D 405 47.127 −29.010 −86.766 1.00 22.52 C ATOM 2914 C THR D 405 44.053 −27.823 −84.734 1.00 20.90 C ATOM 2915 O THR D 405 43.482 −28.622 −83.984 1.00 19.38 O ATOM 2916 N ALA D 406 43.451 −26.742 −85.251 1.00 18.26 N ATOM 2917 CA ALA D 406 42.106 −26.340 −84.864 1.00 18.56 C ATOM 2918 CB ALA D 406 41.778 −24.955 −85.466 1.00 19.38 C ATOM 2919 C ALA D 406 41.106 −27.376 −85.353 1.00 18.61 C ATOM 2920 O ALA D 406 41.244 −27.899 −86.457 1.00 23.36 O ATOM 2921 N THR D 407 40.098 −27.667 −84.542 1.00 21.85 N ATOM 2922 CA THR D 407 39.047 −28.594 −84.974 1.00 22.97 C ATOM 2923 CB THR D 407 38.429 −29.381 −83.786 1.00 21.80 C ATOM 2924 OG1 THR D 407 37.845 −28.469 −82.849 1.00 25.70 O ATOM 2925 CG2 THR D 407 39.519 −30.175 −83.051 1.00 22.40 C ATOM 2926 C THR D 407 37.948 −27.853 −85.776 1.00 32.49 C ATOM 2927 O THR D 407 37.209 −28.480 −86.492 1.00 30.54 O ATOM 2928 N LYS D 408 37.880 −26.513 −85.654 1.00 25.87 N ATOM 2929 CA LYS D 408 36.832 −25.701 −86.364 1.00 28.10 C ATOM 2930 CB LYS D 408 35.870 −25.048 −85.355 1.00 32.89 C ATOM 2931 CG LYS D 408 34.970 −25.994 −84.585 1.00 36.35 C ATOM 2932 CD LYS D 408 34.202 −25.257 −83.497 1.00 48.16 C ATOM 2933 CE LYS D 408 32.762 −24.959 −83.914 1.00 63.50 C ATOM 2934 NZ LYS D 408 32.634 −23.746 −84.770 1.00 52.08 N ATOM 2935 C LYS D 408 37.522 −24.588 −87.181 1.00 30.24 C ATOM 2936 O LYS D 408 38.502 −24.005 −86.728 1.00 22.47 O ATOM 2937 N LYS D 409 36.963 −24.258 −88.338 1.00 26.45 N ATOM 2938 CA LYS D 409 37.560 −23.270 −89.245 1.00 26.90 C ATOM 2939 CB LYS D 409 36.853 −23.310 −90.605 1.00 37.47 C ATOM 2940 CG LYS D 409 36.642 −24.707 −91.166 1.00 56.31 C ATOM 2941 CD LYS D 409 37.459 −24.950 −92.422 1.00 62.22 C ATOM 2942 CE LYS D 409 36.731 −25.917 −93.350 1.00 70.53 C ATOM 2943 NZ LYS D 409 37.416 −26.054 −94.662 1.00 75.31 N ATOM 2944 C LYS D 409 37.509 −21.828 −88.696 1.00 24.58 C ATOM 2945 O LYS D 409 38.265 −20.966 −89.135 1.00 28.14 O ATOM 2946 N ASP D 410 36.628 −21.570 −87.748 1.00 28.01 N ATOM 2947 CA ASP D 410 36.371 −20.172 −87.340 1.00 36.30 C ATOM 2948 CB ASP D 410 34.898 −19.976 −86.963 1.00 39.17 C ATOM 2949 CG ASP D 410 34.518 −20.716 −85.688 1.00 55.66 C ATOM 2950 OD1 ASP D 410 35.157 −21.754 −85.375 1.00 51.51 O ATOM 2951 OD2 ASP D 410 33.593 −20.249 −84.988 1.00 61.91 O ATOM 2952 C ASP D 410 37.306 −19.706 −86.202 1.00 36.47 C ATOM 2953 O ASP D 410 37.162 −18.592 −85.685 1.00 39.80 O ATOM 2954 N MET D 411 38.252 −20.579 −85.824 1.00 31.09 N ATOM 2955 CA MET D 411 39.228 −20.315 −84.748 1.00 27.12 C ATOM 2956 CB MET D 411 39.606 −21.648 −84.053 1.00 20.71 C ATOM 2957 CG MET D 411 38.462 −22.248 −83.261 1.00 33.06 C ATOM 2958 SD MET D 411 38.885 −23.835 −82.490 1.00 38.53 S ATOM 2959 CE MET D 411 38.689 −25.017 −83.757 1.00 31.10 C ATOM 2960 C MET D 411 40.504 −19.665 −85.302 1.00 20.43 C ATOM 2961 O MET D 411 40.856 −19.867 −86.470 1.00 20.88 O ATOM 2962 N SER D 412 41.224 −18.927 −84.452 1.00 20.52 N ATOM 2963 CA SER D 412 42.574 −18.472 −84.801 1.00 19.80 C ATOM 2964 CB SER D 412 42.598 −16.993 −85.229 1.00 20.35 C ATOM 2965 OG SER D 412 42.148 −16.141 −84.152 1.00 23.08 O ATOM 2966 C SER D 412 43.485 −18.768 −83.605 1.00 19.45 C ATOM 2967 O SER D 412 43.076 −18.495 −82.454 1.00 17.91 O ATOM 2968 N PRO D 413 44.788 −18.912 −83.876 1.00 16.20 N ATOM 2969 CA PRO D 413 45.291 −19.597 −85.050 1.00 16.92 C ATOM 2970 CB PRO D 413 46.813 −19.674 −84.771 1.00 14.98 C ATOM 2971 CG PRO D 413 46.867 −19.942 −83.312 1.00 16.17 C ATOM 2972 CD PRO D 413 45.665 −19.185 −82.703 1.00 15.30 C ATOM 2973 C PRO D 413 44.695 −20.960 −85.366 1.00 16.13 C ATOM 2974 O PRO D 413 44.231 −21.667 −84.470 1.00 17.90 O ATOM 2975 N GLN D 414 44.681 −21.305 −86.648 1.00 15.27 N ATOM 2976 CA GLN D 414 44.269 −22.633 −87.052 1.00 15.54 C ATOM 2977 CB GLN D 414 44.021 −22.669 −88.553 1.00 18.13 C ATOM 2978 CG GLN D 414 42.676 −22.057 −88.954 1.00 19.04 C ATOM 2979 CD GLN D 414 41.508 −22.881 −88.469 1.00 18.67 C ATOM 2980 OE1 GLN D 414 40.749 −22.474 −87.590 1.00 24.03 O ATOM 2981 NE2 GLN D 414 41.388 −24.058 −89.000 1.00 14.78 N ATOM 2982 C GLN D 414 45.316 −23.707 −86.658 1.00 18.36 C ATOM 2983 O GLN D 414 45.002 −24.892 −86.593 1.00 19.98 O ATOM 2984 N LYS D 415 46.549 −23.284 −86.423 1.00 15.11 N ATOM 2985 CA LYS D 415 47.615 −24.200 −85.961 1.00 18.74 C ATOM 2986 CB LYS D 415 48.321 −24.936 −87.143 1.00 24.21 C ATOM 2987 CG LYS D 415 49.397 −24.109 −87.835 1.00 37.45 C ATOM 2988 CD LYS D 415 49.753 −24.667 −89.199 1.00 42.17 C ATOM 2989 CE LYS D 415 50.241 −23.566 −90.120 1.00 35.40 C ATOM 2990 NZ LYS D 415 49.120 −22.642 −90.526 1.00 39.35 N ATOM 2991 C LYS D 415 48.613 −23.440 −85.157 1.00 17.77 C ATOM 2992 O LYS D 415 48.801 −22.237 −85.359 1.00 16.36 O ATOM 2993 N PHE D 416 49.265 −24.137 −84.224 1.00 15.39 N ATOM 2994 CA PHE D 416 50.367 −23.587 −83.499 1.00 13.97 C ATOM 2995 CB PHE D 416 49.906 −22.538 −82.432 1.00 13.98 C ATOM 2996 CG PHE D 416 49.113 −23.119 −81.306 1.00 13.20 C ATOM 2997 CD2 PHE D 416 49.755 −23.504 −80.123 1.00 15.38 C ATOM 2998 CE2 PHE D 416 49.029 −24.072 −79.075 1.00 16.53 C ATOM 2999 CZ PHE D 416 47.651 −24.254 −79.196 1.00 17.32 C ATOM 3000 CE1 PHE D 416 46.995 −23.893 −80.375 1.00 16.12 C ATOM 3001 CD1 PHE D 416 47.726 −23.325 −81.425 1.00 16.37 C ATOM 3002 C PHE D 416 51.126 −24.759 −82.862 1.00 14.27 C ATOM 3003 O PHE D 416 50.735 −25.902 −83.039 1.00 15.95 O ATOM 3004 N TRP D 417 52.236 −24.445 −82.197 1.00 15.15 N ATOM 3005 CA TRP D 417 53.061 −25.453 −81.512 1.00 15.27 C ATOM 3006 CB TRP D 417 54.498 −25.364 −82.024 1.00 15.46 C ATOM 3007 CG TRP D 417 54.574 −25.549 −83.513 1.00 17.45 C ATOM 3008 CD1 TRP D 417 54.397 −24.560 −84.514 1.00 17.65 C ATOM 3009 NE1 TRP D 417 54.476 −25.121 −85.765 1.00 17.37 N ATOM 3010 CE2 TRP D 417 54.723 −26.465 −85.671 1.00 21.95 C ATOM 3011 CD2 TRP D 417 54.770 −26.803 −84.239 1.00 18.57 C ATOM 3012 CE3 TRP D 417 55.027 −28.135 −83.857 1.00 19.07 C ATOM 3013 CZ3 TRP D 417 55.203 −29.102 −84.867 1.00 20.47 C ATOM 3014 CH2 TRP D 417 55.174 −28.749 −86.247 1.00 18.03 C ATOM 3015 CZ2 TRP D 417 54.903 −27.429 −86.669 1.00 19.17 C ATOM 3016 C TRP D 417 53.036 −25.216 −80.048 1.00 17.19 C ATOM 3017 O TRP D 417 53.240 −24.089 −79.583 1.00 17.21 O ATOM 3018 N GLY D 418 52.828 −26.281 −79.288 1.00 15.50 N ATOM 3019 CA GLY D 418 52.968 −26.191 −77.839 1.00 17.14 C ATOM 3020 C GLY D 418 54.210 −26.945 −77.460 1.00 20.96 C ATOM 3021 O GLY D 418 54.272 −28.139 −77.645 1.00 18.76 O ATOM 3022 N LEU D 419 55.205 −26.232 −76.952 1.00 17.38 N ATOM 3023 CA LEU D 419 56.532 −26.826 −76.722 1.00 17.67 C ATOM 3024 CB LEU D 419 57.605 −26.031 −77.436 1.00 17.99 C ATOM 3025 CG LEU D 419 57.414 −25.837 −78.932 1.00 21.22 C ATOM 3026 CD1 LEU D 419 58.557 −25.003 −79.458 1.00 21.28 C ATOM 3027 CD2 LEU D 419 57.297 −27.193 −79.664 1.00 16.10 C ATOM 3028 C LEU D 419 56.855 −26.865 −75.240 1.00 20.53 C ATOM 3029 O LEU D 419 56.672 −25.866 −74.509 1.00 21.57 O ATOM 3030 N THR D 420 57.386 −28.000 −74.793 1.00 20.09 N ATOM 3031 CA THR D 420 57.776 −28.125 −73.392 1.00 19.54 C ATOM 3032 CB THR D 420 58.056 −29.600 −73.053 1.00 20.93 C ATOM 3033 OG1 THR D 420 56.896 −30.364 −73.371 1.00 21.41 O ATOM 3034 CG2 THR D 420 58.401 −29.767 −71.565 1.00 18.81 C ATOM 3035 C THR D 420 59.013 −27.292 −73.140 1.00 19.42 C ATOM 3036 O THR D 420 60.060 −27.543 −73.742 1.00 21.87 O ATOM 3037 N ARG D 421 58.891 −26.287 −72.256 1.00 19.64 N ATOM 3038 CA ARG D 421 59.970 −25.320 −72.011 1.00 22.01 C ATOM 3039 CB ARG D 421 59.574 −24.319 −70.937 1.00 28.17 C ATOM 3040 CG ARG D 421 58.809 −23.137 −71.455 1.00 42.45 C ATOM 3041 CD ARG D 421 58.322 −22.288 −70.303 1.00 48.21 C ATOM 3042 NE ARG D 421 57.077 −21.627 −70.645 1.00 49.13 N ATOM 3043 CZ ARG D 421 56.950 −20.317 −70.792 1.00 57.75 C ATOM 3044 NH1 ARG D 421 57.994 −19.527 −70.595 1.00 48.98 N ATOM 3045 NH2 ARG D 421 55.772 −19.795 −71.111 1.00 56.93 N ATOM 3046 C ARG D 421 61.246 −26.010 −71.583 1.00 22.68 C ATOM 3047 O ARG D 421 62.319 −25.613 −71.996 1.00 24.46 O ATOM 3048 N SER D 422 61.110 −27.049 −70.752 1.00 25.59 N ATOM 3049 CA SER D 422 62.278 −27.791 −70.229 1.00 26.45 C ATOM 3050 CB SER D 422 61.864 −28.719 −69.063 1.00 23.58 C ATOM 3051 OG SER D 422 61.032 −29.789 −69.505 1.00 30.45 O ATOM 3052 C SER D 422 63.032 −28.581 −71.313 1.00 24.74 C ATOM 3053 O SER D 422 64.146 −29.042 −71.084 1.00 27.42 O ATOM 3054 N ALA D 423 62.417 −28.727 −72.495 1.00 25.27 N ATOM 3055 CA ALA D 423 63.039 −29.420 −73.621 1.00 24.37 C ATOM 3056 CB ALA D 423 61.980 −30.120 −74.487 1.00 23.85 C ATOM 3057 C ALA D 423 63.885 −28.474 −74.481 1.00 23.06 C ATOM 3058 O ALA D 423 64.510 −28.906 −75.443 1.00 21.86 O ATOM 3059 N LEU D 424 63.846 −27.179 −74.173 1.00 23.19 N ATOM 3060 CA LEU D 424 64.551 −26.179 −74.976 1.00 25.64 C ATOM 3061 CB LEU D 424 63.578 −25.115 −75.495 1.00 19.70 C ATOM 3062 CG LEU D 424 62.394 −25.660 −76.338 1.00 25.58 C ATOM 3063 CD1 LEU D 424 61.387 −24.553 −76.624 1.00 24.39 C ATOM 3064 CD2 LEU D 424 62.882 −26.313 −77.638 1.00 25.84 C ATOM 3065 C LEU D 424 65.645 −25.485 −74.180 1.00 25.22 C ATOM 3066 O LEU D 424 65.543 −25.346 −72.967 1.00 28.72 O ATOM 3067 N LEU D 425 66.657 −25.001 −74.885 1.00 25.53 N ATOM 3068 CA LEU D 425 67.682 −24.158 −74.280 1.00 32.98 C ATOM 3069 CB LEU D 425 69.071 −24.752 −74.471 1.00 35.32 C ATOM 3070 CG LEU D 425 69.450 −25.808 −73.446 1.00 42.29 C ATOM 3071 CD1 LEU D 425 70.929 −26.112 −73.572 1.00 42.56 C ATOM 3072 CD2 LEU D 425 69.095 −25.346 −72.042 1.00 45.77 C ATOM 3073 C LEU D 425 67.629 −22.788 −74.877 1.00 40.87 C ATOM 3074 O LEU D 425 67.349 −22.668 −76.088 1.00 33.25 O ATOM 3075 N PRO D 426 68.212 −21.810 −74.155 1.00 45.89 N ATOM 3076 CA PRO D 426 67.610 −20.786 −73.349 1.00 57.87 C ATOM 3077 CB PRO D 426 67.331 −19.679 −74.380 1.00 53.21 C ATOM 3078 CG PRO D 426 68.497 −19.824 −75.359 1.00 54.74 C ATOM 3079 CD PRO D 426 69.193 −21.159 −75.038 1.00 67.18 C ATOM 3080 C PRO D 426 66.365 −21.192 −72.512 1.00 58.45 C ATOM 3081 O PRO D 426 65.411 −21.780 −73.041 1.00 48.30 O ATOM 3082 N THR D 427 66.441 −20.925 −71.198 1.00 66.40 N ATOM 3083 CA THR D 427 65.263 −20.854 −70.308 1.00 67.80 C ATOM 3084 CB THR D 427 65.635 −21.203 −68.848 1.00 60.74 C ATOM 3085 OG1 THR D 427 66.376 −22.426 −68.822 1.00 58.02 O ATOM 3086 CG2 THR D 427 64.381 −21.351 −67.979 1.00 50.29 C ATOM 3087 C THR D 427 64.662 −19.438 −70.333 1.00 71.52 C ATOM 3088 O THR D 427 63.487 −19.234 −70.000 1.00 76.83 O ATOM 3089 ZN ZN E 1 67.618 −37.228 −59.988 1.00 27.99 ZN ATOM 3090 ZN ZN E 2 67.487 −32.570 −80.846 1.00 25.78 ZN ATOM 3091 ZN ZN E 3 4.097 −33.368 −62.459 1.00 18.39 ZN ATOM 3092 ZN ZN E 4 34.532 −10.753 −66.813 1.00 20.66 ZN ATOM 3093 O4 SO4 F 1 53.568 −24.050 −89.945 1.00 27.02 O ATOM 3094 S SO4 F 1 53.601 −25.374 −90.617 1.00 28.11 S ATOM 3095 O1 SO4 F 1 53.923 −25.053 −92.001 1.00 32.61 O ATOM 3096 O2 SO4 F 1 52.338 −26.140 −90.510 1.00 27.60 O ATOM 3097 O3 SO4 F 1 54.655 −26.234 −90.020 1.00 27.04 O ATOM 3098 O4 SO4 F 2 50.231 −19.037 −91.853 1.00 34.18 O ATOM 3099 S SO4 F 2 50.876 −20.322 −92.143 1.00 26.17 S ATOM 3100 O1 SO4 F 2 52.110 −20.082 −92.935 1.00 37.87 O ATOM 3101 O2 SO4 F 2 49.990 −21.173 −92.931 1.00 30.99 O ATOM 3102 O3 SO4 F 2 51.220 −21.044 −90.914 1.00 29.76 O ATOM 3103 O4 SO4 F 3 45.129 −18.809 −88.412 1.00 28.56 O ATOM 3104 S SO4 F 3 46.195 −19.365 −89.235 1.00 32.81 S ATOM 3105 O1 SO4 F 3 47.348 −18.420 −89.377 1.00 28.73 O ATOM 3106 O2 SO4 F 3 45.551 −19.636 −90.540 1.00 49.07 O ATOM 3107 O3 SO4 F 3 46.830 −20.580 −88.652 1.00 35.57 O ATOM 3108 O4 SO4 F 4 26.417 −19.462 −52.350 1.00 33.03 O ATOM 3109 S SO4 F 4 25.795 −19.828 −53.661 1.00 31.11 S ATOM 3110 O1 SO4 F 4 26.701 −19.259 −54.691 1.00 31.40 O ATOM 3111 O2 SO4 F 4 24.383 −19.360 −53.762 1.00 30.81 O ATOM 3112 O3 SO4 F 4 25.697 −21.229 −53.808 1.00 33.31 O ATOM 3113 O4 SO4 F 5 32.829 −35.024 −71.669 1.00 57.21 O ATOM 3114 S SO4 F 5 32.284 −36.387 −71.587 1.00 60.38 S ATOM 3115 O1 SO4 F 5 32.659 −37.161 −72.786 1.00 47.81 O ATOM 3116 O2 SO4 F 5 30.815 −36.320 −71.522 1.00 58.23 O ATOM 3117 O3 SO4 F 5 32.793 −37.041 −70.361 1.00 51.17 O ATOM 3118 O4 SO4 F 6 54.372 −44.362 −51.667 1.00 32.99 O ATOM 3119 S SO4 F 6 53.289 −45.242 −51.226 1.00 32.65 S ATOM 3120 O1 SO4 F 6 53.288 −46.499 −52.033 1.00 28.49 O ATOM 3121 O2 SO4 F 6 52.026 −44.469 −51.301 1.00 35.40 O ATOM 3122 O3 SO4 F 6 53.486 −45.666 −49.862 1.00 40.91 O ATOM 3123 O4 SO4 F 7 49.141 −49.576 −49.719 0.33 24.16 O ATOM 3124 S SO4 F 7 50.191 −50.555 −50.043 0.33 22.72 S ATOM 3125 O1 SO4 F 7 51.120 −50.733 −48.908 0.50 26.94 O ATOM 3126 O2 SO4 F 7 50.930 −50.091 −51.228 0.50 31.15 O ATOM 3127 O3 SO4 F 7 49.597 −51.873 −50.348 0.50 28.00 O ATOM 3128 O4 SO4 F 8 39.942 −33.808 −68.999 1.00 80.40 O ATOM 3129 S SO4 F 8 39.983 −33.670 −70.474 1.00 72.31 S ATOM 3130 O1 SO4 F 8 41.339 −33.212 −70.905 1.00 54.52 O ATOM 3131 O2 SO4 F 8 38.978 −32.671 −70.880 1.00 67.79 O ATOM 3132 O3 SO4 F 8 39.656 −34.972 −71.101 1.00 57.24 O ATOM 3133 O1 tha G 1 32.649 −4.810 −46.725 1.00 20.74 O ATOM 3134 C4 tha G 1 33.736 −4.493 −47.208 1.00 23.72 C ATOM 3135 N1 tha G 1 34.439 −3.448 −46.705 1.00 23.58 N ATOM 3136 C5 tha G 1 35.492 −2.884 −47.320 1.00 27.69 C ATOM 3137 O2 tha G 1 35.998 −1.826 −46.907 1.00 23.56 O ATOM 3138 C3 tha G 1 34.313 −5.273 −48.385 1.00 21.17 C ATOM 3139 C2 tha G 1 35.822 −5.074 −48.482 1.00 22.99 C ATOM 3140 C1 tha G 1 36.047 −3.586 −48.549 1.00 23.94 C ATOM 3141 N tha G 1 37.469 −3.212 −48.671 1.00 33.94 N ATOM 3142 C6 tha G 1 38.045 −2.668 −49.734 1.00 25.81 C ATOM 3143 O3 tha G 1 37.260 −2.381 −50.923 1.00 25.24 O ATOM 3144 C tha G 1 38.458 −3.251 −47.772 1.00 30.12 C ATOM 3145 O tha G 1 38.304 −3.806 −46.444 1.00 26.85 O ATOM 3146 C12 tha G 1 39.752 −2.707 −48.258 1.00 33.22 C ATOM 3147 C11 tha G 1 41.013 −2.561 −47.675 1.00 37.87 C ATOM 3148 C10 tha G 1 42.014 −1.972 −48.458 1.00 32.82 C ATOM 3149 C9 tha G 1 41.737 −1.564 −49.775 1.00 31.86 C ATOM 3150 C8 tha G 1 40.457 −1.729 −50.339 1.00 33.36 C ATOM 3151 C7 tha G 1 39.484 −2.312 −49.541 1.00 31.31 C ATOM 3152 O1 tha H 1 47.266 −37.534 −66.093 1.00 21.69 O ATOM 3153 C4 tha H 1 47.832 −36.498 −66.403 1.00 23.28 C ATOM 3154 N1 tha H 1 47.418 −35.791 −67.471 1.00 24.07 N ATOM 3155 C5 tha H 1 48.038 −34.697 −67.946 1.00 25.82 C ATOM 3156 O2 tha H 1 47.583 −34.121 −68.956 1.00 23.16 O ATOM 3157 C3 tha H 1 49.005 −36.000 −65.601 1.00 19.27 C ATOM 3158 C2 tha H 1 49.179 −34.474 −65.735 1.00 22.11 C ATOM 3159 C1 tha H 1 49.293 −34.204 −67.222 1.00 25.56 C ATOM 3160 N tha H 1 49.513 −32.791 −67.594 1.00 27.31 N ATOM 3161 C6 tha H 1 50.591 −32.281 −68.200 1.00 21.40 C ATOM 3162 O3 tha H 1 51.755 −33.075 −68.500 1.00 22.54 O ATOM 3163 C tha H 1 48.664 −31.743 −67.531 1.00 23.73 C ATOM 3164 O tha H 1 47.327 −31.806 −66.943 1.00 24.82 O ATOM 3165 C12 tha H 1 49.203 −30.492 −68.117 1.00 21.03 C ATOM 3166 C11 tha H 1 48.684 −29.198 −68.256 1.00 25.42 C ATOM 3167 C10 tha H 1 49.530 −28.263 −68.892 1.00 24.97 C ATOM 3168 C9 tha H 1 50.830 −28.634 −69.335 1.00 23.71 C ATOM 3169 C8 tha H 1 51.332 −29.952 −69.185 1.00 21.01 C ATOM 3170 C7 tha H 1 50.478 −30.849 −68.556 1.00 23.19 C ATOM 3171 O1 tha I 1 47.337 −31.704 −75.372 1.00 17.69 O ATOM 3172 C4 tha I 1 47.886 −32.674 −74.932 1.00 22.81 C ATOM 3173 N1 tha I 1 47.416 −33.311 −73.831 1.00 20.72 N ATOM 3174 C5 tha I 1 48.035 −34.360 −73.273 1.00 22.00 C ATOM 3175 O2 tha I 1 47.585 −34.857 −72.231 1.00 24.61 O ATOM 3176 C3 tha I 1 49.124 −33.205 −75.627 1.00 20.77 C ATOM 3177 C2 tha I 1 49.281 −34.709 −75.419 1.00 22.13 C ATOM 3178 C1 tha I 1 49.305 −34.900 −73.916 1.00 23.16 C ATOM 3179 N tha I 1 49.465 −36.310 −73.512 1.00 28.08 N ATOM 3180 C6 tha I 1 50.538 −36.859 −72.935 1.00 25.51 C ATOM 3181 O3 tha I 1 51.733 −36.112 −72.648 1.00 25.38 O ATOM 3182 C tha I 1 48.595 −37.325 −73.536 1.00 27.27 C ATOM 3183 O tha I 1 47.256 −37.214 −74.073 1.00 24.97 O ATOM 3184 C12 tha I 1 49.114 −38.586 −72.942 1.00 28.92 C ATOM 3185 C11 tha I 1 48.580 −39.847 −72.752 1.00 28.01 C ATOM 3186 C10 tha I 1 49.425 −40.783 −72.129 1.00 33.52 C ATOM 3187 C9 tha I 1 50.749 −40.458 −71.733 1.00 30.84 C ATOM 3188 C8 tha I 1 51.256 −39.167 −71.928 1.00 25.90 C ATOM 3189 C7 tha I 1 50.400 −38.272 −72.560 1.00 24.13 C ATOM 3190 O1 tha J 1 24.801 −33.124 −67.097 1.00 20.37 O ATOM 3191 C4 tha J 1 24.183 −34.100 −67.526 1.00 22.00 C ATOM 3192 N1 tha J 1 24.716 −34.860 −68.490 1.00 22.11 N ATOM 3193 C5 tha J 1 24.068 −35.818 −69.151 1.00 25.13 C ATOM 3194 O2 tha J 1 24.555 −36.342 −70.149 1.00 24.55 O ATOM 3195 C3 tha J 1 22.816 −34.486 −66.967 1.00 20.11 C ATOM 3196 C2 tha J 1 22.595 −35.985 −67.165 1.00 23.98 C ATOM 3197 C1 tha J 1 22.708 −36.249 −68.657 1.00 25.08 C ATOM 3198 N tha J 1 22.518 −37.687 −69.024 1.00 26.77 N ATOM 3199 C6 tha J 1 21.454 −38.222 −69.614 1.00 26.80 C ATOM 3200 O3 tha J 1 20.327 −37.391 −69.949 1.00 25.74 O ATOM 3201 C tha J 1 23.338 −38.734 −68.909 1.00 27.97 C ATOM 3202 O tha J 1 24.653 −38.642 −68.325 1.00 30.49 O ATOM 3203 C12 tha J 1 22.799 −40.010 −69.459 1.00 27.99 C ATOM 3204 C11 tha J 1 23.300 −41.301 −69.548 1.00 32.96 C ATOM 3205 C10 tha J 1 22.471 −42.266 −70.154 1.00 37.29 C ATOM 3206 C9 tha J 1 21.192 −41.923 −70.640 1.00 31.51 C ATOM 3207 C8 tha J 1 20.713 −40.608 −70.525 1.00 34.99 C ATOM 3208 C7 tha J 1 21.563 −39.671 −69.932 1.00 29.61 C ATOM 3209 O HOH L 1 15.687 −24.868 −55.044 1.00 18.53 O ATOM 3210 O HOH L 2 50.141 −49.492 −55.581 1.00 18.42 O ATOM 3211 O HOH L 3 16.276 −16.194 −55.792 1.00 25.79 O ATOM 3212 O HOH L 4 24.719 −17.416 −55.839 1.00 18.80 O ATOM 3213 O HOH L 5 56.042 −24.139 −88.387 1.00 23.26 O ATOM 3214 O HOH L 6 52.369 −23.781 −61.646 1.00 54.74 O ATOM 3215 O HOH L 7 55.535 −46.365 −53.456 1.00 22.16 O ATOM 3216 O HOH L 8 8.828 −22.635 −58.171 1.00 18.50 O ATOM 3217 O HOH L 9 14.988 −21.145 −51.047 1.00 17.77 O ATOM 3218 O HOH L 10 62.602 −48.505 −56.129 1.00 24.86 O ATOM 3219 O HOH L 11 65.001 −31.563 −76.089 1.00 25.53 O ATOM 3220 O HOH L 12 14.130 −8.733 −49.754 1.00 21.34 O ATOM 3221 O HOH L 13 23.119 −14.548 −62.918 1.00 20.40 O ATOM 3222 O HOH L 14 21.210 −15.286 −50.733 1.00 17.30 O ATOM 3223 O HOH L 15 57.259 −13.554 −86.198 1.00 25.37 O ATOM 3224 O HOH L 16 24.956 −18.321 −34.540 1.00 38.12 O ATOM 3225 O HOH L 19 47.754 −31.698 −84.578 1.00 22.45 O ATOM 3226 O HOH L 20 21.030 −21.563 −56.566 1.00 19.08 O ATOM 3227 O HOH L 21 71.002 −29.362 −86.145 1.00 36.25 O ATOM 3228 O HOH L 22 23.857 −32.982 −58.161 1.00 23.66 O ATOM 3229 O HOH L 23 2.875 −25.757 −57.166 1.00 20.01 O ATOM 3230 O HOH L 24 32.192 −13.968 −47.044 1.00 25.63 O ATOM 3231 O HOH L 26 49.912 −19.759 −74.422 1.00 19.54 O ATOM 3232 O HOH L 27 13.373 −28.885 −74.194 1.00 27.49 O ATOM 3233 O HOH L 29 48.198 −32.174 −59.017 1.00 29.19 O ATOM 3234 O HOH L 30 31.596 −3.197 −71.615 1.00 29.34 O ATOM 3235 O HOH L 31 29.564 1.563 −58.456 1.00 31.73 O ATOM 3236 O HOH L 32 56.721 −56.721 −56.721 0.33 21.07 O ATOM 3237 O HOH L 33 34.576 −4.582 −56.622 1.00 32.80 O ATOM 3238 O HOH L 34 52.739 −23.483 −87.327 1.00 35.47 O ATOM 3239 O HOH L 35 50.819 −31.948 −58.772 1.00 24.57 O ATOM 3240 O HOH L 36 52.449 −22.563 −94.386 1.00 45.59 O ATOM 3241 O HOH L 37 56.155 −34.208 −76.897 1.00 24.73 O ATOM 3242 O HOH L 38 58.601 −27.291 −69.075 1.00 26.55 O ATOM 3243 O HOH L 39 39.518 −32.027 −76.439 1.00 27.86 O ATOM 3244 O HOH L 40 20.804 −3.252 −50.008 1.00 22.31 O ATOM 3245 O HOH L 41 19.819 −38.478 −66.567 1.00 38.71 O ATOM 3246 O HOH L 42 35.862 −6.990 −55.363 1.00 29.01 O ATOM 3247 O HOH L 43 23.403 −38.735 −60.658 1.00 32.76 O ATOM 3248 O HOH L 44 56.335 −35.307 −63.878 1.00 23.02 O ATOM 3249 O HOH L 45 20.683 −39.095 −60.510 1.00 23.74 O ATOM 3250 O HOH L 46 47.508 −38.125 −57.069 1.00 30.14 O ATOM 3251 O HOH L 47 33.932 −5.710 −64.561 1.00 25.29 O ATOM 3252 O HOH L 48 31.829 −31.634 −63.627 1.00 29.57 O ATOM 3253 O HOH L 49 6.581 −32.724 −67.282 1.00 16.81 O ATOM 3254 O HOH L 50 55.424 −36.395 −75.847 1.00 29.00 O ATOM 3255 O HOH L 52 53.938 −18.795 −74.751 1.00 22.50 O ATOM 3256 O HOH L 53 29.550 −19.261 −53.836 1.00 28.96 O ATOM 3257 O HOH L 54 38.663 −5.963 −51.096 1.00 36.07 O ATOM 3258 O HOH L 55 30.627 −7.838 −39.456 1.00 30.12 O ATOM 3259 O HOH L 56 62.560 −58.143 −63.161 1.00 40.85 O ATOM 3260 O HOH L 57 22.691 −21.161 −68.558 1.00 21.56 O ATOM 3261 O HOH L 58 32.005 −19.832 −60.629 1.00 24.94 O ATOM 3262 O HOH L 59 50.865 −37.985 −81.995 1.00 30.20 O ATOM 3263 O HOH L 60 57.411 −32.713 −74.573 1.00 27.14 O ATOM 3264 O HOH L 62 65.431 −37.990 −65.124 1.00 26.53 O ATOM 3265 O HOH L 63 15.410 −35.574 −65.857 1.00 26.67 O ATOM 3266 O HOH L 64 22.259 −23.786 −52.561 1.00 27.79 O ATOM 3267 O HOH L 65 −0.586 −30.232 −70.323 1.00 23.86 O ATOM 3268 O HOH L 66 30.833 −38.965 −60.588 1.00 38.45 O ATOM 3269 O HOH L 67 38.890 −27.652 −90.787 1.00 43.26 O ATOM 3270 O HOH L 68 14.621 −34.144 −68.435 1.00 27.37 O ATOM 3271 O HOH L 69 55.315 −32.985 −64.970 1.00 32.04 O ATOM 3272 O HOH L 70 39.917 −5.867 −64.037 1.00 37.19 O ATOM 3273 O HOH L 71 59.042 −30.597 −67.840 1.00 49.83 O ATOM 3274 O HOH L 72 39.956 −30.167 −78.435 1.00 26.40 O ATOM 3275 O HOH L 73 38.715 −12.185 −49.915 1.00 26.98 O ATOM 3276 O HOH L 74 34.733 −25.884 −89.162 1.00 44.84 O ATOM 3277 O HOH L 75 14.793 −10.253 −55.318 1.00 25.87 O ATOM 3278 O HOH L 76 43.257 −19.289 −71.654 1.00 35.85 O ATOM 3279 O HOH L 77 54.191 −29.019 −89.699 1.00 26.10 O ATOM 3280 O HOH L 78 56.049 −35.127 −73.022 1.00 40.71 O ATOM 3281 O HOH L 79 53.602 −50.162 −67.499 1.00 25.66 O ATOM 3282 O HOH L 81 19.392 −5.729 −67.548 1.00 50.36 O ATOM 3283 O HOH L 82 48.086 −37.600 −81.927 1.00 33.03 O ATOM 3284 O HOH L 83 33.928 −23.343 −87.740 1.00 43.29 O ATOM 3285 O HOH L 84 45.337 −54.283 −68.061 1.00 24.25 O ATOM 3286 O HOH L 85 40.008 −26.253 −88.773 1.00 32.15 O ATOM 3287 O HOH L 86 62.007 −37.583 −75.462 1.00 30.26 O ATOM 3288 O HOH L 87 26.924 −15.979 −68.699 1.00 22.27 O ATOM 3289 O HOH L 88 54.758 −54.758 −54.758 0.33 29.36 O ATOM 3290 O HOH L 89 4.211 −18.498 −58.358 1.00 29.69 O ATOM 3291 O HOH L 90 19.606 −14.751 −67.753 1.00 25.57 O ATOM 3292 O HOH L 91 55.344 −17.358 −73.069 1.00 39.29 O ATOM 3293 O HOH L 92 15.205 −2.801 −46.301 1.00 27.99 O ATOM 3294 O HOH L 94 62.815 −11.784 −80.085 1.00 48.21 O ATOM 3295 O HOH L 95 67.361 −18.113 −86.396 1.00 29.05 O ATOM 3296 O HOH L 96 16.186 −37.729 −66.798 1.00 29.22 O ATOM 3297 O HOH L 97 16.017 −13.618 −64.796 1.00 31.48 O ATOM 3298 O HOH L 98 8.144 −38.224 −57.733 1.00 31.35 O ATOM 3299 O HOH L 99 55.048 −51.828 −69.233 1.00 37.02 O ATOM 3300 O HOH L 100 69.818 −53.683 −61.252 1.00 48.96 O ATOM 3301 O HOH L 101 66.240 −27.453 −70.201 1.00 44.37 O ATOM 3302 O HOH L 102 31.341 −16.062 −42.771 1.00 38.42 O ATOM 3303 O HOH L 103 72.208 −29.557 −72.934 1.00 33.19 O ATOM 3304 O HOH L 104 23.266 −42.575 −57.325 1.00 46.63 O ATOM 3305 O HOH L 105 25.859 −27.605 −53.579 1.00 34.86 O ATOM 3306 O HOH L 106 70.231 −16.418 −80.824 1.00 42.25 O ATOM 3307 O HOH L 107 58.669 −13.001 −77.376 1.00 32.45 O ATOM 3308 O HOH L 109 40.445 −38.004 −67.661 1.00 37.07 O ATOM 3309 O HOH L 110 17.351 −14.704 −61.888 1.00 24.50 O ATOM 3310 O HOH L 111 2.094 −17.036 −63.913 1.00 38.85 O ATOM 3311 O HOH L 112 33.007 0.435 −69.383 1.00 47.08 O ATOM 3312 O HOH L 113 38.233 −11.754 −47.081 1.00 29.21 O ATOM 3313 O HOH L 114 30.240 −20.982 −62.176 1.00 33.07 O ATOM 3314 O HOH L 115 59.000 −41.676 −72.417 1.00 38.40 O ATOM 3315 O HOH L 116 19.994 −18.861 −69.408 1.00 32.79 O ATOM 3316 O HOH L 117 27.959 −32.428 −55.745 1.00 31.40 O ATOM 3317 O HOH L 118 41.831 −45.805 −65.492 1.00 37.37 O ATOM 3318 O HOH L 119 39.227 −5.519 −61.376 1.00 26.62 O ATOM 3319 O HOH L 120 43.399 −31.422 −86.723 1.00 41.65 O ATOM 3320 O HOH L 121 40.759 −31.942 −59.751 1.00 33.49 O ATOM 3321 O HOH L 122 38.990 −18.743 −56.566 1.00 37.57 O ATOM 3322 O HOH L 124 34.180 −28.803 −83.172 1.00 66.36 O ATOM 3323 O HOH L 125 22.157 −34.743 −55.043 1.00 36.26 O ATOM 3324 O HOH L 126 23.554 −28.381 −52.885 1.00 36.67 O ATOM 3325 O HOH L 127 49.603 −49.326 −67.804 1.00 30.26 O ATOM 3326 O HOH L 128 49.184 −33.675 −87.620 1.00 40.57 O ATOM 3327 O HOH L 129 46.134 −24.500 −91.071 1.00 54.77 O ATOM 3328 O HOH L 131 34.363 −21.085 −61.021 1.00 39.28 O ATOM 3329 O HOH L 132 5.001 −18.000 −67.452 1.00 48.23 O ATOM 3330 O HOH L 133 41.393 −51.695 −53.867 1.00 33.74 O ATOM 3331 O HOH L 134 57.460 −36.666 −66.273 1.00 26.39 O ATOM 3332 O HOH L 135 54.206 −56.313 −60.809 1.00 30.48 O ATOM 3333 O HOH L 136 56.422 −12.436 −79.243 1.00 26.12 O ATOM 3334 O HOH L 137 32.210 −2.412 −75.847 1.00 36.07 O ATOM 3335 O HOH L 138 −1.794 −33.617 −68.497 1.00 31.48 O ATOM 3336 O HOH L 139 19.335 −1.722 −55.280 1.00 39.05 O ATOM 3337 O HOH L 140 31.331 −15.482 −70.862 1.00 29.93 O ATOM 3338 O HOH L 141 9.905 −31.642 −53.142 1.00 27.94 O ATOM 3339 O HOH L 142 8.821 −24.376 −71.208 1.00 29.89 O ATOM 3340 O HOH L 143 63.042 −46.222 −69.149 1.00 38.30 O ATOM 3341 O HOH L 144 17.345 −42.282 −55.006 1.00 44.34 O ATOM 3342 O HOH L 145 55.020 −38.474 −69.945 1.00 34.61 O ATOM 3343 O HOH L 146 18.450 −20.692 −68.957 1.00 30.72 O ATOM 3344 O HOH L 147 42.077 −23.300 −76.781 1.00 32.86 O ATOM 3345 O HOH L 148 58.625 −39.090 −81.652 1.00 60.70 O ATOM 3346 O HOH L 149 51.531 −24.281 −69.517 1.00 34.26 O ATOM 3347 O HOH L 151 45.150 −26.535 −89.054 1.00 34.72 O ATOM 3348 O HOH L 152 31.499 −19.040 −49.210 1.00 38.16 O ATOM 3349 O HOH L 153 37.891 −6.083 −54.755 1.00 33.57 O ATOM 3350 O HOH L 154 66.988 −52.671 −55.719 1.00 30.81 O ATOM 3351 O HOH L 155 45.069 −27.121 −68.805 1.00 40.12 O ATOM 3352 O HOH L 156 3.210 −14.373 −61.150 1.00 38.71 O ATOM 3353 O HOH L 157 39.664 −3.492 −58.805 1.00 45.72 O ATOM 3354 O HOH L 159 53.595 −54.245 −69.104 1.00 43.37 O ATOM 3355 O HOH L 160 54.828 −13.631 −82.091 1.00 26.33 O ATOM 3356 O HOH L 161 20.814 −25.479 −74.702 1.00 58.61 O ATOM 3357 O HOH L 163 19.228 −25.990 −77.787 1.00 48.48 O ATOM 3358 O HOH L 164 67.264 −15.888 −77.412 1.00 48.33 O ATOM 3359 O HOH L 165 42.006 −18.352 −88.476 1.00 33.63 O ATOM 3360 O HOH L 166 25.933 −17.844 −39.812 1.00 31.78 O ATOM 3361 O HOH L 167 37.206 −24.371 −53.780 1.00 39.40 O ATOM 3362 O HOH L 168 37.999 −11.068 −39.807 1.00 42.75 O ATOM 3363 O HOH L 169 73.344 −30.963 −82.523 1.00 40.49 O ATOM 3364 O HOH L 170 36.362 −26.893 −52.369 1.00 36.87 O ATOM 3365 O HOH L 171 62.308 −32.498 −65.409 1.00 37.46 O ATOM 3366 O HOH L 172 17.254 −31.252 −71.362 1.00 33.43 O ATOM 3367 O HOH L 173 40.001 −39.056 −63.160 1.00 31.88 O ATOM 3368 O HOH L 174 49.625 −34.552 −52.605 1.00 44.94 O ATOM 3369 O HOH L 176 20.609 −3.320 −53.976 1.00 31.97 O ATOM 3370 O HOH L 177 39.607 −36.067 −73.555 1.00 39.96 O ATOM 3371 O HOH L 179 40.911 −37.582 −81.155 1.00 42.56 O ATOM 3372 O HOH L 180 32.366 −5.642 −39.007 1.00 37.50 O ATOM 3373 O HOH L 181 38.412 −18.866 −63.601 1.00 46.78 O ATOM 3374 O HOH L 183 23.962 −5.949 −41.743 1.00 38.92 O ATOM 3375 O HOH L 184 38.101 −18.926 −51.774 1.00 42.05 O ATOM 3376 O HOH L 185 33.742 −17.263 −48.603 1.00 40.25 O ATOM 3377 O HOH L 186 61.142 −31.392 −90.072 1.00 28.73 O ATOM 3378 O HOH L 187 37.584 −16.568 −42.204 1.00 53.14 O ATOM 3379 O HOH L 189 40.534 −31.244 −73.750 1.00 32.02 O ATOM 3380 O HOH L 190 13.600 −39.173 −54.119 1.00 40.73 O ATOM 3381 O HOH L 192 48.744 −41.484 −84.299 1.00 40.90 O ATOM 3382 O HOH L 193 30.427 −24.885 −65.755 1.00 35.31 O ATOM 3383 O HOH L 194 31.790 −3.373 −39.852 1.00 35.52 O ATOM 3384 O HOH L 195 39.482 −49.661 −51.476 1.00 43.93 O ATOM 3385 O HOH L 197 67.361 −52.465 −64.836 1.00 43.12 O ATOM 3386 O HOH L 198 3.320 −34.365 −70.523 1.00 31.27 O ATOM 3387 O HOH L 199 37.825 −39.366 −61.254 1.00 43.02 O ATOM 3388 O HOH L 200 38.849 −36.273 −77.550 1.00 42.21 O ATOM 3389 O HOH L 201 65.151 −25.188 −70.176 1.00 37.38 O ATOM 3390 O HOH L 203 18.713 −38.229 −53.728 1.00 49.01 O ATOM 3391 O HOH L 206 34.839 −22.018 −82.723 1.00 50.80 O ATOM 3392 O HOH L 207 42.650 −25.189 −90.764 1.00 44.63 O ATOM 3393 O HOH L 208 4.356 −15.540 −63.217 1.00 38.03 O ATOM 3394 O HOH L 209 43.320 −38.463 −54.937 1.00 44.13 O ATOM 3395 O HOH L 211 76.029 −28.331 −85.901 1.00 57.13 O ATOM 3396 O HOH L 212 56.366 −26.141 −65.497 1.00 39.95 O ATOM 3397 O HOH L 213 9.305 −38.562 −67.431 1.00 36.28 O ATOM 3398 O HOH L 214 13.767 −7.728 −63.610 1.00 42.90 O ATOM 3399 O HOH L 215 41.452 −36.154 −70.496 1.00 37.07 O ATOM 3400 O HOH L 216 38.839 −15.497 −61.917 1.00 33.52 O ATOM 3401 O HOH L 217 1.308 −33.231 −72.057 1.00 36.29 O ATOM 3402 O HOH L 219 49.869 −31.383 −89.375 1.00 44.40 O ATOM 3403 O HOH L 220 61.475 −49.641 −72.537 1.00 50.76 O ATOM 3404 O HOH L 221 61.166 −39.487 −51.137 1.00 33.15 O ATOM 3405 O HOH L 223 21.276 −36.732 −53.795 1.00 48.63 O ATOM 3406 O HOH L 224 30.813 −21.851 −51.107 1.00 47.68 O ATOM 3407 O HOH L 225 48.521 −21.025 −67.416 1.00 50.19 O ATOM 3408 O HOH L 226 18.429 −24.372 −56.098 1.00 39.59 O ATOM 3409 O HOH L 227 53.694 −41.460 −87.578 1.00 38.29 O ATOM 3410 O HOH L 228 13.969 −14.370 −66.634 1.00 34.12 O ATOM 3411 O HOH L 229 40.230 −11.784 −41.009 1.00 49.09 O ATOM 3412 O HOH L 230 6.830 −21.656 −74.018 1.00 50.79 O ATOM 3413 O HOH L 231 6.370 −30.440 −50.445 1.00 35.75 O ATOM 3414 O HOH L 233 47.555 −29.458 −60.157 1.00 35.84 O ATOM 3415 O HOH L 234 67.711 −55.008 −63.991 1.00 39.36 O ATOM 3416 O HOH L 235 18.254 −37.505 −71.346 1.00 39.21 O ATOM 3417 O HOH L 236 50.344 −27.293 −92.014 1.00 47.07 O ATOM 3418 O HOH L 237 14.476 −14.568 −69.530 1.00 52.40 O ATOM 3419 O HOH L 238 24.003 −41.225 −61.832 1.00 35.95 O ATOM 3420 O HOH L 239 62.939 −22.994 −72.369 1.00 37.23 O ATOM 3421 O HOH L 240 15.132 −36.153 −70.002 1.00 37.73 O ATOM 3422 O HOH L 241 37.454 −1.305 −53.238 1.00 38.09 O ATOM 3423 O HOH L 242 17.252 −19.234 −70.577 1.00 40.42 O ATOM 3424 O HOH L 243 1.304 −38.421 −56.467 1.00 31.41 O ATOM 3425 O HOH L 244 8.930 −34.037 −51.990 1.00 37.56 O ATOM 3426 O HOH L 245 8.559 −29.551 −51.831 1.00 40.49 O ATOM 3427 O HOH L 246 35.787 −20.582 −51.226 1.00 43.29 O ATOM 3428 O HOH L 247 34.824 −3.225 −65.250 1.00 31.64 O ATOM 3429 O HOH L 248 22.672 −16.662 −34.081 1.00 46.02 O ATOM 3430 O HOH L 249 75.262 −40.190 −59.792 1.00 41.19 O ATOM 3431 O HOH L 250 22.962 0.248 −57.829 1.00 40.96 O ATOM 3432 O HOH L 251 25.981 0.591 −71.688 0.50 24.89 O ATOM 3433 O HOH L 252 63.706 −56.018 −57.061 1.00 30.50 O ATOM 3434 O HOH L 253 54.040 −33.292 −69.581 1.00 41.72 O ATOM 3435 O HOH L 254 31.642 −1.034 −54.424 1.00 40.44 O ATOM 3436 O HOH L 255 31.894 −32.875 −68.582 1.00 38.12 O ATOM 3437 O HOH L 256 64.430 −30.335 −93.014 1.00 36.75 O ATOM 3438 O HOH L 257 51.606 −48.445 −47.516 1.00 35.56 O ATOM 3439 O HOH L 258 14.775 −5.738 −59.449 1.00 41.76 O ATOM 3440 O HOH L 259 41.671 −49.537 −61.972 1.00 37.02 O ATOM 3441 O HOH L 260 31.930 −51.902 −57.220 1.00 41.09 O ATOM 3442 O HOH L 318 40.656 −10.643 −46.436 1.00 48.66 O ATOM 3443 O HOH L 319 36.632 −32.374 −81.505 1.00 43.88 O ATOM 3444 O HOH L 320 68.355 −33.475 −72.601 1.00 39.03 O ATOM 3445 O HOH L 321 20.142 −19.865 −40.472 1.00 43.62 O ATOM 3446 O HOH L 322 55.509 −21.896 −63.050 1.00 61.99 O ATOM 3447 O HOH L 323 44.019 −45.006 −69.659 1.00 41.56 O ATOM 3448 O HOH L 324 48.406 −28.659 −56.758 1.00 35.63 O ATOM 3449 O HOH L 325 22.016 −11.423 −35.128 1.00 42.67 O ATOM 3450 O HOH L 328 38.454 −17.463 −69.431 1.00 42.17 O ATOM 3451 O HOH L 329 61.742 −31.652 −71.038 1.00 44.53 O ATOM 3452 O HOH L 330 42.263 −40.186 −81.271 1.00 48.24 O ATOM 3453 O HOH L 331 49.976 −26.005 −71.185 1.00 47.01 O ATOM 3454 O HOH L 333 26.720 −18.070 −44.965 1.00 47.61 O ATOM 3455 O HOH L 335 43.194 −28.288 −88.825 1.00 55.66 O ATOM 3456 O HOH L 336 66.480 −36.523 −76.859 1.00 58.80 O ATOM 3457 O HOH L 337 35.490 −19.711 −90.890 1.00 47.63 O ATOM 3458 O HOH L 338 39.878 −37.252 −65.509 1.00 46.45 O ATOM 3459 O HOH L 340 62.966 −32.900 −55.399 1.00 37.54 O ATOM 3460 O HOH L 341 31.868 −4.880 −77.701 1.00 39.79 O ATOM 3461 O HOH L 342 36.203 −3.882 −61.128 1.00 39.23 O ATOM 3462 O HOH L 343 42.685 −0.657 −42.764 1.00 43.15 O ATOM 3463 O HOH L 344 40.818 −5.215 −45.096 1.00 56.07 O ATOM 3464 O HOH L 346 66.722 −22.108 −81.794 1.00 56.72 O ATOM 3465 O HOH L 348 55.966 −41.575 −79.472 1.00 49.96 O ATOM 3466 O HOH L 349 44.585 −60.475 −75.365 1.00 48.56 O ATOM 3467 O HOH L 350 28.321 −18.140 −42.798 1.00 48.85 O ATOM 3468 O HOH L 351 36.711 −12.525 −69.413 1.00 62.02 O ATOM 3469 O HOH L 352 23.475 −1.669 −44.351 1.00 50.11 O ATOM 3470 O HOH L 353 32.683 −34.482 −74.566 1.00 42.64 O ATOM 3471 O HOH L 354 42.598 −42.479 −53.181 1.00 54.04 O ATOM 3472 O HOH L 355 45.226 −27.496 −59.852 1.00 56.54 O ATOM 3473 O HOH L 356 48.705 −23.071 −71.479 1.00 42.28 O ATOM 3474 O HOH L 357 64.200 −40.843 −48.240 1.00 47.71 O ATOM 3475 O HOH L 358 42.462 −57.325 −79.655 1.00 55.02 O ATOM 3476 O HOH L 359 61.857 −37.082 −49.618 1.00 43.95 O ATOM 3477 O HOH L 360 69.801 −49.760 −56.992 1.00 35.21 O ATOM 3478 O HOH L 361 25.528 −14.672 −70.983 1.00 47.17 O ATOM 3479 O HOH L 362 9.448 −41.468 −63.620 1.00 45.28 O ATOM 3480 O HOH L 364 40.318 −20.441 −66.053 1.00 56.41 O ATOM 3481 O HOH L 365 7.020 −26.697 −73.127 1.00 44.25 O ATOM 3482 O HOH L 367 48.565 −24.330 −92.755 1.00 46.91 O ATOM 3483 O HOH L 368 54.933 −30.591 −71.122 1.00 39.83 O ATOM 3484 O HOH L 369 47.106 −24.178 −95.234 1.00 60.27 O ATOM 3485 O HOH L 370 35.148 −33.345 −60.155 1.00 36.82 O ATOM 3486 O HOH L 371 64.203 −11.806 −73.783 1.00 46.01 O ATOM 3487 O HOH L 372 2.006 −14.612 −65.015 1.00 51.51 O ATOM 3488 O HOH L 373 65.637 −36.074 −74.556 1.00 50.95 O ATOM 3489 O HOH L 374 59.802 −38.574 −74.031 1.00 50.58 O ATOM 3490 O HOH L 375 13.879 −38.462 −61.263 1.00 85.18 O ATOM 3491 O HOH L 376 61.763 −34.002 −90.900 1.00 39.47 O ATOM 3492 O HOH L 378 40.289 −13.680 −42.954 1.00 45.75 O ATOM 3493 O HOH L 379 33.129 −28.516 −51.743 1.00 64.82 O ATOM 3494 O HOH L 382 42.921 −25.366 −65.742 1.00 57.36 O ATOM 3495 O HOH L 383 42.791 −19.175 −74.336 1.00 43.59 O ATOM 3496 O HOH L 384 53.243 −34.346 −84.660 1.00 63.91 O ATOM 3497 O HOH L 385 25.954 8.497 −50.232 1.00 53.53 O ATOM 3498 O HOH L 388 59.804 −31.394 −53.029 1.00 65.02 O ATOM 3499 O HOH L 389 50.780 −22.230 −72.760 1.00 33.62 O ATOM 3500 O HOH L 390 26.340 −3.601 −60.202 1.00 64.75 O ATOM 3501 O HOH L 391 28.129 −25.852 −51.071 1.00 46.50 O ATOM 3502 O HOH L 393 14.154 −7.292 −57.036 1.00 36.09 O ATOM 3503 O HOH L 397 37.422 −20.224 −46.867 1.00 69.67 O ATOM 3504 O HOH L 398 37.165 −35.258 −81.376 1.00 44.63 O ATOM 3505 O HOH L 400 22.752 −7.309 −70.576 1.00 53.33 O ATOM 3506 O HOH L 401 63.020 −10.241 −71.323 1.00 57.90 O ATOM 3507 O HOH L 402 47.411 −48.771 −53.710 1.00 41.80 O ATOM 3508 O HOH L 403 25.259 −18.469 −61.248 1.00 52.14 O ATOM 3509 O HOH L 406 27.197 −40.973 −58.632 1.00 47.94 O ATOM 3510 O HOH L 407 19.218 −2.737 −68.050 1.00 80.35 O ATOM 3511 O HOH L 408 34.045 −37.292 −60.300 1.00 48.46 O ATOM 3512 O HOH L 409 38.079 −14.004 −48.990 1.00 57.05 O ATOM 3513 O HOH L 410 68.493 −23.786 −69.129 1.00 57.46 O ATOM 3514 O HOH L 412 35.863 −27.309 −81.341 1.00 57.62 O ATOM 3515 O HOH L 413 43.397 −38.381 −88.954 1.00 59.21 O ATOM 3516 O HOH L 414 29.038 −25.674 −69.827 1.00 50.18 O ATOM 3517 O HOH L 415 38.214 −20.548 −62.410 1.00 47.80 O ATOM 3518 O HOH L 416 38.066 −58.766 −76.704 1.00 108.60 O ATOM 3519 O HOH L 417 40.397 −19.342 −70.694 1.00 50.29 O ATOM 3520 O HOH L 418 18.178 −21.139 −78.978 1.00 51.89 O ATOM 3521 O HOH L 420 24.201 −9.978 −36.105 1.00 54.93 O ATOM 3522 O HOH L 421 34.155 −34.691 −58.438 1.00 43.66 O ATOM 3523 O HOH L 422 48.926 −11.244 −62.863 1.00 59.34 O ATOM 3524 O HOH L 423 66.056 −32.537 −73.870 1.00 41.33 O ATOM 3525 O HOH L 424 12.775 −11.201 −65.750 1.00 58.59 O ATOM 3526 O HOH L 425 50.865 −34.999 −61.675 1.00 48.86 O ATOM 3527 O HOH L 427 36.098 −18.817 −49.819 1.00 55.72 O ATOM 3528 O HOH L 428 42.444 −11.260 −57.047 1.00 48.82 O ATOM 3529 O HOH L 429 19.126 −4.696 −70.541 1.00 60.29 O ATOM 3530 O HOH L 430 44.422 −20.507 −59.266 1.00 58.82 O ATOM 3531 O HOH L 434 41.488 −44.139 −70.800 1.00 45.75 O ATOM 3532 O HOH L 435 37.748 −20.285 −58.136 1.00 69.72 O ATOM 3533 O HOH L 436 6.736 −37.548 −54.063 1.00 51.47 O ATOM 3534 O HOH L 437 40.302 −20.411 −90.763 1.00 48.84 O ATOM 3535 O HOH L 438 51.936 −14.318 −74.016 1.00 63.98 O ATOM 3536 O HOH L 439 35.775 −42.192 −51.221 1.00 68.50 O ATOM 3537 O HOH L 440 31.059 −22.571 −64.147 1.00 41.43 O ATOM 3538 O HOH L 441 38.952 −22.237 −59.564 1.00 66.15 O ATOM 3539 O HOH L 443 21.653 −21.658 −41.663 1.00 55.01 O ATOM 3540 O HOH L 444 45.934 −37.282 −89.854 1.00 77.52 O ATOM 3541 O HOH L 445 49.404 −22.222 −95.458 1.00 46.52 O ATOM 3542 O HOH L 447 36.141 −17.190 −48.065 1.00 76.63 O ATOM 3543 O HOH L 448 43.357 −8.198 −66.460 1.00 44.89 O ATOM 3544 O HOH L 450 26.356 −38.679 −52.157 1.00 60.56 O ATOM 3545 O HOH L 451 29.155 −44.336 −52.040 1.00 63.24 O ATOM 3546 O HOH L 452 12.995 −12.330 −68.262 1.00 47.16 O ATOM 3547 O HOH L 453 25.708 −7.592 −35.823 1.00 55.17 O ATOM 3548 O HOH L 456 39.290 −48.097 −78.072 1.00 44.75 O ATOM 3549 O HOH L 457 39.633 −46.097 −75.983 1.00 55.61 O ATOM 3550 O HOH L 458 44.789 −55.609 −78.400 1.00 53.98 O ATOM 3551 O HOH L 459 42.624 −5.991 −47.762 1.00 47.34 O ATOM 3552 O HOH L 460 27.298 −19.154 −47.330 1.00 49.15 O ATOM 3553 O HOH L 461 37.021 −18.360 −71.526 1.00 37.33 O ATOM 3554 O HOH L 462 65.590 −31.078 −55.377 1.00 47.85 O ATOM 3555 O HOH L 463 33.060 −15.229 −40.224 1.00 50.46 O ATOM 3556 O HOH L 464 24.892 −20.182 −48.125 1.00 43.16 O ATOM 3557 O HOH L 465 29.460 −41.184 −60.394 1.00 53.06 O ATOM 3558 O HOH L 466 37.928 −19.983 −92.336 1.00 51.84 O ATOM 3559 O HOH L 467 63.218 −10.543 −75.851 1.00 43.94 O ATOM 3560 O HOH L 469 25.231 −42.054 −59.855 1.00 53.14 O ATOM 3561 O HOH L 470 64.008 −10.820 −78.548 1.00 53.06 O ATOM 3562 O HOH L 471 47.546 −40.121 −80.753 1.00 44.37 O ATOM 3563 O HOH L 472 51.031 −40.891 −81.788 1.00 51.25 O ATOM 3564 O HOH L 473 45.074 −43.805 −52.942 1.00 44.56 O ATOM 3565 O HOH L 474 47.261 −42.514 −51.929 1.00 51.34 O ATOM 3566 O HOH L 475 31.206 −27.290 −53.325 1.00 43.72 O ATOM 3567 O HOH L 476 27.504 −20.579 −50.009 1.00 42.93 O ATOM 3568 O HOH L 477 33.038 −20.830 −49.848 1.00 41.85 O ATOM 3569 O HOH L 478 34.566 −17.368 −41.666 1.00 61.85 O ATOM 3570 O HOH L 479 40.793 −8.591 −44.126 1.00 39.32 O ATOM 3571 O HOH L 480 47.451 −25.402 −71.374 1.00 36.75 O ATOM 3572 O HOH L 481 42.703 −22.365 −74.608 1.00 40.31 O ATOM 3573 O HOH L 482 27.821 0.433 −65.034 1.00 37.12 O ATOM 3574 O HOH L 483 53.711 −35.490 −71.518 1.00 47.76 O ATOM 3575 O HOH L 484 60.386 −43.312 −74.062 1.00 43.55 O ATOM 3576 O HOH L 485 55.953 −28.281 −61.541 1.00 50.31 O END

TABLE 6 Atomic coordinates for CRBN:DDB1: Compound B (Human protein) HEADER ----                            xx-xxx-xx xxxx COMPND --- REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0107 REMARK 3 AUTHORS : MURSHUDOV, SKUBAK, LEBEDEV, PANNU, REMARK 3  STEINER, NICHOLLS, WINN, LONG, VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.05 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.01 REMARK 3 DATA CUTOFF (SIGMA(F)) : NONE REMARK 3 COMPLETENESS FOR RANGE (%) : 99.88 REMARK 3 NUMBER OF REFLECTIONS : 44722 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.19939 REMARK 3 R VALUE (WORKING SET) : 0.19552 REMARK 3 FREE R VALUE : 0.27388 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.0 REMARK 3 FREE R VALUE TEST SET COUNT : 2360 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH : 3.050 REMARK 3 BIN RESOLUTION RANGE LOW : 3.129 REMARK 3 REFLECTION IN BIN (WORKING SET) : 3217 REMARK 3 BIN COMPLETENESS (WORKING + TEST) (%) : 99.24 REMARK 3 BIN R VALUE (WORKING SET) : 0.338 REMARK 3 BIN FREE R VALUE SET COUNT : 170 REMARK 3 BIN FREE R VALUE : 0.367 REMARK 3 REMARK 3 NUMBER OF NON−HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 ALL ATOMS : 11203 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 66.267 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : −1.58 REMARK 3 B22 (A**2) :  0.92 REMARK 3 B33 (A**2) :  0.66 REMARK 3 B12 (A**2) :  0.00 REMARK 3 B13 (A**2) :  0.00 REMARK 3 B23 (A**2) :  0.00 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A) : NULL REMARK 3 ESU BASED ON FREE R VALUE (A) : 0.425 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A) : 0.318 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2) : 37.619 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.932 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.889 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 11426 ;  0.018 ;  0.019 REMARK 3 BOND LENGTHS OTHERS (A): 10793 ;  0.002 ;  0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 15525 ;  2.170 ;  1.960 REMARK 3 BOND ANGLES OTHERS (DEGREES): 24721 ;  1.198 ;  2.998 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES):  1438 ; 10.001 ;  5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES):  479 ; 38.842 ; 24.509 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES):  1885 ; 21.358 ; 15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES):   54 ; 21.493 ; 15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3):  1806 ;  0.120 ;  0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 12897 ;  0.010 ;  0.021 REMARK 3 GENERAL PLANES OTHERS (A):  2546 ;  0.002 ;  0.020 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2):  5800 ;  4.224 ;  6.618 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2):  5799 ;  4.220 ;  6.618 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  7222 ;  6.795 ;  9.915 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2) :  7223 ;  6.795 ;  9.915 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2):  5626 ;  4.335 ;  7.005 REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2) :  5625 ;  4.335 ;  7.005 REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2) :  8304 ;  7.018 ; 10.352 REMARK 3 LONG RANGE B REFINED ATOMS (A**2) : 11997 ; 10.042 ; 51.862 REMARK 3 LONG RANGE B OTHER ATOMS (A**2) : 11998 ; 10.042 ; 51.863 REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 TWIN DETAILS REMARK 3 NUMBER OF TWIN DOMAINS : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 4 REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3 TLS GROUP : 1 REMARK 3 NUMBER OF COMPONENTS GROUP : 1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE : C 249 C 500 REMARK 3 ORIGIN FOR THE GROUP (A): 33.3654 41.9729 −41.4237 REMARK 3 T TENSOR REMARK 3 T11:  0.1446 T22:  0.0795 REMARK 3 T33:  0.0393 T12: −0.0516 REMARK 3 T13:  0.0063 T23:  0.0170 REMARK 3 L TENSOR REMARK 3 L11:  0.7796 L22:  0.8042 REMARK 3 L33:  0.5164 L12:  0.4556 REMARK 3 L13: −0.5729 L23: −0.5351 REMARK 3 S TENSOR REMARK 3 S11: −0.0778 S12:  0.1035 S13:  0.0076 REMARK 3 S21:  0.0089 S22:  0.0384 S23: −0.0762 REMARK 3 S31:  0.0871 S32: −0.0718 S33:  0.0395 REMARK 3 REMARK 3 TLS GROUP : 2 REMARK 3 NUMBER OF COMPONENTS GROUP : 1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE : C 1 C 186 REMARK 3 ORIGIN FOR THE GROUP (A): 36.5549 48.4341 −20.4615 REMARK 3 T TENSOR REMARK 3 T11:  0.1568 T22:  0.0389 REMARK 3 T33:  0.0846 T12: −0.0032 REMARK 3 T13: −0.0522 T23: −0.0273 REMARK 3 L TENSOR REMARK 3 L11:  0.8462 L22:  0.1050 REMARK 3 L33:  1.7469 L12:  0.2400 REMARK 3 L13: −0.6199 L23: −0.3871 REMARK 3 S TENSOR REMARK 3 S11: −0.0249 S12: −0.1579 S13: 0.1794 REMARK 3 S21: −0.0033 S22: −0.0303 S23: 0.0248 REMARK 3 S31:  0.0092 S32:  0.0825 S33: 0.0551 REMARK 3 REMARK 3 TLS GROUP : 3 REMARK 3 NUMBER OF COMPONENTS GROUP : 1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE : A 392 A 709 REMARK 3 ORIGIN FOR THE GROUP (A): −51.9624 12.4713 −21.7463 REMARK 3 T TENSOR REMARK 3 T11:  0.1123 T22:  0.0568 REMARK 3 T33:  0.1861 T12:  0.0446 REMARK 3 T13:  0.0023 T23: −0.0742 REMARK 3 L TENSOR REMARK 3 L11:  0.9429 L22:  0.7862 REMARK 3 L33:  0.6826 L12: −0.0382 REMARK 3 L13:  0.5800 L23: −0.1420 REMARK 3 S TENSOR REMARK 3 S11: −0.2064 S12: −0.0720 S13: 0.1271 REMARK 3 S21:  0.0658 S22: −0.0429 S23: 0.1679 REMARK 3 S31: −0.0799 S32: −0.0980 S33: 0.2493 REMARK 3 REMARK 3 TLS GROUP : 4 REMARK 3 NUMBER OF COMPONENTS GROUP : 2 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE : A 1 A 391 REMARK 3 RESIDUE RANGE : A 710 A 1200 REMARK 3 ORIGIN FOR THE GROUP (A): −1.7398 16.1076 −23.5039 REMARK 3 T TENSOR REMARK 3 T11:  0.1786 T22:  0.0449 REMARK 3 T33:  0.0159 T12: −0.0188 REMARK 3 T13:  0.0281 T23: −0.0203 REMARK 3 L TENSOR REMARK 3 L11:  0.2717 L22:  0.3466 REMARK 3 L33:  0.4327 L12:  0.0020 REMARK 3 L13:  0.0605 L23:  0.0146 REMARK 3 S TENSOR REMARK 3 S11: −0.0545 S12: −0.0318 S13: −0.0054 REMARK 3 S21: −0.0789 S22:  0.0717 S23: −0.0222 REMARK 3 S31:  0.0079 S32:  0.0666 S33: −0.0172 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS REMARK 3 U VALUES : RESIDUAL ONLY REMARK 3 LINKR GLN A 209 ASN A 211 gap LINKR LYS A 287 THR A 296 gap LINKR LEU A 546 GLY A 551 gap LINKR ASP A 744 THR A 749 gap LINKR LYS A 769 GLU A 784 gap LINKR ASP A 980 GLU A 987 gap LINKR MET A 1014 THR A 1024 gap LINKR THR A 1078 LYS A 1081 gap LINKR ASP A 1116 LYS A 1121 gap LINKR SER C 126 GLU C 132 gap LINKR VAL C 213 SER C 220 gap LINKR ASP C 265 ASP C 270 gap LINKR ARG A 391 ILE A 707 gap LINKR ALA A 46 LEU A 49 gap LINKR GLN A 93 SER A 97 gap LINKR ASN A 337 GLU A 342 gap LINKR GLU A 368 GLN A 372 gap LINKR ARG A 391 LEU A 710 gap LINKR SER A 767 GLU A 784 gap LINKR VAL A 1013 THR A1024 gap LINKR PRO A 417 GLU A 420 gap LINKR HIS A 536 VAL A 538 gap LINKR GLU A 535 VAL A 538 gap LINKR LEU A 560 THR A 562 gap LINKR LEU A 576 HIS A 578 gap LINKR GLY A 584 ILE A 586 gap LINKR SER A 643 SER A 645 gap LINKR SER A 661 ASN A 663 gap LINKR ASP A 625 LYS A 627 gap LINKR ASP C 265 SER C 272 gap LINKR THR C 172 GLY C 176 gap SSBOND 1 CYS A 18 CYS A 313 SSBOND 2 CYS C 323 CYS C 326 SSBOND 3 CYS C 326 CYS C 391 SSBOND 4 CYS C 326 CYS C 394 CRYST1 111.029 126.886 172.487 90.00 90.00 90.00 P 21 21 21 SCALE1 0.009007 0.000000 0.000000 0.00000 SCALE2 0.000000 0.007881 0.000000 0.00000 SCALE3 0.000000 0.000000 0.005798 0.00000 ATOM 1 N SER A 2 −10.005 42.968 −18.390 1.00 84.59 N ATOM 2 CA SER A 2 −10.680 41.660 −18.759 1.00 84.02 C ATOM 3 CB SER A 2 −10.098 40.978 −20.050 1.00 80.59 C ATOM 4 OG SER A 2 −11.107 40.512 −20.977 1.00 68.86 O ATOM 5 C SER A 2 −10.680 40.705 −17.540 1.00 77.34 C ATOM 6 O SER A 2 −9.765 40.653 −16.724 1.00 68.49 O ATOM 7 N TYR A 3 −11.782 39.985 −17.463 1.00 73.95 N ATOM 8 CA TYR A 3 −12.165 39.195 −16.352 1.00 68.46 C ATOM 9 CB TYR A 3 −13.255 39.929 −15.615 1.00 71.81 C ATOM 10 CG TYR A 3 −12.847 41.291 −15.165 1.00 75.50 C ATOM 11 CD1 TYR A 3 −11.744 41.461 −14.330 1.00 78.09 C ATOM 12 CE1 TYR A 3 −11.378 42.721 −13.905 1.00 83.18 C ATOM 13 CZ TYR A 3 −12.115 43.828 −14.324 1.00 81.80 C ATOM 14 OH TYR A 3 −11.784 45.088 −13.895 1.00 83.08 O ATOM 15 CE2 TYR A 3 −13.209 43.673 −15.145 1.00 78.84 C ATOM 16 CD2 TYR A 3 −13.573 42.412 −15.554 1.00 76.19 C ATOM 17 C TYR A 3 −12.734 37.917 −16.932 1.00 61.62 C ATOM 18 O TYR A 3 −13.895 37.851 −17.355 1.00 52.94 O ATOM 19 N ASN A 4 −11.902 36.901 −16.976 1.00 57.85 N ATOM 20 CA ASN A 4 −12.321 35.666 −17.563 1.00 55.67 C ATOM 21 CB ASN A 4 −11.317 35.325 −18.628 1.00 57.30 C ATOM 22 CG ASN A 4 −11.151 36.492 −19.603 1.00 62.49 C ATOM 23 OD1 ASN A 4 −12.040 36.782 −20.436 1.00 66.61 O ATOM 24 ND2 ASN A 4 −10.050 37.214 −19.457 1.00 64.50 N ATOM 25 C ASN A 4 −12.599 34.578 −16.529 1.00 52.23 C ATOM 26 O ASN A 4 −12.102 34.646 −15.364 1.00 48.64 O ATOM 27 N TYR A 5 −13.485 33.653 −16.949 1.00 49.26 N ATOM 28 CA TYR A 5 −13.885 32.446 −16.211 1.00 46.57 C ATOM 29 CB TYR A 5 −15.356 32.526 −16.020 1.00 42.94 C ATOM 30 CG TYR A 5 −16.033 31.410 −15.286 1.00 45.14 C ATOM 31 CD1 TYR A 5 −16.548 30.337 −15.963 1.00 47.98 C ATOM 32 CE1 TYR A 5 −17.264 29.328 −15.291 1.00 50.62 C ATOM 33 CZ TYR A 5 −17.487 29.396 −13.934 1.00 47.26 C ATOM 34 OH TYR A 5 −18.186 28.367 −13.354 1.00 48.08 O ATOM 35 CE2 TYR A 5 −16.990 30.463 −13.235 1.00 45.13 C ATOM 36 CD2 TYR A 5 −16.268 31.466 −13.911 1.00 45.20 C ATOM 37 C TYR A 5 −13.508 31.200 −17.040 1.00 47.62 C ATOM 38 O TYR A 5 −13.928 31.103 −18.188 1.00 47.74 O ATOM 39 N VAL A 6 −12.673 30.293 −16.495 1.00 48.08 N ATOM 40 CA VAL A 6 −12.357 29.004 −17.167 1.00 46.07 C ATOM 41 CB VAL A 6 −10.878 28.681 −17.307 1.00 44.74 C ATOM 42 CG1 VAL A 6 −10.662 27.785 −18.497 1.00 43.45 C ATOM 43 CG2 VAL A 6 −10.111 29.929 −17.495 1.00 49.07 C ATOM 44 C VAL A 6 −12.848 27.813 −16.404 1.00 46.12 C ATOM 45 O VAL A 6 −12.553 27.621 −15.205 1.00 48.25 O ATOM 46 N VAL A 7 −13.448 26.934 −17.175 1.00 44.72 N ATOM 47 CA VAL A 7 −14.034 25.743 −16.655 1.00 44.24 C ATOM 48 CB VAL A 7 −15.521 25.973 −16.450 1.00 45.37 C ATOM 49 CG1 VAL A 7 −16.233 26.282 −17.781 1.00 45.99 C ATOM 50 CG2 VAL A 7 −16.140 24.770 −15.768 1.00 45.70 C ATOM 51 C VAL A 7 −13.828 24.547 −17.595 1.00 41.83 C ATOM 52 O VAL A 7 −13.747 24.688 −18.845 1.00 37.16 O ATOM 53 N THR A 8 −13.779 23.380 −16.961 1.00 37.39 N ATOM 54 CA THR A 8 −13.697 22.157 −17.662 1.00 35.46 C ATOM 55 CB THR A 8 −13.181 21.093 −16.748 1.00 36.27 C ATOM 56 OG1 THR A 8 −11.813 21.332 −16.485 1.00 34.13 O ATOM 57 CG2 THR A 8 −13.309 19.719 −17.392 1.00 39.98 C ATOM 58 C THR A 8 −15.048 21.721 −18.163 1.00 35.87 C ATOM 59 O THR A 8 −15.974 21.614 −17.435 1.00 39.59 O ATOM 60 N ALA A 9 −15.145 21.437 −19.440 1.00 37.76 N ATOM 61 CA ALA A 9 −16.332 20.833 −20.020 1.00 35.23 C ATOM 62 CB ALA A 9 −16.547 21.348 −21.430 1.00 35.30 C ATOM 63 C ALA A 9 −16.129 19.360 −20.066 1.00 35.17 C ATOM 64 O ALA A 9 −17.093 18.630 −20.056 1.00 34.48 O ATOM 65 N GLN A 10 −14.886 18.916 −20.217 1.00 35.76 N ATOM 66 CA GLN A 10 −14.626 17.509 −20.344 1.00 37.64 C ATOM 67 CB GLN A 10 −14.782 17.125 −21.811 1.00 39.11 C ATOM 68 CG GLN A 10 −14.144 15.810 −22.211 1.00 40.34 C ATOM 69 CD GLN A 10 −14.767 14.636 −21.506 1.00 41.11 C ATOM 70 OE1 GLN A 10 −15.990 14.462 −21.537 1.00 42.09 O ATOM 71 NE2 GLN A 10 −13.938 13.816 −20.881 1.00 39.93 N ATOM 72 C GLN A 10 −13.255 17.204 −19.825 1.00 36.43 C ATOM 73 O GLN A 10 −12.280 17.662 −20.376 1.00 36.13 O ATOM 74 N LYS A 11 −13.180 16.398 −18.778 1.00 37.80 N ATOM 75 CA LYS A 11 −11.900 16.197 −18.065 1.00 38.32 C ATOM 76 CB LYS A 11 −12.082 15.375 −16.800 1.00 39.91 C ATOM 77 CG LYS A 11 −13.334 15.538 −15.953 1.00 40.69 C ATOM 78 CD LYS A 11 −13.025 14.736 −14.700 1.00 43.83 C ATOM 79 CE LYS A 11 −14.176 14.656 −13.730 1.00 48.32 C ATOM 80 NZ LYS A 11 −13.924 13.619 −12.717 1.00 49.18 N ATOM 81 C LYS A 11 −10.941 15.413 −18.953 1.00 37.06 C ATOM 82 O LYS A 11 −11.377 14.631 −19.798 1.00 38.42 O ATOM 83 N PRO A 12 −9.650 15.571 −18.760 1.00 33.78 N ATOM 84 CA PRO A 12 −8.765 14.870 −19.653 1.00 35.08 C ATOM 85 CB PRO A 12 −7.406 15.212 −19.113 1.00 34.44 C ATOM 86 CG PRO A 12 −7.647 15.285 −17.680 1.00 34.64 C ATOM 87 CD PRO A 12 −8.971 15.938 −17.541 1.00 34.11 C ATOM 88 C PRO A 12 −8.943 13.367 −19.615 1.00 36.15 C ATOM 89 O PRO A 12 −9.142 12.778 −18.521 1.00 37.55 O ATOM 90 N THR A 13 −8.896 12.773 −20.811 1.00 36.27 N ATOM 91 CA THR A 13 −9.132 11.333 −21.018 1.00 35.76 C ATOM 92 CB THR A 13 −10.047 11.109 −22.200 1.00 35.92 C ATOM 93 OG1 THR A 13 −9.438 11.700 −23.355 1.00 38.97 O ATOM 94 CG2 THR A 13 −11.418 11.772 −21.974 1.00 34.88 C ATOM 95 C THR A 13 −7.886 10.543 −21.275 1.00 35.29 C ATOM 96 O THR A 13 −7.846 9.386 −20.996 1.00 39.16 O ATOM 97 N ALA A 14 −6.869 11.140 −21.843 1.00 36.74 N ATOM 98 CA ALA A 14 −5.603 10.442 −22.029 1.00 39.22 C ATOM 99 CB ALA A 14 −4.619 11.411 −22.649 1.00 41.48 C ATOM 100 C ALA A 14 −4.984 9.855 −20.758 1.00 38.94 C ATOM 101 O ALA A 14 −4.860 10.531 −19.765 1.00 44.16 O ATOM 102 N VAL A 15 −4.539 8.619 −20.813 1.00 38.42 N ATOM 103 CA VAL A 15 −3.978 7.954 −19.642 1.00 37.06 C ATOM 104 CB VAL A 15 −4.170 6.429 −19.693 1.00 35.55 C ATOM 105 CG1 VAL A 15 −3.238 5.738 −18.714 1.00 36.66 C ATOM 106 CG2 VAL A 15 −5.609 6.057 −19.376 1.00 34.82 C ATOM 107 C VAL A 15 −2.523 8.166 −19.687 1.00 37.80 C ATOM 108 O VAL A 15 −1.949 7.979 −20.693 1.00 40.33 O ATOM 109 N ASN A 16 −1.903 8.452 −18.566 1.00 40.97 N ATOM 110 CA ASN A 16 −0.459 8.573 −18.515 1.00 40.13 C ATOM 111 CB ASN A 16 −0.080 10.056 −18.431 1.00 44.35 C ATOM 112 CG ASN A 16 −0.672 10.772 −17.225 1.00 44.80 C ATOM 113 OD1 ASN A 16 −1.826 11.218 −17.240 1.00 51.01 O ATOM 114 ND2 ASN A 16 0.123 10.923 −16.208 1.00 42.58 N ATOM 115 C ASN A 16 0.189 7.791 −17.406 1.00 37.75 C ATOM 116 O ASN A 16 1.364 7.857 −17.258 1.00 37.18 O ATOM 117 N GLY A 17 −0.548 7.033 −16.624 1.00 38.59 N ATOM 118 CA GLY A 17 0.087 6.065 −15.710 1.00 39.54 C ATOM 119 C GLY A 17 −0.914 5.038 −15.268 1.00 38.90 C ATOM 120 O GLY A 17 −2.124 5.259 −15.266 1.00 38.60 O ATOM 121 N CYS A 18 −0.433 3.880 −14.930 1.00 40.51 N ATOM 122 CA CYS A 18 −1.355 2.813 −14.554 1.00 43.49 C ATOM 123 CB CYS A 18 −1.912 2.059 −15.775 1.00 43.52 C ATOM 124 SG CYS A 18 −0.742 1.558 −17.087 1.00 53.82 S ATOM 125 C CYS A 18 −0.555 1.948 −13.633 1.00 45.19 C ATOM 126 O CYS A 18 0.468 1.435 −14.030 1.00 51.75 O ATOM 127 N VAL A 19 −0.935 1.857 −12.376 1.00 44.40 N ATOM 128 CA VAL A 19 −0.222 0.975 −11.487 1.00 46.98 C ATOM 129 CB VAL A 19 0.442 1.843 −10.440 1.00 49.42 C ATOM 130 CG1 VAL A 19 −0.443 1.981 −9.210 1.00 49.10 C ATOM 131 CG2 VAL A 19 1.807 1.292 −10.093 1.00 55.84 C ATOM 132 C VAL A 19 −1.191 −0.066 −10.899 1.00 45.76 C ATOM 133 O VAL A 19 −2.410 0.162 −10.916 1.00 45.49 O ATOM 134 N THR A 20 −0.697 −1.208 −10.410 1.00 44.39 N ATOM 135 CA THR A 20 −1.601 −2.080 −9.551 1.00 44.15 C ATOM 136 CB THR A 20 −2.044 −3.444 −10.140 1.00 42.52 C ATOM 137 OG1 THR A 20 −0.967 −4.068 −10.840 1.00 39.92 O ATOM 138 CG2 THR A 20 −3.189 −3.226 −11.085 1.00 44.71 C ATOM 139 C THR A 20 −1.061 −2.356 −8.205 1.00 42.58 C ATOM 140 O THR A 20 0.111 −2.109 −7.950 1.00 39.44 O ATOM 141 N GLY A 21 −1.938 −2.804 −7.323 1.00 45.46 N ATOM 142 CA GLY A 21 −1.585 −3.083 −5.956 1.00 50.92 C ATOM 143 C GLY A 21 −2.814 −3.159 −5.090 1.00 54.49 C ATOM 144 O GLY A 21 −3.915 −3.221 −5.593 1.00 54.79 O ATOM 145 N HIS A 22 −2.617 −3.163 −3.782 1.00 55.62 N ATOM 146 CA HIS A 22 −3.710 −3.223 −2.841 1.00 57.07 C ATOM 147 CB HIS A 22 −3.482 −4.417 −1.959 1.00 56.33 C ATOM 148 CG HIS A 22 −3.095 −5.633 −2.728 1.00 57.50 C ATOM 149 ND1 HIS A 22 −1.791 −5.926 −3.038 1.00 55.59 N ATOM 150 CE1 HIS A 22 −1.748 −7.037 −3.742 1.00 57.44 C ATOM 151 NE2 HIS A 22 −2.980 −7.471 −3.905 1.00 61.30 N ATOM 152 CD2 HIS A 22 −3.843 −6.606 −3.288 1.00 57.01 C ATOM 153 C HIS A 22 −3.692 −1.944 −2.056 1.00 61.31 C ATOM 154 O HIS A 22 −2.839 −1.736 −1.215 1.00 67.92 O ATOM 155 N PHE A 23 −4.662 −1.099 −2.361 1.00 57.84 N ATOM 156 CA PHE A 23 −4.797 0.229 −1.826 1.00 54.40 C ATOM 157 CB PHE A 23 −4.869 1.125 −3.052 1.00 51.67 C ATOM 158 CG PHE A 23 −4.812 2.580 −2.776 1.00 47.77 C ATOM 159 CD1 PHE A 23 −3.777 3.123 −2.088 1.00 51.37 C ATOM 160 CE1 PHE A 23 −3.722 4.468 −1.858 1.00 50.75 C ATOM 161 CZ PHE A 23 −4.696 5.278 −2.345 1.00 47.09 C ATOM 162 CE2 PHE A 23 −5.721 4.745 −3.049 1.00 47.31 C ATOM 163 CD2 PHE A 23 −5.767 3.403 −3.270 1.00 46.08 C ATOM 164 C PHE A 23 −6.041 0.411 −1.008 1.00 54.06 C ATOM 165 O PHE A 23 −6.023 0.981 0.057 1.00 57.62 O ATOM 166 N THR A 24 −7.133 −0.075 −1.549 1.00 51.51 N ATOM 167 CA THR A 24 −8.451 0.016 −0.928 1.00 54.42 C ATOM 168 CB THR A 24 −9.599 −0.360 −1.883 1.00 53.56 C ATOM 169 OG1 THR A 24 −9.423 −1.679 −2.375 1.00 54.48 O ATOM 170 CG2 THR A 24 −9.678 0.544 −3.051 1.00 55.64 C ATOM 171 C THR A 24 −8.560 −0.915 0.278 1.00 61.90 C ATOM 172 O THR A 24 −9.071 −0.526 1.326 1.00 66.84 O ATOM 173 N SER A 25 −8.104 −2.153 0.105 1.00 63.86 N ATOM 174 CA SER A 25 −7.987 −3.120 1.185 1.00 59.57 C ATOM 175 CB SER A 25 −9.259 −3.978 1.256 1.00 57.48 C ATOM 176 OG SER A 25 −9.060 −5.284 0.771 1.00 56.66 O ATOM 177 C SER A 25 −6.758 −3.940 0.865 1.00 59.31 C ATOM 178 O SER A 25 −6.319 −3.878 −0.257 1.00 64.84 O ATOM 179 N ALA A 26 −6.184 −4.682 1.817 1.00 60.38 N ATOM 180 CA ALA A 26 −5.119 −5.672 1.477 1.00 58.27 C ATOM 181 CB ALA A 26 −4.361 −6.142 2.701 1.00 57.76 C ATOM 182 C ALA A 26 −5.694 −6.869 0.756 1.00 56.16 C ATOM 183 O ALA A 26 −5.011 −7.471 −0.053 1.00 50.43 O ATOM 184 N GLU A 27 −6.943 −7.207 1.089 1.00 59.21 N ATOM 185 CA GLU A 27 −7.636 −8.367 0.545 1.00 60.96 C ATOM 186 CB GLU A 27 −8.688 −8.896 1.592 1.00 56.04 C ATOM 187 C GLU A 27 −8.151 −8.053 −0.927 1.00 62.67 C ATOM 188 O GLU A 27 −8.305 −8.966 −1.725 1.00 64.25 O ATOM 189 N ASP A 28 −8.322 −6.769 −1.295 1.00 68.07 N ATOM 190 CA ASP A 28 −8.676 −6.296 −2.696 1.00 64.97 C ATOM 191 CB ASP A 28 −9.342 −4.896 −2.655 1.00 70.98 C ATOM 192 CG ASP A 28 −10.809 −4.909 −2.160 1.00 81.59 C ATOM 193 OD1 ASP A 28 −11.519 −5.936 −2.365 1.00 88.28 O ATOM 194 OD2 ASP A 28 −11.257 −3.860 −1.592 1.00 82.95 O ATOM 195 C ASP A 28 −7.490 −6.101 −3.649 1.00 59.18 C ATOM 196 O ASP A 28 −6.414 −5.701 −3.223 1.00 56.48 O ATOM 197 N LEU A 29 −7.707 −6.324 −4.947 1.00 56.71 N ATOM 198 CA LEU A 29 −6.738 −5.920 −5.998 1.00 57.16 C ATOM 199 CB LEU A 29 −6.425 −7.079 −6.947 1.00 57.01 C ATOM 200 CG LEU A 29 −5.559 −6.793 −8.210 1.00 58.50 C ATOM 201 CD1 LEU A 29 −4.074 −6.769 −7.858 1.00 59.51 C ATOM 202 CD2 LEU A 29 −5.806 −7.767 −9.360 1.00 57.56 C ATOM 203 C LEU A 29 −7.229 −4.683 −6.823 1.00 58.74 C ATOM 204 O LEU A 29 −8.267 −4.728 −7.521 1.00 63.17 O ATOM 205 N ASN A 30 −6.466 −3.614 −6.815 1.00 53.74 N ATOM 206 CA ASN A 30 −6.923 −2.502 −7.588 1.00 51.53 C ATOM 207 CB ASN A 30 −7.267 −1.274 −6.739 1.00 49.39 C ATOM 208 CG ASN A 30 −7.347 −1.560 −5.277 1.00 48.46 C ATOM 209 OD1 ASN A 30 −6.392 −1.988 −4.688 1.00 46.09 O ATOM 210 ND2 ASN A 30 −8.476 −1.293 −4.684 1.00 47.58 N ATOM 211 C ASN A 30 −5.965 −2.055 −8.636 1.00 53.94 C ATOM 212 O ASN A 30 −4.783 −2.276 −8.564 1.00 54.39 O ATOM 213 N LEU A 31 −6.558 −1.431 −9.629 1.00 54.06 N ATOM 214 CA LEU A 31 −5.914 −0.716 −10.755 1.00 50.28 C ATOM 215 CB LEU A 31 −6.591 −1.108 −12.074 1.00 47.02 C ATOM 216 CG LEU A 31 −6.142 −0.333 −13.309 1.00 47.50 C ATOM 217 CD1 LEU A 31 −4.646 −0.514 −13.546 1.00 48.13 C ATOM 218 CD2 LEU A 31 −6.940 −0.767 −14.512 1.00 46.65 C ATOM 219 C LEU A 31 −6.067 0.822 −10.507 1.00 48.29 C ATOM 220 O LEU A 31 −7.167 1.312 −10.426 1.00 47.24 O ATOM 221 N LEU A 32 −4.976 1.557 −10.356 1.00 45.68 N ATOM 222 CA LEU A 32 −5.051 3.001 −10.249 1.00 46.81 C ATOM 223 CB LEU A 32 −4.159 3.518 −9.118 1.00 46.95 C ATOM 224 CG LEU A 32 −4.677 3.443 −7.694 1.00 44.05 C ATOM 225 CD1 LEU A 32 −5.199 2.070 −7.389 1.00 45.61 C ATOM 226 CD2 LEU A 32 −3.514 3.750 −6.808 1.00 43.43 C ATOM 227 C LEU A 32 −4.572 3.587 −11.562 1.00 47.78 C ATOM 228 O LEU A 32 −3.585 3.109 −12.116 1.00 49.17 O ATOM 229 N ILE A 33 −5.249 4.632 −12.032 1.00 45.97 N ATOM 230 CA ILE A 33 −4.977 5.205 −13.323 1.00 43.78 C ATOM 231 CB ILE A 33 −6.131 4.975 −14.290 1.00 43.88 C ATOM 232 CG1 ILE A 33 −6.379 3.515 −14.465 1.00 44.63 C ATOM 233 CD1 ILE A 33 −7.532 3.296 −15.405 1.00 46.56 C ATOM 234 CG2 ILE A 33 −5.817 5.491 −15.686 1.00 44.67 C ATOM 235 C ILE A 33 −4.863 6.684 −13.170 1.00 43.69 C ATOM 236 O ILE A 33 −5.692 7.316 −12.535 1.00 46.07 O ATOM 237 N ALA A 34 −3.892 7.257 −13.842 1.00 42.80 N ATOM 238 CA ALA A 34 −3.683 8.674 −13.817 1.00 44.29 C ATOM 239 CB ALA A 34 −2.251 8.957 −13.479 1.00 46.42 C ATOM 240 C ALA A 34 −4.018 9.293 −15.151 1.00 45.93 C ATOM 241 O ALA A 34 −3.613 8.820 −16.171 1.00 48.30 O ATOM 242 N LYS A 35 −4.771 10.368 −15.133 1.00 43.83 N ATOM 243 CA LYS A 35 −5.129 11.050 −16.337 1.00 40.65 C ATOM 244 CB LYS A 35 −6.599 10.877 −16.577 1.00 40.87 C ATOM 245 CG LYS A 35 −6.978 9.473 −16.930 1.00 43.41 C ATOM 246 CD LYS A 35 −8.446 9.434 −17.230 1.00 45.09 C ATOM 247 CE LYS A 35 −8.926 8.056 −17.569 1.00 45.60 C ATOM 248 NZ LYS A 35 −10.335 8.139 −18.004 1.00 47.53 N ATOM 249 C LYS A 35 −4.799 12.493 −16.092 1.00 40.40 C ATOM 250 O LYS A 35 −5.659 13.324 −15.964 1.00 42.60 O ATOM 251 N ASN A 36 −3.519 12.787 −16.035 1.00 37.09 N ATOM 252 CA ASN A 36 −3.093 14.127 −15.763 1.00 36.27 C ATOM 253 CB ASN A 36 −3.755 15.081 −16.727 1.00 35.86 C ATOM 254 CG ASN A 36 −3.013 16.362 −16.848 1.00 37.24 C ATOM 255 OD1 ASN A 36 −1.909 16.476 −16.379 1.00 37.08 O ATOM 256 ND2 ASN A 36 −3.616 17.329 −17.481 1.00 37.78 N ATOM 257 C ASN A 36 −3.400 14.481 −14.329 1.00 37.89 C ATOM 258 O ASN A 36 −2.707 14.054 −13.445 1.00 40.16 O ATOM 259 N THR A 37 −4.417 15.293 −14.106 1.00 38.17 N ATOM 260 CA THR A 37 −4.806 15.738 −12.798 1.00 40.11 C ATOM 261 CB THR A 37 −5.428 17.114 −12.888 1.00 41.86 C ATOM 262 OG1 THR A 37 −6.662 17.017 −13.565 1.00 42.82 O ATOM 263 CG2 THR A 37 −4.589 18.006 −13.662 1.00 43.11 C ATOM 264 C THR A 37 −5.842 14.883 −12.128 1.00 41.82 C ATOM 265 O THR A 37 −6.227 15.170 −11.034 1.00 41.39 O ATOM 266 N ARG A 38 −6.308 13.842 −12.781 1.00 39.83 N ATOM 267 CA ARG A 38 −7.318 13.001 −12.210 1.00 38.83 C ATOM 268 CB ARG A 38 −8.414 12.739 −13.208 1.00 41.00 C ATOM 269 CG ARG A 38 −8.831 13.938 −13.992 1.00 41.76 C ATOM 270 CD ARG A 38 −9.426 14.964 −13.086 1.00 44.75 C ATOM 271 NE ARG A 38 −10.597 14.444 −12.432 1.00 49.28 N ATOM 272 CZ ARG A 38 −11.237 15.074 −11.472 1.00 48.98 C ATOM 273 NH1 ARG A 38 −10.819 16.237 −11.064 1.00 53.26 N ATOM 274 NH2 ARG A 38 −12.298 14.542 −10.933 1.00 48.71 N ATOM 275 C ARG A 38 −6.741 11.696 −11.870 1.00 38.00 C ATOM 276 O ARG A 38 −5.896 11.215 −12.554 1.00 35.90 O ATOM 277 N LEU A 39 −7.201 11.118 −10.786 1.00 40.06 N ATOM 278 CA LEU A 39 −6.750 9.792 −10.375 1.00 41.84 C ATOM 279 CB LEU A 39 −5.927 9.873 −9.105 1.00 43.12 C ATOM 280 CG LEU A 39 −5.725 8.587 −8.301 1.00 46.34 C ATOM 281 CD1 LEU A 39 −4.813 7.662 −9.040 1.00 49.46 C ATOM 282 CD2 LEU A 39 −5.104 8.811 −6.939 1.00 48.22 C ATOM 283 C LEU A 39 −8.002 8.972 −10.169 1.00 41.92 C ATOM 284 O LEU A 39 −8.756 9.308 −9.305 1.00 38.88 O ATOM 285 N GLU A 40 −8.217 7.950 −11.016 1.00 44.57 N ATOM 286 CA GLU A 40 −9.313 6.998 −10.912 1.00 45.38 C ATOM 287 CB GLU A 40 −9.805 6.507 −12.280 1.00 50.07 C ATOM 288 CG GLU A 40 −10.120 7.598 −13.287 1.00 57.71 C ATOM 289 CD GLU A 40 −10.523 7.134 −14.710 1.00 67.78 C ATOM 290 OE1 GLU A 40 −9.991 6.138 −15.364 1.00 68.04 O ATOM 291 OE2 GLU A 40 −11.419 7.850 −15.202 1.00 74.59 O ATOM 292 C GLU A 40 −8.733 5.812 −10.173 1.00 44.48 C ATOM 293 O GLU A 40 −7.561 5.489 −10.377 1.00 41.61 O ATOM 294 N ILE A 41 −9.573 5.187 −9.338 1.00 42.45 N ATOM 295 CA ILE A 41 −9.291 3.967 −8.604 1.00 41.53 C ATOM 296 CB ILE A 41 −9.347 4.196 −7.103 1.00 43.60 C ATOM 297 CG1 ILE A 41 −8.354 5.297 −6.679 1.00 45.83 C ATOM 298 CD1 ILE A 41 −8.530 5.784 −5.235 1.00 45.22 C ATOM 299 CG2 ILE A 41 −9.158 2.855 −6.383 1.00 43.64 C ATOM 300 C ILE A 41 −10.375 2.926 −8.799 1.00 41.93 C ATOM 301 O ILE A 41 −11.482 3.055 −8.261 1.00 42.01 O ATOM 302 N TYR A 42 −10.029 1.838 −9.475 1.00 43.54 N ATOM 303 CA TYR A 42 −10.921 0.658 −9.603 1.00 41.62 C ATOM 304 CB TYR A 42 −10.939 0.156 −11.023 1.00 38.45 C ATOM 305 CG TYR A 42 −11.274 1.171 −12.010 1.00 37.06 C ATOM 306 CD1 TYR A 42 −10.316 2.002 −12.480 1.00 38.41 C ATOM 307 CE1 TYR A 42 −10.599 2.945 −13.447 1.00 39.71 C ATOM 308 CZ TYR A 42 −11.863 3.046 −13.949 1.00 39.45 C ATOM 309 OH TYR A 42 −12.092 4.007 −14.901 1.00 45.31 O ATOM 310 CE2 TYR A 42 −12.849 2.206 −13.501 1.00 37.36 C ATOM 311 CD2 TYR A 42 −12.543 1.268 −12.539 1.00 36.89 C ATOM 312 C TYR A 42 −10.498 −0.528 −8.698 1.00 41.55 C ATOM 313 O TYR A 42 −9.376 −0.579 −8.201 1.00 36.79 O ATOM 314 N VAL A 43 −11.434 −1.461 −8.515 1.00 45.04 N ATOM 315 CA VAL A 43 −11.160 −2.801 −8.013 1.00 50.19 C ATOM 316 CB VAL A 43 −12.189 −3.241 −6.956 1.00 53.38 C ATOM 317 CG1 VAL A 43 −11.959 −4.707 −6.556 1.00 54.50 C ATOM 318 CG2 VAL A 43 −12.110 −2.336 −5.732 1.00 54.66 C ATOM 319 C VAL A 43 −11.301 −3.771 −9.163 1.00 51.12 C ATOM 320 O VAL A 43 −12.323 −3.763 −9.866 1.00 53.29 O ATOM 321 N VAL A 44 −10.299 −4.618 −9.334 1.00 52.42 N ATOM 322 CA VAL A 44 −10.370 −5.680 −10.346 1.00 58.09 C ATOM 323 CB VAL A 44 −8.981 −6.354 −10.556 1.00 57.94 C ATOM 324 CG1 VAL A 44 −9.112 −7.584 −11.421 1.00 59.05 C ATOM 325 CG2 VAL A 44 −7.967 −5.398 −11.173 1.00 56.40 C ATOM 326 C VAL A 44 −11.391 −6.741 −9.896 1.00 59.01 C ATOM 327 O VAL A 44 −11.396 −7.131 −8.734 1.00 54.04 O ATOM 328 N THR A 45 −12.246 −7.184 −10.816 1.00 65.90 N ATOM 329 CA THR A 45 −13.176 −8.324 −10.590 1.00 71.66 C ATOM 330 CB THR A 45 −14.672 −7.851 −10.641 1.00 71.96 C ATOM 331 OG1 THR A 45 −15.022 −7.321 −11.938 1.00 64.98 O ATOM 332 CG2 THR A 45 −14.956 −6.778 −9.551 1.00 73.02 C ATOM 333 C THR A 45 −12.944 −9.422 −11.648 1.00 73.92 C ATOM 334 O THR A 45 −12.219 −9.206 −12.598 1.00 77.65 O ATOM 335 N ALA A 46 −13.561 −10.587 −11.520 1.00 80.17 N ATOM 336 CA ALA A 46 −13.721 −11.436 −12.724 1.00 86.24 C ATOM 337 CB ALA A 46 −14.284 −12.818 −12.401 1.00 83.20 C ATOM 338 C ALA A 46 −14.611 −10.702 −13.749 1.00 87.72 C ATOM 339 O ALA A 46 −14.206 −10.503 −14.890 1.00 90.98 O ATOM 340 N GLU A 47 −15.792 −10.261 −13.316 1.00 89.49 N ATOM 341 CA GLU A 47 −16.701 −9.465 −14.156 1.00 90.43 C ATOM 342 CB GLU A 47 −17.893 −8.987 −13.284 1.00 88.71 C ATOM 343 C GLU A 47 −16.011 −8.291 −14.993 1.00 88.98 C ATOM 344 O GLU A 47 −16.504 −7.938 −16.066 1.00 81.51 O ATOM 345 N GLY A 48 −14.879 −7.736 −14.518 1.00 85.76 N ATOM 346 CA GLY A 48 −14.080 −6.714 −15.246 1.00 81.62 C ATOM 347 C GLY A 48 −13.445 −5.680 −14.298 1.00 78.10 C ATOM 348 O GLY A 48 −12.698 −6.059 −13.379 1.00 77.53 O ATOM 349 N LEU A 49 −13.727 −4.383 −14.494 1.00 68.51 N ATOM 350 CA LEU A 49 −13.249 −3.336 −13.545 1.00 63.27 C ATOM 351 CB LEU A 49 −12.455 −2.271 −14.294 1.00 59.90 C ATOM 352 CG LEU A 49 −11.110 −2.629 −14.905 1.00 58.85 C ATOM 353 CD1 LEU A 49 −10.583 −1.417 −15.642 1.00 59.12 C ATOM 354 CD2 LEU A 49 −10.100 −3.047 −13.853 1.00 59.16 C ATOM 355 C LEU A 49 −14.361 −2.620 −12.771 1.00 60.19 C ATOM 356 O LEU A 49 −15.175 −1.940 −13.381 1.00 56.21 O ATOM 357 N ARG A 50 −14.369 −2.716 −11.436 1.00 61.26 N ATOM 358 CA ARG A 50 −15.347 −1.953 −10.605 1.00 60.73 C ATOM 359 CB ARG A 50 −15.777 −2.697 −9.334 1.00 65.22 C ATOM 360 CG ARG A 50 −17.053 −2.113 −8.685 1.00 69.70 C ATOM 361 CD ARG A 50 −17.830 −3.126 −7.816 1.00 71.57 C ATOM 362 NE ARG A 50 −16.955 −3.992 −6.991 1.00 74.61 N ATOM 363 CZ ARG A 50 −16.271 −3.600 −5.895 1.00 75.28 C ATOM 364 NH1 ARG A 50 −16.331 −2.340 −5.436 1.00 75.08 N ATOM 365 NH2 ARG A 50 −15.505 −4.475 −5.237 1.00 71.43 N ATOM 366 C ARG A 50 −14.775 −0.615 −10.184 1.00 56.25 C ATOM 367 O ARG A 50 −13.807 −0.580 −9.431 1.00 51.30 O ATOM 368 N PRO A 51 −15.341 0.477 −10.657 1.00 53.20 N ATOM 369 CA PRO A 51 −14.854 1.792 −10.309 1.00 53.44 C ATOM 370 CB PRO A 51 −15.740 2.665 −11.142 1.00 50.63 C ATOM 371 CG PRO A 51 −17.037 1.990 −11.049 1.00 49.90 C ATOM 372 CD PRO A 51 −16.773 0.527 −10.932 1.00 52.19 C ATOM 373 C PRO A 51 −15.179 2.035 −8.878 1.00 52.86 C ATOM 374 O PRO A 51 −16.243 1.657 −8.485 1.00 55.49 O ATOM 375 N VAL A 52 −14.300 2.651 −8.111 1.00 53.63 N ATOM 376 CA VAL A 52 −14.582 2.885 −6.713 1.00 51.53 C ATOM 377 CB VAL A 52 −13.606 2.064 −5.873 1.00 49.44 C ATOM 378 CG1 VAL A 52 −13.616 2.451 −4.417 1.00 51.21 C ATOM 379 CG2 VAL A 52 −13.975 0.619 −5.981 1.00 51.50 C ATOM 380 C VAL A 52 −14.554 4.347 −6.302 1.00 52.93 C ATOM 381 O VAL A 52 −15.473 4.838 −5.686 1.00 54.55 O ATOM 382 N LYS A 53 −13.471 5.023 −6.614 1.00 50.17 N ATOM 383 CA LYS A 53 −13.346 6.400 −6.256 1.00 45.90 C ATOM 384 CB LYS A 53 −12.685 6.467 −4.893 1.00 47.97 C ATOM 385 CG LYS A 53 −12.451 7.845 −4.310 1.00 51.37 C ATOM 386 CD LYS A 53 −13.734 8.489 −3.856 1.00 50.93 C ATOM 387 CE LYS A 53 −13.483 9.798 −3.160 1.00 51.75 C ATOM 388 NZ LYS A 53 −14.783 10.384 −2.776 1.00 54.36 N ATOM 389 C LYS A 53 −12.515 7.126 −7.262 1.00 46.86 C ATOM 390 O LYS A 53 −11.514 6.646 −7.681 1.00 45.60 O ATOM 391 N GLU A 54 −12.939 8.313 −7.624 1.00 45.96 N ATOM 392 CA GLU A 54 −12.207 9.179 −8.499 1.00 44.79 C ATOM 393 CB GLU A 54 −12.991 9.244 −9.802 1.00 46.24 C ATOM 394 CG GLU A 54 −12.244 9.722 −11.042 1.00 47.42 C ATOM 395 CD GLU A 54 −12.343 11.194 −11.269 1.00 48.07 C ATOM 396 OE1 GLU A 54 −11.714 11.711 −12.228 1.00 51.06 O ATOM 397 OE2 GLU A 54 −13.044 11.835 −10.469 1.00 51.51 O ATOM 398 C GLU A 54 −11.997 10.569 −7.857 1.00 44.13 C ATOM 399 O GLU A 54 −12.816 11.045 −7.103 1.00 49.02 O ATOM 400 N VAL A 55 −10.872 11.203 −8.146 1.00 45.67 N ATOM 401 CA VAL A 55 −10.499 12.489 −7.555 1.00 44.91 C ATOM 402 CB VAL A 55 −9.737 12.382 −6.206 1.00 41.77 C ATOM 403 CG1 VAL A 55 −10.610 11.698 −5.174 1.00 40.41 C ATOM 404 CG2 VAL A 55 −8.384 11.683 −6.375 1.00 41.94 C ATOM 405 C VAL A 55 −9.588 13.266 −8.438 1.00 44.68 C ATOM 406 O VAL A 55 −8.776 12.689 −9.129 1.00 51.52 O ATOM 407 N GLY A 56 −9.717 14.579 −8.347 1.00 44.93 N ATOM 408 CA GLY A 56 −8.743 15.514 −8.828 1.00 44.77 C ATOM 409 C GLY A 56 −7.590 15.771 −7.838 1.00 44.25 C ATOM 410 O GLY A 56 −7.665 15.473 −6.637 1.00 38.93 O ATOM 411 N MET A 57 −6.493 16.290 −8.404 1.00 46.35 N ATOM 412 CA MET A 57 −5.432 16.979 −7.673 1.00 45.06 C ATOM 413 CB MET A 57 −4.143 16.171 −7.654 1.00 45.30 C ATOM 414 CG MET A 57 −4.354 14.869 −6.929 1.00 45.32 C ATOM 415 SD MET A 57 −2.856 13.935 −6.744 1.00 56.85 S ATOM 416 CE MET A 57 −1.599 15.123 −6.263 1.00 53.91 C ATOM 417 C MET A 57 −5.255 18.337 −8.318 1.00 42.08 C ATOM 418 O MET A 57 −5.836 18.628 −9.346 1.00 39.26 O ATOM 419 N TYR A 58 −4.532 19.172 −7.614 1.00 42.61 N ATOM 420 CA TYR A 58 −4.183 20.489 −8.055 1.00 43.63 C ATOM 421 CB TYR A 58 −4.306 21.394 −6.873 1.00 45.17 C ATOM 422 CG TYR A 58 −5.703 21.788 −6.424 1.00 44.09 C ATOM 423 CD1 TYR A 58 −6.807 21.735 −7.228 1.00 40.68 C ATOM 424 CE1 TYR A 58 −8.038 22.174 −6.756 1.00 42.09 C ATOM 425 CZ TYR A 58 −8.154 22.687 −5.483 1.00 43.38 C ATOM 426 OH TYR A 58 −9.313 23.184 −4.901 1.00 46.14 O ATOM 427 CE2 TYR A 58 −7.069 22.751 −4.708 1.00 43.26 C ATOM 428 CD2 TYR A 58 −5.865 22.313 −5.164 1.00 44.52 C ATOM 429 C TYR A 58 −2.732 20.371 −8.500 1.00 44.78 C ATOM 430 O TYR A 58 −1.780 20.961 −7.929 1.00 41.17 O ATOM 431 N GLY A 59 −2.574 19.543 −9.521 1.00 43.33 N ATOM 432 CA GLY A 59 −1.271 19.082 −9.879 1.00 42.99 C ATOM 433 C GLY A 59 −1.419 18.194 −11.069 1.00 42.48 C ATOM 434 O GLY A 59 −2.458 17.537 −11.226 1.00 46.28 O ATOM 435 N LYS A 60 −0.380 18.196 −11.905 1.00 41.06 N ATOM 436 CA LYS A 60 −0.159 17.192 −12.969 1.00 38.02 C ATOM 437 CB LYS A 60 0.693 17.785 −14.129 1.00 39.06 C ATOM 438 CG LYS A 60 −0.081 18.804 −14.991 1.00 42.64 C ATOM 439 CD LYS A 60 0.721 19.595 −16.015 1.00 43.37 C ATOM 440 CE LYS A 60 1.277 18.673 −17.071 1.00 45.61 C ATOM 441 NZ LYS A 60 0.218 18.058 −17.914 1.00 47.23 N ATOM 442 C LYS A 60 0.535 15.952 −12.390 1.00 35.34 C ATOM 443 O LYS A 60 1.707 15.979 −12.090 1.00 30.00 O ATOM 444 N ILE A 61 −0.180 14.852 −12.247 1.00 36.68 N ATOM 445 CA ILE A 61 0.469 13.650 −11.726 1.00 39.94 C ATOM 446 CB ILE A 61 −0.460 12.437 −11.705 1.00 40.19 C ATOM 447 CG1 ILE A 61 −1.564 12.643 −10.682 1.00 42.02 C ATOM 448 CD1 ILE A 61 −2.739 11.747 −10.940 1.00 45.07 C ATOM 449 CG2 ILE A 61 0.317 11.218 −11.253 1.00 40.57 C ATOM 450 C ILE A 61 1.649 13.268 −12.574 1.00 40.25 C ATOM 451 O ILE A 61 1.451 13.026 −13.698 1.00 40.97 O ATOM 452 N ALA A 62 2.854 13.200 −12.029 1.00 43.18 N ATOM 453 CA ALA A 62 4.078 12.866 −12.821 1.00 43.52 C ATOM 454 CB ALA A 62 5.054 14.031 −12.778 1.00 42.94 C ATOM 455 C ALA A 62 4.795 11.572 −12.360 1.00 43.09 C ATOM 456 O ALA A 62 5.452 10.931 −13.134 1.00 50.11 O ATOM 457 N VAL A 63 4.717 11.238 −11.092 1.00 42.12 N ATOM 458 CA VAL A 63 5.059 9.926 −10.558 1.00 40.46 C ATOM 459 CB VAL A 63 6.220 10.039 −9.562 1.00 39.90 C ATOM 460 CG1 VAL A 63 6.772 8.692 −9.232 1.00 40.37 C ATOM 461 CG2 VAL A 63 7.346 10.867 −10.131 1.00 41.18 C ATOM 462 C VAL A 63 3.840 9.384 −9.786 1.00 42.70 C ATOM 463 O VAL A 63 3.113 10.105 −9.064 1.00 42.57 O ATOM 464 N MET A 64 3.628 8.094 −9.907 1.00 45.17 N ATOM 465 CA MET A 64 2.542 7.463 −9.182 1.00 46.69 C ATOM 466 CB MET A 64 1.297 7.427 −10.048 1.00 46.50 C ATOM 467 CG MET A 64 0.245 6.497 −9.510 1.00 47.97 C ATOM 468 SD MET A 64 −1.340 6.924 −10.164 1.00 53.90 S ATOM 469 CE MET A 64 −1.281 5.954 −11.669 1.00 55.11 C ATOM 470 C MET A 64 2.943 6.055 −8.825 1.00 46.95 C ATOM 471 O MET A 64 2.932 5.204 −9.713 1.00 51.01 O ATOM 472 N GLU A 65 3.285 5.800 −7.568 1.00 45.00 N ATOM 473 CA GLU A 65 3.741 4.471 −7.210 1.00 51.09 C ATOM 474 CB GLU A 65 5.272 4.446 −7.072 1.00 58.26 C ATOM 475 CG GLU A 65 6.052 4.774 −8.359 1.00 61.79 C ATOM 476 CD GLU A 65 5.847 3.744 −9.459 1.00 68.45 C ATOM 477 OE1 GLU A 65 5.349 2.601 −9.164 1.00 68.61 O ATOM 478 OE2 GLU A 65 6.181 4.097 −10.622 1.00 75.47 O ATOM 479 C GLU A 65 3.137 3.988 −5.943 1.00 47.13 C ATOM 480 O GLU A 65 3.046 4.755 −5.020 1.00 48.02 O ATOM 481 N LEU A 66 2.764 2.708 −5.896 1.00 46.57 N ATOM 482 CA LEU A 66 2.233 2.084 −4.670 1.00 46.42 C ATOM 483 CB LEU A 66 1.148 1.073 −4.982 1.00 42.76 C ATOM 484 CG LEU A 66 −0.251 1.666 −5.184 1.00 41.69 C ATOM 485 CD1 LEU A 66 −1.139 0.535 −5.691 1.00 41.51 C ATOM 486 CD2 LEU A 66 −0.881 2.320 −3.940 1.00 40.68 C ATOM 487 C LEU A 66 3.332 1.411 −3.870 1.00 49.67 C ATOM 488 O LEU A 66 4.264 0.875 −4.431 1.00 54.17 O ATOM 489 N PHE A 67 3.232 1.470 −2.555 1.00 53.28 N ATOM 490 CA PHE A 67 4.234 0.863 −1.678 1.00 57.57 C ATOM 491 CB PHE A 67 5.455 1.787 −1.521 1.00 53.47 C ATOM 492 CG PHE A 67 5.187 2.978 −0.690 1.00 54.40 C ATOM 493 CD1 PHE A 67 4.447 4.030 −1.189 1.00 54.73 C ATOM 494 CE1 PHE A 67 4.166 5.143 −0.393 1.00 55.50 C ATOM 495 CZ PHE A 67 4.623 5.206 0.911 1.00 52.99 C ATOM 496 CE2 PHE A 67 5.342 4.138 1.424 1.00 54.32 C ATOM 497 CD2 PHE A 67 5.614 3.033 0.630 1.00 55.90 C ATOM 498 C PHE A 67 3.580 0.506 −0.337 1.00 64.11 C ATOM 499 O PHE A 67 2.493 1.003 −0.029 1.00 70.80 O ATOM 500 N ARG A 68 4.213 −0.382 0.429 1.00 70.32 N ATOM 501 CA ARG A 68 3.699 −0.806 1.747 1.00 73.36 C ATOM 502 CB ARG A 68 3.125 −2.233 1.701 1.00 69.89 C ATOM 503 CG ARG A 68 1.896 −2.352 2.552 1.00 70.81 C ATOM 504 CD ARG A 68 1.497 −3.783 2.837 1.00 75.39 C ATOM 505 NE ARG A 68 0.436 −4.272 1.952 1.00 75.87 N ATOM 506 CZ ARG A 68 −0.332 −5.333 2.203 1.00 81.34 C ATOM 507 NH1 ARG A 68 −0.198 −6.025 3.340 1.00 89.34 N ATOM 508 NH2 ARG A 68 −1.258 −5.715 1.321 1.00 83.00 N ATOM 509 C ARG A 68 4.846 −0.740 2.743 1.00 79.30 C ATOM 510 O ARG A 68 5.662 −1.645 2.765 1.00 77.42 O ATOM 511 N PRO A 69 4.929 0.336 3.559 1.00 88.44 N ATOM 512 CA PRO A 69 6.031 0.347 4.527 1.00 91.63 C ATOM 513 CB PRO A 69 6.054 1.795 5.033 1.00 92.01 C ATOM 514 CG PRO A 69 4.653 2.281 4.851 1.00 92.58 C ATOM 515 CD PRO A 69 4.023 1.487 3.735 1.00 89.40 C ATOM 516 C PRO A 69 5.773 −0.683 5.648 1.00 95.91 C ATOM 517 O PRO A 69 4.626 −1.172 5.800 1.00 90.29 O ATOM 518 N LYS A 70 6.832 −1.012 6.400 1.00 94.87 N ATOM 519 CA LYS A 70 6.796 −2.148 7.310 1.00 93.51 C ATOM 520 CB LYS A 70 8.117 −2.328 8.047 1.00 101.05 C ATOM 521 CG LYS A 70 8.349 −3.777 8.490 1.00 108.47 C ATOM 522 CD LYS A 70 9.128 −4.606 7.458 1.00 113.18 C ATOM 523 CE LYS A 70 10.492 −4.005 7.065 1.00 112.45 C ATOM 524 NZ LYS A 70 11.216 −3.227 8.130 1.00 108.58 N ATOM 525 C LYS A 70 5.707 −1.904 8.308 1.00 84.14 C ATOM 526 O LYS A 70 5.696 −0.834 8.925 1.00 73.15 O ATOM 527 N GLY A 71 4.786 −2.868 8.418 1.00 80.46 N ATOM 528 CA GLY A 71 3.658 −2.781 9.356 1.00 85.28 C ATOM 529 C GLY A 71 2.569 −1.757 8.999 1.00 88.33 C ATOM 530 O GLY A 71 2.281 −0.797 9.742 1.00 83.75 O ATOM 531 N GLU A 72 1.971 −1.963 7.833 1.00 85.73 N ATOM 532 CA GLU A 72 0.797 −1.232 7.418 1.00 74.93 C ATOM 533 CB GLU A 72 1.186 −0.169 6.401 1.00 80.05 C ATOM 534 CG GLU A 72 0.200 1.009 6.333 1.00 82.89 C ATOM 535 CD GLU A 72 0.618 2.200 7.188 1.00 78.44 C ATOM 536 OE1 GLU A 72 −0.252 3.031 7.501 1.00 71.65 O ATOM 537 OE2 GLU A 72 1.812 2.336 7.537 1.00 75.09 O ATOM 538 C GLU A 72 −0.152 −2.261 6.814 1.00 67.28 C ATOM 539 O GLU A 72 0.251 −3.144 6.049 1.00 63.08 O ATOM 540 N SER A 73 −1.417 −2.176 7.176 1.00 65.73 N ATOM 541 CA SER A 73 −2.366 −3.210 6.777 1.00 65.10 C ATOM 542 CB SER A 73 −3.763 −2.962 7.381 1.00 63.49 C ATOM 543 OG SER A 73 −4.375 −1.772 6.913 1.00 62.76 O ATOM 544 C SER A 73 −2.408 −3.324 5.266 1.00 66.51 C ATOM 545 O SER A 73 −2.382 −4.435 4.751 1.00 67.26 O ATOM 546 N LYS A 74 −2.372 −2.162 4.595 1.00 68.69 N ATOM 547 CA LYS A 74 −2.539 −2.026 3.150 1.00 69.16 C ATOM 548 CB LYS A 74 −3.974 −1.582 2.841 1.00 71.88 C ATOM 549 CG LYS A 74 −4.421 −0.331 3.572 1.00 75.71 C ATOM 550 CD LYS A 74 −5.870 0.008 3.241 1.00 76.35 C ATOM 551 CE LYS A 74 −6.317 1.175 4.098 1.00 79.39 C ATOM 552 NZ LYS A 74 −7.777 1.077 4.316 1.00 83.89 N ATOM 553 C LYS A 74 −1.517 −1.051 2.543 1.00 66.10 C ATOM 554 O LYS A 74 −0.760 −0.443 3.304 1.00 65.87 O ATOM 555 N ASP A 75 −1.501 −0.930 1.192 1.00 61.66 N ATOM 556 CA ASP A 75 −0.564 −0.058 0.450 1.00 57.96 C ATOM 557 CB ASP A 75 −0.405 −0.397 −1.050 1.00 60.78 C ATOM 558 CG ASP A 75 0.112 −1.839 −1.358 1.00 63.67 C ATOM 559 OD1 ASP A 75 0.624 −2.548 −0.466 1.00 71.08 O ATOM 560 OD2 ASP A 75 0.025 −2.248 −2.561 1.00 63.14 O ATOM 561 C ASP A 75 −0.961 1.430 0.506 1.00 56.34 C ATOM 562 O ASP A 75 −2.155 1.819 0.631 1.00 55.47 O ATOM 563 N LEU A 76 0.080 2.248 0.424 1.00 52.98 N ATOM 564 CA LEU A 76 −0.029 3.681 0.368 1.00 52.58 C ATOM 565 CB LEU A 76 0.851 4.382 1.409 1.00 52.31 C ATOM 566 CG LEU A 76 0.615 4.107 2.894 1.00 50.59 C ATOM 567 CD1 LEU A 76 1.521 4.971 3.783 1.00 49.79 C ATOM 568 CD2 LEU A 76 −0.838 4.368 3.181 1.00 50.85 C ATOM 569 C LEU A 76 0.499 4.049 −0.977 1.00 52.74 C ATOM 570 O LEU A 76 1.319 3.318 −1.562 1.00 49.73 O ATOM 571 N LEU A 77 0.063 5.223 −1.423 1.00 50.81 N ATOM 572 CA LEU A 77 0.317 5.693 −2.765 1.00 46.41 C ATOM 573 CB LEU A 77 −1.025 6.068 −3.375 1.00 42.83 C ATOM 574 CG LEU A 77 −0.975 6.668 −4.761 1.00 41.39 C ATOM 575 CD1 LEU A 77 −0.340 5.706 −5.712 1.00 40.64 C ATOM 576 CD2 LEU A 77 −2.377 7.009 −5.213 1.00 42.14 C ATOM 577 C LEU A 77 1.277 6.877 −2.693 1.00 46.13 C ATOM 578 O LEU A 77 1.040 7.809 −1.949 1.00 48.37 O ATOM 579 N PHE A 78 2.385 6.825 −3.412 1.00 46.03 N ATOM 580 CA PHE A 78 3.219 8.010 −3.563 1.00 48.98 C ATOM 581 CB PHE A 78 4.684 7.669 −3.614 1.00 49.04 C ATOM 582 CG PHE A 78 5.564 8.852 −3.848 1.00 47.89 C ATOM 583 CD1 PHE A 78 5.640 9.839 −2.930 1.00 48.10 C ATOM 584 CE1 PHE A 78 6.454 10.925 −3.123 1.00 50.75 C ATOM 585 CE PHE A 78 7.227 11.022 −4.256 1.00 52.95 C ATOM 586 CE2 PHE A 78 7.170 10.024 −5.186 1.00 52.94 C ATOM 587 CD2 PHE A 78 6.324 8.947 −4.980 1.00 51.27 C ATOM 588 C PHE A 78 2.893 8.693 −4.857 1.00 49.56 C ATOM 589 O PHE A 78 2.834 8.018 −5.870 1.00 52.68 O ATOM 590 N ILE A 79 2.755 10.018 −4.824 1.00 47.61 N ATOM 591 CA ILE A 79 2.542 10.778 −6.027 1.00 48.61 C ATOM 592 CB ILE A 79 1.055 11.144 −6.175 1.00 49.48 C ATOM 593 CG1 ILE A 79 0.317 9.932 −6.744 1.00 48.54 C ATOM 594 CD1 ILE A 79 −1.106 10.229 −7.140 1.00 49.32 C ATOM 595 CG2 ILE A 79 0.823 12.439 −6.996 1.00 48.93 C ATOM 596 C ILE A 79 3.387 12.001 −5.985 1.00 48.96 C ATOM 597 O ILE A 79 3.487 12.660 −4.943 1.00 55.42 O ATOM 598 N LEU A 80 3.970 12.325 −7.125 1.00 45.74 N ATOM 599 CA LEU A 80 4.684 13.583 −7.263 1.00 44.77 C ATOM 600 CB LEU A 80 6.156 13.297 −7.536 1.00 46.90 C ATOM 601 CG LEU A 80 7.053 14.517 −7.731 1.00 46.50 C ATOM 602 CD1 LEU A 80 6.983 15.454 −6.532 1.00 46.17 C ATOM 603 CD2 LEU A 80 8.469 14.044 −7.971 1.00 45.49 C ATOM 604 C LEU A 80 4.127 14.332 −8.429 1.00 39.83 C ATOM 605 O LEU A 80 4.019 13.763 −9.509 1.00 33.78 O ATOM 606 N THR A 81 3.815 15.604 −8.252 1.00 38.58 N ATOM 607 CA THR A 81 3.324 16.363 −9.416 1.00 42.56 C ATOM 608 CB THR A 81 2.413 17.517 −9.095 1.00 39.67 C ATOM 609 OG1 THR A 81 3.238 18.519 −8.509 1.00 42.48 O ATOM 610 CG2 THR A 81 1.324 17.073 −8.221 1.00 39.53 C ATOM 611 C THR A 81 4.465 17.013 −10.189 1.00 43.50 C ATOM 612 O THR A 81 5.603 16.938 −9.778 1.00 44.79 O ATOM 613 N ALA A 82 4.111 17.678 −11.286 1.00 42.70 N ATOM 614 CA ALA A 82 5.048 18.416 −12.090 1.00 42.67 C ATOM 615 CB ALA A 82 4.460 18.786 −13.435 1.00 42.68 C ATOM 616 C ALA A 82 5.546 19.647 −11.412 1.00 40.95 C ATOM 617 O ALA A 82 6.643 20.059 −11.692 1.00 44.78 O ATOM 618 N LYS A 83 4.797 20.246 −10.521 1.00 39.76 N ATOM 619 CA LYS A 83 5.407 21.360 −9.770 1.00 40.13 C ATOM 620 CB LYS A 83 4.384 22.426 −9.430 1.00 37.50 C ATOM 621 CG LYS A 83 3.971 23.205 −10.619 1.00 35.06 C ATOM 622 CD LYS A 83 2.843 24.098 −10.237 1.00 36.05 C ATOM 623 CE LYS A 83 2.259 24.679 −11.509 1.00 39.90 C ATOM 624 NZ LYS A 83 1.616 26.040 −11.417 1.00 43.43 N ATOM 625 C LYS A 83 6.189 20.930 −8.525 1.00 42.19 C ATOM 626 O LYS A 83 6.609 21.775 −7.722 1.00 43.28 O ATOM 627 N TYR A 84 6.431 19.626 −8.408 1.00 44.89 N ATOM 628 CA TYR A 84 7.270 19.034 −7.354 1.00 45.59 C ATOM 629 CB TYR A 84 8.685 19.669 −7.273 1.00 45.95 C ATOM 630 CG TYR A 84 9.437 19.780 −8.627 1.00 47.28 C ATOM 631 CD1 TYR A 84 10.181 18.719 −9.102 1.00 47.85 C ATOM 632 CE1 TYR A 84 10.863 18.798 −10.295 1.00 49.95 C ATOM 633 CZ TYR A 84 10.837 19.953 −11.032 1.00 49.71 C ATOM 634 OH TYR A 84 11.537 19.930 −12.203 1.00 56.17 O ATOM 635 CE2 TYR A 84 10.137 21.048 −10.598 1.00 45.99 C ATOM 636 CD2 TYR A 84 9.439 20.963 −9.391 1.00 46.69 C ATOM 637 C TYR A 84 6.520 18.993 −6.017 1.00 45.78 C ATOM 638 O TYR A 84 7.123 18.950 −4.985 1.00 42.36 O ATOM 639 N ASN A 85 5.188 18.940 −6.093 1.00 49.82 N ATOM 640 CA ASN A 85 4.303 18.491 −4.994 1.00 50.13 C ATOM 641 CB ASN A 85 2.845 18.774 −5.373 1.00 48.18 C ATOM 642 CG ASN A 85 2.591 20.257 −5.599 1.00 51.30 C ATOM 643 OD1 ASN A 85 2.227 20.704 −6.701 1.00 50.99 O ATOM 644 ND2 ASN A 85 2.839 21.046 −4.552 1.00 52.99 N ATOM 645 C ASN A 85 4.437 16.999 −4.701 1.00 52.15 C ATOM 646 O ASN A 85 4.003 16.157 −5.488 1.00 57.59 O ATOM 647 N ALA A 86 5.055 16.647 −3.589 1.00 54.10 N ATOM 648 CA ALA A 86 5.056 15.236 −3.153 1.00 54.19 C ATOM 649 CB ALA A 86 6.375 14.881 −2.526 1.00 57.12 C ATOM 650 C ALA A 86 3.997 15.012 −2.146 1.00 48.88 C ATOM 651 O ALA A 86 3.815 15.843 −1.267 1.00 47.17 O ATOM 652 N CYS A 87 3.299 13.899 −2.272 1.00 47.72 N ATOM 653 CA CYS A 87 2.447 13.434 −1.181 1.00 48.95 C ATOM 654 CB CYS A 87 0.988 13.818 −1.396 1.00 49.03 C ATOM 655 SG CYS A 87 0.272 13.417 −2.989 1.00 48.82 S ATOM 656 C CYS A 87 2.509 11.966 −1.033 1.00 47.37 C ATOM 657 O CYS A 87 2.817 11.307 −2.005 1.00 51.39 O ATOM 658 N ILE A 88 2.208 11.481 0.175 1.00 44.32 N ATOM 659 CA ILE A 88 1.857 10.089 0.437 1.00 43.69 C ATOM 660 CB ILE A 88 2.671 9.513 1.577 1.00 45.16 C ATOM 661 CG1 ILE A 88 4.102 9.260 1.075 1.00 46.07 C ATOM 662 CD1 ILE A 88 5.088 8.765 2.110 1.00 44.30 C ATOM 663 CG2 ILE A 88 2.053 8.206 2.051 1.00 47.69 C ATOM 664 C ILE A 88 0.398 9.999 0.819 1.00 45.27 C ATOM 665 O ILE A 88 −0.059 10.740 1.654 1.00 46.70 O ATOM 666 N LEU A 89 −0.342 9.077 0.223 1.00 48.45 N ATOM 667 CA LEU A 89 −1.798 9.103 0.324 1.00 49.79 C ATOM 668 CB LEU A 89 −2.448 9.418 −1.033 1.00 52.39 C ATOM 669 CG LEU A 89 −2.180 10.741 −1.750 1.00 56.42 C ATOM 670 CD1 LEU A 89 −2.961 10.849 −3.049 1.00 60.31 C ATOM 671 CD2 LEU A 89 −2.552 11.917 −0.885 1.00 58.04 C ATOM 672 C LEU A 89 −2.271 7.757 0.777 1.00 49.38 C ATOM 673 O LEU A 89 −1.640 6.756 0.451 1.00 48.59 O ATOM 674 N GLU A 90 −3.406 7.763 1.481 1.00 50.90 N ATOM 675 CA GLU A 90 −4.106 6.575 1.945 1.00 55.01 C ATOM 676 CB GLU A 90 −3.830 6.418 3.417 1.00 62.32 C ATOM 677 CG GLU A 90 −4.501 5.213 4.056 1.00 69.81 C ATOM 678 CD GLU A 90 −4.412 5.226 5.567 1.00 76.00 C ATOM 679 OE1 GLU A 90 −3.896 6.234 6.167 1.00 73.83 O ATOM 680 OE2 GLU A 90 −4.883 4.200 6.124 1.00 81.57 O ATOM 681 C GLU A 90 −5.640 6.616 1.753 1.00 55.70 C ATOM 682 O GLU A 90 −6.304 7.663 1.934 1.00 53.95 O ATOM 683 N TYR A 91 −6.194 5.440 1.461 1.00 56.54 N ATOM 684 CA TYR A 91 −7.625 5.264 1.194 1.00 57.20 C ATOM 685 CB TYR A 91 −7.793 4.036 0.314 1.00 55.59 C ATOM 686 CG TYR A 91 −9.136 3.780 −0.270 1.00 52.74 C ATOM 687 CD1 TYR A 91 −9.513 4.297 −1.485 1.00 56.14 C ATOM 688 CE1 TYR A 91 −10.757 4.014 −2.030 1.00 57.78 C ATOM 689 CZ TYR A 91 −11.612 3.182 −1.350 1.00 57.30 C ATOM 690 OH TYR A 91 −12.868 2.816 −1.781 1.00 57.05 O ATOM 691 CE2 TYR A 91 −11.234 2.676 −0.154 1.00 58.23 C ATOM 692 CD2 TYR A 91 −9.992 2.962 0.358 1.00 56.06 C ATOM 693 C TYR A 91 −8.379 5.077 2.504 1.00 58.02 C ATOM 694 O TYR A 91 −8.043 4.221 3.273 1.00 57.15 O ATOM 695 N LYS A 92 −9.404 5.881 2.737 1.00 61.56 N ATOM 696 CA LYS A 92 −10.154 5.845 3.959 1.00 65.18 C ATOM 697 CB LYS A 92 −9.854 7.098 4.762 1.00 68.82 C ATOM 698 CG LYS A 92 −8.933 6.820 5.914 1.00 78.32 C ATOM 699 CD LYS A 92 −9.614 6.028 7.039 1.00 82.94 C ATOM 700 CE LYS A 92 −8.880 6.244 8.374 1.00 87.48 C ATOM 701 NZ LYS A 92 −7.406 5.980 8.282 1.00 85.82 N ATOM 702 C LYS A 92 −11.655 5.704 3.732 1.00 68.50 C ATOM 703 O LYS A 92 −12.361 6.683 3.458 1.00 64.60 O ATOM 704 N GLN A 93 −12.152 4.478 3.893 1.00 71.90 N ATOM 705 CA GLN A 93 −13.582 4.269 4.019 1.00 72.73 C ATOM 706 CB GLN A 93 −13.928 2.871 3.626 1.00 78.18 C ATOM 707 CG GLN A 93 −15.408 2.657 3.425 1.00 80.21 C ATOM 708 CD GLN A 93 −15.666 2.077 2.063 1.00 86.46 C ATOM 709 OE1 GLN A 93 −14.803 1.377 1.486 1.00 87.95 O ATOM 710 NE2 GLN A 93 −16.843 2.387 1.510 1.00 89.41 N ATOM 711 C GLN A 93 −13.962 4.481 5.464 1.00 76.38 C ATOM 712 O GLN A 93 −13.467 3.778 6.354 1.00 81.86 O ATOM 713 N SER A 94 −14.774 5.503 5.699 1.00 75.75 N ATOM 714 CA SER A 94 −15.346 5.789 7.005 1.00 69.58 C ATOM 715 CB SER A 94 −14.888 7.162 7.525 1.00 61.42 C ATOM 716 C SER A 94 −16.855 5.668 6.708 1.00 71.86 C ATOM 717 O SER A 94 −17.498 6.562 6.148 1.00 69.43 O ATOM 718 N GLY A 95 −17.384 4.484 6.988 1.00 77.84 N ATOM 719 CA GLY A 95 −18.811 4.217 6.887 1.00 77.67 C ATOM 720 C GLY A 95 −19.220 3.923 5.478 1.00 77.11 C ATOM 721 O GLY A 95 −18.718 2.978 4.883 1.00 79.28 O ATOM 722 N GLU A 96 −20.143 4.729 4.958 1.00 79.14 N ATOM 723 CA GLU A 96 −20.588 4.641 3.557 1.00 81.46 C ATOM 724 CB GLU A 96 −22.142 4.585 3.456 1.00 79.12 C ATOM 725 C GLU A 96 −19.985 5.811 2.730 1.00 74.77 C ATOM 726 O GLU A 96 −20.496 6.144 1.673 1.00 74.22 O ATOM 727 N SER A 97 −18.893 6.417 3.198 1.00 69.03 N ATOM 728 CA SER A 97 −18.185 7.392 2.385 1.00 67.90 C ATOM 729 CB SER A 97 −18.542 8.825 2.820 1.00 63.74 C ATOM 730 OG SER A 97 −17.968 9.119 4.041 1.00 56.82 O ATOM 731 C SER A 97 −16.661 7.094 2.311 1.00 68.17 C ATOM 732 O SER A 97 −16.069 6.515 3.220 1.00 72.32 O ATOM 733 N ILE A 98 −16.070 7.474 1.181 1.00 67.05 N ATOM 734 CA ILE A 98 −14.742 7.045 0.742 1.00 64.47 C ATOM 735 CB ILE A 98 −14.809 6.382 −0.672 1.00 66.14 C ATOM 736 CG1 ILE A 98 −15.917 5.328 −0.766 1.00 69.43 C ATOM 737 CD1 ILE A 98 −17.252 5.863 −1.310 1.00 78.70 C ATOM 738 CG2 ILE A 98 −13.476 5.790 −1.082 1.00 66.43 C ATOM 739 C ILE A 98 −13.926 8.332 0.634 1.00 62.10 C ATOM 740 O ILE A 98 −14.454 9.325 0.137 1.00 67.96 O ATOM 741 N ASP A 99 −12.655 8.304 1.046 1.00 58.38 N ATOM 742 CA ASP A 99 −11.805 9.508 1.164 1.00 58.36 C ATOM 743 CB ASP A 99 −12.025 10.206 2.521 1.00 61.67 C ATOM 744 CG ASP A 99 −13.153 11.232 2.504 1.00 64.23 C ATOM 745 OD1 ASP A 99 −13.754 11.569 1.458 1.00 67.72 O ATOM 746 OD2 ASP A 99 −13.424 11.747 3.588 1.00 76.12 O ATOM 747 C ASP A 99 −10.317 9.222 1.058 1.00 56.57 C ATOM 748 O ASP A 99 −9.834 8.240 1.589 1.00 61.19 O ATOM 749 N ILE A 100 −9.579 10.117 0.414 1.00 56.01 N ATOM 750 CA ILE A 100 −8.159 9.920 0.206 1.00 53.27 C ATOM 751 CB ILE A 100 −7.806 9.984 −1.284 1.00 52.13 C ATOM 752 CG1 ILE A 100 −8.906 9.247 −2.066 1.00 52.79 C ATOM 753 CD1 ILE A 100 −8.436 8.369 −3.181 1.00 56.05 C ATOM 754 CG2 ILE A 100 −6.368 9.490 −1.508 1.00 49.37 C ATOM 755 C ILE A 100 −7.438 10.970 1.034 1.00 53.05 C ATOM 756 O ILE A 100 −7.420 12.178 0.728 1.00 53.89 O ATOM 757 N ILE A 101 −6.839 10.479 2.096 1.00 51.06 N ATOM 758 CA ILE A 101 −6.298 11.334 3.111 1.00 53.96 C ATOM 759 CB ILE A 101 −6.697 10.851 4.532 1.00 56.54 C ATOM 760 CG1 ILE A 101 −6.069 9.488 4.854 1.00 59.52 C ATOM 761 CD1 ILE A 101 −6.137 9.078 6.291 1.00 61.61 C ATOM 762 CG2 ILE A 101 −8.212 10.708 4.637 1.00 56.65 C ATOM 763 C ILE A 101 −4.804 11.327 2.888 1.00 53.61 C ATOM 764 O ILE A 101 −4.240 10.370 2.355 1.00 51.73 O ATOM 765 N THR A 102 −4.169 12.384 3.362 1.00 54.11 N ATOM 766 CA THR A 102 −2.801 12.697 3.039 1.00 49.59 C ATOM 767 CB THR A 102 −2.745 14.171 2.662 1.00 49.20 C ATOM 768 OG1 THR A 102 −3.700 14.434 1.623 1.00 51.50 O ATOM 769 CG2 THR A 102 −1.392 14.559 2.221 1.00 51.05 C ATOM 770 C THR A 102 −1.982 12.451 4.272 1.00 49.45 C ATOM 771 O THR A 102 −1.980 13.257 5.206 1.00 55.36 O ATOM 772 N ARG A 103 −1.310 11.323 4.294 1.00 47.26 N ATOM 773 CA ARG A 103 −0.372 11.012 5.352 1.00 48.19 C ATOM 774 CB ARG A 103 0.096 9.575 5.202 1.00 49.65 C ATOM 775 CG ARG A 103 −1.021 8.578 5.487 1.00 53.14 C ATOM 776 CD ARG A 103 −1.148 8.307 6.981 1.00 52.54 C ATOM 777 NE ARG A 103 −0.039 7.446 7.366 1.00 50.53 N ATOM 778 CZ ARG A 103 −0.032 6.121 7.236 1.00 50.77 C ATOM 779 NH1 ARG A 103 −1.087 5.446 6.764 1.00 49.86 N ATOM 780 NH2 ARG A 103 1.042 5.452 7.605 1.00 52.24 N ATOM 781 C ARG A 103 0.877 11.892 5.411 1.00 50.86 C ATOM 782 O ARG A 103 1.504 11.969 6.450 1.00 61.85 O ATOM 783 N ALA A 104 1.281 12.517 4.314 1.00 48.97 N ATOM 784 CA ALA A 104 2.528 13.282 4.262 1.00 45.79 C ATOM 785 CB ALA A 104 3.737 12.362 4.262 1.00 43.83 C ATOM 786 C ALA A 104 2.536 14.121 3.008 1.00 46.52 C ATOM 787 O ALA A 104 1.983 13.746 1.992 1.00 42.88 O ATOM 788 N HIS A 105 3.171 15.272 3.063 1.00 49.70 N ATOM 789 CA HIS A 105 3.251 16.073 1.869 1.00 50.89 C ATOM 790 CB HIS A 105 1.927 16.774 1.600 1.00 51.38 C ATOM 791 CG HIS A 105 1.692 17.913 2.523 1.00 53.93 C ATOM 792 ND1 HIS A 105 1.406 17.726 3.860 1.00 57.72 N ATOM 793 CE1 HIS A 105 1.313 18.900 4.452 1.00 56.98 C ATOM 794 NE2 HIS A 105 1.542 19.837 3.545 1.00 55.84 N ATOM 795 CD2 HIS A 105 1.806 19.246 2.339 1.00 51.71 C ATOM 796 C HIS A 105 4.303 17.112 2.040 1.00 48.43 C ATOM 797 O HIS A 105 4.422 17.700 3.099 1.00 50.73 O ATOM 798 N GLY A 106 5.048 17.346 0.978 1.00 47.91 N ATOM 799 CA GLY A 106 5.896 18.521 0.897 1.00 48.89 C ATOM 800 C GLY A 106 6.382 18.784 −0.509 1.00 47.17 C ATOM 801 O GLY A 106 6.326 17.891 −1.342 1.00 53.37 O ATOM 802 N ASN A 107 6.897 19.975 −0.763 1.00 43.94 N ATOM 803 CA ASN A 107 7.372 20.299 −2.079 1.00 47.06 C ATOM 804 CB ASN A 107 7.011 21.733 −2.434 1.00 50.09 C ATOM 805 CG ASN A 107 7.306 22.066 −3.866 1.00 53.77 C ATOM 806 OD1 ASN A 107 8.384 21.790 −4.361 1.00 58.13 O ATOM 807 ND2 ASN A 107 6.347 22.658 −4.543 1.00 59.29 N ATOM 808 C ASN A 107 8.864 20.059 −2.206 1.00 47.02 C ATOM 809 O ASN A 107 9.622 20.763 −1.608 1.00 51.85 O ATOM 810 N VAL A 108 9.285 19.148 −3.079 1.00 47.79 N ATOM 811 CA VAL A 108 10.669 18.666 −3.118 1.00 47.12 C ATOM 812 CB VAL A 108 10.703 17.165 −3.404 1.00 46.51 C ATOM 813 CG1 VAL A 108 9.798 16.445 −2.439 1.00 46.42 C ATOM 814 CG2 VAL A 108 10.226 16.848 −4.815 1.00 49.30 C ATOM 815 C VAL A 108 11.543 19.397 −4.112 1.00 51.22 C ATOM 816 O VAL A 108 12.609 18.917 −4.464 1.00 56.63 O ATOM 817 N GLN A 109 11.108 20.562 −4.559 1.00 53.35 N ATOM 818 CA GLN A 109 11.867 21.393 −5.490 1.00 58.39 C ATOM 819 CB GLN A 109 11.029 22.618 −5.682 1.00 62.94 C ATOM 820 CG GLN A 109 11.517 23.706 −6.577 1.00 68.36 C ATOM 821 CD GLN A 109 10.326 24.522 −7.025 1.00 75.56 C ATOM 822 OE1 GLN A 109 9.331 24.684 −6.285 1.00 78.20 O ATOM 823 NE2 GLN A 109 10.380 24.991 −8.256 1.00 79.30 N ATOM 824 C GLN A 109 13.197 21.828 −4.933 1.00 60.61 C ATOM 825 O GLN A 109 13.286 21.967 −3.743 1.00 61.78 O ATOM 826 N ASP A 110 14.217 22.033 −5.778 1.00 65.43 N ATOM 827 CA ASP A 110 15.471 22.784 −5.429 1.00 67.40 C ATOM 828 CB ASP A 110 16.701 21.965 −5.843 1.00 66.15 C ATOM 829 CG ASP A 110 16.847 20.693 −5.055 1.00 62.70 C ATOM 830 OD1 ASP A 110 16.405 20.706 −3.914 1.00 59.32 O ATOM 831 OD2 ASP A 110 17.411 19.681 −5.536 1.00 65.85 O ATOM 832 C ASP A 110 15.559 24.187 −6.106 1.00 71.79 C ATOM 833 O ASP A 110 15.330 24.282 −7.311 1.00 78.30 O ATOM 834 N ARG A 111 15.911 25.253 −5.363 1.00 76.56 N ATOM 835 CA ARG A 111 15.990 26.641 −5.934 1.00 76.01 C ATOM 836 CB ARG A 111 16.425 27.666 −4.858 1.00 68.40 C ATOM 837 C ARG A 111 16.909 26.713 −7.204 1.00 79.48 C ATOM 838 O ARG A 111 16.474 27.169 −8.262 1.00 80.60 O ATOM 839 N ILE A 112 18.155 26.241 −7.073 1.00 79.58 N ATOM 840 CA ILE A 112 19.124 26.124 −8.157 1.00 75.26 C ATOM 841 CB ILE A 112 20.554 26.568 −7.666 1.00 61.20 C ATOM 842 C ILE A 112 19.048 24.637 −8.651 1.00 82.82 C ATOM 843 O ILE A 112 19.347 23.684 −7.882 1.00 90.40 O ATOM 844 N GLY A 113 18.595 24.440 −9.904 1.00 82.38 N ATOM 845 CA GLY A 113 18.653 23.113 −10.614 1.00 78.36 C ATOM 846 C GLY A 113 18.242 23.084 −12.118 1.00 77.60 C ATOM 847 O GLY A 113 17.204 23.676 −12.507 1.00 68.87 O ATOM 848 N ARG A 114 19.041 22.403 −12.973 1.00 77.96 N ATOM 849 CA ARG A 114 18.672 22.159 −14.417 1.00 78.28 C ATOM 850 CB ARG A 114 19.879 22.129 −15.404 1.00 73.48 C ATOM 851 C ARG A 114 17.877 20.840 −14.484 1.00 75.49 C ATOM 852 O ARG A 114 18.418 19.767 −14.168 1.00 79.51 O ATOM 853 N PRO A 115 16.581 20.911 −14.859 1.00 69.41 N ATOM 854 CA PRO A 115 15.778 19.667 −14.837 1.00 62.52 C ATOM 855 CB PRO A 115 14.359 20.153 −15.120 1.00 61.34 C ATOM 856 CG PRO A 115 14.390 21.649 −14.989 1.00 63.02 C ATOM 857 CD PRO A 115 15.785 22.082 −15.280 1.00 65.33 C ATOM 858 C PRO A 115 16.236 18.719 −15.907 1.00 56.91 C ATOM 859 O PRO A 115 16.488 19.151 −17.023 1.00 54.46 O ATOM 860 N SER A 116 16.363 17.455 −15.569 1.00 55.96 N ATOM 861 CA SER A 116 17.001 16.500 −16.471 1.00 66.16 C ATOM 862 CB SER A 116 17.128 15.158 −15.783 1.00 70.10 C ATOM 863 OG SER A 116 17.654 15.346 −14.490 1.00 76.88 O ATOM 864 C SER A 116 16.291 16.271 −17.795 1.00 70.62 C ATOM 865 O SER A 116 15.078 16.373 −17.861 1.00 76.73 O ATOM 866 N GLU A 117 17.043 15.907 −18.832 1.00 74.86 N ATOM 867 CA GLU A 117 16.471 15.733 −20.172 1.00 75.45 C ATOM 868 CB GLU A 117 17.540 15.693 −21.272 1.00 82.27 C ATOM 869 CG GLU A 117 18.069 17.049 −21.734 1.00 88.29 C ATOM 870 CD GLU A 117 19.143 16.929 −22.817 1.00 94.14 C ATOM 871 OE1 GLU A 117 20.074 17.761 −22.858 1.00 99.09 O ATOM 872 OE2 GLU A 117 19.069 15.996 −23.638 1.00 101.87 O ATOM 873 C GLU A 117 15.632 14.502 −20.284 1.00 72.06 C ATOM 874 O GLU A 117 14.887 14.397 −21.237 1.00 80.37 O ATOM 875 N THR A 118 15.756 13.560 −19.356 1.00 72.67 N ATOM 876 CA THR A 118 14.833 12.403 −19.299 1.00 75.68 C ATOM 877 CB THR A 118 15.602 11.129 −18.969 1.00 78.26 C ATOM 878 OG1 THR A 118 16.965 11.336 −19.322 1.00 80.04 O ATOM 879 CG2 THR A 118 15.054 9.959 −19.735 1.00 83.14 C ATOM 880 C THR A 118 13.672 12.588 −18.296 1.00 70.30 C ATOM 881 O THR A 118 12.984 11.651 −17.863 1.00 63.75 O ATOM 882 N GLY A 119 13.448 13.830 −17.940 1.00 71.53 N ATOM 883 CA GLY A 119 12.362 14.168 −17.070 1.00 73.84 C ATOM 884 C GLY A 119 12.481 13.665 −15.653 1.00 67.38 C ATOM 885 O GLY A 119 13.512 13.155 −15.226 1.00 70.63 O ATOM 886 N ILE A 120 11.367 13.812 −14.954 1.00 61.25 N ATOM 887 CA ILE A 120 11.229 13.393 −13.594 1.00 54.05 C ATOM 888 CB ILE A 120 9.865 13.801 −13.059 1.00 52.55 C ATOM 889 CG1 ILE A 120 9.685 15.332 −13.239 1.00 55.14 C ATOM 890 CD1 ILE A 120 9.354 16.188 −12.010 1.00 56.56 C ATOM 891 CG2 ILE A 120 9.711 13.266 −11.650 1.00 51.99 C ATOM 892 C ILE A 120 11.282 11.910 −13.633 1.00 50.93 C ATOM 893 O ILE A 120 10.658 11.353 −14.477 1.00 50.42 O ATOM 894 N ILE A 121 12.064 11.284 −12.770 1.00 49.35 N ATOM 895 CA ILE A 121 11.943 9.856 −12.538 1.00 52.07 C ATOM 896 CB ILE A 121 13.172 9.089 −13.003 1.00 53.29 C ATOM 897 CG1 ILE A 121 13.182 9.041 −14.534 1.00 54.83 C ATOM 898 CD1 ILE A 121 14.529 8.705 −15.121 1.00 55.63 C ATOM 899 CG2 ILE A 121 13.203 7.689 −12.397 1.00 51.51 C ATOM 900 C ILE A 121 11.883 9.713 −11.071 1.00 54.33 C ATOM 901 O ILE A 121 12.672 10.363 −10.409 1.00 56.66 O ATOM 902 N GLY A 122 11.001 8.818 −10.592 1.00 58.02 N ATOM 903 CA GLY A 122 10.735 8.558 −9.159 1.00 53.84 C ATOM 904 C GLY A 122 10.562 7.070 −8.848 1.00 53.08 C ATOM 905 O GLY A 122 9.849 6.362 −9.538 1.00 49.84 O ATOM 906 N ILE A 123 11.194 6.610 −7.773 1.00 56.03 N ATOM 907 CA ILE A 123 11.350 5.178 −7.484 1.00 57.82 C ATOM 908 CB ILE A 123 12.641 4.623 −8.130 1.00 57.79 C ATOM 909 CG1 ILE A 123 13.822 5.552 −7.848 1.00 55.17 C ATOM 910 CD1 ILE A 123 15.124 5.005 −8.342 1.00 56.03 C ATOM 911 CG2 ILE A 123 12.463 4.418 −9.635 1.00 58.20 C ATOM 912 C ILE A 123 11.435 4.884 −5.987 1.00 60.01 C ATOM 913 O ILE A 123 11.892 5.725 −5.215 1.00 60.53 O ATOM 914 N ILE A 124 11.044 3.672 −5.591 1.00 60.36 N ATOM 915 CA ILE A 124 11.049 3.293 −4.198 1.00 61.06 C ATOM 916 CB ILE A 124 9.604 3.162 −3.717 1.00 63.31 C ATOM 917 CG1 ILE A 124 8.814 4.427 −4.091 1.00 63.35 C ATOM 918 CD1 ILE A 124 7.513 4.639 −3.345 1.00 63.23 C ATOM 919 CG2 ILE A 124 9.546 2.888 −2.211 1.00 67.90 C ATOM 920 C ILE A 124 11.766 1.968 −4.025 1.00 64.99 C ATOM 921 O ILE A 124 11.475 1.030 −4.743 1.00 67.05 O ATOM 922 N ASP A 125 12.671 1.864 −3.055 1.00 72.94 N ATOM 923 CA ASP A 125 13.356 0.582 −2.820 1.00 79.86 C ATOM 924 CB ASP A 125 14.581 0.699 −1.867 1.00 84.31 C ATOM 925 CG ASP A 125 14.290 0.272 −0.427 1.00 85.41 C ATOM 926 OD1 ASP A 125 13.733 1.099 0.330 1.00 90.46 O ATOM 927 OD2 ASP A 125 14.663 −0.869 −0.052 1.00 80.49 O ATOM 928 C ASP A 125 12.347 −0.458 −2.339 1.00 79.18 C ATOM 929 O ASP A 125 11.370 −0.100 −1.680 1.00 75.13 O ATOM 930 N PRO A 126 12.579 −1.744 −2.667 1.00 81.41 N ATOM 931 CA PRO A 126 11.581 −2.753 −2.339 1.00 82.11 C ATOM 932 CB PRO A 126 12.048 −4.005 −3.089 1.00 81.06 C ATOM 933 CG PRO A 126 13.329 −3.643 −3.756 1.00 82.34 C ATOM 934 CD PRO A 126 13.816 −2.357 −3.169 1.00 82.21 C ATOM 935 C PRO A 126 11.462 −3.059 −0.866 1.00 84.35 C ATOM 936 O PRO A 126 10.485 −3.671 −0.500 1.00 85.14 O ATOM 937 N GLU A 127 12.438 −2.679 −0.036 1.00 91.04 N ATOM 938 CA GLU A 127 12.243 −2.708 1.423 1.00 93.78 C ATOM 939 CB GLU A 127 13.559 −2.584 2.184 1.00 100.16 C ATOM 940 CG GLU A 127 14.584 −3.693 2.036 1.00 102.60 C ATOM 941 CD GLU A 127 15.722 −3.479 3.041 1.00 106.00 C ATOM 942 OE1 GLU A 127 16.405 −2.412 2.957 1.00 105.48 O ATOM 943 OE2 GLU A 127 15.905 −4.353 3.931 1.00 95.68 O ATOM 944 C GLU A 127 11.327 −1.584 1.945 1.00 89.78 C ATOM 945 O GLU A 127 10.808 −1.721 3.054 1.00 91.00 O ATOM 946 N CYS A 128 11.170 −0.498 1.164 1.00 82.65 N ATOM 947 CA CYS A 128 10.444 0.754 1.521 1.00 73.84 C ATOM 948 CB CYS A 128 8.969 0.509 1.883 1.00 68.83 C ATOM 949 SG CYS A 128 8.016 −0.403 0.648 1.00 63.43 S ATOM 950 C CYS A 128 11.159 1.576 2.599 1.00 76.06 C ATOM 951 O CYS A 128 10.534 2.166 3.486 1.00 78.10 O ATOM 952 N ARG A 129 12.480 1.604 2.511 1.00 81.28 N ATOM 953 CA ARG A 129 13.284 2.495 3.322 1.00 87.79 C ATOM 954 CB ARG A 129 14.767 2.065 3.346 1.00 97.19 C ATOM 955 CG ARG A 129 15.090 0.721 4.012 1.00 106.15 C ATOM 956 CD ARG A 129 14.243 0.445 5.260 1.00 116.20 C ATOM 957 NE ARG A 129 14.997 0.042 6.455 1.00 125.77 N ATOM 958 CZ ARG A 129 15.734 0.855 7.229 1.00 126.72 C ATOM 959 NH1 ARG A 129 15.905 2.151 6.928 1.00 123.41 N ATOM 960 NH2 ARG A 129 16.331 0.355 8.316 1.00 124.06 N ATOM 961 C ARG A 129 13.175 3.899 2.787 1.00 81.98 C ATOM 962 O ARG A 129 13.117 4.847 3.556 1.00 82.54 O ATOM 963 N MET A 130 13.137 4.053 1.473 1.00 78.74 N ATOM 964 CA MET A 130 13.189 5.393 0.917 1.00 76.38 C ATOM 965 CB MET A 130 14.646 5.815 0.777 1.00 76.55 C ATOM 966 CG MET A 130 15.296 5.327 −0.529 1.00 73.80 C ATOM 967 SD MET A 130 17.080 5.382 −0.526 1.00 63.88 S ATOM 968 CE MET A 130 17.273 4.156 0.760 1.00 70.24 C ATOM 969 C MET A 130 12.584 5.525 −0.448 1.00 71.67 C ATOM 970 O MET A 130 12.331 4.529 −1.116 1.00 72.90 O ATOM 971 N ILE A 131 12.492 6.786 −0.868 1.00 66.54 N ATOM 972 CA ILE A 131 12.080 7.184 −2.194 1.00 66.48 C ATOM 973 CB ILE A 131 10.892 8.153 −2.097 1.00 67.69 C ATOM 974 CG1 ILE A 131 9.686 7.405 −1.543 1.00 71.76 C ATOM 975 CD1 ILE A 131 8.482 8.288 −1.315 1.00 75.90 C ATOM 976 CG2 ILE A 131 10.567 8.799 −3.448 1.00 67.54 C ATOM 977 C ILE A 131 13.207 7.916 −2.890 1.00 64.06 C ATOM 978 O ILE A 131 13.727 8.873 −2.336 1.00 66.49 O ATOM 979 N GLY A 132 13.556 7.485 −4.104 1.00 61.75 N ATOM 980 CA GLY A 132 14.445 8.245 −5.002 1.00 62.08 C ATOM 981 C GLY A 132 13.744 9.151 −6.041 1.00 61.44 C ATOM 982 O GLY A 132 12.796 8.736 −6.725 1.00 55.45 O ATOM 983 N LEU A 133 14.222 10.386 −6.174 1.00 58.51 N ATOM 984 CA LEU A 133 13.730 11.280 −7.209 1.00 58.80 C ATOM 985 CB LEU A 133 12.891 12.446 −6.631 1.00 58.35 C ATOM 986 CG LEU A 133 11.829 12.077 −5.594 1.00 58.28 C ATOM 987 CD1 LEU A 133 11.202 13.278 −4.946 1.00 56.03 C ATOM 988 CD2 LEU A 133 10.718 11.287 −6.234 1.00 62.47 C ATOM 989 C LEU A 133 14.920 11.819 −7.969 1.00 56.59 C ATOM 990 O LEU A 133 15.747 12.543 −7.396 1.00 58.20 O ATOM 991 N ARG A 134 14.998 11.475 −9.253 1.00 52.18 N ATOM 992 CA ARG A 134 15.910 12.140 −10.141 1.00 52.65 C ATOM 993 CB ARG A 134 16.379 11.193 −11.231 1.00 54.72 C ATOM 994 CG ARG A 134 17.621 11.694 −11.933 1.00 56.03 C ATOM 995 CD ARG A 134 17.452 12.963 −12.753 1.00 54.82 C ATOM 996 NE ARG A 134 17.683 12.626 −14.125 1.00 58.60 N ATOM 997 CZ ARG A 134 16.819 12.009 −14.912 1.00 66.06 C ATOM 998 NH1 ARG A 134 15.609 11.689 −14.496 1.00 66.45 N ATOM 999 NH2 ARG A 134 17.174 11.720 −16.155 1.00 74.13 N ATOM 1000 C ARG A 134 15.263 13.391 −10.716 1.00 54.38 C ATOM 1001 O ARG A 134 14.655 13.376 −11.776 1.00 53.55 O ATOM 1002 N LEU A 135 15.414 14.509 −10.033 1.00 59.13 N ATOM 1003 CA LEU A 135 14.765 15.718 −10.524 1.00 60.73 C ATOM 1004 CB LEU A 135 14.327 16.586 −9.351 1.00 60.08 C ATOM 1005 CG LEU A 135 13.377 15.801 −8.446 1.00 61.47 C ATOM 1006 CD1 LEU A 135 12.927 16.657 −7.292 1.00 64.80 C ATOM 1007 CD2 LEU A 135 12.166 15.243 −9.175 1.00 61.41 C ATOM 1008 C LEU A 135 15.675 16.459 −11.470 1.00 61.53 C ATOM 1009 O LEU A 135 15.268 16.877 −12.551 1.00 56.80 O ATOM 1010 N TYR A 136 16.925 16.601 −11.054 1.00 67.47 N ATOM 1011 CA TYR A 136 17.869 17.448 −11.753 1.00 65.12 C ATOM 1012 CB TYR A 136 18.195 18.600 −10.827 1.00 65.50 C ATOM 1013 CG TYR A 136 16.992 19.344 −10.234 1.00 63.22 C ATOM 1014 CD1 TYR A 136 16.332 20.283 −10.987 1.00 62.35 C ATOM 1015 CE1 TYR A 136 15.278 21.002 −10.475 1.00 63.81 C ATOM 1016 CZ TYR A 136 14.845 20.792 −9.198 1.00 64.36 C ATOM 1017 OH TYR A 136 13.750 21.573 −8.801 1.00 72.10 O ATOM 1018 CE2 TYR A 136 15.485 19.849 −8.398 1.00 60.65 C ATOM 1019 CD2 TYR A 136 16.554 19.133 −8.917 1.00 60.27 C ATOM 1020 C TYR A 136 19.149 16.690 −12.119 1.00 65.64 C ATOM 1021 O TYR A 136 19.482 15.629 −11.519 1.00 65.64 O ATOM 1022 N ASP A 137 19.851 17.233 −13.117 1.00 66.22 N ATOM 1023 CA ASP A 137 21.187 16.749 −13.506 1.00 66.54 C ATOM 1024 CB ASP A 137 21.733 17.487 −14.732 1.00 66.52 C ATOM 1025 CG ASP A 137 20.922 17.226 −16.012 1.00 66.60 C ATOM 1026 OD1 ASP A 137 20.532 16.043 −16.240 1.00 58.70 O ATOM 1027 OD2 ASP A 137 20.692 18.220 −16.774 1.00 64.00 O ATOM 1028 C ASP A 137 22.156 16.978 −12.357 1.00 69.16 C ATOM 1029 O ASP A 137 22.185 18.051 −11.712 1.00 61.90 O ATOM 1030 N GLY A 138 22.925 15.942 −12.065 1.00 75.46 N ATOM 1031 CA GLY A 138 23.926 16.031 −11.010 1.00 79.36 C ATOM 1032 C GLY A 138 23.438 15.746 −9.606 1.00 79.51 C ATOM 1033 O GLY A 138 24.254 15.691 −8.690 1.00 78.91 O ATOM 1034 N LEU A 139 22.133 15.519 −9.435 1.00 83.64 N ATOM 1035 CA LEU A 139 21.536 15.295 −8.103 1.00 84.32 C ATOM 1036 CB LEU A 139 20.766 16.550 −7.644 1.00 84.31 C ATOM 1037 CG LEU A 139 21.641 17.769 −7.259 1.00 81.84 C ATOM 1038 CD1 LEU A 139 21.052 19.150 −7.581 1.00 79.65 C ATOM 1039 CD2 LEU A 139 21.986 17.686 −5.785 1.00 80.77 C ATOM 1040 C LEU A 139 20.640 14.035 −8.053 1.00 80.52 C ATOM 1041 O LEU A 139 20.120 13.557 −9.080 1.00 87.81 O ATOM 1042 N PHE A 140 20.529 13.501 −6.842 1.00 69.03 N ATOM 1043 CA PHE A 140 19.680 12.378 −6.526 1.00 64.45 C ATOM 1044 CB PHE A 140 20.483 11.086 −6.488 1.00 62.35 C ATOM 1045 CG PHE A 140 19.614 9.855 −6.411 1.00 61.08 C ATOM 1046 CD1 PHE A 140 19.166 9.378 −5.203 1.00 59.83 C ATOM 1047 CE1 PHE A 140 18.340 8.269 −5.155 1.00 60.68 C ATOM 1048 CZ PHE A 140 17.964 7.631 −6.309 1.00 57.18 C ATOM 1049 CE2 PHE A 140 18.397 8.099 −7.515 1.00 56.23 C ATOM 1050 CD2 PHE A 140 19.203 9.208 −7.566 1.00 58.83 C ATOM 1051 C PHE A 140 18.990 12.597 −5.162 1.00 64.32 C ATOM 1052 O PHE A 140 19.573 12.359 −4.103 1.00 65.35 O ATOM 1053 N LYS A 141 17.736 13.025 −5.190 1.00 59.44 N ATOM 1054 CA LYS A 141 17.044 13.345 −3.980 1.00 57.71 C ATOM 1055 CB LYS A 141 15.840 14.186 −4.309 1.00 60.22 C ATOM 1056 CG LYS A 141 15.273 14.898 −3.099 1.00 64.16 C ATOM 1057 CD LYS A 141 14.565 16.162 −3.544 1.00 67.94 C ATOM 1058 CE LYS A 141 15.529 17.309 −3.811 1.00 69.85 C ATOM 1059 NZ LYS A 141 14.928 18.629 −3.476 1.00 74.03 N ATOM 1060 C LYS A 141 16.607 12.089 −3.265 1.00 57.67 C ATOM 1061 O LYS A 141 16.251 11.116 −3.890 1.00 60.28 O ATOM 1062 N VAL A 142 16.623 12.103 −1.947 1.00 59.38 N ATOM 1063 CA VAL A 142 16.242 10.925 −1.185 1.00 60.23 C ATOM 1064 CB VAL A 142 17.468 10.211 −0.583 1.00 58.51 C ATOM 1065 CG1 VAL A 142 17.033 9.081 0.356 1.00 55.55 C ATOM 1066 CG2 VAL A 142 18.374 9.697 −1.708 1.00 58.28 C ATOM 1067 C VAL A 142 15.309 11.334 −0.076 1.00 62.21 C ATOM 1068 O VAL A 142 15.611 12.269 0.664 1.00 60.38 O ATOM 1069 N ILE A 143 14.213 10.589 0.056 1.00 64.23 N ATOM 1070 CA ILE A 143 13.193 10.835 1.075 1.00 67.18 C ATOM 1071 CB ILE A 143 11.814 11.113 0.416 1.00 65.57 C ATOM 1072 CG1 ILE A 143 11.948 12.126 −0.729 1.00 61.69 C ATOM 1073 CD1 ILE A 143 10.648 12.754 −1.181 1.00 60.70 C ATOM 1074 CG2 ILE A 143 10.809 11.592 1.454 1.00 68.47 C ATOM 1075 C ILE A 143 13.114 9.617 2.016 1.00 70.61 C ATOM 1076 O ILE A 143 12.469 8.625 1.702 1.00 74.97 O ATOM 1077 N PRO A 144 13.774 9.674 3.179 1.00 76.12 N ATOM 1078 CA PRO A 144 13.714 8.476 4.026 1.00 75.78 C ATOM 1079 CB PRO A 144 14.604 8.844 5.223 1.00 78.95 C ATOM 1080 CG PRO A 144 14.697 10.326 5.233 1.00 78.60 C ATOM 1081 CD PRO A 144 14.497 10.788 3.820 1.00 78.11 C ATOM 1082 C PRO A 144 12.293 8.212 4.474 1.00 70.93 C ATOM 1083 O PRO A 144 11.571 9.176 4.688 1.00 68.51 O ATOM 1084 N LEU A 145 11.895 6.947 4.600 1.00 73.31 N ATOM 1085 CA LEU A 145 10.532 6.595 5.073 1.00 83.39 C ATOM 1086 CB LEU A 145 9.904 5.523 4.192 1.00 82.53 C ATOM 1087 CG LEU A 145 9.563 6.111 2.827 1.00 86.17 C ATOM 1088 CD1 LEU A 145 9.086 5.030 1.851 1.00 87.94 C ATOM 1089 CD2 LEU A 145 8.546 7.252 2.958 1.00 82.53 C ATOM 1090 C LEU A 145 10.425 6.214 6.548 1.00 93.01 C ATOM 1091 O LEU A 145 9.653 5.339 6.937 1.00 97.16 O ATOM 1092 N ASP A 146 11.198 6.922 7.361 1.00 103.14 N ATOM 1093 CA ASP A 146 10.967 7.017 8.789 1.00 104.92 C ATOM 1094 CB ASP A 146 12.023 7.960 9.438 1.00 104.61 C ATOM 1095 CG ASP A 146 13.512 7.528 9.128 1.00 105.44 C ATOM 1096 OD1 ASP A 146 13.871 6.345 9.319 1.00 101.41 O ATOM 1097 OD2 ASP A 146 14.330 8.371 8.682 1.00 101.94 O ATOM 1098 C ASP A 146 9.515 7.544 8.922 1.00 106.46 C ATOM 1099 O ASP A 146 9.184 8.610 8.390 1.00 110.71 O ATOM 1100 N ARG A 147 8.650 6.759 9.575 1.00 106.28 N ATOM 1101 CA ARG A 147 7.218 7.102 9.808 1.00 102.90 C ATOM 1102 CB ARG A 147 6.525 5.994 10.628 1.00 103.05 C ATOM 1103 CG ARG A 147 5.006 5.927 10.486 1.00 107.31 C ATOM 1104 CD ARG A 147 4.225 6.504 11.659 1.00 116.11 C ATOM 1105 NE ARG A 147 4.407 5.769 12.927 1.00 124.20 N ATOM 1106 CZ ARG A 147 5.235 6.098 13.938 1.00 127.81 C ATOM 1107 NH1 ARG A 147 6.039 7.170 13.877 1.00 130.63 N ATOM 1108 NH2 ARG A 147 5.273 5.330 15.039 1.00 120.64 N ATOM 1109 C ARG A 147 7.000 8.463 10.495 1.00 100.71 C ATOM 1110 O ARG A 147 5.961 9.104 10.312 1.00 97.22 O ATOM 1111 N ASP A 148 7.988 8.898 11.280 1.00 102.04 N ATOM 1112 CA ASP A 148 7.983 10.228 11.881 1.00 95.48 C ATOM 1113 CB ASP A 148 9.078 10.338 12.966 1.00 89.14 C ATOM 1114 C ASP A 148 8.103 11.367 10.837 1.00 88.69 C ATOM 1115 O ASP A 148 7.857 12.524 11.218 1.00 84.24 O ATOM 1116 N ASN A 149 8.447 11.051 9.562 1.00 81.37 N ATOM 1117 CA ASN A 149 8.644 12.063 8.454 1.00 74.51 C ATOM 1118 CB ASN A 149 9.711 11.588 7.434 1.00 69.84 C ATOM 1119 CG ASN A 149 10.177 12.702 6.468 1.00 66.99 C ATOM 1120 OD1 ASN A 149 9.757 13.864 6.544 1.00 64.54 O ATOM 1121 ND2 ASN A 149 11.043 12.327 5.533 1.00 65.10 N ATOM 1122 C ASN A 149 7.374 12.526 7.705 1.00 66.76 C ATOM 1123 O ASN A 149 7.212 12.303 6.501 1.00 64.69 O ATOM 1124 N LYS A 150 6.510 13.223 8.427 1.00 62.55 N ATOM 1125 CA LYS A 150 5.243 13.660 7.874 1.00 62.63 C ATOM 1126 CB LYS A 150 4.196 13.862 8.996 1.00 58.86 C ATOM 1127 C LYS A 150 5.383 14.876 6.912 1.00 62.19 C ATOM 1128 O LYS A 150 4.436 15.147 6.169 1.00 60.62 O ATOM 1129 N GLU A 151 6.547 15.559 6.885 1.00 62.30 N ATOM 1130 CA GLU A 151 6.795 16.742 5.995 1.00 61.41 C ATOM 1131 CB GLU A 151 7.428 17.879 6.788 1.00 62.71 C ATOM 1132 CG GLU A 151 6.481 18.560 7.749 1.00 67.16 C ATOM 1133 CD GLU A 151 7.170 19.611 8.616 1.00 73.40 C ATOM 1134 OE1 GLU A 151 7.227 19.474 9.871 1.00 76.92 O ATOM 1135 OE2 GLU A 151 7.670 20.589 8.033 1.00 78.92 O ATOM 1136 C GLU A 151 7.662 16.447 4.736 1.00 63.59 C ATOM 1137 O GLU A 151 8.006 17.370 3.955 1.00 53.77 O ATOM 1138 N LEU A 152 7.960 15.156 4.527 1.00 67.75 N ATOM 1139 CA LEU A 152 8.765 14.653 3.391 1.00 69.82 C ATOM 1140 CB LEU A 152 7.965 14.553 2.062 1.00 69.18 C ATOM 1141 CG LEU A 152 6.708 13.658 2.142 1.00 72.05 C ATOM 1142 CD1 LEU A 152 5.914 13.501 0.841 1.00 73.55 C ATOM 1143 CD2 LEU A 152 7.068 12.284 2.674 1.00 72.25 C ATOM 1144 C LEU A 152 10.047 15.456 3.268 1.00 71.32 C ATOM 1145 O LEU A 152 10.511 15.822 2.136 1.00 69.99 O ATOM 1146 N LYS A 153 10.617 15.705 4.463 1.00 66.49 N ATOM 1147 CA LYS A 153 11.912 16.352 4.577 1.00 63.93 C ATOM 1148 CB LYS A 153 12.197 16.773 6.035 1.00 58.05 C ATOM 1149 C LYS A 153 12.866 15.300 3.961 1.00 66.33 C ATOM 1150 O LYS A 153 12.633 14.087 4.065 1.00 70.86 O ATOM 1151 N ALA A 154 13.885 15.764 3.255 1.00 66.25 N ATOM 1152 CA ALA A 154 14.655 14.916 2.366 1.00 67.17 C ATOM 1153 CB ALA A 154 13.885 14.841 1.080 1.00 71.22 C ATOM 1154 C ALA A 154 16.055 15.485 2.092 1.00 68.84 C ATOM 1155 O ALA A 154 16.243 16.690 2.185 1.00 75.34 O ATOM 1156 N PHE A 155 17.025 14.644 1.718 1.00 68.22 N ATOM 1157 CA PHE A 155 18.380 15.133 1.304 1.00 65.45 C ATOM 1158 CB PHE A 155 19.501 14.605 2.238 1.00 61.17 C ATOM 1159 CG PHE A 155 19.612 13.105 2.276 1.00 59.83 C ATOM 1160 CD1 PHE A 155 20.330 12.412 1.283 1.00 61.45 C ATOM 1161 CE1 PHE A 155 20.427 11.021 1.301 1.00 61.14 C ATOM 1162 CZ PHE A 155 19.811 10.308 2.325 1.00 61.01 C ATOM 1163 CE2 PHE A 155 19.109 10.990 3.333 1.00 59.05 C ATOM 1164 CD2 PHE A 155 19.009 12.376 3.302 1.00 56.86 C ATOM 1165 C PHE A 155 18.729 14.873 −0.188 1.00 65.03 C ATOM 1166 O PHE A 155 18.074 14.107 −0.897 1.00 63.22 O ATOM 1167 N ASN A 156 19.781 15.539 −0.633 1.00 63.77 N ATOM 1168 CA ASN A 156 20.359 15.301 −1.930 1.00 64.42 C ATOM 1169 CB ASN A 156 20.539 16.646 −2.610 1.00 63.60 C ATOM 1170 CG ASN A 156 19.315 17.079 −3.371 1.00 66.25 C ATOM 1171 OD1 ASN A 156 18.887 18.204 −3.236 1.00 70.96 O ATOM 1172 ND2 ASN A 156 18.785 16.211 −4.230 1.00 69.22 N ATOM 1173 C ASN A 156 21.706 14.533 −1.852 1.00 65.12 C ATOM 1174 O ASN A 156 22.315 14.442 −0.796 1.00 68.69 O ATOM 1175 N ILE A 157 22.130 13.949 −2.964 1.00 63.30 N ATOM 1176 CA ILE A 157 23.432 13.298 −3.086 1.00 67.57 C ATOM 1177 CB ILE A 157 23.335 11.740 −2.983 1.00 65.69 C ATOM 1178 CG1 ILE A 157 22.661 11.275 −1.685 1.00 64.99 C ATOM 1179 CD1 ILE A 157 22.465 9.761 −1.576 1.00 63.29 C ATOM 1180 CG2 ILE A 157 24.712 11.098 −3.048 1.00 67.60 C ATOM 1181 C ILE A 157 23.962 13.679 −4.475 1.00 71.69 C ATOM 1182 O ILE A 157 23.318 13.338 −5.461 1.00 81.83 O ATOM 1183 N ARG A 158 25.108 14.365 −4.579 1.00 71.02 N ATOM 1184 CA ARG A 158 25.693 14.636 −5.902 1.00 68.43 C ATOM 1185 CB ARG A 158 26.893 15.616 −5.831 1.00 61.31 C ATOM 1186 C ARG A 158 26.029 13.262 −6.551 1.00 70.65 C ATOM 1187 O ARG A 158 26.596 12.383 −5.889 1.00 64.71 O ATOM 1188 N LEU A 159 25.545 13.044 −7.783 1.00 77.81 N ATOM 1189 CA LEU A 159 26.068 12.000 −8.686 1.00 82.59 C ATOM 1190 CB LEU A 159 25.080 11.590 −9.769 1.00 83.21 C ATOM 1191 CG LEU A 159 23.621 11.297 −9.509 1.00 89.86 C ATOM 1192 CD1 LEU A 159 22.742 11.906 −10.617 1.00 93.61 C ATOM 1193 CD2 LEU A 159 23.436 9.788 −9.397 1.00 90.89 C ATOM 1194 C LEU A 159 27.172 12.635 −9.486 1.00 90.29 C ATOM 1195 O LEU A 159 27.084 13.811 −9.841 1.00 95.60 O ATOM 1196 N GLU A 160 28.172 11.854 −9.861 1.00 99.61 N ATOM 1197 CA GLU A 160 29.114 12.316 −10.881 1.00 105.09 C ATOM 1198 CB GLU A 160 30.323 11.353 −11.007 1.00 110.18 C ATOM 1199 CG GLU A 160 31.315 11.383 −9.830 1.00 108.14 C ATOM 1200 CD GLU A 160 31.883 12.776 −9.568 1.00 103.57 C ATOM 1201 OE1 GLU A 160 32.924 13.156 −10.176 1.00 97.79 O ATOM 1202 OE2 GLU A 160 31.260 13.494 −8.759 1.00 91.14 O ATOM 1203 C GLU A 160 28.394 12.504 −12.233 1.00 103.06 C ATOM 1204 O GLU A 160 28.495 13.571 −12.846 1.00 102.28 O ATOM 1205 N GLU A 161 27.591 11.509 −12.616 1.00 98.59 N ATOM 1206 CA GLU A 161 27.161 11.306 −13.995 1.00 92.57 C ATOM 1207 CB GLU A 161 26.743 9.856 −14.218 1.00 90.13 C ATOM 1208 CG GLU A 161 27.855 8.851 −13.934 1.00 96.42 C ATOM 1209 CD GLU A 161 28.083 8.543 −12.448 1.00 102.15 C ATOM 1210 OE1 GLU A 161 27.501 9.209 −11.562 1.00 102.32 O ATOM 1211 OE2 GLU A 161 28.866 7.624 −12.145 1.00 106.89 O ATOM 1212 C GLU A 161 26.015 12.244 −14.320 1.00 87.41 C ATOM 1213 O GLU A 161 24.926 12.105 −13.792 1.00 86.43 O ATOM 1214 N LEU A 162 26.279 13.210 −15.188 1.00 86.46 N ATOM 1215 CA LEU A 162 25.307 14.239 −15.510 1.00 84.62 C ATOM 1216 CB LEU A 162 26.011 15.497 −16.044 1.00 87.80 C ATOM 1217 CG LEU A 162 27.057 16.205 −15.168 1.00 91.35 C ATOM 1218 CD1 LEU A 162 27.283 17.628 −15.689 1.00 90.66 C ATOM 1219 CD2 LEU A 162 26.691 16.225 −13.680 1.00 91.70 C ATOM 1220 C LEU A 162 24.237 13.843 −16.511 1.00 81.47 C ATOM 1221 O LEU A 162 23.350 14.640 −16.729 1.00 86.07 O ATOM 1222 N HIS A 163 24.297 12.674 −17.146 1.00 79.73 N ATOM 1223 CA HIS A 163 23.324 12.358 −18.189 1.00 78.24 C ATOM 1224 CB HIS A 163 23.970 12.451 −19.564 1.00 85.57 C ATOM 1225 CG HIS A 163 24.428 13.826 −19.950 1.00 96.98 C ATOM 1226 ND1 HIS A 163 23.871 14.986 −19.441 1.00 105.83 N ATOM 1227 CE1 HIS A 163 24.458 16.036 −19.987 1.00 104.29 C ATOM 1228 NE2 HIS A 163 25.361 15.601 −20.848 1.00 106.11 N ATOM 1229 CD2 HIS A 163 25.355 14.225 −20.853 1.00 100.27 C ATOM 1230 C HIS A 163 22.685 10.994 −18.010 1.00 75.62 C ATOM 1231 O HIS A 163 22.723 10.174 −18.920 1.00 77.41 O ATOM 1232 N VAL A 164 22.048 10.782 −16.858 1.00 70.22 N ATOM 1233 CA VAL A 164 21.323 9.526 −16.557 1.00 68.83 C ATOM 1234 CB VAL A 164 20.826 9.482 −15.087 1.00 67.65 C ATOM 1235 CG1 VAL A 164 20.204 8.109 −14.774 1.00 66.02 C ATOM 1236 CG2 VAL A 164 21.943 9.825 −14.120 1.00 66.95 C ATOM 1237 C VAL A 164 20.061 9.273 −17.417 1.00 67.25 C ATOM 1238 O VAL A 164 19.173 10.110 −17.469 1.00 63.74 O ATOM 1239 N ILE A 165 19.933 8.077 −17.984 1.00 68.13 N ATOM 1240 CA ILE A 165 18.794 7.752 −18.843 1.00 69.27 C ATOM 1241 CB ILE A 165 19.206 6.845 −20.012 1.00 68.97 C ATOM 1242 CG1 ILE A 165 20.431 7.420 −20.717 1.00 69.87 C ATOM 1243 CD1 ILE A 165 20.289 8.873 −21.098 1.00 71.18 C ATOM 1244 CG2 ILE A 165 18.079 6.719 −21.024 1.00 69.26 C ATOM 1245 C ILE A 165 17.588 7.200 −18.071 1.00 70.25 C ATOM 1246 O ILE A 165 16.608 7.913 −17.971 1.00 79.84 O ATOM 1247 N ASP A 166 17.636 5.966 −17.555 1.00 67.06 N ATOM 1248 CA ASP A 166 16.576 5.401 −16.659 1.00 68.43 C ATOM 1249 CB ASP A 166 15.825 4.241 −17.322 1.00 70.29 C ATOM 1250 CG ASP A 166 14.467 3.959 −16.683 1.00 74.75 C ATOM 1251 OD1 ASP A 166 13.572 4.819 −16.808 1.00 84.75 O ATOM 1252 OD2 ASP A 166 14.285 2.887 −16.073 1.00 66.72 O ATOM 1253 C ASP A 166 17.248 4.955 −15.334 1.00 69.74 C ATOM 1254 O ASP A 166 18.458 5.170 −15.177 1.00 70.30 O ATOM 1255 N VAL A 167 16.483 4.410 −14.373 1.00 66.14 N ATOM 1256 CA VAL A 167 17.047 3.971 −13.079 1.00 66.10 C ATOM 1257 CB VAL A 167 17.651 5.139 −12.229 1.00 66.92 C ATOM 1258 CG1 VAL A 167 16.676 6.279 −12.066 1.00 73.11 C ATOM 1259 CG2 VAL A 167 18.083 4.690 −10.840 1.00 66.63 C ATOM 1260 C VAL A 167 16.033 3.239 −12.226 1.00 64.03 C ATOM 1261 O VAL A 167 14.878 3.618 −12.155 1.00 68.52 O ATOM 1262 N LYS A 168 16.482 2.200 −11.559 1.00 61.62 N ATOM 1263 CA LYS A 168 15.646 1.505 −10.632 1.00 63.59 C ATOM 1264 CB LYS A 168 15.253 0.178 −11.234 1.00 66.00 C ATOM 1265 CG LYS A 168 13.787 0.103 −11.598 1.00 69.47 C ATOM 1266 CD LYS A 168 13.539 0.591 −12.988 1.00 66.48 C ATOM 1267 CE LYS A 168 12.068 0.782 −13.224 1.00 67.53 C ATOM 1268 NZ LYS A 168 11.929 1.897 −14.194 1.00 73.55 N ATOM 1269 C LYS A 168 16.341 1.263 −9.325 1.00 63.94 C ATOM 1270 O LYS A 168 17.485 1.583 −9.166 1.00 69.45 O ATOM 1271 N PHE A 169 15.600 0.723 −8.383 1.00 66.36 N ATOM 1272 CA PHE A 169 16.153 0.101 −7.203 1.00 68.24 C ATOM 1273 CB PHE A 169 15.291 0.405 −5.950 1.00 70.91 C ATOM 1274 CG PHE A 169 15.649 1.683 −5.246 1.00 70.30 C ATOM 1275 CD1 PHE A 169 15.113 2.876 −5.638 1.00 73.00 C ATOM 1276 CE1 PHE A 169 15.459 4.048 −4.988 1.00 75.94 C ATOM 1277 CZ PHE A 169 16.332 4.028 −3.932 1.00 72.17 C ATOM 1278 CE2 PHE A 169 16.857 2.834 −3.523 1.00 70.91 C ATOM 1279 CD2 PHE A 169 16.527 1.678 −4.187 1.00 71.75 C ATOM 1280 C PHE A 169 16.100 −1.394 −7.506 1.00 70.64 C ATOM 1281 O PHE A 169 15.088 −1.899 −8.061 1.00 68.36 O ATOM 1282 N LEU A 170 17.163 −2.091 −7.097 1.00 71.99 N ATOM 1283 CA LEU A 170 17.312 −3.538 −7.318 1.00 72.42 C ATOM 1284 CB LEU A 170 18.784 −3.900 −7.556 1.00 72.80 C ATOM 1285 CG LEU A 170 19.464 −3.168 −8.743 1.00 74.90 C ATOM 1286 CD1 LEU A 170 20.968 −3.033 −8.556 1.00 75.96 C ATOM 1287 CD2 LEU A 170 19.161 −3.829 −10.079 1.00 75.75 C ATOM 1288 C LEU A 170 16.771 −4.318 −6.142 1.00 72.17 C ATOM 1289 O LEU A 170 16.609 −3.776 −5.047 1.00 70.71 O ATOM 1290 N TYR A 171 16.492 −5.595 −6.383 1.00 74.99 N ATOM 1291 CA TYR A 171 15.990 −6.486 −5.344 1.00 76.47 C ATOM 1292 CB TYR A 171 14.951 −7.466 −5.917 1.00 75.66 C ATOM 1293 CG TYR A 171 13.631 −6.809 −6.334 1.00 73.60 C ATOM 1294 CD1 TYR A 171 13.586 −5.898 −7.389 1.00 72.17 C ATOM 1295 CE1 TYR A 171 12.410 −5.296 −7.777 1.00 72.37 C ATOM 1296 CZ TYR A 171 11.235 −5.608 −7.121 1.00 76.46 C ATOM 1297 OH TYR A 171 10.058 −4.989 −7.530 1.00 80.71 O ATOM 1298 CE2 TYR A 171 11.245 −6.515 −6.067 1.00 73.39 C ATOM 1299 CD2 TYR A 171 12.434 −7.120 −5.690 1.00 72.56 C ATOM 1300 C TYR A 171 17.167 −7.227 −4.729 1.00 80.55 C ATOM 1301 O TYR A 171 18.270 −7.238 −5.285 1.00 82.05 O ATOM 1302 N GLY A 172 16.927 −7.809 −3.559 1.00 89.43 N ATOM 1303 CA GLY A 172 17.869 −8.736 −2.904 1.00 92.31 C ATOM 1304 C GLY A 172 19.275 −8.206 −2.701 1.00 92.96 C ATOM 1305 O GLY A 172 20.186 −8.627 −3.397 1.00 96.39 O ATOM 1306 N CYS A 173 19.443 −7.288 −1.750 1.00 95.72 N ATOM 1307 CA CYS A 173 20.749 −6.663 −1.444 1.00 94.99 C ATOM 1308 CB CYS A 173 20.870 −5.323 −2.186 1.00 92.09 C ATOM 1309 SG CYS A 173 20.688 −5.340 −3.983 1.00 88.80 S ATOM 1310 C CYS A 173 20.963 −6.429 0.085 1.00 97.24 C ATOM 1311 O CYS A 173 20.049 −5.969 0.786 1.00 89.97 O ATOM 1312 N GLN A 174 22.170 −6.723 0.595 1.00 102.37 N ATOM 1313 CA GLN A 174 22.522 −6.437 2.010 1.00 99.99 C ATOM 1314 CB GLN A 174 24.011 −6.776 2.320 1.00 92.67 C ATOM 1315 C GLN A 174 22.152 −4.968 2.353 1.00 96.62 C ATOM 1316 O GLN A 174 21.755 −4.690 3.491 1.00 93.57 O ATOM 1317 N ALA A 175 22.253 −4.067 1.354 1.00 92.10 N ATOM 1318 CA ALA A 175 21.786 −2.668 1.447 1.00 93.37 C ATOM 1319 CB ALA A 175 22.965 −1.764 1.778 1.00 89.15 C ATOM 1320 C ALA A 175 21.042 −2.127 0.169 1.00 97.74 C ATOM 1321 O ALA A 175 21.334 −2.552 −0.946 1.00 98.97 O ATOM 1322 N PRO A 176 20.073 −1.187 0.337 1.00 98.23 N ATOM 1323 CA PRO A 176 19.461 −0.360 −0.708 1.00 90.54 C ATOM 1324 CB PRO A 176 18.948 0.812 0.095 1.00 91.72 C ATOM 1325 CG PRO A 176 18.368 0.116 1.285 1.00 96.31 C ATOM 1326 CD PRO A 176 19.295 −1.035 1.584 1.00 99.65 C ATOM 1327 C PRO A 176 20.378 0.144 −1.793 1.00 85.16 C ATOM 1328 O PRO A 176 21.264 0.952 −1.534 1.00 90.91 O ATOM 1329 N THR A 177 20.101 −0.298 −3.010 1.00 80.61 N ATOM 1330 CA THR A 177 21.019 −0.187 −4.125 1.00 77.62 C ATOM 1331 CB THR A 177 21.719 −1.540 −4.316 1.00 81.21 C ATOM 1332 OG1 THR A 177 22.590 −1.772 −3.199 1.00 82.06 O ATOM 1333 CG2 THR A 177 22.526 −1.609 −5.615 1.00 80.58 C ATOM 1334 C THR A 177 20.287 0.165 −5.407 1.00 71.72 C ATOM 1335 O THR A 177 19.322 −0.498 −5.760 1.00 65.51 O ATOM 1336 N ILE A 178 20.808 1.175 −6.111 1.00 73.56 N ATOM 1337 CA ILE A 178 20.235 1.708 −7.378 1.00 74.82 C ATOM 1338 CB ILE A 178 19.972 3.244 −7.313 1.00 73.16 C ATOM 1339 CG1 ILE A 178 21.274 4.046 −7.188 1.00 71.52 C ATOM 1340 CD1 ILE A 178 21.513 5.011 −8.321 1.00 73.25 C ATOM 1341 CG2 ILE A 178 18.995 3.585 −6.173 1.00 72.08 C ATOM 1342 C ILE A 178 21.071 1.421 −8.637 1.00 70.58 C ATOM 1343 O ILE A 178 22.286 1.481 −8.593 1.00 71.95 O ATOM 1344 N CYS A 179 20.403 1.139 −9.747 1.00 68.37 N ATOM 1345 CA CYS A 179 21.058 0.674 −10.961 1.00 74.38 C ATOM 1346 CB CYS A 179 20.576 −0.734 −11.276 1.00 76.18 C ATOM 1347 SG CYS A 179 21.081 −1.310 −12.918 1.00 82.74 S ATOM 1348 C CYS A 179 20.673 1.562 −12.111 1.00 72.57 C ATOM 1349 O CYS A 179 19.490 1.797 −12.244 1.00 78.14 O ATOM 1350 N PHE A 180 21.609 2.016 −12.963 1.00 68.85 N ATOM 1351 CA PHE A 180 21.237 3.000 −14.004 1.00 68.83 C ATOM 1352 CB PHE A 180 21.071 4.354 −13.360 1.00 70.12 C ATOM 1353 CG PHE A 180 22.345 4.942 −12.822 1.00 70.80 C ATOM 1354 CD1 PHE A 180 22.819 4.568 −11.560 1.00 70.74 C ATOM 1355 CE1 PHE A 180 23.969 5.146 −11.035 1.00 72.48 C ATOM 1356 CZ PHE A 180 24.662 6.103 −11.773 1.00 72.26 C ATOM 1357 CE2 PHE A 180 24.196 6.477 −13.035 1.00 71.49 C ATOM 1358 CD2 PHE A 180 23.043 5.908 −13.552 1.00 67.58 C ATOM 1359 C PHE A 180 22.122 3.256 −15.208 1.00 69.99 C ATOM 1360 O PHE A 180 23.304 3.429 −15.073 1.00 80.68 O ATOM 1361 N VAL A 181 21.509 3.437 −16.362 1.00 67.46 N ATOM 1362 CA VAL A 181 22.221 3.791 −17.570 1.00 68.07 C ATOM 1363 CB VAL A 181 21.363 3.448 −18.779 1.00 70.23 C ATOM 1364 CG1 VAL A 181 22.041 3.908 −20.068 1.00 74.18 C ATOM 1365 CG2 VAL A 181 21.063 1.954 −18.781 1.00 71.51 C ATOM 1366 C VAL A 181 22.517 5.290 −17.634 1.00 70.58 C ATOM 1367 O VAL A 181 21.643 6.094 −17.349 1.00 71.41 O ATOM 1368 N TYR A 182 23.723 5.656 −18.071 1.00 73.36 N ATOM 1369 CA TYR A 182 24.137 7.059 −18.211 1.00 74.65 C ATOM 1370 CB TYR A 182 25.016 7.514 −17.042 1.00 83.22 C ATOM 1371 CG TYR A 182 26.291 6.739 −16.815 1.00 89.44 C ATOM 1372 CD1 TYR A 182 26.247 5.460 −16.268 1.00 95.74 C ATOM 1373 CE1 TYR A 182 27.400 4.732 −16.024 1.00 98.76 C ATOM 1374 CZ TYR A 182 28.626 5.281 −16.289 1.00 97.02 C ATOM 1375 OH TYR A 182 29.714 4.490 −16.028 1.00 95.82 O ATOM 1376 CE2 TYR A 182 28.717 6.572 −16.812 1.00 96.27 C ATOM 1377 CD2 TYR A 182 27.546 7.298 −17.073 1.00 92.57 C ATOM 1378 C TYR A 182 24.847 7.294 −19.519 1.00 71.30 C ATOM 1379 O TYR A 182 24.988 6.363 −20.307 1.00 65.25 O ATOM 1380 N GLN A 183 25.239 8.547 −19.771 1.00 69.97 N ATOM 1381 CA GLN A 183 25.950 8.860 −20.979 1.00 72.79 C ATOM 1382 CB GLN A 183 24.997 9.085 −22.135 1.00 68.44 C ATOM 1383 CG GLN A 183 25.672 8.663 −23.415 1.00 71.13 C ATOM 1384 CD GLN A 183 24.967 9.121 −24.652 1.00 74.76 C ATOM 1385 OE1 GLN A 183 24.843 10.330 −24.862 1.00 73.07 O ATOM 1386 NE2 GLN A 183 24.548 8.167 −25.524 1.00 77.20 N ATOM 1387 C GLN A 183 26.940 10.016 −20.889 1.00 83.54 C ATOM 1388 O GLN A 183 26.556 11.184 −20.784 1.00 87.62 O ATOM 1389 N ASP A 184 28.226 9.662 −20.990 1.00 92.80 N ATOM 1390 CA ASP A 184 29.351 10.631 −21.056 1.00 92.20 C ATOM 1391 CB ASP A 184 30.442 10.307 −19.986 1.00 82.18 C ATOM 1392 CG ASP A 184 30.817 8.847 −19.940 1.00 78.83 C ATOM 1393 OD1 ASP A 184 30.779 8.199 −21.002 1.00 85.55 O ATOM 1394 OD2 ASP A 184 31.154 8.332 −18.860 1.00 71.55 O ATOM 1395 C ASP A 184 29.890 10.732 −22.523 1.00 95.33 C ATOM 1396 O ASP A 184 29.440 9.968 −23.414 1.00 85.42 O ATOM 1397 N PRO A 185 30.833 11.681 −22.784 1.00 95.79 N ATOM 1398 CA PRO A 185 31.293 11.771 −24.179 1.00 94.16 C ATOM 1399 CB PRO A 185 32.075 13.104 −24.220 1.00 94.73 C ATOM 1400 CG PRO A 185 31.911 13.737 −22.854 1.00 93.00 C ATOM 1401 CD PRO A 185 31.533 12.651 −21.910 1.00 89.84 C ATOM 1402 C PRO A 185 32.172 10.579 −24.637 1.00 92.58 C ATOM 1403 O PRO A 185 32.682 10.640 −25.761 1.00 86.48 O ATOM 1404 N GLN A 186 32.372 9.553 −23.774 1.00 92.12 N ATOM 1405 CA GLN A 186 32.927 8.230 −24.168 1.00 90.88 C ATOM 1406 CB GLN A 186 33.742 7.576 −23.037 1.00 82.64 C ATOM 1407 C GLN A 186 31.815 7.293 −24.697 1.00 93.36 C ATOM 1408 O GLN A 186 31.953 6.770 −25.811 1.00 91.61 O ATOM 1409 N GLY A 187 30.713 7.111 −23.949 1.00 96.14 N ATOM 1410 CA GLY A 187 29.537 6.330 −24.457 1.00 96.40 C ATOM 1411 C GLY A 187 28.361 6.139 −23.495 1.00 92.97 C ATOM 1412 O GLY A 187 28.126 7.000 −22.657 1.00 85.56 O ATOM 1413 N ARG A 188 27.642 5.010 −23.615 1.00 91.25 N ATOM 1414 CA ARG A 188 26.528 4.648 −22.705 1.00 93.83 C ATOM 1415 CB ARG A 188 25.226 4.321 −23.472 1.00 99.71 C ATOM 1416 CG ARG A 188 24.223 5.449 −23.432 1.00 102.89 C ATOM 1417 CD ARG A 188 22.773 5.121 −23.724 1.00 99.68 C ATOM 1418 NE ARG A 188 22.259 6.326 −24.360 1.00 107.07 N ATOM 1419 CZ ARG A 188 21.142 6.434 −25.062 1.00 113.62 C ATOM 1420 NH1 ARG A 188 20.309 5.414 −25.187 1.00 114.44 N ATOM 1421 NH2 ARG A 188 20.845 7.608 −25.616 1.00 117.13 N ATOM 1422 C ARG A 188 26.830 3.437 −21.865 1.00 90.36 C ATOM 1423 O ARG A 188 27.020 2.357 −22.418 1.00 91.08 O ATOM 1424 N HIS A 189 26.821 3.595 −20.542 1.00 86.14 N ATOM 1425 CA HIS A 189 27.211 2.510 −19.628 1.00 86.74 C ATOM 1426 CB HIS A 189 28.585 2.814 −19.000 1.00 94.47 C ATOM 1427 CG HIS A 189 29.404 3.799 −19.773 1.00 92.95 C ATOM 1428 ND1 HIS A 189 29.668 3.650 −21.118 1.00 93.70 N ATOM 1429 CE1 HIS A 189 30.405 4.660 −21.533 1.00 94.37 C ATOM 1430 NE2 HIS A 189 30.634 5.456 −20.505 1.00 93.49 N ATOM 1431 CD2 HIS A 189 30.027 4.935 −19.391 1.00 89.59 C ATOM 1432 C HIS A 189 26.229 2.318 −18.498 1.00 80.46 C ATOM 1433 O HIS A 189 25.521 3.244 −18.141 1.00 78.55 O ATOM 1434 N VAL A 190 26.235 1.136 −17.886 1.00 77.54 N ATOM 1435 CA VAL A 190 25.486 0.936 −16.621 1.00 74.97 C ATOM 1436 CB VAL A 190 24.426 −0.231 −16.660 1.00 73.17 C ATOM 1437 CG1 VAL A 190 24.846 −1.384 −17.527 1.00 77.47 C ATOM 1438 CG2 VAL A 190 24.052 −0.763 −15.284 1.00 72.17 C ATOM 1439 C VAL A 190 26.465 0.949 −15.419 1.00 76.37 C ATOM 1440 O VAL A 190 27.655 0.687 −15.558 1.00 78.31 O ATOM 1441 N LYS A 191 25.913 1.294 −14.267 1.00 79.89 N ATOM 1442 CA LYS A 191 26.643 1.453 −13.036 1.00 78.24 C ATOM 1443 CB LYS A 191 27.126 2.883 −12.975 1.00 78.08 C ATOM 1444 CG LYS A 191 28.017 3.218 −11.806 1.00 87.08 C ATOM 1445 CD LYS A 191 28.454 4.663 −11.929 1.00 93.49 C ATOM 1446 CE LYS A 191 29.686 4.978 −11.112 1.00 95.62 C ATOM 1447 NZ LYS A 191 29.943 6.440 −11.136 1.00 97.54 N ATOM 1448 C LYS A 191 25.661 1.248 −11.923 1.00 79.81 C ATOM 1449 O LYS A 191 24.483 1.172 −12.176 1.00 85.54 O ATOM 1450 N THR A 192 26.132 1.135 −10.691 1.00 74.10 N ATOM 1451 CA THR A 192 25.230 0.993 −9.562 1.00 71.39 C ATOM 1452 CB THR A 192 24.875 −0.460 −9.295 1.00 71.64 C ATOM 1453 OG1 THR A 192 25.943 −1.086 −8.594 1.00 72.61 O ATOM 1454 CG2 THR A 192 24.666 −1.160 −10.577 1.00 68.02 C ATOM 1455 C THR A 192 25.858 1.597 −8.332 1.00 70.94 C ATOM 1456 O THR A 192 27.055 1.722 −8.275 1.00 77.22 O ATOM 1457 N TYR A 193 25.053 1.966 −7.351 1.00 70.41 N ATOM 1458 CA TYR A 193 25.558 2.532 −6.109 1.00 74.98 C ATOM 1459 CB TYR A 193 25.427 4.037 −6.036 1.00 75.51 C ATOM 1460 CG TYR A 193 26.239 4.830 −6.996 1.00 81.31 C ATOM 1461 CD1 TYR A 193 27.351 4.313 −7.589 1.00 86.21 C ATOM 1462 CE1 TYR A 193 28.096 5.063 −8.470 1.00 91.79 C ATOM 1463 CZ TYR A 193 27.734 6.354 −8.741 1.00 93.07 C ATOM 1464 OH TYR A 193 28.453 7.129 −9.615 1.00 89.51 O ATOM 1465 CE2 TYR A 193 26.635 6.887 −8.148 1.00 96.48 C ATOM 1466 CD2 TYR A 193 25.902 6.127 −7.274 1.00 91.27 C ATOM 1467 C TYR A 193 24.751 1.984 −4.970 1.00 74.93 C ATOM 1468 O TYR A 193 23.747 1.335 −5.169 1.00 80.70 O ATOM 1469 N GLU A 194 25.202 2.248 −3.764 1.00 76.32 N ATOM 1470 CA GLU A 194 24.489 1.818 −2.590 1.00 79.68 C ATOM 1471 CB GLU A 194 25.378 1.021 −1.668 1.00 87.98 C ATOM 1472 CG GLU A 194 25.550 −0.422 −2.073 1.00 91.79 C ATOM 1473 CD GLU A 194 25.926 −1.299 −0.907 1.00 94.25 C ATOM 1474 OE1 GLU A 194 25.955 −0.806 0.232 1.00 87.06 O ATOM 1475 OE2 GLU A 194 26.189 −2.488 −1.128 1.00 94.94 O ATOM 1476 C GLU A 194 24.059 3.093 −1.922 1.00 75.58 C ATOM 1477 O GLU A 194 24.657 4.134 −2.151 1.00 63.27 O ATOM 1478 N VAL A 195 23.013 3.025 −1.112 1.00 75.88 N ATOM 1479 CA VAL A 195 22.479 4.241 −0.457 1.00 76.97 C ATOM 1480 CB VAL A 195 21.089 4.626 −1.027 1.00 76.13 C ATOM 1481 CG1 VAL A 195 20.527 5.840 −0.305 1.00 81.35 C ATOM 1482 CG2 VAL A 195 21.189 4.961 −2.506 1.00 73.76 C ATOM 1483 C VAL A 195 22.435 4.151 1.085 1.00 75.06 C ATOM 1484 O VAL A 195 21.647 3.384 1.674 1.00 76.98 O ATOM 1485 N SER A 196 23.281 4.952 1.729 1.00 72.91 N ATOM 1486 CA SER A 196 23.273 5.040 3.167 1.00 79.27 C ATOM 1487 CB SER A 196 24.678 4.952 3.744 1.00 80.16 C ATOM 1488 OG SER A 196 24.592 4.956 5.165 1.00 80.00 O ATOM 1489 C SER A 196 22.630 6.358 3.574 1.00 84.94 C ATOM 1490 O SER A 196 23.193 7.452 3.355 1.00 78.44 O ATOM 1491 N LEU A 197 21.442 6.230 4.167 1.00 89.41 N ATOM 1492 CA LEU A 197 20.744 7.357 4.815 1.00 89.91 C ATOM 1493 CB LEU A 197 19.364 6.969 5.421 1.00 88.66 C ATOM 1494 CG LEU A 197 18.335 6.136 4.638 1.00 88.96 C ATOM 1495 CD1 LEU A 197 18.319 6.589 3.181 1.00 94.78 C ATOM 1496 CD2 LEU A 197 18.547 4.616 4.738 1.00 90.77 C ATOM 1497 C LEU A 197 21.628 7.768 5.938 1.00 87.49 C ATOM 1498 O LEU A 197 21.853 8.941 6.162 1.00 87.07 O ATOM 1499 N ARG A 198 22.121 6.740 6.616 1.00 90.26 N ATOM 1500 CA ARG A 198 22.947 6.835 7.786 1.00 92.81 C ATOM 1501 CB ARG A 198 23.365 5.401 8.132 1.00 102.74 C ATOM 1502 CG ARG A 198 23.759 5.079 9.564 1.00 110.90 C ATOM 1503 CD ARG A 198 24.113 3.585 9.626 1.00 113.87 C ATOM 1504 NE ARG A 198 25.444 3.286 10.173 1.00 120.95 N ATOM 1505 CZ ARG A 198 26.629 3.723 9.706 1.00 124.17 C ATOM 1506 NH1 ARG A 198 26.734 4.562 8.667 1.00 123.64 N ATOM 1507 NH2 ARG A 198 27.756 3.330 10.313 1.00 123.18 N ATOM 1508 C ARG A 198 24.131 7.794 7.553 1.00 86.29 C ATOM 1509 O ARG A 198 24.501 8.515 8.476 1.00 84.10 O ATOM 1510 N GLU A 199 24.676 7.825 6.324 1.00 82.72 N ATOM 1511 CA GLU A 199 25.754 8.774 5.897 1.00 84.03 C ATOM 1512 CB GLU A 199 26.924 8.038 5.215 1.00 91.08 C ATOM 1513 CG GLU A 199 27.516 6.807 5.867 1.00 94.42 C ATOM 1514 CD GLU A 199 28.588 6.202 4.971 1.00 95.97 C ATOM 1515 OE1 GLU A 199 28.256 5.382 4.071 1.00 90.86 O ATOM 1516 OE2 GLU A 199 29.759 6.600 5.150 1.00 98.36 O ATOM 1517 C GLU A 199 25.360 9.831 4.854 1.00 79.60 C ATOM 1518 O GLU A 199 26.219 10.641 4.449 1.00 70.72 O ATOM 1519 N LYS A 200 24.119 9.763 4.351 1.00 79.07 N ATOM 1520 CA LYS A 200 23.570 10.708 3.345 1.00 73.57 C ATOM 1521 CB LYS A 200 23.322 12.110 3.911 1.00 72.12 C ATOM 1522 CG LYS A 200 22.265 12.190 5.010 1.00 73.63 C ATOM 1523 CD LYS A 200 21.828 13.643 5.187 1.00 76.71 C ATOM 1524 CE LYS A 200 20.813 13.819 6.289 1.00 76.60 C ATOM 1525 NZ LYS A 200 21.480 13.607 7.601 1.00 82.13 N ATOM 1526 C LYS A 200 24.509 10.775 2.186 1.00 69.92 C ATOM 1527 O LYS A 200 24.986 11.842 1.800 1.00 65.43 O ATOM 1528 N GLU A 201 24.890 9.603 1.734 1.00 71.91 N ATOM 1529 CA GLU A 201 25.845 9.533 0.676 1.00 78.64 C ATOM 1530 CB GLU A 201 27.228 9.816 1.228 1.00 91.86 C ATOM 1531 CG GLU A 201 28.311 9.807 0.179 1.00 100.96 C ATOM 1532 CD GLU A 201 28.388 11.105 −0.590 1.00 108.09 C ATOM 1533 OE1 GLU A 201 28.560 12.161 0.049 1.00 112.25 O ATOM 1534 OE2 GLU A 201 28.295 11.067 −1.835 1.00 106.19 O ATOM 1535 C GLU A 201 25.834 8.203 −0.004 1.00 75.81 C ATOM 1536 O GLU A 201 25.286 7.239 0.492 1.00 71.35 O ATOM 1537 N PHE A 202 26.457 8.187 −1.164 1.00 78.06 N ATOM 1538 CA PHE A 202 26.590 7.016 −1.991 1.00 83.17 C ATOM 1539 CB PHE A 202 26.837 7.463 −3.412 1.00 86.53 C ATOM 1540 CG PHE A 202 25.604 7.724 −4.184 1.00 82.12 C ATOM 1541 CD1 PHE A 202 24.540 6.883 −4.082 1.00 79.38 C ATOM 1542 CE1 PHE A 202 23.403 7.116 −4.797 1.00 80.62 C ATOM 1543 CZ PHE A 202 23.338 8.191 −5.638 1.00 85.47 C ATOM 1544 CE2 PHE A 202 24.406 9.033 −5.757 1.00 84.81 C ATOM 1545 CD2 PHE A 202 25.533 8.792 −5.031 1.00 83.14 C ATOM 1546 C PHE A 202 27.777 6.163 −1.640 1.00 84.12 C ATOM 1547 O PHE A 202 28.829 6.661 −1.289 1.00 81.93 O ATOM 1548 N ASN A 203 27.615 4.864 −1.768 1.00 87.89 N ATOM 1549 CA ASN A 203 28.708 3.957 −1.543 1.00 89.06 C ATOM 1550 CB ASN A 203 28.402 2.990 −0.410 1.00 82.66 C ATOM 1551 CG ASN A 203 28.561 3.616 0.940 1.00 75.06 C ATOM 1552 OD1 ASN A 203 29.029 4.734 1.052 1.00 71.41 O ATOM 1553 ND2 ASN A 203 28.171 2.897 1.974 1.00 69.29 N ATOM 1554 C ASN A 203 28.807 3.200 −2.841 1.00 94.32 C ATOM 1555 O ASN A 203 27.804 2.718 −3.339 1.00 95.74 O ATOM 1556 N LYS A 204 29.990 3.090 −3.419 1.00 95.80 N ATOM 1557 CA LYS A 204 30.054 2.337 −4.655 1.00 93.65 C ATOM 1558 CB LYS A 204 31.477 2.367 −5.208 1.00 101.22 C ATOM 1559 CG LYS A 204 31.601 1.986 −6.684 1.00 113.30 C ATOM 1560 CD LYS A 204 32.587 0.829 −6.891 1.00 117.80 C ATOM 1561 CE LYS A 204 32.109 −0.493 −6.276 1.00 117.81 C ATOM 1562 NZ LYS A 204 33.214 −1.480 −6.087 1.00 119.23 N ATOM 1563 C LYS A 204 29.526 0.904 −4.383 1.00 86.39 C ATOM 1564 O LYS A 204 29.488 0.418 −3.235 1.00 72.00 O ATOM 1565 N GLY A 205 29.069 0.251 −5.442 1.00 86.04 N ATOM 1566 CA GLY A 205 28.228 −0.903 −5.278 1.00 87.91 C ATOM 1567 C GLY A 205 28.389 −2.010 −6.285 1.00 88.77 C ATOM 1568 O GLY A 205 29.167 −1.886 −7.240 1.00 80.97 O ATOM 1569 N PRO A 206 27.605 −3.093 −6.083 1.00 95.88 N ATOM 1570 CA PRO A 206 27.808 −4.419 −6.635 1.00 97.25 C ATOM 1571 CB PRO A 206 26.400 −5.031 −6.587 1.00 100.43 C ATOM 1572 CG PRO A 206 25.853 −4.509 −5.307 1.00 99.84 C ATOM 1573 CD PRO A 206 26.462 −3.122 −5.139 1.00 99.58 C ATOM 1574 C PRO A 206 28.415 −4.566 −8.013 1.00 92.16 C ATOM 1575 O PRO A 206 29.143 −5.528 −8.196 1.00 95.33 O ATOM 1576 N TRP A 207 28.148 −3.684 −8.976 1.00 88.56 N ATOM 1577 CA TRP A 207 28.685 −3.947 −10.325 1.00 93.77 C ATOM 1578 CB TRP A 207 28.009 −5.207 −10.943 1.00 95.32 C ATOM 1579 CG TRP A 207 26.496 −5.334 −10.879 1.00 93.50 C ATOM 1580 CD1 TRP A 207 25.731 −5.986 −9.919 1.00 93.22 C ATOM 1581 NE1 TRP A 207 24.405 −5.940 −10.261 1.00 87.26 N ATOM 1582 CE2 TRP A 207 24.294 −5.281 −11.461 1.00 92.67 C ATOM 1583 CD2 TRP A 207 25.593 −4.900 −11.874 1.00 89.25 C ATOM 1584 CE3 TRP A 207 25.750 −4.197 −13.078 1.00 89.46 C ATOM 1585 CZ3 TRP A 207 24.628 −3.893 −13.831 1.00 90.76 C ATOM 1586 CH2 TRP A 207 23.345 −4.277 −13.397 1.00 99.05 C ATOM 1587 CZ2 TRP A 207 23.157 −4.971 −12.216 1.00 99.70 C ATOM 1588 C TRP A 207 28.752 −2.751 −11.293 1.00 92.11 C ATOM 1589 O TRP A 207 28.644 −1.604 −10.847 1.00 90.25 O ATOM 1590 N LYS A 208 29.037 −3.035 −12.578 1.00 85.58 N ATOM 1591 CA LYS A 208 29.162 −2.025 −13.633 1.00 80.94 C ATOM 1592 CB LYS A 208 30.376 −1.087 −13.375 1.00 85.85 C ATOM 1593 CG LYS A 208 31.637 −1.822 −12.925 1.00 95.76 C ATOM 1594 CD LYS A 208 32.948 −1.191 −13.383 1.00 98.07 C ATOM 1595 CE LYS A 208 34.101 −2.151 −13.086 1.00 102.45 C ATOM 1596 NZ LYS A 208 35.403 −1.711 −13.660 1.00 105.02 N ATOM 1597 C LYS A 208 29.279 −2.679 −15.032 1.00 77.39 C ATOM 1598 O LYS A 208 29.247 −3.929 −15.183 1.00 73.41 O ATOM 1599 N GLN A 209 29.377 −1.791 −16.032 1.00 72.33 N ATOM 1600 CA GLN A 209 29.536 −2.110 −17.429 1.00 66.43 C ATOM 1601 CB GLN A 209 28.311 −2.906 −17.867 1.00 68.69 C ATOM 1602 CG GLN A 209 28.084 −2.971 −19.356 1.00 78.41 C ATOM 1603 CD GLN A 209 29.377 −3.157 −20.123 1.00 85.27 C ATOM 1604 OE1 GLN A 209 29.719 −2.355 −21.023 1.00 86.31 O ATOM 1605 NE2 GLN A 209 30.145 −4.182 −19.724 1.00 85.39 N ATOM 1606 C GLN A 209 29.719 −0.797 −18.256 1.00 60.22 C ATOM 1607 O GLN A 209 30.733 −0.566 −18.951 1.00 47.90 O ATOM 1608 N ASN A 211 30.586 0.236 −21.662 1.00 71.25 N ATOM 1609 CA ASN A 211 29.990 0.481 −22.997 1.00 79.14 C ATOM 1610 CB ASN A 211 31.081 0.680 −24.109 1.00 67.09 C ATOM 1611 C ASN A 211 28.928 −0.618 −23.335 1.00 84.06 C ATOM 1612 O ASN A 211 29.278 −1.643 −23.926 1.00 93.04 O ATOM 1613 N VAL A 212 27.668 −0.420 −22.868 1.00 87.14 N ATOM 1614 CA VAL A 212 26.422 −1.186 −23.310 1.00 83.01 C ATOM 1615 CB VAL A 212 25.180 −1.293 −22.322 1.00 83.12 C ATOM 1616 CG1 VAL A 212 24.804 −2.746 −22.012 1.00 81.01 C ATOM 1617 CG2 VAL A 212 25.296 −0.414 −21.082 1.00 86.65 C ATOM 1618 C VAL A 212 25.867 −0.435 −24.492 1.00 79.51 C ATOM 1619 O VAL A 212 26.356 0.676 −24.779 1.00 73.35 O ATOM 1620 N GLU A 213 24.829 −1.021 −25.118 1.00 74.80 N ATOM 1621 CA GLU A 213 24.316 −0.582 −26.421 1.00 76.44 C ATOM 1622 CB GLU A 213 22.958 −1.224 −26.723 1.00 79.83 C ATOM 1623 CG GLU A 213 22.675 −1.322 −28.222 1.00 84.47 C ATOM 1624 CD GLU A 213 21.258 −0.924 −28.599 1.00 88.82 C ATOM 1625 OE1 GLU A 213 20.308 −1.711 −28.317 1.00 87.57 O ATOM 1626 OE2 GLU A 213 21.112 0.178 −29.196 1.00 89.82 O ATOM 1627 C GLU A 213 24.213 0.930 −26.635 1.00 76.05 C ATOM 1628 O GLU A 213 23.803 1.669 −25.745 1.00 70.95 O ATOM 1629 N ALA A 214 24.590 1.374 −27.835 1.00 83.46 N ATOM 1630 CA ALA A 214 24.505 2.796 −28.240 1.00 89.09 C ATOM 1631 CB ALA A 214 24.562 2.908 −29.769 1.00 91.56 C ATOM 1632 C ALA A 214 23.252 3.512 −27.720 1.00 87.51 C ATOM 1633 O ALA A 214 23.348 4.604 −27.133 1.00 93.83 O ATOM 1634 N GLU A 215 22.101 2.858 −27.932 1.00 81.32 N ATOM 1635 CA GLU A 215 20.774 3.419 −27.737 1.00 76.19 C ATOM 1636 CB GLU A 215 20.079 3.515 −29.139 1.00 83.31 C ATOM 1637 CG GLU A 215 18.941 4.558 −29.358 1.00 91.64 C ATOM 1638 CD GLU A 215 19.326 5.944 −29.934 1.00 100.43 C ATOM 1639 OE1 GLU A 215 18.439 6.864 −29.989 1.00 107.70 O ATOM 1640 OE2 GLU A 215 20.494 6.138 −30.339 1.00 99.30 O ATOM 1641 C GLU A 215 20.003 2.579 −26.671 1.00 69.44 C ATOM 1642 O GLU A 215 18.815 2.352 −26.773 1.00 70.21 O ATOM 1643 N ALA A 216 20.684 2.137 −25.618 1.00 71.41 N ATOM 1644 CA ALA A 216 19.996 1.582 −24.415 1.00 76.29 C ATOM 1645 CB ALA A 216 20.992 0.846 −23.489 1.00 71.92 C ATOM 1646 C ALA A 216 19.221 2.702 −23.623 1.00 79.85 C ATOM 1647 O ALA A 216 19.789 3.783 −23.334 1.00 79.22 O ATOM 1648 N SER A 217 17.952 2.427 −23.275 1.00 77.23 N ATOM 1649 CA SER A 217 17.064 3.408 −22.622 1.00 72.22 C ATOM 1650 CB SER A 217 16.074 3.908 −23.648 1.00 73.40 C ATOM 1651 OG SER A 217 15.155 2.875 −23.901 1.00 78.99 O ATOM 1652 C SER A 217 16.285 2.911 −21.380 1.00 67.82 C ATOM 1653 O SER A 217 16.184 3.617 −20.419 1.00 69.16 O ATOM 1654 N MET A 218 15.714 1.724 −21.393 1.00 66.69 N ATOM 1655 CA MET A 218 14.905 1.239 −20.263 1.00 68.22 C ATOM 1656 CB MET A 218 13.745 0.458 −20.853 1.00 70.91 C ATOM 1657 CG MET A 218 12.685 −0.026 −19.882 1.00 73.50 C ATOM 1658 SD MET A 218 11.235 −0.660 −20.760 1.00 78.06 S ATOM 1659 CE MET A 218 10.913 0.605 −22.008 1.00 74.64 C ATOM 1660 C MET A 218 15.695 0.356 −19.291 1.00 66.48 C ATOM 1661 O MET A 218 16.694 −0.217 −19.647 1.00 73.89 O ATOM 1662 N VAL A 219 15.236 0.228 −18.062 1.00 64.27 N ATOM 1663 CA VAL A 219 15.936 −0.545 −17.031 1.00 62.09 C ATOM 1664 CB VAL A 219 16.611 0.429 −16.063 1.00 64.85 C ATOM 1665 CG1 VAL A 219 16.949 −0.235 −14.735 1.00 67.52 C ATOM 1666 CG2 VAL A 219 17.839 1.030 −16.715 1.00 65.31 C ATOM 1667 C VAL A 219 14.921 −1.335 −16.249 1.00 57.92 C ATOM 1668 O VAL A 219 13.909 −0.803 −15.935 1.00 63.01 O ATOM 1669 N ILE A 220 15.168 −2.577 −15.887 1.00 55.30 N ATOM 1670 CA ILE A 220 14.129 −3.337 −15.184 1.00 56.33 C ATOM 1671 CB ILE A 220 13.408 −4.357 −16.105 1.00 53.98 C ATOM 1672 CG1 ILE A 220 12.784 −3.633 −17.298 1.00 55.61 C ATOM 1673 CD1 ILE A 220 12.094 −4.534 −18.306 1.00 56.98 C ATOM 1674 CG2 ILE A 220 12.324 −5.152 −15.346 1.00 52.13 C ATOM 1675 C ILE A 220 14.702 −4.050 −13.981 1.00 58.62 C ATOM 1676 O ILE A 220 15.521 −4.907 −14.136 1.00 59.02 O ATOM 1677 N ALA A 221 14.245 −3.721 −12.778 1.00 63.31 N ATOM 1678 CA ALA A 221 14.754 −4.392 −11.589 1.00 63.96 C ATOM 1679 CB ALA A 221 14.393 −3.624 −10.333 1.00 64.31 C ATOM 1680 C ALA A 221 14.142 −5.767 −11.579 1.00 66.71 C ATOM 1681 O ALA A 221 12.915 −5.903 −11.641 1.00 65.95 O ATOM 1682 N VAL A 222 14.970 −6.790 −11.512 1.00 72.18 N ATOM 1683 CA VAL A 222 14.439 −8.127 −11.477 1.00 71.65 C ATOM 1684 CB VAL A 222 15.384 −9.151 −12.092 1.00 70.53 C ATOM 1685 CG1 VAL A 222 14.846 −10.546 −11.874 1.00 73.77 C ATOM 1686 CG2 VAL A 222 15.496 −8.902 −13.573 1.00 68.90 C ATOM 1687 C VAL A 222 14.113 −8.478 −10.058 1.00 68.68 C ATOM 1688 O VAL A 222 14.771 −8.030 −9.147 1.00 68.14 O ATOM 1689 N PRO A 223 13.045 −9.336 −9.903 1.00 70.27 N ATOM 1690 CA PRO A 223 12.724 −9.668 −8.522 1.00 77.84 C ATOM 1691 CB PRO A 223 11.357 −10.327 −8.605 1.00 78.97 C ATOM 1692 CG PRO A 223 10.797 −9.889 −9.882 1.00 79.60 C ATOM 1693 CD PRO A 223 11.978 −10.006 −10.756 1.00 74.48 C ATOM 1694 C PRO A 223 13.726 −10.609 −7.935 1.00 82.26 C ATOM 1695 O PRO A 223 14.647 −11.039 −8.601 1.00 68.31 O ATOM 1696 N GLU A 224 13.527 −10.890 −6.660 1.00 96.03 N ATOM 1697 CA GLU A 224 14.423 −11.683 −5.837 1.00 105.76 C ATOM 1698 CB GLU A 224 14.018 −11.616 −4.375 1.00 112.89 C ATOM 1699 CG GLU A 224 15.128 −12.040 −3.443 1.00 111.01 C ATOM 1700 CD GLU A 224 15.031 −11.343 −2.116 1.00 109.99 C ATOM 1701 OE1 GLU A 224 15.375 −11.954 −1.090 1.00 114.23 O ATOM 1702 OE2 GLU A 224 14.602 −10.177 −2.103 1.00 106.82 O ATOM 1703 C GLU A 224 14.681 −13.112 −6.211 1.00 99.16 C ATOM 1704 O GLU A 224 15.677 −13.671 −5.752 1.00 105.82 O ATOM 1705 N PRO A 225 13.770 −13.729 −7.055 1.00 99.08 N ATOM 1706 CA PRO A 225 14.118 −15.123 −7.373 1.00 99.88 C ATOM 1707 CB PRO A 225 13.082 −15.516 −8.406 1.00 100.30 C ATOM 1708 CG PRO A 225 11.878 −14.792 −7.973 1.00 104.55 C ATOM 1709 CD PRO A 225 12.420 −13.434 −7.701 1.00 99.73 C ATOM 1710 C PRO A 225 15.501 −15.158 −8.000 1.00 95.68 C ATOM 1711 O PRO A 225 16.292 −15.964 −7.557 1.00 87.73 O ATOM 1712 N PHE A 226 15.818 −14.284 −8.945 1.00 100.62 N ATOM 1713 CA PHE A 226 17.171 −14.269 −9.469 1.00 100.68 C ATOM 1714 CB PHE A 226 17.261 −14.286 −10.993 1.00 112.47 C ATOM 1715 CG PHE A 226 16.040 −14.778 −11.709 1.00 125.77 C ATOM 1716 CD2 PHE A 226 16.161 −15.736 −12.696 1.00 126.49 C ATOM 1717 CE2 PHE A 226 15.062 −16.176 −13.398 1.00 131.24 C ATOM 1718 CZ PHE A 226 13.823 −15.642 −13.136 1.00 129.03 C ATOM 1719 CE1 PHE A 226 13.690 −14.666 −12.172 1.00 128.50 C ATOM 1720 CD1 PHE A 226 14.798 −14.226 −11.475 1.00 130.76 C ATOM 1721 C PHE A 226 17.810 −12.971 −9.040 1.00 92.08 C ATOM 1722 O PHE A 226 18.866 −12.949 −8.433 1.00 86.64 O ATOM 1723 N GLY A 227 17.132 −11.882 −9.360 1.00 86.12 N ATOM 1724 CA GLY A 227 17.614 −10.555 −9.063 1.00 82.57 C ATOM 1725 C GLY A 227 18.422 −10.071 −10.238 1.00 79.48 C ATOM 1726 O GLY A 227 18.702 −10.844 −11.131 1.00 81.33 O ATOM 1727 N GLY A 228 18.806 −8.801 −10.234 1.00 74.75 N ATOM 1728 CA GLY A 228 19.579 −8.224 −11.318 1.00 72.35 C ATOM 1729 C GLY A 228 18.786 −7.272 −12.182 1.00 70.89 C ATOM 1730 O GLY A 228 17.653 −6.970 −11.870 1.00 73.71 O ATOM 1731 N ALA A 229 19.386 −6.801 −13.265 1.00 65.70 N ATOM 1732 CA ALA A 229 18.725 −5.852 −14.185 1.00 64.72 C ATOM 1733 CB ALA A 229 19.328 −4.450 −14.002 1.00 65.44 C ATOM 1734 C ALA A 229 18.672 −6.224 −15.702 1.00 60.94 C ATOM 1735 O ALA A 229 19.668 −6.540 −16.303 1.00 61.38 O ATOM 1736 N ILE A 230 17.491 −6.146 −16.303 1.00 62.43 N ATOM 1737 CA ILE A 230 17.300 −6.131 −17.777 1.00 65.70 C ATOM 1738 CB ILE A 230 15.915 −6.682 −18.097 1.00 66.38 C ATOM 1739 CG1 ILE A 230 15.940 −8.191 −17.926 1.00 70.77 C ATOM 1740 CD1 ILE A 230 14.617 −8.700 −17.433 1.00 73.75 C ATOM 1741 CG2 ILE A 230 15.438 −6.307 −19.477 1.00 65.32 C ATOM 1742 C ILE A 230 17.426 −4.718 −18.366 1.00 66.46 C ATOM 1743 O ILE A 230 17.068 −3.732 −17.731 1.00 74.33 O ATOM 1744 N ILE A 231 17.930 −4.601 −19.578 1.00 62.29 N ATOM 1745 CA ILE A 231 18.216 −3.287 −20.111 1.00 62.09 C ATOM 1746 CB ILE A 231 19.719 −2.927 −20.006 1.00 66.57 C ATOM 1747 CG1 ILE A 231 20.311 −3.151 −18.596 1.00 73.10 C ATOM 1748 CD1 ILE A 231 19.988 −2.112 −17.548 1.00 77.34 C ATOM 1749 CG2 ILE A 231 19.977 −1.493 −20.428 1.00 67.63 C ATOM 1750 C ILE A 231 17.824 −3.397 −21.559 1.00 61.02 C ATOM 1751 O ILE A 231 18.404 −4.179 −22.281 1.00 63.54 O ATOM 1752 N ILE A 232 16.852 −2.606 −21.986 1.00 58.99 N ATOM 1753 CA ILE A 232 16.326 −2.684 −23.322 1.00 58.91 C ATOM 1754 CB ILE A 232 14.796 −2.618 −23.310 1.00 62.72 C ATOM 1755 CG1 ILE A 232 14.188 −3.442 −22.156 1.00 67.74 C ATOM 1756 CD1 ILE A 232 14.396 −4.928 −22.243 1.00 67.11 C ATOM 1757 CG2 ILE A 232 14.219 −3.095 −24.636 1.00 64.35 C ATOM 1758 C ILE A 232 16.843 −1.500 −24.121 1.00 61.53 C ATOM 1759 O ILE A 232 17.078 −0.432 −23.563 1.00 60.82 O ATOM 1760 N GLY A 233 17.017 −1.696 −25.429 1.00 64.67 N ATOM 1761 CA GLY A 233 17.363 −0.624 −26.374 1.00 66.21 C ATOM 1762 C GLY A 233 16.641 −0.900 −27.683 1.00 73.51 C ATOM 1763 O GLY A 233 15.554 −1.546 −27.670 1.00 71.28 O ATOM 1764 N GLN A 234 17.232 −0.429 −28.801 1.00 76.29 N ATOM 1765 CA GLN A 234 16.629 −0.555 −30.153 1.00 80.98 C ATOM 1766 CB GLN A 234 17.380 0.282 −31.215 1.00 89.07 C ATOM 1767 CG GLN A 234 17.514 1.800 −30.991 1.00 97.52 C ATOM 1768 CD GLN A 234 16.250 2.641 −31.240 1.00 101.47 C ATOM 1769 OE1 GLN A 234 16.110 3.758 −30.695 1.00 96.74 O ATOM 1770 NE2 GLN A 234 15.325 2.113 −32.049 1.00 102.00 N ATOM 1771 C GLN A 234 16.705 −1.992 −30.611 1.00 82.03 C ATOM 1772 O GLN A 234 15.714 −2.579 −31.108 1.00 76.05 O ATOM 1773 N GLU A 235 17.918 −2.525 −30.437 1.00 85.63 N ATOM 1774 CA GLU A 235 18.353 −3.771 −31.023 1.00 93.07 C ATOM 1775 CB GLU A 235 19.601 −3.465 −31.881 1.00 101.00 C ATOM 1776 CG GLU A 235 20.087 −4.586 −32.815 1.00 117.77 C ATOM 1777 CD GLU A 235 19.025 −5.212 −33.752 1.00 123.52 C ATOM 1778 OE1 GLU A 235 19.304 −6.322 −34.284 1.00 126.79 O ATOM 1779 OE2 GLU A 235 17.929 −4.630 −33.975 1.00 122.02 O ATOM 1780 C GLU A 235 18.607 −4.912 −30.007 1.00 87.94 C ATOM 1781 O GLU A 235 18.502 −6.088 −30.363 1.00 82.84 O ATOM 1782 N SER A 236 18.888 −4.584 −28.747 1.00 85.46 N ATOM 1783 CA SER A 236 19.293 −5.596 −27.762 1.00 83.37 C ATOM 1784 CB SER A 236 20.751 −5.363 −27.336 1.00 89.55 C ATOM 1785 OG SER A 236 20.997 −4.011 −26.952 1.00 89.41 O ATOM 1786 C SER A 236 18.438 −5.631 −26.517 1.00 76.81 C ATOM 1787 O SER A 236 17.660 −4.744 −26.243 1.00 70.89 O ATOM 1788 N ILE A 237 18.616 −6.697 −25.765 1.00 77.70 N ATOM 1789 CA ILE A 237 17.969 −6.893 −24.477 1.00 74.16 C ATOM 1790 CB ILE A 237 16.667 −7.704 −24.588 1.00 70.66 C ATOM 1791 CG1 ILE A 237 15.636 −6.961 −25.435 1.00 68.84 C ATOM 1792 CD1 ILE A 237 14.304 −7.683 −25.549 1.00 69.77 C ATOM 1793 CG2 ILE A 237 16.115 −8.037 −23.203 1.00 70.93 C ATOM 1794 C ILE A 237 18.970 −7.689 −23.674 1.00 74.96 C ATOM 1795 O ILE A 237 19.363 −8.783 −24.060 1.00 79.03 O ATOM 1796 N THR A 238 19.352 −7.145 −22.543 1.00 76.16 N ATOM 1797 CA THR A 238 20.549 −7.556 −21.865 1.00 77.91 C ATOM 1798 CB THR A 238 21.601 −6.453 −22.028 1.00 80.32 C ATOM 1799 OG1 THR A 238 21.423 −5.822 −23.303 1.00 82.50 O ATOM 1800 CG2 THR A 238 22.977 −7.032 −21.956 1.00 85.37 C ATOM 1801 C THR A 238 20.236 −7.744 −20.405 1.00 77.17 C ATOM 1802 O THR A 238 19.775 −6.820 −19.758 1.00 80.91 O ATOM 1803 N TYR A 239 20.431 −8.946 −19.889 1.00 75.06 N ATOM 1804 CA TYR A 239 20.420 −9.128 −18.449 1.00 73.15 C ATOM 1805 CB TYR A 239 20.001 −10.513 −18.112 1.00 69.22 C ATOM 1806 CG TYR A 239 20.052 −10.802 −16.668 1.00 71.97 C ATOM 1807 CD1 TYR A 239 21.214 −11.216 −16.079 1.00 75.54 C ATOM 1808 CE1 TYR A 239 21.264 −11.516 −14.741 1.00 78.22 C ATOM 1809 CZ TYR A 239 20.141 −11.408 −13.966 1.00 77.99 C ATOM 1810 OH TYR A 239 20.202 −11.735 −12.619 1.00 85.43 O ATOM 1811 CE2 TYR A 239 18.970 −10.991 −14.536 1.00 75.91 C ATOM 1812 CD2 TYR A 239 18.932 −10.696 −15.885 1.00 75.32 C ATOM 1813 C TYR A 239 21.825 −8.852 −17.948 1.00 77.25 C ATOM 1814 O TYR A 239 22.776 −8.989 −18.723 1.00 77.90 O ATOM 1815 N HIS A 240 21.920 −8.512 −16.676 1.00 79.22 N ATOM 1816 CA HIS A 240 23.177 −8.271 −16.014 1.00 81.11 C ATOM 1817 CB HIS A 240 23.560 −6.816 −16.049 1.00 74.91 C ATOM 1818 CG HIS A 240 23.759 −6.278 −17.421 1.00 78.52 C ATOM 1819 ND1 HIS A 240 24.938 −5.701 −17.826 1.00 81.06 N ATOM 1820 CE1 HIS A 240 24.822 −5.296 −19.074 1.00 82.59 C ATOM 1821 NE2 HIS A 240 23.610 −5.597 −19.496 1.00 83.12 N ATOM 1822 CD2 HIS A 240 22.927 −6.215 −18.482 1.00 82.63 C ATOM 1823 C HIS A 240 22.997 −8.679 −14.582 1.00 89.26 C ATOM 1824 O HIS A 240 21.895 −8.706 −14.078 1.00 95.63 O ATOM 1825 N ASN A 241 24.096 −9.009 −13.937 1.00 94.35 N ATOM 1826 CA ASN A 241 24.117 −9.398 −12.546 1.00 91.07 C ATOM 1827 CB ASN A 241 23.582 −10.793 −12.312 1.00 85.20 C ATOM 1828 CG ASN A 241 22.757 −10.883 −11.049 1.00 79.72 C ATOM 1829 OD1 ASN A 241 23.070 −10.249 −10.056 1.00 82.87 O ATOM 1830 ND2 ASN A 241 21.692 −11.665 −11.087 1.00 73.92 N ATOM 1831 C ASN A 241 25.573 −9.255 −12.228 1.00 97.02 C ATOM 1832 O ASN A 241 26.337 −8.902 −13.119 1.00 98.08 O ATOM 1833 N GLY A 242 25.983 −9.516 −10.997 1.00 106.23 N ATOM 1834 CA GLY A 242 27.372 −9.283 −10.664 1.00 111.97 C ATOM 1835 C GLY A 242 28.295 −10.038 −11.584 1.00 119.58 C ATOM 1836 O GLY A 242 29.229 −9.437 −12.123 1.00 117.31 O ATOM 1837 N ASP A 243 28.040 −11.318 −11.811 1.00 122.19 N ATOM 1838 CA ASP A 243 28.887 −12.039 −12.746 1.00 119.91 C ATOM 1839 CB ASP A 243 29.917 −12.932 −12.066 1.00 118.93 C ATOM 1840 CG ASP A 243 31.295 −12.282 −12.027 1.00 116.30 C ATOM 1841 OD1 ASP A 243 31.460 −11.217 −12.659 1.00 113.12 O ATOM 1842 OD2 ASP A 243 32.213 −12.826 −11.375 1.00 105.81 O ATOM 1843 C ASP A 243 28.144 −12.717 −13.866 1.00 115.09 C ATOM 1844 O ASP A 243 28.704 −12.939 −14.926 1.00 114.47 O ATOM 1845 N LYS A 244 26.879 −13.038 −13.643 1.00 111.55 N ATOM 1846 CA LYS A 244 26.107 −13.671 −14.696 1.00 107.21 C ATOM 1847 CB LYS A 244 24.862 −14.380 −14.182 1.00 105.27 C ATOM 1848 CG LYS A 244 23.913 −14.775 −15.297 1.00 108.33 C ATOM 1849 CD LYS A 244 23.081 −15.989 −14.949 1.00 109.58 C ATOM 1850 CE LYS A 244 23.546 −17.193 −15.739 1.00 109.09 C ATOM 1851 NZ LYS A 244 23.599 −16.901 −17.196 1.00 112.67 N ATOM 1852 C LYS A 244 25.734 −12.622 −15.692 1.00 102.46 C ATOM 1853 O LYS A 244 25.722 −11.446 −15.385 1.00 106.47 O ATOM 1854 N TYR A 245 25.458 −13.052 −16.903 1.00 95.33 N ATOM 1855 CA TYR A 245 25.080 −12.119 −17.924 1.00 94.94 C ATOM 1856 CB TYR A 245 26.352 −11.401 −18.361 1.00 91.35 C ATOM 1857 CG TYR A 245 26.333 −10.575 −19.626 1.00 94.57 C ATOM 1858 CD1 TYR A 245 25.707 −11.004 −20.777 1.00 97.40 C ATOM 1859 CE1 TYR A 245 25.723 −10.246 −21.924 1.00 101.55 C ATOM 1860 CZ TYR A 245 26.402 −9.067 −21.940 1.00 100.84 C ATOM 1861 OH TYR A 245 26.429 −8.313 −23.079 1.00 99.41 O ATOM 1862 CE2 TYR A 245 27.051 −8.633 −20.824 1.00 99.38 C ATOM 1863 CD2 TYR A 245 27.024 −9.391 −19.682 1.00 97.23 C ATOM 1864 C TYR A 245 24.457 −12.881 −19.066 1.00 99.69 C ATOM 1865 O TYR A 245 24.669 −14.071 −19.218 1.00 109.80 O ATOM 1866 N LEU A 246 23.701 −12.173 −19.887 1.00 99.49 N ATOM 1867 CA LEU A 246 23.153 −12.745 −21.130 1.00 90.80 C ATOM 1868 CB LEU A 246 21.827 −13.457 −20.890 1.00 89.74 C ATOM 1869 CG LEU A 246 21.829 −14.854 −20.288 1.00 96.35 C ATOM 1870 CD1 LEU A 246 22.772 −15.011 −19.091 1.00 101.29 C ATOM 1871 CD2 LEU A 246 20.391 −15.194 −19.910 1.00 97.73 C ATOM 1872 C LEU A 246 22.918 −11.571 −22.050 1.00 83.97 C ATOM 1873 O LEU A 246 23.105 −10.417 −21.673 1.00 85.61 O ATOM 1874 N ALA A 247 22.508 −11.867 −23.264 1.00 78.33 N ATOM 1875 CA ALA A 247 22.250 −10.836 −24.244 1.00 73.14 C ATOM 1876 CB ALA A 247 23.556 −10.172 −24.669 1.00 68.67 C ATOM 1877 C ALA A 247 21.533 −11.509 −25.415 1.00 72.46 C ATOM 1878 O ALA A 247 21.678 −12.716 −25.625 1.00 69.63 O ATOM 1879 N ILE A 248 20.709 −10.734 −26.112 1.00 73.59 N ATOM 1880 CA ILE A 248 19.956 −11.195 −27.280 1.00 74.30 C ATOM 1881 CB ILE A 248 18.604 −11.845 −26.897 1.00 72.03 C ATOM 1882 CG1 ILE A 248 17.746 −10.836 −26.139 1.00 73.84 C ATOM 1883 CD1 ILE A 248 16.304 −11.258 −26.046 1.00 77.81 C ATOM 1884 CG2 ILE A 248 18.746 −13.107 −26.054 1.00 68.12 C ATOM 1885 C ILE A 248 19.643 −10.011 −28.222 1.00 77.82 C ATOM 1886 O ILE A 248 19.700 −8.827 −27.831 1.00 75.91 O ATOM 1887 N ALA 249 19.261 −10.354 −29.446 1.00 79.83 N ATOM 1888 CA ALA 249 18.871 −9.369 −30.448 1.00 81.16 C ATOM 1889 CB ALA A 249 20.096 −8.976 −31.273 1.00 81.04 C ATOM 1890 C ALA A 249 17.756 −9.910 −31.359 1.00 82.46 C ATOM 1891 O ALA A 249 17.832 −9.755 −32.577 1.00 85.07 O ATOM 1892 N PRO A 250 16.704 −10.530 −30.782 1.00 81.27 N ATOM 1893 CA PRO A 250 15.710 −11.221 −31.627 1.00 83.45 C ATOM 1894 CB PRO A 250 14.509 −11.424 −30.693 1.00 81.50 C ATOM 1895 CG PRO A 250 14.824 −10.630 −29.450 1.00 78.96 C ATOM 1896 CD PRO A 250 16.309 −10.546 −29.368 1.00 77.21 C ATOM 1897 C PRO A 250 15.271 −10.427 −32.857 1.00 87.65 C ATOM 1898 O PRO A 250 15.156 −9.194 −32.792 1.00 77.75 O ATOM 1899 N PRO A 251 14.958 −11.137 −33.959 1.00 98.36 N ATOM 1900 CA PRO A 251 14.647 −10.391 −35.185 1.00 96.16 C ATOM 1901 CB PRO A 251 14.357 −11.510 −36.217 1.00 91.52 C ATOM 1902 CG PRO A 251 13.903 −12.689 −35.411 1.00 97.09 C ATOM 1903 CD PRO A 251 14.420 −12.522 −33.994 1.00 99.81 C ATOM 1904 C PRO A 251 13.431 −9.435 −34.999 1.00 95.36 C ATOM 1905 O PRO A 251 13.368 −8.354 −35.631 1.00 95.66 O ATOM 1906 N ILE A 252 12.513 −9.882 −34.168 1.00 89.79 N ATOM 1907 CA ILE A 252 11.230 −9.261 −33.962 1.00 80.94 C ATOM 1908 CB ILE A 252 10.400 −10.226 −33.108 1.00 78.37 C ATOM 1909 CG1 ILE A 252 8.980 −10.321 −33.604 1.00 77.26 C ATOM 1910 CD1 ILE A 252 8.334 −11.614 −33.192 1.00 78.03 C ATOM 1911 CG2 ILE A 252 10.504 −9.916 −31.630 1.00 81.21 C ATOM 1912 C ILE A 252 11.136 −7.830 −33.454 1.00 79.27 C ATOM 1913 O ILE A 252 10.343 −7.068 −33.969 1.00 79.31 O ATOM 1914 N ILE A 253 11.919 −7.457 −32.457 1.00 74.03 N ATOM 1915 CA ILE A 253 11.854 −6.096 −31.953 1.00 73.90 C ATOM 1916 CB ILE A 253 12.482 −5.953 −30.583 1.00 73.12 C ATOM 1917 CG1 ILE A 253 13.989 −6.055 −30.687 1.00 77.41 C ATOM 1918 CD1 ILE A 253 14.711 −5.403 −29.534 1.00 79.21 C ATOM 1919 CG2 ILE A 253 11.925 −7.013 −29.673 1.00 71.22 C ATOM 1920 C ILE A 253 12.326 −4.974 −32.862 1.00 76.90 C ATOM 1921 O ILE A 253 11.723 −3.915 −32.886 1.00 79.25 O ATOM 1922 N LYS A 254 13.401 −5.177 −33.612 1.00 86.68 N ATOM 1923 CA LYS A 254 13.889 −4.119 −34.481 1.00 87.21 C ATOM 1924 CB LYS A 254 15.119 −4.592 −35.228 1.00 83.13 C ATOM 1925 C LYS A 254 12.776 −3.912 −35.453 1.00 87.24 C ATOM 1926 O LYS A 254 12.341 −4.839 −36.098 1.00 73.29 O ATOM 1927 N GLN A 255 12.317 −2.687 −35.548 1.00 91.09 N ATOM 1928 CA GLN A 255 11.198 −2.355 −36.387 1.00 89.38 C ATOM 1929 CB GLN A 255 10.075 −3.361 −36.194 1.00 91.56 C ATOM 1930 CG GLN A 255 9.940 −4.426 −37.254 1.00 94.28 C ATOM 1931 CD GLN A 255 9.024 −4.015 −38.377 1.00 97.03 C ATOM 1932 OE1 GLN A 255 7.970 −4.610 −38.579 1.00 89.06 O ATOM 1933 NE2 GLN A 255 9.422 −2.995 −39.118 1.00 94.81 N ATOM 1934 C GLN A 255 10.814 −1.109 −35.682 1.00 88.76 C ATOM 1935 O GLN A 255 10.868 −0.017 −36.219 1.00 84.62 O ATOM 1936 N SER A 256 10.419 −1.307 −34.434 1.00 93.29 N ATOM 1937 CA SER A 256 10.037 −0.223 −33.565 1.00 91.41 C ATOM 1938 CB SER A 256 8.533 −0.120 −33.406 1.00 97.34 C ATOM 1939 OG SER A 256 8.229 1.042 −32.677 1.00 87.58 O ATOM 1940 C SER A 256 10.665 −0.413 −32.217 1.00 73.80 C ATOM 1941 O SER A 256 10.970 −1.508 −31.802 1.00 70.17 O ATOM 1942 N THR A 257 10.842 0.708 −31.562 1.00 62.60 N ATOM 1943 CA THR A 257 11.439 0.859 −30.236 1.00 65.20 C ATOM 1944 CB THR A 257 11.833 2.343 −30.026 1.00 66.31 C ATOM 1945 OG1 THR A 257 12.154 2.958 −31.298 1.00 65.61 O ATOM 1946 CG2 THR A 257 12.959 2.513 −29.010 1.00 65.45 C ATOM 1947 C THR A 257 10.501 0.460 −29.070 1.00 65.02 C ATOM 1948 O THR A 257 9.283 0.640 −29.141 1.00 70.51 O ATOM 1949 N ILE A 258 11.066 −0.059 −27.984 1.00 59.64 N ATOM 1950 CA ILE A 258 10.267 −0.456 −26.829 1.00 53.43 C ATOM 1951 CB ILE A 258 10.912 −1.632 −26.151 1.00 53.94 C ATOM 1952 CG1 ILE A 258 10.961 −2.798 −27.142 1.00 55.06 C ATOM 1953 CD1 ILE A 258 9.644 −3.466 −27.377 1.00 56.52 C ATOM 1954 CG2 ILE A 258 10.232 −1.976 −24.829 1.00 53.73 C ATOM 1955 C ILE A 258 10.191 0.696 −25.858 1.00 53.48 C ATOM 1956 O ILE A 258 11.167 1.298 −25.539 1.00 53.51 O ATOM 1957 N VAL A 259 9.015 1.044 −25.392 1.00 57.12 N ATOM 1958 CA VAL A 259 8.894 2.242 −24.556 1.00 55.31 C ATOM 1959 CB VAL A 259 8.224 3.394 −25.346 1.00 59.28 C ATOM 1960 CG1 VAL A 259 9.125 3.857 −26.478 1.00 57.96 C ATOM 1961 CG2 VAL A 259 6.840 2.992 −25.884 1.00 62.80 C ATOM 1962 C VAL A 259 8.176 2.053 −23.234 1.00 49.55 C ATOM 1963 O VAL A 259 8.229 2.956 −22.430 1.00 46.77 O ATOM 1964 N CYS A 260 7.511 0.918 −23.040 1.00 46.23 N ATOM 1965 CA CYS A 260 6.938 0.565 −21.769 1.00 51.57 C ATOM 1966 CB CYS A 260 5.492 1.059 −21.665 1.00 52.53 C ATOM 1967 SG CYS A 260 4.293 0.521 −22.922 1.00 51.40 S ATOM 1968 C CYS A 260 7.002 −0.937 −21.510 1.00 55.82 C ATOM 1969 O CYS A 260 6.987 −1.724 −22.454 1.00 60.20 O ATOM 1970 N HIS A 261 7.063 −1.308 −20.228 1.00 55.87 N ATOM 1971 CA HIS A 261 7.179 −2.685 −19.788 1.00 55.28 C ATOM 1972 CB HIS A 261 8.606 −2.948 −19.376 1.00 60.01 C ATOM 1973 CG HIS A 261 8.977 −2.375 −18.028 1.00 68.79 C ATOM 1974 ND1 HIS A 261 8.848 −3.090 −16.851 1.00 70.72 N ATOM 1975 CE1 HIS A 261 9.261 −2.346 −15.836 1.00 72.74 C ATOM 1976 NE2 HIS A 261 9.667 −1.181 −16.312 1.00 73.47 N ATOM 1977 CD2 HIS A 261 9.496 −1.168 −17.677 1.00 71.62 C ATOM 1978 C HIS A 261 6.324 −2.933 −18.567 1.00 54.59 C ATOM 1979 O HIS A 261 6.029 −2.027 −17.867 1.00 57.69 O ATOM 1980 N ASN A 262 5.992 −4.166 −18.251 1.00 57.51 N ATOM 1981 CA ASN A 262 5.369 −4.448 −16.980 1.00 59.13 C ATOM 1982 CB ASN A 262 3.881 −4.248 −17.059 1.00 63.36 C ATOM 1983 CG ASN A 262 3.280 −4.109 −15.687 1.00 69.34 C ATOM 1984 OD1 ASN A 262 3.656 −3.179 −14.913 1.00 66.22 O ATOM 1985 ND2 ASN A 262 2.398 −5.045 −15.336 1.00 67.95 N ATOM 1986 C ASN A 262 5.571 −5.838 −16.536 1.00 58.26 C ATOM 1987 O ASN A 262 5.435 −6.733 −17.331 1.00 67.74 O ATOM 1988 N ARG A 263 5.825 −6.039 −15.258 1.00 58.05 N ATOM 1989 CA ARG A 263 6.072 −7.386 −14.719 1.00 59.07 C ATOM 1990 CB ARG A 263 6.757 −7.281 −13.364 1.00 60.05 C ATOM 1991 CG ARG A 263 7.243 −8.606 −12.809 1.00 64.20 C ATOM 1992 CD ARG A 263 6.957 −8.649 −11.336 1.00 65.99 C ATOM 1993 NE ARG A 263 7.688 −7.569 −10.694 1.00 68.78 N ATOM 1994 CZ ARG A 263 7.400 −7.079 −9.504 1.00 70.85 C ATOM 1995 NH1 ARG A 263 6.372 −7.552 −8.817 1.00 74.19 N ATOM 1996 NH2 ARG A 263 8.139 −6.103 −9.002 1.00 73.91 N ATOM 1997 C ARG A 263 4.797 −8.245 −14.569 1.00 56.59 C ATOM 1998 O ARG A 263 3.895 −7.902 −13.817 1.00 53.70 O ATOM 1999 N VAL A 264 4.772 −9.405 −15.219 1.00 55.24 N ATOM 2000 CA VAL A 264 3.584 −10.213 −15.227 1.00 56.33 C ATOM 2001 CB VAL A 264 3.504 −11.084 −16.467 1.00 57.34 C ATOM 2002 CG1 VAL A 264 2.196 −11.875 −16.482 1.00 56.82 C ATOM 2003 CG2 VAL A 264 3.606 −10.193 −17.699 1.00 60.00 C ATOM 2004 C VAL A 264 3.400 −11.062 −13.989 1.00 59.07 C ATOM 2005 O VAL A 264 2.259 −11.233 −13.581 1.00 62.61 O ATOM 2006 N ASP A 265 4.485 −11.578 −13.433 1.00 64.02 N ATOM 2007 CA ASP A 265 4.429 −12.409 −12.251 1.00 69.84 C ATOM 2008 CB ASP A 265 4.704 −13.861 −12.593 1.00 76.86 C ATOM 2009 CG ASP A 265 6.029 −14.059 −13.251 1.00 85.65 C ATOM 2010 OD1 ASP A 265 7.033 −13.530 −12.753 1.00 86.26 O ATOM 2011 OD2 ASP A 265 6.078 −14.769 −14.267 1.00 83.37 O ATOM 2012 C ASP A 265 5.400 −11.936 −11.206 1.00 66.80 C ATOM 2013 O ASP A 265 6.441 −11.388 −11.516 1.00 65.56 O ATOM 2014 N PRO A 266 5.019 −12.191 −9.902 1.00 64.96 N ATOM 2015 CA PRO A 266 5.961 −11.708 −8.888 1.00 66.82 C ATOM 2016 CB PRO A 266 5.349 −12.171 −7.585 1.00 64.75 C ATOM 2017 CG PRO A 266 3.909 −12.209 −7.854 1.00 64.74 C ATOM 2018 CD PRO A 266 3.896 −12.900 −9.156 1.00 62.18 C ATOM 2019 C PRO A 266 7.275 −12.380 −9.070 1.00 71.28 C ATOM 2020 O PRO A 266 8.315 −11.870 −8.731 1.00 74.12 O ATOM 2021 N ASN A 267 7.198 −13.557 −9.637 1.00 80.76 N ATOM 2022 CA ASN A 267 8.325 −14.393 −9.887 1.00 86.22 C ATOM 2023 CB ASN A 267 7.817 −15.639 −10.595 1.00 91.48 C ATOM 2024 CG ASN A 267 8.906 −16.615 −10.886 1.00 101.35 C ATOM 2025 OD1 ASN A 267 10.070 −16.293 −10.739 1.00 116.70 O ATOM 2026 ND2 ASN A 267 8.541 −17.818 −11.302 1.00 102.80 N ATOM 2027 C ASN A 267 9.313 −13.644 −10.755 1.00 87.48 C ATOM 2028 O ASN A 267 10.508 −13.785 −10.577 1.00 87.92 O ATOM 2029 N GLY A 268 8.827 −12.831 −11.685 1.00 85.29 N ATOM 2030 CA GLY A 268 9.727 −12.102 −12.559 1.00 76.97 C ATOM 2031 C GLY A 268 10.021 −12.933 −13.778 1.00 77.60 C ATOM 2032 O GLY A 268 10.955 −12.704 −14.508 1.00 72.39 O ATOM 2033 N SER A 269 9.197 −13.938 −13.969 1.00 78.68 N ATOM 2034 CA SER A 269 9.322 −14.893 −15.076 1.00 81.52 C ATOM 2035 CB SER A 269 8.375 −16.067 −14.919 1.00 86.32 C ATOM 2036 OG SER A 269 8.821 −16.893 −13.883 1.00 99.32 O ATOM 2037 C SER A 269 9.003 −14.272 −16.399 1.00 78.84 C ATOM 2038 O SER A 269 9.665 −14.546 −17.395 1.00 77.83 O ATOM 2039 N ARG A 270 7.948 −13.473 −16.410 1.00 75.92 N ATOM 2040 CA ARG A 270 7.481 −12.851 −17.632 1.00 71.81 C ATOM 2041 CB ARG A 270 6.174 −13.536 −18.022 1.00 72.23 C ATOM 2042 CG ARG A 270 6.306 −15.045 −18.163 1.00 72.89 C ATOM 2043 CD ARG A 270 5.019 −15.670 −18.701 1.00 77.75 C ATOM 2044 NE ARG A 270 4.045 −15.883 −17.634 1.00 82.35 N ATOM 2045 CZ ARG A 270 2.712 −15.790 −17.738 1.00 89.94 C ATOM 2046 NH1 ARG A 270 2.091 −15.468 −18.869 1.00 88.74 N ATOM 2047 NH2 ARG A 270 1.969 −16.008 −16.660 1.00 98.50 N ATOM 2048 C ARG A 270 7.344 −11.309 −17.496 1.00 64.28 C ATOM 2049 O ARG A 270 7.090 −10.792 −16.397 1.00 66.03 O ATOM 2050 N TYR A 271 7.574 −10.593 −18.598 1.00 56.79 N ATOM 2051 CA TYR A 271 7.312 −9.155 −18.701 1.00 54.83 C ATOM 2052 CB TYR A 271 8.624 −8.395 −18.776 1.00 54.49 C ATOM 2053 CG TYR A 271 9.255 −8.375 −17.387 1.00 60.18 C ATOM 2054 CD1 TYR A 271 9.949 −9.483 −16.897 1.00 64.17 C ATOM 2055 CE1 TYR A 271 10.482 −9.503 −15.621 1.00 64.28 C ATOM 2056 CZ TYR A 271 10.319 −8.424 −14.815 1.00 65.48 C ATOM 2057 OH TYR A 271 10.856 −8.448 −13.556 1.00 66.15 O ATOM 2058 CE2 TYR A 271 9.621 −7.317 −15.265 1.00 65.35 C ATOM 2059 CD2 TYR A 271 9.083 −7.301 −16.531 1.00 61.02 C ATOM 2060 C TYR A 271 6.416 −8.880 −19.887 1.00 54.74 C ATOM 2061 O TYR A 271 6.375 −9.671 −20.803 1.00 56.76 O ATOM 2062 N LEU A 272 5.618 −7.813 −19.849 1.00 53.22 N ATOM 2063 CA LEU A 272 4.940 −7.334 −21.076 1.00 50.49 C ATOM 2064 CB LEU A 272 3.533 −6.865 −20.808 1.00 47.96 C ATOM 2065 CG LEU A 272 2.701 −8.064 −20.383 1.00 49.83 C ATOM 2066 CD1 LEU A 272 1.376 −7.669 −19.782 1.00 50.22 C ATOM 2067 CD2 LEU A 272 2.423 −8.958 −21.552 1.00 54.51 C ATOM 2068 C LEU A 272 5.797 −6.219 −21.602 1.00 48.76 C ATOM 2069 O LEU A 272 6.361 −5.512 −20.789 1.00 46.98 O ATOM 2070 N LEU A 273 5.990 −6.134 −22.928 1.00 45.55 N ATOM 2071 CA LEU A 273 6.634 −4.983 −23.521 1.00 44.98 C ATOM 2072 CB LEU A 273 7.937 −5.319 −24.184 1.00 45.54 C ATOM 2073 CG LEU A 273 8.955 −6.015 −23.313 1.00 48.64 C ATOM 2074 CD1 LEU A 273 10.265 −6.170 −24.070 1.00 49.87 C ATOM 2075 CD2 LEU A 273 9.192 −5.278 −22.016 1.00 50.27 C ATOM 2076 C LEU A 273 5.753 −4.289 −24.542 1.00 48.05 C ATOM 2077 O LEU A 273 4.915 −4.900 −25.249 1.00 46.24 O ATOM 2078 N GLY A 274 5.990 −2.987 −24.618 1.00 47.53 N ATOM 2079 CA GLY A 274 5.235 −2.135 −25.437 1.00 48.02 C ATOM 2080 C GLY A 274 6.141 −1.426 −26.388 1.00 50.64 C ATOM 2081 O GLY A 274 7.135 −0.834 −26.024 1.00 52.80 O ATOM 2082 N ASP A 275 5.697 −1.462 −27.618 1.00 55.65 N ATOM 2083 CA ASP A 275 6.284 −0.851 −28.783 1.00 55.34 C ATOM 2084 CB ASP A 275 5.585 −1.605 −29.887 1.00 63.23 C ATOM 2085 CG ASP A 275 6.138 −1.373 −31.184 1.00 77.21 C ATOM 2086 OD1 ASP A 275 7.303 −0.925 −31.265 1.00 93.49 O ATOM 2087 OD2 ASP A 275 5.386 −1.674 −32.141 1.00 91.57 O ATOM 2088 C ASP A 275 5.865 0.622 −28.850 1.00 50.56 C ATOM 2089 O ASP A 275 4.970 1.022 −28.144 1.00 55.88 O ATOM 2090 N MET A 276 6.454 1.425 −29.724 0.50 42.83 N ATOM 2091 CA MET A 276 6.028 2.797 −29.914 0.50 35.48 C ATOM 2092 CB MET A 276 7.210 3.610 −30.399 0.50 31.52 C ATOM 2093 CG MET A 276 6.989 5.098 −30.548 0.50 29.79 C ATOM 2094 SD MET A 276 8.611 5.856 −30.443 0.50 26.47 S ATOM 2095 CE MET A 276 9.281 4.458 −29.640 0.50 27.32 C ATOM 2096 C MET A 276 4.920 2.850 −30.915 0.50 36.18 C ATOM 2097 O MET A 276 4.430 3.887 −31.180 0.50 35.43 O ATOM 2098 N GLU A 277 4.532 1.725 −31.483 1.00 41.41 N ATOM 2099 CA GLU A 277 3.547 1.636 −32.625 1.00 49.21 C ATOM 2100 CB GLU A 277 4.186 1.242 −34.029 1.00 56.40 C ATOM 2101 CG GLU A 277 5.427 1.970 −34.624 1.00 65.77 C ATOM 2102 CD GLU A 277 5.874 1.499 −36.064 1.00 73.16 C ATOM 2103 OE1 GLU A 277 5.917 0.264 −36.360 1.00 76.67 O ATOM 2104 OE2 GLU A 277 6.222 2.375 −36.913 1.00 73.60 O ATOM 2105 C GLU A 277 2.393 0.588 −32.411 1.00 47.51 C ATOM 2106 O GLU A 277 1.583 0.383 −33.353 1.00 45.06 O ATOM 2107 N GLY A 278 2.308 −0.073 −31.244 1.00 43.04 N ATOM 2108 CA GLY A 278 1.236 −1.055 −31.011 1.00 42.21 C ATOM 2109 C GLY A 278 1.666 −2.516 −30.755 1.00 40.44 C ATOM 2110 O GLY A 278 0.870 −3.331 −30.271 1.00 40.92 O ATOM 2111 N ARG A 279 2.889 −2.885 −31.071 0.50 35.36 N ATOM 2112 CA ARG A 279 3.245 −4.209 −30.752 0.50 33.66 C ATOM 2113 CB ARG A 279 4.506 −4.619 −31.459 0.50 31.88 C ATOM 2114 CG ARG A 279 4.346 −4.591 −32.958 0.50 29.07 C ATOM 2115 CD ARG A 279 5.678 −4.664 −33.603 0.50 27.42 C ATOM 2116 NE ARG A 279 5.522 −4.338 −34.975 0.50 27.35 N ATOM 2117 CZ ARG A 279 5.870 −3.161 −35.466 0.50 28.50 C ATOM 2118 NH1 ARG A 279 6.392 −2.256 −34.661 0.50 28.84 N ATOM 2119 NH2 ARG A 279 5.713 −2.873 −36.755 0.50 28.28 N ATOM 2120 C ARG A 279 3.300 −4.394 −29.252 0.50 35.88 C ATOM 2121 O ARG A 279 3.638 −3.510 −28.499 0.50 33.93 O ATOM 2122 N LEU A 280 2.831 −5.558 −28.855 1.00 42.22 N ATOM 2123 CA LEU A 280 2.852 −6.078 −27.477 1.00 49.22 C ATOM 2124 CB LEU A 280 1.416 −6.184 −26.915 1.00 48.50 C ATOM 2125 CG LEU A 280 1.186 −6.754 −25.500 1.00 47.45 C ATOM 2126 CD1 LEU A 280 1.801 −5.859 −24.425 1.00 46.61 C ATOM 2127 CD2 LEU A 280 −0.295 −6.989 −25.228 1.00 46.70 C ATOM 2128 C LEU A 280 3.532 −7.490 −27.416 1.00 56.12 C ATOM 2129 O LEU A 280 3.034 −8.496 −27.953 1.00 56.61 O ATOM 2130 N PHE A 281 4.656 −7.546 −26.721 1.00 61.96 N ATOM 2131 CA PHE A 281 5.441 −8.749 −26.581 1.00 64.26 C ATOM 2132 CB PHE A 281 6.904 −8.446 −26.897 1.00 69.09 C ATOM 2133 CG PHE A 281 7.139 −7.772 −28.210 1.00 71.68 C ATOM 2134 CD1 PHE A 281 7.001 −6.404 −28.327 1.00 71.30 C ATOM 2135 CE1 PHE A 281 7.243 −5.780 −29.526 1.00 70.25 C ATOM 2136 CZ PHE A 281 7.637 −6.510 −30.609 1.00 68.33 C ATOM 2137 CE2 PHE A 281 7.790 −7.867 −30.505 1.00 68.62 C ATOM 2138 CD2 PHE A 281 7.568 −8.496 −29.308 1.00 71.15 C ATOM 2139 C PHE A 281 5.451 −9.228 −25.128 1.00 67.12 C ATOM 2140 O PHE A 281 5.436 −8.390 −24.196 1.00 69.53 O ATOM 2141 N MET A 282 5.525 −10.559 −24.945 1.00 63.28 N ATOM 2142 CA MET A 282 6.035 −11.145 −23.726 1.00 56.46 C ATOM 2143 CB MET A 282 5.478 −12.478 −23.498 1.00 58.19 C ATOM 2144 CG MET A 282 5.557 −12.846 −22.059 1.00 64.37 C ATOM 2145 SD MET A 282 3.833 −12.722 −21.601 1.00 77.19 S ATOM 2146 CE MET A 282 3.450 −14.448 −22.033 1.00 74.00 C ATOM 2147 C MET A 282 7.501 −11.358 −23.899 1.00 53.16 C ATOM 2148 O MET A 282 7.958 −11.528 −25.012 1.00 49.66 O ATOM 2149 N LEU A 283 8.228 −11.328 −22.798 1.00 53.94 N ATOM 2150 CA LEU A 283 9.655 −11.613 −22.755 1.00 56.49 C ATOM 2151 CB LEU A 283 10.490 −10.337 −22.565 1.00 58.50 C ATOM 2152 CG LEU A 283 11.776 −10.345 −21.695 1.00 60.95 C ATOM 2153 CD1 LEU A 283 12.788 −11.361 −22.189 1.00 63.99 C ATOM 2154 CD2 LEU A 283 12.474 −8.983 −21.622 1.00 61.72 C ATOM 2155 C LEU A 283 9.742 −12.489 −21.556 1.00 59.31 C ATOM 2156 O LEU A 283 9.292 −12.066 −20.513 1.00 61.42 O ATOM 2157 N LEU A 284 10.305 −13.698 −21.696 1.00 66.28 N ATOM 2158 CA LEU A 284 10.276 −14.722 −20.633 1.00 64.05 C ATOM 2159 CB LEU A 284 9.635 −16.007 −21.071 1.00 58.25 C ATOM 2160 CG LEU A 284 8.310 −15.668 −21.707 1.00 59.04 C ATOM 2161 CD1 LEU A 284 8.429 −15.362 −23.206 1.00 56.74 C ATOM 2162 CD2 LEU A 284 7.363 −16.810 −21.435 1.00 62.58 C ATOM 2163 C LEU A 284 11.658 −15.043 −20.268 1.00 68.90 C ATOM 2164 O LEU A 284 12.505 −15.179 −21.164 1.00 70.06 O ATOM 2165 N LEU A 285 11.850 −15.204 −18.956 1.00 74.69 N ATOM 2166 CA LEU A 285 13.147 −15.442 −18.344 1.00 78.20 C ATOM 2167 CB LEU A 285 13.316 −14.597 −17.084 1.00 78.39 C ATOM 2168 CG LEU A 285 13.239 −13.071 −17.202 1.00 74.72 C ATOM 2169 CD1 LEU A 285 14.085 −12.460 −16.098 1.00 73.80 C ATOM 2170 CD2 LEU A 285 13.727 −12.557 −18.547 1.00 74.39 C ATOM 2171 C LEU A 285 13.284 −16.916 −18.024 1.00 80.97 C ATOM 2172 O LEU A 285 12.714 −17.434 −17.036 1.00 78.99 O ATOM 2173 N GLU A 286 14.080 −17.565 −18.869 1.00 84.80 N ATOM 2174 CA GLU A 286 14.082 −18.995 −18.969 1.00 86.31 C ATOM 2175 CB GLU A 286 14.281 −19.413 −20.438 1.00 86.69 C ATOM 2176 CG GLU A 286 13.240 −18.681 −21.311 1.00 91.55 C ATOM 2177 CD GLU A 286 12.873 −19.329 −22.652 1.00 94.89 C ATOM 2178 OE1 GLU A 286 13.745 −19.398 −23.553 1.00 96.88 O ATOM 2179 OE2 GLU A 286 11.684 −19.707 −22.831 1.00 89.36 O ATOM 2180 C GLU A 286 15.079 −19.559 −17.952 1.00 86.16 C ATOM 2181 O GLU A 286 16.220 −19.105 −17.847 1.00 76.19 O ATOM 2182 N LYS A 287 14.568 −20.512 −17.171 1.00 92.29 N ATOM 2183 CA LYS A 287 15.277 −21.192 −16.096 1.00 94.26 C ATOM 2184 CB LYS A 287 14.761 −20.698 −14.732 1.00 94.49 C ATOM 2185 CG LYS A 287 13.242 −20.674 −14.569 1.00 99.99 C ATOM 2186 CD LYS A 287 12.833 −20.077 −13.226 1.00 107.17 C ATOM 2187 CE LYS A 287 11.515 −19.301 −13.278 1.00 114.07 C ATOM 2188 NZ LYS A 287 10.324 −20.168 −13.512 1.00 117.26 N ATOM 2189 C LYS A 287 15.079 −22.711 −16.297 1.00 91.90 C ATOM 2190 O LYS A 287 14.945 −23.487 −15.351 1.00 86.91 O ATOM 2191 N THR A 296 19.115 −22.411 −13.834 1.00 89.30 N ATOM 2192 CA THR A 296 18.238 −21.316 −13.446 1.00 104.34 C ATOM 2193 CB THR A 296 18.794 −20.519 −12.253 1.00 99.57 C ATOM 2194 OG1 THR A 296 20.059 −19.949 −12.603 1.00 91.91 O ATOM 2195 CG2 THR A 296 18.947 −21.410 −11.045 1.00 90.65 C ATOM 2196 C THR A 296 17.951 −20.343 −14.589 1.00 111.84 C ATOM 2197 O THR A 296 17.016 −20.545 −15.371 1.00 127.83 O ATOM 2198 N LEU A 297 18.745 −19.282 −14.682 1.00 106.04 N ATOM 2199 CA LEU A 297 18.531 −18.303 −15.727 1.00 104.47 C ATOM 2200 CB LEU A 297 19.002 −16.937 −15.266 1.00 111.66 C ATOM 2201 CG LEU A 297 18.959 −15.897 −16.377 1.00 119.13 C ATOM 2202 CD1 LEU A 297 17.669 −15.994 −17.161 1.00 120.62 C ATOM 2203 CD2 LEU A 297 19.106 −14.509 −15.801 1.00 123.16 C ATOM 2204 C LEU A 297 19.207 −18.666 −17.029 1.00 98.85 C ATOM 2205 O LEU A 297 20.201 −18.066 −17.403 1.00 95.36 O ATOM 2206 N LYS A 298 18.675 −19.656 −17.722 1.00 94.62 N ATOM 2207 CA LYS A 298 19.286 −20.069 −18.968 1.00 92.33 C ATOM 2208 CB LYS A 298 18.682 −21.397 −19.442 1.00 97.79 C ATOM 2209 CG LYS A 298 19.010 −21.777 −20.879 1.00 104.02 C ATOM 2210 CD LYS A 298 19.182 −23.271 −21.065 1.00 110.76 C ATOM 2211 CE LYS A 298 19.734 −23.580 −22.447 1.00 112.36 C ATOM 2212 NZ LYS A 298 20.979 −22.816 −22.729 1.00 109.12 N ATOM 2213 C LYS A 298 19.275 −19.059 −20.096 1.00 87.79 C ATOM 2214 O LYS A 298 20.291 −18.868 −20.738 1.00 78.83 O ATOM 2215 N ASP A 299 18.148 −18.407 −20.339 1.00 89.17 N ATOM 2216 CA ASP A 299 18.089 −17.485 −21.461 1.00 87.54 C ATOM 2217 CB ASP A 299 18.153 −18.308 −22.742 1.00 88.07 C ATOM 2218 CG ASP A 299 18.857 −17.600 −23.855 1.00 86.53 C ATOM 2219 OD1 ASP A 299 19.268 −16.453 −23.663 1.00 80.29 O ATOM 2220 OD2 ASP A 299 19.007 −18.189 −24.933 1.00 91.96 O ATOM 2221 C ASP A 299 16.848 −16.622 −21.495 1.00 82.17 C ATOM 2222 O ASP A 299 16.075 −16.617 −20.551 1.00 70.86 O ATOM 2223 N LEU A 300 16.665 −15.909 −22.607 1.00 79.44 N ATOM 2224 CA LEU A 300 15.510 −14.985 −22.796 1.00 74.97 C ATOM 2225 CB LEU A 300 16.047 −13.554 −22.790 1.00 70.29 C ATOM 2226 CG LEU A 300 17.139 −13.180 −21.792 1.00 70.91 C ATOM 2227 CD1 LEU A 300 17.765 −11.825 −22.146 1.00 71.43 C ATOM 2228 CD2 LEU A 300 16.605 −13.164 −20.368 1.00 69.87 C ATOM 2229 C LEU A 300 14.708 −15.174 −24.125 1.00 74.06 C ATOM 2230 O LEU A 300 15.179 −14.691 −25.160 1.00 80.91 O ATOM 2231 N ARG A 301 13.546 −15.860 −24.142 1.00 69.27 N ATOM 2232 CA ARG A 301 12.689 −15.874 −25.391 1.00 68.37 C ATOM 2233 CB ARG A 301 11.801 −17.175 −25.625 1.00 56.23 C ATOM 2234 C ARG A 301 11.880 −14.526 −25.320 1.00 70.05 C ATOM 2235 O ARG A 301 11.771 −13.936 −24.229 1.00 60.62 O ATOM 2236 N VAL A 302 11.388 −14.058 −26.489 1.00 72.49 N ATOM 2237 CA VAL A 302 10.551 −12.851 −26.682 1.00 69.54 C ATOM 2238 CB VAL A 302 11.424 −11.707 −27.235 1.00 67.15 C ATOM 2239 CG1 VAL A 302 10.616 −10.522 −27.769 1.00 67.66 C ATOM 2240 CG2 VAL A 302 12.358 −11.237 −26.159 1.00 70.97 C ATOM 2241 C VAL A 302 9.396 −13.124 −27.679 1.00 74.17 C ATOM 2242 O VAL A 302 9.580 −12.959 −28.876 1.00 80.43 O ATOM 2243 N GLU A 303 8.212 −13.533 −27.214 1.00 76.75 N ATOM 2244 CA GLU A 303 7.084 −13.846 −28.140 1.00 76.95 C ATOM 2245 CB GLU A 303 6.063 −14.815 −27.508 1.00 77.28 C ATOM 2246 CG GLU A 303 5.372 −15.773 −28.472 1.00 80.88 C ATOM 2247 CD GLU A 303 4.884 −17.039 −27.762 1.00 91.72 C ATOM 2248 OE1 GLU A 303 4.146 −16.936 −26.757 1.00 96.96 O ATOM 2249 OE2 GLU A 303 5.246 −18.158 −28.182 1.00 96.79 O ATOM 2250 C GLU A 303 6.430 −12.525 −28.518 1.00 72.04 C ATOM 2251 O GLU A 303 6.554 −11.567 −27.789 1.00 67.62 O ATOM 2252 N LEU A 304 5.786 −12.471 −29.678 1.00 69.02 N ATOM 2253 CA LEU A 304 5.025 −11.298 −30.081 1.00 61.81 C ATOM 2254 CB LEU A 304 5.335 −10.882 −31.515 1.00 56.81 C ATOM 2255 CG LEU A 304 4.281 −10.011 −32.211 1.00 56.12 C ATOM 2256 CD1 LEU A 304 3.924 −8.733 −31.462 1.00 57.66 C ATOM 2257 CD2 LEU A 304 4.781 −9.676 −33.591 1.00 56.56 C ATOM 2258 C LEU A 304 3.574 −11.674 −29.954 1.00 62.46 C ATOM 2259 O LEU A 304 3.059 −12.478 −30.743 1.00 61.92 O ATOM 2260 N LEU A 305 2.897 −11.048 −29.003 1.00 62.91 N ATOM 2261 CA LEU A 305 1.558 −11.489 −28.638 1.00 62.60 C ATOM 2262 CB LEU A 305 1.258 −11.169 −27.188 1.00 64.21 C ATOM 2263 CG LEU A 305 2.388 −11.464 −26.188 1.00 64.35 C ATOM 2264 CD1 LEU A 305 2.355 −10.407 −25.091 1.00 65.76 C ATOM 2265 CD2 LEU A 305 2.286 −12.861 −25.617 1.00 62.78 C ATOM 2266 C LEU A 305 0.500 −10.900 −29.554 1.00 58.33 C ATOM 2267 O LEU A 305 −0.398 −11.612 −29.945 1.00 55.91 O ATOM 2268 N GLY A 306 0.597 −9.621 −29.909 1.00 57.08 N ATOM 2269 CA GLY A 306 −0.434 −9.022 −30.797 1.00 57.84 C ATOM 2270 C GLY A 306 −0.356 −7.523 −30.972 1.00 53.59 C ATOM 2271 O GLY A 306 0.704 −6.951 −30.803 1.00 49.88 O ATOM 2272 N GLU A 307 −1.484 −6.896 −31.305 1.00 54.12 N ATOM 2273 CA GLU A 307 −1.564 −5.426 −31.468 1.00 54.40 C ATOM 2274 CB GLU A 307 −2.090 −5.027 −32.843 1.00 55.55 C ATOM 2275 CG GLU A 307 −1.145 −4.154 −33.636 1.00 61.68 C ATOM 2276 CD GLU A 307 −1.808 −3.456 −34.830 1.00 67.74 C ATOM 2277 OE1 GLU A 307 −1.013 −2.938 −35.682 1.00 74.56 O ATOM 2278 OE2 GLU A 307 −3.083 −3.415 −34.907 1.00 60.11 O ATOM 2279 C GLU A 307 −2.515 −4.831 −30.440 1.00 55.39 C ATOM 2280 O GLU A 307 −3.626 −5.343 −30.185 1.00 53.11 O ATOM 2281 N THR A 308 −2.090 −3.716 −29.866 1.00 55.33 N ATOM 2282 CA THR A 308 −2.941 −2.967 −28.949 1.00 52.95 C ATOM 2283 CB THR A 308 −2.408 −3.051 −27.488 1.00 48.95 C ATOM 2284 OG1 THR A 308 −1.057 −2.547 −27.377 1.00 43.93 O ATOM 2285 CG2 THR A 308 −2.415 −4.530 −27.046 1.00 46.96 C ATOM 2286 C THR A 308 −2.974 −1.567 −29.495 1.00 53.89 C ATOM 2287 O THR A 308 −2.275 −1.223 −30.461 1.00 56.54 O ATOM 2288 N SER A 309 −3.809 −0.763 −28.887 1.00 53.04 N ATOM 2289 CA SER A 309 −3.646 0.653 −28.980 1.00 49.81 C ATOM 2290 CB SER A 309 −4.667 1.390 −28.087 1.00 50.79 C ATOM 2291 OG SER A 309 −6.005 1.118 −28.493 1.00 52.26 O ATOM 2292 C SER A 309 −2.227 0.948 −28.520 1.00 44.51 C ATOM 2293 O SER A 309 −1.633 0.227 −27.752 1.00 40.69 O ATOM 2294 N ILE A 310 −1.728 2.052 −28.996 1.00 43.39 N ATOM 2295 CA ILE A 310 −0.359 2.435 −28.867 1.00 44.04 C ATOM 2296 CB ILE A 310 −0.133 3.666 −29.783 1.00 46.28 C ATOM 2297 CG1 ILE A 310 −0.542 3.345 −31.214 1.00 46.62 C ATOM 2298 CD1 ILE A 310 −0.619 4.569 −32.068 1.00 49.50 C ATOM 2299 CG2 ILE A 310 1.314 4.162 −29.769 1.00 47.00 C ATOM 2300 C ILE A 310 −0.167 2.795 −27.404 1.00 44.45 C ATOM 2301 O ILE A 310 −0.773 3.759 −26.871 1.00 47.31 O ATOM 2302 N ALA A 311 0.648 2.017 −26.729 1.00 44.02 N ATOM 2303 CA ALA A 311 0.613 2.033 −25.258 1.00 45.80 C ATOM 2304 CB ALA A 311 0.912 0.659 −24.681 1.00 44.81 C ATOM 2305 C ALA A 311 1.559 3.059 −24.641 1.00 47.00 C ATOM 2306 O ALA A 311 2.719 3.176 −25.045 1.00 48.42 O ATOM 2307 N GLU A 312 1.041 3.791 −23.659 1.00 46.47 N ATOM 2308 CA GLU A 312 1.839 4.654 −22.854 1.00 46.37 C ATOM 2309 CB GLU A 312 0.996 5.829 −22.408 1.00 46.43 C ATOM 2310 CG GLU A 312 1.728 6.820 −21.522 1.00 49.83 C ATOM 2311 CD GLU A 312 2.981 7.474 −22.129 1.00 53.14 C ATOM 2312 OE1 GLU A 312 3.580 8.301 −21.383 1.00 55.56 O ATOM 2313 OE2 GLU A 312 3.327 7.232 −23.324 1.00 51.85 O ATOM 2314 C GLU A 312 2.336 3.867 −21.673 1.00 48.11 C ATOM 2315 O GLU A 312 3.487 4.053 −21.179 1.00 49.71 O ATOM 2316 N CYS A 313 1.459 3.001 −21.187 1.00 46.56 N ATOM 2317 CA CYS A 313 1.751 2.298 −20.000 1.00 46.51 C ATOM 2318 CB CYS A 313 1.439 3.242 −18.854 1.00 47.48 C ATOM 2319 SG CYS A 313 −0.308 3.382 −18.417 1.00 58.25 S ATOM 2320 C CYS A 313 0.879 1.053 −20.065 1.00 46.38 C ATOM 2321 O CYS A 313 −0.155 1.078 −20.771 1.00 43.47 O ATOM 2322 N LEU A 314 1.287 −0.009 −19.352 1.00 45.18 N ATOM 2323 CA LEU A 314 0.594 −1.319 −19.368 1.00 44.86 C ATOM 2324 CB LEU A 314 1.388 −2.306 −20.196 1.00 42.07 C ATOM 2325 CG LEU A 314 1.666 −2.100 −21.683 1.00 42.47 C ATOM 2326 CD1 LEU A 314 3.026 −2.595 −22.158 1.00 42.82 C ATOM 2327 CD2 LEU A 314 0.658 −2.846 −22.519 1.00 44.07 C ATOM 2328 C LEU A 314 0.512 −1.935 −17.974 1.00 50.52 C ATOM 2329 O LEU A 314 1.470 −1.889 −17.229 1.00 58.60 O ATOM 2330 N THR A 315 −0.589 −2.565 −17.640 1.00 53.74 N ATOM 2331 CA THR A 315 −0.673 −3.202 −16.356 1.00 56.89 C ATOM 2332 CB THR A 315 −1.523 −2.388 −15.414 1.00 62.77 C ATOM 2333 OG1 THR A 315 −0.856 −1.165 −15.184 1.00 70.96 O ATOM 2334 CG2 THR A 315 −1.638 −3.062 −14.128 1.00 68.61 C ATOM 2335 C THR A 315 −1.286 −4.546 −16.537 1.00 58.81 C ATOM 2336 O THR A 315 −2.227 −4.678 −17.276 1.00 63.44 O ATOM 2337 N TYR A 316 −0.769 −5.545 −15.852 1.00 58.00 N ATOM 2338 CA TYR A 316 −1.316 −6.861 −15.971 1.00 54.77 C ATOM 2339 CB TYR A 316 −0.219 −7.897 −15.898 1.00 56.89 C ATOM 2340 CG TYR A 316 −0.756 −9.285 −15.964 1.00 60.13 C ATOM 2341 CD1 TYR A 316 −1.072 −9.855 −17.163 1.00 60.67 C ATOM 2342 CE1 TYR A 316 −1.582 −11.122 −17.233 1.00 61.37 C ATOM 2343 CZ TYR A 316 −1.779 −11.826 −16.100 1.00 61.39 C ATOM 2344 OH TYR A 316 −2.286 −13.080 −16.187 1.00 55.59 O ATOM 2345 CE2 TYR A 316 −1.473 −11.284 −14.888 1.00 60.22 C ATOM 2346 CD2 TYR A 316 −0.966 −10.016 −14.826 1.00 60.82 C ATOM 2347 C TYR A 316 −2.205 −6.989 −14.791 1.00 52.01 C ATOM 2348 O TYR A 316 −1.767 −6.830 −13.688 1.00 51.65 O ATOM 2349 N LEU A 317 −3.469 −7.262 −15.024 1.00 51.59 N ATOM 2350 CA LEU A 317 −4.417 −7.376 −13.944 1.00 55.48 C ATOM 2351 CB LEU A 317 −5.754 −6.860 −14.418 1.00 51.90 C ATOM 2352 CG LEU A 317 −5.699 −5.499 −15.044 1.00 52.56 C ATOM 2353 CD1 LEU A 317 −7.095 −5.042 −15.352 1.00 51.32 C ATOM 2354 CD2 LEU A 317 −5.056 −4.594 −14.038 1.00 51.93 C ATOM 2355 C LEU A 317 −4.678 −8.740 −13.367 1.00 63.68 C ATOM 2356 O LEU A 317 −5.373 −8.833 −12.402 1.00 65.51 O ATOM 2357 N ASP A 318 −4.150 −9.788 −13.963 1.00 74.10 N ATOM 2358 CA ASP A 318 −4.373 −11.172 −13.541 1.00 80.65 C ATOM 2359 CB ASP A 318 −4.549 −11.358 −12.038 1.00 89.90 C ATOM 2360 CG ASP A 318 −3.461 −12.198 −11.432 1.00 95.92 C ATOM 2361 OD1 ASP A 318 −3.452 −13.417 −11.683 1.00 95.22 O ATOM 2362 OD2 ASP A 318 −2.619 −11.645 −10.700 1.00 106.94 O ATOM 2363 C ASP A 318 −5.553 −11.750 −14.279 1.00 74.07 C ATOM 2364 O ASP A 318 −6.430 −11.033 −14.695 1.00 75.49 O ATOM 2365 N ASN A 319 −5.556 −13.066 −14.405 1.00 64.88 N ATOM 2366 CA ASN A 319 −6.571 −13.783 −15.131 1.00 57.55 C ATOM 2367 CB ASN A 319 −7.957 −13.257 −14.818 1.00 56.76 C ATOM 2368 C ASN A 319 −6.302 −13.664 −16.601 1.00 51.83 C ATOM 2369 O ASN A 319 −7.148 −13.977 −17.404 1.00 50.32 O ATOM 2370 N GLY A 320 −5.113 −13.207 −16.952 1.00 50.23 N ATOM 2371 CA GLY A 320 −4.745 −13.049 −18.339 1.00 54.38 C ATOM 2372 C GLY A 320 −5.195 −11.758 −18.966 1.00 55.95 C ATOM 2373 O GLY A 320 −5.089 −11.572 −20.158 1.00 53.42 O ATOM 2374 N VAL A 321 −5.701 −10.862 −18.141 1.00 59.97 N ATOM 2375 CA VAL A 321 −6.178 −9.587 −18.600 1.00 57.19 C ATOM 2376 CB VAL A 321 −7.449 −9.204 −17.884 1.00 59.80 C ATOM 2377 CG1 VAL A 321 −7.932 −7.875 −18.388 1.00 62.54 C ATOM 2378 CG2 VAL A 321 −8.497 −10.258 −18.114 1.00 60.11 C ATOM 2379 C VAL A 321 −5.152 −8.523 −18.355 1.00 54.75 C ATOM 2380 O VAL A 321 −4.493 −8.522 −17.341 1.00 50.12 O ATOM 2381 N VAL A 322 −5.021 −7.623 −19.316 1.00 53.86 N ATOM 2382 CA VAL A 322 −4.057 −6.544 −19.260 1.00 54.48 C ATOM 2383 CB VAL A 322 −3.022 −6.742 −20.345 1.00 56.87 C ATOM 2384 CG1 VAL A 322 −1.959 −5.685 −20.262 1.00 56.55 C ATOM 2385 CG2 VAL A 322 −2.399 −8.099 −20.201 1.00 56.84 C ATOM 2386 C VAL A 322 −4.669 −5.200 −19.522 1.00 50.20 C ATOM 2387 O VAL A 322 −5.553 −5.081 −20.320 1.00 47.59 O ATOM 2388 N PHE A 323 −4.168 −4.179 −18.856 1.00 48.94 N ATOM 2389 CA PHE A 323 −4.694 −2.857 −19.059 1.00 49.42 C ATOM 2390 CB PHE A 323 −4.823 −2.077 −17.769 1.00 49.26 C ATOM 2391 CG PHE A 323 −5.307 −0.684 −17.981 1.00 47.81 C ATOM 2392 CD1 PHE A 323 −6.604 −0.448 −18.311 1.00 46.07 C ATOM 2393 CE1 PHE A 323 −7.051 0.817 −18.529 1.00 44.63 C ATOM 2394 CZ PHE A 323 −6.195 1.865 −18.422 1.00 48.23 C ATOM 2395 CE2 PHE A 323 −4.892 1.646 −18.107 1.00 49.35 C ATOM 2396 CD2 PHE A 323 −4.456 0.377 −17.885 1.00 48.22 C ATOM 2397 C PHE A 323 −3.751 −2.128 −19.940 1.00 45.81 C ATOM 2398 O PHE A 323 −2.582 −2.091 −19.685 1.00 46.38 O ATOM 2399 N VAL A 324 −4.270 −1.536 −20.987 1.00 44.02 N ATOM 2400 CA VAL A 324 −3.409 −0.813 −21.905 1.00 44.39 C ATOM 2401 CB VAL A 324 −3.565 −1.274 −23.365 1.00 46.23 C ATOM 2402 CG1 VAL A 324 −2.622 −0.474 −24.241 1.00 47.91 C ATOM 2403 CG2 VAL A 324 −3.279 −2.753 −23.498 1.00 46.22 C ATOM 2404 C VAL A 324 −3.859 0.629 −21.811 1.00 45.99 C ATOM 2405 O VAL A 324 −4.939 0.992 −22.315 1.00 45.88 O ATOM 2406 N GLY A 325 −3.046 1.445 −21.136 1.00 44.59 N ATOM 2407 CA GLY A 325 −3.258 2.876 −21.120 1.00 40.45 C ATOM 2408 C GLY A 325 −2.619 3.531 −22.327 1.00 36.19 C ATOM 2409 O GLY A 325 −1.486 3.258 −22.653 1.00 34.25 O ATOM 2410 N SER A 326 −3.315 4.462 −22.918 1.00 35.05 N ATOM 2411 CA SER A 326 −2.861 5.081 −24.132 1.00 38.89 C ATOM 2412 CB SER A 326 −3.686 4.542 −25.331 1.00 37.41 C ATOM 2413 OG SER A 326 −3.308 5.187 −26.531 1.00 35.64 O ATOM 2414 C SER A 326 −2.986 6.595 −24.072 1.00 41.14 C ATOM 2415 O SER A 326 −3.908 7.154 −23.470 1.00 42.10 O ATOM 2416 N ARG A 327 −2.097 7.263 −24.774 1.00 45.62 N ATOM 2417 CA ARG A 327 −2.262 8.691 −24.966 1.00 50.73 C ATOM 2418 CB ARG A 327 −0.988 9.435 −24.592 1.00 56.63 C ATOM 2419 CG ARG A 327 −0.828 9.401 −23.087 1.00 61.93 C ATOM 2420 CD ARG A 327 0.438 10.031 −22.532 1.00 69.79 C ATOM 2421 NE ARG A 327 0.651 11.382 −23.042 1.00 73.98 N ATOM 2422 CZ ARG A 327 0.125 12.488 −22.567 1.00 65.53 C ATOM 2423 NH1 ARG A 327 −0.681 12.479 −21.525 1.00 75.01 N ATOM 2424 NH2 ARG A 327 0.422 13.602 −23.163 1.00 62.80 N ATOM 2425 C ARG A 327 −2.728 9.054 −26.338 1.00 48.37 C ATOM 2426 O ARG A 327 −3.407 10.071 −26.498 1.00 51.02 O ATOM 2427 N LEU A 328 −2.414 8.215 −27.311 1.00 46.54 N ATOM 2428 CA LEU A 328 −2.705 8.546 −28.692 1.00 46.88 C ATOM 2429 CB LEU A 328 −1.537 8.135 −29.579 1.00 49.19 C ATOM 2430 CG LEU A 328 −0.305 8.889 −29.145 1.00 50.84 C ATOM 2431 CD1 LEU A 328 0.888 8.495 −29.989 1.00 52.68 C ATOM 2432 CD2 LEU A 328 −0.599 10.353 −29.280 1.00 49.64 C ATOM 2433 C LEU A 328 −3.948 7.926 −29.241 1.00 43.17 C ATOM 2434 O LEU A 328 −4.333 8.289 −30.336 1.00 43.87 O ATOM 2435 N GLY A 329 −4.548 6.978 −28.537 1.00 37.92 N ATOM 2436 CA GLY A 329 −5.859 6.521 −28.915 1.00 37.82 C ATOM 2437 C GLY A 329 −6.530 6.031 −27.678 1.00 38.21 C ATOM 2438 O GLY A 329 −5.991 6.226 −26.601 1.00 35.93 O ATOM 2439 N ASP A 330 −7.650 5.322 −27.860 1.00 39.65 N ATOM 2440 CA ASP A 330 −8.427 4.731 −26.762 1.00 39.56 C ATOM 2441 CB ASP A 330 −9.653 3.979 −27.319 1.00 40.95 C ATOM 2442 CG ASP A 330 −10.754 4.895 −27.934 1.00 42.90 C ATOM 2443 OD1 ASP A 330 −10.731 6.157 −27.877 1.00 44.11 O ATOM 2444 OD2 ASP A 330 −11.707 4.308 −28.482 1.00 43.57 O ATOM 2445 C ASP A 330 −7.578 3.760 −25.884 1.00 39.92 C ATOM 2446 O ASP A 330 −6.645 3.174 −26.366 1.00 41.07 O ATOM 2447 N SER A 331 −7.901 3.633 −24.590 1.00 42.53 N ATOM 2448 CA SER A 331 −7.321 2.614 −23.704 1.00 41.76 C ATOM 2449 CB SER A 331 −7.275 3.073 −22.247 1.00 41.37 C ATOM 2450 OG SER A 331 −6.234 4.014 −22.073 1.00 42.35 O ATOM 2451 C SER A 331 −8.123 1.344 −23.825 1.00 41.05 C ATOM 2452 O SER A 331 −9.174 1.312 −24.478 1.00 40.76 O ATOM 2453 N GLN A 332 −7.584 0.285 −23.239 1.00 40.67 N ATOM 2454 CA GLN A 332 −8.116 −1.029 −23.439 1.00 42.30 C ATOM 2455 CB GLN A 332 −7.443 −1.708 −24.621 1.00 44.97 C ATOM 2456 CG GLN A 332 −7.258 −0.844 −25.869 1.00 47.35 C ATOM 2457 CD GLN A 332 −6.705 −1.675 −26.991 1.00 46.91 C ATOM 2458 OE1 GLN A 332 −5.488 −1.932 −27.079 1.00 47.21 O ATOM 2459 NE2 GLN A 332 −7.596 −2.150 −27.829 1.00 46.83 N ATOM 2460 C GLN A 332 −7.885 −1.922 −22.254 1.00 44.71 C ATOM 2461 O GLN A 332 −6.906 −1.757 −21.483 1.00 43.29 O ATOM 2462 N LEU A 333 −8.811 −2.881 −22.132 1.00 45.35 N ATOM 2463 CA LEU A 333 −8.564 −4.133 −21.472 1.00 43.13 C ATOM 2464 CB LEU A 333 −9.731 −4.479 −20.603 1.00 43.32 C ATOM 2465 CG LEU A 333 −9.783 −3.677 −19.319 1.00 46.24 C ATOM 2466 CD1 LEU A 333 −11.149 −3.867 −18.724 1.00 48.06 C ATOM 2467 CD2 LEU A 333 −8.745 −4.087 −18.290 1.00 48.30 C ATOM 2468 C LEU A 333 −8.405 −5.138 −22.605 1.00 43.82 C ATOM 2469 O LEU A 333 −9.195 −5.137 −23.535 1.00 42.93 O ATOM 2470 N VAL A 334 −7.355 −5.958 −22.553 1.00 45.88 N ATOM 2471 CA VAL A 334 −7.153 −7.061 −23.511 1.00 44.66 C ATOM 2472 CB VAL A 334 −5.945 −6.874 −24.427 1.00 43.39 C ATOM 2473 CG1 VAL A 334 −6.108 −5.642 −25.271 1.00 43.47 C ATOM 2474 CG2 VAL A 334 −4.661 −6.771 −23.632 1.00 45.15 C ATOM 2475 C VAL A 334 −6.927 −8.347 −22.778 1.00 46.32 C ATOM 2476 O VAL A 334 −6.336 −8.333 −21.694 1.00 41.50 O ATOM 2477 N LYS A 335 −7.375 −9.448 −23.400 1.00 54.52 N ATOM 2478 CA LYS A 335 −7.143 −10.821 −22.893 1.00 60.19 C ATOM 2479 CB LYS A 335 −8.383 −11.703 −23.087 1.00 66.02 C ATOM 2480 CG LYS A 335 −8.147 −13.168 −22.697 1.00 75.26 C ATOM 2481 CD LYS A 335 −9.372 −13.904 −22.165 1.00 79.06 C ATOM 2482 CE LYS A 335 −9.452 −13.776 −20.645 1.00 88.45 C ATOM 2483 NZ LYS A 335 −8.302 −14.408 −19.918 1.00 91.73 N ATOM 2484 C LYS A 335 −5.949 −11.424 −23.614 1.00 57.92 C ATOM 2485 O LYS A 335 −5.804 −11.186 −24.778 1.00 56.90 O ATOM 2486 N LEU A 336 −5.099 −12.170 −22.909 1.00 60.00 N ATOM 2487 CA LEU A 336 −4.011 −12.971 −23.503 1.00 62.72 C ATOM 2488 CB LEU A 336 −2.784 −12.825 −22.639 1.00 59.56 C ATOM 2489 CG LEU A 336 −2.426 −11.398 −22.326 1.00 59.99 C ATOM 2490 CD1 LEU A 336 −1.047 −11.377 −21.659 1.00 60.06 C ATOM 2491 CD2 LEU A 336 −2.443 −10.582 −23.613 1.00 62.03 C ATOM 2492 C LEU A 336 −4.303 −14.467 −23.584 1.00 69.81 C ATOM 2493 O LEU A 336 −5.131 −14.950 −22.831 1.00 70.16 O ATOM 2494 N ASN A 337 −3.579 −15.163 −24.433 1.00 83.01 N ATOM 2495 CA ASN A 337 −3.716 −16.588 −24.517 1.00 97.98 C ATOM 2496 CB ASN A 337 −4.491 −16.990 −25.750 1.00 107.74 C ATOM 2497 CG ASN A 337 −5.884 −16.427 −25.725 1.00 110.23 C ATOM 2498 OD1 ASN A 337 −6.095 −15.350 −25.193 1.00 99.20 O ATOM 2499 ND2 ASN A 337 −6.844 −17.161 −26.257 1.00 110.43 N ATOM 2500 C ASN A 337 −2.346 −17.208 −24.424 1.00 98.16 C ATOM 2501 O ASN A 337 −1.378 −16.678 −24.932 1.00 87.30 O ATOM 2502 N VAL A 338 −2.276 −18.341 −23.756 1.00 105.96 N ATOM 2503 CA VAL A 338 −1.024 −19.034 −23.566 1.00 110.26 C ATOM 2504 CB VAL A 338 −1.200 −20.281 −22.694 1.00 97.73 C ATOM 2505 C VAL A 338 −0.690 −19.527 −24.922 1.00 112.71 C ATOM 2506 O VAL A 338 −1.542 −19.507 −25.800 1.00 110.35 O ATOM 2507 N ASP A 339 0.527 −20.011 −25.118 1.00 122.42 N ATOM 2508 CA ASP A 339 0.889 −20.490 −26.436 1.00 119.30 C ATOM 2509 CB ASP A 339 2.378 −20.787 −26.517 1.00 108.45 C ATOM 2510 C ASP A 339 0.117 −21.770 −26.465 1.00 119.97 C ATOM 2511 O ASP A 339 0.642 −22.859 −26.348 1.00 108.75 O ATOM 2512 N SER A 340 −1.182 −21.578 −26.653 1.00 124.92 N ATOM 2513 CA SER A 340 −2.160 −22.633 −26.656 1.00 120.03 C ATOM 2514 CB SER A 340 −3.528 −22.074 −27.018 1.00 114.30 C ATOM 2515 C SER A 340 −1.701 −23.564 −27.718 1.00 114.51 C ATOM 2516 O SER A 340 −1.114 −23.138 −28.694 1.00 125.94 O ATOM 2517 N ASN A 341 −1.938 −24.842 −27.508 1.00 101.73 N ATOM 2518 CA ASN A 341 −1.463 −25.817 −28.439 1.00 91.03 C ATOM 2519 CB ASN A 341 −1.894 −27.196 −27.970 1.00 76.81 C ATOM 2520 C ASN A 341 −2.030 −25.536 −29.802 1.00 91.69 C ATOM 2521 O ASN A 341 −1.332 −25.620 −30.792 1.00 91.73 O ATOM 2522 N GLU A 342 −3.300 −25.195 −29.851 1.00 88.73 N ATOM 2523 CA GLU A 342 −3.943 −24.898 −31.111 1.00 88.31 C ATOM 2524 CB GLU A 342 −5.452 −24.848 −30.942 1.00 80.68 C ATOM 2525 C GLU A 342 −3.460 −23.656 −31.842 1.00 92.84 C ATOM 2526 O GLU A 342 −3.370 −23.657 −33.049 1.00 98.79 O ATOM 2527 N GLN A 343 −3.179 −22.582 −31.128 1.00 96.58 N ATOM 2528 CA GLN A 343 −2.758 −21.351 −31.781 1.00 95.27 C ATOM 2529 CB GLN A 343 −3.961 −20.421 −31.960 1.00 100.28 C ATOM 2530 CG GLN A 343 −3.662 −19.130 −32.707 1.00 99.81 C ATOM 2531 CD GLN A 343 −4.898 −18.517 −33.327 1.00 93.55 C ATOM 2532 OE1 GLN A 343 −5.028 −18.476 −34.541 1.00 89.00 O ATOM 2533 NE2 GLN A 343 −5.812 −18.049 −32.498 1.00 89.23 N ATOM 2534 C GLN A 343 −1.648 −20.614 −31.070 1.00 91.11 C ATOM 2535 O GLN A 343 −1.390 −20.815 −29.894 1.00 88.99 O ATOM 2536 N GLY A 344 −0.990 −19.741 −31.800 1.00 88.37 N ATOM 2537 CA GLY A 344 0.071 −18.968 −31.221 1.00 93.35 C ATOM 2538 C GLY A 344 −0.630 −18.085 −30.228 1.00 102.31 C ATOM 2539 O GLY A 344 −1.816 −17.838 −30.351 1.00 112.66 O ATOM 2540 N SER A 345 0.090 −17.623 −29.224 1.00 104.66 N ATOM 2541 CA SER A 345 −0.509 −16.778 −28.228 1.00 96.76 C ATOM 2542 CB SER A 345 0.573 −16.326 −27.297 1.00 94.76 C ATOM 2543 OG SER A 345 1.631 −15.832 −28.078 1.00 91.15 O ATOM 2544 C SER A 345 −1.019 −15.566 −28.941 1.00 92.69 C ATOM 2545 O SER A 345 −0.333 −15.011 −29.772 1.00 85.91 O ATOM 2546 N TYR A 346 −2.227 −15.152 −28.600 1.00 94.19 N ATOM 2547 CA TYR A 346 −2.849 −13.998 −29.215 1.00 87.02 C ATOM 2548 CB TYR A 346 −3.787 −14.395 −30.341 1.00 88.66 C ATOM 2549 CG TYR A 346 −4.878 −15.306 −29.915 1.00 96.93 C ATOM 2550 CD1 TYR A 346 −4.619 −16.373 −29.090 1.00 100.42 C ATOM 2551 CE1 TYR A 346 −5.621 −17.221 −28.693 1.00 104.15 C ATOM 2552 CZ TYR A 346 −6.896 −17.013 −29.136 1.00 108.30 C ATOM 2553 OH TYR A 346 −7.901 −17.861 −28.748 1.00 108.30 O ATOM 2554 CE2 TYR A 346 −7.176 −15.963 −29.970 1.00 106.91 C ATOM 2555 CD2 TYR A 346 −6.165 −15.118 −30.357 1.00 102.63 C ATOM 2556 C TYR A 346 −3.533 −13.140 −28.179 1.00 75.13 C ATOM 2557 O TYR A 346 −3.711 −13.541 −27.053 1.00 71.17 O ATOM 2558 N VAL A 347 −3.878 −11.941 −28.600 1.00 69.66 N ATOM 2559 CA VAL A 347 −4.451 −10.905 −27.791 1.00 68.07 C ATOM 2560 CB VAL A 347 −3.574 −9.650 −27.907 1.00 72.57 C ATOM 2561 CG1 VAL A 347 −4.227 −8.458 −27.217 1.00 76.82 C ATOM 2562 CG2 VAL A 347 −2.170 −9.915 −27.377 1.00 72.10 C ATOM 2563 C VAL A 347 −5.829 −10.552 −28.334 1.00 64.27 C ATOM 2564 O VAL A 347 −5.992 −10.384 −29.519 1.00 65.70 O ATOM 2565 N VAL A 348 −6.810 −10.411 −27.464 1.00 64.12 N ATOM 2566 CA VAL A 348 −8.149 −10.003 −27.865 1.00 65.78 C ATOM 2567 CB VAL A 348 −9.158 −11.123 −27.629 1.00 63.09 C ATOM 2568 CG1 VAL A 348 −10.500 −10.769 −28.261 1.00 64.52 C ATOM 2569 CG2 VAL A 348 −8.610 −12.392 −28.208 1.00 64.72 C ATOM 2570 C VAL A 348 −8.574 −8.774 −27.055 1.00 67.54 C ATOM 2571 O VAL A 348 −8.309 −8.719 −25.834 1.00 68.93 O ATOM 2572 N ALA A 349 −9.253 −7.822 −27.717 1.00 61.05 N ATOM 2573 CA ALA A 349 −9.685 −6.625 −27.037 1.00 59.92 C ATOM 2574 CB ALA A 349 −9.777 −5.442 −27.963 1.00 60.69 C ATOM 2575 C ALA A 349 −11.013 −6.963 −26.417 1.00 62.37 C ATOM 2576 O ALA A 349 −11.974 −7.329 −27.111 1.00 58.75 O ATOM 2577 N MET A 350 −10.992 −6.913 −25.083 1.00 65.74 N ATOM 2578 CA MET A 350 −12.144 −7.111 −24.238 1.00 64.53 C ATOM 2579 CB MET A 350 −11.728 −7.473 −22.839 1.00 66.75 C ATOM 2580 CG MET A 350 −11.084 −8.814 −22.673 1.00 71.70 C ATOM 2581 SD MET A 350 −10.666 −8.963 −20.927 1.00 80.65 S ATOM 2582 CE MET A 350 −12.215 −8.606 −20.043 1.00 77.57 C ATOM 2583 C MET A 350 −12.955 −5.853 −24.089 1.00 60.99 C ATOM 2584 O MET A 350 −14.147 −5.911 −24.144 1.00 65.38 O ATOM 2585 N GLU A 351 −12.337 −4.721 −23.822 1.00 59.79 N ATOM 2586 CA GLU A 351 −13.116 −3.518 −23.599 1.00 59.85 C ATOM 2587 CB GLU A 351 −13.456 −3.423 −22.119 1.00 63.56 C ATOM 2588 CG GLU A 351 −14.909 −3.114 −21.833 1.00 70.04 C ATOM 2589 CD GLU A 351 −15.061 −2.220 −20.616 1.00 77.63 C ATOM 2590 OE1 GLU A 351 −14.570 −2.625 −19.531 1.00 76.13 O ATOM 2591 OE2 GLU A 351 −15.645 −1.105 −20.762 1.00 85.40 O ATOM 2592 C GLU A 351 −12.367 −2.280 −24.084 1.00 56.70 C ATOM 2593 O GLU A 351 −11.139 −2.268 −24.134 1.00 52.87 O ATOM 2594 N THR A 352 −13.117 −1.246 −24.440 1.00 54.88 N ATOM 2595 CA THR A 352 −12.531 0.038 −24.866 1.00 52.99 C ATOM 2596 CB THR A 352 −12.903 0.307 −26.318 1.00 52.40 C ATOM 2597 OG1 THR A 352 −12.049 −0.468 −27.131 1.00 49.67 O ATOM 2598 CG2 THR A 352 −12.718 1.740 −26.689 1.00 54.51 C ATOM 2599 C THR A 352 −12.976 1.240 −24.048 1.00 49.29 C ATOM 2600 O THR A 352 −14.145 1.457 −23.845 1.00 51.07 O ATOM 2601 N PHE A 353 −12.042 2.075 −23.645 1.00 46.56 N ATOM 2602 CA PHE A 353 −12.431 3.334 −23.040 1.00 43.42 C ATOM 2603 CB PHE A 353 −11.839 3.417 −21.678 1.00 42.07 C ATOM 2604 CG PHE A 353 −11.771 2.132 −20.937 1.00 40.28 C ATOM 2605 CD1 PHE A 353 −12.803 1.720 −20.193 1.00 38.83 C ATOM 2606 CE1 PHE A 353 −12.713 0.598 −19.430 1.00 40.05 C ATOM 2607 CZ PHE A 353 −11.567 −0.137 −19.402 1.00 42.05 C ATOM 2608 CE2 PHE A 353 −10.485 0.273 −20.135 1.00 42.61 C ATOM 2609 CD2 PHE A 353 −10.595 1.415 −20.896 1.00 43.10 C ATOM 2610 C PHE A 353 −12.018 4.584 −23.898 1.00 42.49 C ATOM 2611 O PHE A 353 −10.876 4.676 −24.395 1.00 39.84 O ATOM 2612 N THR A 354 −12.943 5.537 −24.040 1.00 37.58 N ATOM 2613 CA THR A 354 −12.724 6.655 −24.899 1.00 36.21 C ATOM 2614 CB THR A 354 −13.961 7.527 −24.890 1.00 37.56 C ATOM 2615 OG1 THR A 354 −15.053 6.785 −25.421 1.00 39.89 O ATOM 2616 CG2 THR A 354 −13.793 8.778 −25.729 1.00 38.21 C ATOM 2617 C THR A 354 −11.544 7.535 −24.506 1.00 36.71 C ATOM 2618 O THR A 354 −11.316 7.869 −23.358 1.00 37.28 O ATOM 2619 N ASN A 355 −10.779 7.928 −25.502 1.00 39.06 N ATOM 2620 CA ASN A 355 −9.777 8.951 −25.347 1.00 38.25 C ATOM 2621 CB ASN A 355 −8.399 8.311 −25.403 1.00 37.90 C ATOM 2622 CG ASN A 355 −7.308 9.294 −25.111 1.00 40.81 C ATOM 2623 OD1 ASN A 355 −7.534 10.258 −24.386 1.00 42.09 O ATOM 2624 ND2 ASN A 355 −6.133 9.109 −25.712 1.00 43.34 N ATOM 2625 C ASN A 355 −9.972 9.955 −26.489 1.00 39.59 C ATOM 2626 O ASN A 355 −9.784 9.611 −27.646 1.00 46.17 O ATOM 2627 N LEU A 356 −10.369 11.172 −26.194 1.00 37.81 N ATOM 2628 CA LEU A 356 −10.488 12.165 −27.221 1.00 38.50 C ATOM 2629 CB LEU A 356 −11.313 13.318 −26.750 1.00 42.71 C ATOM 2630 CG LEU A 356 −12.603 12.976 −26.084 1.00 44.96 C ATOM 2631 CD1 LEU A 356 −13.367 14.254 −25.952 1.00 46.46 C ATOM 2632 CD2 LEU A 356 −13.330 12.036 −26.987 1.00 45.61 C ATOM 2633 C LEU A 356 −9.173 12.701 −27.712 1.00 38.60 C ATOM 2634 O LEU A 356 −8.997 12.975 −28.871 1.00 38.13 O ATOM 2635 N GLY A 357 −8.258 12.887 −26.789 1.00 40.54 N ATOM 2636 CA GLY A 357 −6.978 13.473 −27.085 1.00 43.83 C ATOM 2637 C GLY A 357 −6.052 12.622 −27.874 1.00 45.92 C ATOM 2638 O GLY A 357 −6.200 11.448 −27.799 1.00 65.67 O ATOM 2639 N PRO A 358 −5.049 13.178 −28.663 1.00 44.09 N ATOM 2640 CA PRO A 358 −4.935 14.635 −28.674 1.00 42.14 C ATOM 2641 CB PRO A 358 −3.648 14.876 −29.425 1.00 42.08 C ATOM 2642 CG PRO A 358 −2.898 13.626 −29.369 1.00 42.41 C ATOM 2643 CD PRO A 358 −3.963 12.665 −29.599 1.00 44.11 C ATOM 2644 C PRO A 358 −5.985 15.314 −29.470 1.00 43.75 C ATOM 2645 O PRO A 358 −6.323 14.793 −30.481 1.00 48.07 O ATOM 2646 N ILE A 359 −6.462 16.471 −29.055 1.00 43.15 N ATOM 2647 CA ILE A 359 −7.426 17.179 −29.842 1.00 39.85 C ATOM 2648 CB ILE A 359 −8.379 17.965 −28.999 1.00 39.23 C ATOM 2649 CG1 ILE A 359 −9.223 17.002 −28.191 1.00 39.55 C ATOM 2650 CD1 ILE A 359 −10.444 17.631 −27.596 1.00 40.77 C ATOM 2651 CG2 ILE A 359 −9.236 18.827 −29.885 1.00 39.14 C ATOM 2652 C ILE A 359 −6.443 18.040 −30.529 1.00 38.12 C ATOM 2653 O ILE A 359 −5.661 18.711 −29.915 1.00 39.28 O ATOM 2654 N VAL A 360 −6.469 17.985 −31.832 1.00 38.33 N ATOM 2655 CA VAL A 360 −5.453 18.596 −32.657 1.00 37.10 C ATOM 2656 CB VAL A 360 −4.804 17.446 −33.488 1.00 36.52 C ATOM 2657 CG1 VAL A 360 −4.541 17.821 −34.931 1.00 38.72 C ATOM 2658 CG2 VAL A 360 −3.545 16.922 −32.805 1.00 34.28 C ATOM 2659 C VAL A 360 −6.105 19.688 −33.469 1.00 36.00 C ATOM 2660 O VAL A 360 −5.442 20.513 −33.991 1.00 37.24 O ATOM 2661 N ASP A 361 −7.404 19.606 −33.656 1.00 36.48 N ATOM 2662 CA ASP A 361 −8.169 20.673 −34.189 1.00 39.51 C ATOM 2663 CB ASP A 361 −7.989 20.767 −35.695 1.00 43.84 C ATOM 2664 CG ASP A 361 −8.640 22.012 −36.289 1.00 50.76 C ATOM 2665 OD1 ASP A 361 −9.077 22.926 −35.517 1.00 50.70 O ATOM 2666 OD2 ASP A 361 −8.680 22.090 −37.552 1.00 57.16 O ATOM 2667 C ASP A 361 −9.592 20.275 −33.854 1.00 39.87 C ATOM 2668 O ASP A 361 −9.814 19.101 −33.472 1.00 37.54 O ATOM 2669 N MET A 362 −10.531 21.228 −33.950 1.00 39.37 N ATOM 2670 CA MET A 362 −11.932 20.925 −33.763 1.00 43.33 C ATOM 2671 CB MET A 362 −12.298 20.810 −32.272 1.00 50.53 C ATOM 2672 CG MET A 362 −12.326 22.090 −31.405 1.00 51.75 C ATOM 2673 SD MET A 362 −12.043 21.718 −29.649 1.00 52.40 S ATOM 2674 CE MET A 362 −12.592 23.233 −28.901 1.00 56.09 C ATOM 2675 C MET A 362 −12.771 21.963 −34.404 1.00 43.96 C ATOM 2676 O MET A 362 −12.250 22.924 −34.846 1.00 54.03 O ATOM 2677 N CYS A 363 −14.075 21.763 −34.479 1.00 44.09 N ATOM 2678 CA CYS A 363 −14.972 22.803 −34.931 1.00 44.37 C ATOM 2679 CB CYS A 363 −15.001 22.793 −36.431 1.00 46.09 C ATOM 2680 SG CYS A 363 −16.005 21.456 −37.078 1.00 49.90 S ATOM 2681 C CYS A 363 −16.358 22.544 −34.362 1.00 44.67 C ATOM 2682 O CYS A 363 −16.659 21.438 −33.912 1.00 39.70 O ATOM 2683 N VAL A 364 −17.193 23.579 −34.344 1.00 49.16 N ATOM 2684 CA VAL A 364 −18.525 23.473 −33.698 1.00 51.56 C ATOM 2685 CB VAL A 364 −18.850 24.615 −32.679 1.00 50.09 C ATOM 2686 CG1 VAL A 364 −20.161 24.308 −31.931 1.00 49.21 C ATOM 2687 CG2 VAL A 364 −17.724 24.812 −31.660 1.00 48.48 C ATOM 2688 C VAL A 364 −19.560 23.544 −34.761 1.00 52.31 C ATOM 2689 O VAL A 364 −19.527 24.467 −35.558 1.00 59.25 O ATOM 2690 N VAL A 365 −20.485 22.616 −34.762 1.00 51.40 N ATOM 2691 CA VAL A 365 −21.434 22.552 −35.827 1.00 57.18 C ATOM 2692 CB VAL A 365 −21.207 21.312 −36.729 1.00 59.23 C ATOM 2693 CG1 VAL A 365 −22.373 21.101 −37.703 1.00 59.50 C ATOM 2694 CG2 VAL A 365 −19.884 21.411 −37.483 1.00 58.17 C ATOM 2695 C VAL A 365 −22.715 22.338 −35.147 1.00 66.17 C ATOM 2696 O VAL A 365 −22.826 21.412 −34.332 1.00 74.90 O ATOM 2697 N ASP A 366 −23.697 23.148 −35.503 1.00 73.27 N ATOM 2698 CA ASP A 366 −25.088 22.842 −35.189 1.00 77.82 C ATOM 2699 CB ASP A 366 −25.834 24.157 −35.334 1.00 82.27 C ATOM 2700 CG ASP A 366 −27.244 24.090 −34.854 1.00 88.15 C ATOM 2701 OD1 ASP A 366 −27.733 22.961 −34.504 1.00 87.29 O ATOM 2702 OD2 ASP A 366 −27.860 25.197 −34.834 1.00 87.59 O ATOM 2703 C ASP A 366 −25.665 21.678 −36.116 1.00 84.13 C ATOM 2704 O ASP A 366 −26.476 21.910 −37.023 1.00 83.10 O ATOM 2705 N LEU A 367 −25.247 20.445 −35.873 1.00 91.96 N ATOM 2706 CA LEU A 367 −25.676 19.340 −36.723 1.00 84.19 C ATOM 2707 CB LEU A 367 −24.960 18.066 −36.306 1.00 76.55 C ATOM 2708 CG LEU A 367 −23.507 17.935 −36.696 1.00 69.60 C ATOM 2709 CD1 LEU A 367 −23.005 16.609 −36.201 1.00 69.36 C ATOM 2710 CD2 LEU A 367 −23.366 18.011 −38.191 1.00 63.88 C ATOM 2711 C LEU A 367 −27.140 18.997 −36.805 1.00 85.99 C ATOM 2712 O LEU A 367 −27.651 18.827 −37.892 1.00 90.77 O ATOM 2713 N GLU A 368 −27.830 18.908 −35.684 1.00 83.96 N ATOM 2714 CA GLU A 368 −29.240 18.553 −35.723 1.00 83.07 C ATOM 2715 CB GLU A 368 −29.711 18.018 −34.386 1.00 80.27 C ATOM 2716 CG GLU A 368 −28.859 16.872 −33.888 1.00 85.93 C ATOM 2717 CD GLU A 368 −29.055 15.604 −34.680 1.00 88.52 C ATOM 2718 OE1 GLU A 368 −30.176 15.376 −35.144 1.00 97.45 O ATOM 2719 OE2 GLU A 368 −28.098 14.828 −34.833 1.00 81.36 O ATOM 2720 C GLU A 368 −30.085 19.704 −36.201 1.00 86.80 C ATOM 2721 O GLU A 368 −31.254 19.551 −36.468 1.00 91.87 O ATOM 2722 N ARG A 369 −29.479 20.872 −36.285 1.00 94.00 N ATOM 2723 CA ARG A 369 −30.185 22.057 −36.722 1.00 94.30 C ATOM 2724 CB ARG A 369 −30.969 21.761 −37.991 1.00 83.04 C ATOM 2725 C ARG A 369 −31.122 22.496 −35.620 1.00 96.90 C ATOM 2726 O ARG A 369 −32.026 23.278 −35.843 1.00 100.95 O ATOM 2727 N GLN A 370 −30.896 21.988 −34.423 1.00 92.97 N ATOM 2728 CA GLN A 370 −31.753 22.302 −33.310 1.00 95.37 C ATOM 2729 CB GLN A 370 −31.798 21.107 −32.357 1.00 96.51 C ATOM 2730 CG GLN A 370 −31.752 19.772 −33.080 1.00 102.45 C ATOM 2731 CD GLN A 370 −32.229 18.593 −32.251 1.00 103.60 C ATOM 2732 OE1 GLN A 370 −31.646 18.261 −31.229 1.00 100.79 O ATOM 2733 NE2 GLN A 370 −33.280 17.935 −32.715 1.00 101.75 N ATOM 2734 C GLN A 370 −31.338 23.546 −32.563 1.00 95.23 C ATOM 2735 O GLN A 370 −32.000 23.935 −31.622 1.00 97.85 O ATOM 2736 N GLY A 371 −30.245 24.175 −32.961 1.00 97.69 N ATOM 2737 CA GLY A 371 −29.760 25.377 −32.203 1.00 92.85 C ATOM 2738 C GLY A 371 −28.922 24.985 −30.979 1.00 87.75 C ATOM 2739 O GLY A 371 −29.048 25.563 −29.900 1.00 89.04 O ATOM 2740 N GLN A 372 −28.076 23.977 −31.184 1.00 83.99 N ATOM 2741 CA GLN A 372 −27.375 23.200 −30.162 1.00 79.69 C ATOM 2742 CB GLN A 372 −28.246 21.979 −29.703 1.00 87.01 C ATOM 2743 CG GLN A 372 −27.566 20.681 −29.205 1.00 92.32 C ATOM 2744 CD GLN A 372 −26.702 20.819 −27.925 1.00 98.80 C ATOM 2745 OE1 GLN A 372 −25.537 20.356 −27.876 1.00 90.53 O ATOM 2746 NE2 GLN A 372 −27.277 21.429 −26.875 1.00 103.41 N ATOM 2747 C GLN A 372 −26.127 22.778 −30.905 1.00 69.98 C ATOM 2748 O GLN A 372 −26.200 21.960 −31.815 1.00 78.42 O ATOM 2749 N GLY A 373 −25.003 23.394 −30.592 1.00 62.55 N ATOM 2750 CA GLY A 373 −23.713 22.994 −31.165 1.00 60.02 C ATOM 2751 C GLY A 373 −23.132 21.649 −30.714 1.00 55.40 C ATOM 2752 O GLY A 373 −23.336 21.189 −29.594 1.00 59.37 O ATOM 2753 N GLN A 374 −22.427 21.006 −31.624 1.00 52.61 N ATOM 2754 CA GLN A 374 −21.787 19.734 −31.394 1.00 50.82 C ATOM 2755 CB GLN A 374 −22.472 18.612 −32.210 1.00 52.84 C ATOM 2756 CG GLN A 374 −23.878 18.275 −31.707 1.00 58.19 C ATOM 2757 CD GLN A 374 −24.497 16.917 −32.166 1.00 67.74 C ATOM 2758 OE1 GLN A 374 −24.533 16.578 −33.359 1.00 73.65 O ATOM 2759 NE2 GLN A 374 −25.069 16.173 −31.205 1.00 73.18 N ATOM 2760 C GLN A 374 −20.334 19.992 −31.767 1.00 46.42 C ATOM 2761 O GLN A 374 −20.031 20.778 −32.655 1.00 46.18 O ATOM 2762 N LEU A 375 −19.423 19.398 −31.046 1.00 44.17 N ATOM 2763 CA LEU A 375 −18.035 19.671 −31.282 1.00 47.95 C ATOM 2764 CB LEU A 375 −17.253 19.741 −29.955 1.00 52.03 C ATOM 2765 CG LEU A 375 −15.974 20.591 −29.863 1.00 54.67 C ATOM 2766 CD1 LEU A 375 −16.396 22.031 −30.083 1.00 56.56 C ATOM 2767 CD2 LEU A 375 −15.220 20.423 −28.540 1.00 53.50 C ATOM 2768 C LEU A 375 −17.621 18.481 −32.093 1.00 46.56 C ATOM 2769 O LEU A 375 −18.135 17.400 −31.859 1.00 52.53 O ATOM 2770 N VAL A 376 −16.741 18.673 −33.060 1.00 42.64 N ATOM 2771 CA VAL A 376 −16.221 17.576 −33.830 1.00 43.47 C ATOM 2772 CB VAL A 376 −16.713 17.607 −35.302 1.00 44.77 C ATOM 2773 CG1 VAL A 376 −16.144 16.392 −36.057 1.00 46.62 C ATOM 2774 CG2 VAL A 376 −18.244 17.593 −35.391 1.00 42.74 C ATOM 2775 C VAL A 376 −14.722 17.725 −33.793 1.00 42.47 C ATOM 2776 O VAL A 376 −14.240 18.757 −34.174 1.00 44.90 O ATOM 2777 N THR A 377 −13.980 16.721 −33.367 1.00 39.90 N ATOM 2778 CA THR A 377 −12.557 16.917 −33.094 1.00 41.02 C ATOM 2779 CB THR A 377 −12.186 16.449 −31.646 1.00 40.30 C ATOM 2780 OG1 THR A 377 −12.416 15.034 −31.472 1.00 38.91 O ATOM 2781 CG2 THR A 377 −12.956 17.210 −30.644 1.00 39.17 C ATOM 2782 C THR A 377 −11.710 16.091 −34.012 1.00 42.15 C ATOM 2783 O THR A 377 −12.054 14.955 −34.251 1.00 48.51 O ATOM 2784 N CYS A 378 −10.596 16.608 −34.502 1.00 40.26 N ATOM 2785 CA CYS A 378 −9.571 15.711 −34.986 1.00 41.41 C ATOM 2786 CB CYS A 378 −8.586 16.463 −35.869 1.00 42.92 C ATOM 2787 SG CYS A 378 −9.370 17.123 −37.319 1.00 44.09 S ATOM 2788 C CYS A 378 −8.821 15.111 −33.782 1.00 41.84 C ATOM 2789 O CYS A 378 −7.999 15.797 −33.158 1.00 45.37 O ATOM 2790 N SER A 379 −9.057 13.839 −33.472 1.00 39.84 N ATOM 2791 CA SER A 379 −8.377 13.175 −32.335 1.00 38.82 C ATOM 2792 CB SER A 379 −9.409 12.654 −31.382 1.00 37.14 C ATOM 2793 OG SER A 379 −10.123 13.748 −30.917 1.00 38.65 O ATOM 2794 C SER A 379 −7.409 12.033 −32.683 1.00 38.08 C ATOM 2795 O SER A 379 −7.628 11.277 −33.616 1.00 43.04 O ATOM 2796 N GLY A 380 −6.381 11.886 −31.887 1.00 34.85 N ATOM 2797 CA GLY A 380 −5.469 10.795 −32.039 1.00 34.66 C ATOM 2798 C GLY A 380 −4.435 10.888 −33.092 1.00 37.46 C ATOM 2799 O GLY A 380 −4.279 11.894 −33.725 1.00 43.00 O ATOM 2800 N ALA A 381 −3.712 9.803 −33.266 1.00 39.92 N ATOM 2801 CA ALA A 381 −2.701 9.764 −34.259 1.00 42.37 C ATOM 2802 CB ALA A 381 −1.508 10.455 −33.687 1.00 42.11 C ATOM 2803 C ALA A 381 −2.312 8.363 −34.670 1.00 43.33 C ATOM 2804 O ALA A 381 −2.487 7.445 −33.923 1.00 45.50 O ATOM 2805 N PHE A 382 −1.774 8.205 −35.863 1.00 42.32 N ATOM 2806 CA PHE A 382 −1.206 6.956 −36.328 1.00 43.08 C ATOM 2807 CB PHE A 382 0.067 6.729 −35.506 1.00 48.59 C ATOM 2808 CG PHE A 382 0.995 7.871 −35.463 1.00 54.08 C ATOM 2809 CD1 PHE A 382 1.100 8.724 −36.502 1.00 54.29 C ATOM 2810 CE1 PHE A 382 1.984 9.767 −36.451 1.00 57.50 C ATOM 2811 CZ PHE A 382 2.789 9.941 −35.357 1.00 58.66 C ATOM 2812 CE2 PHE A 382 2.704 9.067 −34.319 1.00 61.85 C ATOM 2813 CD2 PHE A 382 1.817 8.034 −34.385 1.00 59.79 C ATOM 2814 C PHE A 382 −1.963 5.615 −36.360 1.00 38.66 C ATOM 2815 O PHE A 382 −1.354 4.577 −36.175 1.00 35.23 O ATOM 2816 N LYS A 383 −3.236 5.616 −36.665 1.00 36.14 N ATOM 2817 CA LYS A 383 −4.119 4.433 −36.729 1.00 39.41 C ATOM 2818 CB LYS A 383 −3.486 3.060 −36.625 1.00 43.86 C ATOM 2819 CG LYS A 383 −3.027 2.672 −35.257 1.00 45.25 C ATOM 2820 CD LYS A 383 −1.932 1.647 −35.339 1.00 47.22 C ATOM 2821 CE LYS A 383 −1.810 0.891 −34.041 1.00 49.93 C ATOM 2822 NZ LYS A 383 −3.125 0.383 −33.603 1.00 51.99 N ATOM 2823 C LYS A 383 −5.047 4.644 −35.639 1.00 40.67 C ATOM 2824 O LYS A 383 −6.201 4.276 −35.724 1.00 41.56 O ATOM 2825 N GLU A 384 −4.588 5.318 −34.615 1.00 40.09 N ATOM 2826 CA GLU A 384 −5.623 5.711 −33.700 1.00 39.03 C ATOM 2827 CB GLU A 384 −5.002 5.953 −32.350 1.00 40.35 C ATOM 2828 CG GLU A 384 −4.008 4.889 −31.920 1.00 41.82 C ATOM 2829 CD GLU A 384 −4.689 3.602 −31.657 1.00 45.20 C ATOM 2830 OE1 GLU A 384 −5.959 3.662 −31.518 1.00 47.96 O ATOM 2831 OE2 GLU A 384 −3.954 2.563 −31.589 1.00 48.52 O ATOM 2832 C GLU A 384 −6.380 6.959 −34.134 1.00 37.87 C ATOM 2833 O GLU A 384 −7.317 7.373 −33.457 1.00 39.98 O ATOM 2834 N GLY A 385 −6.017 7.554 −35.241 1.00 35.98 N ATOM 2835 CA GLY A 385 −6.668 8.776 −35.626 1.00 36.91 C ATOM 2836 C GLY A 385 −8.138 8.584 −35.694 1.00 34.99 C ATOM 2837 O GLY A 385 −8.593 7.532 −36.008 1.00 38.57 O ATOM 2838 N SER A 386 −8.880 9.602 −35.332 1.00 33.17 N ATOM 2839 CA SER A 386 −10.303 9.514 −35.354 1.00 35.44 C ATOM 2840 CB SER A 386 −10.781 8.776 −34.141 1.00 36.69 C ATOM 2841 OG SER A 386 −10.045 9.148 −33.008 1.00 35.35 O ATOM 2842 C SER A 386 −10.917 10.855 −35.348 1.00 36.08 C ATOM 2843 O SER A 386 −10.255 11.830 −35.172 1.00 37.71 O ATOM 2844 N LEU A 387 −12.209 10.888 −35.551 1.00 37.39 N ATOM 2845 CA LEU A 387 −12.957 12.100 −35.504 1.00 38.75 C ATOM 2846 CB LEU A 387 −13.801 12.287 −36.737 1.00 41.50 C ATOM 2847 CG LEU A 387 −13.206 12.727 −38.058 1.00 44.78 C ATOM 2848 CD1 LEU A 387 −14.325 13.008 −39.021 1.00 44.26 C ATOM 2849 CD2 LEU A 387 −12.373 13.960 −37.893 1.00 46.34 C ATOM 2850 C LEU A 387 −13.867 11.738 −34.389 1.00 38.98 C ATOM 2851 O LEU A 387 −14.208 10.610 −34.260 1.00 40.01 O ATOM 2852 N ARG A 388 −14.246 12.680 −33.562 1.00 36.56 N ATOM 2853 CA ARG A 388 −15.123 12.427 −32.443 1.00 37.90 C ATOM 2854 CB ARG A 388 −14.374 12.589 −31.114 1.00 39.13 C ATOM 2855 CG ARG A 388 −13.186 11.669 −30.864 1.00 39.37 C ATOM 2856 CD ARG A 388 −13.550 10.163 −30.718 1.00 38.61 C ATOM 2857 NE ARG A 388 −12.323 9.363 −30.889 1.00 37.91 N ATOM 2858 CZ ARG A 388 −11.861 8.396 −30.072 1.00 37.09 C ATOM 2859 NH1 ARG A 388 −12.464 7.957 −28.969 1.00 36.21 N ATOM 2860 NH2 ARG A 388 −10.720 7.864 −30.381 1.00 36.63 N ATOM 2861 C ARG A 388 −16.233 13.451 −32.448 1.00 39.42 C ATOM 2862 O ARG A 388 −15.956 14.631 −32.560 1.00 43.94 O ATOM 2863 N ILE A 389 −17.478 13.031 −32.284 1.00 40.27 N ATOM 2864 CA ILE A 389 −18.599 −13.936 −32.285 1.00 40.58 C ATOM 2865 CB ILE A 389 −19.704 13.437 −33.203 1.00 41.95 C ATOM 2866 CG1 ILE A 389 −19.245 13.493 −34.660 1.00 43.20 C ATOM 2867 CD1 ILE A 389 −18.736 −12.167 −35.165 1.00 44.12 C ATOM 2868 CG2 ILE A 389 −20.956 14.289 −33.063 1.00 44.46 C ATOM 2869 C ILE A 389 −19.124 14.021 −30.877 1.00 43.79 C ATOM 2870 O ILE A 389 −19.715 13.053 −30.367 1.00 47.61 O ATOM 2871 N ILE A 390 −18.954 15.190 −30.259 1.00 43.79 N ATOM 2872 CA ILE A 390 −19.303 15.380 −28.873 1.00 43.78 C ATOM 2873 CB ILE A 390 −18.135 16.032 −28.153 1.00 47.43 C ATOM 2874 CG1 ILE A 390 −16.956 15.024 −28.049 1.00 49.50 C ATOM 2875 CD1 ILE A 390 −15.579 15.565 −28.391 1.00 49.34 C ATOM 2876 CG2 ILE A 390 −18.572 16.479 −26.770 1.00 48.94 C ATOM 2877 C ILE A 390 −20.566 16.216 −28.784 1.00 44.29 C ATOM 2878 O ILE A 390 −20.551 17.383 −29.138 1.00 44.68 O ATOM 2879 N ARG A 391 −21.670 15.565 −28.395 1.00 46.27 N ATOM 2880 CA ARG A 391 −22.967 16.182 −28.070 1.00 43.98 C ATOM 2881 CB ARG A 391 −24.188 15.360 −28.601 1.00 37.55 C ATOM 2882 C ARG A 391 −22.823 16.125 −26.548 1.00 46.17 C ATOM 2883 O ARG A 391 −23.646 15.565 −25.810 1.00 50.00 O ATOM 2884 N ASN A 392 −23.935 17.912 −26.054 1.00 50.03 N ATOM 2885 CA ASN A 392 −24.393 17.904 −24.672 1.00 51.00 C ATOM 2886 CB ASN A 392 −24.425 19.336 −24.191 1.00 58.54 C ATOM 2887 CG ASN A 392 −24.510 19.452 −22.714 1.00 67.59 C ATOM 2888 OD1 ASN A 392 −25.217 18.687 −22.069 1.00 79.77 O ATOM 2889 ND2 ASN A 392 −23.786 20.420 −22.152 1.00 74.32 N ATOM 2890 C ASN A 392 −25.796 17.332 −24.633 1.00 47.21 C ATOM 2891 O ASN A 392 −26.570 17.605 −25.491 1.00 48.52 O ATOM 2892 N GLY A 393 −26.158 16.564 −23.635 1.00 47.29 N ATOM 2893 CA GLY A 393 −27.602 16.281 −23.397 1.00 47.62 C ATOM 2894 C GLY A 393 −27.925 15.073 −22.515 1.00 45.38 C ATOM 2895 O GLY A 393 −27.045 14.276 −22.200 1.00 48.06 O ATOM 2896 N ILE A 394 −29.182 14.914 −22.152 1.00 41.71 N ATOM 2897 CA ILE A 394 −29.613 13.644 −21.593 1.00 43.78 C ATOM 2898 CB ILE A 394 −31.007 13.714 −20.972 1.00 43.93 C ATOM 2899 CG1 ILE A 394 −31.051 14.724 −19.851 1.00 48.45 C ATOM 2900 CD1 ILE A 394 −32.463 15.165 −19.545 1.00 50.76 C ATOM 2901 CG2 ILE A 394 −31.376 12.389 −20.365 1.00 41.32 C ATOM 2902 C ILE A 394 −29.715 12.558 −22.660 1.00 44.97 C ATOM 2903 O ILE A 394 −30.467 12.698 −23.629 1.00 43.54 O ATOM 2904 N GLY A 395 −29.054 11.429 −22.415 1.00 47.88 N ATOM 2905 CA GLY A 395 −29.134 10.280 −23.326 1.00 47.81 C ATOM 2906 C GLY A 395 −30.145 9.213 −22.959 1.00 46.75 C ATOM 2907 O GLY A 395 −30.520 9.091 −21.816 1.00 43.97 O ATOM 2908 N ILE A 396 −30.532 8.406 −23.948 1.00 49.98 N ATOM 2909 CA ILE A 396 −31.544 7.342 −23.797 1.00 49.88 C ATOM 2910 CB ILE A 396 −32.700 7.517 −24.827 1.00 48.95 C ATOM 2911 CG1 ILE A 396 −33.411 8.839 −24.622 1.00 50.86 C ATOM 2912 CD1 ILE A 396 −34.040 9.041 −23.257 1.00 54.66 C ATOM 2913 CG2 ILE A 396 −33.705 6.378 −24.764 1.00 48.76 C ATOM 2914 C ILE A 396 −30.917 5.992 −24.049 1.00 47.36 C ATOM 2915 O ILE A 396 −30.493 5.743 −25.157 1.00 44.29 O ATOM 2916 N HIS A 397 −30.924 5.109 −23.055 1.00 49.01 N ATOM 2917 CA HIS A 397 −30.428 3.753 −23.260 1.00 54.12 C ATOM 2918 CB HIS A 397 −29.963 3.122 −21.952 1.00 57.44 C ATOM 2919 CG HIS A 397 −28.755 3.799 −21.353 1.00 65.47 C ATOM 2920 ND1 HIS A 397 −27.525 3.828 −21.979 1.00 72.37 N ATOM 2921 CE1 HIS A 397 −26.663 4.510 −21.239 1.00 70.49 C ATOM 2922 NE2 HIS A 397 −27.290 4.928 −20.157 1.00 69.67 N ATOM 2923 CD2 HIS A 397 −28.595 4.487 −20.196 1.00 68.48 C ATOM 2924 C HIS A 397 −31.507 2.923 −23.961 1.00 57.11 C ATOM 2925 O HIS A 397 −32.533 2.610 −23.371 1.00 58.21 O ATOM 2926 N GLU A 398 −31.295 2.585 −25.234 1.00 56.90 N ATOM 2927 CA GLU A 398 −32.367 1.978 −26.002 1.00 56.45 C ATOM 2928 CB GLU A 398 −32.230 2.332 −27.474 1.00 61.02 C ATOM 2929 CG GLU A 398 −32.508 3.794 −27.735 1.00 68.07 C ATOM 2930 CD GLU A 398 −32.634 4.122 −29.205 1.00 76.74 C ATOM 2931 OE1 GLU A 398 −32.413 5.346 −29.536 1.00 76.24 O ATOM 2932 OE2 GLU A 398 −32.963 3.158 −29.987 1.00 76.88 O ATOM 2933 C GLU A 398 −32.365 0.494 −25.856 1.00 51.56 C ATOM 2934 O GLU A 398 −31.414 −0.090 −26.237 1.00 47.59 O ATOM 2935 N HIS A 399 −33.446 −0.124 −25.387 1.00 52.81 N ATOM 2936 CA HIS A 399 −33.499 −1.592 −25.283 1.00 54.95 C ATOM 2937 CB HIS A 399 −33.947 −2.002 −23.888 1.00 57.72 C ATOM 2938 CG HIS A 399 −33.268 −1.225 −22.815 1.00 58.73 C ATOM 2939 ND1 HIS A 399 −33.941 −0.701 −21.736 1.00 59.46 N ATOM 2940 CE1 HIS A 399 −33.098 −0.047 −20.963 1.00 57.52 C ATOM 2941 NE2 HIS A 399 −31.911 −0.081 −21.535 1.00 60.76 N ATOM 2942 CD2 HIS A 399 −31.987 −0.819 −22.692 1.00 58.34 C ATOM 2943 C HIS A 399 −34.304 −2.331 −26.347 1.00 54.76 C ATOM 2944 O HIS A 399 −33.963 −3.474 −26.660 1.00 60.69 O ATOM 2945 N ALA A 400 −35.365 −1.730 −26.887 1.00 53.81 N ATOM 2946 CA ALA A 400 −36.048 −2.318 −28.069 1.00 54.26 C ATOM 2947 CB ALA A 400 −37.240 −3.117 −27.651 1.00 54.80 C ATOM 2948 C ALA A 400 −36.484 −1.325 −29.123 1.00 54.67 C ATOM 2949 O ALA A 400 −36.728 −0.168 −28.835 1.00 57.62 O ATOM 2950 N SER A 401 −36.605 −1.784 −30.356 1.00 54.95 N ATOM 2951 CA SER A 401 −37.100 −0.919 −31.406 1.00 54.51 C ATOM 2952 CB SER A 401 −35.952 −0.341 −32.226 1.00 56.43 C ATOM 2953 OG SER A 401 −36.324 0.941 −32.715 1.00 60.38 O ATOM 2954 C SER A 401 −38.108 −1.646 −32.278 1.00 52.98 C ATOM 2955 O SER A 401 −38.049 −2.895 −32.453 1.00 54.21 O ATOM 2956 N ILE A 402 −39.058 −0.852 −32.776 1.00 48.73 N ATOM 2957 CA ILE A 402 −40.129 −1.351 −33.588 1.00 49.41 C ATOM 2958 CB ILE A 402 −41.356 −1.705 −32.726 1.00 51.90 C ATOM 2959 CG1 ILE A 402 −41.020 −2.797 −31.668 1.00 53.28 C ATOM 2960 CD1 ILE A 402 −42.220 −3.293 −30.865 1.00 51.94 C ATOM 2961 CG2 ILE A 402 −42.511 −2.181 −33.592 1.00 49.50 C ATOM 2962 C ILE A 402 −40.521 −0.304 −34.596 1.00 51.01 C ATOM 2963 O ILE A 402 −40.945 0.772 −34.226 1.00 48.47 O ATOM 2964 N ASP A 403 −40.343 −0.638 −35.872 1.00 59.00 N ATOM 2965 CA ASP A 403 −40.975 0.017 −37.037 1.00 63.12 C ATOM 2966 CB ASP A 403 −40.353 −0.584 −38.327 1.00 65.78 C ATOM 2967 CG ASP A 403 −40.928 0.015 −39.634 1.00 75.46 C ATOM 2968 OD1 ASP A 403 −41.555 1.129 −39.648 1.00 86.91 O ATOM 2969 OD2 ASP A 403 −40.730 −0.647 −40.680 1.00 73.92 O ATOM 2970 C ASP A 403 −42.563 −0.099 −37.042 1.00 62.39 C ATOM 2971 O ASP A 403 −43.134 −1.204 −37.195 1.00 57.59 O ATOM 2972 N LEU A 404 −43.228 1.063 −36.867 1.00 60.49 N ATOM 2973 CA LEU A 404 −44.704 1.235 −36.911 1.00 59.08 C ATOM 2974 CB LEU A 404 −45.401 0.939 −35.592 1.00 61.80 C ATOM 2975 CG LEU A 404 −45.945 −0.452 −35.371 1.00 65.21 C ATOM 2976 CD1 LEU A 404 −46.220 −0.643 −33.882 1.00 65.43 C ATOM 2977 CD2 LEU A 404 −47.211 −0.619 −36.204 1.00 69.04 C ATOM 2978 C LEU A 404 −44.943 2.676 −37.184 1.00 56.00 C ATOM 2979 O LEU A 404 −44.858 3.518 −36.287 1.00 58.91 O ATOM 2980 N PRO A 405 −45.233 3.001 −38.422 1.00 55.64 N ATOM 2981 CA PRO A 405 −45.348 4.427 −38.707 1.00 55.37 C ATOM 2982 CB PRO A 405 −44.958 4.491 −40.156 1.00 53.93 C ATOM 2983 CG PRO A 405 −45.491 3.204 −40.684 1.00 55.95 C ATOM 2984 CD PRO A 405 −45.438 2.182 −39.611 1.00 54.26 C ATOM 2985 C PRO A 405 −46.758 4.984 −38.440 1.00 53.37 C ATOM 2986 O PRO A 405 −47.748 4.247 −38.432 1.00 51.76 O ATOM 2987 N GLY A 406 −46.803 6.273 −38.144 1.00 54.51 N ATOM 2988 CA GLY A 406 −48.045 7.017 −37.939 1.00 54.16 C ATOM 2989 C GLY A 406 −48.607 6.945 −36.548 1.00 56.11 C ATOM 2990 O GLY A 406 −49.821 7.047 −36.364 1.00 61.52 O ATOM 2991 N ILE A 407 −47.748 6.758 −35.557 1.00 57.14 N ATOM 2992 CA ILE A 407 −48.245 6.637 −34.223 1.00 57.90 C ATOM 2993 CB ILE A 407 −47.203 6.075 −33.274 1.00 57.56 C ATOM 2994 CG1 ILE A 407 −46.950 4.612 −33.640 1.00 58.06 C ATOM 2995 CD1 ILE A 407 −45.865 3.898 −32.850 1.00 57.98 C ATOM 2996 CG2 ILE A 407 −47.712 6.214 −31.843 1.00 56.64 C ATOM 2997 C ILE A 407 −48.678 8.023 −33.782 1.00 62.41 C ATOM 2998 O ILE A 407 −47.962 9.003 −34.005 1.00 62.50 O ATOM 2999 N LYS A 408 −49.868 8.087 −33.183 1.00 64.52 N ATOM 3000 CA LYS A 408 −50.447 9.329 −32.665 1.00 62.29 C ATOM 3001 CB LYS A 408 51.792 9.561 −33.324 1.00 64.00 C ATOM 3002 CG LYS A 408 −51.741 9.524 −34.842 1.00 64.34 C ATOM 3003 CD LYS A 408 −51.003 10.716 −35.437 1.00 64.86 C ATOM 3004 CE LYS A 408 −51.025 10.653 −36.959 1.00 70.24 C ATOM 3005 NZ LYS A 408 −50.250 11.751 −37.600 1.00 73.24 N ATOM 3006 C LYS A 408 −50.622 9.353 −31.157 1.00 58.81 C ATOM 3007 O LYS A 408 −50.826 10.422 −30.592 1.00 62.49 O ATOM 3008 N GLY A 409 −50.577 8.193 −30.512 1.00 54.61 N ATOM 3009 CA GLY A 409 −50.559 8.128 −29.067 1.00 54.73 C ATOM 3010 C GLY A 409 −50.099 6.794 −28.488 1.00 55.71 C ATOM 3011 O GLY A 409 −50.249 5.727 −29.078 1.00 60.14 O ATOM 3012 N LEU A 410 −49.534 6.888 −27.309 1.00 54.48 N ATOM 3013 CA LEU A 410 −49.054 5.786 −26.536 1.00 54.46 C ATOM 3014 CB LEU A 410 −47.587 6.021 −26.249 1.00 56.20 C ATOM 3015 CG LEU A 410 −46.480 5.413 −27.070 1.00 58.23 C ATOM 3016 CD1 LEU A 410 −46.964 4.886 −28.407 1.00 59.71 C ATOM 3017 CD2 LEU A 410 −45.355 6.444 −27.195 1.00 59.08 C ATOM 3018 C LEU A 410 −49.737 5.837 −25.182 1.00 55.15 C ATOM 3019 O LEU A 410 −49.839 6.913 −24.557 1.00 60.75 O ATOM 3020 N TRP A 411 −50.171 4.687 −24.702 1.00 51.76 N ATOM 3021 CA TRP A 411 −50.605 4.567 −23.334 1.00 51.24 C ATOM 3022 CB TRP A 411 −52.117 4.725 −23.215 1.00 54.17 C ATOM 3023 CG TRP A 411 −52.542 5.978 −23.728 1.00 53.71 C ATOM 3024 CD1 TRP A 411 −52.665 7.131 −23.048 1.00 53.95 C ATOM 3025 NE1 TRP A 411 −53.026 8.132 −23.902 1.00 55.25 N ATOM 3026 CE2 TRP A 411 −53.095 7.629 −25.172 1.00 54.25 C ATOM 3027 CD2 TRP A 411 −52.797 6.266 −25.090 1.00 55.50 C ATOM 3028 CE3 TRP A 411 −52.807 5.492 −26.258 1.00 58.15 C ATOM 3029 CZ3 TRP A 411 −53.123 6.103 −27.447 1.00 57.42 C ATOM 3030 CH2 TRP A 411 −53.427 7.475 −27.486 1.00 55.97 C ATOM 3031 CZ2 TRP A 411 −53.420 8.245 −26.361 1.00 53.25 C ATOM 3032 C TRP A 411 −50.229 3.221 −22.813 1.00 51.17 C ATOM 3033 O TRP A 411 −50.533 2.194 −23.436 1.00 53.53 O ATOM 3034 N PRO A 412 −49.593 3.197 −21.655 1.00 49.64 N ATOM 3035 CA PRO A 412 −49.339 1.952 −21.004 1.00 50.84 C ATOM 3036 CB PRO A 412 −48.274 2.313 −20.008 1.00 52.76 C ATOM 3037 CG PRO A 412 −48.605 3.691 −19.606 1.00 51.82 C ATOM 3038 CD PRO A 412 −49.230 4.327 −20.810 1.00 50.73 C ATOM 3039 C PRO A 412 −50.533 1.606 −20.249 1.00 51.37 C ATOM 3040 O PRO A 412 −51.335 2.487 −19.977 1.00 50.50 O ATOM 3041 N LEU A 413 −50.605 0.362 −19.815 1.00 56.43 N ATOM 3042 CA LEU A 413 −51.824 −0.156 −19.179 1.00 59.26 C ATOM 3043 CB LEU A 413 −52.879 −0.221 −20.270 1.00 60.79 C ATOM 3044 CG LEU A 413 −54.138 −1.033 −20.326 1.00 63.74 C ATOM 3045 CD1 LEU A 413 −54.963 −0.564 −21.530 1.00 64.44 C ATOM 3046 CD2 LEU A 413 −53.836 −2.510 −20.466 1.00 67.55 C ATOM 3047 C LEU A 413 −51.519 −1.501 −18.557 1.00 59.24 C ATOM 3048 O LEU A 413 −50.609 −2.215 −19.030 1.00 63.45 O ATOM 3049 N ARG A 414 −52.265 −1.845 −17.509 1.00 58.43 N ATOM 3050 CA ARG A 414 −52.100 −3.128 −16.785 1.00 61.92 C ATOM 3051 CB ARG A 414 −51.969 −2.897 −15.287 1.00 66.03 C ATOM 3052 CG ARG A 414 −50.544 −2.511 −14.860 1.00 70.73 C ATOM 3053 CD ARG A 414 −50.409 −1.767 −13.527 1.00 72.03 C ATOM 3054 NE ARG A 414 −51.643 −1.835 −12.730 1.00 75.99 N ATOM 3055 CZ ARG A 414 −52.429 −0.798 −12.388 1.00 74.73 C ATOM 3056 NH1 ARG A 414 −52.140 0.468 −12.700 1.00 70.45 N ATOM 3057 NH2 ARG A 414 −53.533 −1.037 −11.687 1.00 76.39 N ATOM 3058 C ARG A 414 −53.289 −4.021 −17.094 1.00 61.51 C ATOM 3059 O ARG A 414 −54.365 −3.787 −16.574 1.00 61.49 O ATOM 3060 N SER A 415 −53.089 −4.998 −17.989 1.00 64.64 N ATOM 3061 CA SER A 415 −54.135 −5.919 −18.468 1.00 64.89 C ATOM 3062 CB SER A 415 −53.651 −6.669 −19.705 1.00 59.61 C ATOM 3063 C SER A 415 −54.587 −6.941 −17.414 1.00 67.07 C ATOM 3064 O SER A 415 −55.678 −7.491 −17.513 1.00 66.06 O ATOM 3065 N ASP A 416 −53.746 −7.195 −16.420 1.00 69.59 N ATOM 3066 CA ASP A 416 −54.052 −8.154 −15.386 1.00 75.14 C ATOM 3067 CB ASP A 416 −53.117 −9.353 −15.485 1.00 77.22 C ATOM 3068 CG ASP A 416 −53.136 −10.173 −14.254 1.00 79.90 C ATOM 3069 OD1 ASP A 416 −54.225 −10.307 −13.677 1.00 87.24 O ATOM 3070 OD2 ASP A 416 −52.073 −10.632 −13.820 1.00 83.34 O ATOM 3071 C ASP A 416 −53.945 −7.471 −14.016 1.00 77.41 C ATOM 3072 O ASP A 416 −52.854 −7.132 −13.562 1.00 72.50 O ATOM 3073 N PRO A 417 −55.084 −7.308 −13.338 1.00 84.17 N ATOM 3074 CA PRO A 417 −55.163 −6.426 −12.165 1.00 88.93 C ATOM 3075 CB PRO A 417 −56.671 −6.315 −11.917 1.00 92.21 C ATOM 3076 CG PRO A 417 −57.230 −7.581 −12.472 1.00 90.68 C ATOM 3077 CD PRO A 417 −56.392 −7.905 −13.666 1.00 87.03 C ATOM 3078 C PRO A 417 −54.472 −6.883 −10.886 1.00 88.51 C ATOM 3079 O PRO A 417 −54.210 −6.057 −10.018 1.00 80.00 O ATOM 3080 N ASN A 418 −54.220 −8.177 −10.740 1.00 97.93 N ATOM 3081 CA ASN A 418 −53.475 −8.660 −9.570 1.00 101.90 C ATOM 3082 CB ASN A 418 −54.186 −9.880 −8.925 1.00 98.09 C ATOM 3083 CG ASN A 418 −54.234 −11.086 −9.843 1.00 101.67 C ATOM 3084 OD1 ASN A 418 −54.163 −10.957 −11.063 1.00 104.47 O ATOM 3085 ND2 ASN A 418 −54.345 −12.267 −9.261 1.00 101.58 N ATOM 3086 C ASN A 418 −51.949 −8.880 −9.857 1.00 96.48 C ATOM 3087 O ASN A 418 −51.270 −9.500 −9.043 1.00 100.21 O ATOM 3088 N ARG A 419 −51.427 −8.378 −10.994 1.00 88.55 N ATOM 3089 CA ARG A 419 −49.959 −8.139 −11.193 1.00 83.58 C ATOM 3090 CB ARG A 419 −49.393 −8.801 −12.470 1.00 79.54 C ATOM 3091 C ARG A 419 −49.723 −6.629 −11.227 1.00 79.54 C ATOM 3092 O ARG A 419 −50.572 −5.874 −11.689 1.00 79.56 O ATOM 3093 N GLU A 420 −48.561 −6.193 −10.765 1.00 79.83 N ATOM 3094 CA GLU A 420 −48.366 −4.803 −10.319 1.00 84.06 C ATOM 3095 CB GLU A 420 −47.612 −4.827 −8.968 1.00 95.40 C ATOM 3096 CG GLU A 420 −47.923 −3.667 −8.012 1.00 100.52 C ATOM 3097 CD GLU A 420 −48.540 −4.144 −6.693 1.00 103.91 C ATOM 3098 OE1 GLU A 420 −49.600 −3.609 −6.285 1.00 97.17 O ATOM 3099 OE2 GLU A 420 −47.982 −5.082 −6.082 1.00 107.73 O ATOM 3100 C GLU A 420 −47.594 −3.955 −11.322 1.00 79.30 C ATOM 3101 O GLU A 420 −46.897 −3.018 −10.933 1.00 80.81 O ATOM 3102 N THR A 421 −47.758 −4.250 −12.610 1.00 72.23 N ATOM 3103 CA THR A 421 −46.745 −3.941 −13.624 1.00 61.47 C ATOM 3104 CB THR A 421 −45.643 −5.033 −13.559 1.00 55.59 C ATOM 3105 OG1 THR A 421 −44.427 −4.482 −14.052 1.00 52.25 O ATOM 3106 CG2 THR A 421 −46.034 −6.361 −14.304 1.00 52.11 C ATOM 3107 C THR A 421 −47.338 −3.894 −15.031 1.00 58.84 C ATOM 3108 O THR A 421 −48.055 −4.798 −15.417 1.00 60.74 O ATOM 3109 N ASP A 422 −47.036 −2.872 −15.821 1.00 58.55 N ATOM 3110 CA ASP A 422 −47.611 −2.783 −17.183 1.00 59.10 C ATOM 3111 CB ASP A 422 −47.119 −1.564 −17.934 1.00 62.40 C ATOM 3112 CG ASP A 422 −47.451 −0.267 −17.232 1.00 66.95 C ATOM 3113 OD1 ASP A 422 −48.657 0.039 −17.026 1.00 68.66 O ATOM 3114 OD2 ASP A 422 −46.478 0.459 −16.910 1.00 71.52 O ATOM 3115 C ASP A 422 −47.302 −4.005 −18.040 1.00 56.80 C ATOM 3116 O ASP A 422 −46.220 −4.627 −17.919 1.00 55.84 O ATOM 3117 N ASP A 423 −48.283 −4.379 −18.851 1.00 50.55 N ATOM 3118 CA ASP A 423 −48.097 −5.456 −19.785 1.00 49.77 C ATOM 3119 CB ASP A 423 −48.615 −6.728 −19.149 1.00 50.68 C ATOM 3120 CG ASP A 423 −50.122 −6.775 −19.019 1.00 52.52 C ATOM 3121 OD1 ASP A 423 −50.858 −5.835 −19.377 1.00 55.69 O ATOM 3122 OD2 ASP A 423 −50.593 −7.816 −18.564 1.00 57.40 O ATOM 3123 C ASP A 423 −48.719 −5.170 −21.161 1.00 52.23 C ATOM 3124 O ASP A 423 −48.830 −6.045 −22.042 1.00 49.80 O ATOM 3125 N THR A 424 −49.095 −3.920 −21.371 1.00 51.45 N ATOM 3126 CA THR A 424 −49.706 −3.558 −22.593 1.00 49.36 C ATOM 3127 CB THR A 424 −51.188 −3.564 −22.380 1.00 50.19 C ATOM 3128 OG1 THR A 424 −51.551 −4.887 −22.020 1.00 51.86 O ATOM 3129 CG2 THR A 424 −51.945 −3.156 −23.647 1.00 51.71 C ATOM 3130 C THR A 424 −49.226 −2.190 −22.956 1.00 49.48 C ATOM 3131 O THR A 424 −48.903 −1.384 −22.126 1.00 52.86 O ATOM 3132 N LEU A 425 −49.157 −1.948 −24.230 1.00 50.63 N ATOM 3133 CA LEU A 425 −48.932 −0.639 −24.739 1.00 50.72 C ATOM 3134 CB LEU A 425 −47.589 −0.644 −25.430 1.00 49.30 C ATOM 3135 CG LEU A 425 −46.807 0.632 −25.486 1.00 48.41 C ATOM 3136 CD1 LEU A 425 −46.842 1.350 −24.163 1.00 50.83 C ATOM 3137 CD2 LEU A 425 −45.386 0.244 −25.803 1.00 49.49 C ATOM 3138 C LEU A 425 −50.034 −0.510 −25.739 1.00 52.01 C ATOM 3139 O LEU A 425 −50.310 −1.488 −26.441 1.00 53.28 O ATOM 3140 N VAL A 426 −50.689 0.645 −25.796 1.00 50.36 N ATOM 3141 CA VAL A 426 −51.773 0.834 −26.753 1.00 49.39 C ATOM 3142 CB VAL A 426 −53.113 1.103 −26.045 1.00 50.69 C ATOM 3143 CG1 VAL A 426 −54.254 1.256 −27.057 1.00 50.77 C ATOM 3144 CG2 VAL A 426 −53.423 −0.059 −25.096 1.00 50.38 C ATOM 3145 C VAL A 426 −51.369 1.937 −27.665 1.00 46.35 C ATOM 3146 O VAL A 426 −50.809 2.910 −27.203 1.00 47.52 O ATOM 3147 N LEU A 427 −51.593 1.766 −28.958 1.00 45.54 N ATOM 3148 CA LEU A 427 −51.101 2.740 −29.925 1.00 51.43 C ATOM 3149 CB LEU A 427 −50.051 2.138 −30.842 1.00 53.54 C ATOM 3150 CG LEU A 427 −48.674 1.957 −30.216 1.00 55.42 C ATOM 3151 CD1 LEU A 427 −48.624 0.856 −29.159 1.00 54.95 C ATOM 3152 CD2 LEU A 427 −47.672 1.657 −31.301 1.00 58.12 C ATOM 3153 C LEU A 427 −52.234 3.217 −30.771 1.00 54.11 C ATOM 3154 O LEU A 427 −52.953 2.378 −31.339 1.00 53.49 O ATOM 3155 N SER A 428 −52.397 4.541 −30.877 1.00 54.07 N ATOM 3156 CA SER A 428 −53.450 5.071 −31.718 1.00 55.42 C ATOM 3157 CB SER A 428 −54.253 6.202 −31.034 1.00 60.05 C ATOM 3158 OG SER A 428 −53.702 7.500 −31.229 1.00 65.05 O ATOM 3159 C SER A 428 −52.818 5.496 −33.013 1.00 51.60 C ATOM 3160 O SER A 428 −51.662 5.875 −33.050 1.00 49.29 O ATOM 3161 N PHE A 429 −53.598 5.382 −34.080 1.00 53.24 N ATOM 3162 CA PHE A 429 −53.224 5.805 −35.437 1.00 53.52 C ATOM 3163 CB PHE A 429 −52.922 4.581 −36.285 1.00 51.14 C ATOM 3164 CG PHE A 429 −51.762 3.767 −35.800 1.00 48.87 C ATOM 3165 CD1 PHE A 429 −51.937 2.807 −34.828 1.00 48.67 C ATOM 3166 CE1 PHE A 429 −50.879 2.051 −34.365 1.00 46.00 C ATOM 3167 CZ PHE A 429 −49.640 2.235 −34.913 1.00 47.11 C ATOM 3168 CE2 PHE A 429 −49.444 3.195 −35.891 1.00 46.94 C ATOM 3169 CD2 PHE A 429 −50.499 3.948 −36.329 1.00 48.09 C ATOM 3170 C PHE A 429 −54.415 6.522 −36.066 1.00 54.62 C ATOM 3171 O PHE A 429 −55.520 6.465 −35.536 1.00 55.87 O ATOM 3172 N VAL A 430 −54.215 7.160 −37.209 1.00 55.59 N ATOM 3173 CA VAL A 430 −55.311 7.876 −37.847 1.00 57.39 C ATOM 3174 CB VAL A 430 −54.881 8.673 −39.112 1.00 63.19 C ATOM 3175 CG1 VAL A 430 −55.076 7.877 −40.422 1.00 69.73 C ATOM 3176 CG2 VAL A 430 −55.634 9.990 −39.185 1.00 64.68 C ATOM 3177 C VAL A 430 −56.436 6.879 −38.100 1.00 55.45 C ATOM 3178 O VAL A 430 −56.260 5.873 −38.754 1.00 53.13 O ATOM 3179 N GLY A 431 −57.566 7.173 −37.483 1.00 58.77 N ATOM 3180 CA GLY A 431 −58.730 6.308 −37.408 1.00 62.11 C ATOM 3181 C GLY A 431 −58.548 4.842 −37.102 1.00 59.37 C ATOM 3182 O GLY A 431 −59.141 4.018 −37.753 1.00 64.87 O ATOM 3183 N GLN A 432 −57.761 4.498 −36.112 1.00 57.86 N ATOM 3184 CA GLN A 432 −57.397 3.114 −35.970 1.00 61.05 C ATOM 3185 CB GLN A 432 −56.507 2.762 −37.163 1.00 68.60 C ATOM 3186 CG GLN A 432 −56.158 1.299 −37.380 1.00 79.20 C ATOM 3187 CD GLN A 432 −55.000 1.174 −38.373 1.00 85.61 C ATOM 3188 OE1 GLN A 432 −55.090 1.683 −39.484 1.00 88.20 O ATOM 3189 NE2 GLN A 432 −53.893 0.543 −37.958 1.00 87.94 N ATOM 3190 C GLN A 432 −56.668 2.956 −34.648 1.00 57.64 C ATOM 3191 O GLN A 432 −55.816 3.770 −34.335 1.00 56.53 O ATOM 3192 N THR A 433 −57.013 1.939 −33.862 1.00 55.68 N ATOM 3193 CA THR A 433 −56.337 1.673 −32.560 1.00 56.93 C ATOM 3194 CB THR A 433 −57.293 1.873 −31.372 1.00 53.95 C ATOM 3195 OG1 THR A 433 −57.594 3.260 −31.272 1.00 54.80 O ATOM 3196 CG2 THR A 433 −56.654 1.428 −30.072 1.00 52.33 C ATOM 3197 C THR A 433 −55.719 0.256 −32.536 1.00 56.09 C ATOM 3198 O THR A 433 −56.276 −0.651 −33.118 1.00 59.19 O ATOM 3199 N ARG A 434 −54.563 0.103 −31.891 1.00 53.78 N ATOM 3200 CA ARG A 434 −53.822 −1.151 −31.847 1.00 53.96 C ATOM 3201 CB ARG A 434 −52.623 −1.058 −32.727 1.00 54.86 C ATOM 3202 CG ARG A 434 −52.863 −0.900 −34.201 1.00 58.73 C ATOM 3203 CD ARG A 434 −51.602 −1.438 −34.884 1.00 61.56 C ATOM 3204 NE ARG A 434 −51.377 −1.000 −36.244 1.00 61.49 N ATOM 3205 CZ ARG A 434 −50.590 −1.631 −37.099 1.00 64.68 C ATOM 3206 NH1 ARG A 434 −49.931 −2.750 −36.786 1.00 63.62 N ATOM 3207 NH2 ARG A 434 −50.482 −1.134 −38.306 1.00 71.75 N ATOM 3208 C ARG A 434 −53.241 −1.464 −30.477 1.00 54.45 C ATOM 3209 O ARG A 434 −52.829 −0.553 −29.748 1.00 57.88 O ATOM 3210 N VAL A 435 −53.104 −2.745 −30.167 1.00 50.92 N ATOM 3211 CA VAL A 435 −52.731 −3.124 −28.837 1.00 50.43 C ATOM 3212 CB VAL A 435 −53.933 −3.690 −28.086 1.00 50.42 C ATOM 3213 CG1 VAL A 435 −53.532 −4.081 −26.680 1.00 51.26 C ATOM 3214 CG2 VAL A 435 −55.037 −2.638 −28.020 1.00 51.18 C ATOM 3215 C VAL A 435 −51.574 −4.105 −28.869 1.00 51.99 C ATOM 3216 O VAL A 435 −51.690 −5.166 −29.428 1.00 53.13 O ATOM 3217 N LEU A 436 −50.459 −3.723 −28.249 1.00 51.77 N ATOM 3218 CA LEU A 436 −49.290 −4.561 −28.111 1.00 50.41 C ATOM 3219 CB LEU A 436 −48.022 −3.731 −28.349 1.00 47.79 C ATOM 3220 CG LEU A 436 −48.033 −2.914 −29.634 1.00 45.89 C ATOM 3221 CD1 LEU A 436 −46.719 −2.207 −29.855 1.00 44.19 C ATOM 3222 CD2 LEU A 436 −48.334 −3.835 −30.778 1.00 47.79 C ATOM 3223 C LEU A 436 −49.260 −5.120 −26.703 1.00 54.01 C ATOM 3224 O LEU A 436 −49.204 −4.333 −25.746 1.00 53.76 O ATOM 3225 N MET A 437 −49.284 −6.457 −26.572 1.00 55.11 N ATOM 3226 CA MET A 437 −49.029 −7.089 −25.281 1.00 57.48 C ATOM 3227 CB MET A 437 −49.804 −8.387 −25.138 1.00 61.73 C ATOM 3228 CG MET A 437 −49.172 −9.548 −25.866 1.00 66.78 C ATOM 3229 SD MET A 437 −50.179 −11.022 −25.799 1.00 73.96 S ATOM 3230 CE MET A 437 −50.105 −11.399 −24.029 1.00 74.10 C ATOM 3231 C MET A 437 −47.540 −7.345 −25.119 1.00 54.51 C ATOM 3232 O MET A 437 −46.853 −7.533 −26.109 1.00 53.19 O ATOM 3233 N LEU A 438 −47.075 −7.380 −23.864 1.00 55.01 N ATOM 3234 CA LEU A 438 −45.669 −7.577 −23.510 1.00 55.60 C ATOM 3235 CB LEU A 438 −45.106 −6.300 −22.912 1.00 55.65 C ATOM 3236 CG LEU A 438 −45.087 −5.133 −23.875 1.00 54.32 C ATOM 3237 CD1 LEU A 438 −46.406 −4.409 −23.859 1.00 58.02 C ATOM 3238 CD2 LEU A 438 −44.013 −4.155 −23.494 1.00 53.07 C ATOM 3239 C LEU A 438 −45.433 −8.698 −22.493 1.00 57.76 C ATOM 3240 O LEU A 438 −45.989 −8.703 −21.388 1.00 56.04 O ATOM 3241 N ASN A 439 −44.580 −9.639 −22.877 1.00 60.90 N ATOM 3242 CA ASN A 439 −44.086 −10.678 −21.964 1.00 65.31 C ATOM 3243 CB ASN A 439 −44.667 −12.060 −22.304 1.00 69.08 C ATOM 3244 CG ASN A 439 −46.167 −11.999 −22.539 1.00 77.42 C ATOM 3245 OD1 ASN A 439 −46.969 −12.419 −21.696 1.00 90.07 O ATOM 3246 ND2 ASN A 439 −46.557 −11.419 −23.668 1.00 79.65 N ATOM 3247 C ASN A 439 −42.572 −10.665 −22.045 1.00 60.15 C ATOM 3248 O ASN A 439 −42.012 −10.994 −23.079 1.00 57.04 O ATOM 3249 N GLY A 440 −41.926 −10.229 −20.968 1.00 56.67 N ATOM 3250 CA GLY A 440 −40.514 −10.004 −20.962 1.00 56.00 C ATOM 3251 C GLY A 440 −40.264 −9.007 −22.054 1.00 60.06 C ATOM 3252 O GLY A 440 −40.839 −7.884 −22.043 1.00 70.02 O ATOM 3253 N GLU A 441 −39.463 −9.443 −23.021 1.00 57.33 N ATOM 3254 CA GLU A 441 −39.027 −8.602 −24.102 1.00 59.09 C ATOM 3255 CB GLU A 441 −37.521 −8.740 −24.246 1.00 61.05 C ATOM 3256 CG GLU A 441 −36.721 −8.124 −23.119 1.00 60.60 C ATOM 3257 CD GLU A 441 −35.211 −8.222 −23.317 1.00 60.70 C ATOM 3258 OE1 GLU A 441 −34.501 −7.940 −22.360 1.00 69.39 O ATOM 3259 OE2 GLU A 441 −34.691 −8.582 −24.378 1.00 57.88 O ATOM 3260 C GLU A 441 −39.706 −8.923 −25.436 1.00 60.39 C ATOM 3261 O GLU A 441 −39.340 −8.306 −26.482 1.00 64.59 O ATOM 3262 N GLU A 442 −40.689 −9.845 −25.394 1.00 58.79 N ATOM 3263 CA GLU A 442 −41.506 −10.261 −26.569 1.00 57.16 C ATOM 3264 CB GLU A 442 −41.900 −11.740 −26.478 1.00 58.80 C ATOM 3265 CG GLU A 442 −40.735 −12.727 −26.445 1.00 62.87 C ATOM 3266 CD GLU A 442 −41.200 −14.130 −26.124 1.00 66.35 C ATOM 3267 OE1 GLU A 442 −42.106 −14.625 −26.814 1.00 71.52 O ATOM 3268 OE2 GLU A 442 −40.689 −14.731 −25.155 1.00 73.37 O ATOM 3269 C GLU A 442 −42.784 −9.434 −26.731 1.00 52.94 C ATOM 3270 O GLU A 442 −43.740 −9.548 −25.951 1.00 54.86 O ATOM 3271 N VAL A 443 −42.798 −8.611 −27.759 1.00 48.31 N ATOM 3272 CA VAL A 443 −43.948 −7.818 −28.090 1.00 48.44 C ATOM 3273 CB VAL A 443 −43.500 −6.443 −28.587 1.00 46.57 C ATOM 3274 CG1 VAL A 443 −44.686 −5.529 −28.760 1.00 47.07 C ATOM 3275 CG2 VAL A 443 −42.523 −5.819 −27.626 1.00 45.33 C ATOM 3276 C VAL A 443 −44.773 −8.560 −29.178 1.00 52.94 C ATOM 3277 O VAL A 443 −44.205 −9.164 −30.131 1.00 53.72 O ATOM 3278 N GLU A 444 −46.103 −8.537 −29.019 1.00 54.13 N ATOM 3279 CA GLU A 444 −47.047 −9.141 −29.979 1.00 53.78 C ATOM 3280 CB GLU A 444 −47.419 −10.580 −29.556 1.00 55.76 C ATOM 3281 CG GLU A 444 −48.064 −11.435 −30.663 1.00 57.86 C ATOM 3282 CD GLU A 444 −48.277 −12.924 −30.300 1.00 57.93 C ATOM 3283 OE1 GLU A 444 −49.254 −13.544 −30.807 1.00 56.73 O ATOM 3284 OE2 GLU A 444 −47.474 −13.496 −29.520 1.00 57.27 O ATOM 3285 C GLU A 444 −48.306 −8.281 −30.057 1.00 53.56 C ATOM 3286 O GLU A 444 −48.933 −8.004 −29.028 1.00 53.68 O ATOM 3287 N GLU A 445 −48.672 −7.846 −31.262 1.00 54.13 N ATOM 3288 CA GLU A 445 −49.916 −7.084 −31.445 1.00 54.03 C ATOM 3289 CB GLU A 445 −50.031 −6.434 −32.830 1.00 53.51 C ATOM 3290 CG GLU A 445 −51.306 −5.617 −33.007 1.00 54.79 C ATOM 3291 CD GLU A 445 −51.366 4.828 −34.310 1.00 58.00 C ATOM 3292 OE1 GLU A 445 −52.492 −4.643 −34.885 1.00 60.21 O ATOM 3293 OE2 GLU A 445 −50.287 −4.369 −34.768 1.00 58.28 O ATOM 3294 C GLU A 445 −51.040 −8.048 −31.212 1.00 51.72 C ATOM 3295 O GLU A 445 −50.930 −9.171 −31.571 1.00 51.03 O ATOM 3296 N THR A 446 −52.097 −7.586 −30.576 1.00 55.50 N ATOM 3297 CA THR A 446 −53.188 −8.435 −30.115 1.00 59.27 C ATOM 3298 CB THR A 446 −52.783 −9.172 −28.799 1.00 57.95 C ATOM 3299 OG1 THR A 446 −53.440 −10.433 −28.752 1.00 63.57 O ATOM 3300 CG2 THR A 446 −53.138 −8.402 −27.551 1.00 56.45 C ATOM 3301 C THR A 446 −54.542 −7.657 −30.022 1.00 63.00 C ATOM 3302 O THR A 446 −54.607 −6.463 −30.335 1.00 66.09 O ATOM 3303 N GLU A 447 −55.617 −8.356 −29.654 1.00 68.01 N ATOM 3304 CA GLU A 447 −56.955 −7.755 −29.493 1.00 69.93 C ATOM 3305 CB GLU A 447 −58.045 −8.766 −29.926 1.00 69.48 C ATOM 3306 C GLU A 447 −57.056 −7.421 −28.004 1.00 72.84 C ATOM 3307 O GLU A 447 −56.452 −8.129 −27.189 1.00 69.69 O ATOM 3308 N LEU A 448 −57.743 −6.338 −27.627 1.00 75.59 N ATOM 3309 CA LEU A 448 −58.141 −6.178 −26.213 1.00 73.27 C ATOM 3310 CB LEU A 448 −57.555 −4.917 −25.571 1.00 70.29 C ATOM 3311 CG LEU A 448 −57.852 −4.706 −24.065 1.00 72.12 C ATOM 3312 CD1 LEU A 448 −57.611 −5.941 −23.211 1.00 73.39 C ATOM 3313 CD2 LEU A 448 −57.035 −3.579 −23.476 1.00 71.07 C ATOM 3314 C LEU A 448 −59.662 −6.168 −26.194 1.00 80.11 C ATOM 3315 O LEU A 448 −60.258 −5.209 −26.695 1.00 79.17 O ATOM 3316 N MET A 449 −60.293 −7.235 −25.660 1.00 84.58 N ATOM 3317 CA MET A 449 −61.754 −7.374 −25.759 1.00 86.05 C ATOM 3318 CB MET A 449 −62.286 −8.714 −25.237 1.00 91.93 C ATOM 3319 CG MET A 449 −63.802 −8.970 −25.466 1.00 97.86 C ATOM 3320 SD MET A 449 −64.487 −9.063 −27.165 1.00 103.28 S ATOM 3321 CE MET A 449 −65.484 −7.563 −27.375 1.00 102.24 C ATOM 3322 C MET A 449 −62.403 −6.228 −25.014 1.00 83.75 C ATOM 3323 O MET A 449 −62.104 −5.987 −23.840 1.00 81.25 O ATOM 3324 N GLY A 450 −63.251 −5.499 −25.745 1.00 79.77 N ATOM 3325 CA GLY A 450 −63.996 −4.397 −25.192 1.00 74.77 C ATOM 3326 C GLY A 450 −63.489 −3.105 −25.748 1.00 69.70 C ATOM 3327 O GLY A 450 −64.250 −2.140 −25.825 1.00 67.69 O ATOM 3328 N PHE A 451 −62.206 −3.078 −26.109 1.00 64.22 N ATOM 3329 CA PHE A 451 −61.631 −1.937 −26.793 1.00 62.05 C ATOM 3330 CB PHE A 451 −60.107 −1.814 −26.583 1.00 62.57 C ATOM 3331 CG PHE A 451 −59.671 −1.178 −25.296 1.00 62.39 C ATOM 3332 CD1 PHE A 451 −60.327 −1.398 −24.104 1.00 67.11 C ATOM 3333 CE1 PHE A 451 −59.875 −0.820 −22.913 1.00 68.34 C ATOM 3334 CZ PHE A 451 −58.725 −0.056 −22.899 1.00 67.44 C ATOM 3335 CE2 PHE A 451 −58.034 0.143 −24.086 1.00 66.05 C ATOM 3336 CD2 PHE A 451 −58.510 −0.431 −25.267 1.00 64.36 C ATOM 3337 C PHE A 451 −61.886 −2.109 −28.289 1.00 60.02 C ATOM 3338 O PHE A 451 −61.596 −3.118 −28.902 1.00 64.88 O ATOM 3339 N VAL A 452 −62.435 −1.088 −28.872 1.00 61.02 N ATOM 3340 CA VAL A 452 −62.602 −0.997 −30.278 1.00 62.03 C ATOM 3341 CB VAL A 452 −63.640 0.111 −30.491 1.00 64.11 C ATOM 3342 CG1 VAL A 452 −62.931 1.454 −30.574 1.00 66.83 C ATOM 3343 CG2 VAL A 452 −64.578 −0.154 −31.660 1.00 66.75 C ATOM 3344 C VAL A 452 −61.243 −0.680 −30.952 1.00 63.88 C ATOM 3345 O VAL A 452 −60.370 −0.073 −30.355 1.00 68.17 O ATOM 3346 N ASP A 453 −61.120 −1.068 −32.216 1.00 68.36 N ATOM 3347 CA ASP A 453 −59.873 −1.050 −33.039 1.00 68.59 C ATOM 3348 CB ASP A 453 −59.530 −2.496 −33.429 1.00 72.33 C ATOM 3349 CG ASP A 453 −60.680 −3.172 −34.219 1.00 81.47 C ATOM 3350 OD1 ASP A 453 −61.725 −3.629 −33.644 1.00 91.62 O ATOM 3351 OD2 ASP A 453 −60.561 −3.198 −35.444 1.00 83.04 O ATOM 3352 C ASP A 453 −59.972 −0.223 −34.346 1.00 65.04 C ATOM 3353 O ASP A 453 −58.958 0.155 −34.926 1.00 58.22 O ATOM 3354 N APS A 454 −61.195 0.044 −34.801 1.00 68.88 N ATOM 3355 CA APS A 454 −61.467 0.840 −36.010 1.00 71.17 C ATOM 3356 CB APS A 454 −62.700 0.273 −36.751 1.00 74.89 C ATOM 3357 CG APS A 454 −63.963 0.157 −35.870 1.00 75.95 C ATOM 3358 OD1 APS A 454 −63.860 0.192 −34.627 1.00 73.27 O ATOM 3359 OD2 APS A 454 −65.072 0.027 −36.450 1.00 77.95 O ATOM 3360 C APS A 454 −61.612 2.366 −35.754 1.00 73.44 C ATOM 3361 O APS A 454 −61.905 3.151 −36.683 1.00 67.75 O ATOM 3362 N GLN A 455 −61.359 2.778 −34.504 1.00 76.50 N ATOM 3363 CA GLN A 455 −61.435 4.166 −34.089 1.00 75.17 C ATOM 3364 CB GLN A 455 −62.582 4.291 −33.093 1.00 75.59 C ATOM 3365 CG GLN A 455 −63.958 4.003 −33.699 1.00 78.47 C ATOM 3366 CD GLN A 455 −64.450 5.113 −34.632 1.00 82.23 C ATOM 3367 OE1 GLN A 455 −63.789 6.143 −34.806 1.00 89.16 O ATOM 3368 NE2 GLN A 455 −65.625 4.914 −35.222 1.00 80.72 N ATOM 3369 C GLN A 455 −60.115 4.669 −33.479 1.00 73.82 C ATOM 3370 O GLN A 455 −59.434 3.928 −32.770 1.00 70.89 O ATOM 3371 N GLN A 456 −59.769 5.930 −33.778 1.00 74.82 N ATOM 3372 CA GLN A 456 −58.569 6.608 −33.219 1.00 68.71 C ATOM 3373 CB GLN A 456 −58.232 7.900 −33.985 1.00 64.68 C ATOM 3374 CG GLN A 456 −57.464 8.921 −33.155 1.00 67.04 C ATOM 3375 CD GLN A 456 −56.459 9.770 −33.924 1.00 73.95 C ATOM 3376 OE1 GLN A 456 −55.446 10.202 −33.349 1.00 77.29 O ATOM 3377 NE2 GLN A 456 −56.723 10.032 −35.208 1.00 74.87 N ATOM 3378 C GLN A 456 −58.708 6.911 −31.719 1.00 64.86 C ATOM 3379 O GLN A 456 −59.487 7.774 −31.323 1.00 66.79 O ATOM 3380 N THR A 457 −57.914 6.229 −30.903 1.00 58.17 N ATOM 3381 CA THR A 457 −57.893 6.483 −29.475 1.00 53.77 C ATOM 3382 CB THR A 457 −57.322 5.247 −28.739 1.00 46.86 C ATOM 3383 OG1 THR A 457 −58.203 4.161 −28.998 1.00 43.00 O ATOM 3384 CG2 THR A 457 −57.207 5.437 −27.221 1.00 42.63 C ATOM 3385 C THR A 457 −57.207 7.849 −29.120 1.00 56.21 C ATOM 3386 O THR A 457 −56.197 8.273 −29.768 1.00 48.43 O ATOM 3387 N PHE A 458 −57.840 8.536 −28.143 1.00 58.50 N ATOM 3388 CA PHE A 458 −57.344 9.792 −27.507 1.00 63.71 C ATOM 3389 CB PHE A 458 −58.404 10.942 −27.546 1.00 66.60 C ATOM 3390 CG PHE A 458 −58.690 11.481 −28.941 1.00 68.81 C ATOM 3391 CD1 PHE A 458 −57.672 11.858 −29.785 1.00 72.65 C ATOM 3392 CE1 PHE A 458 −57.931 12.326 −31.066 1.00 76.96 C ATOM 3393 CZ PHE A 458 −59.223 12.429 −31.513 1.00 79.83 C ATOM 3394 CE2 PHE A 458 −60.253 12.066 −30.676 1.00 79.37 C ATOM 3395 CD2 PHE A 458 −59.983 11.602 −29.399 1.00 75.30 C ATOM 3396 C PHE A 458 −56.860 9.603 −26.057 1.00 59.35 C ATOM 3397 O PHE A 458 −56.082 10.412 −25.527 1.00 58.20 O ATOM 3398 N PHE A 459 −57.336 8.565 −25.405 1.00 54.06 N ATOM 3399 CA PHE A 459 −56.763 8.172 −24.144 1.00 52.76 C ATOM 3400 CB PHE A 459 −57.161 9.158 −23.022 1.00 52.39 C ATOM 3401 CG PHE A 459 −56.781 8.678 −21.651 1.00 51.51 C ATOM 3402 CD1 PHE A 459 −57.508 7.665 −21.020 1.00 51.81 C ATOM 3403 CE1 PHE A 459 −57.107 7.167 −19.783 1.00 52.94 C ATOM 3404 CZ PHE A 459 −55.996 7.695 −19.154 1.00 50.03 C ATOM 3405 CE2 PHE A 459 −55.270 8.683 −19.777 1.00 49.18 C ATOM 3406 CD2 PHE A 459 −55.656 9.169 −21.017 1.00 50.02 C ATOM 3407 C PHE A 459 −57.226 6.752 −23.798 1.00 54.37 C ATOM 3408 O PHE A 459 −58.348 6.378 −24.056 1.00 58.85 O ATOM 3409 N CYS A 460 −56.356 5.953 −23.206 1.00 57.49 N ATOM 3410 CA CYS A 460 −56.800 4.795 −22.474 1.00 58.31 C ATOM 3411 CB CYS A 460 −56.859 3.590 −23.393 1.00 63.79 C ATOM 3412 SG CYS A 460 −55.264 3.174 −24.079 1.00 76.64 S ATOM 3413 C CYS A 460 −55.918 4.537 −21.265 1.00 56.34 C ATOM 3414 O CYS A 460 −54.885 5.196 −21.047 1.00 54.92 O ATOM 3415 N GLY A 461 −56.373 3.623 −20.438 1.00 55.51 N ATOM 3416 CA GLY A 461 −55.601 3.223 −19.303 1.00 62.01 C ATOM 3417 C GLY A 461 −56.449 2.649 −18.212 1.00 65.42 C ATOM 3418 O GLY A 461 −57.647 2.446 −18.391 1.00 61.81 O ATOM 3419 N ASN A 462 −55.804 2.429 −17.068 1.00 69.15 N ATOM 3420 CA ASN A 462 −56.491 1.959 −15.896 1.00 72.43 C ATOM 3421 CB ASN A 462 −55.530 1.398 −14.881 1.00 76.01 C ATOM 3422 CG ASN A 462 −54.733 0.268 −15.413 1.00 75.52 C ATOM 3423 OD1 ASN A 462 −55.231 −0.845 −15.588 1.00 70.68 O ATOM 3424 ND2 ASN A 462 −53.469 0.539 −15.657 1.00 81.51 N ATOM 3425 C ASN A 462 −57.241 3.078 −15.210 1.00 73.47 C ATOM 3426 O ASN A 462 −56.816 4.251 −15.211 1.00 68.37 O ATOM 3427 N VAL A 463 −58.331 2.675 −14.567 1.00 76.54 N ATOM 3428 CA VAL A 463 −59.189 3.601 −13.860 1.00 77.45 C ATOM 3429 CB VAL A 463 −60.251 4.200 −14.827 1.00 73.62 C ATOM 3430 CG1 VAL A 463 −59.672 5.375 −15.641 1.00 70.05 C ATOM 3431 CG2 VAL A 463 −60.802 3.125 −15.762 1.00 71.98 C ATOM 3432 C VAL A 463 −59.761 2.877 −12.639 1.00 78.42 C ATOM 3433 O VAL A 463 −59.678 1.645 −12.540 1.00 80.84 O ATOM 3434 N ALA A 464 −60.301 3.652 −11.704 1.00 82.57 N ATOM 3435 CA ALA A 464 −60.740 3.132 −10.397 1.00 88.14 C ATOM 3436 CB ALA A 464 −61.257 4.271 −9.522 1.00 86.99 C ATOM 3437 C ALA A 464 −61.783 2.006 −10.482 1.00 89.93 C ATOM 3438 O ALA A 464 −62.364 1.752 −11.542 1.00 −85.64 O ATOM 3439 N HIS A 465 −62.005 1.340 −9.348 1.00 92.45 N ATOM 3440 CA HIS A 465 −62.883 0.175 −9.279 1.00 90.92 C ATOM 3441 CB HIS A 465 −64.396 0.566 −9.366 1.00 90.71 C ATOM 3442 CG HIS A 465 −64.766 1.915 −8.789 1.00 93.76 C ATOM 3443 ND1 HIS A 465 −64.689 2.211 −7.442 1.00 94.95 N ATOM 3444 CE1 HIS A 465 −65.108 3.449 −7.236 1.00 91.23 C ATOM 3445 NE2 HIS A 465 −65.484 3.962 −8.396 1.00 87.66 N ATOM 3446 CD2 HIS A 465 −65.297 3.020 −9.380 1.00 89.83 C ATOM 3447 C HIS A 465 −62.521 −0.820 −10.418 1.00 89.87 C ATOM 3448 O HIS A 465 −63.310 −0.988 −11.334 1.00 92.92 O ATOM 3449 N GLN A 466 −61.324 −1.413 −10.397 1.00 86.34 N ATOM 3450 CA GLN A 466 −60.926 −2.525 −11.327 1.00 86.05 C ATOM 3451 CB GLN A 466 −61.311 −3.887 −10.734 1.00 90.40 C ATOM 3452 CG GLN A 466 −60.977 −4.104 −9.257 1.00 95.89 C ATOM 3453 CD GLN A 466 −59.659 −4.832 −9.043 1.00 96.46 C ATOM 3454 OE1 GLN A 466 −59.631 −6.008 −8.650 1.00 88.58 O ATOM 3455 NE2 GLN A 466 −58.559 −4.134 −9.294 1.00 96.20 N ATOM 3456 C GLN A 466 −61.426 −2.452 −12.806 1.00 82.21 C ATOM 3457 O GLN A 466 −62.078 −3.379 −13.324 1.00 76.09 O ATOM 3458 N GLN A 467 −61.084 −1.348 −13.477 1.00 81.73 N ATOM 3459 CA GLN A 467 −61.514 −1.066 −14.855 1.00 76.82 C ATOM 3460 CB GLN A 467 −62.729 −0.136 −14.854 1.00 83.56 C ATOM 3461 CG GLN A 467 −64.038 −0.839 −14.525 1.00 92.13 C ATOM 3462 CD GLN A 467 −65.185 0.109 −14.225 1.00 90.24 C ATOM 3463 OE1 GLN A 467 −65.020 1.118 −13.537 1.00 87.11 O ATOM 3464 NE2 GLN A 467 −66.367 −0.234 −14.726 1.00 92.54 N ATOM 3465 C GLN A 467 −60.455 −0.425 −15.740 1.00 69.88 C ATOM 3466 O GLN A 467 −59.466 0.163 −15.266 1.00 63.14 O ATOM 3467 N LEU A 468 −60.725 −0.568 −17.039 1.00 68.22 N ATOM 3468 CA LEU A 468 −59.992 0.025 −18.148 1.00 69.11 C ATOM 3469 CB LEU A 468 −59.616 −1.033 −19.201 1.00 69.21 C ATOM 3470 CG LEU A 468 −58.683 −2.143 −18.730 1.00 71.99 C ATOM 3471 CD1 LEU A 468 −58.443 −3.222 −19.775 1.00 70.08 C ATOM 3472 CD2 LEU A 468 −57.373 −1.505 −18.281 1.00 76.30 C ATOM 3473 C LEU A 468 −60.943 0.951 −18.820 1.00 67.99 C ATOM 3474 O LEU A 468 −62.108 0.609 −18.958 1.00 71.06 O ATOM 3475 N ILE A 469 −60.451 2.092 −19.271 1.00 66.25 N ATOM 3476 CA ILE A 469 −61.254 3.015 −20.060 1.00 70.78 C ATOM 3477 CB ILE A 469 −61.523 4.337 −19.276 1.00 73.05 C ATOM 3478 CG1 ILE A 469 −62.712 5.087 −19.885 1.00 72.05 C ATOM 3479 CD1 ILE A 469 −62.901 6.500 −19.389 1.00 72.86 C ATOM 3480 CG2 ILE A 469 −60.271 5.225 −19.192 1.00 75.98 C ATOM 3481 C ILE A 469 −60.528 3.262 −21.384 1.00 68.40 C ATOM 3482 O ILE A 469 −59.337 3.349 −21.391 1.00 74.21 O ATOM 3483 N GLN A 470 −61.242 3.337 −22.496 1.00 68.72 N ATOM 3484 CA GLN A 470 −60.683 3.799 −23.772 1.00 67.86 C ATOM 3485 CB GLN A 470 −60.754 2.679 −24.805 1.00 69.50 C ATOM 3486 CG GLN A 470 −60.024 2.997 −26.112 1.00 70.87 C ATOM 3487 CD GLN A 470 −60.373 2.091 −27.291 1.00 71.09 C ATOM 3488 OE1 GLN A 470 −59.909 2.319 −28.410 1.00 72.19 O ATOM 3489 NE2 GLN A 470 −61.159 1.069 −27.060 1.00 68.45 N ATOM 3490 C GLN A 470 −61.530 4.949 −24.263 1.00 64.13 C ATOM 3491 O GLN A 470 −62.726 4.877 −24.213 1.00 72.46 O ATOM 3492 N ILE A 471 −60.938 5.994 −24.779 1.00 60.99 N ATOM 3493 CA ILE A 471 −61.723 7.127 −25.256 1.00 64.27 C ATOM 3494 CB ILE A 471 −61.432 8.378 −24.416 1.00 62.44 C ATOM 3495 CG1 ILE A 471 −61.904 8.170 −22.987 1.00 62.39 C ATOM 3496 CD1 ILE A 471 −61.346 9.200 −22.038 1.00 63.28 C ATOM 3497 CG2 ILE A 471 −62.119 9.589 −25.007 1.00 63.59 C ATOM 3498 C ILE A 471 −61.433 7.393 −26.738 1.00 65.79 C ATOM 3499 O ILE A 471 −60.329 7.821 −27.089 1.00 67.88 O ATOM 3500 N THR A 472 −62.434 7.159 −27.584 1.00 66.46 N ATOM 3501 CA THR A 472 −62.283 7.256 −29.014 1.00 71.15 C ATOM 3502 CB THR A 472 −63.095 6.179 −29.738 1.00 79.58 C ATOM 3503 OG1 THR A 472 −64.489 6.312 −29.410 1.00 90.03 O ATOM 3504 CG2 THR A 472 −62.590 4.808 −29.336 1.00 81.15 C ATOM 3505 C THR A 472 −62.803 8.583 −29.426 1.00 69.90 C ATOM 3506 O THR A 472 −63.333 9.289 −28.597 1.00 67.70 O ATOM 3507 N SER A 473 −62.619 8.917 −30.713 1.00 74.95 N ATOM 3508 CA SER A 473 −63.275 10.076 −31.375 1.00 69.82 C ATOM 3509 CB SER A 473 −62.693 10.356 −32.778 1.00 66.25 C ATOM 3510 OG SER A 473 −62.446 9.146 −33.485 1.00 67.45 O ATOM 3511 C SER A 473 −64.770 9.800 −31.460 1.00 66.56 C ATOM 3512 O SER A 473 −65.573 10.711 −31.450 1.00 62.76 O ATOM 3513 N ALA A 474 −65.137 8.526 −31.509 1.00 65.03 N ATOM 3514 CA ALA A 474 −66.536 8.158 −31.490 1.00 62.64 C ATOM 3515 CB ALA A 474 −66.707 6.833 −32.208 1.00 65.15 C ATOM 3516 C ALA A 474 −67.196 8.096 −30.108 1.00 54.73 C ATOM 3517 O ALA A 474 −68.386 8.268 −30.029 1.00 58.36 O ATOM 3518 N SER A 475 −66.488 7.826 −29.035 0.50 47.34 N ATOM 3519 CA SER A 475 −67.201 7.465 −27.857 0.50 44.42 C ATOM 3520 CB SER A 475 −67.898 6.126 −28.060 0.50 41.91 C ATOM 3521 OG SER A 475 −66.942 5.089 −28.064 0.50 41.30 O ATOM 3522 C SER A 475 −66.243 7.327 −26.747 0.50 46.77 C ATOM 3523 O SER A 475 −65.050 7.466 −26.927 0.50 44.61 O ATOM 3524 N VAL A 476 −66.806 7.059 −25.582 1.00 52.05 N ATOM 3525 CA VAL A 476 −66.060 6.734 −24.363 1.00 57.75 C ATOM 3526 CB VAL A 476 −66.329 7.779 −23.232 1.00 57.85 C ATOM 3527 CG1 VAL A 476 −65.588 7.422 −21.949 1.00 58.87 C ATOM 3528 CG2 VAL A 476 −65.943 9.180 −23.670 1.00 58.26 C ATOM 3529 C VAL A 476 −66.415 5.298 −23.864 1.00 59.13 C ATOM 3530 O VAL A 476 −67.336 5.097 −23.104 1.00 56.11 O ATOM 3531 N ARG A 477 −65.634 4.311 −24.267 1.00 63.70 N ATOM 3532 CA ARG A 477 −65.831 2.933 −23.818 1.00 64.48 C ATOM 3533 CB ARG A 477 −65.277 1.991 −24.878 1.00 66.03 C ATOM 3534 CG ARG A 477 −65.984 2.217 −26.228 1.00 70.03 C ATOM 3535 CD ARG A 477 −65.343 1.471 −27.375 1.00 71.35 C ATOM 3536 NE ARG A 477 −65.518 0.047 −27.177 1.00 75.69 N ATOM 3537 CZ ARG A 477 −66.561 −0.666 −27.583 1.00 80.43 C ATOM 3538 NH1 ARG A 477 −67.572 −0.115 −28.251 1.00 84.67 N ATOM 3539 NH2 ARG A 477 −66.589 −1.963 −27.310 1.00 84.80 N ATOM 3540 C ARG A 477 −65.248 2.709 −22.410 1.00 63.87 C ATOM 3541 O ARG A 477 −64.381 3.439 −21.983 1.00 59.82 O ATOM 3542 N LEU A 478 −65.793 1.752 −21.666 1.00 63.07 N ATOM 3543 CA LEU A 478 −65.366 1.526 −20.291 1.00 63.21 C ATOM 3544 CB LEU A 478 −66.185 2.382 −19.320 1.00 62.60 C ATOM 3545 CG LEU A 478 −66.028 2.112 −17.801 1.00 61.30 C ATOM 3546 CD1 LEU A 478 −64.642 2.385 −17.241 1.00 60.32 C ATOM 3547 CD2 LEU A 478 −67.016 2.981 −17.074 1.00 62.73 C ATOM 3548 C LEU A 478 −65.519 0.064 −19.972 1.00 63.57 C ATOM 3549 O LEU A 478 −66.596 −0.472 −20.095 1.00 63.70 O ATOM 3550 N VAL A 479 −64.439 −0.561 −19.520 1.00 68.27 N ATOM 3551 CA VAL A 479 −64.252 −2.011 −19.675 1.00 72.02 C ATOM 3552 CB VAL A 479 −63.235 −2.307 −20.839 1.00 69.26 C ATOM 3553 CG1 VAL A 479 −62.916 −3.793 −20.955 1.00 69.10 C ATOM 3554 CG2 VAL A 479 −63.761 −1.784 −22.188 1.00 67.20 C ATOM 3555 C VAL A 479 −63.820 −2.643 −18.349 1.00 73.33 C ATOM 3556 O VAL A 479 −63.089 −2.044 −17.566 1.00 76.56 O ATOM 3557 N SER A 480 −64.298 −3.847 −18.098 1.00 74.88 N ATOM 3558 CA SER A 480 −64.008 −4.538 −16.857 1.00 79.98 C ATOM 3559 CB SER A 480 −65.060 −5.623 −16.629 1.00 79.45 C ATOM 3560 OG SER A 480 −65.340 −6.299 −17.842 1.00 76.52 O ATOM 3561 C SER A 480 −62.657 −5.183 −16.981 1.00 85.87 C ATOM 3562 O SER A 480 −62.285 −5.577 −18.077 1.00 87.77 O ATOM 3563 N GLN A 481 −61.941 −5.311 −15.861 1.00 95.89 N ATOM 3564 CA GLN A 481 −60.740 −6.175 −15.779 1.00 97.16 C ATOM 3565 CB GLN A 481 −59.952 −5.880 −14.525 1.00 100.28 C ATOM 3566 CG GLN A 481 −59.350 −4.496 −14.528 1.00 105.20 C ATOM 3567 CD GLN A 481 −57.976 −4.461 −15.166 1.00 103.65 C ATOM 3568 OE1 GLN A 481 −57.755 −4.989 −16.267 1.00 93.06 O ATOM 3569 NE2 GLN A 481 −57.032 −3.836 −14.462 1.00 104.34 N ATOM 3570 C GLN A 481 −61.067 −7.655 −15.760 1.00 99.60 C ATOM 3571 O GLN A 481 −60.551 −8.401 −16.576 1.00 93.92 O ATOM 3572 N GLU A 482 −61.912 −8.061 −14.809 1.00 109.91 N ATOM 3573 CA GLU A 482 −62.300 −9.464 −14.610 1.00 111.86 C ATOM 3574 CB GLU A 482 −62.702 −9.661 −13.135 1.00 119.75 C ATOM 3575 CG GLU A 482 −62.700 −11.097 −12.618 1.00 127.42 C ATOM 3576 CD GLU A 482 −61.399 −11.840 −12.914 1.00 128.99 C ATOM 3577 OE1 GLU A 482 −60.367 −11.170 −13.147 1.00 117.71 O ATOM 3578 OE2 GLU A 482 −61.408 −13.094 −12.914 1.00 128.98 O ATOM 3579 C GLU A 482 −63.435 −9.844 −15.582 1.00 109.44 C ATOM 3580 O GLU A 482 −64.564 −9.390 −15.411 1.00 100.16 O ATOM 3581 N PRO A 483 −63.161 −10.777 −16.533 1.00 112.39 N ATOM 3582 CA PRO A 483 −63.480 −10.750 −17.963 1.00 103.19 C ATOM 3583 CB PRO A 483 −64.782 −11.536 −18.021 1.00 107.09 C ATOM 3584 CG PRO A 483 −64.494 −12.653 −17.030 1.00 115.95 C ATOM 3585 CD PRO A 483 −63.364 −12.172 −16.095 1.00 118.58 C ATOM 3586 C PRO A 483 −63.562 −9.387 −18.603 1.00 94.45 C ATOM 3587 O PRO A 483 −63.824 −8.380 −17.941 1.00 87.76 O ATOM 3588 N LYS A 484 −63.264 −9.347 −19.890 1.00 90.10 N ATOM 3589 CA LYS A 484 −63.239 −8.076 −20.588 1.00 86.65 C ATOM 3590 CB LYS A 484 −61.936 −7.891 −21.372 1.00 83.73 C ATOM 3591 CG LYS A 484 −60.762 −7.486 −20.485 1.00 81.56 C ATOM 3592 CD LYS A 484 −59.490 −8.246 −20.830 1.00 84.99 C ATOM 3593 CE LYS A 484 −58.566 −8.422 −19.637 1.00 81.79 C ATOM 3594 NZ LYS A 484 −58.223 −7.100 −19.044 1.00 81.23 N ATOM 3595 C LYS A 484 −64.462 −7.992 −21.472 1.00 85.46 C ATOM 3596 O LYS A 484 −64.618 −8.770 −22.427 1.00 91.72 O ATOM 3597 N ALA A 485 −65.367 −7.097 −21.084 1.00 79.50 N ATOM 3598 CA ALA A 485 −66.332 −6.534 −22.015 1.00 79.39 C ATOM 3599 CB ALA A 485 −67.581 −7.399 −22.112 1.00 80.62 C ATOM 3600 C ALA A 485 −66.686 −5.088 −21.646 1.00 77.19 C ATOM 3601 O ALA A 485 −66.403 −4.601 −20.526 1.00 72.32 O ATOM 3602 N LEU A 486 −67.278 −4.407 −22.629 1.00 74.61 N ATOM 3603 CA LEU A 486 −67.900 −3.100 −22.425 1.00 74.26 C ATOM 3604 CB LEU A 486 −68.736 −2.708 −23.675 1.00 72.97 C ATOM 3605 CG LEU A 486 −68.891 −1.216 −24.026 1.00 74.79 C ATOM 3606 CD1 LEU A 486 −67.496 −0.652 −24.284 1.00 82.22 C ATOM 3607 CD2 LEU A 486 −69.786 −0.889 −25.225 1.00 71.33 C ATOM 3608 C LEU A 486 −68.806 −3.217 −21.198 1.00 78.02 C ATOM 3609 O LEU A 486 −69.595 −4.166 −21.128 1.00 87.07 O ATOM 3610 N VAL A 487 −68.664 −2.336 −20.205 1.00 75.30 N ATOM 3611 CA VAL A 487 −69.667 −2.261 −19.123 1.00 72.80 C ATOM 3612 CB VAL A 487 −69.115 −2.649 −17.698 1.00 74.60 C ATOM 3613 CG1 VAL A 487 −68.662 −4.114 −17.634 1.00 73.18 C ATOM 3614 CG2 VAL A 487 −67.982 −1.746 −17.242 1.00 77.36 C ATOM 3615 C VAL A 487 −70.410 −0.913 −19.145 1.00 69.50 C ATOM 3616 O VAL A 487 −71.245 −0.659 −18.273 1.00 71.87 O ATOM 3617 N SER A 488 −70.168 −0.103 −20.175 1.00 66.45 N ATOM 3618 CA SER A 488 −70.663 1.276 −20.241 1.00 73.61 C ATOM 3619 CB SER A 488 −70.095 2.122 −19.107 1.00 75.10 C ATOM 3620 OG SER A 488 −70.889 2.053 −17.951 1.00 85.22 O ATOM 3621 C SER A 488 −70.172 1.943 −21.492 1.00 76.45 C ATOM 3622 O SER A 488 −69.072 1.647 −21.917 1.00 87.45 O ATOM 3623 N GLU A 489 −70.937 2.884 −22.035 1.00 72.34 N ATOM 3624 CA GLU A 489 −70.469 3.720 −23.139 1.00 70.12 C ATOM 3625 CB GLU A 489 −70.575 2.986 −24.496 1.00 72.77 C ATOM 3626 CG GLU A 489 −70.153 3.822 −25.720 1.00 76.03 C ATOM 3627 CD GLU A 489 −69.747 3.004 −26.948 1.00 75.70 C ATOM 3628 OE1 GLU A 489 −68.774 3.393 −27.643 1.00 72.20 O ATOM 3629 OE2 GLU A 489 −70.393 1.973 −27.222 1.00 80.05 O ATOM 3630 C GLU A 489 −71.227 5.042 −23.128 1.00 68.87 C ATOM 3631 O GLU A 489 −72.354 5.118 −22.683 1.00 74.47 O ATOM 3632 N TRP A 490 −70.583 6.090 −23.593 1.00 68.64 N ATOM 3633 CA TRP A 490 −71.100 7.427 −23.509 1.00 68.15 C ATOM 3634 CB TRP A 490 −70.232 8.208 −22.529 1.00 65.75 C ATOM 3635 CG TRP A 490 −70.722 9.500 −22.305 1.00 68.72 C ATOM 3636 CD1 TRP A 490 −71.548 9.866 −21.320 1.00 73.62 C ATOM 3637 NE1 TRP A 490 −71.853 11.208 −21.439 1.00 80.51 N ATOM 3638 CE2 TRP A 490 −71.205 11.726 −22.533 1.00 78.90 C ATOM 3639 CD2 TRP A 490 −70.484 10.675 −23.113 1.00 75.99 C ATOM 3640 CE3 TRP A 490 −69.716 10.942 −24.270 1.00 79.27 C ATOM 3641 CZ3 TRP A 490 −69.704 12.246 −24.803 1.00 76.05 C ATOM 3642 CH2 TRP A 490 −70.435 13.261 −24.198 1.00 79.73 C ATOM 3643 CZ2 TRP A 490 −71.189 13.032 −23.064 1.00 80.00 C ATOM 3644 C TRP A 490 −70.983 7.986 −24.906 1.00 72.80 C ATOM 3645 O TRP A 490 −69.889 8.027 −25.444 1.00 77.47 O ATOM 3646 N LYS A 491 −72.081 8.403 −25.515 1.00 80.84 N ATOM 3647 CA LYS A 491 −72.013 8.971 −26.853 1.00 89.00 C ATOM 3648 CB LYS A 491 −73.000 8.250 −27.778 1.00 102.16 C ATOM 3649 CG LYS A 491 −72.755 8.531 −29.260 1.00 111.87 C ATOM 3650 CD LYS A 491 −73.396 7.506 −30.185 1.00 113.83 C ATOM 3651 CE LYS A 491 −73.335 7.983 −31.630 1.00 112.89 C ATOM 3652 NZ LYS A 491 −73.190 6.838 −32.570 1.00 113.93 N ATOM 3653 C LYS A 491 −72.303 10.460 −26.800 1.00 89.29 C ATOM 3654 O LYS A 491 −72.926 10.952 −25.853 1.00 85.94 O ATOM 3655 N GLU A 492 −71.849 11.182 −27.819 1.00 91.24 N ATOM 3656 CA GLU A 492 −72.255 12.576 −27.982 1.00 94.12 C ATOM 3657 CB GLU A 492 −71.339 13.281 −28.972 1.00 97.74 C ATOM 3658 CG GLU A 492 −71.279 14.804 −28.789 1.00 102.93 C ATOM 3659 CD GLU A 492 −72.443 15.597 −29.404 1.00 99.62 C ATOM 3660 OE1 GLU A 492 −73.227 15.048 −30.226 1.00 88.25 O ATOM 3661 OE2 GLU A 492 −72.542 16.808 −29.069 1.00 93.30 O ATOM 3662 C GLU A 492 −73.709 12.663 −28.483 1.00 92.42 C ATOM 3663 O GLU A 492 −74.021 12.050 −29.497 1.00 87.99 O ATOM 3664 N PRO A 493 −74.588 13.441 −27.796 1.00 94.54 N ATOM 3665 CA PRO A 493 −76.002 13.608 −28.158 1.00 91.43 C ATOM 3666 CB PRO A 493 −76.336 14.977 −27.574 1.00 95.75 C ATOM 3667 CG PRO A 493 −75.550 14.996 −26.301 1.00 100.25 C ATOM 3668 CD PRO A 493 −74.306 14.156 −26.531 1.00 99.11 C ATOM 3669 C PRO A 493 −76.348 13.513 −29.648 1.00 91.45 C ATOM 3670 O PRO A 493 −76.970 12.532 −30.031 1.00 90.86 O ATOM 3671 N GLN A 494 −75.927 14.457 −30.497 1.00 93.41 N ATOM 3672 CA GLN A 494 −76.245 14.386 −31.946 1.00 91.82 C ATOM 3673 CB GLN A 494 −76.544 15.796 −32.527 1.00 84.49 C ATOM 3674 C GLN A 494 −75.145 13.608 −32.738 1.00 93.36 C ATOM 3675 O GLN A 494 −74.852 13.949 −33.891 1.00 89.69 O ATOM 3676 N ALA A 495 −74.590 12.547 −32.109 1.00 100.85 N ATOM 3677 CA ALA A 495 −73.475 11.656 −32.607 1.00 102.09 C ATOM 3678 CB ALA A 495 −74.021 10.630 −33.606 1.00 99.89 C ATOM 3679 C ALA A 495 −72.167 12.304 −33.153 1.00 99.20 C ATOM 3680 O ALA A 495 −71.498 11.707 −34.005 1.00 94.90 O ATOM 3681 N LYS A 496 −71.790 13.482 −32.636 1.00 97.64 N ATOM 3682 CA LYS A 496 −70.618 14.239 −33.153 1.00 93.62 C ATOM 3683 CB LYS A 496 −70.691 15.794 −32.931 1.00 102.05 C ATOM 3684 CG LYS A 496 −72.031 16.505 −32.603 1.00 106.55 C ATOM 3685 CD LYS A 496 −72.343 17.731 −33.468 1.00 109.99 C ATOM 3686 CE LYS A 496 −73.135 17.315 −34.717 1.00 116.83 C ATOM 3687 NZ LYS A 496 −72.813 18.104 −35.937 1.00 124.14 N ATOM 3688 C LYS A 496 −69.337 13.697 −32.502 1.00 84.20 C ATOM 3689 O LYS A 496 −69.375 13.215 −31.370 1.00 88.31 O ATOM 3690 N ASN A 497 −68.203 13.800 −33.183 1.00 72.73 N ATOM 3691 CA ASN A 497 −66.949 13.323 −32.600 1.00 70.33 C ATOM 3692 CB ASN A 497 −65.814 13.355 −33.623 1.00 72.29 C ATOM 3693 CG ASN A 497 −66.014 12.402 −34.771 1.00 74.24 C ATOM 3694 OD1 ASN A 497 −66.547 11.277 −34.636 1.00 74.43 O ATOM 3695 ND2 ASN A 497 −65.562 12.844 −35.928 1.00 73.26 N ATOM 3696 C ASN A 497 −66.423 14.122 −31.397 1.00 67.55 C ATOM 3697 O ASN A 497 −66.214 15.325 −31.518 1.00 63.69 O ATOM 3698 N ILE A 498 −66.157 13.425 −30.279 1.00 66.83 N ATOM 3699 CA ILE A 498 −65.149 13.842 −29.266 1.00 65.78 C ATOM 3700 CB ILE A 498 −64.729 12.678 −28.304 1.00 64.55 C ATOM 3701 CG1 ILE A 498 −65.906 12.163 −27.451 1.00 61.88 C ATOM 3702 CD1 ILE A 498 −66.054 10.655 −27.475 1.00 60.24 C ATOM 3703 CG2 ILE A 498 −63.631 13.116 −27.332 1.00 65.36 C ATOM 3704 C ILE A 498 −63.899 14.389 −29.996 1.00 65.97 C ATOM 3705 O ILE A 498 −63.366 13.742 −30.908 1.00 64.21 O ATOM 3706 N SER A 499 −63.461 15.597 −29.629 1.00 69.37 N ATOM 3707 CA SER A 499 −62.348 16.268 −30.356 1.00 70.19 C ATOM 3708 CB SER A 499 −62.808 17.623 −30.979 1.00 70.69 C ATOM 3709 OG SER A 499 −62.139 18.777 −30.494 1.00 71.57 O ATOM 3710 C SER A 499 −61.044 16.365 −29.544 1.00 64.91 C ATOM 3711 O SER A 499 −59.980 16.310 −30.150 1.00 63.81 O ATOM 3712 N VAL A 500 −61.154 16.494 −28.210 1.00 60.37 N ATOM 3713 CA VAL A 500 −60.042 16.469 −27.263 1.00 59.06 C ATOM 3714 CB VAL A 500 −59.776 17.846 −26.682 1.00 65.63 C ATOM 3715 CG1 VAL A 500 −58.783 17.775 −25.522 1.00 70.96 C ATOM 3716 CG2 VAL A 500 −59.262 18.790 −27.768 1.00 69.69 C ATOM 3717 C VAL A 500 −60.457 15.669 −26.089 1.00 56.86 C ATOM 3718 O VAL A 500 −61.585 15.770 −25.700 1.00 56.23 O ATOM 3719 N ALA A 501 −59.541 14.919 −25.486 1.00 59.09 N ATOM 3720 CA ALA A 501 −59.883 14.120 −24.307 1.00 59.74 C ATOM 3721 CB ALA A 501 −60.104 12.687 −24.709 1.00 60.06 C ATOM 3722 C ALA A 501 −58.828 14.196 −23.224 1.00 59.76 C ATOM 3723 O ALA A 501 −57.675 14.475 −23.491 1.00 57.16 O ATOM 3724 N SER A 502 −59.244 13.948 −21.994 1.00 64.53 N ATOM 3725 CA SER A 502 −58.337 13.957 −20.845 1.00 70.79 C ATOM 3726 CB SER A 502 −57.929 15.384 −20.416 1.00 76.96 C ATOM 3727 OG SER A 502 −59.048 16.197 −20.031 1.00 85.43 O ATOM 3728 C SER A 502 −59.023 13.242 −19.694 1.00 67.80 C ATOM 3729 O SER A 502 −60.055 13.688 −19.201 1.00 68.62 O ATOM 3730 N CYS A 503 −58.438 12.128 −19.290 1.00 64.75 N ATOM 3731 CA CYS A 503 −58.965 11.325 −18.251 1.00 62.56 C ATOM 3732 CB CYS A 503 −59.415 10.017 −18.841 1.00 62.26 C ATOM 3733 SG CYS A 503 −59.530 8.681 −17.652 1.00 73.07 S ATOM 3734 C CYS A 503 −57.866 11.142 −17.222 1.00 65.83 C ATOM 3735 O CYS A 503 −56.685 11.305 −17.510 1.00 66.73 O ATOM 3736 N ASN A 504 −58.298 10.882 −15.995 1.00 71.30 N ATOM 3737 CA ASN A 504 −57.428 10.579 −14.860 1.00 71.01 C ATOM 3738 CB ASN A 504 −57.232 11.836 −13.915 1.00 73.53 C ATOM 3739 CG ASN A 504 −58.416 12.135 −12.935 1.00 76.23 C ATOM 3740 OD1 ASN A 504 −58.628 11.438 −11.929 1.00 80.87 O ATOM 3741 ND2 ASN A 504 −59.117 13.250 −13.182 1.00 74.10 N ATOM 3742 C ASN A 504 −57.928 9.292 −14.165 1.00 69.28 C ATOM 3743 O ASN A 504 −58.714 8.538 −14.718 1.00 72.96 O ATOM 3744 N SER A 505 −57.414 9.023 −12.980 1.00 71.93 N ATOM 3745 CA SER A 505 −57.868 7.936 −12.103 1.00 71.16 C ATOM 3746 CB SER A 505 −57.449 8.313 −10.681 1.00 70.79 C ATOM 3747 OG SER A 505 −56.630 7.303 −10.183 1.00 74.95 O ATOM 3748 C SER A 505 −59.377 7.597 −12.098 1.00 75.17 C ATOM 3749 O SER A 505 −59.746 6.429 −12.157 1.00 71.95 O ATOM 3750 N SER A 506 −60.213 8.650 −12.029 1.00 83.38 N ATOM 3751 CA SER A 506 −61.639 8.605 −11.630 1.00 80.15 C ATOM 3752 CB SER A 506 −61.705 8.939 −10.130 1.00 79.96 C ATOM 3753 OG SER A 506 −61.284 10.292 −9.901 1.00 74.12 O ATOM 3754 C SER A 506 −62.563 9.623 −12.350 1.00 79.81 C ATOM 3755 O SER A 506 −63.704 9.802 −11.921 1.00 79.84 O ATOM 3756 N GLN A 507 −62.102 10.251 −13.442 1.00 80.58 N ATOM 3757 CA GLN A 507 −62.626 11.566 −13.896 1.00 77.76 C ATOM 3758 CB GLN A 507 −61.995 12.651 −13.025 1.00 78.21 C ATOM 3759 CG GLN A 507 −62.704 13.004 −11.751 1.00 79.11 C ATOM 3760 CD GLN A 507 −62.143 14.293 −11.190 1.00 77.48 C ATOM 3761 OE1 GLN A 507 −61.042 14.319 −10.642 1.00 84.73 O ATOM 3762 NE2 GLN A 507 −62.880 15.373 −11.353 1.00 70.09 N ATOM 3763 C GLN A 507 −62.323 11.966 −15.346 1.00 71.79 C ATOM 3764 O GLN A 507 −61.256 12.538 −15.615 1.00 66.06 O ATOM 3765 N VAL A 508 −63.271 11.732 −16.249 1.00 69.24 N ATOM 3766 CA VAL A 508 −63.103 12.094 −17.667 1.00 72.60 C ATOM 3767 CB VAL A 508 −64.017 11.264 −18.590 1.00 79.75 C ATOM 3768 CG1 VAL A 508 −63.850 11.677 −20.062 1.00 83.13 C ATOM 3769 CG2 VAL A 508 −63.795 9.758 −18.412 1.00 79.96 C ATOM 3770 C VAL A 508 −63.494 13.547 −17.856 1.00 70.13 C ATOM 3771 O VAL A 508 −64.250 14.047 −17.074 1.00 69.27 O ATOM 3772 N VAL A 509 −62.944 14.211 −18.868 1.00 68.53 N ATOM 3773 CA VAL A 509 −63.385 15.534 −19.319 1.00 71.69 C ATOM 3774 CB VAL A 509 −62.632 16.712 −18.635 1.00 74.99 C ATOM 3775 CG1 VAL A 509 −63.235 18.067 −19.016 1.00 72.01 C ATOM 3776 CG2 VAL A 509 −62.666 16.568 −17.142 1.00 78.59 C ATOM 3777 C VAL A 509 −63.086 15.619 −20.805 1.00 72.45 C ATOM 3778 O VAL A 509 −62.015 16.105 −21.209 1.00 68.54 O ATOM 3779 N VAL A 510 −64.011 15.102 −21.609 1.00 72.64 N ATOM 3780 CA VAL A 510 −63.942 15.245 −23.077 1.00 71.94 C ATOM 3781 CB VAL A 510 −64.798 14.210 −23.857 1.00 74.07 C ATOM 3782 CG1 VAL A 510 −64.077 12.874 −23.990 1.00 73.20 C ATOM 3783 CG2 VAL A 510 −66.180 14.068 −23.228 1.00 76.51 C ATOM 3784 C VAL A 510 −64.395 16.645 −23.449 1.00 70.68 C ATOM 3785 O VAL A 510 −64.727 17.447 −22.583 1.00 68.96 O ATOM 3786 N ALA A 511 −64.365 16.922 −24.744 1.00 72.63 N ATOM 3787 CA ALA A 511 −64.621 18.228 −25.291 1.00 76.13 C ATOM 3788 CB ALA A 511 −63.397 19.112 −25.141 1.00 72.42 C ATOM 3789 C ALA A 511 −64.950 18.015 −26.760 1.00 85.73 C ATOM 3790 O ALA A 511 −64.191 17.379 −27.504 1.00 84.09 O ATOM 3791 N VAL A 512 −66.104 18.525 −27.166 1.00 92.76 N ATOM 3792 CA VAL A 512 −66.588 18.374 −28.522 1.00 88.98 C ATOM 3793 CB VAL A 512 −67.969 17.707 −28.508 1.00 84.67 C ATOM 3794 CG1 VAL A 512 −68.277 17.119 −29.869 1.00 84.55 C ATOM 3795 CG2 VAL A 512 −68.026 16.612 −27.447 1.00 84.32 C ATOM 3796 C VAL A 512 −66.628 19.784 −29.121 1.00 93.45 C ATOM 3797 O VAL A 512 −67.331 20.653 −28.593 1.00 96.51 O ATOM 3798 N GLY A 513 −65.833 20.005 −30.179 1.00 93.03 N ATOM 3799 CA GLY A 513 −65.684 21.304 −30.862 1.00 94.29 C ATOM 3800 C GLY A 513 −65.484 22.529 −29.978 1.00 95.34 C ATOM 3801 O GLY A 513 −64.360 22.822 −29.594 1.00 91.49 O ATOM 3802 N ARG A 514 −66.580 23.253 −29.701 1.00 99.84 N ATOM 3803 CA ARG A 514 −66.630 24.356 −28.694 1.00 102.40 C ATOM 3804 CB ARG A 514 −67.419 25.582 −29.250 1.00 104.04 C ATOM 3805 CG ARG A 514 −66.648 26.464 −30.262 1.00 103.36 C ATOM 3806 CD ARG A 514 −67.516 27.344 −31.166 1.00 98.31 C ATOM 3807 NE ARG A 514 −68.453 28.116 −30.359 1.00 101.61 N ATOM 3808 CZ ARG A 514 −69.722 27.783 −30.078 1.00 102.60 C ATOM 3809 NH1 ARG A 514 −70.282 26.672 −30.556 1.00 100.55 N ATOM 3810 NH2 ARG A 514 −70.461 28.592 −29.311 1.00 100.16 N ATOM 3811 C ARG A 514 −67.198 23.904 −27.313 1.00 95.36 C ATOM 3812 O ARG A 514 −66.892 24.519 −26.276 1.00 85.61 O ATOM 3813 N ALA A 515 −67.996 22.828 −27.327 1.00 92.01 N ATOM 3814 CA ALA A 515 −68.682 22.276 −26.149 1.00 90.43 C ATOM 3815 CB ALA A 515 −69.896 21.479 −26.604 1.00 89.80 C ATOM 3816 C ALA A 515 −67.760 21.380 −25.331 1.00 90.00 C ATOM 3817 O ALA A 515 −66.802 20.825 −25.900 1.00 89.18 O ATOM 3818 N LEU A 516 −68.025 21.242 −24.017 1.00 84.50 N ATOM 3819 CA LEU A 516 −67.271 20.279 −23.187 1.00 82.11 C ATOM 3820 CB LEU A 516 −65.882 20.804 −22.786 1.00 82.78 C ATOM 3821 CG LEU A 516 −65.529 21.939 −21.805 1.00 90.10 C ATOM 3822 CD1 LEU A 516 −65.637 21.621 −20.292 1.00 91.44 C ATOM 3823 CD2 LEU A 516 −64.097 22.375 −22.150 1.00 92.01 C ATOM 3824 C LEU A 516 −67.993 19.696 −21.981 1.00 81.92 C ATOM 3825 O LEU A 516 −68.300 20.388 −21.035 1.00 84.97 O ATOM 3826 N TYR A 517 −68.191 18.382 −22.016 1.00 86.25 N ATOM 3827 CA TYR A 517 −68.903 17.632 −20.975 1.00 87.50 C ATOM 3828 CB TYR A 517 −69.667 16.441 −21.580 1.00 91.55 C ATOM 3829 CG TYR A 517 −70.495 16.809 −22.796 1.00 101.13 C ATOM 3830 CD1 TYR A 517 −69.929 16.796 −24.067 1.00 108.62 C ATOM 3831 CE1 TYR A 517 −70.669 17.137 −25.191 1.00 115.17 C ATOM 3832 CZ TYR A 517 −71.991 17.507 −25.064 1.00 113.92 C ATOM 3833 OH TYR A 517 −72.657 17.834 −26.223 1.00 114.74 O ATOM 3834 CE2 TYR A 517 −72.592 17.538 −23.811 1.00 110.65 C ATOM 3835 CD2 TYR A 517 −71.840 17.193 −22.683 1.00 108.07 C ATOM 3836 C TYR A 517 −67.885 17.139 −19.963 1.00 80.78 C ATOM 3837 O TYR A 517 −66.690 17.104 −20.251 1.00 77.59 O ATOM 3838 N TYR A 518 −68.369 16.743 −18.788 1.00 78.22 N ATOM 3839 CA TYR A 518 −67.514 16.291 −17.686 1.00 74.79 C ATOM 3840 CB TYR A 518 −67.255 17.462 −16.697 1.00 71.65 C ATOM 3841 CG TYR A 518 −66.871 17.006 −15.311 1.00 74.75 C ATOM 3842 CD1 TYR A 518 −65.889 16.072 −15.127 1.00 79.29 C ATOM 3843 CE1 TYR A 518 −65.553 15.608 −13.863 1.00 79.97 C ATOM 3844 CZ TYR A 518 −66.185 16.085 −12.770 1.00 75.30 C ATOM 3845 OH TYR A 518 −65.808 15.620 −11.567 1.00 72.23 O ATOM 3846 CE2 TYR A 518 −67.178 17.004 −12.904 1.00 79.34 C ATOM 3847 CD2 TYR A 518 −67.525 17.459 −14.180 1.00 81.79 C ATOM 3848 C TYR A 518 −68.097 15.025 −16.995 1.00 72.37 C ATOM 3849 O TYR A 518 −68.889 15.114 −16.071 1.00 76.08 O ATOM 3850 N LEU A 519 −67.645 13.847 −17.409 1.00 70.81 N ATOM 3851 CA LEU A 519 −68.111 12.583 −16.824 1.00 70.42 C ATOM 3852 CB LEU A 519 −68.021 11.478 −17.863 1.00 73.22 C ATOM 3853 CG LEU A 519 −68.859 11.562 −19.147 1.00 77.42 C ATOM 3854 CD1 LEU A 519 −69.177 12.966 −19.681 1.00 75.71 C ATOM 3855 CD2 LEU A 519 −68.179 10.703 −20.213 1.00 80.14 C ATOM 3856 C LEU A 519 −67.266 12.144 −15.635 1.00 66.77 C ATOM 3857 O LEU A 519 −66.084 12.463 −15.570 1.00 61.74 O ATOM 3858 N GLN A 520 −67.858 11.364 −14.734 1.00 69.00 N ATOM 3859 CA GLN A 520 −67.090 10.630 −13.695 1.00 73.53 C ATOM 3860 CB GLN A 520 −67.466 11.056 −12.268 1.00 77.61 C ATOM 3861 CG GLN A 520 −67.206 12.524 −11.920 1.00 82.46 C ATOM 3862 CD GLN A 520 −67.400 12.813 −10.429 1.00 83.51 C ATOM 3863 OE1 GLN A 520 −68.229 12.197 −9.744 1.00 87.64 O ATOM 3864 NE2 GLN A 520 −66.622 13.738 −9.919 1.00 81.66 N ATOM 3865 C GLN A 520 −67.251 9.111 −13.799 1.00 72.90 C ATOM 3866 O GLN A 520 −68.271 8.621 −14.279 1.00 63.72 O ATOM 3867 N ILE A 521 −66.233 8.399 −13.298 1.00 77.64 N ATOM 3868 CA ILE A 521 −66.153 6.935 −13.348 1.00 82.90 C ATOM 3869 CB ILE A 521 −64.729 6.421 −13.766 1.00 88.24 C ATOM 3870 CG1 ILE A 521 −64.403 6.854 −15.217 1.00 89.72 C ATOM 3871 CD1 ILE A 521 −62.977 7.329 −15.424 1.00 90.86 C ATOM 3872 CG2 ILE A 521 −64.591 4.886 −13.631 1.00 83.79 C ATOM 3873 C ILE A 521 −66.544 6.385 −11.987 1.00 81.54 C ATOM 3874 O ILE A 521 −65.951 6.750 −10.960 1.00 77.33 O ATOM 3875 N HIS A 522 −67.582 5.549 −12.008 1.00 84.50 N ATOM 3876 CA HIS A 522 −68.031 4.779 −10.848 1.00 90.44 C ATOM 3877 CB HIS A 522 −69.317 5.397 −10.229 1.00 94.15 C ATOM 3878 CG HIS A 522 −69.170 6.847 −9.832 1.00 98.97 C ATOM 3879 ND1 HIS A 522 −68.735 7.243 −8.582 1.00 100.75 N ATOM 3880 CE1 HIS A 522 −68.691 8.565 −8.526 1.00 100.41 C ATOM 3881 NE2 HIS A 522 −69.074 9.043 −9.696 1.00 99.16 N ATOM 3882 CD2 HIS A 522 −69.380 7.992 −10.531 1.00 99.45 C ATOM 3883 C HIS A 522 −68.217 3.347 −11.377 1.00 83.18 C ATOM 3884 O HIS A 522 −68.106 3.144 −12.596 1.00 77.20 O ATOM 3885 N PRO A 523 −68.474 2.353 −10.486 1.00 75.96 N ATOM 3886 CA PRO A 523 −68.521 0.997 −11.014 1.00 72.38 C ATOM 3887 CB PRO A 523 −68.780 0.113 −9.766 1.00 70.83 C ATOM 3888 CG PRO A 523 −68.402 0.954 −8.615 1.00 73.30 C ATOM 3889 CD PRO A 523 −68.709 2.371 −9.030 1.00 75.91 C ATOM 3890 C PRO A 523 −69.596 0.858 −12.099 1.00 71.47 C ATOM 3891 O PRO A 523 −70.633 1.485 −12.033 1.00 68.82 O ATOM 3892 N GLN A 524 −69.269 0.085 −13.127 1.00 78.14 N ATOM 3893 CA GLN A 524 −70.118 −0.227 −14.287 1.00 78.23 C ATOM 3894 CB GLN A 524 −70.941 −1.480 −13.976 1.00 77.28 C ATOM 3895 CG GLN A 524 −70.068 −2.702 −13.746 1.00 77.64 C ATOM 3896 CD GLN A 524 −69.590 −2.881 −12.307 1.00 78.32 C ATOM 3897 OE1 GLN A 524 −69.518 −1.947 −11.527 1.00 71.64 O ATOM 3898 NE2 GLN A 524 −69.261 −4.116 −11.958 1.00 84.97 N ATOM 3899 C GLN A 524 −70.991 0.907 −14.846 1.00 78.54 C ATOM 3900 O GLN A 524 −72.031 0.652 −15.470 1.00 80.73 O ATOM 3901 N GLU A 525 −70.538 2.148 −14.674 1.00 78.26 N ATOM 3902 CA GLU A 525 −71.321 3.318 −15.081 1.00 80.75 C ATOM 3903 CB GLU A 525 −72.547 3.555 −14.152 1.00 86.78 C ATOM 3904 CG GLU A 525 −72.329 4.187 −12.762 1.00 84.23 C ATOM 3905 CD GLU A 525 −72.814 5.630 −12.664 1.00 76.79 C ATOM 3906 OE1 GLU A 525 −74.011 5.863 −12.879 1.00 65.27 O ATOM 3907 OE2 GLU A 525 −72.002 6.525 −12.353 1.00 78.67 O ATOM 3908 C GLU A 525 −70.437 4.538 −15.182 1.00 77.54 C ATOM 3909 O GLU A 525 −69.570 4.758 −14.326 1.00 71.85 O ATOM 3910 N LEU A 526 −70.625 5.284 −16.268 1.00 83.99 N ATOM 3911 CA LEU A 526 −69.955 6.577 −16.454 1.00 95.32 C ATOM 3912 CB LEU A 526 −68.923 6.636 −17.617 1.00 96.59 C ATOM 3913 CG LEU A 526 −68.873 5.607 −18.750 1.00 100.01 C ATOM 3914 CD1 LEU A 526 −70.077 5.668 −19.680 1.00 103.94 C ATOM 3915 CD2 LEU A 526 −67.599 5.858 −19.524 1.00 100.98 C ATOM 3916 C LEU A 526 −71.040 7.637 −16.569 1.00 93.82 C ATOM 3917 O LEU A 526 −71.667 7.813 −17.638 1.00 87.46 O ATOM 3918 N ARG A 527 −71.232 8.345 −15.460 1.00 92.64 N ATOM 3919 CA ARG A 527 −72.241 9.373 −15.315 1.00 91.65 C ATOM 3920 CB ARG A 527 −72.714 9.387 −13.872 1.00 90.52 C ATOM 3921 CG ARG A 527 −71.576 9.393 −12.884 1.00 91.26 C ATOM 3922 CD ARG A 527 −72.084 9.441 −11.458 1.00 90.48 C ATOM 3923 NE ARG A 527 −72.717 8.196 −11.050 1.00 85.80 N ATOM 3924 CZ ARG A 527 −72.877 7.838 −9.785 1.00 77.95 C ATOM 3925 NH1 ARG A 527 −72.434 8.619 −8.815 1.00 78.63 N ATOM 3926 NH2 ARG A 527 −73.465 6.699 −9.491 1.00 68.78 N ATOM 3927 C ARG A 527 −71.806 10.771 −15.670 1.00 90.34 C ATOM 3928 O ARG A 527 −70.775 11.238 −15.239 1.00 88.51 O ATOM 3929 N GLN A 528 −72.627 11.433 −16.464 1.00 85.80 N ATOM 3930 CA GLN A 528 −72.385 12.790 −16.875 1.00 81.72 C ATOM 3931 CB GLN A 528 −73.424 13.157 −17.906 1.00 81.16 C ATOM 3932 CG GLN A 528 −73.022 14.260 −18.845 1.00 83.66 C ATOM 3933 CD GLN A 528 −73.742 14.149 −20.161 1.00 84.26 C ATOM 3934 OE1 GLN A 528 −74.663 13.359 −20.299 1.00 81.69 O ATOM 3935 NE2 GLN A 528 −73.322 14.933 −21.136 1.00 84.24 N ATOM 3936 C GLN A 528 −72.574 13.656 −15.660 1.00 78.71 C ATOM 3937 O GLN A 528 −73.458 13.403 −14.868 1.00 78.63 O ATOM 3938 N ILE A 529 −71.743 14.664 −15.486 1.00 75.06 N ATOM 3939 CA ILE A 529 −71.888 15.534 −14.341 1.00 72.22 C ATOM 3940 CB ILE A 529 −70.789 15.226 −13.309 1.00 71.75 C ATOM 3941 CG1 ILE A 529 −71.142 13.946 −12.571 1.00 69.44 C ATOM 3942 CD1 ILE A 529 −70.240 13.672 −11.395 1.00 66.78 C ATOM 3943 CG2 ILE A 529 −70.578 16.354 −12.311 1.00 68.83 C ATOM 3944 C ILE A 529 −71.947 17.003 −14.705 1.00 72.27 C ATOM 3945 O ILE A 529 −72.243 17.812 −13.863 1.00 75.52 O ATOM 3946 N SER A 530 −71.634 17.351 −15.936 1.00 75.46 N ATOM 3947 CA SER A 530 −71.648 18.744 −16.325 1.00 79.25 C ATOM 3948 CB SER A 530 −70.455 19.474 −15.736 1.00 79.31 C ATOM 3949 OG SER A 530 −70.307 19.128 −14.382 1.00 76.71 O ATOM 3950 C SER A 530 −71.608 18.895 −17.802 1.00 81.35 C ATOM 3951 O SER A 530 −71.375 17.953 −18.523 1.00 73.61 O ATOM 3952 N HIS A 531 −71.834 20.108 −18.247 1.00 90.67 N ATOM 3953 CA HIS A 531 −71.776 20.421 −19.648 1.00 99.36 C ATOM 3954 CB HIS A 531 −73.089 20.174 −20.370 1.00 104.70 C ATOM 3955 CG HIS A 531 −74.295 20.326 −19.506 1.00 115.45 C ATOM 3956 ND1 HIS A 531 −75.448 19.602 −19.712 1.00 119.07 N ATOM 3957 CE1 HIS A 531 −76.342 19.931 −18.797 1.00 115.77 C ATOM 3958 NE2 HIS A 531 −75.808 20.839 −18.002 1.00 118.22 N ATOM 3959 CD2 HIS A 531 −74.526 21.101 −18.421 1.00 119.98 C ATOM 3960 C HIS A 531 −71.464 21.864 −19.670 1.00 96.72 C ATOM 3961 O HIS A 531 −71.510 22.523 −18.651 1.00 97.53 O ATOM 3962 N THR A 532 −71.108 22.360 −20.829 1.00 94.34 N ATOM 3963 CA THR A 532 −70.811 23.760 −20.952 1.00 94.11 C ATOM 3964 CB THR A 532 −69.691 24.286 −20.024 1.00 90.97 C ATOM 3965 OG1 THR A 532 −68.782 25.114 −20.757 1.00 86.60 O ATOM 3966 CG2 THR A 532 −68.945 23.167 −19.377 1.00 92.91 C ATOM 3967 C THR A 532 −70.709 24.194 −22.379 1.00 94.12 C ATOM 3968 O THR A 532 −71.173 23.536 −23.287 1.00 96.05 O ATOM 3969 N GLU A 533 −70.120 25.352 −22.536 1.00 96.22 N ATOM 3970 CA GLU A 533 −69.992 26.002 −23.836 1.00 101.72 C ATOM 3971 CB GLU A 533 −71.238 26.889 −24.128 1.00 106.63 C ATOM 3972 CG GLU A 533 −72.475 26.196 −24.722 1.00 105.12 C ATOM 3973 CD GLU A 533 −72.361 25.890 −26.220 1.00 98.61 C ATOM 3974 OE1 GLU A 533 −71.351 25.276 −26.647 1.00 81.30 O ATOM 3975 OE2 GLU A 533 −73.302 26.263 −26.965 1.00 96.95 O ATOM 3976 C GLU A 533 −68.741 26.889 −23.717 1.00 93.80 C ATOM 3977 O GLU A 533 −68.402 27.308 −22.612 1.00 97.51 O ATOM 3978 N MET A 534 −68.054 27.187 −24.811 1.00 83.90 N ATOM 3979 CA MET A 534 −66.779 27.862 −24.668 1.00 83.99 C ATOM 3980 CB MET A 534 −65.642 26.808 −24.653 1.00 88.39 C ATOM 3981 CG MET A 534 −64.475 27.116 −23.685 1.00 89.35 C ATOM 3982 SD MET A 534 −64.648 26.901 −21.881 1.00 85.83 S ATOM 3983 CE MET A 534 −65.547 28.372 −21.302 1.00 86.18 C ATOM 3984 C MET A 534 −66.591 28.964 −25.713 1.00 79.95 C ATOM 3985 O MET A 534 −66.915 28.770 −26.897 1.00 73.23 O ATOM 3986 N GLU A 535 −66.066 30.112 −25.244 1.00 76.76 N ATOM 3987 CA GLU A 535 −66.003 31.369 −26.021 1.00 78.63 C ATOM 3988 CB GLU A 535 −65.556 32.535 −25.082 1.00 68.71 C ATOM 3989 C GLU A 535 −65.222 31.290 −27.417 1.00 84.80 C ATOM 3990 O GLU A 535 −65.338 32.161 −28.276 1.00 97.33 O ATOM 3991 N HIS A 536 −64.444 30.244 −27.645 1.00 90.14 N ATOM 3992 CA HIS A 536 −63.953 29.895 −28.988 1.00 90.06 C ATOM 3993 CB HIS A 536 −62.743 30.788 −29.361 1.00 85.40 C ATOM 3994 C HIS A 536 −63.695 28.330 −28.934 1.00 92.35 C ATOM 3995 O HIS A 536 −63.948 27.712 −27.869 1.00 88.42 O ATOM 3996 N GLU A 537 −63.270 27.679 −30.037 1.00 89.40 N ATOM 3997 CA GLU A 537 −63.163 26.163 −30.105 1.00 85.24 C ATOM 3998 CB GLU A 537 −63.026 25.629 −31.571 1.00 80.16 C ATOM 3999 C GLU A 537 −62.058 25.560 −29.190 1.00 78.72 C ATOM 4000 O GLU A 537 −60.950 26.092 −29.113 1.00 74.06 O ATOM 4001 N VAL A 538 −62.357 24.459 −28.493 1.00 72.56 N ATOM 4002 CA VAL A 538 −61.375 23.926 −27.504 1.00 74.64 C ATOM 4003 CB VAL A 538 −61.991 23.197 −26.252 1.00 70.25 C ATOM 4004 CG1 VAL A 538 −63.396 22.692 −26.507 1.00 75.32 C ATOM 4005 CG2 VAL A 538 −61.101 22.071 −25.744 1.00 66.57 C ATOM 4006 C VAL A 538 −60.165 23.193 −28.170 1.00 75.21 C ATOM 4007 O VAL A 538 −60.281 22.564 −29.224 1.00 72.34 O ATOM 4008 N ALA A 539 −59.001 23.364 −27.535 1.00 73.21 N ATOM 4009 CA ALA A 539 −57.718 22.924 −28.039 1.00 67.64 C ATOM 4010 CB ALA A 539 −56.799 24.113 −28.224 1.00 64.43 C ATOM 4011 C ALA A 539 −57.039 21.871 −27.152 1.00 69.55 C ATOM 4012 O ALA A 539 −56.440 20.942 −27.711 1.00 65.29 O ATOM 4013 N CYS A 540 −57.077 22.008 −25.816 1.00 67.53 N ATOM 4014 CA CYS A 540 −56.361 21.049 −24.959 1.00 70.33 C ATOM 4015 CB CYS A 540 −54.822 21.151 −25.109 1.00 74.53 C ATOM 4016 SG CYS A 540 −54.002 22.774 −25.150 1.00 71.22 S ATOM 4017 C CYS A 540 −56.718 21.084 −23.503 1.00 70.73 C ATOM 4018 O CYS A 540 −56.960 22.128 −22.968 1.00 75.29 O ATOM 4019 N LEU A 541 −56.700 19.920 −22.868 1.00 72.33 N ATOM 4020 CA LEU A 541 −57.218 19.766 −21.527 1.00 74.53 C ATOM 4021 CB LEU A 541 −58.459 18.908 −21.560 1.00 75.77 C ATOM 4022 CG LEU A 541 −59.541 19.406 −22.493 1.00 80.66 C ATOM 4023 CD1 LEU A 541 −60.625 18.360 −22.723 1.00 82.63 C ATOM 4024 CD2 LEU A 541 −60.114 20.682 −21.899 1.00 85.21 C ATOM 4025 C LEU A 541 −56.266 19.025 −20.669 1.00 78.38 C ATOM 4026 O LEU A 541 −55.592 18.141 −21.144 1.00 82.32 O ATOM 4027 N ASP A 542 −56.245 19.334 −19.386 1.00 85.01 N ATOM 4028 CA ASP A 542 −55.437 18.601 −18.438 1.00 86.67 C ATOM 4029 CB ASP A 542 −54.150 19.297 −18.064 1.00 88.02 C ATOM 4030 CG ASP A 542 −53.325 18.493 −17.092 1.00 89.90 C ATOM 4031 OD1 ASP A 542 −53.815 17.461 −16.607 1.00 94.22 O ATOM 4032 OD2 ASP A 542 −52.187 18.900 −16.798 1.00 85.56 O ATOM 4033 C ASP A 542 −56.337 18.435 −17.249 1.00 84.52 C ATOM 4034 O ASP A 542 −57.194 19.248 −17.018 1.00 78.18 O ATOM 4035 N ILE A 543 −56.182 17.351 −16.521 1.00 85.15 N ATOM 4036 CA ILE A 543 −57.045 17.093 −15.397 1.00 83.49 C ATOM 4037 CB ILE A 543 −58.194 16.223 −15.888 1.00 88.66 C ATOM 4038 CG1 ILE A 543 −59.332 16.202 −14.904 1.00 88.96 C ATOM 4039 CD1 ILE A 543 −60.436 17.133 −15.319 1.00 94.78 C ATOM 4040 CG2 ILE A 543 −57.713 14.825 −16.195 1.00 97.33 C ATOM 4041 C ILE A 543 −56.295 16.396 −14.278 1.00 81.04 C ATOM 4042 O ILE A 543 −56.872 15.670 −13.491 1.00 73.93 O ATOM 4043 N THR A 544 −54.994 16.595 −14.230 1.00 78.68 N ATOM 4044 CA THR A 544 −54.148 15.934 −13.256 1.00 77.99 C ATOM 4045 CB THR A 544 −52.710 16.326 −13.552 1.00 72.84 C ATOM 4046 OG1 THR A 544 −52.632 16.760 −14.905 1.00 68.65 O ATOM 4047 CG2 THR A 544 −51.818 15.178 −13.376 1.00 74.59 C ATOM 4048 C THR A 544 −54.365 16.226 −11.780 1.00 85.95 C ATOM 4049 O THR A 544 −54.514 17.363 −11.382 1.00 93.77 O ATOM 4050 N PRO A 545 −54.336 15.124 −10.937 1.00 88.26 N ATOM 4051 CA PRO A 545 −54.474 15.416 −9.506 1.00 94.04 C ATOM 4052 CB PRO A 545 −54.733 14.055 −8.885 1.00 97.73 C ATOM 4053 CG PRO A 545 −55.417 13.312 −9.949 1.00 97.95 C ATOM 4054 CD PRO A 545 −54.474 13.611 −11.054 1.00 92.21 C ATOM 4055 C PRO A 545 −53.214 16.046 −8.917 1.00 96.13 C ATOM 4056 O PRO A 545 −52.229 16.203 −9.611 1.00 100.02 O ATOM 4057 N LEU A 546 −53.271 16.452 −7.659 1.00 92.10 N ATOM 4058 CA LEU A 546 −52.190 17.205 −7.020 1.00 85.85 C ATOM 4059 CB LEU A 546 −52.073 18.526 −7.738 1.00 88.42 C ATOM 4060 CG LEU A 546 −51.693 18.519 −9.220 1.00 93.98 C ATOM 4061 CD1 LEU A 546 −52.117 19.829 −9.881 1.00 97.29 C ATOM 4062 CD2 LEU A 546 −50.193 18.274 −9.379 1.00 93.35 C ATOM 4063 C LEU A 546 −52.480 17.490 −5.538 1.00 80.95 C ATOM 4064 O LEU A 546 −52.045 16.768 −4.643 1.00 78.89 O ATOM 4065 N GLY A 551 −57.910 11.857 −3.782 1.00 83.35 N ATOM 4066 CA GLY A 551 −58.331 11.191 −5.047 1.00 91.36 C ATOM 4067 C GLY A 551 −58.537 12.034 −6.336 1.00 95.11 C ATOM 4068 O GLY A 551 −57.649 12.072 −7.202 1.00 87.97 O ATOM 4069 N LEU A 552 −59.710 12.694 −6.453 1.00 99.54 N ATOM 4070 CA LEU A 552 −60.202 13.423 −7.674 1.00 94.97 C ATOM 4071 CB LEU A 552 −61.740 13.281 −7.753 1.00 88.38 C ATOM 4072 C LEU A 552 −59.834 14.941 −7.786 1.00 93.26 C ATOM 4073 O LEU A 552 −60.056 15.707 −6.858 1.00 89.16 O ATOM 4074 N SER A 553 −59.313 15.378 −8.936 1.00 94.08 N ATOM 4075 CA SER A 553 −58.877 16.791 −9.125 1.00 95.98 C ATOM 4076 CB SER A 553 −58.193 17.015 −10.491 1.00 94.25 C ATOM 4077 OG SER A 553 −58.164 18.402 −10.891 1.00 88.59 O ATOM 4078 C SER A 553 −60.010 17.814 −9.037 1.00 100.53 C ATOM 4079 O SER A 553 −60.986 17.695 −9.772 1.00 98.88 O ATOM 4080 N PRO A 554 −59.831 18.883 −8.228 1.00 100.91 N ATOM 4081 CA PRO A 554 −60.939 19.808 −8.091 1.00 94.63 C ATOM 4082 CB PRO A 554 −60.584 20.560 −6.804 1.00 99.52 C ATOM 4083 CG PRO A 554 −59.104 20.340 −6.565 1.00 97.40 C ATOM 4084 CD PRO A 554 −58.594 19.455 −7.651 1.00 99.48 C ATOM 4085 C PRO A 554 −61.088 20.778 −9.270 1.00 89.51 C ATOM 4086 O PRO A 554 −62.033 21.550 −9.302 1.00 90.57 O ATOM 4087 N LEU A 555 −60.170 20.767 −10.226 1.00 87.98 N ATOM 4088 CA LEU A 555 −60.219 21.742 −11.320 1.00 89.57 C ATOM 4089 CB LEU A 555 −59.306 22.954 −11.001 1.00 89.70 C ATOM 4090 CG LEU A 555 −58.073 22.798 −10.114 1.00 87.15 C ATOM 4091 CD1 LEU A 555 −56.985 23.776 −10.531 1.00 84.19 C ATOM 4092 CD2 LEU A 555 −58.425 23.003 −8.642 1.00 86.44 C ATOM 4093 C LEU A 555 −59.945 21.045 −12.669 1.00 82.68 C ATOM 4094 O LEU A 555 −60.229 19.865 −12.792 1.00 78.44 O ATOM 4095 N CYS A 556 −59.463 21.779 −13.667 1.00 75.76 N ATOM 4096 CA CYS A 556 −59.342 21.302 −15.023 1.00 77.34 C ATOM 4097 CB CYS A 556 −60.737 20.929 −15.569 1.00 75.65 C ATOM 4098 SG CYS A 556 −60.781 20.832 −17.390 1.00 87.29 S ATOM 4099 C CYS A 556 −58.732 22.426 −15.887 1.00 75.45 C ATOM 4100 O CYS A 556 −59.401 23.434 −16.098 1.00 81.45 O ATOM 4101 N ALA A 557 −57.498 22.294 −16.380 1.00 70.56 N ATOM 4102 CA ALA A 557 −56.934 23.359 −17.250 1.00 69.83 C ATOM 4103 CB ALA A 557 −55.423 23.287 −17.324 1.00 71.05 C ATOM 4104 C ALA A 557 −57.528 23.254 −18.643 1.00 68.00 C ATOM 4105 O ALA A 557 −58.057 22.192 −18.980 1.00 63.23 O ATOM 4106 N ILE A 558 −57.491 24.372 −19.398 1.00 65.95 N ATOM 4107 CA ILE A 558 −57.899 24.440 −20.835 1.00 65.01 C ATOM 4108 CB ILE A 558 −59.276 25.059 −21.121 1.00 62.65 C ATOM 4109 CG1 ILE A 558 −60.228 24.895 −19.961 1.00 67.83 C ATOM 4110 CD1 ILE A 558 −60.848 23.513 −19.888 1.00 76.53 C ATOM 4111 CG2 ILE A 558 −59.843 24.486 −22.423 1.00 60.05 C ATOM 4112 C ILE A 558 −57.048 25.392 −21.634 1.00 64.48 C ATOM 4113 O ILE A 558 −56.569 26.373 −21.109 1.00 73.82 O ATOM 4114 N GLY A 559 −56.936 25.135 −22.922 1.00 61.01 N ATOM 4115 CA GLY A 559 −56.352 26.076 −23.859 1.00 63.23 C ATOM 4116 C GLY A 559 −57.360 26.139 −24.964 1.00 65.86 C ATOM 4117 O GLY A 559 −57.935 25.090 −25.270 1.00 67.90 O ATOM 4118 N LEU A 560 −57.584 27.332 −25.541 1.00 65.15 N ATOM 4119 CA LEU A 560 −58.646 27.546 −26.525 1.00 69.07 C ATOM 4120 CB LEU A 560 −59.781 28.336 −25.887 1.00 74.69 C ATOM 4121 CG LEU A 560 −60.429 27.663 −24.661 1.00 79.58 C ATOM 4122 CD1 LEU A 560 −61.505 28.541 −24.064 1.00 80.82 C ATOM 4123 CD2 LEU A 560 −61.070 26.309 −24.973 1.00 81.60 C ATOM 4124 C LEU A 560 −58.134 28.219 −27.794 1.00 74.07 C ATOM 4125 O LEU A 560 −57.008 28.733 −27.800 1.00 71.66 O ATOM 4126 N TRP A 561 −58.976 28.246 −28.844 1.00 79.75 N ATOM 4127 CA TRP A 561 −58.522 28.357 −30.274 1.00 84.58 C ATOM 4128 CB TRP A 561 −59.451 27.524 −31.196 1.00 84.52 C ATOM 4129 CG TRP A 561 −58.952 26.225 −31.773 1.00 80.02 C ATOM 4130 CD1 TRP A 561 −58.983 24.990 −31.189 1.00 78.08 C ATOM 4131 NE1 TRP A 561 −58.501 24.044 −32.061 1.00 77.84 N ATOM 4132 CE2 TRP A 561 −58.175 24.643 −33.250 1.00 78.57 C ATOM 4133 CD2 TRP A 561 −58.461 26.024 −33.114 1.00 83.29 C ATOM 4134 CE3 TRP A 561 −58.221 26.882 −34.214 1.00 83.04 C ATOM 4135 CZ3 TRP A 561 −57.693 26.325 −35.407 1.00 82.57 C ATOM 4136 CH2 TRP A 561 −57.407 24.942 −35.497 1.00 77.78 C ATOM 4137 CZ2 TRP A 561 −57.649 24.092 −34.442 1.00 75.47 C ATOM 4138 C TRP A 561 −58.423 29.753 −30.948 1.00 84.05 C ATOM 4139 O TRP A 561 −57.860 29.874 −32.048 1.00 84.26 O ATOM 4140 N THR A 562 −59.022 30.784 −30.392 1.00 78.71 N ATOM 4141 CA THR A 562 −58.959 32.041 −31.119 1.00 83.90 C ATOM 4142 CB THR A 562 −60.277 32.318 −31.830 1.00 92.62 C ATOM 4143 OG1 THR A 562 −60.896 31.065 −32.164 1.00 94.86 O ATOM 4144 CG2 THR A 562 −60.011 33.141 −33.104 1.00 93.87 C ATOM 4145 C THR A 562 −58.533 33.174 −30.237 1.00 83.39 C ATOM 4146 O THR A 562 −57.693 33.961 −30.660 1.00 77.29 O ATOM 4147 N ASP A 563 −59.090 33.233 −29.014 1.00 84.60 N ATOM 4148 CA ASP A 563 −58.484 33.944 −27.878 1.00 78.67 C ATOM 4149 CB ASP A 563 −59.354 33.809 −26.627 1.00 69.34 C ATOM 4150 C ASP A 563 −57.073 33.451 −27.530 1.00 85.33 C ATOM 4151 O ASP A 563 −56.477 34.024 −26.630 1.00 97.21 O ATOM 4152 N ILE A 564 −56.558 32.405 −28.219 1.00 89.15 N ATOM 4153 CA ILE A 564 −55.181 31.805 −28.068 1.00 87.66 C ATOM 4154 CB ILE A 564 −53.979 32.509 −28.859 1.00 92.84 C ATOM 4155 CG1 ILE A 564 −53.655 33.968 −28.309 1.00 103.14 C ATOM 4156 CD1 ILE A 564 −54.041 35.221 −29.109 1.00 101.41 C ATOM 4157 CG2 ILE A 564 −54.111 32.332 −30.379 1.00 84.93 C ATOM 4158 C ILE A 564 −54.790 31.676 −26.611 1.00 80.75 C ATOM 4159 O ILE A 564 −53.631 31.872 −26.263 1.00 77.19 O ATOM 4160 N SER A 565 −55.753 31.342 −25.764 1.00 75.59 N ATOM 4161 CA SER A 565 −55.577 31.574 −24.349 1.00 73.91 C ATOM 4162 CB SER A 565 −56.727 32.418 −23.895 1.00 76.73 C ATOM 4163 OG SER A 565 −57.350 31.783 −22.814 1.00 80.38 O ATOM 4164 C SER A 565 −55.521 30.331 −23.468 1.00 71.71 C ATOM 4165 O SER A 565 −56.281 29.398 −23.668 1.00 76.18 O ATOM 4166 N ALA A 566 −54.653 30.357 −22.460 1.00 70.25 N ATOM 4167 CA ALA A 566 −54.606 29.326 −21.394 1.00 66.33 C ATOM 4168 CB ALA A 566 −53.163 29.118 −20.916 1.00 59.68 C ATOM 4169 C ALA A 566 −55.546 29.737 −20.232 1.00 67.53 C ATOM 4170 O ALA A 566 −55.651 30.927 −19.938 1.00 64.30 O ATOM 4171 N ARG A 567 −56.252 28.773 −19.613 1.00 69.78 N ATOM 4172 CA ARG A 567 −57.326 29.051 −18.618 1.00 71.66 C ATOM 4173 CB ARG A 567 −58.693 29.277 −19.323 1.00 71.46 C ATOM 4174 CG ARG A 567 −58.782 30.336 −20.440 1.00 72.60 C ATOM 4175 CD ARG A 567 −60.096 30.239 −21.238 1.00 77.30 C ATOM 4176 NE ARG A 567 −60.624 31.455 −21.933 1.00 81.42 N ATOM 4177 CZ ARG A 567 −60.356 31.869 −23.195 1.00 85.92 C ATOM 4178 NH1 ARG A 567 −59.494 31.230 −24.003 1.00 88.70 N ATOM 4179 NH2 ARG A 567 −60.939 32.975 −23.663 1.00 85.51 N ATOM 4180 C ARG A 567 −57.491 27.891 −17.615 1.00 73.71 C ATOM 4181 O ARG A 567 −57.352 26.739 −18.017 1.00 78.32 O ATOM 4182 N ILE A 568 −57.799 28.191 −16.337 1.00 75.76 N ATOM 4183 CA ILE A 568 −58.241 27.170 −15.317 1.00 75.66 C ATOM 4184 CB ILE A 568 −57.692 27.426 −13.877 1.00 72.88 C ATOM 4185 CG1 ILE A 568 −56.227 27.935 −13.853 1.00 73.83 C ATOM 4186 CD1 ILE A 568 −55.221 27.143 −14.651 1.00 75.67 C ATOM 4187 CG2 ILE A 568 −57.957 26.219 −12.959 1.00 68.10 C ATOM 4188 C ILE A 568 −59.770 27.189 −15.128 1.00 79.27 C ATOM 4189 O ILE A 568 −60.382 28.247 −15.259 1.00 78.02 O ATOM 4190 N LEU A 569 −60.370 26.037 −14.788 1.00 82.66 N ATOM 4191 CA LEU A 569 −61.828 25.909 −14.461 1.00 83.01 C ATOM 4192 CB LEU A 569 −62.551 25.222 −15.623 1.00 82.57 C ATOM 4193 CG LEU A 569 −62.901 26.049 −16.869 1.00 84.29 C ATOM 4194 CD1 LEU A 569 −61.714 26.716 −17.543 1.00 82.49 C ATOM 4195 CD2 LEU A 569 −63.627 25.164 −17.886 1.00 88.04 C ATOM 4196 C LEU A 569 −62.046 25.141 −13.117 1.00 83.52 C ATOM 4197 O LEU A 569 −61.047 24.786 −12.479 1.00 81.48 O ATOM 4198 N LYS A 570 −63.279 24.903 −12.718 1.00 82.50 N ATOM 4199 CA LYS A 570 −63.523 24.201 −11.482 1.00 83.93 C ATOM 4200 CB LYS A 570 −64.198 25.114 −10.475 1.00 75.30 C ATOM 4201 C LYS A 570 −64.453 23.098 −11.837 1.00 85.29 C ATOM 4202 O LYS A 570 −65.173 23.202 −12.806 1.00 77.15 O ATOM 4203 N LEU A 571 −64.438 22.029 −11.070 1.00 91.16 N ATOM 4204 CA LEU A 571 −65.318 20.928 −11.355 1.00 88.31 C ATOM 4205 CB LEU A 571 −64.531 19.642 −11.534 1.00 82.26 C ATOM 4206 C LEU A 571 −66.168 20.847 −10.131 1.00 87.85 C ATOM 4207 O LEU A 571 −65.619 20.962 −9.049 1.00 91.10 O ATOM 4208 N PRO A 572 −67.550 20.685 −10.241 1.00 91.98 N ATOM 4209 CA PRO A 572 −68.115 20.544 −11.583 1.00 85.74 C ATOM 4210 CB PRO A 572 −69.292 19.586 −11.376 1.00 87.22 C ATOM 4211 CG PRO A 572 −69.404 19.333 −9.911 1.00 88.13 C ATOM 4212 CD PRO A 572 −68.732 20.496 −9.297 1.00 92.96 C ATOM 4213 C PRO A 572 −68.638 21.830 −12.149 1.00 83.16 C ATOM 4214 O PRO A 572 −69.404 21.784 −13.074 1.00 74.93 O ATOM 4215 N SER A 573 −68.292 22.958 −11.567 1.00 87.58 N ATOM 4216 CA SER A 573 −68.782 24.229 −12.069 1.00 90.79 C ATOM 4217 CB SER A 573 −68.418 25.347 −11.104 1.00 86.76 C ATOM 4218 OG SER A 573 −67.137 25.851 −11.394 1.00 82.72 O ATOM 4219 C SER A 573 −68.335 24.618 −13.473 1.00 92.86 C ATOM 4220 O SER A 573 −69.114 25.149 −14.235 1.00 91.68 O ATOM 4221 N PHE A 574 −67.085 24.352 −13.819 1.00 97.97 N ATOM 4222 CA PHE A 574 −66.555 24.764 −15.115 1.00 94.82 C ATOM 4223 C PHE A 574 −66.636 26.276 −15.147 1.00 98.01 C ATOM 4224 O PHE A 574 −67.016 26.870 −16.146 1.00 101.99 O ATOM 4225 CB PHE A 574 −67.337 24.139 −16.271 1.00 20.00 C ATOM 4226 N GLU A 575 −66.285 26.893 −14.024 1.00 97.59 N ATOM 4227 CA GLU A 575 −66.387 28.366 −13.859 1.00 88.91 C ATOM 4228 CB GLU A 575 −67.129 28.659 −12.553 1.00 87.72 C ATOM 4229 C GLU A 575 −64.996 29.038 −13.786 1.00 85.78 C ATOM 4230 O GLU A 575 −64.294 28.853 −12.765 1.00 85.97 O ATOM 4231 N LEU A 576 −64.643 29.844 −14.823 1.00 80.65 N ATOM 4232 CA LEU A 576 −63.291 30.521 −15.004 1.00 76.41 C ATOM 4233 CB LEU A 576 −63.330 31.661 −16.022 1.00 66.17 C ATOM 4234 C LEU A 576 −62.667 31.066 −13.727 1.00 78.85 C ATOM 4235 O LEU A 576 −63.367 31.681 −12.936 1.00 78.56 O ATOM 4236 N ALA A 577 −61.361 30.842 −13.539 1.00 81.22 N ATOM 4237 CA ALA A 577 −60.745 30.928 −12.202 1.00 81.36 C ATOM 4238 CB ALA A 577 −60.915 29.580 −11.444 1.00 70.61 C ATOM 4239 C ALA A 577 −59.270 31.510 −12.152 1.00 92.92 C ATOM 4240 O ALA A 577 −58.831 31.914 −11.069 1.00 102.01 O ATOM 4241 N HIS A 578 −58.682 31.599 −13.342 1.00 96.58 N ATOM 4242 CA HIS A 578 −57.438 32.257 −13.696 1.00 90.79 C ATOM 4243 CB HIS A 578 −56.227 31.453 −13.291 1.00 84.74 C ATOM 4244 C HIS A 578 −57.616 32.319 −15.209 1.00 84.02 C ATOM 4245 O HIS A 578 −58.299 31.472 −15.746 1.00 80.87 O ATOM 4246 N LYS A 579 −57.068 33.301 −15.904 1.00 77.60 N ATOM 4247 CA LYS A 579 −57.240 33.348 −17.354 1.00 84.58 C ATOM 4248 CB LYS A 579 −58.616 33.881 −17.685 1.00 90.36 C ATOM 4249 C LYS A 579 −56.228 34.219 −18.014 1.00 78.52 C ATOM 4250 O LYS A 579 −56.394 35.421 −17.957 1.00 68.13 O ATOM 4251 N GLU A 580 −55.210 33.667 −18.660 1.00 78.87 N ATOM 4252 CA GLU A 580 −54.216 34.536 −19.265 1.00 75.89 C ATOM 4253 CB GLU A 580 −52.840 34.341 −18.617 1.00 76.41 C ATOM 4254 CG GLU A 580 −51.770 35.192 −19.286 1.00 78.49 C ATOM 4255 CD GLU A 580 −50.528 35.397 −18.460 1.00 83.87 C ATOM 4256 OE1 GLU A 580 −49.458 35.653 −19.055 1.00 80.91 O ATOM 4257 OE2 GLU A 580 −50.629 35.307 −17.227 1.00 87.03 O ATOM 4258 C GLU A 580 −54.102 34.483 −20.760 1.00 72.40 C ATOM 4259 O GLU A 580 −53.973 33.433 −21.328 1.00 67.79 O ATOM 4260 N MET A 581 −54.144 35.644 −21.395 1.00 76.45 N ATOM 4261 CA MET A 581 −53.986 35.695 −22.825 1.00 75.16 C ATOM 4262 CB MET A 581 −54.392 37.031 −23.408 1.00 79.96 C ATOM 4263 CG MET A 581 −55.703 36.962 −24.160 1.00 80.54 C ATOM 4264 SD MET A 581 −56.888 35.944 −23.293 1.00 83.86 S ATOM 4265 CE MET A 581 −56.698 36.571 −21.645 1.00 83.07 C ATOM 4266 C MET A 581 −52.544 35.362 −23.064 1.00 70.68 C ATOM 4267 O MET A 581 −51.662 35.798 −22.359 1.00 64.20 O ATOM 4268 N LEU A 582 −52.338 34.577 −24.089 1.00 71.02 N ATOM 4269 CA LEU A 582 −51.055 33.976 −24.452 1.00 68.98 C ATOM 4270 CB LEU A 582 −51.288 32.489 −24.636 1.00 66.54 C ATOM 4271 CG LEU A 582 −50.383 31.550 −23.870 1.00 70.71 C ATOM 4272 CD1 LEU A 582 −50.269 31.938 −22.400 1.00 72.47 C ATOM 4273 CD2 LEU A 582 −50.890 30.114 −24.017 1.00 72.46 C ATOM 4274 C LEU A 582 −50.336 34.584 −25.672 1.00 70.13 C ATOM 4275 O LEU A 582 −49.128 34.337 −25.877 1.00 66.38 O ATOM 4276 N GLY A 583 −51.067 35.363 −26.472 1.00 72.07 N ATOM 4277 CA GLY A 583 −50.475 36.126 −27.554 1.00 75.16 C ATOM 4278 C GLY A 583 −50.377 35.386 −28.885 1.00 84.44 C ATOM 4279 O GLY A 583 −50.152 34.146 −28.940 1.00 91.81 O ATOM 4280 N GLY A 584 −50.574 36.159 −29.962 1.00 84.75 N ATOM 4281 CA GLY A 584 −50.143 35.786 −31.312 1.00 78.99 C ATOM 4282 C GLY A 584 −51.184 35.022 −32.076 1.00 77.06 C ATOM 4283 O GLY A 584 −52.328 34.916 −31.643 1.00 79.70 O ATOM 4284 N GLU A 585 −50.780 34.473 −33.212 1.00 76.14 N ATOM 4285 CA GLU A 585 −51.705 33.772 −34.079 1.00 76.89 C ATOM 4286 CB GLU A 585 −51.464 34.130 −35.548 1.00 77.79 C ATOM 4287 CG GLU A 585 −51.903 35.551 −35.884 1.00 80.77 C ATOM 4288 CD GLU A 585 −52.631 35.651 −37.205 1.00 87.60 C ATOM 4289 OE1 GLU A 585 −52.497 36.706 −37.856 1.00 90.71 O ATOM 4290 OE2 GLU A 585 −53.342 34.690 −37.596 1.00 89.17 O ATOM 4291 C GLU A 585 −51.722 32.271 −33.905 1.00 79.53 C ATOM 4292 O GLU A 585 −52.653 31.680 −34.407 1.00 85.34 O ATOM 4293 N ILE A 586 −50.756 31.645 −33.208 1.00 82.57 N ATOM 4294 CA ILE A 586 −50.739 30.156 −33.091 1.00 83.94 C ATOM 4295 CB ILE A 586 −49.330 29.536 −33.365 1.00 87.24 C ATOM 4296 CG1 ILE A 586 −48.735 30.050 −34.708 1.00 86.57 C ATOM 4297 CD1 ILE A 586 −47.540 30.966 −34.563 1.00 88.87 C ATOM 4298 CG2 ILE A 586 −49.415 28.009 −33.468 1.00 87.83 C ATOM 4299 C ILE A 586 −51.453 29.586 −31.813 1.00 79.71 C ATOM 4300 O ILE A 586 −51.366 30.141 −30.709 1.00 76.86 O ATOM 4301 N ILE A 587 −52.188 28.492 −32.035 1.00 73.27 N ATOM 4302 CA ILE A 587 −53.047 27.837 −31.040 1.00 75.80 C ATOM 4303 CB ILE A 587 −54.008 26.805 −31.710 1.00 79.93 C ATOM 4304 CG1 ILE A 587 −53.381 25.963 −32.860 1.00 87.16 C ATOM 4305 CD1 ILE A 587 −52.092 25.162 −32.602 1.00 92.94 C ATOM 4306 CG2 ILE A 587 −55.171 27.514 −32.344 1.00 82.76 C ATOM 4307 C ILE A 587 −52.264 27.089 −29.946 1.00 75.45 C ATOM 4308 O ILE A 587 −51.097 26.775 −30.142 1.00 78.56 O ATOM 4309 N PRO A 588 −52.885 26.807 −28.784 1.00 71.21 N ATOM 4310 CA PRO A 588 −52.353 25.770 −27.907 1.00 70.81 C ATOM 4311 CB PRO A 588 −53.351 25.792 −26.747 1.00 71.11 C ATOM 4312 CG PRO A 588 −53.544 27.247 −26.549 1.00 71.02 C ATOM 4313 CD PRO A 588 −53.566 27.827 −27.970 1.00 73.10 C ATOM 4314 C PRO A 588 −52.290 24.382 −28.519 1.00 67.03 C ATOM 4315 O PRO A 588 −53.172 24.056 −29.283 1.00 66.73 O ATOM 4316 N ARG A 589 −51.247 23.596 −28.191 1.00 66.36 N ATOM 4317 CA ARG A 589 −51.165 22.150 −28.554 1.00 64.13 C ATOM 4318 CB ARG A 589 −50.029 21.856 −29.577 1.00 59.62 C ATOM 4319 C ARG A 589 −51.193 21.175 −27.319 1.00 59.82 C ATOM 4320 O ARG A 589 −51.721 20.078 −27.416 1.00 61.58 O ATOM 4321 N SER A 590 −50.676 21.555 −26.167 1.00 57.95 N ATOM 4322 CA SER A 590 −50.838 20.723 −24.964 1.00 58.70 C ATOM 4323 CB SER A 590 −49.812 19.572 −24.824 1.00 56.64 C ATOM 4324 C SER A 590 −50.707 21.638 −23.786 1.00 61.70 C ATOM 4325 O SER A 590 −50.017 22.682 −23.833 1.00 56.13 O ATOM 4326 N ILE A 591 −51.385 21.224 −22.724 1.00 64.61 N ATOM 4327 CA ILE A 591 −51.420 21.982 −21.509 1.00 64.14 C ATOM 4328 CB ILE A 591 −52.713 22.786 −21.398 1.00 69.41 C ATOM 4329 CG1 ILE A 591 −52.518 23.858 −20.323 1.00 76.97 C ATOM 4330 CD1 ILE A 591 −53.498 24.997 −20.446 1.00 81.53 C ATOM 4331 CG2 ILE A 591 −53.959 21.896 −21.159 1.00 67.46 C ATOM 4332 C ILE A 591 −51.303 20.998 −20.408 1.00 60.79 C ATOM 4333 O ILE A 591 −51.825 19.930 −20.544 1.00 63.71 O ATOM 4334 N LEU A 592 −50.602 21.351 −19.346 1.00 62.09 N ATOM 4335 CA LEU A 592 −50.238 20.401 −18.303 1.00 68.64 C ATOM 4336 CB LEU A 592 −48.890 19.741 −18.638 1.00 66.48 C ATOM 4337 CG LEU A 592 −48.318 18.629 −17.708 1.00 68.09 C ATOM 4338 CD1 LEU A 592 −49.321 17.727 −16.966 1.00 64.40 C ATOM 4339 CD2 LEU A 592 −47.347 17.752 −18.493 1.00 69.87 C ATOM 4340 C LEU A 592 −50.166 21.078 −16.924 1.00 76.53 C ATOM 4341 O LEU A 592 −49.398 22.058 −16.748 1.00 76.84 O ATOM 4342 N MET A 593 −50.972 20.560 −15.975 1.00 75.46 N ATOM 4343 CA MET A 593 −50.955 20.987 −14.574 1.00 78.71 C ATOM 4344 CB MET A 593 −52.331 20.851 −13.889 1.00 83.10 C ATOM 4345 CG MET A 593 −53.175 22.114 −13.720 1.00 81.80 C ATOM 4346 SD MET A 593 −54.945 21.754 −13.498 1.00 83.56 S ATOM 4347 CE MET A 593 −54.943 20.453 −12.236 1.00 83.78 C ATOM 4348 C MET A 593 −50.037 19.991 −13.946 1.00 77.58 C ATOM 4349 O MET A 593 −50.370 18.797 −13.923 1.00 84.06 O ATOM 4350 N THR A 594 −48.905 20.464 −13.434 1.00 73.39 N ATOM 4351 CA THR A 594 −47.955 19.570 −12.816 1.00 73.95 C ATOM 4352 CB THR A 594 −46.867 19.188 −13.815 1.00 70.25 C ATOM 4353 OG1 THR A 594 −46.827 17.761 −13.895 1.00 71.88 O ATOM 4354 CG2 THR A 594 −45.472 19.764 −13.477 1.00 69.82 C ATOM 4355 C THR A 594 −47.405 20.111 −11.515 1.00 84.18 C ATOM 4356 O THR A 594 −47.607 21.283 −11.208 1.00 98.08 O ATOM 4357 N THR A 595 −46.657 19.289 −10.791 1.00 90.77 N ATOM 4358 CA THR A 595 −46.010 19.706 −9.551 1.00 86.88 C ATOM 4359 CB THR A 595 −46.707 19.105 −8.304 1.00 85.96 C ATOM 4360 OG1 THR A 595 −45.759 18.864 −7.265 1.00 80.22 O ATOM 4361 CG2 THR A 595 −47.386 17.813 −8.622 1.00 91.02 C ATOM 4362 C THR A 595 −44.507 19.402 −9.581 1.00 80.10 C ATOM 4363 O THR A 595 −44.111 18.270 −9.708 1.00 76.17 O ATOM 4364 N PHE A 596 −43.684 20.421 −9.417 1.00 82.51 N ATOM 4365 CA PHE A 596 −42.246 20.257 −9.418 1.00 89.45 C ATOM 4366 CB PHE A 596 −41.598 21.111 −10.477 1.00 93.61 C ATOM 4367 CG PHE A 596 −41.671 20.534 −11.848 1.00 96.20 C ATOM 4368 CD1 PHE A 596 −41.485 19.198 −12.052 1.00 93.56 C ATOM 4369 CE1 PHE A 596 −41.538 18.674 −13.313 1.00 93.45 C ATOM 4370 CZ PHE A 596 −41.768 19.489 −14.384 1.00 90.32 C ATOM 4371 CE2 PHE A 596 −41.952 20.826 −14.191 1.00 89.10 C ATOM 4372 CD2 PHE A 596 −41.896 21.343 −12.929 1.00 94.37 C ATOM 4373 C PHE A 596 −41.762 20.714 −8.075 1.00 95.95 C ATOM 4374 O PHE A 596 −42.361 21.582 −7.456 1.00 90.97 O ATOM 4375 N GLU A 597 −40.686 20.110 −7.573 1.00 103.55 N ATOM 4376 CA GLU A 597 −40.182 20.441 −6.244 1.00 105.68 C ATOM 4377 CB GLU A 597 −39.905 21.928 −6.168 1.00 108.45 C ATOM 4378 CG GLU A 597 −38.823 22.306 −5.186 1.00 107.72 C ATOM 4379 CD GLU A 597 −37.443 22.120 −5.758 1.00 103.22 C ATOM 4380 OE1 GLU A 597 −37.088 20.970 −6.043 1.00 103.58 O ATOM 4381 OE2 GLU A 597 −36.716 23.121 −5.913 1.00 99.39 O ATOM 4382 C GLU A 597 −41.358 20.062 −5.372 1.00 104.58 C ATOM 4383 O GLU A 597 −41.895 18.979 −5.546 1.00 108.63 O ATOM 4384 N SER A 598 −41.787 20.931 −4.483 1.00 98.35 N ATOM 4385 CA SER A 598 −42.986 20.647 −3.738 1.00 91.10 C ATOM 4386 CB SER A 598 −42.733 20.590 −2.259 1.00 88.33 C ATOM 4387 OG SER A 598 −43.490 19.530 −1.720 1.00 88.20 O ATOM 4388 C SER A 598 −44.049 21.667 −4.125 1.00 90.80 C ATOM 4389 O SER A 598 −45.065 21.786 −3.476 1.00 85.25 O ATOM 4390 N SER A 599 −43.785 22.403 −5.195 1.00 97.99 N ATOM 4391 CA SER A 599 −44.655 23.437 −5.712 1.00 95.92 C ATOM 4392 CB SER A 599 −43.809 24.480 −6.414 1.00 98.82 C ATOM 4393 OG SER A 599 −42.620 24.708 −5.689 1.00 99.77 O ATOM 4394 C SER A 599 −45.678 22.909 −6.685 1.00 88.97 C ATOM 4395 O SER A 599 −45.776 21.721 −6.895 1.00 77.01 O ATOM 4396 N HIS A 600 −46.467 23.817 −7.243 1.00 91.39 N ATOM 4397 CA HIS A 600 −47.469 23.487 −8.239 1.00 92.74 C ATOM 4398 CB HIS A 600 −48.851 23.602 −7.660 1.00 92.16 C ATOM 4399 CG HIS A 600 −49.126 22.604 −6.599 1.00 95.67 C ATOM 4400 ND1 HIS A 600 −48.280 21.551 −6.351 1.00 96.55 N ATOM 4401 CE1 HIS A 600 −48.774 20.822 −5.370 1.00 96.70 C ATOM 4402 NE2 HIS A 600 −49.909 21.366 −4.975 1.00 95.39 N ATOM 4403 CD2 HIS A 600 −50.155 22.479 −5.734 1.00 96.19 C ATOM 4404 C HIS A 600 −47.382 24.439 −9.399 1.00 95.63 C ATOM 4405 O HIS A 600 −47.393 25.641 −9.203 1.00 104.87 O ATOM 4406 N TYR A 601 −47.325 23.919 −10.613 1.00 95.55 N ATOM 4407 CA TYR A 601 −47.239 24.792 −11.764 1.00 90.47 C ATOM 4408 CB TYR A 601 −45.810 24.850 −12.300 1.00 87.84 C ATOM 4409 CG TYR A 601 −44.676 24.947 −11.309 1.00 89.85 C ATOM 4410 CD1 TYR A 601 −44.652 24.187 −10.161 1.00 93.09 C ATOM 4411 CE1 TYR A 601 −43.599 24.265 −9.276 1.00 97.48 C ATOM 4412 CZ TYR A 601 −42.532 25.084 −9.554 1.00 93.89 C ATOM 4413 OH TYR A 601 −41.474 25.160 −8.681 1.00 85.92 O ATOM 4414 CE2 TYR A 601 −42.521 25.831 −10.700 1.00 89.00 C ATOM 4415 CD2 TYR A 601 −43.586 25.753 −11.571 1.00 89.88 C ATOM 4416 C TYR A 601 −48.101 24.328 −12.913 1.00 86.12 C ATOM 4417 o TYR A 601 −48.481 23.177 −12.990 1.00 80.44 O ATOM 4418 N LEU A 602 −48.396 25.262 −13.803 1.00 85.06 N ATOM 4419 CA LEU A 602 −49.088 25.011 −15.068 1.00 75.71 C ATOM 4420 CB LEU A 602 −50.236 25.954 −15.236 1.00 71.78 C ATOM 4421 CG LEU A 602 −51.077 25.633 −16.460 1.00 75.58 C ATOM 4422 CD1 LEU A 602 −52.526 25.408 −16.046 1.00 77.66 C ATOM 4423 CD2 LEU A 602 −50.962 26.738 −17.500 1.00 74.25 C ATOM 4424 C LEU A 602 −48.129 25.263 −16.221 1.00 75.57 C ATOM 4425 O LEU A 602 −47.482 26.329 −16.296 1.00 68.67 O ATOM 4426 N LEU A 603 −48.030 24.267 −17.103 1.00 74.54 N ATOM 4427 CA LEU A 603 −47.282 24.400 −18.353 1.00 73.64 C ATOM 4428 CB LEU A 603 −46.253 23.262 −18.552 1.00 77.60 C ATOM 4429 CG LEU A 603 −44.964 23.179 −17.705 1.00 77.15 C ATOM 4430 CD1 LEU A 603 −45.291 23.112 −16.229 1.00 81.74 C ATOM 4431 CD2 LEU A 603 −44.144 21.962 −18.072 1.00 78.37 C ATOM 4432 C LEU A 603 −48.323 24.421 −19.464 1.00 68.16 C ATOM 4433 O LEU A 603 −49.419 23.886 −19.288 1.00 64.38 O ATOM 4434 N CYS A 604 −47.985 25.128 −20.546 1.00 67.04 N ATOM 4435 CA CYS A 604 −48.800 25.248 −21.746 1.00 64.89 C ATOM 4436 CB CYS A 604 −49.711 26.460 −21.695 1.00 63.06 C ATOM 4437 SG CYS A 604 −50.952 26.252 −22.989 1.00 69.00 S ATOM 4438 C CYS A 604 −47.900 25.397 −22.950 1.00 64.50 C ATOM 4439 O CYS A 604 −47.002 26.244 −22.922 1.00 64.70 O ATOM 4440 N ALA A 605 −48.135 24.590 −23.995 1.00 65.48 N ATOM 4441 CA ALA A 605 −47.300 24.623 −25.216 1.00 67.14 C ATOM 4442 CB ALA A 605 −46.682 23.263 −25.458 1.00 63.85 C ATOM 4443 C ALA A 605 −48.040 25.135 −26.484 1.00 70.72 C ATOM 4444 O ALA A 605 −49.210 24.807 −26.715 1.00 66.96 O ATOM 4445 N LEU A 606 −47.340 25.956 −27.273 1.00 74.10 N ATOM 4446 CA LEU A 606 −47.859 26.507 −28.523 1.00 77.22 C ATOM 4447 CB LEU A 606 −47.494 27.991 −28.689 1.00 77.73 C ATOM 4448 CG LEU A 606 −47.902 29.034 −27.624 1.00 81.91 C ATOM 4449 CD1 LEU A 606 −48.136 30.419 −28.250 1.00 80.03 C ATOM 4450 CD2 LEU A 606 −49.105 28.583 −26.777 1.00 81.52 C ATOM 4451 C LEU A 606 −47.281 25.737 −29.690 1.00 81.89 C ATOM 4452 O LEU A 606 −46.202 25.134 −29.570 1.00 88.20 O ATOM 4453 N GLY A 607 −48.004 25.781 −30.817 1.00 84.48 N ATOM 4454 CA GLY A 607 −47.640 25.103 −32.066 1.00 85.05 C ATOM 4455 C GLY A 607 −46.297 25.521 −32.646 1.00 88.67 C ATOM 4456 O GLY A 607 −45.571 24.686 −33.191 1.00 93.71 O ATOM 4457 N ASP A 608 −45.957 26.804 −32.512 1.00 88.05 N ATOM 4458 CA ASP A 608 −44.627 27.305 −32.897 1.00 87.10 C ATOM 4459 CB ASP A 608 −44.602 28.848 −32.960 1.00 90.29 C ATOM 4460 CG ASP A 608 −44.833 29.519 −31.593 1.00 89.69 C ATOM 4461 OD1 ASP A 608 −45.366 28.864 −30.675 1.00 84.75 O ATOM 4462 OD2 ASP A 608 −44.501 30.717 −31.452 1.00 93.34 O ATOM 4463 C ASP A 608 −43.443 26.827 −32.044 1.00 84.59 C ATOM 4464 O ASP A 608 −42.313 27.077 −32.444 1.00 90.74 O ATOM 4465 N GLY A 609 −43.672 26.189 −30.888 1.00 78.51 N ATOM 4466 CA GLY A 609 −42.564 25.804 −29.969 1.00 80.68 C ATOM 4467 C GLY A 609 −42.567 26.406 −28.553 1.00 77.60 C ATOM 4468 O GLY A 609 −42.107 25.785 −27.598 1.00 73.18 O ATOM 4469 N ALA A 610 −43.088 27.623 −28.437 1.00 79.21 N ATOM 4470 CA ALA A 610 −43.288 28.342 −27.163 1.00 74.27 C ATOM 4471 CB ALA A 610 −44.120 29.620 −27.410 1.00 74.04 C ATOM 4472 C ALA A 610 −43.905 27.523 −26.002 1.00 69.79 C ATOM 4473 O ALA A 610 −44.976 26.915 −26.104 1.00 60.94 O ATOM 4474 N LEU A 611 −43.198 27.544 −24.887 1.00 69.85 N ATOM 4475 CA LEU A 611 −43.663 26.931 −23.686 1.00 74.21 C ATOM 4476 CB LEU A 611 −42.676 25.842 −23.282 1.00 78.04 C ATOM 4477 CG LEU A 611 −43.001 24.857 −22.153 1.00 80.92 C ATOM 4478 CD1 LEU A 611 −42.269 25.246 −20.888 1.00 86.76 C ATOM 4479 CD2 LEU A 611 −44.481 24.747 −21.853 1.00 81.41 C ATOM 4480 C LEU A 611 −43.733 28.050 −22.667 1.00 76.73 C ATOM 4481 O LEU A 611 −42.730 28.750 −22.451 1.00 75.56 O ATOM 4482 N PHE A 612 −44.930 28.249 −22.106 1.00 77.44 N ATOM 4483 CA PHE A 612 −45.177 29.227 −21.045 1.00 80.41 C ATOM 4484 CB PHE A 612 −46.445 30.078 −21.313 1.00 85.15 C ATOM 4485 CG PHE A 612 −46.293 31.089 −22.431 1.00 87.90 C ATOM 4486 CD1 PHE A 612 −45.560 32.267 −22.238 1.00 87.59 C ATOM 4487 CE1 PHE A 612 −45.409 33.179 −23.269 1.00 85.72 C ATOM 4488 CZ PHE A 612 −45.992 32.932 −24.505 1.00 87.13 C ATOM 4489 CE2 PHE A 612 −46.711 31.768 −24.720 1.00 84.79 C ATOM 4490 CD2 PHE A 612 −46.871 30.861 −23.684 1.00 85.33 C ATOM 4491 C PHE A 612 −45.398 28.427 −19.774 1.00 79.86 C ATOM 4492 O PHE A 612 −46.193 27.483 −19.786 1.00 74.35 O ATOM 4493 N TYR A 613 −44.733 28.820 −18.682 1.00 77.95 N ATOM 4494 CA TYR A 613 −45.087 28.301 −17.358 1.00 75.32 C ATOM 4495 CB TYR A 613 −43.967 27.569 −16.770 1.00 71.71 C ATOM 4496 CG TYR A 613 −42.571 28.042 −16.711 1.00 67.52 C ATOM 4497 CD1 TYR A 613 −41.789 28.133 −17.858 1.00 65.63 C ATOM 4498 CE1 TYR A 613 −40.471 28.603 −17.801 1.00 65.27 C ATOM 4499 CZ TYR A 613 −39.907 28.980 −16.570 1.00 64.53 C ATOM 4500 OH TYR A 613 −38.606 29.461 −16.548 1.00 56.40 O ATOM 4501 CE2 TYR A 613 −40.663 28.865 −15.402 1.00 66.58 C ATOM 4502 CD2 TYR A 613 −41.977 28.385 −15.475 1.00 67.89 C ATOM 4503 C TYR A 613 −45.615 29.328 −16.330 1.00 78.43 C ATOM 4504 O TYR A 613 −45.327 30.527 −16.410 1.00 76.05 O ATOM 4505 N PHE A 614 −46.412 28.822 −15.386 1.00 78.40 N ATOM 4506 CA PHE A 614 −47.058 29.615 −14.341 1.00 83.02 C ATOM 4507 CB PHE A 614 −48.512 29.875 −14.742 1.00 87.38 C ATOM 4508 CG PHE A 614 −48.666 30.683 −15.998 1.00 91.32 C ATOM 4509 CD1 PHE A 614 −48.552 30.079 −17.260 1.00 91.87 C ATOM 4510 CE1 PHE A 614 −48.691 30.820 −18.428 1.00 88.66 C ATOM 4511 CZ PHE A 614 −48.949 32.181 −18.339 1.00 93.34 C ATOM 4512 CE2 PHE A 614 −49.066 32.795 −17.087 1.00 93.51 C ATOM 4513 CD2 PHE A 614 −48.930 32.046 −15.931 1.00 93.67 C ATOM 4514 C PHE A 614 −47.053 28.836 −13.006 1.00 85.77 C ATOM 4515 O PHE A 614 −47.275 27.628 −13.030 1.00 93.65 O ATOM 4516 N GLY A 615 −46.816 29.500 −11.858 1.00 77.80 N ATOM 4517 CA GLY A 615 −46.992 28.862 −10.534 1.00 72.98 C ATOM 4518 C GLY A 615 −48.473 28.605 −10.303 1.00 72.64 C ATOM 4519 O GLY A 615 −49.275 29.403 −10.728 1.00 73.28 O ATOM 4520 N LEU A 616 −48.864 27.518 −9.648 1.00 72.56 N ATOM 4521 CA LEU A 616 −50.285 27.218 −9.508 1.00 80.57 C ATOM 4522 CB LEU A 616 −50.632 25.891 −10.169 1.00 87.89 C ATOM 4523 CG LEU A 616 −52.141 25.597 −10.371 1.00 95.58 C ATOM 4524 CD1 LEU A 616 −52.732 26.481 −11.467 1.00 100.27 C ATOM 4525 CD2 LEU A 616 −52.439 24.136 −10.670 1.00 98.76 C ATOM 4526 C LEU A 616 −50.758 27.184 −8.074 1.00 87.84 C ATOM 4527 O LEU A 616 −50.027 26.827 −7.164 1.00 96.81 O ATOM 4528 N ASN A 617 −51.979 27.626 −7.868 1.00 94.21 N ATOM 4529 CA ASN A 617 −52.535 27.627 −6.546 1.00 98.71 C ATOM 4530 CB ASN A 617 −53.035 29.019 −6.226 1.00 99.72 C ATOM 4531 CG ASN A 617 −53.683 29.099 −4.878 1.00 101.08 C ATOM 4532 OD1 ASN A 617 −53.343 29.953 −4.075 1.00 108.72 O ATOM 4533 ND2 ASN A 617 −54.613 28.200 −4.613 1.00 101.68 N ATOM 4534 C ASN A 617 −53.687 26.696 −6.688 1.00 101.16 C ATOM 4535 O ASN A 617 −54.709 27.079 −7.229 1.00 102.17 O ATOM 4536 N ILE A 618 −53.552 25.481 −6.185 1.00 99.91 N ATOM 4537 CA ILE A 618 −54.619 24.528 −6.360 1.00 102.01 C ATOM 4538 CB ILE A 618 −54.253 23.136 −5.833 1.00 100.01 C ATOM 4539 CG1 ILE A 618 −54.255 23.101 −4.313 1.00 100.40 C ATOM 4540 CD1 ILE A 618 −53.959 21.731 −3.748 1.00 93.86 C ATOM 4541 CG2 ILE A 618 −52.895 22.726 −6.344 1.00 100.40 C ATOM 4542 C ILE A 618 −55.911 24.946 −5.723 1.00 111.07 C ATOM 4543 O ILE A 618 −56.959 24.800 −6.326 1.00 120.34 O ATOM 4544 N GLU A 619 −55.855 25.469 −4.510 1.00 106.01 N ATOM 4545 CA GLU A 619 −57.085 25.839 −3.838 1.00 96.25 C ATOM 4546 CB GLU A 619 −56.776 26.257 −2.410 1.00 96.37 C ATOM 4547 C GLU A 619 −57.870 26.933 −4.524 1.00 88.63 C ATOM 4548 O GLU A 619 −59.071 26.835 −4.672 1.00 71.44 O ATOM 4549 N THR A 620 −57.181 27.973 −4.951 1.00 90.41 N ATOM 4550 CA THR A 620 −57.830 29.100 −5.583 1.00 90.17 C ATOM 4551 CB THR A 620 −57.148 30.393 −5.142 1.00 81.28 C ATOM 4552 C THR A 620 −57.826 29.144 −7.091 1.00 95.63 C ATOM 4553 O THR A 620 −58.811 29.494 −7.713 1.00 96.18 O ATOM 4554 N GLY A 621 −56.699 28.802 −7.674 1.00 97.39 N ATOM 4555 CA GLY A 621 −56.513 28.862 −9.137 1.00 96.30 C ATOM 4556 C GLY A 621 −55.500 29.910 −9.617 1.00 99.98 C ATOM 4557 O GLY A 621 −55.190 29.970 −10.816 1.00 94.56 O ATOM 4558 N LEU A 622 −54.994 30.748 −8.703 1.00 105.31 N ATOM 4559 CA LEU A 622 −54.068 31.829 −9.069 1.00 103.24 C ATOM 4560 CB LEU A 622 −53.759 32.756 −7.858 1.00 98.15 C ATOM 4561 C LEU A 622 −52.796 31.288 −9.802 1.00 95.15 C ATOM 4562 O LEU A 622 −51.860 30.718 −9.211 1.00 80.42 O ATOM 4563 N LEU A 623 −52.845 31.430 −11.127 1.00 95.50 N ATOM 4564 CA LEU A 623 −51.662 31.342 −11.987 1.00 96.38 C ATOM 4565 CB LEU A 623 −52.046 31.041 −13.475 1.00 97.26 C ATOM 4566 C LEU A 623 −50.835 32.649 −11.808 1.00 86.10 C ATOM 4567 O LEU A 623 −51.360 33.744 −11.970 1.00 77.35 O ATOM 4568 N SER A 624 −49.555 32.494 −11.449 1.00 83.18 N ATOM 4569 CA SER A 624 −48.604 33.593 −11.186 1.00 79.78 C ATOM 4570 CB SER A 624 −48.312 33.632 −9.672 1.00 78.15 C ATOM 4571 OG SER A 624 −47.345 32.661 −9.265 1.00 73.43 O ATOM 4572 C SER A 624 −47.264 33.472 −11.980 1.00 78.93 C ATOM 4573 O SER A 624 −46.916 32.400 −12.449 1.00 83.33 O ATOM 4574 N ASP A 625 −46.525 34.573 −12.109 1.00 80.84 N ATOM 4575 CA ASP A 625 −45.152 34.608 −12.676 1.00 84.69 C ATOM 4576 CB ASP A 625 −44.147 34.038 −11.680 1.00 90.68 C ATOM 4577 CG ASP A 625 −43.978 34.907 −10.477 1.00 99.65 C ATOM 4578 OD1 ASP A 625 −43.917 36.149 −10.633 1.00 104.12 O ATOM 4579 OD2 ASP A 625 −43.890 34.346 −9.368 1.00 111.73 O ATOM 4580 C ASP A 625 −44.949 33.932 −14.026 1.00 84.04 C ATOM 4581 O ASP A 625 −44.254 32.899 −14.136 1.00 91.01 O ATOM 4582 N ARG A 626 −45.535 34.530 −15.058 1.00 77.22 N ATOM 4583 CA ARG A 626 −45.403 33.996 −16.399 1.00 72.04 C ATOM 4584 CB ARG A 626 −46.370 34.685 −17.396 1.00 73.60 C ATOM 4585 CG ARG A 626 −45.884 35.880 −18.263 1.00 74.29 C ATOM 4586 CD ARG A 626 −45.643 35.520 −19.749 1.00 70.04 C ATOM 4587 NE ARG A 626 −46.680 35.840 −20.766 1.00 66.20 N ATOM 4588 CZ ARG A 626 −48.028 35.823 −20.642 1.00 66.81 C ATOM 4589 NH1 ARG A 626 −48.684 35.526 −19.511 1.00 65.58 N ATOM 4590 NH2 ARG A 626 −48.776 36.109 −21.715 1.00 64.54 N ATOM 4591 C ARG A 626 −43.931 34.089 −16.785 1.00 68.01 C ATOM 4592 O ARG A 626 −43.288 35.096 −16.529 1.00 64.31 O ATOM 4593 N LYS A 627 −43.378 32.986 −17.270 1.00 65.55 N ATOM 4594 CA LYS A 627 −42.154 33.045 −18.042 1.00 65.20 C ATOM 4595 CB LYS A 627 −40.944 32.609 −17.193 1.00 61.46 C ATOM 4596 C LYS A 627 −42.380 32.236 −19.353 1.00 67.19 C ATOM 4597 O LYS A 627 −43.321 31.424 −19.473 1.00 62.01 O ATOM 4598 N LYS A 628 −41.555 32.539 −20.352 1.00 70.75 N ATOM 4599 CA LYS A 628 −41.614 31.914 −21.668 1.00 74.16 C ATOM 4600 CB LYS A 628 −41.841 32.972 −22.755 1.00 77.10 C ATOM 4601 CG LYS A 628 −41.678 32.487 −24.195 1.00 79.09 C ATOM 4602 CD LYS A 628 −42.371 33.400 −25.193 1.00 81.97 C ATOM 4603 CE LYS A 628 −41.798 33.218 −26.590 1.00 85.22 C ATOM 4604 NZ LYS A 628 −42.596 33.973 −27.583 1.00 87.33 N ATOM 4605 C LYS A 628 −40.298 31.266 −21.949 1.00 73.77 C ATOM 4606 O LYS A 628 −39.283 31.703 −21.454 1.00 73.86 O ATOM 4607 N VAL A 629 −40.324 30.307 −22.850 1.00 76.66 N ATOM 4608 CA VAL A 629 −39.127 29.694 −23.342 1.00 78.17 C ATOM 4609 CB VAL A 629 −38.648 28.582 −22.445 1.00 82.90 C ATOM 4610 CG1 VAL A 629 −39.726 27.536 −22.325 1.00 84.33 C ATOM 4611 CG2 VAL A 629 −37.387 27.991 −23.022 1.00 88.27 C ATOM 4612 C VAL A 629 −39.535 29.141 −24.678 1.00 75.87 C ATOM 4613 O VAL A 629 −40.698 28.849 −24.872 1.00 75.54 O ATOM 4614 N THR A 630 −38.599 28.985 −25.596 1.00 74.24 N ATOM 4615 CA THR A 630 −38.951 28.458 −26.894 1.00 78.00 C ATOM 4616 CB THR A 630 −38.677 29.486 −28.003 1.00 80.70 C ATOM 4617 OG1 THR A 630 −37.313 29.413 −28.416 1.00 81.31 O ATOM 4618 CG2 THR A 630 −38.950 30.885 −27.515 1.00 81.59 C ATOM 4619 C THR A 630 −38.175 27.187 −27.159 1.00 79.08 C ATOM 4620 O THR A 630 −36.963 27.197 −27.146 1.00 74.30 O ATOM 4621 N LEU A 631 −38.873 26.092 −27.406 1.00 81.37 N ATOM 4622 CA LEU A 631 −38.206 24.834 −27.660 1.00 81.88 C ATOM 4623 CB LEU A 631 −38.477 23.907 −26.489 1.00 81.85 C ATOM 4624 CG LEU A 631 −39.039 24.498 −25.206 1.00 80.43 C ATOM 4625 CD1 LEU A 631 −39.807 23.471 −24.407 1.00 73.92 C ATOM 4626 CD2 LEU A 631 −37.929 25.108 −24.386 1.00 79.49 C ATOM 4627 C LEU A 631 −38.764 24.117 −28.849 1.00 87.41 C ATOM 4628 O LEU A 631 −39.914 23.768 −28.817 1.00 99.19 O ATOM 4629 N GLY A 632 −37.974 23.833 −29.871 1.00 92.91 N ATOM 4630 CA GLY A 632 −38.486 23.075 −31.002 1.00 102.38 C ATOM 4631 C GLY A 632 −39.657 23.691 −31.721 1.00 105.65 C ATOM 4632 O GLY A 632 −40.764 23.680 −31.213 1.00 110.59 O ATOM 4633 N THR A 633 −39.437 24.201 −32.920 1.00 102.36 N ATOM 4634 CA THR A 633 −40.517 24.860 −33.629 1.00 100.41 C ATOM 4635 CB THR A 633 −40.037 25.443 −34.947 1.00 100.29 C ATOM 4636 OG1 THR A 633 −39.939 24.394 −35.902 1.00 95.66 O ATOM 4637 CG2 THR A 633 −38.688 26.063 −34.767 1.00 100.19 C ATOM 4638 C THR A 633 −41.727 23.985 −33.896 1.00 91.79 C ATOM 4639 O THR A 633 −42.839 24.453 −33.751 1.00 82.22 O ATOM 4640 N GLN A 634 −41.565 22.729 −34.273 1.00 88.95 N ATOM 4641 CA GLN A 634 −42.818 21.972 −34.502 1.00 86.91 C ATOM 4642 CB GLN A 634 −42.530 20.553 −35.062 1.00 77.10 C ATOM 4643 C GLN A 634 −43.679 22.042 −33.154 1.00 85.93 C ATOM 4644 O GLN A 634 −43.178 22.440 −32.096 1.00 78.31 O ATOM 4645 N PRO A 635 −44.998 21.751 −33.197 1.00 87.23 N ATOM 4646 CA PRO A 635 −45.805 21.825 −31.952 1.00 83.93 C ATOM 4647 CB PRO A 635 −47.216 21.416 −32.405 1.00 87.39 C ATOM 4648 CG PRO A 635 −47.241 21.677 −33.871 1.00 90.23 C ATOM 4649 CD PRO A 635 −45.833 21.469 −34.377 1.00 89.86 C ATOM 4650 C PRO A 635 −45.327 20.852 −30.900 1.00 81.61 C ATOM 4651 O PRO A 635 −44.676 19.867 −31.252 1.00 79.88 O ATOM 4652 N THR A 636 −45.701 21.089 −29.641 1.00 78.27 N ATOM 4653 CA THR A 636 −45.052 20.426 −28.494 1.00 77.77 C ATOM 4654 CB THR A 636 −44.139 21.445 −27.746 1.00 81.54 C ATOM 4655 OG1 THR A 636 −43.281 22.108 −28.694 1.00 89.80 O ATOM 4656 CG2 THR A 636 −43.263 20.779 −26.642 1.00 80.08 C ATOM 4657 C THR A 636 −46.011 19.731 −27.502 1.00 73.89 C ATOM 4658 O THR A 636 −46.723 20.412 −26.771 1.00 72.56 O ATOM 4659 N VAL A 637 −45.981 18.383 −27.456 1.00 71.24 N ATOM 4660 CA VAL A 637 −46.789 17.569 −26.511 1.00 68.23 C ATOM 4661 CB VAL A 637 −47.130 16.178 −27.083 1.00 69.43 C ATOM 4662 CG1 VAL A 637 −48.055 15.390 −26.133 1.00 69.62 C ATOM 4663 CG2 VAL A 637 −47.749 16.324 −28.465 1.00 71.51 C ATOM 4664 C VAL A 637 −46.061 17.335 −25.194 1.00 63.81 C ATOM 4665 O VAL A 637 −44.929 16.865 −25.205 1.00 60.73 O ATOM 4666 N LEU A 638 −46.740 17.610 −24.075 1.00 60.89 N ATOM 4667 CA LEU A 638 −46.152 17.465 −22.742 1.00 59.71 C ATOM 4668 CB LEU A 638 −46.375 18.722 −21.950 1.00 59.60 C ATOM 4669 CG LEU A 638 −45.764 20.016 −22.491 1.00 57.33 C ATOM 4670 CD1 LEU A 638 −46.479 21.215 −21.899 1.00 55.72 C ATOM 4671 CD2 LEU A 638 −44.297 20.091 −22.161 1.00 56.90 C ATOM 4672 C LEU A 638 −46.715 16.285 −21.976 1.00 60.73 C ATOM 4673 O LEU A 638 −47.853 15.955 −22.110 1.00 62.11 O ATOM 4674 N ARG A 639 −45.893 15.670 −21.145 1.00 67.47 N ATOM 4675 CA ARG A 639 −46.136 14.309 −20.667 1.00 68.68 C ATOM 4676 CB ARG A 639 −45.790 13.334 −21.776 1.00 75.83 C ATOM 4677 CG ARG A 639 −47.002 12.935 −22.604 1.00 87.96 C ATOM 4678 CD ARG A 639 −47.632 11.594 −22.181 1.00 93.91 C ATOM 4679 NE ARG A 639 −47.467 11.186 −20.770 1.00 94.83 N ATOM 4680 CZ ARG A 639 −48.019 10.090 −20.225 1.00 94.26 C ATOM 4681 NH1 ARG A 639 −48.800 9.244 −20.956 1.00 89.24 N ATOM 4682 NH2 ARG A 639 −47.802 9.851 −18.919 1.00 89.67 N ATOM 4683 C ARG A 639 −45.325 13.987 −19.424 1.00 64.92 C ATOM 4684 O ARG A 639 −44.114 14.218 −19.355 1.00 63.69 O ATOM 4685 N THR A 640 −46.002 13.465 −18.427 1.00 59.81 N ATOM 4686 CA THR A 640 −45.397 13.342 −17.139 1.00 58.63 C ATOM 4687 CB THR A 640 −46.495 13.549 −16.073 1.00 60.33 C ATOM 4688 OG1 THR A 640 −46.767 14.962 −15.963 1.00 59.03 O ATOM 4689 CG2 THR A 640 −46.131 12.913 −14.680 1.00 60.38 C ATOM 4690 C THR A 640 −44.734 11.973 −17.076 1.00 58.28 C ATOM 4691 O THR A 640 −45.285 11.024 −17.614 1.00 55.87 O ATOM 4692 N PHE A 641 −43.545 11.906 −16.455 1.00 59.93 N ATOM 4693 CA PHE A 641 −42.906 10.651 −15.963 1.00 61.58 C ATOM 4694 CB PHE A 641 −41.867 10.124 −16.976 1.00 61.81 C ATOM 4695 CG PHE A 641 −40.620 10.996 −17.209 1.00 54.54 C ATOM 4696 CD1 PHE A 641 −40.680 12.200 −17.873 1.00 56.26 C ATOM 4697 CE1 PHE A 641 −39.533 12.934 −18.147 1.00 54.94 C ATOM 4698 CZ PHE A 641 −38.306 12.441 −17.807 1.00 52.27 C ATOM 4699 CE2 PHE A 641 −38.237 11.230 −17.204 1.00 52.49 C ATOM 4700 CD2 PHE A 641 −39.384 10.514 −16.919 1.00 51.85 C ATOM 4701 C PHE A 641 −42.241 10.745 −14.575 1.00 68.80 C ATOM 4702 O PHE A 641 −41.992 11.849 −14.107 1.00 65.95 O ATOM 4703 N ARG A 642 −41.922 9.601 −13.944 1.00 77.35 N ATOM 4704 CA ARG A 642 −41.061 9.578 −12.712 1.00 82.93 C ATOM 4705 CB ARG A 642 −41.518 8.488 −11.730 1.00 89.57 C ATOM 4706 CG ARG A 642 −43.029 8.216 −11.694 1.00 100.96 C ATOM 4707 CD ARG A 642 −43.614 8.130 −10.284 1.00 108.08 C ATOM 4708 NE ARG A 642 −43.380 9.384 −9.549 1.00 119.92 N ATOM 4709 CZ ARG A 642 −44.079 9.817 −8.500 1.00 123.09 C ATOM 4710 NH1 ARG A 642 −45.118 9.125 −8.025 1.00 123.32 N ATOM 4711 NH2 ARG A 642 −43.737 10.978 −7.927 1.00 124.59 N ATOM 4712 C ARG A 642 −39.571 9.330 −13.061 1.00 85.76 C ATOM 4713 O ARG A 642 −39.306 8.477 −13.897 1.00 89.89 O ATOM 4714 N SER A 643 −38.608 10.047 −12.450 1.00 90.79 N ATOM 4715 CA SER A 643 −37.142 9.703 −12.562 1.00 96.55 C ATOM 4716 CB SER A 643 −36.386 10.564 −13.609 1.00 87.90 C ATOM 4717 C SER A 643 −36.410 9.776 −11.205 1.00 101.55 C ATOM 4718 O SER A 643 −35.829 10.822 −10.885 1.00 110.05 O ATOM 4719 N LEU A 644 −36.411 8.655 −10.454 1.00 95.96 N ATOM 4720 CA LEU A 644 −35.899 8.571 −9.055 1.00 95.11 C ATOM 4721 CB LEU A 644 −34.404 8.996 −8.918 1.00 80.47 C ATOM 4722 C LEU A 644 −36.815 9.321 −8.040 1.00 97.62 C ATOM 4723 O LEU A 644 −36.498 10.439 −7.616 1.00 95.22 O ATOM 4724 N SER A 645 −37.935 8.668 −7.669 1.00 100.62 N ATOM 4725 CA SER A 645 −38.939 9.111 −6.629 1.00 103.52 C ATOM 4726 CB SER A 645 −38.487 8.756 −5.187 1.00 99.83 C ATOM 4727 C SER A 645 −39.381 10.577 −6.706 1.00 103.29 C ATOM 4728 O SER A 645 −39.641 11.214 −5.690 1.00 101.72 O ATOM 4729 N THR A 646 −39.496 11.071 −7.933 1.00 108.06 N ATOM 4730 CA THR A 646 −39.762 12.484 −8.240 1.00 108.07 C ATOM 4731 CB THR A 646 −38.483 13.366 −8.052 1.00 110.10 C ATOM 4732 OG1 THR A 646 −38.791 14.743 −8.313 1.00 110.13 O ATOM 4733 CG2 THR A 646 −37.306 12.936 −8.967 1.00 106.37 C ATOM 4734 C THR A 646 −40.257 12.549 −9.696 1.00 103.93 C ATOM 4735 O THR A 646 −39.874 11.692 −10.498 1.00 110.41 O ATOM 4736 N THR A 647 −41.094 13.536 −10.037 1.00 94.13 N ATOM 4737 CA THR A 647 −41.638 13.661 −11.409 1.00 83.28 C ATOM 4738 CB THR A 647 −43.157 14.005 −11.461 1.00 83.97 C ATOM 4739 OG1 THR A 647 −43.364 15.423 −11.299 1.00 81.66 O ATOM 4740 CG2 THR A 647 −43.973 13.191 −10.435 1.00 82.28 C ATOM 4741 C THR A 647 −40.934 14.708 −12.263 1.00 73.49 C ATOM 4742 O THR A 647 −40.680 15.799 −11.815 1.00 69.72 O ATOM 4743 N ASN A 648 −40.663 14.353 −13.508 1.00 71.47 N ATOM 4744 CA ASN A 648 −40.339 15.300 −14.575 1.00 71.46 C ATOM 4745 CB ASN A 648 −39.061 14.867 −15.234 1.00 71.58 C ATOM 4746 CG ASN A 648 −37.958 14.804 −14.255 1.00 75.71 C ATOM 4747 OD1 ASN A 648 −38.078 15.393 −13.182 1.00 71.47 O ATOM 4748 ND2 ASN A 648 −36.871 14.101 −14.597 1.00 82.33 N ATOM 4749 C ASN A 648 −41.423 15.397 −15.626 1.00 70.40 C ATOM 4750 O ASN A 648 −42.478 14.746 −15.524 1.00 75.87 O ATOM 4751 N VAL A 649 −41.170 16.250 −16.611 1.00 63.36 N ATOM 4752 CA VAL A 649 −42.035 16.399 −17.744 1.00 59.26 C ATOM 4753 CB VAL A 649 −42.617 17.798 −17.791 1.00 55.44 C ATOM 4754 CG1 VAL A 649 −42.896 18.249 −19.208 1.00 56.43 C ATOM 4755 CG2 VAL A 649 −43.884 17.841 −16.967 1.00 56.33 C ATOM 4756 C VAL A 649 −41.175 16.148 −18.932 1.00 61.23 C ATOM 4757 O VAL A 649 −40.018 16.581 −18.964 1.00 67.34 O ATOM 4758 N PHE A 650 −41.734 15.437 −19.899 1.00 58.26 N ATOM 4759 CA PHE A 650 −41.043 15.184 −21.134 1.00 57.22 C ATOM 4760 CB PHE A 650 −41.090 13.696 −21.490 1.00 56.08 C ATOM 4761 CG PHE A 650 −40.182 13.333 −22.629 1.00 56.36 C ATOM 4762 CD1 PHE A 650 −40.571 13.551 −23.934 1.00 58.58 C ATOM 4763 CE1 PHE A 650 −39.734 13.209 −24.988 1.00 62.13 C ATOM 4764 CZ PHE A 650 −38.482 12.698 −24.737 1.00 59.65 C ATOM 4765 CE2 PHE A 650 −38.081 12.523 −23.427 1.00 57.47 C ATOM 4766 CD2 PHE A 650 −38.924 12.830 −22.393 1.00 54.69 C ATOM 4767 C PHE A 650 −41.741 15.988 −22.191 1.00 53.82 C ATOM 4768 O PHE A 650 −42.935 15.856 −22.344 1.00 55.52 O ATOM 4769 N ALA A 651 −41.010 16.789 −22.941 1.00 49.79 N ATOM 4770 CA ALA A 651 −41.641 17.642 −23.906 1.00 49.04 C ATOM 4771 CB ALA A 651 −41.147 19.060 −23.739 1.00 47.77 C ATOM 4772 C ALA A 651 −41.286 17.098 −25.238 1.00 49.06 C ATOM 4773 O ALA A 651 −40.189 17.301 −25.694 1.00 50.26 O ATOM 4774 N CYS A 652 −42.205 16.374 −25.852 1.00 53.14 N ATOM 4775 CA CYS A 652 −41.965 15.770 −27.185 1.00 56.51 C ATOM 4776 CB CYS A 652 −42.971 14.634 −27.480 1.00 56.00 C ATOM 4777 SG CYS A 652 −43.349 13.555 −26.072 1.00 56.84 S ATOM 4778 C CYS A 652 −42.046 16.845 −28.255 1.00 58.19 C ATOM 4779 O CYS A 652 −43.034 17.514 −28.338 1.00 54.03 O ATOM 4780 N SER A 653 −41.001 17.015 −29.063 1.00 71.35 N ATOM 4781 CA SER A 653 −40.949 18.078 −30.113 1.00 80.73 C ATOM 4782 CB SER A 653 −40.756 19.506 −29.489 1.00 88.29 C ATOM 4783 OG SER A 653 −39.406 19.869 −29.158 1.00 88.07 O ATOM 4784 C SER A 653 −39.868 17.793 −31.168 1.00 84.73 C ATOM 4785 O SER A 653 −39.338 16.692 −31.231 1.00 89.49 O ATOM 4786 N ASP A 654 −39.617 18.783 −32.021 1.00 87.24 N ATOM 4787 CA ASP A 654 −38.409 18.917 −32.844 1.00 87.91 C ATOM 4788 CB ASP A 654 −38.489 20.338 −33.512 1.00 98.92 C ATOM 4789 CG ASP A 654 −37.266 20.727 −34.408 1.00 109.69 C ATOM 4790 OD1 ASP A 654 −36.135 20.170 −34.319 1.00 119.68 O ATOM 4791 OD2 ASP A 654 −37.453 21.675 −35.205 1.00 106.65 O ATOM 4792 C ASP A 654 −37.157 18.713 −31.945 1.00 77.72 C ATOM 4793 O ASP A 654 −36.261 17.933 −32.286 1.00 77.62 O ATOM 4794 N ARG A 655 −37.129 19.389 −30.796 1.00 68.58 N ATOM 4795 CA ARG A 655 −36.006 19.357 −29.854 1.00 68.47 C ATOM 4796 CB ARG A 655 −35.391 20.787 −29.689 1.00 67.66 C ATOM 4797 C ARG A 655 −36.523 18.781 −28.515 1.00 65.30 C ATOM 4798 O ARG A 655 −36.958 19.536 −27.634 1.00 68.63 O ATOM 4799 N PRO A 656 −36.541 17.442 −28.367 1.00 60.64 N ATOM 4800 CA PRO A 656 −37.106 16.892 −27.121 1.00 58.54 C ATOM 4801 CB PRO A 656 −37.078 15.387 −27.320 1.00 57.58 C ATOM 4802 CG PRO A 656 −36.293 15.158 −28.565 1.00 59.72 C ATOM 4803 CD PRO A 656 −36.376 16.403 −29.383 1.00 60.73 C ATOM 4804 C PRO A 656 −36.309 17.285 −25.916 1.00 55.51 C ATOM 4805 O PRO A 656 −35.112 17.486 −26.020 1.00 55.58 O ATOM 4806 N THR A 657 −37.006 17.397 −24.797 1.00 53.39 N ATOM 4807 CA THR A 657 −36.574 18.180 −23.656 1.00 54.71 C ATOM 4808 CB THR A 657 −37.105 19.628 −23.794 1.00 56.27 C ATOM 4809 OG1 THR A 657 −36.967 20.080 −25.151 1.00 58.91 O ATOM 4810 CG2 THR A 657 −36.371 20.574 −22.901 1.00 56.70 C ATOM 4811 C THR A 657 −37.180 17.583 −22.400 1.00 56.39 C ATOM 4812 O THR A 657 −38.393 17.346 −22.353 1.00 61.12 O ATOM 4813 N VAL A 658 −36.359 17.324 −21.384 1.00 58.71 N ATOM 4814 CA VAL A 658 −36.869 16.970 −20.024 1.00 59.06 C ATOM 4815 CB VAL A 658 −35.986 15.900 −19.311 1.00 56.52 C ATOM 4816 CG1 VAL A 658 −36.319 15.775 −17.839 1.00 58.49 C ATOM 4817 CG2 VAL A 658 −36.188 14.542 −19.945 1.00 55.30 C ATOM 4818 C VAL A 658 −37.007 18.264 −19.193 1.00 56.81 C ATOM 4819 O VAL A 658 −36.281 19.228 −19.403 1.00 52.15 O ATOM 4820 N ILE A 659 −37.956 18.284 −18.276 1.00 56.07 N ATOM 4821 CA ILE A 659 −38.174 19.460 −17.498 1.00 64.05 C ATOM 4822 CB ILE A 659 −39.520 20.136 −17.934 1.00 68.95 C ATOM 4823 CG1 ILE A 659 −39.484 20.480 −19.448 1.00 67.64 C ATOM 4824 CD1 ILE A 659 −40.651 21.324 −19.952 1.00 65.99 C ATOM 4825 CG2 ILE A 659 −39.875 21.388 −17.098 1.00 67.14 C ATOM 4826 C ILE A 659 −38.122 19.073 −16.026 1.00 68.58 C ATOM 4827 O ILE A 659 −39.117 18.560 −15.522 1.00 68.06 O ATOM 4828 N TYR A 660 −36.972 19.304 −15.351 1.00 76.99 N ATOM 4829 CA TYR A 660 −36.880 19.173 −13.851 1.00 84.41 C ATOM 4830 CB TYR A 660 −35.672 18.334 −13.359 1.00 84.25 C ATOM 4831 CG TYR A 660 −34.328 18.524 −14.052 1.00 90.22 C ATOM 4832 CD1 TYR A 660 −33.548 19.683 −13.874 1.00 86.76 C ATOM 4833 CE1 TYR A 660 −32.305 19.821 −14.513 1.00 91.20 C ATOM 4834 CZ TYR A 660 −31.806 18.764 −15.326 1.00 103.59 C ATOM 4835 OH TYR A 660 −30.583 18.802 −16.006 1.00 104.30 O ATOM 4836 CE2 TYR A 660 −32.560 17.602 −15.479 1.00 105.58 C ATOM 4837 CD2 TYR A 660 −33.797 17.485 −14.840 1.00 101.76 C ATOM 4838 C TYR A 660 −36.937 20.524 −13.115 1.00 84.19 C ATOM 4839 O TYR A 660 −36.896 21.566 −13.759 1.00 82.53 O ATOM 4840 N SER A 661 −37.087 20.480 −11.781 1.00 85.46 N ATOM 4841 CA SER A 661 −36.863 21.640 −10.876 1.00 85.13 C ATOM 4842 CB SER A 661 −38.142 22.002 −10.096 1.00 88.65 C ATOM 4843 OG SER A 661 −38.024 23.283 −9.444 1.00 93.92 O ATOM 4844 C SER A 661 −35.679 21.464 −9.882 1.00 81.87 C ATOM 4845 O SER A 661 −35.807 20.854 −8.816 1.00 73.31 O ATOM 4846 N SER A 662 −34.531 22.011 −10.262 1.00 87.15 N ATOM 4847 CA SER A 662 −33.408 22.273 −9.342 1.00 90.26 C ATOM 4848 CB SER A 662 −32.083 22.285 −10.130 1.00 89.97 C ATOM 4849 OG SER A 662 −31.014 22.696 −9.316 1.00 86.37 O ATOM 4850 C SER A 662 −33.625 23.607 −8.553 1.00 89.03 C ATOM 4851 O SER A 662 −33.557 24.711 −9.125 1.00 77.65 O ATOM 4852 N ASN A 663 −33.856 23.457 −7.237 1.00 96.70 N ATOM 4853 CA ASN A 663 −34.270 24.530 −6.251 1.00 95.76 C ATOM 4854 CB ASN A 663 −33.090 25.163 −5.437 1.00 93.82 C ATOM 4855 CG ASN A 663 −31.873 25.516 −6.291 1.00 93.44 C ATOM 4856 OD1 ASN A 663 −31.799 26.598 −6.881 1.00 87.66 O ATOM 4857 ND2 ASN A 663 −30.891 24.609 −6.331 1.00 93.65 N ATOM 4858 C ASN A 663 −35.262 25.579 −6.750 1.00 92.61 C ATOM 4859 O ASN A 663 −34.904 26.730 −6.946 1.00 84.96 O ATOM 4860 N HIS A 664 −36.501 25.149 −6.988 1.00 95.91 N ATOM 4861 CA HIS A 664 −37.655 26.053 −7.157 1.00 99.99 C ATOM 4862 CB HIS A 664 −37.975 26.805 −5.831 1.00 100.50 C ATOM 4863 CG HIS A 664 −38.021 25.935 −4.595 1.00 104.51 C ATOM 4864 ND1 HIS A 664 −39.203 25.510 −4.020 1.00 108.35 N ATOM 4865 CE1 HIS A 664 −38.942 24.784 −2.945 1.00 104.96 C ATOM 4866 NE2 HIS A 664 −37.631 24.728 −2.796 1.00 103.91 N ATOM 4867 CD2 HIS A 664 −37.032 25.453 −3.801 1.00 103.52 C ATOM 4868 C HIS A 664 −37.532 27.077 −8.330 1.00 100.86 C ATOM 4869 O HIS A 664 −38.371 27.972 −8.439 1.00 98.22 O ATOM 4870 N LYS A 665 −36.474 26.979 −9.155 1.00 97.98 N ATOM 4871 CA LYS A 665 −36.417 27.558 −10.503 1.00 90.24 C ATOM 4872 CB LYS A 665 −35.187 28.463 −10.680 1.00 74.50 C ATOM 4873 C LYS A 665 −36.372 26.299 −11.417 1.00 98.09 C ATOM 4874 O LYS A 665 −35.722 25.303 −11.052 1.00 98.79 O ATOM 4875 N LEU A 666 −37.100 26.323 −12.554 1.00 99.17 N ATOM 4876 CA LEU A 666 −37.184 25.181 −13.519 1.00 89.34 C ATOM 4877 CB LEU A 666 −38.480 25.226 −14.335 1.00 85.75 C ATOM 4878 CG LEU A 666 −39.842 25.195 −13.632 1.00 88.23 C ATOM 4879 CD1 LEU A 666 −40.891 24.687 −14.609 1.00 91.44 C ATOM 4880 CD2 LEU A 666 −39.896 24.343 −12.376 1.00 86.29 C ATOM 4881 C LEU A 666 −36.033 25.136 −14.514 1.00 85.43 C ATOM 4882 O LEU A 666 −35.415 26.140 −14.807 1.00 91.41 O ATOM 4883 N VAL A 667 −35.777 23.963 −15.066 1.00 81.21 N ATOM 4884 CA VAL A 667 −34.634 23.755 −15.941 1.00 81.83 C ATOM 4885 CB VAL A 667 −33.522 23.057 −15.163 1.00 94.54 C ATOM 4886 CG1 VAL A 667 −32.299 22.735 −16.048 1.00 95.69 C ATOM 4887 CG2 VAL A 667 −33.176 23.899 −13.933 1.00 97.56 C ATOM 4888 C VAL A 667 −35.045 22.870 −17.088 1.00 75.61 C ATOM 4889 O VAL A 667 −35.942 22.046 −16.940 1.00 70.64 O ATOM 4890 N PHE A 668 −34.365 23.044 −18.217 1.00 69.17 N ATOM 4891 CA PHE A 668 −34.781 22.477 −19.463 1.00 62.53 C ATOM 4892 CB PHE A 668 −35.171 23.604 −20.411 1.00 64.94 C ATOM 4893 CG PHE A 668 −36.303 24.398 −19.913 1.00 67.08 C ATOM 4894 CD1 PHE A 668 −37.571 23.834 −19.861 1.00 70.00 C ATOM 4895 CE1 PHE A 668 −38.652 24.517 −19.350 1.00 69.97 C ATOM 4896 CZ PHE A 668 −38.468 25.782 −18.878 1.00 73.96 C ATOM 4897 CE2 PHE A 668 −37.194 26.355 −18.915 1.00 78.76 C ATOM 4898 CD2 PHE A 668 −36.113 25.653 −19.427 1.00 70.73 C ATOM 4899 C PHE A 668 −33.655 21.750 −20.043 1.00 61.12 C ATOM 4900 O PHE A 668 −33.106 22.189 −21.043 1.00 61.62 O ATOM 4901 N SER A 669 −33.281 20.634 −19.427 1.00 66.20 N ATOM 4902 CA SER A 669 −32.249 19.760 −20.050 1.00 67.28 C ATOM 4903 CB SER A 669 −31.779 18.616 −19.122 1.00 58.84 C ATOM 4904 C SER A 669 −32.809 19.284 −21.418 1.00 65.42 C ATOM 4905 O SER A 669 −33.964 18.885 −21.517 1.00 67.42 O ATOM 4906 N ASN A 670 −32.040 19.429 −22.482 1.00 63.51 N ATOM 4907 CA ASN A 670 −32.495 18.924 −23.739 1.00 64.55 C ATOM 4908 CB ASN A 670 −31.834 19.686 −24.867 1.00 74.76 C ATOM 4909 CG ASN A 670 −30.541 19.049 −25.314 1.00 80.84 C ATOM 4910 OD1 ASN A 670 −30.568 17.986 −25.949 1.00 89.08 O ATOM 4911 ND2 ASN A 670 −29.399 19.679 −24.990 1.00 81.28 N ATOM 4912 C ASN A 670 −32.174 17.435 −23.768 1.00 60.53 C ATOM 4913 O ASN A 670 −31.278 16.977 −23.060 1.00 59.53 O ATOM 4914 N VAL A 671 −32.912 16.688 −24.581 1.00 61.19 N ATOM 4915 CA VAL A 671 −32.800 15.210 −24.661 1.00 61.84 C ATOM 4916 CB VAL A 671 −34.167 14.463 −24.655 1.00 62.06 C ATOM 4917 CG1 VAL A 671 −34.030 13.010 −25.106 1.00 59.62 C ATOM 4918 CG2 VAL A 671 −34.809 14.507 −23.282 1.00 62.46 C ATOM 4919 C VAL A 671 −32.164 14.873 −25.969 1.00 59.04 C ATOM 4920 O VAL A 671 −32.575 15.337 −26.995 1.00 54.66 O ATOM 4921 N ASN A 672 −31.242 13.947 −25.912 1.00 62.71 N ATOM 4922 CA ASN A 672 −30.302 13.705 −26.977 1.00 64.62 C ATOM 4923 CB ASN A 672 −29.013 13.212 −26.288 1.00 69.38 C ATOM 4924 CG ASN A 672 −27.794 13.232 −27.167 1.00 75.88 C ATOM 4925 OD1 ASN A 672 −27.665 14.014 −28.131 1.00 83.22 O ATOM 4926 ND2 ASN A 672 −26.851 12.361 −26.818 1.00 81.08 N ATOM 4927 C ASN A 672 −30.912 12.716 −28.003 1.00 58.46 C ATOM 4928 O ASN A 672 −30.469 11.570 −28.123 1.00 55.36 O ATOM 4929 N LEU A 673 −31.926 13.190 −28.735 1.00 54.06 N ATOM 4930 CA LEU A 673 −32.608 12.401 −29.767 1.00 57.37 C ATOM 4931 CB LEU A 673 −33.808 11.709 −29.119 1.00 55.87 C ATOM 4932 CG LEU A 673 −33.551 10.393 −28.410 1.00 54.28 C ATOM 4933 CD1 LEU A 673 −34.778 9.963 −27.658 1.00 54.26 C ATOM 4934 CD2 LEU A 673 −33.196 9.335 −29.422 1.00 56.84 C ATOM 4935 C LEU A 673 −33.101 13.260 −30.968 1.00 62.71 C ATOM 4936 O LEU A 673 −33.365 14.452 −30.796 1.00 64.60 O ATOM 4937 N LYS A 674 −33.267 12.668 −32.172 1.00 65.52 N ATOM 4938 CA LYS A 674 −33.986 13.367 −33.281 1.00 65.12 C ATOM 4939 CB LYS A 674 −33.728 12.718 −34.665 1.00 59.13 C ATOM 4940 C LYS A 674 −35.459 13.377 −32.853 1.00 66.37 C ATOM 4941 O LYS A 674 −35.809 12.669 −31.947 1.00 74.61 O ATOM 4942 N GLU A 675 −36.329 14.152 −33.467 1.00 72.86 N ATOM 4943 CA GLU A 675 −37.681 14.344 −32.896 1.00 78.90 C ATOM 4944 CB GLU A 675 −38.599 15.205 −33.837 1.00 90.68 C ATOM 4945 CG GLU A 675 −39.396 14.577 −34.992 1.00 98.84 C ATOM 4946 CD GLU A 675 −40.611 15.468 −35.449 1.00 111.40 C ATOM 4947 OE1 GLU A 675 −41.580 14.880 −36.021 1.00 114.75 O ATOM 4948 OE2 GLU A 675 −40.631 16.738 −35.244 1.00 101.83 O ATOM 4949 C GLU A 675 −38.417 13.093 −32.284 1.00 72.50 C ATOM 4950 O GLU A 675 −38.468 12.014 −32.881 1.00 69.22 O ATOM 4951 N VAL A 676 −38.903 13.253 −31.051 1.00 62.01 N ATOM 4952 CA VAL A 676 −39.897 12.376 −30.464 1.00 58.72 C ATOM 4953 CB VAL A 676 −39.544 12.102 −29.013 1.00 58.53 C ATOM 4954 CG1 VAL A 676 −40.628 11.296 −28.296 1.00 61.40 C ATOM 4955 CG2 VAL A 676 −38.219 11.407 −28.958 1.00 58.85 C ATOM 4956 C VAL A 676 −41.261 13.095 −30.537 1.00 60.70 C ATOM 4957 O VAL A 676 −41.334 14.304 −30.241 1.00 59.76 O ATOM 4958 N ASN A 677 −42.319 12.373 −30.953 1.00 57.03 N ATOM 4959 CA ASN A 677 −43.637 12.969 −31.179 1.00 57.24 C ATOM 4960 CB ASN A 677 −44.331 12.426 −32.424 1.00 57.53 C ATOM 4961 CG ASN A 677 −43.656 12.815 −33.731 1.00 59.11 C ATOM 4962 OD1 ASN A 677 −43.031 13.833 −33.858 1.00 59.08 O ATOM 4963 ND2 ASN A 677 −43.811 11.979 −34.720 1.00 64.66 N ATOM 4964 C ASN A 677 −44.534 12.668 −30.004 1.00 61.49 C ATOM 4965 O ASN A 677 −45.293 13.555 −29.565 1.00 68.02 O ATOM 4966 N TYR A 678 −44.512 11.413 −29.530 1.00 57.34 N ATOM 4967 CA TYR A 678 −45.252 11.029 −28.307 1.00 54.62 C ATOM 4968 CB TYR A 678 −46.629 10.390 −28.596 1.00 53.87 C ATOM 4969 CG TYR A 678 −47.420 11.168 −29.604 1.00 56.60 C ATOM 4970 CD1 TYR A 678 −47.167 10.994 −30.936 1.00 61.65 C ATOM 4971 CE1 TYR A 678 −47.837 11.701 −31.905 1.00 67.35 C ATOM 4972 CZ TYR A 678 −48.782 12.622 −31.560 1.00 69.96 C ATOM 4973 OH TYR A 678 −49.396 13.279 −32.633 1.00 73.86 O ATOM 4974 CE2 TYR A 678 −49.053 12.841 −30.203 1.00 66.22 C ATOM 4975 CD2 TYR A 678 −48.368 12.110 −29.238 1.00 60.25 C ATOM 4976 C TYR A 678 −44.396 10.126 −27.441 1.00 53.27 C ATOM 4977 O TYR A 678 −43.398 9.520 −27.887 1.00 54.49 O ATOM 4978 N MET A 679 −44.752 10.089 −26.171 1.00 50.07 N ATOM 4979 CA MET A 679 −44.038 9.258 −25.247 1.00 49.89 C ATOM 4980 CB MET A 679 −42.807 9.962 −24.681 1.00 50.03 C ATOM 4981 CG MET A 679 −43.064 10.948 −23.570 1.00 49.55 C ATOM 4982 SD MET A 679 −43.152 10.114 −21.984 1.00 56.37 S ATOM 4983 CE MET A 679 −41.442 9.904 −21.564 1.00 59.95 C ATOM 4984 C MET A 679 −44.960 8.930 −24.144 1.00 50.29 C ATOM 4985 O MET A 679 −45.919 9.644 −23.904 1.00 51.65 O ATOM 4986 N CYS A 680 −44.640 7.860 −23.450 1.00 50.40 N ATOM 4987 CA CYS A 680 −45.348 7.502 −22.268 1.00 51.98 C ATOM 4988 CB CYS A 680 −46.549 6.626 −22.580 1.00 56.39 C ATOM 4989 SG CYS A 680 −46.200 4.866 −22.756 1.00 60.74 S ATOM 4990 C CYS A 680 −44.380 6.734 −21.484 1.00 52.09 C ATOM 4991 O CYS A 680 −43.472 6.153 −22.071 1.00 52.90 O ATOM 4992 N PRO A 681 −44.560 6.705 −20.156 1.00 55.78 N ATOM 4993 CA PRO A 681 −43.673 5.869 −19.343 1.00 55.05 C ATOM 4994 CB PRO A 681 −43.836 6.450 −17.924 1.00 53.13 C ATOM 4995 CG PRO A 681 −44.852 7.545 −18.031 1.00 51.17 C ATOM 4996 CD PRO A 681 −45.586 7.334 −19.310 1.00 52.62 C ATOM 4997 C PRO A 681 −44.175 4.442 −19.431 1.00 52.15 C ATOM 4998 O PRO A 681 −45.372 4.250 −19.643 1.00 52.00 O ATOM 4999 N LEU A 682 −43.265 3.842 −19.313 1.00 50.88 N ATOM 5000 CA LEU A 682 −43.596 2.054 −19.334 1.00 51.47 C ATOM 5001 CB LEU A 682 −43.175 1.392 −20.642 1.00 51.81 C ATOM 5002 CG LEU A 682 −43.496 −0.098 −20.848 1.00 48.57 C ATOM 5003 CD1 LEU A 682 −44.952 −0.161 −21.148 1.00 51.74 C ATOM 5004 CD2 LEU A 682 −42.776 −0.733 −22.015 1.00 48.58 C ATOM 5005 C LEU A 682 −42.848 1.337 −18.250 1.00 54.37 C ATOM 5006 O LEU A 682 −41.601 1.429 −18.168 1.00 50.79 O ATOM 5007 N ASN A 683 −43.605 0.567 −17.467 1.00 57.70 N ATOM 5008 CA ASN A 683 −43.029 −0.298 −16.458 1.00 59.45 C ATOM 5009 CB ASN A 683 −43.432 0.212 −15.105 1.00 59.83 C ATOM 5010 CG ASN A 683 −42.631 −0.386 −14.014 1.00 60.80 C ATOM 5011 OD1 ASN A 683 −41.873 −1.328 −14.191 1.00 71.33 O ATOM 5012 ND2 ASN A 683 −42.757 0.187 −12.881 1.00 62.78 N ATOM 5013 C ASN A 683 −43.457 −1.752 −16.629 1.00 60.25 C ATOM 5014 O ASN A 683 −44.478 −2.172 −16.122 1.00 61.74 O ATOM 5015 N SER A 684 −42.647 −2.505 −17.355 1.00 62.13 N ATOM 5016 CA SER A 684 −42.859 −3.921 −17.560 1.00 64.37 C ATOM 5017 CB SER A 684 −42.684 −4.268 −19.032 1.00 67.15 C ATOM 5018 OG SER A 684 −43.700 −3.599 −19.713 1.00 75.86 O ATOM 5019 C SER A 684 −41.861 −4.679 −16.769 1.00 62.93 C ATOM 5020 O SER A 684 −40.893 −4.126 −16.239 1.00 61.62 O ATOM 5021 N ASP A 685 −42.095 −5.973 −16.732 1.00 63.53 N ATOM 5022 CA ASP A 685 −41.166 −6.922 −16.144 1.00 67.91 C ATOM 5023 CB ASP A 685 −41.841 −8.298 −16.084 1.00 76.80 C ATOM 5024 CG ASP A 685 −43.303 −8.198 −15.663 1.00 87.48 C ATOM 5025 OD1 ASP A 685 −44.106 −7.606 −16.459 1.00 95.44 O ATOM 5026 OD2 ASP A 685 −43.621 −8.644 −14.528 1.00 97.31 O ATOM 5027 C ASP A 685 −39.889 −6.931 −16.993 1.00 62.90 C ATOM 5028 O ASP A 685 −38.787 −6.800 −16.459 1.00 60.26 O ATOM 5029 N GLY A 686 −40.063 −7.025 −18.317 1.00 60.80 N ATOM 5030 CA GLY A 686 −38.968 −6.911 −19.280 1.00 57.20 C ATOM 5031 C GLY A 686 −38.333 −5.542 −19.469 1.00 54.07 C ATOM 5032 O GLY A 686 −37.155 −5.445 −19.735 1.00 47.77 O ATOM 5033 N TYR A 687 −39.121 −4.483 −19.343 1.00 55.98 N ATOM 5034 CA TYR A 687 −38.629 −3.121 −19.466 1.00 54.89 C ATOM 5035 CB TYR A 687 −39.160 −2.482 −20.788 1.00 54.91 C ATOM 5036 CG TYR A 687 −38.832 −3.300 −22.032 1.00 56.22 C ATOM 5037 CD1 TYR A 687 −37.521 −3.514 −22.428 1.00 55.33 C ATOM 5038 CE1 TYR A 687 −37.219 −4.298 −23.552 1.00 58.54 C ATOM 5039 CZ TYR A 687 −38.230 −4.909 −24.313 1.00 57.46 C ATOM 5040 OH TYR A 687 −37.915 −5.695 −25.456 1.00 57.21 O ATOM 5041 CE2 TYR A 687 −39.534 −4.697 −23.923 1.00 57.27 C ATOM 5042 CD2 TYR A 687 −39.830 −3.892 −22.799 1.00 58.66 C ATOM 5043 C TYR A 687 −39.056 −2.367 −18.186 1.00 55.00 C ATOM 5044 O TYR A 687 −39.901 −1.490 −18.242 1.00 60.85 O ATOM 5045 N PRO A 688 −38.477 −2.696 −17.007 1.00 54.46 N ATOM 5046 CA PRO A 688 −38.843 −1.946 −15.795 1.00 54.57 C ATOM 5047 CB PRO A 688 −38.133 −2.714 −14.702 1.00 52.65 C ATOM 5048 CG PRO A 688 −36.885 −3.163 −15.354 1.00 51.41 C ATOM 5049 CD PRO A 688 −37.370 −3.615 −16.712 1.00 54.30 C ATOM 5050 C PRO A 688 −38.331 −0.511 −15.777 1.00 54.17 C ATOM 5051 O PRO A 688 −37.220 −0.246 −16.200 1.00 47.26 O ATOM 5052 N ASP A 689 −39.144 0.391 −15.249 1.00 58.82 N ATOM 5053 CA ASP A 689 −38.756 1.809 −15.069 1.00 63.70 C ATOM 5054 CB ASP A 689 −37.660 2.018 −13.989 1.00 67.61 C ATOM 5055 CG ASP A 689 −38.080 1.526 −12.604 1.00 70.84 C ATOM 5056 OD1 ASP A 689 −39.281 1.723 −12.191 1.00 63.64 O ATOM 5057 OD2 ASP A 689 −37.162 0.935 −11.971 1.00 72.02 O ATOM 5058 C ASP A 689 −38.288 2.423 −16.348 1.00 57.45 C ATOM 5059 O ASP A 689 −37.297 3.063 −16.366 1.00 55.54 O ATOM 5060 N SER A 690 −39.044 2.247 −17.408 1.00 59.02 N ATOM 5061 CA SER A 690 −38.595 2.623 −18.710 1.00 56.00 C ATOM 5062 CB SER A 690 −38.534 1.367 −19.564 1.00 59.63 C ATOM 5063 OG SER A 690 −37.848 0.344 −18.876 1.00 61.66 O ATOM 5064 C SER A 690 −39.527 3.637 −19.302 1.00 51.01 C ATOM 5065 O SER A 690 −40.495 4.016 −18.666 1.00 55.51 O ATOM 5066 N LEU A 691 −39.205 4.044 −20.526 1.00 47.82 N ATOM 5067 CA LEU A 691 −39.969 4.945 −21.369 1.00 48.62 C ATOM 5068 CB LEU A 691 −39.047 6.078 −21.759 1.00 48.94 C ATOM 5069 CG LEU A 691 −39.154 7.337 −20.949 1.00 54.49 C ATOM 5070 CD1 LEU A 691 −39.354 7.106 −19.446 1.00 57.36 C ATOM 5071 CD2 LEU A 691 −37.909 8.179 −21.258 1.00 56.04 C ATOM 5072 C LEU A 691 −40.351 4.301 −22.672 1.00 47.10 C ATOM 5073 O LEU A 691 −39.468 3.693 −23.236 1.00 49.41 O ATOM 5074 N ALA A 692 −41.577 4.487 −23.197 1.00 45.43 N ATOM 5075 CA ALA A 692 −41.835 4.288 −24.671 1.00 48.25 C ATOM 5076 CB ALA A 692 −43.148 3.618 −24.919 1.00 48.67 C ATOM 5077 C ALA A 692 −41.837 5.557 −25.490 1.00 50.61 C ATOM 5078 O ALA A 692 −42.633 6.436 −25.238 1.00 57.53 O ATOM 5079 N LEU A 693 −40.989 5.662 −26.496 1.00 50.55 N ATOM 5080 CA LEU A 693 −40.994 6.852 −27.328 1.00 49.81 C ATOM 5081 CB LEU A 693 −39.599 7.463 −27.426 1.00 49.95 C ATOM 5082 CG LEU A 693 −38.711 8.041 −26.324 1.00 49.19 C ATOM 5083 CD1 LEU A 693 −39.459 8.173 −25.031 1.00 52.91 C ATOM 5084 CD2 LEU A 693 −37.486 7.195 −26.131 1.00 48.81 C ATOM 5085 C LEU A 693 −41.399 6.451 −28.736 1.00 50.36 C ATOM 5086 O LEU A 693 −40.856 5.472 −29.290 1.00 48.06 O ATOM 5087 N ALA A 694 −42.293 7.235 −29.340 1.00 49.72 N ATOM 5088 CA ALA A 694 −42.555 7.121 −30.780 1.00 48.81 C ATOM 5089 CB ALA A 694 −43.991 6.788 −31.043 1.00 47.35 C ATOM 5090 C ALA A 694 −42.213 8.365 −31.547 1.00 50.55 C ATOM 5091 O ALA A 694 −42.244 9.463 −31.017 1.00 55.06 O ATOM 5092 N ASN A 695 −41.938 8.174 −32.824 1.00 52.27 N ATOM 5093 CA ASN A 695 −41.879 9.254 −33.762 1.00 55.01 C ATOM 5094 CB ASN A 695 −40.418 9.563 −33.988 1.00 57.80 C ATOM 5095 CG ASN A 695 −39.733 8.504 −34.789 1.00 57.41 C ATOM 5096 OD1 ASN A 695 −40.370 7.794 −35.547 1.00 65.18 O ATOM 5097 ND2 ASN A 695 −38.447 8.374 −34.618 1.00 56.29 N ATOM 5098 C ASN A 695 −42.578 8.839 −35.048 1.00 57.36 C ATOM 5099 O ASN A 695 −43.276 7.828 −35.081 1.00 64.89 O ATOM 5100 N ASN A 696 −42.330 9.551 −36.134 1.00 64.53 N ATOM 5101 CA ASN A 696 −43.073 9.314 −37.372 1.00 71.45 C ATOM 5102 CB ASN A 696 −42.698 10.363 −38.435 1.00 80.19 C ATOM 5103 CG ASN A 696 −43.283 11.736 −38.100 1.00 89.55 C ATOM 5104 OD1 ASN A 696 −42.551 12.712 −37.825 1.00 92.20 O ATOM 5105 ND2 ASN A 696 −44.624 11.795 −38.027 1.00 89.56 N ATOM 5106 C ASN A 696 −42.966 7.883 −37.883 1.00 66.64 C ATOM 5107 O ASN A 696 −43.967 7.334 −38.328 1.00 65.96 O ATOM 5108 N SER A 697 −41.789 7.270 −37.743 1.00 61.51 N ATOM 5109 CA SER A 697 −41.553 5.884 −38.213 1.00 61.77 C ATOM 5110 CB SER A 697 −40.394 5.899 −39.206 1.00 59.25 C ATOM 5111 OG SER A 697 −39.277 6.536 −38.631 1.00 57.45 O ATOM 5112 C SER A 697 −41.356 4.729 −37.154 1.00 58.36 C ATOM 5113 O SER A 697 −41.533 3.534 −37.479 1.00 54.97 O ATOM 5114 N THR A 698 −41.044 5.067 −35.908 1.00 55.57 N ATOM 5115 CA THR A 698 −40.576 4.060 −34.973 1.00 57.09 C ATOM 5116 CB THR A 698 −39.077 4.123 −34.957 1.00 60.73 C ATOM 5117 OG1 THR A 698 −38.649 4.685 −36.200 1.00 59.81 O ATOM 5118 CG2 THR A 698 −38.493 2.738 −34.768 1.00 65.77 C ATOM 5119 C THR A 698 −41.026 4.186 −33.524 1.00 55.35 C ATOM 5120 O THR A 698 −41.213 5.281 −33.027 1.00 57.29 O ATOM 5121 N LEU A 699 −41.238 3.036 −32.888 1.00 52.44 N ATOM 5122 CA LEU A 699 −41.426 2.925 −31.452 1.00 50.67 C ATOM 5123 CB LEU A 699 −42.527 1.921 −31.135 1.00 48.36 C ATOM 5124 CG LEU A 699 −42.931 1.703 −29.676 1.00 45.90 C ATOM 5125 CD1 LEU A 699 −43.374 2.993 −29.015 1.00 47.19 C ATOM 5126 CD2 LEU A 699 −44.042 0.683 −29.540 1.00 43.75 C ATOM 5127 C LEU A 699 −40.104 2.427 −30.880 1.00 52.52 C ATOM 5128 O LEU A 699 −39.472 1.503 −31.411 1.00 58.36 O ATOM 5129 N THR A 700 −39.693 3.044 −29.793 1.00 49.75 N ATOM 5130 CA THR A 700 −38.459 2.744 −29.141 1.00 45.53 C ATOM 5131 CB THR A 700 −37.512 3.934 −29.399 1.00 45.44 C ATOM 5132 OG1 THR A 700 −36.804 3.723 −30.611 1.00 49.74 O ATOM 5133 CG2 THR A 700 −36.480 4.102 −28.355 1.00 46.63 C ATOM 5134 C THR A 700 −38.853 2.550 −27.665 1.00 46.95 C ATOM 5135 O THR A 700 −39.775 3.194 −27.149 1.00 45.85 O ATOM 5136 N ILE A 701 −38.167 1.643 −26.989 1.00 49.65 N ATOM 5137 CA ILE A 701 −38.294 1.458 −25.551 1.00 50.31 C ATOM 5138 CB ILE A 701 −38.790 0.046 −25.210 1.00 51.59 C ATOM 5139 CG1 ILE A 701 −40.211 −0.083 −25.783 1.00 52.95 C ATOM 5140 CD1 ILE A 701 −40.959 −1.331 −25.403 1.00 55.63 C ATOM 5141 CG2 ILE A 701 −38.718 −0.200 −23.693 1.00 51.77 C ATOM 5142 C ILE A 701 −36.951 1.657 −24.959 1.00 51.19 C ATOM 5143 O ILE A 701 −36.007 1.102 −25.496 1.00 49.11 O ATOM 5144 N GLY A 702 −36.868 2.400 −23.844 1.00 57.29 N ATOM 5145 CA GLY A 702 −35.560 2.718 −23.197 1.00 59.03 C ATOM 5146 C GLY A 702 −35.561 3.313 −21.783 1.00 58.57 C ATOM 5147 O GLY A 702 −36.481 4.006 −21.436 1.00 68.88 O ATOM 5148 N THR A 703 −34.529 2.981 −20.983 1.00 59.10 N ATOM 5149 CA THR A 703 −34.058 3.650 −19.754 1.00 50.25 C ATOM 5150 CB THR A 703 −32.944 2.820 −19.065 1.00 41.16 C ATOM 5151 C THR A 703 −33.504 5.037 −20.210 1.00 53.17 C ATOM 5152 O THR A 703 −33.300 5.299 −21.396 1.00 52.93 O ATOM 5153 N ILE A 704 −33.240 5.908 −19.254 1.00 58.63 N ATOM 5154 CA ILE A 704 −32.943 7.330 −19.483 1.00 57.59 C ATOM 5155 CB ILE A 704 −34.224 8.131 −19.374 1.00 59.07 C ATOM 5156 CG1 ILE A 704 −33.945 9.624 −19.141 1.00 56.84 C ATOM 5157 CD1 ILE A 704 −34.896 10.505 −19.937 1.00 57.75 C ATOM 5158 CG2 ILE A 704 −35.152 7.537 −18.284 1.00 63.43 C ATOM 5159 C ILE A 704 −32.056 7.819 −18.374 1.00 59.98 C ATOM 5160 O ILE A 704 −32.294 7.472 −17.241 1.00 62.49 O ATOM 5161 N ASP A 705 −31.058 8.635 −18.674 1.00 63.19 N ATOM 5162 CA ASP A 705 −30.088 9.074 −17.652 1.00 65.77 C ATOM 5163 CB ASP A 705 −28.770 9.377 −18.320 1.00 64.61 C ATOM 5164 CG ASP A 705 −28.256 8.159 −19.026 1.00 68.32 C ATOM 5165 OD1 ASP A 705 −29.110 7.235 −19.227 1.00 66.67 O ATOM 5166 OD2 ASP A 705 −27.049 8.082 −19.353 1.00 67.75 O ATOM 5167 C ASP A 705 −30.681 10.205 −16.850 1.00 69.98 C ATOM 5168 O ASP A 705 −31.639 10.831 −17.339 1.00 64.42 O ATOM 5169 N GLU A 706 −30.203 10.398 −15.602 1.00 75.04 N ATOM 5170 CA GLU A 706 −30.958 11.219 −14.598 1.00 77.04 C ATOM 5171 CB GLU A 706 −30.781 10.651 −13.165 1.00 66.52 C ATOM 5172 C GLU A 706 −30.658 12.758 −14.706 1.00 74.29 C ATOM 5173 O GLU A 706 −31.535 13.592 −15.050 1.00 73.20 O ATOM 5174 N ILE A 707 −28.116 13.596 −14.378 1.00 79.57 N ATOM 5175 CA ILE A 707 −27.132 14.378 −15.082 1.00 79.03 C ATOM 5176 CB ILE A 707 −25.667 13.910 −14.796 1.00 68.63 C ATOM 5177 C ILE A 707 −27.488 14.284 −16.586 1.00 84.54 C ATOM 5178 O ILE A 707 −28.311 13.406 −17.028 1.00 73.38 O ATOM 5179 N GLN A 708 −26.828 15.190 −17.292 1.00 81.36 N ATOM 5180 CA GLN A 708 −26.804 15.412 −18.702 1.00 76.39 C ATOM 5181 CB GLN A 708 −26.823 16.892 −18.988 1.00 72.03 C ATOM 5182 CG GLN A 708 −28.063 17.469 −19.614 1.00 76.89 C ATOM 5183 CD GLN A 708 −27.768 18.786 −20.292 1.00 76.83 C ATOM 5184 OE1 GLN A 708 −26.670 19.306 −20.186 1.00 82.87 O ATOM 5185 NE2 GLN A 708 −28.741 19.322 −20.998 1.00 71.97 N ATOM 5186 C GLN A 708 −25.365 15.075 −18.721 1.00 80.30 C ATOM 5187 O GLN A 708 −24.730 15.168 −17.691 1.00 88.09 O ATOM 5188 N LYS A 709 −24.824 14.682 −19.849 1.00 66.65 N ATOM 5189 CA LYS A 709 −23.427 14.340 −19.900 1.00 58.32 C ATOM 5190 CB LYS A 709 −23.234 12.865 −19.594 1.00 49.68 C ATOM 5191 C LYS A 709 −23.029 14.635 −21.289 1.00 55.83 C ATOM 5192 O LYS A 709 −23.863 14.982 −22.085 1.00 47.94 O ATOM 5193 N LEU A 710 −21.754 14.521 −21.586 1.00 51.92 N ATOM 5194 CA LEU A 710 −21.304 14.737 −22.926 1.00 48.90 C ATOM 5195 CB LEU A 710 −19.933 15.356 −22.931 1.00 46.48 C ATOM 5196 CG LEU A 710 −19.913 16.822 −22.585 1.00 46.79 C ATOM 5197 CD1 LEU A 710 −18.575 17.371 −22.975 1.00 45.74 C ATOM 5198 CD2 LEU A 710 −20.984 17.541 −23.352 1.00 48.87 C ATOM 5199 C LEU A 710 −21.242 13.364 −23.514 1.00 47.86 C ATOM 5200 O LEU A 710 −20.682 12.482 −22.924 1.00 42.97 O ATOM 5201 N HIS A 711 −21.838 13.195 −24.680 1.00 49.56 N ATOM 5202 CA HIS A 711 −21.881 11.928 −25.362 1.00 49.22 C ATOM 5203 CB HIS A 711 −23.289 11.640 −25.780 1.00 51.17 C ATOM 5204 CG HIS A 711 −24.200 11.439 −24.623 1.00 57.46 C ATOM 5205 ND1 HIS A 711 −24.854 12.475 −24.010 1.00 59.83 N ATOM 5206 CE1 HIS A 711 −25.569 12.010 −23.008 1.00 62.96 C ATOM 5207 NE2 HIS A 711 −25.384 10.710 −22.939 1.00 64.67 N ATOM 5208 CD2 HIS A 711 −24.530 10.329 −23.936 1.00 60.08 C ATOM 5209 C HIS A 711 −20.970 12.005 −26.526 1.00 50.66 C ATOM 5210 O HIS A 711 −20.934 12.991 −27.196 1.00 54.62 O ATOM 5211 N ILE A 712 −20.215 10.948 −26.738 1.00 52.56 N ATOM 5212 CA ILE A 712 −19.161 10.873 −27.775 1.00 49.95 C ATOM 5213 CB ILE A 712 −17.811 10.648 −27.062 1.00 48.95 C ATOM 5214 CG1 ILE A 712 −17.663 11.685 −25.959 1.00 47.88 C ATOM 5215 CD1 ILE A 712 −16.307 11.711 −25.323 1.00 48.98 C ATOM 5216 CG2 ILE A 712 −16.662 10.728 −28.041 1.00 49.60 C ATOM 5217 C ILE A 712 −19.332 9.774 −28.820 1.00 46.59 C ATOM 5218 O ILE A 712 −19.141 8.647 −28.508 1.00 45.24 O ATOM 5219 N ARG A 713 −19.620 10.141 −30.065 1.00 51.26 N ATOM 5220 CA ARG A 713 −19.638 9.228 −31.251 1.00 54.48 C ATOM 5221 CB ARG A 713 −20.597 9.788 −32.343 1.00 59.83 C ATOM 5222 CG ARG A 713 −21.460 8.818 −33.197 1.00 69.65 C ATOM 5223 CD ARG A 713 −20.670 8.210 −34.411 1.00 77.11 C ATOM 5224 NE ARG A 713 −21.408 7.579 −35.541 1.00 69.92 N ATOM 5225 CZ ARG A 713 −22.075 8.249 −36.479 1.00 68.09 C ATOM 5226 NH1 ARG A 713 −22.199 9.570 −36.433 1.00 69.35 N ATOM 5227 NH2 ARG A 713 −22.656 7.598 −37.462 1.00 70.97 N ATOM 5228 C ARG A 713 −18.207 9.148 −31.795 1.00 51.87 C ATOM 5229 O ARG A 713 −17.547 10.154 −31.939 1.00 51.43 O ATOM 5230 N THR A 714 −17.712 7.949 −32.074 1.00 52.62 N ATOM 5231 CA THR A 714 −16.366 7.773 −32.650 1.00 49.92 C ATOM 5232 CB THR A 714 −15.515 6.846 −31.759 1.00 49.94 C ATOM 5233 OG1 THR A 714 −15.348 7.436 −30.472 1.00 51.86 O ATOM 5234 CG2 THR A 714 −14.166 6.676 −32.268 1.00 52.10 C ATOM 5235 C THR A 714 −16.421 7.312 −34.129 1.00 47.68 C ATOM 5236 O THR A 714 −17.322 6.636 −34.549 1.00 49.18 O ATOM 5237 N VAL A 715 −15.449 7.771 −34.905 1.00 47.87 N ATOM 5238 CA VAL A 715 −15.317 7.551 −36.339 1.00 44.73 C ATOM 5239 CB VAL A 715 −15.720 8.770 −37.119 1.00 40.73 C ATOM 5240 CG1 VAL A 715 −15.381 8.595 −38.596 1.00 38.02 C ATOM 5241 CG2 VAL A 715 −17.187 9.027 −36.863 1.00 41.29 C ATOM 5242 C VAL A 715 −13.859 7.304 −36.629 1.00 48.86 C ATOM 5243 O VAL A 715 −13.044 8.254 −36.685 1.00 46.74 O ATOM 5244 N PRO A 716 −13.507 6.017 −36.745 1.00 49.60 N ATOM 5245 CA PRO A 716 −12.104 5.715 −36.943 1.00 48.49 C ATOM 5246 CB PRO A 716 −12.033 4.263 −36.618 1.00 47.33 C ATOM 5247 CG PRO A 716 −12.989 4.188 −35.491 1.00 48.87 C ATOM 5248 CD PRO A 716 −14.167 4.943 −36.013 1.00 46.96 C ATOM 5249 C PRO A 716 −11.725 5.949 −38.344 1.00 47.49 C ATOM 5250 O PRO A 716 −12.528 5.700 −39.214 1.00 50.17 O ATOM 5251 N LEU A 717 −10.520 6.487 −38.497 1.00 48.39 N ATOM 5252 CA LEU A 717 −9.820 6.753 −39.751 1.00 46.53 C ATOM 5253 CB LEU A 717 −9.378 8.213 −39.747 1.00 45.87 C ATOM 5254 CG LEU A 717 −10.480 9.247 −39.492 1.00 47.59 C ATOM 5255 CD1 LEU A 717 −9.900 10.653 −39.484 1.00 48.76 C ATOM 5256 CD2 LEU A 717 −11.605 9.178 −40.513 1.00 47.26 C ATOM 5257 C LEU A 717 −8.557 5.881 −39.947 1.00 46.07 C ATOM 5258 O LEU A 717 −8.123 5.672 −41.053 1.00 48.53 O ATOM 5259 N TYR A 718 −7.917 5.413 −38.888 1.00 46.57 N ATOM 5260 CA TYR A 718 −6.731 4.577 −39.042 1.00 45.34 C ATOM 5261 CB TYR A 718 −7.084 3.256 −39.728 1.00 42.62 C ATOM 5262 CG TYR A 718 −8.303 2.553 −39.117 1.00 42.23 C ATOM 5263 CD1 TYR A 718 −8.165 1.666 −37.983 1.00 42.75 C ATOM 5264 CE1 TYR A 718 −9.277 1.042 −37.400 1.00 40.03 C ATOM 5265 CZ TYR A 718 −10.515 1.266 −37.958 1.00 40.60 C ATOM 5266 OH TYR A 718 −11.603 0.701 −37.403 1.00 46.97 O ATOM 5267 CE2 TYR A 718 −10.697 2.089 −39.081 1.00 40.54 C ATOM 5268 CD2 TYR A 718 −9.601 2.747 −39.645 1.00 39.67 C ATOM 5269 C TYR A 718 −5.534 5.325 −39.700 1.00 48.31 C ATOM 5270 O TYR A 718 −4.471 4.710 −39.975 1.00 49.91 O ATOM 5271 N GLU A 719 −5.693 6.647 −39.876 1.00 47.81 N ATOM 5272 CA GLU A 719 −4.590 7.569 −40.188 1.00 49.67 C ATOM 5273 CB GLU A 719 −4.548 7.920 −41.694 1.00 51.48 C ATOM 5274 CG GLU A 719 −5.781 8.671 −42.177 1.00 56.32 C ATOM 5275 CD GLU A 719 −6.001 8.709 −43.681 1.00 61.67 C ATOM 5276 OE1 GLU A 719 −6.698 9.643 −44.128 1.00 65.51 O ATOM 5277 OE2 GLU A 719 −5.542 7.816 −44.424 1.00 68.52 O ATOM 5278 C GLU A 719 −4.772 8.828 −39.315 1.00 46.96 C ATOM 5279 O GLU A 719 −5.846 9.022 −38.766 1.00 45.78 O ATOM 5280 N SER A 720 −3.744 9.665 −39.213 1.00 44.21 N ATOM 5281 CA SER A 720 −3.845 10.949 −38.517 1.00 47.26 C ATOM 5282 CB SER A 720 −2.452 11.561 −38.418 1.00 50.66 C ATOM 5283 OG SER A 720 −1.533 10.642 −37.898 1.00 55.93 O ATOM 5284 C SER A 720 −4.715 12.052 −39.161 1.00 48.78 C ATOM 5285 O SER A 720 −4.367 12.543 −40.243 1.00 54.30 O ATOM 5286 N PRO A 721 −5.804 12.502 −38.490 1.00 47.20 N ATOM 5287 CA PRO A 721 −6.459 13.729 −38.950 1.00 44.98 C ATOM 5288 CB PRO A 721 −7.847 13.636 −38.356 1.00 43.56 C ATOM 5289 CG PRO A 721 −7.734 12.698 −37.224 1.00 44.75 C ATOM 5290 CD PRO A 721 −6.389 12.043 −37.226 1.00 45.48 C ATOM 5291 C PRO A 721 −5.735 14.888 −38.359 1.00 46.62 C ATOM 5292 O PRO A 721 −5.080 14.737 −37.315 1.00 54.55 O ATOM 5293 N ARG A 722 −5.850 16.034 −39.004 1.00 48.10 N ATOM 5294 CA ARG A 722 −4.980 17.206 −38.727 1.00 47.94 C ATOM 5295 CB ARG A 722 −3.762 17.156 −39.651 1.00 47.06 C ATOM 5296 CG ARG A 722 −2.854 15.939 −39.441 1.00 51.18 C ATOM 5297 CD ARG A 722 −1.476 16.277 −38.874 1.00 59.11 C ATOM 5298 NE ARG A 722 −1.608 16.734 −37.473 1.00 68.52 N ATOM 5299 CZ ARG A 722 −0.849 17.653 −36.854 1.00 71.01 C ATOM 5300 NH1 ARG A 722 −1.121 17.982 −35.601 1.00 71.35 N ATOM 5301 NH2 ARG A 722 0.170 18.256 −37.460 1.00 72.75 N ATOM 5302 C ARG A 722 −5.684 18.618 −38.746 1.00 45.71 C ATOM 5303 O ARG A 722 −5.390 19.484 −37.872 1.00 48.12 O ATOM 5304 N LYS A 723 −6.576 18.845 −39.706 1.00 41.14 N ATOM 5305 CA LYS A 723 −7.538 19.925 −39.639 1.00 41.62 C ATOM 5306 CB LYS A 723 −7.127 21.054 −40.569 1.00 42.53 C ATOM 5307 CG LYS A 723 −5.730 21.611 −40.401 1.00 42.82 C ATOM 5308 CD LYS A 723 −5.481 22.542 −39.223 1.00 41.05 C ATOM 5309 CE LYS A 723 −3.965 22.485 −39.068 1.00 43.31 C ATOM 5310 NZ LYS A 723 −3.470 23.084 −37.808 1.00 46.56 N ATOM 5311 C LYS A 723 −8.903 19.488 −40.111 1.00 41.85 C ATOM 5312 O LYS A 723 −9.017 18.525 −40.788 1.00 48.71 O ATOM 5313 N ILE A 724 −9.924 20.264 −39.851 1.00 41.18 N ATOM 5314 CA ILE A 724 −11.283 19.893 −40.175 1.00 43.37 C ATOM 5315 CB ILE A 724 −11.895 19.000 −39.066 1.00 45.86 C ATOM 5316 CG1 ILE A 724 −13.421 18.931 −39.181 1.00 49.09 C ATOM 5317 CD1 ILE A 724 −14.015 17.713 −38.506 1.00 50.66 C ATOM 5318 CG2 ILE A 724 −11.622 19.549 −37.676 1.00 44.74 C ATOM 5319 C ILE A 724 −12.082 21.183 −40.308 1.00 45.30 C ATOM 5320 O ILE A 724 −11.788 22.138 −39.651 1.00 47.75 O ATOM 5321 N CYS A 725 −13.057 21.242 −41.187 1.00 48.38 N ATOM 5322 CA CYS A 725 −13.978 22.376 −41.206 1.00 54.98 C ATOM 5323 CB CYS A 725 −13.389 23.558 −41.969 1.00 59.42 C ATOM 5324 SG CYS A 725 −13.327 23.199 −43.727 1.00 68.77 S ATOM 5325 C CYS A 725 −15.265 21.900 −41.859 1.00 54.58 C ATOM 5326 O CYS A 725 −15.280 20.799 −42.430 1.00 57.12 O ATOM 5327 N TYR A 726 −16.328 22.697 −41.807 1.00 49.54 N ATOM 5328 CA TYR A 726 −17.600 22.193 −42.239 1.00 48.24 C ATOM 5329 CB TYR A 726 −18.443 22.079 −41.057 1.00 45.78 C ATOM 5330 CG TYR A 726 −19.873 21.853 −41.266 1.00 47.59 C ATOM 5331 CD1 TYR A 726 −20.357 20.610 −41.545 1.00 49.52 C ATOM 5332 CE1 TYR A 726 −21.727 20.399 −41.664 1.00 51.45 C ATOM 5333 CZ TYR A 726 −22.619 21.444 −41.464 1.00 49.83 C ATOM 5334 OH TYR A 726 −23.985 21.278 −41.547 1.00 48.71 O ATOM 5335 CE2 TYR A 726 −22.136 22.679 −41.166 1.00 50.90 C ATOM 5336 CD2 TYR A 726 −20.776 22.873 −41.050 1.00 49.96 C ATOM 5337 C TYR A 726 −18.235 23.079 −43.261 1.00 54.98 C ATOM 5338 O TYR A 726 −18.295 24.276 −43.091 1.00 60.20 O ATOM 5339 N GLN A 727 −18.721 22.462 −44.336 1.00 61.93 N ATOM 5340 CA GLN A 727 −19.256 23.166 −45.472 1.00 58.71 C ATOM 5341 CB GLN A 727 −18.533 22.725 −46.711 1.00 56.49 C ATOM 5342 CG GLN A 727 −18.759 23.627 −47.904 1.00 57.51 C ATOM 5343 CD GLN A 727 −17.775 23.310 −49.005 1.00 58.47 C ATOM 5344 OE1 GLN A 727 −18.119 22.569 −49.985 1.00 58.11 O ATOM 5345 NE2 GLN A 727 −16.520 23.691 −48.810 1.00 59.21 N ATOM 5346 C GLN A 727 −20.705 22.790 −45.473 1.00 60.73 C ATOM 5347 O GLN A 727 −21.078 21.804 −46.042 1.00 62.76 O ATOM 5348 N GLU A 728 −21.502 23.575 −44.756 1.00 65.41 N ATOM 5349 CA GLU A 728 −22.928 23.348 −44.611 1.00 63.72 C ATOM 5350 CB GLU A 728 −23.576 24.559 −43.975 1.00 67.76 C ATOM 5351 CG GLU A 728 −24.784 24.187 −43.147 1.00 73.01 C ATOM 5352 CD GLU A 728 −25.947 25.098 −43.387 1.00 77.34 C ATOM 5353 OE1 GLU A 728 −26.265 25.901 −42.468 1.00 82.89 O ATOM 5354 OE2 GLU A 728 −26.509 24.999 −44.504 1.00 80.40 O ATOM 5355 C GLU A 728 −23.678 23.039 −45.915 1.00 60.34 C ATOM 5356 O GLU A 728 −24.427 22.065 −45.991 1.00 54.80 O ATOM 5357 N VAL A 729 −23.462 23.841 −46.946 1.00 59.75 N ATOM 5358 CA VAL A 729 −24.123 23.569 −48.255 1.00 59.35 C ATOM 5359 CB VAL A 729 −23.798 24.612 −49.343 1.00 56.28 C ATOM 5360 CG1 VAL A 729 −24.098 25.996 −48.822 1.00 57.49 C ATOM 5361 CG2 VAL A 729 −22.343 24.554 −49.772 1.00 59.31 C ATOM 5362 C VAL A 729 −23.884 22.148 −48.803 1.00 54.69 C ATOM 5363 O VAL A 729 −24.820 21.480 −49.182 1.00 59.85 O ATOM 5364 N SER A 730 −22.668 21.656 −48.780 1.00 49.35 N ATOM 5365 CA SER A 730 −22.416 20.325 −49.264 1.00 51.96 C ATOM 5366 CB SER A 730 −20.957 20.190 −49.553 1.00 52.87 C ATOM 5367 OG SER A 730 −20.462 21.436 −49.935 1.00 54.50 O ATOM 5368 C SER A 730 −22.805 19.256 −48.259 1.00 57.86 C ATOM 5369 O SER A 730 −22.755 18.053 −48.574 1.00 61.22 O ATOM 5370 N GLN A 731 −23.140 19.698 −47.037 1.00 61.02 N ATOM 5371 CA GLN A 731 −23.544 18.852 −45.926 1.00 56.56 C ATOM 5372 CB GLN A 731 −24.826 18.108 −46.249 1.00 58.30 C ATOM 5373 CG GLN A 731 −26.024 19.011 −46.215 1.00 64.38 C ATOM 5374 CD GLN A 731 −27.015 18.557 −45.191 1.00 72.67 C ATOM 5375 OE1 GLN A 731 −27.547 17.433 −45.280 1.00 80.48 O ATOM 5376 NE2 GLN A 731 −27.263 19.408 −44.185 1.00 75.24 N ATOM 5377 C GLN A 731 −22.459 17.900 −45.608 1.00 55.04 C ATOM 5378 O GLN A 731 −22.692 16.738 −45.479 1.00 55.96 O ATOM 5379 N CYS A 732 −21.238 18.389 −45.533 1.00 58.54 N ATOM 5380 CA CYS A 732 −20.109 17.510 −45.310 1.00 65.40 C ATOM 5381 CB CYS A 732 −19.658 16.942 −46.638 1.00 73.95 C ATOM 5382 SG CYS A 732 −18.736 18.204 −47.486 1.00 95.62 S ATOM 5383 C CYS A 732 −18.964 18.266 −44.625 1.00 61.00 C ATOM 5384 O CYS A 732 −19.079 19.466 −44.349 1.00 60.13 O ATOM 5385 N PHE A 733 −17.887 17.531 −44.342 1.00 57.90 N ATOM 5386 CA PHE A 733 −16.724 18.006 −43.602 1.00 53.53 C ATOM 5387 CB PHE A 733 −16.492 17.156 −42.342 1.00 52.15 C ATOM 5388 CG PHE A 733 −17.400 17.471 −41.194 1.00 49.64 C ATOM 5389 CD1 PHE A 733 −17.187 18.582 −40.417 1.00 50.46 C ATOM 5390 CE1 PHE A 733 −18.011 18.903 −39.375 1.00 48.71 C ATOM 5391 CZ PHE A 733 −19.025 18.083 −39.062 1.00 49.65 C ATOM 5392 CE2 PHE A 733 −19.201 16.933 −39.792 1.00 52.01 C ATOM 5393 CD2 PHE A 733 −18.399 16.642 −40.860 1.00 48.56 C ATOM 5394 C PHE A 733 −15.480 17.857 −44.453 1.00 52.44 C ATOM 5395 O PHE A 733 −15.220 16.805 −45.045 1.00 50.62 O ATOM 5396 N GLY A 734 −14.678 18.898 −44.461 1.00 52.55 N ATOM 5397 CA GLY A 734 −13.328 18.800 −44.987 1.00 51.61 C ATOM 5398 C GLY A 734 −12.407 18.360 −43.883 1.00 48.38 C ATOM 5399 O GLY A 734 −12.482 18.882 −42.795 1.00 49.23 O ATOM 5400 N VAL A 735 −11.541 17.398 −44.150 1.00 45.98 N ATOM 5401 CA VAL A 735 −10.526 17.030 −43.178 1.00 44.64 C ATOM 5402 CB VAL A 735 −10.979 15.760 −42.447 1.00 41.78 C ATOM 5403 CG1 VAL A 735 −9.865 15.195 −41.585 1.00 39.85 C ATOM 5404 CG2 VAL A 735 −12.200 16.085 −41.597 1.00 42.84 C ATOM 5405 C VAL A 735 −9.120 16.837 −43.762 1.00 44.05 C ATOM 5406 O VAL A 735 −8.913 15.860 −44.480 1.00 43.66 O ATOM 5407 N LEU A 736 −8.155 17.714 −43.449 1.00 41.58 N ATOM 5408 CA LEU A 736 −6.768 17.396 −43.828 1.00 42.73 C ATOM 5409 CB LEU A 736 −5.815 18.547 −43.604 1.00 41.97 C ATOM 5410 CG LEU A 736 −6.181 19.766 −44.428 1.00 44.21 C ATOM 5411 CD1 LEU A 736 −5.288 20.962 −44.145 1.00 43.13 C ATOM 5412 CD2 LEU A 736 −6.135 19.411 −45.897 1.00 46.71 C ATOM 5413 C LEU A 736 −6.301 16.188 −43.043 1.00 44.51 C ATOM 5414 O LEU A 736 −6.528 16.123 −41.843 1.00 43.99 O ATOM 5415 N SER A 737 −5.695 15.210 −43.705 1.00 44.96 N ATOM 5416 CA SER A 737 −5.263 14.015 −42.983 1.00 50.56 C ATOM 5417 CB SER A 737 −6.308 12.877 −43.074 1.00 54.12 C ATOM 5418 OG SER A 737 −6.620 12.158 −44.315 1.00 59.88 O ATOM 5419 C SER A 737 −3.917 13.540 −43.469 1.00 52.13 C ATOM 5420 O SER A 737 −3.391 14.061 −44.472 1.00 51.84 O ATOM 5421 N SER A 738 −3.358 12.540 −42.782 1.00 49.36 N ATOM 5422 CA SER A 738 −1.989 12.209 −43.059 1.00 50.97 C ATOM 5423 CB SER A 738 −1.099 13.233 −42.371 1.00 49.20 C ATOM 5424 OG SER A 738 0.060 12.654 −41.827 1.00 53.78 O ATOM 5425 C SER A 738 −1.616 10.795 −42.698 1.00 54.82 C ATOM 5426 O SER A 738 −1.418 10.490 −41.515 1.00 65.88 O ATOM 5427 N ARG A 739 −1.468 9.938 −43.716 1.00 54.94 N ATOM 5428 CA ARG A 739 −1.058 8.550 −43.488 1.00 52.99 C ATOM 5429 CB ARG A 739 −1.921 7.608 −44.314 1.00 57.72 C ATOM 5430 CG ARG A 739 −1.565 7.469 −45.781 1.00 60.40 C ATOM 5431 CD ARG A 739 −2.528 6.529 −46.494 1.00 62.54 C ATOM 5432 NE ARG A 739 −1.995 6.171 −47.810 1.00 63.69 N ATOM 5433 CZ ARG A 739 −2.067 6.921 −48.911 1.00 63.51 C ATOM 5434 NH1 ARG A 739 −2.690 8.117 −48.954 1.00 59.73 N ATOM 5435 NH2 ARG A 739 −1.493 6.452 −50.003 1.00 67.76 N ATOM 5436 C ARG A 739 0.417 8.325 −43.767 1.00 48.33 C ATOM 5437 O ARG A 739 0.994 9.047 −44.589 1.00 45.54 O ATOM 5438 N ILE A 740 1.003 7.341 −43.073 1.00 44.99 N ATOM 5439 CA ILE A 740 2.397 6.927 −43.298 1.00 49.18 C ATOM 5440 CB ILE A 740 3.096 6.434 −41.994 1.00 51.04 C ATOM 5441 CG1 ILE A 740 3.030 7.451 −40.871 1.00 51.26 C ATOM 5442 CD1 ILE A 740 3.667 8.768 −41.257 1.00 54.17 C ATOM 5443 CG2 ILE A 740 4.561 6.122 −42.255 1.00 51.41 C ATOM 5444 C ILE A 740 2.538 5.752 −44.259 1.00 52.24 C ATOM 5445 O ILE A 740 2.026 4.665 −43.988 1.00 50.30 O ATOM 5446 N GLU A 741 3.284 5.949 −45.346 1.00 61.29 N ATOM 5447 CA GLU A 741 3.775 4.835 −46.188 1.00 65.42 C ATOM 5448 CB GLU A 741 3.401 5.055 −47.662 1.00 68.99 C ATOM 5449 CG GLU A 741 1.865 5.062 −47.837 1.00 77.65 C ATOM 5450 CD GLU A 741 1.317 4.694 −49.232 1.00 82.38 C ATOM 5451 OE1 GLU A 741 1.941 5.027 −50.275 1.00 88.15 O ATOM 5452 OE2 GLU A 741 0.215 4.090 −49.279 1.00 76.98 O ATOM 5453 C GLU A 741 5.279 4.595 −45.974 1.00 67.75 C ATOM 5454 O GLU A 741 6.035 5.514 −45.672 1.00 69.67 O ATOM 5455 N VAL A 742 5.689 3.335 −46.050 1.00 72.61 N ATOM 5456 CA VAL A 742 7.116 2.965 −46.079 1.00 75.15 C ATOM 5457 CB VAL A 742 7.434 1.771 −45.109 1.00 77.42 C ATOM 5458 CG1 VAL A 742 6.888 0.427 −45.620 1.00 78.75 C ATOM 5459 CG2 VAL A 742 8.937 1.693 −44.815 1.00 77.67 C ATOM 5460 C VAL A 742 7.483 2.714 −47.559 1.00 72.72 C ATOM 5461 O VAL A 742 6.627 2.241 −48.334 1.00 67.03 O ATOM 5462 N GLN A 743 8.733 3.049 −47.940 1.00 76.55 N ATOM 5463 CA GLN A 743 9.191 3.078 −49.376 1.00 79.17 C ATOM 5464 CB GLN A 743 10.457 3.972 −49.560 1.00 74.06 C ATOM 5465 C GLN A 743 9.374 1.676 −50.047 1.00 78.20 C ATOM 5466 O GLN A 743 9.778 0.707 −49.393 1.00 68.87 O ATOM 5467 N ASP A 744 9.041 1.603 −51.346 1.00 84.87 N ATOM 5468 CA ASP A 744 9.091 0.376 −52.174 1.00 85.64 C ATOM 5469 CB ASP A 744 7.766 0.226 −52.971 1.00 77.29 C ATOM 5470 C ASP A 744 10.324 0.492 −53.103 1.00 87.75 C ATOM 5471 O ASP A 744 10.907 −0.500 −53.569 1.00 94.14 O ATOM 5472 N THR A 749 6.128 3.468 −53.040 1.00 76.60 N ATOM 5473 CA THR A 749 5.813 3.619 −51.594 1.00 79.57 C ATOM 5474 CB THR A 749 5.924 5.111 −51.131 1.00 78.61 C ATOM 5475 OG1 THR A 749 6.263 5.138 −49.748 1.00 80.65 O ATOM 5476 CG2 THR A 749 4.629 5.987 −51.353 1.00 76.66 C ATOM 5477 C THR A 749 4.466 2.987 −51.149 1.00 75.93 C ATOM 5478 O THR A 749 3.437 3.199 −51.806 1.00 77.89 O ATOM 5479 N THR A 750 4.464 2.198 −50.065 1.00 73.26 N ATOM 5480 CA THR A 750 3.217 1.459 −49.678 1.00 79.60 C ATOM 5481 CB THR A 750 3.256 −0.096 −49.969 1.00 78.51 C ATOM 5482 OG1 THR A 750 3.812 −0.815 −48.853 1.00 73.55 O ATOM 5483 CG2 THR A 750 3.993 −0.448 −51.345 1.00 78.40 C ATOM 5484 C THR A 750 2.648 1.687 −48.247 1.00 82.28 C ATOM 5485 O THR A 750 3.377 1.927 −47.268 1.00 82.62 O ATOM 5486 N ALA A 751 1.317 1.585 −48.181 1.00 77.95 N ATOM 5487 CA ALA A 751 0.538 1.657 −46.951 1.00 72.25 C ATOM 5488 CB ALA A 751 −0.929 1.525 −47.307 1.00 71.59 C ATOM 5489 C ALA A 751 0.913 0.567 −45.954 1.00 67.93 C ATOM 5490 O ALA A 751 1.304 −0.509 −46.357 1.00 73.04 O ATOM 5491 N LEU A 752 0.793 0.857 −44.663 1.00 65.50 N ATOM 5492 CA LEU A 752 0.999 −0.142 −43.596 1.00 64.85 C ATOM 5493 CB LEU A 752 1.705 0.481 −42.359 1.00 69.61 C ATOM 5494 CG LEU A 752 2.910 1.442 −42.540 1.00 72.77 C ATOM 5495 CD1 LEU A 752 3.525 1.954 −41.233 1.00 72.08 C ATOM 5496 CD2 LEU A 752 3.979 0.751 −43.382 1.00 76.11 C ATOM 5497 C LEU A 752 −0.340 −0.780 −43.178 1.00 57.63 C ATOM 5498 O LEU A 752 −0.347 −1.748 −42.412 1.00 55.45 O ATOM 5499 N ARG A 753 −1.450 −0.239 −43.695 1.00 51.99 N ATOM 5500 CA ARG A 753 −2.814 −0.642 −43.324 1.00 50.79 C ATOM 5501 CB ARG A 753 −3.080 −0.458 −41.806 1.00 53.20 C ATOM 5502 CG ARG A 753 −3.486 0.954 −41.370 1.00 56.86 C ATOM 5503 CD ARG A 753 −3.258 1.273 −39.893 1.00 56.58 C ATOM 5504 NE ARG A 753 −1.843 1.411 −39.589 1.00 56.24 N ATOM 5505 CZ ARG A 753 −1.120 0.525 −38.892 1.00 60.89 C ATOM 5506 NH1 ARG A 753 −1.667 −0.614 −38.374 1.00 59.80 N ATOM 5507 NH2 ARG A 753 0.189 0.773 −38.715 1.00 59.28 N ATOM 5508 C ARG A 753 −3.824 0.178 −44.129 1.00 46.93 C ATOM 5509 O ARG A 753 −3.524 1.284 −44.516 1.00 46.97 O ATOM 5510 N PRO A 754 −5.028 −0.343 −44.368 1.00 48.09 N ATOM 5511 CA PRO A 754 −6.074 0.532 −44.922 1.00 51.04 C ATOM 5512 CB PRO A 754 −7.265 −0.416 −45.201 1.00 48.34 C ATOM 5513 CG PRO A 754 −6.929 −1.678 −44.539 1.00 48.18 C ATOM 5514 CD PRO A 754 −5.439 −1.748 −44.393 1.00 49.24 C ATOM 5515 C PRO A 754 −6.494 1.617 −43.940 1.00 55.19 C ATOM 5516 O PRO A 754 −6.550 1.353 −42.687 1.00 56.92 O ATOM 5517 N SER A 755 −6.799 2.782 −44.527 1.00 51.92 N ATOM 5518 CA SER A 755 −6.920 4.056 −43.827 1.00 51.43 C ATOM 5519 CB SER A 755 −5.658 4.930 −44.010 1.00 50.82 C ATOM 5520 OG SER A 755 −4.402 4.251 −43.782 1.00 54.74 O ATOM 5521 C SER A 755 −8.037 4.759 −44.496 1.00 51.27 C ATOM 5522 O SER A 755 −8.314 4.492 −45.629 1.00 58.00 O ATOM 5523 N ALA A 756 −8.636 5.718 −43.839 1.00 52.45 N ATOM 5524 CA ALA A 756 −9.659 6.567 −44.463 1.00 53.80 C ATOM 5525 CB ALA A 756 −9.886 7.825 −43.618 1.00 55.36 C ATOM 5526 C ALA A 756 −9.391 6.996 −45.909 1.00 51.79 C ATOM 5527 O ALA A 756 −10.296 6.977 −46.706 1.00 49.37 O ATOM 5528 N SER A 757 −8.170 7.405 −46.221 1.00 51.27 N ATOM 5529 CA SER A 757 −7.883 8.042 −47.488 1.00 52.39 C ATOM 5530 CB SER A 757 −6.656 8.934 −47.394 1.00 51.93 C ATOM 5531 OG SER A 757 −5.495 8.218 −47.031 1.00 51.59 O ATOM 5532 C SER A 757 −7.651 7.050 −48.600 1.00 59.30 C ATOM 5533 O SER A 757 −7.647 7.445 −49.773 1.00 71.46 O ATOM 5534 N THR A 758 −7.437 5.781 −48.251 1.00 57.50 N ATOM 5535 CA THR A 758 −7.285 4.737 −49.230 1.00 55.75 C ATOM 5536 CB THR A 758 −6.252 3.714 −48.781 1.00 52.77 C ATOM 5537 OG1 THR A 758 −6.801 2.942 −47.719 1.00 51.41 O ATOM 5538 CG2 THR A 758 −4.940 4.373 −48.334 1.00 51.62 C ATOM 5539 C THR A 758 −8.604 3.991 −49.419 1.00 61.80 C ATOM 5540 O THR A 758 −8.685 3.080 −50.223 1.00 73.22 O ATOM 5541 N GLN A 759 −9.593 4.337 −48.625 1.00 63.04 N ATOM 5542 CA GLN A 759 −10.867 3.665 −48.656 1.00 61.91 C ATOM 5543 CB GLN A 759 −11.124 3.072 −47.295 1.00 68.86 C ATOM 5544 CG GLN A 759 −10.052 2.118 −46.853 1.00 75.86 C ATOM 5545 CD GLN A 759 −10.428 0.703 −47.164 1.00 87.45 C ATOM 5546 OE1 GLN A 759 −11.398 0.188 −46.630 1.00 91.04 O ATOM 5547 NE2 GLN A 759 −9.671 0.066 −48.044 1.00 94.78 N ATOM 5548 C GLN A 759 −12.045 4.512 −49.017 1.00 58.43 C ATOM 5549 O GLN A 759 −13.161 4.165 −48.696 1.00 55.04 O ATOM 5550 N ALA A 760 −11.812 5.638 −49.648 1.00 54.66 N ATOM 5551 CA ALA A 760 −12.904 6.509 −50.005 1.00 58.38 C ATOM 5552 CB ALA A 760 −12.374 7.884 −50.293 1.00 62.42 C ATOM 5553 C ALA A 760 −13.723 6.003 −51.171 1.00 58.58 C ATOM 5554 O ALA A 760 −13.226 5.287 −52.019 1.00 57.93 O ATOM 5555 N LEU A 761 −14.981 6.397 −51.226 1.00 57.47 N ATOM 5556 CA LEU A 761 −15.821 5.978 −52.311 1.00 60.90 C ATOM 5557 CB LEU A 761 −17.168 6.641 −52.198 1.00 65.34 C ATOM 5558 CG LEU A 761 −18.310 5.816 −51.673 1.00 71.31 C ATOM 5559 CD1 LEU A 761 −18.129 5.673 −50.182 1.00 76.35 C ATOM 5560 CD2 LEU A 761 −19.594 6.546 −51.976 1.00 71.93 C ATOM 5561 C LEU A 761 −15.257 6.476 −53.595 1.00 63.83 C ATOM 5562 O LEU A 761 −15.165 5.745 −54.551 1.00 76.54 O ATOM 5563 N SER A 762 −14.859 7.727 −53.620 1.00 66.18 N ATOM 5564 CA SER A 762 −14.327 8.299 −54.826 1.00 63.80 C ATOM 5565 CB SER A 762 −15.212 9.426 −55.301 1.00 63.55 C ATOM 5566 C SER A 762 −12.987 8.807 −54.444 1.00 67.64 C ATOM 5567 O SER A 762 −12.781 9.143 −53.314 1.00 74.10 O ATOM 5568 N SER A 763 −12.050 8.824 −55.362 1.00 69.32 N ATOM 5569 CA SER A 763 −10.723 9.253 −55.025 1.00 62.27 C ATOM 5570 CB SER A 763 −9.889 8.032 −54.725 1.00 52.41 C ATOM 5571 OG SER A 763 −8.530 8.313 −54.882 1.00 51.34 O ATOM 5572 C SER A 763 −10.117 10.097 −56.138 1.00 65.71 C ATOM 5573 O SER A 763 −10.643 10.137 −57.232 1.00 65.51 O ATOM 5574 N SER A 764 −9.020 10.783 −55.835 1.00 68.55 N ATOM 5575 CA SER A 764 −8.342 11.663 −56.780 1.00 63.22 C ATOM 5576 CB SER A 764 −9.062 12.995 −56.841 1.00 59.59 C ATOM 5577 OG SER A 764 −10.086 13.058 −55.875 1.00 54.09 O ATOM 5578 C SER A 764 −6.906 11.912 −56.410 1.00 61.97 C ATOM 5579 O SER A 764 −6.497 11.592 −55.328 1.00 64.80 O ATOM 5580 N VAL A 765 −6.131 12.469 −57.323 1.00 64.08 N ATOM 5581 CA VAL A 765 −4.747 12.814 −57.040 1.00 66.59 C ATOM 5582 CB VAL A 765 −3.781 11.756 −57.503 1.00 69.96 C ATOM 5583 CG1 VAL A 765 −3.812 11.680 −59.003 1.00 77.00 C ATOM 5584 CG2 VAL A 765 −2.393 12.117 −57.050 1.00 74.57 C ATOM 5585 C VAL A 765 −4.452 14.145 −57.711 1.00 64.39 C ATOM 5586 O VAL A 765 −4.980 14.424 −58.765 1.00 62.18 O ATOM 5587 N SER A 766 −3.623 14.977 −57.104 1.00 68.25 N ATOM 5588 CA SER A 766 −3.362 16.291 −57.666 1.00 69.32 C ATOM 5589 CB SER A 766 −2.633 17.184 −56.669 1.00 66.76 C ATOM 5590 OG SER A 766 −3.528 18.044 −55.993 1.00 61.42 O ATOM 5591 C SER A 766 −2.597 16.281 −58.944 1.00 73.08 C ATOM 5592 O SER A 766 −1.567 15.646 −59.050 1.00 67.81 O ATOM 5593 N SER A 767 −3.101 17.028 −59.912 1.00 83.75 N ATOM 5594 CA SER A 767 −2.440 17.140 −61.188 1.00 90.72 C ATOM 5595 CB SER A 767 −3.281 17.987 −62.118 1.00 92.56 C ATOM 5596 OG SER A 767 −3.432 19.292 −61.580 1.00 87.31 O ATOM 5597 C SER A 767 −1.220 17.924 −60.860 1.00 91.61 C ATOM 5598 O SER A 767 −1.315 18.970 −60.232 1.00 87.08 O ATOM 5599 N SER A 768 −0.077 17.471 −61.324 1.00 92.66 N ATOM 5600 CA SER A 768 1.141 18.171 −61.012 1.00 91.91 C ATOM 5601 CB SER A 768 2.317 17.439 −61.624 1.00 91.80 C ATOM 5602 OG SER A 768 2.093 16.049 −61.555 1.00 87.17 O ATOM 5603 C SER A 768 1.008 19.556 −61.584 1.00 93.91 C ATOM 5604 O SER A 768 0.303 19.758 −62.547 1.00 85.32 O ATOM 5605 N LYS A 769 1.644 20.530 −60.961 1.00 99.81 N ATOM 5606 CA LYS A 769 1.569 21.887 −61.460 1.00 94.83 C ATOM 5607 CB LYS A 769 2.515 22.794 −60.682 1.00 86.30 C ATOM 5608 C LYS A 769 1.980 21.886 −62.910 1.00 85.29 C ATOM 5609 O LYS A 769 3.123 21.584 −63.218 1.00 78.46 O ATOM 5610 N GLU A 784 11.997 2.667 −45.192 1.00 62.91 N ATOM 5611 CA GLU A 784 12.128 4.093 −44.697 1.00 70.32 C ATOM 5612 CB GLU A 784 13.452 4.790 −45.104 1.00 66.51 C ATOM 5613 C GLU A 784 10.938 4.989 −45.091 1.00 68.45 C ATOM 5614 O GLU A 784 10.414 4.867 −46.175 1.00 70.62 O ATOM 5615 N GLU A 785 10.573 5.916 −44.208 1.00 69.95 N ATOM 5616 CA GLU A 785 9.163 6.319 −43.998 1.00 72.36 C ATOM 5617 CB GLU A 785 8.916 6.594 −42.498 1.00 72.85 C ATOM 5618 CG GLU A 785 9.398 5.525 −41.532 1.00 70.52 C ATOM 5619 CD GLU A 785 8.374 5.250 −40.464 1.00 69.13 C ATOM 5620 OE1 GLU A 785 7.875 6.215 −39.903 1.00 64.77 O ATOM 5621 OE2 GLU A 785 8.036 4.075 −40.206 1.00 78.62 O ATOM 5622 C GLU A 785 8.753 7.588 −44.712 1.00 67.73 C ATOM 5623 O GLU A 785 9.582 8.456 −44.864 1.00 68.03 O ATOM 5624 N VAL A 786 7.470 7.739 −45.048 1.00 61.40 N ATOM 5625 CA VAL A 786 7.011 8.985 −45.659 1.00 61.69 C ATOM 5626 CB VAL A 786 7.336 8.943 −47.162 1.00 63.93 C ATOM 5627 CG1 VAL A 786 6.316 8.122 −47.912 1.00 63.46 C ATOM 5628 CG2 VAL A 786 7.402 10.357 −47.733 1.00 71.15 C ATOM 5629 C VAL A 786 5.531 9.416 −45.414 1.00 58.42 C ATOM 5630 O VAL A 786 4.629 8.590 −45.308 1.00 60.35 O ATOM 5631 N GLU A 787 5.288 10.721 −45.350 1.00 52.26 N ATOM 5632 CA GLU A 787 3.967 11.226 −44.983 1.00 52.42 C ATOM 5633 CB GLU A 787 4.097 12.562 −44.235 1.00 56.71 C ATOM 5634 CG GLU A 787 3.195 12.797 −43.041 1.00 58.96 C ATOM 5635 CD GLU A 787 3.957 13.389 −41.875 1.00 65.62 C ATOM 5636 OE1 GLU A 787 3.714 14.571 −41.498 1.00 70.37 O ATOM 5637 OE2 GLU A 787 4.813 12.644 −41.332 1.00 71.05 O ATOM 5638 C GLU A 787 3.277 11.460 −46.275 1.00 50.08 C ATOM 5639 O GLU A 787 3.921 11.845 −47.221 1.00 52.66 O ATOM 5640 N VAL A 788 1.971 11.253 −46.330 1.00 50.76 N ATOM 5641 CA VAL A 788 1.188 11.527 −47.554 1.00 51.39 C ATOM 5642 CB VAL A 788 0.825 10.228 −48.314 1.00 48.89 C ATOM 5643 CG1 VAL A 788 −0.030 10.543 −49.541 1.00 48.41 C ATOM 5644 CG2 VAL A 788 2.082 9.488 −48.705 1.00 47.61 C ATOM 5645 C VAL A 788 −0.118 12.216 −47.218 1.00 51.76 C ATOM 5646 O VAL A 788 −0.985 11.639 −46.515 1.00 55.38 O ATOM 5647 N HIS A 789 −0.296 13.406 −47.755 1.00 48.71 N ATOM 5648 CA HIS A 789 −1.401 14.218 −47.308 1.00 53.19 C ATOM 5649 CB HIS A 789 −0.962 15.649 −47.173 1.00 55.97 C ATOM 5650 CG HIS A 789 −0.003 15.836 −46.057 1.00 58.74 C ATOM 5651 ND1 HIS A 789 −0.176 16.788 −45.088 1.00 62.78 N ATOM 5652 CE1 HIS A 789 0.823 16.721 −44.228 1.00 62.85 C ATOM 5653 NE2 HIS A 789 1.616 15.731 −44.585 1.00 60.30 N ATOM 5654 CD2 HIS A 789 1.113 15.150 −45.720 1.00 60.58 C ATOM 5655 C HIS A 789 −2.622 14.106 −48.177 1.00 52.04 C ATOM 5656 O HIS A 789 −2.515 13.854 −49.369 1.00 54.55 O ATOM 5657 N ASN A 790 −3.780 14.233 −47.541 1.00 47.69 N ATOM 5658 CA ASN A 790 −5.027 14.125 −48.211 1.00 47.56 C ATOM 5659 CB ASN A 790 −5.618 12.740 −47.998 1.00 51.17 C ATOM 5660 CG ASN A 790 −4.774 11.642 −48.623 1.00 57.01 C ATOM 5661 OD1 ASN A 790 −4.941 11.253 −49.824 1.00 53.98 O ATOM 5662 ND2 ASN A 790 −3.865 11.096 −47.792 1.00 62.86 N ATOM 5663 C ASN A 790 −6.007 15.126 −47.702 1.00 45.62 C ATOM 5664 O ASN A 790 −5.902 15.575 −46.577 1.00 48.62 O ATOM 5665 N LEU A 791 −6.992 15.439 −48.524 1.00 42.73 N ATOM 5666 CA LEU A 791 −8.118 16.175 −48.091 1.00 42.70 C ATOM 5667 CB LEU A 791 −8.318 17.420 −48.943 1.00 44.67 C ATOM 5668 CG LEU A 791 −9.674 18.127 −48.718 1.00 46.67 C ATOM 5669 CD1 LEU A 791 −9.908 18.595 −47.280 1.00 46.84 C ATOM 5670 CD2 LEU A 791 −9.757 19.307 −49.644 1.00 48.11 C ATOM 5671 C LEU A 791 −9.293 15.230 −48.199 1.00 42.77 C ATOM 5672 O LEU A 791 −9.798 15.001 −49.274 1.00 41.71 O ATOM 5673 N LEU A 792 −9.743 14.715 −47.062 1.00 43.09 N ATOM 5674 CA LEU A 792 −10.933 13.886 −47.010 1.00 43.95 C ATOM 5675 CB LEU A 792 −10.991 13.067 −45.722 1.00 42.52 C ATOM 5676 CG LEU A 792 −9.746 12.285 −45.361 1.00 43.99 C ATOM 5677 CD1 LEU A 792 −9.949 11.581 −44.024 1.00 44.27 C ATOM 5678 CD2 LEU A 792 −9.416 11.307 −46.469 1.00 45.32 C ATOM 5679 C LEU A 792 −12.184 14.768 −47.088 1.00 45.74 C ATOM 5680 O LEU A 792 −12.141 15.918 −46.693 1.00 47.28 O ATOM 5681 N ILE A 793 −13.289 14.193 −47.562 1.00 45.59 N ATOM 5682 CA ILE A 793 −14.574 14.835 −47.578 1.00 46.09 C ATOM 5683 CB ILE A 793 −15.026 15.154 −49.003 1.00 46.84 C ATOM 5684 CG1 ILE A 793 −13.965 16.021 −49.680 1.00 47.90 C ATOM 5685 CD1 ILE A 793 −13.778 17.398 −49.073 1.00 49.84 C ATOM 5686 CG2 ILE A 793 −16.418 15.802 −49.008 1.00 45.71 C ATOM 5687 C ILE A 793 −15.502 13.841 −47.003 1.00 46.62 C ATOM 5688 O ILE A 793 −15.635 12.781 −47.565 1.00 53.06 O ATOM 5689 N ILE A 794 −16.153 14.185 −45.903 1.00 46.41 N ATOM 5690 CA ILE A 794 −16.775 13.196 −45.037 1.00 45.57 C ATOM 5691 CB ILE A 794 −15.939 13.064 −43.758 1.00 44.49 C ATOM 5692 CG1 ILE A 794 −14.608 12.444 −44.159 1.00 45.90 C ATOM 5693 CD1 ILE A 794 −13.656 12.171 −43.035 1.00 47.13 C ATOM 5694 CG2 ILE A 794 −16.601 12.174 −42.743 1.00 43.64 C ATOM 5695 C ILE A 794 −18.221 13.557 −44.782 1.00 47.65 C ATOM 5696 O ILE A 794 −18.574 14.692 −44.553 1.00 48.49 O ATOM 5697 N ASP A 795 −19.092 12.579 −44.858 1.00 53.49 N ATOM 5698 CA ASP A 795 −20.507 12.887 −44.818 1.00 56.81 C ATOM 5699 CB ASP A 795 −21.363 11.652 −45.151 1.00 60.10 C ATOM 5700 CG ASP A 795 −22.771 12.031 −45.480 1.00 63.62 C ATOM 5701 OD1 ASP A 795 −22.935 12.533 −46.594 1.00 66.51 O ATOM 5702 OD2 ASP A 795 −23.684 11.907 −44.634 1.00 64.19 O ATOM 5703 C ASP A 795 −20.884 13.422 −43.441 1.00 55.44 C ATOM 5704 O ASP A 795 −20.482 12.884 −42.389 1.00 51.95 O ATOM 5705 N GLN A 796 −21.668 14.479 −43.461 1.00 54.74 N ATOM 5706 CA GLN A 796 −22.214 15.045 −42.225 1.00 55.31 C ATOM 5707 CB GLN A 796 −23.069 16.261 −42.557 1.00 55.91 C ATOM 5708 CG GLN A 796 −24.283 16.460 −41.697 1.00 58.45 C ATOM 5709 CD GLN A 796 −24.773 17.864 −41.749 1.00 59.07 C ATOM 5710 OE1 GLN A 796 −25.444 18.319 −40.830 1.00 65.50 O ATOM 5711 NE2 GLN A 796 −24.457 18.557 −42.808 1.00 58.50 N ATOM 5712 C GLN A 796 −23.004 14.101 −41.340 1.00 54.48 C ATOM 5713 O GLN A 796 −22.821 14.148 −40.117 1.00 51.06 O ATOM 5714 N HIS A 797 −23.899 13.300 −41.941 1.00 58.39 N ATOM 5715 CA HIS A 797 −24.810 12.380 −41.174 1.00 62.66 C ATOM 5716 CB HIS A 797 −26.150 12.161 −41.855 1.00 63.23 C ATOM 5717 CG HIS A 797 −26.806 13.430 −42.260 1.00 66.95 C ATOM 5718 ND1 HIS A 797 −27.515 14.210 −41.376 1.00 68.45 N ATOM 5719 CE1 HIS A 797 −27.964 15.282 −42.002 1.00 73.46 C ATOM 5720 NE2 HIS A 797 −27.548 15.238 −43.254 1.00 75.02 N ATOM 5721 CD2 HIS A 797 −26.815 14.089 −43.440 1.00 72.22 C ATOM 5722 C HIS A 797 −24.224 11.028 −40.907 1.00 61.00 C ATOM 5723 O HIS A 797 −24.380 10.504 −39.813 1.00 62.71 O ATOM 5724 N THR A 798 −23.527 10.488 −41.898 1.00 62.08 N ATOM 5725 CA THR A 798 −23.019 9.108 −41.852 1.00 60.92 C ATOM 5726 CB THR A 798 −23.367 8.360 −43.156 1.00 62.43 C ATOM 5727 OG1 THR A 798 −22.286 8.431 −44.097 1.00 65.22 O ATOM 5728 CG2 THR A 798 −24.612 8.952 −43.828 1.00 65.14 C ATOM 5729 C THR A 798 −21.499 9.000 −41.621 1.00 59.25 C ATOM 5730 O THR A 798 −21.048 7.928 −41.341 1.00 58.16 O ATOM 5731 N PHE A 799 −20.717 10.085 −41.784 1.00 57.94 N ATOM 5732 CA PHE A 799 −19.241 10.069 −41.685 1.00 54.55 C ATOM 5733 CB PHE A 799 −18.767 10.003 −40.202 1.00 56.68 C ATOM 5734 CG PHE A 799 −19.213 11.192 −39.406 1.00 57.35 C ATOM 5735 CD1 PHE A 799 −20.486 11.222 −38.836 1.00 57.85 C ATOM 5736 CE1 PHE A 799 −20.932 12.337 −38.171 1.00 55.63 C ATOM 5737 CZ PHE A 799 −20.118 13.459 −38.090 1.00 56.96 C ATOM 5738 CE2 PHE A 799 −18.865 13.461 −38.665 1.00 57.37 C ATOM 5739 CD2 PHE A 799 −18.418 12.326 −39.323 1.00 58.29 C ATOM 5740 C PHE A 799 −18.600 9.007 −42.558 1.00 54.26 C ATOM 5741 O PHE A 799 −17.567 8.425 −42.220 1.00 51.07 O ATOM 5742 N GLU A 800 −19.211 8.777 −43.712 1.00 60.23 N ATOM 5743 CA GLU A 800 −18.556 8.009 −44.764 1.00 68.41 C ATOM 5744 CB GLU A 800 −19.555 7.411 −45.789 1.00 80.31 C ATOM 5745 CG GLU A 800 −19.603 5.863 −45.900 1.00 88.45 C ATOM 5746 CD GLU A 800 −19.614 5.377 −47.370 1.00 90.36 C ATOM 5747 OE1 GLU A 800 −20.289 6.037 −48.200 1.00 86.61 O ATOM 5748 OE2 GLU A 800 −18.935 4.359 −47.707 1.00 85.42 O ATOM 5749 C GLU A 800 −17.553 8.935 −45.464 1.00 62.73 C ATOM 5750 O GLU A 800 −17.834 10.105 −45.760 1.00 58.09 O ATOM 5751 N VAL A 801 −16.369 8.402 −45.700 1.00 58.01 N ATOM 5752 CA VAL A 801 −15.394 9.096 −46.499 1.00 54.54 C ATOM 5753 CB VAL A 801 −14.007 8.437 −46.352 1.00 52.29 C ATOM 5754 CG1 VAL A 801 −12.972 9.223 −47.109 1.00 52.85 C ATOM 5755 CG2 VAL A 801 −13.587 8.343 −44.894 1.00 51.15 C ATOM 5756 C VAL A 801 −15.939 9.006 −47.944 1.00 56.13 C ATOM 5757 O VAL A 801 −15.950 7.922 −48.565 1.00 60.10 O ATOM 5758 N LEU A 802 −16.444 10.129 −48.449 1.00 54.98 N ATOM 5759 CA LEU A 802 −16.978 10.195 −49.800 1.00 54.94 C ATOM 5760 CB LEU A 802 −17.966 11.345 −49.940 1.00 54.17 C ATOM 5761 CG LEU A 802 −19.078 11.454 −48.888 1.00 55.94 C ATOM 5762 CD1 LEU A 802 −20.185 12.450 −49.248 1.00 56.09 C ATOM 5763 CD2 LEU A 802 −19.697 10.105 −48.588 1.00 56.99 C ATOM 5764 C LEU A 802 −15.871 10.339 −50.838 1.00 59.61 C ATOM 5765 O LEU A 802 −15.995 9.779 −51.913 1.00 64.08 O ATOM 5766 N HIS A 803 −14.811 11.100 −50.544 1.00 62.83 N ATOM 5767 CA HIS A 803 −13.700 11.321 −51.513 1.00 64.37 C ATOM 5768 CB HIS A 803 −14.055 12.500 −52.427 1.00 67.66 C ATOM 5769 CG HIS A 803 −13.112 12.729 −53.568 1.00 69.85 C ATOM 5770 ND1 HIS A 803 −13.495 12.569 −54.880 1.00 71.24 N ATOM 5771 CE1 HIS A 803 −12.480 12.869 −55.673 1.00 72.28 C ATOM 5772 NE2 HIS A 803 −11.464 13.253 −54.925 1.00 73.19 N ATOM 5773 CD2 HIS A 803 −11.838 13.190 −53.604 1.00 72.67 C ATOM 5774 C HIS A 803 −12.410 11.624 −50.768 1.00 60.62 C ATOM 5775 O HIS A 803 −12.456 12.204 −49.706 1.00 59.28 O ATOM 5776 N ALA A 804 −11.277 11.218 −51.324 1.00 57.73 N ATOM 5777 CA ALA A 804 −9.963 11.512 −50.769 1.00 57.73 C ATOM 5778 CB ALA A 804 −9.348 10.245 −50.235 1.00 58.29 C ATOM 5779 C ALA A 804 −9.068 12.084 −51.866 1.00 59.60 C ATOM 5780 O ALA A 804 −8.756 11.399 −52.834 1.00 65.60 O ATOM 5781 N HIS A 805 −8.670 13.339 −51.733 1.00 57.63 N ATOM 5782 CA HIS A 805 −7.807 13.962 −52.715 1.00 56.41 C ATOM 5783 CB HIS A 805 −8.226 15.403 −52.976 1.00 55.50 C ATOM 5784 CG HIS A 805 −7.258 16.148 −53.832 1.00 55.80 C ATOM 5785 ND1 HIS A 805 −7.362 16.186 −55.201 1.00 54.75 N ATOM 5786 CE1 HIS A 805 −6.359 16.887 −55.698 1.00 57.39 C ATOM 5787 NE2 HIS A 805 −5.593 17.286 −54.704 1.00 59.28 N ATOM 5788 CD2 HIS A 805 −6.129 16.827 −53.522 1.00 59.73 C ATOM 5789 C HIS A 805 −6.395 13.937 −52.170 1.00 55.74 C ATOM 5790 O HIS A 805 −6.176 14.451 −51.116 1.00 58.65 O ATOM 5791 N GLN A 806 −5.448 13.374 −52.915 1.00 55.03 N ATOM 5792 CA GLN A 806 −4.044 13.303 −52.528 1.00 53.03 C ATOM 5793 CB GLN A 806 −3.457 12.074 −53.144 1.00 51.59 C ATOM 5794 CG GLN A 806 −2.088 11.736 −52.631 1.00 53.27 C ATOM 5795 CD GLN A 806 −1.782 10.248 −52.812 1.00 56.09 C ATOM 5796 OE1 GLN A 806 −2.481 9.340 −52.278 1.00 55.12 O ATOM 5797 NE2 GLN A 806 −0.738 9.983 −53.571 1.00 55.85 N ATOM 5798 C GLN A 806 −3.260 14.501 −53.042 1.00 56.30 C ATOM 5799 O GLN A 806 −3.296 14.789 −54.233 1.00 62.61 O ATOM 5800 N PHE A 807 −2.548 15.206 −52.169 1.00 54.27 N ATOM 5801 CA PHE A 807 −1.707 16.333 −52.597 1.00 51.89 C ATOM 5802 CB PHE A 807 −1.500 17.286 −51.391 1.00 51.23 C ATOM 5803 CG PHE A 807 −2.764 18.011 −50.990 1.00 49.52 C ATOM 5804 CD1 PHE A 807 −3.151 19.177 −51.645 1.00 48.06 C ATOM 5805 CE1 PHE A 807 −4.339 19.821 −51.336 1.00 46.58 C ATOM 5806 CZ PHE A 807 −5.147 19.321 −50.334 1.00 48.58 C ATOM 5807 CE2 PHE A 807 −4.780 18.162 −49.667 1.00 49.62 C ATOM 5808 CD2 PHE A 807 −3.596 17.503 −50.005 1.00 50.01 C ATOM 5809 C PHE A 807 −0.405 15.792 −53.299 1.00 52.52 C ATOM 5810 O PHE A 807 −0.267 14.584 −53.459 1.00 48.56 O ATOM 5811 N LEU A 808 0.520 16.660 −53.737 1.00 55.32 N ATOM 5812 CA LEU A 808 1.727 16.241 −54.533 1.00 55.66 C ATOM 5813 CB LEU A 808 2.496 17.415 −55.181 1.00 55.50 C ATOM 5814 CG LEU A 808 1.619 18.398 −55.991 1.00 57.35 C ATOM 5815 CD1 LEU A 808 2.229 19.782 −56.170 1.00 54.58 C ATOM 5816 CD2 LEU A 808 1.199 17.808 −57.320 1.00 61.03 C ATOM 5817 C LEU A 808 2.685 15.433 −53.698 1.00 55.47 C ATOM 5818 O LEU A 808 2.459 15.276 −52.494 1.00 55.75 O ATOM 5819 N GLN A 809 3.699 14.853 −54.350 1.00 58.31 N ATOM 5820 CA GLN A 809 4.742 14.089 −53.643 1.00 62.19 C ATOM 5821 CB GLN A 809 5.581 13.157 −54.570 1.00 60.74 C ATOM 5822 C GLN A 809 5.518 15.249 −53.031 1.00 60.46 C ATOM 5823 O GLN A 809 5.634 16.286 −53.692 1.00 61.74 O ATOM 5824 N ASN A 810 5.927 15.106 −51.761 1.00 57.58 N ATOM 5825 CA ASN A 810 6.502 16.189 −50.943 1.00 58.63 C ATOM 5826 CB ASN A 810 7.769 16.794 −51.613 1.00 63.62 C ATOM 5827 CG ASN A 810 8.964 15.875 −51.572 1.00 65.03 C ATOM 5828 OD1 ASN A 810 9.510 15.563 −52.605 1.00 67.62 O ATOM 5829 ND2 ASN A 810 9.393 15.463 −50.379 1.00 70.25 N ATOM 5830 C ASN A 810 5.582 17.369 −50.461 1.00 53.81 C ATOM 5831 O ASN A 810 6.003 18.191 −49.648 1.00 53.95 O ATOM 5832 N GLU A 811 4.362 17.483 −50.935 1.00 51.67 N ATOM 5833 CA GLU A 811 3.492 18.591 −50.516 1.00 52.35 C ATOM 5834 CB GLU A 811 2.426 18.840 −51.584 1.00 51.30 C ATOM 5835 CG GLU A 811 1.505 19.985 −51.256 1.00 54.99 C ATOM 5836 CD GLU A 811 0.629 20.359 −52.424 1.00 56.90 C ATOM 5837 OE1 GLU A 811 0.319 19.432 −53.168 1.00 58.35 O ATOM 5838 OE2 GLU A 811 0.208 21.539 −52.596 1.00 55.53 O ATOM 5839 C GLU A 811 2.859 18.330 −49.110 1.00 52.32 C ATOM 5840 O GLU A 811 2.327 17.241 −48.826 1.00 46.84 O ATOM 5841 N TYR A 812 2.935 19.348 −48.242 1.00 55.42 N ATOM 5842 CA TYR A 812 2.545 19.239 −46.827 1.00 55.12 C ATOM 5843 CB TYR A 812 3.717 19.609 −45.921 1.00 55.19 C ATOM 5844 CG TYR A 812 3.525 19.123 −44.513 1.00 62.10 C ATOM 5845 CD1 TYR A 812 2.579 19.745 −43.667 1.00 67.69 C ATOM 5846 CE1 TYR A 812 2.363 19.313 −42.351 1.00 68.73 C ATOM 5847 CZ TYR A 812 3.103 18.242 −41.856 1.00 68.65 C ATOM 5848 OH TYR A 812 2.840 17.843 −40.561 1.00 63.55 O ATOM 5849 CE2 TYR A 812 4.061 17.594 −42.686 1.00 66.74 C ATOM 5850 CD2 TYR A 812 4.258 18.028 −44.004 1.00 61.76 C ATOM 5851 C TYR A 812 1.386 20.174 −46.625 1.00 53.21 C ATOM 5852 O TYR A 812 1.538 21.377 −46.761 1.00 59.16 O ATOM 5853 N ALA A 813 0.203 19.627 −46.395 1.00 50.39 N ATOM 5854 CA ALA A 813 −1.001 20.458 −46.190 1.00 48.95 C ATOM 5855 CB ALA A 813 −2.288 19.676 −46.411 1.00 48.34 C ATOM 5856 C ALA A 813 −0.992 21.042 −44.798 1.00 47.62 C ATOM 5857 O ALA A 813 −0.871 20.344 −43.800 1.00 45.13 O ATOM 5858 N LEU A 814 −1.120 22.345 −44.758 1.00 47.61 N ATOM 5859 CA LEU A 814 −1.043 23.060 −43.536 1.00 46.14 C ATOM 5860 CB LEU A 814 0.015 24.138 −43.655 1.00 47.82 C ATOM 5861 CG LEU A 814 1.450 23.659 −43.720 1.00 48.19 C ATOM 5862 CD1 LEU A 814 2.390 24.830 −44.004 1.00 49.56 C ATOM 5863 CD2 LEU A 814 1.782 23.007 −42.401 1.00 48.71 C ATOM 5864 C LEU A 814 −2.369 23.659 −43.164 1.00 43.13 C ATOM 5865 O LEU A 814 −2.722 23.544 −42.021 1.00 44.94 O ATOM 5866 N SER A 815 −3.095 24.293 −44.077 1.00 40.62 N ATOM 5867 CA SER A 815 −4.268 25.086 −43.676 1.00 44.24 C ATOM 5868 CB SER A 815 −3.979 26.587 −43.840 1.00 44.65 C ATOM 5869 OG SER A 815 −2.707 26.805 −44.423 1.00 44.65 O ATOM 5870 C SER A 815 −5.527 24.725 −44.440 1.00 47.11 C ATOM 5871 O SER A 815 −5.460 24.279 −45.584 1.00 49.45 O ATOM 5872 N LEU A 816 −6.683 24.920 −43.829 1.00 46.03 N ATOM 5873 CA LEU A 816 −7.903 24.599 −44.533 1.00 45.48 C ATOM 5874 CB LEU A 816 −8.314 23.193 −44.195 1.00 45.49 C ATOM 5875 CG LEU A 816 −9.739 22.844 −44.577 1.00 46.48 C ATOM 5876 CD1 LEU A 816 −9.822 22.382 −46.018 1.00 47.64 C ATOM 5877 CD2 LEU A 816 −10.214 21.734 −43.683 1.00 50.38 C ATOM 5878 C LEU A 816 −8.968 25.555 −44.112 1.00 47.39 C ATOM 5879 O LEU A 816 −9.050 25.880 −42.947 1.00 50.40 O ATOM 5880 N VAL A 817 −9.774 26.010 −45.063 1.00 49.45 N ATOM 5881 CA VAL A 817 −10.987 26.774 −44.779 1.00 52.19 C ATOM 5882 CB VAL A 817 −10.696 28.294 −44.769 1.00 53.45 C ATOM 5883 CG1 VAL A 817 −10.253 28.772 −46.112 1.00 53.48 C ATOM 5884 CG2 VAL A 817 −11.926 29.081 −44.337 1.00 58.84 C ATOM 5885 C VAL A 817 −12.084 26.381 −45.788 1.00 50.57 C ATOM 5886 O VAL A 817 −11.787 25.785 −46.809 1.00 48.41 O ATOM 5887 N SER A 818 −13.341 26.645 −45.463 1.00 50.46 N ATOM 5888 CA SER A 818 −14.433 26.509 −46.407 1.00 51.46 C ATOM 5889 CB SER A 818 −15.363 25.326 −46.058 1.00 52.17 C ATOM 5890 OG SER A 818 −16.761 25.596 −46.385 1.00 51.39 O ATOM 5891 C SER A 818 −15.234 27.792 −46.383 1.00 52.93 C ATOM 5892 O SER A 818 −15.948 28.035 −45.424 1.00 53.61 O ATOM 5893 N CYS A 819 −15.180 28.553 −47.469 1.00 55.91 N ATOM 5894 CA CYS A 819 −15.886 29.816 −47.593 1.00 57.78 C ATOM 5895 CB CYS A 819 −14.969 30.902 −47.073 1.00 58.01 C ATOM 5896 SG CYS A 819 −13.493 31.034 −48.121 1.00 59.61 S ATOM 5897 C CYS A 819 −16.250 30.201 −49.039 1.00 62.91 C ATOM 5898 O CYS A 819 −15.740 29.645 −50.043 1.00 57.87 O ATOM 5899 N LYS A 820 −17.103 31.225 −49.084 1.00 67.80 N ATOM 5900 CA LYS A 820 −17.545 31.930 −50.289 1.00 65.44 C ATOM 5901 CB LYS A 820 −19.010 32.424 −50.097 1.00 65.06 C ATOM 5902 CG LYS A 820 −20.130 31.605 −50.765 1.00 64.54 C ATOM 5903 CD LYS A 820 −21.357 31.232 −49.925 1.00 68.95 C ATOM 5904 CE LYS A 820 −21.779 32.166 −48.787 1.00 74.12 C ATOM 5905 NZ LYS A 820 −22.039 33.544 −49.264 1.00 79.35 N ATOM 5906 C LYS A 820 −16.610 33.128 −50.457 1.00 64.36 C ATOM 5907 O LYS A 820 −16.281 33.787 −49.482 1.00 64.02 O ATOM 5908 N LEU A 821 −16.199 33.419 −51.685 1.00 68.88 N ATOM 5909 CA LEU A 821 −15.368 34.616 −51.957 1.00 68.86 C ATOM 5910 CB LEU A 821 −13.965 34.228 −52.448 1.00 62.41 C ATOM 5911 CG LEU A 821 −13.159 33.310 −51.548 1.00 57.87 C ATOM 5912 CD1 LEU A 821 −11.825 33.017 −52.198 1.00 56.01 C ATOM 5913 CD2 LEU A 821 −12.933 33.950 −50.200 1.00 60.69 C ATOM 5914 C LEU A 821 −16.005 35.525 −52.996 1.00 71.07 C ATOM 5915 O LEU A 821 −16.634 35.044 −53.949 1.00 74.13 O ATOM 5916 N GLY A 822 −15.817 36.828 −52.806 1.00 72.62 N ATOM 5917 CA GLY A 822 −16.322 37.839 −53.729 1.00 77.91 C ATOM 5918 C GLY A 822 −17.753 37.632 −54.215 1.00 77.23 C ATOM 5919 O GLY A 822 −18.614 37.126 −53.488 1.00 72.63 O ATOM 5920 N LYS A 823 −17.987 37.974 −55.477 1.00 79.48 N ATOM 5921 CA LYS A 823 −19.320 37.886 −56.068 1.00 80.02 C ATOM 5922 CB LYS A 823 −19.367 38.702 −57.371 1.00 84.37 C ATOM 5923 CG LYS A 823 −19.142 40.215 −57.190 1.00 86.79 C ATOM 5924 CD LYS A 823 −20.430 40.985 −56.882 1.00 88.01 C ATOM 5925 CE LYS A 823 −20.199 42.192 −55.969 1.00 89.19 C ATOM 5926 NZ LYS A 823 −20.617 43.451 −56.654 1.00 88.35 N ATOM 5927 C LYS A 823 −19.776 36.420 −56.290 1.00 77.26 C ATOM 5928 O LYS A 823 −20.965 36.151 −56.456 1.00 78.42 O ATOM 5929 N ASP A 824 −18.843 35.476 −56.232 1.00 70.81 N ATOM 5930 CA ASP A 824 −19.139 34.072 −56.459 1.00 66.44 C ATOM 5931 CB ASP A 824 −17.846 33.285 −56.413 1.00 65.77 C ATOM 5932 CG ASP A 824 −17.906 32.033 −57.224 1.00 65.45 C ATOM 5933 OD1 ASP A 824 −19.006 31.442 −57.337 1.00 59.97 O ATOM 5934 OD2 ASP A 824 −16.823 31.634 −57.731 1.00 64.15 O ATOM 5935 C ASP A 824 −20.097 33.483 −55.445 1.00 70.87 C ATOM 5936 O ASP A 824 −19.888 33.650 −54.249 1.00 75.82 O ATOM 5937 N PRO A 825 −21.143 32.778 −55.916 1.00 77.62 N ATOM 5938 CA PRO A 825 −22.118 32.126 −55.020 1.00 82.39 C ATOM 5939 CB PRO A 825 −23.360 32.018 −55.913 1.00 81.95 C ATOM 5940 CG PRO A 825 −22.786 31.758 −57.267 1.00 80.20 C ATOM 5941 CD PRO A 825 −21.603 32.691 −57.319 1.00 80.14 C ATOM 5942 C PRO A 825 −21.721 30.717 −54.561 1.00 79.75 C ATOM 5943 O PRO A 825 −22.256 30.205 −53.575 1.00 77.90 O ATOM 5944 N ASN A 826 −20.841 30.089 −55.324 1.00 76.76 N ATOM 5945 CA ASN A 826 −20.296 28.811 −54.964 1.00 77.12 C ATOM 5946 CB ASN A 826 −19.384 28.306 −56.093 1.00 78.14 C ATOM 5947 CG ASN A 826 −20.150 27.688 −57.235 1.00 75.11 C ATOM 5948 OD1 ASN A 826 −21.338 27.389 −57.134 1.00 67.95 O ATOM 5949 ND2 ASN A 826 −19.452 27.452 −58.320 1.00 78.56 N ATOM 5950 C ASN A 826 −19.473 28.897 −53.699 1.00 72.69 C ATOM 5951 O ASN A 826 −18.844 29.941 −53.451 1.00 83.09 O ATOM 5952 N THR A 827 −19.462 27.788 −52.952 1.00 64.96 N ATOM 5953 CA THR A 827 −18.635 27.590 −51.759 1.00 63.56 C ATOM 5954 CB THR A 827 −19.498 27.000 −50.637 1.00 64.72 C ATOM 5955 OG1 THR A 827 −20.703 27.754 −50.471 1.00 60.64 O ATOM 5956 CG2 THR A 827 −18.730 26.976 −49.349 1.00 70.73 C ATOM 5957 C THR A 827 −17.451 26.603 −51.993 1.00 61.56 C ATOM 5958 O THR A 827 −17.635 25.537 −52.501 1.00 64.04 O ATOM 5959 N TYR A 828 −16.244 26.919 −51.569 1.00 62.30 N ATOM 5960 CA TYR A 828 −15.089 26.079 −51.890 1.00 61.63 C ATOM 5961 CB TYR A 828 −14.110 26.884 −52.716 1.00 64.71 C ATOM 5962 CG TYR A 828 −14.714 27.494 −53.931 1.00 64.12 C ATOM 5963 CD1 TYR A 828 −15.342 28.714 −53.849 1.00 66.84 C ATOM 5964 CE1 TYR A 828 −15.912 29.304 −54.958 1.00 74.28 C ATOM 5965 CZ TYR A 828 −15.845 28.658 −56.196 1.00 73.86 C ATOM 5966 OH TYR A 828 −16.415 29.252 −57.312 1.00 68.16 O ATOM 5967 CE2 TYR A 828 −15.200 27.435 −56.296 1.00 70.20 C ATOM 5968 CD2 TYR A 828 −14.643 26.864 −55.162 1.00 66.68 C ATOM 5969 C TYR A 828 −14.391 25.662 −50.614 1.00 61.16 C ATOM 5970 O TYR A 828 −14.582 26.283 −49.591 1.00 64.16 O ATOM 5971 N PHE A 829 −13.629 24.582 −50.669 1.00 57.21 N ATOM 5972 CA PHE A 829 −12.746 24.180 −49.596 1.00 53.13 C ATOM 5973 CB PHE A 829 −12.620 22.644 −49.483 1.00 52.20 C ATOM 5974 CG PHE A 829 −13.793 21.980 −48.839 1.00 48.49 C ATOM 5975 CD1 PHE A 829 −13.924 21.973 −47.475 1.00 48.53 C ATOM 5976 CE1 PHE A 829 −15.008 21.386 −46.857 1.00 48.61 C ATOM 5977 CZ PHE A 829 −15.965 20.766 −47.608 1.00 50.24 C ATOM 5978 CE2 PHE A 829 −15.829 20.747 −48.990 1.00 51.44 C ATOM 5979 CD2 PHE A 829 −14.738 21.359 −49.588 1.00 48.74 C ATOM 5980 C PHE A 829 −11.449 24.723 −50.097 1.00 54.05 C ATOM 5981 O PHE A 829 −11.067 24.392 −51.207 1.00 56.70 O ATOM 5982 N ILE A 830 −10.755 25.547 −49.316 1.00 55.11 N ATOM 5983 CA ILE A 830 −9.413 26.038 −49.727 1.00 54.41 C ATOM 5984 CB ILE A 830 −9.361 27.586 −49.754 1.00 53.78 C ATOM 5985 CG1 ILE A 830 −10.466 28.105 −50.706 1.00 55.17 C ATOM 5986 CD1 ILE A 830 −11.050 29.452 −50.358 1.00 54.32 C ATOM 5987 CG2 ILE A 830 −8.010 28.090 −50.250 1.00 52.31 C ATOM 5988 C ILE A 830 −8.350 25.383 −48.841 1.00 51.19 C ATOM 5989 O ILE A 830 −8.622 25.141 −47.693 1.00 53.19 O ATOM 5990 N VAL A 831 −7.182 25.047 −49.391 1.00 47.40 N ATOM 5991 CA VAL A 831 −6.082 24.491 −48.631 1.00 46.02 C ATOM 5992 CB VAL A 831 −5.814 23.048 −49.055 1.00 46.03 C ATOM 5993 CG1 VAL A 831 −4.636 22.419 −48.280 1.00 45.49 C ATOM 5994 CG2 VAL A 831 −7.077 22.241 −48.881 1.00 47.38 C ATOM 5995 C VAL A 831 −4.819 25.253 −48.928 1.00 47.87 C ATOM 5996 O VAL A 831 −4.464 25.358 −50.070 1.00 57.64 O ATOM 5997 N GLY A 832 −4.114 25.735 −47.917 1.00 47.39 N ATOM 5998 CA GLY A 832 −2.726 26.188 −48.070 1.00 45.76 C ATOM 5999 C GLY A 832 −1.742 25.048 −47.828 1.00 44.54 C ATOM 6000 O GLY A 832 −2.036 24.121 −47.094 1.00 44.64 O ATOM 6001 N THR A 833 −0.562 25.121 −48.411 1.00 44.11 N ATOM 6002 CA THR A 833 0.362 23.996 −48.376 1.00 49.07 C ATOM 6003 CB THR A 833 0.248 23.138 −49.652 1.00 52.08 C ATOM 6004 OG1 THR A 833 0.685 23.914 −50.777 1.00 52.28 O ATOM 6005 CG2 THR A 833 −1.164 22.696 −49.900 1.00 54.14 C ATOM 6006 C THR A 833 1.771 24.511 −48.374 1.00 50.49 C ATOM 6007 O THR A 833 1.961 25.706 −48.427 1.00 57.04 O ATOM 6008 N ALA A 834 2.751 23.612 −48.334 1.00 48.99 N ATOM 6009 CA ALA A 834 4.147 23.961 −48.338 1.00 48.47 C ATOM 6010 CB ALA A 834 4.623 24.160 −46.926 1.00 48.59 C ATOM 6011 C ALA A 834 4.879 22.801 −48.921 1.00 53.72 C ATOM 6012 O ALA A 834 4.431 21.667 −48.814 1.00 58.72 O ATOM 6013 N MET A 835 6.033 23.067 −49.498 1.00 56.20 N ATOM 6014 CA MET A 835 6.817 22.034 −50.115 1.00 56.42 C ATOM 6015 CB MET A 835 7.254 22.462 −51.525 1.00 62.35 C ATOM 6016 CG MET A 835 6.136 22.565 −52.528 1.00 59.23 C ATOM 6017 SD MET A 835 5.548 20.918 −52.885 1.00 60.98 S ATOM 6018 CE MET A 835 3.856 21.426 −53.149 1.00 62.51 C ATOM 6019 C MET A 835 8.040 21.782 −49.272 1.00 54.34 C ATOM 6020 O MET A 835 8.968 22.633 −49.184 1.00 56.84 O ATOM 6021 N VAL A 836 8.072 20.569 −48.758 1.00 49.75 N ATOM 6022 CA VAL A 836 9.029 20.173 −47.791 1.00 52.32 C ATOM 6023 CB VAL A 836 8.320 19.431 −46.650 1.00 53.34 C ATOM 6024 CG1 VAL A 836 9.300 19.098 −45.517 1.00 52.56 C ATOM 6025 CG2 VAL A 836 7.148 20.269 −46.177 1.00 54.57 C ATOM 6026 C VAL A 836 9.986 19.204 −48.396 1.00 53.38 C ATOM 6027 O VAL A 836 9.576 18.140 −48.829 1.00 53.62 O ATOM 6028 N TYR A 837 11.262 19.555 −48.381 1.00 57.58 N ATOM 6029 CA TYR A 837 12.318 18.660 −48.835 1.00 62.07 C ATOM 6030 CB TYR A 837 13.029 19.215 −50.080 1.00 63.18 C ATOM 6031 CG TYR A 837 12.093 19.555 −51.236 1.00 62.94 C ATOM 6032 CD1 TYR A 837 11.491 18.548 −51.995 1.00 62.78 C ATOM 6033 CE1 TYR A 837 10.641 18.863 −53.036 1.00 63.59 C ATOM 6034 CZ TYR A 837 10.373 20.187 −53.314 1.00 63.91 C ATOM 6035 OH TYR A 837 9.529 20.498 −54.337 1.00 70.94 O ATOM 6036 CE2 TYR A 837 10.934 21.197 −52.573 1.00 60.70 C ATOM 6037 CD2 TYR A 837 11.790 20.880 −51.546 1.00 60.19 C ATOM 6038 C TYR A 837 13.312 18.538 −47.709 1.00 65.60 C ATOM 6039 O TYR A 837 13.631 19.531 −47.090 1.00 68.40 O ATOM 6040 N PRO A 838 13.814 17.328 −47.439 1.00 73.08 N ATOM 6041 CA PRO A 838 14.813 17.181 −46.377 1.00 77.35 C ATOM 6042 CB PRO A 838 15.124 15.683 −46.364 1.00 76.77 C ATOM 6043 CG PRO A 838 14.216 15.034 −47.345 1.00 75.70 C ATOM 6044 CD PRO A 838 13.290 16.038 −47.919 1.00 75.12 C ATOM 6045 C PRO A 838 16.114 17.996 −46.552 1.00 84.56 C ATOM 6046 O PRO A 838 16.770 18.264 −45.550 1.00 91.64 O ATOM 6047 N GLU A 839 16.477 18.387 −47.778 1.00 88.27 N ATOM 6048 CA GLU A 839 17.608 19.319 −47.996 1.00 93.59 C ATOM 6049 CB GLU A 839 17.969 19.490 −49.499 1.00 99.76 C ATOM 6050 CG GLU A 839 18.031 18.231 −50.363 1.00 106.49 C ATOM 6051 CD GLU A 839 16.802 18.041 −51.252 1.00 109.63 C ATOM 6052 OE1 GLU A 839 15.886 17.290 −50.835 1.00 108.62 O ATOM 6053 OE2 GLU A 839 16.751 18.644 −52.353 1.00 108.06 O ATOM 6054 C GLU A 839 17.342 20.736 −47.431 1.00 89.95 C ATOM 6055 O GLU A 839 18.285 21.412 −47.029 1.00 90.63 O ATOM 6056 N GLU A 840 16.065 21.150 −47.413 1.00 84.95 N ATOM 6057 CA GLU A 840 15.614 22.546 −47.337 1.00 80.04 C ATOM 6058 CB GLU A 840 14.552 22.762 −48.442 1.00 86.66 C ATOM 6059 CG GLU A 840 14.121 24.192 −48.783 1.00 94.07 C ATOM 6060 CD GLU A 840 12.870 24.235 −49.692 1.00 106.67 C ATOM 6061 OE1 GLU A 840 11.774 23.710 −49.326 1.00 110.19 O ATOM 6062 OE2 GLU A 840 12.969 24.804 −50.804 1.00 119.58 O ATOM 6063 C GLU A 840 15.011 22.818 −45.958 1.00 72.45 C ATOM 6064 O GLU A 840 14.036 22.161 −45.560 1.00 76.87 O ATOM 6065 N ALA A 841 15.577 23.781 −45.229 1.00 64.83 N ATOM 6066 CA ALA A 841 15.090 24.110 −43.894 1.00 59.64 C ATOM 6067 CB ALA A 841 16.157 24.811 −43.074 1.00 57.24 C ATOM 6068 C ALA A 841 13.790 24.905 −43.957 1.00 59.20 C ATOM 6069 O ALA A 841 12.752 24.343 −43.690 1.00 61.55 O ATOM 6070 N GLU A 842 13.840 26.186 −44.322 1.00 64.03 N ATOM 6071 CA GLU A 842 12.631 27.048 −44.457 1.00 67.24 C ATOM 6072 CB GLU A 842 12.938 28.567 −44.319 1.00 73.55 C ATOM 6073 CG GLU A 842 12.748 29.224 −42.933 1.00 81.42 C ATOM 6074 CD GLU A 842 13.995 30.018 −42.470 1.00 93.08 C ATOM 6075 OE1 GLU A 842 14.843 30.330 −43.376 1.00 83.43 O ATOM 6076 OE2 GLU A 842 14.139 30.305 −41.214 1.00 91.85 O ATOM 6077 C GLU A 842 12.065 26.783 −45.846 1.00 63.82 C ATOM 6078 O GLU A 842 12.768 26.898 −46.839 1.00 62.48 O ATOM 6079 N PRO A 843 10.808 26.411 −45.932 1.00 63.20 N ATOM 6080 CA PRO A 843 10.289 26.144 −47.235 1.00 66.49 C ATOM 6081 CB PRO A 843 8.921 25.514 −46.949 1.00 72.95 C ATOM 6082 CG PRO A 843 8.626 25.779 −45.543 1.00 69.76 C ATOM 6083 CD PRO A 843 9.964 25.827 −44.898 1.00 69.06 C ATOM 6084 C PRO A 843 10.141 27.370 −48.102 1.00 66.00 C ATOM 6085 O PRO A 843 9.668 28.407 −47.648 1.00 64.67 O ATOM 6086 N LYS A 844 10.556 27.210 −49.352 1.00 71.43 N ATOM 6087 CA LYS A 844 10.646 28.294 −50.326 1.00 69.50 C ATOM 6088 CB LYS A 844 11.826 28.084 −51.313 1.00 74.57 C ATOM 6089 CG LYS A 844 13.222 27.866 −50.701 1.00 80.42 C ATOM 6090 CD LYS A 844 13.671 28.998 −49.771 1.00 85.88 C ATOM 6091 CE LYS A 844 15.193 29.250 −49.825 1.00 90.87 C ATOM 6092 NZ LYS A 844 15.666 30.198 −50.906 1.00 86.83 N ATOM 6093 C LYS A 844 9.358 28.349 −51.114 1.00 65.88 C ATOM 6094 O LYS A 844 9.048 29.393 −51.627 1.00 63.48 O ATOM 6095 N GLN A 845 8.609 27.242 −51.224 1.00 64.81 N ATOM 6096 CA GLN A 845 7.444 27.206 −52.120 1.00 60.37 C ATOM 6097 CB GLN A 845 7.841 26.709 −53.509 1.00 65.31 C ATOM 6098 CG GLN A 845 9.095 25.839 −53.527 1.00 72.60 C ATOM 6099 CD GLN A 845 9.213 24.945 −54.748 1.00 72.65 C ATOM 6100 OE1 GLN A 845 8.638 25.226 −55.804 1.00 68.27 O ATOM 6101 NE2 GLN A 845 9.955 23.842 −54.592 1.00 71.48 N ATOM 6102 C GLN A 845 6.283 26.396 −51.565 1.00 54.73 C ATOM 6103 O GLN A 845 6.494 25.481 −50.784 1.00 56.90 O ATOM 6104 N GLY A 846 5.075 26.794 −51.963 1.00 48.36 N ATOM 6105 CA GLY A 846 3.819 26.190 −51.567 1.00 47.28 C ATOM 6106 C GLY A 846 2.656 26.606 −52.473 1.00 47.35 C ATOM 6107 O GLY A 846 2.862 27.178 −53.525 1.00 48.22 O ATOM 6108 N ARG A 847 1.424 26.304 −52.081 1.00 49.03 N ATOM 6109 CA ARG A 847 0.241 26.539 −52.933 1.00 50.61 C ATOM 6110 CB ARG A 847 −0.184 25.301 −53.739 1.00 54.50 C ATOM 6111 CG ARG A 847 0.866 24.646 −54.639 1.00 57.00 C ATOM 6112 CD ARG A 847 0.185 23.695 −55.637 1.00 57.62 C ATOM 6113 NE ARG A 847 −0.340 22.454 −55.056 1.00 57.63 N ATOM 6114 CZ ARG A 847 −1.318 21.714 −55.583 1.00 59.05 C ATOM 6115 NH1 ARG A 847 −1.923 22.070 −56.693 1.00 59.94 N ATOM 6116 NH2 ARG A 847 −1.725 20.605 −54.982 1.00 61.83 N ATOM 6117 C ARG A 847 −0.976 26.875 −52.132 1.00 47.96 C ATOM 6118 O ARG A 847 −1.119 26.478 −50.997 1.00 48.86 O ATOM 6119 N ILE A 848 −1.875 27.576 −52.767 1.00 46.02 N ATOM 6120 CA ILE A 848 −3.153 27.809 −52.221 1.00 47.77 C ATOM 6121 CB ILE A 848 −3.423 29.307 −52.067 1.00 47.91 C ATOM 6122 CG1 ILE A 848 −2.431 29.941 −51.090 1.00 50.62 C ATOM 6123 CD1 ILE A 848 −2.531 31.458 −50.980 1.00 51.96 C ATOM 6124 CG2 ILE A 848 −4.816 29.537 −51.517 1.00 49.93 C ATOM 6125 C ILE A 848 −4.028 27.153 −53.278 1.00 51.61 C ATOM 6126 O ILE A 848 −4.147 27.661 −54.401 1.00 57.21 O ATOM 6127 N VAL A 849 −4.605 26.008 −52.947 1.00 50.17 N ATOM 6128 CA VAL A 849 −5.490 25.340 −53.856 1.00 50.21 C ATOM 6129 CB VAL A 849 −5.299 23.816 −53.838 1.00 49.42 C ATOM 6130 CG1 VAL A 849 −6.240 23.184 −54.860 1.00 49.42 C ATOM 6131 CG2 VAL A 849 −3.863 23.440 −54.156 1.00 49.16 C ATOM 6132 C VAL A 849 −6.919 25.635 −53.465 1.00 53.02 C ATOM 6133 O VAL A 849 −7.297 25.382 −52.307 1.00 56.00 O ATOM 6134 N VAL A 850 −7.720 26.125 −54.426 1.00 52.49 N ATOM 6135 CA VAL A 850 −9.178 26.252 −54.236 1.00 52.40 C ATOM 6136 CB VAL A 850 −9.720 27.503 −54.911 1.00 49.52 C ATOM 6137 CG1 VAL A 850 −11.207 27.658 −54.609 1.00 49.27 C ATOM 6138 CG2 VAL A 850 −8.931 28.714 −54.437 1.00 50.72 C ATOM 6139 C VAL A 850 −9.881 25.047 −54.828 1.00 53.01 C ATOM 6140 O VAL A 850 −9.630 24.740 −55.957 1.00 57.30 O ATOM 6141 N PHE A 851 −10.748 24.385 −54.073 1.00 52.61 N ATOM 6142 CA PHE A 851 −11.442 23.194 −54.531 1.00 52.93 C ATOM 6143 CB PHE A 851 −11.177 21.988 −53.634 1.00 51.48 C ATOM 6144 CG PHE A 851 −9.788 21.408 −53.701 1.00 49.32 C ATOM 6145 CD1 PHE A 851 −9.460 20.471 −54.649 1.00 49.60 C ATOM 6146 CE1 PHE A 851 −8.200 19.874 −54.663 1.00 49.85 C ATOM 6147 CZ PHE A 851 −7.277 20.175 −53.683 1.00 48.30 C ATOM 6148 CE2 PHE A 851 −7.611 21.076 −52.709 1.00 47.80 C ATOM 6149 CD2 PHE A 851 −8.863 21.682 −52.715 1.00 48.11 C ATOM 6150 C PHE A 851 −12.940 23.433 −54.442 1.00 58.15 C ATOM 6151 O PHE A 851 −13.383 24.248 −53.648 1.00 57.92 O ATOM 6152 N GLN A 852 −13.702 22.675 −55.241 1.00 64.84 N ATOM 6153 CA GLN A 852 −15.164 22.610 −55.182 1.00 65.99 C ATOM 6154 CB GLN A 852 −15.773 23.244 −56.414 1.00 68.58 C ATOM 6155 CG GLN A 852 −17.274 23.006 −56.587 1.00 72.74 C ATOM 6156 CD GLN A 852 −17.846 23.858 −57.715 1.00 75.83 C ATOM 6157 OE1 GLN A 852 −17.399 23.759 −58.871 1.00 76.52 O ATOM 6158 NE2 GLN A 852 −18.823 24.719 −57.382 1.00 73.32 N ATOM 6159 C GLN A 852 −15.594 21.159 −55.134 1.00 65.84 C ATOM 6160 O GLN A 852 −15.145 20.339 −55.948 1.00 64.31 O ATOM 6161 N TYR A 853 −16.499 20.851 −54.234 1.00 66.18 N ATOM 6162 CA TYR A 853 −17.007 19.516 −54.150 1.00 65.92 C ATOM 6163 CB TYR A 853 −16.975 19.067 −52.703 1.00 63.43 C ATOM 6164 CG TYR A 853 −17.721 17.813 −52.435 1.00 60.14 C ATOM 6165 CD1 TYR A 853 −17.132 16.590 −52.621 1.00 59.78 C ATOM 6166 CE1 TYR A 853 −17.815 15.433 −52.372 1.00 56.76 C ATOM 6167 CZ TYR A 853 −19.088 15.500 −51.934 1.00 57.64 C ATOM 6168 OH TYR A 853 −19.779 14.358 −51.698 1.00 58.92 O ATOM 6169 CE2 TYR A 853 −19.696 16.699 −51.739 1.00 56.14 C ATOM 6170 CD2 TYR A 853 −19.006 17.850 −51.984 1.00 56.17 C ATOM 6171 C TYR A 853 −18.422 19.638 −54.646 1.00 73.92 C ATOM 6172 O TYR A 853 −19.263 20.197 −53.977 1.00 74.16 O ATOM 6173 N SER A 854 −18.688 19.115 −55.832 1.00 88.11 N ATOM 6174 CA SER A 854 −20.019 19.192 −56.408 1.00 87.53 C ATOM 6175 CB SER A 854 −19.962 20.040 −57.659 1.00 90.85 C ATOM 6176 OG SER A 854 −18.880 19.628 −58.463 1.00 92.17 O ATOM 6177 C SER A 854 −20.505 17.819 −56.779 1.00 85.03 C ATOM 6178 O SER A 854 −21.526 17.340 −56.312 1.00 69.44 O ATOM 6179 N ASP A 855 −19.748 17.175 −57.639 1.00 94.15 N ATOM 6180 CA ASP A 855 −20.068 15.838 −58.046 1.00 100.54 C ATOM 6181 CB ASP A 855 −19.274 15.450 −59.277 1.00 96.40 C ATOM 6182 C ASP A 855 −19.494 15.161 −56.873 1.00 99.28 C ATOM 6183 O ASP A 855 −18.823 15.811 −56.114 1.00 98.17 O ATOM 6184 N GLY A 856 −19.684 13.866 −56.731 1.00 92.68 N ATOM 6185 CA GLY A 856 −19.141 13.179 −55.582 1.00 92.46 C ATOM 6186 C GLY A 856 −17.657 13.449 −55.547 1.00 87.86 C ATOM 6187 O GLY A 856 −17.043 13.380 −54.512 1.00 85.35 O ATOM 6188 N LYS A 857 −17.091 13.752 −56.702 1.00 87.98 N ATOM 6189 CA LYS A 857 −15.683 14.097 −56.832 1.00 87.99 C ATOM 6190 CB LYS A 857 −15.178 13.801 −58.240 1.00 85.29 C ATOM 6191 C LYS A 857 −15.416 15.556 −56.485 1.00 82.20 C ATOM 6192 O LYS A 857 −16.332 16.338 −56.302 1.00 75.17 O ATOM 6193 N LEU A 858 −14.137 15.888 −56.396 1.00 76.05 N ATOM 6194 CA LEU A 858 −13.659 17.212 −56.055 1.00 75.39 C ATOM 6195 CB LEU A 858 −12.644 17.013 −54.946 1.00 76.81 C ATOM 6196 CG LEU A 858 −12.522 17.874 −53.700 1.00 73.97 C ATOM 6197 CD1 LEU A 858 −13.880 18.118 −53.082 1.00 71.82 C ATOM 6198 CD2 LEU A 858 −11.640 17.123 −52.729 1.00 72.00 C ATOM 6199 C LEU A 858 −12.925 17.846 −57.220 1.00 73.06 C ATOM 6200 O LEU A 858 −11.957 17.279 −57.694 1.00 70.59 O ATOM 6201 N GLN A 859 −13.349 19.027 −57.665 1.00 75.13 N ATOM 6202 CA GLN A 859 −12.677 19.711 −58.831 1.00 74.72 C ATOM 6203 CB GLN A 859 −13.613 20.530 −59.770 1.00 83.18 C ATOM 6204 CG GLN A 859 −15.129 20.333 −59.660 1.00 92.52 C ATOM 6205 CD GLN A 859 −15.620 18.961 −60.117 1.00 93.93 C ATOM 6206 OE1 GLN A 859 −16.818 18.668 −60.074 1.00 90.76 O ATOM 6207 NE1 GLN A 859 −14.699 18.125 −60.573 1.00 98.17 N ATOM 6208 C GLN A 859 −11.675 20.694 −58.270 1.00 65.13 C ATOM 6209 O GLN A 859 −12.045 21.500 −57.445 1.00 63.60 O ATOM 6210 N THR A 860 −10.426 20.643 −58.705 1.00 57.38 N ATOM 6211 CA THR A 860 −9.531 21.763 −58.472 1.00 54.43 C ATOM 6212 CB THR A 860 −8.072 21.417 −58.827 1.00 54.29 C ATOM 6213 OG1 THR A 860 −7.534 20.497 −57.855 1.00 57.26 O ATOM 6214 CG2 THR A 860 −7.193 22.670 −58.869 1.00 52.19 C ATOM 6215 C THR A 860 −10.011 22.946 −59.316 1.00 54.53 C ATOM 6216 O THR A 860 −9.909 22.914 −60.511 1.00 61.46 O ATOM 6217 N VAL A 861 −10.549 23.977 −58.682 1.00 55.03 N ATOM 6218 CA VAL A 861 −10.975 25.232 −59.329 1.00 51.72 C ATOM 6219 CB VAL A 861 −12.147 25.852 −58.529 1.00 50.12 C ATOM 6220 CG1 VAL A 861 −12.466 27.279 −58.905 1.00 49.38 C ATOM 6221 CG2 VAL A 861 −13.398 25.023 −58.696 1.00 52.93 C ATOM 6222 C VAL A 861 −9.825 26.252 −59.446 1.00 55.24 C ATOM 6223 O VAL A 861 −9.949 27.178 −60.230 1.00 58.88 O ATOM 6224 N ALA A 862 −8.730 26.136 −58.677 1.00 55.23 N ATOM 6225 CA ALA A 862 −7.580 27.057 −58.872 1.00 55.64 C ATOM 6226 CB ALA A 862 −7.979 28.505 −58.572 1.00 54.74 C ATOM 6227 C ALA A 862 −6.348 26.669 −58.060 1.00 55.53 C ATOM 6228 O ALA A 862 −6.472 26.400 −56.886 1.00 66.00 O ATOM 6229 N GLU A 863 −5.177 26.894 −58.610 1.00 52.34 N ATOM 6230 CA GLU A 863 −3.946 26.726 −57.889 1.00 53.06 C ATOM 6231 CB GLU A 863 −2.963 25.922 −58.701 1.00 54.50 C ATOM 6232 CG GLU A 863 −3.082 24.440 −58.556 1.00 56.60 C ATOM 6233 CD GLU A 863 −2.556 23.717 −59.761 1.00 63.90 C ATOM 6234 OE1 GLU A 863 −1.574 22.981 −59.632 1.00 67.68 O ATOM 6235 OE2 GLU A 863 −3.131 23.883 −60.842 1.00 67.15 O ATOM 6236 C GLU A 863 −3.388 28.129 −57.829 1.00 54.58 C ATOM 6237 O GLU A 863 −3.746 28.939 −58.640 1.00 51.10 O ATOM 6238 N LYS A 864 −2.548 28.436 −56.856 1.00 54.78 N ATOM 6239 CA LYS A 864 −1.880 29.716 −56.781 1.00 57.15 C ATOM 6240 CB LYS A 864 −2.586 30.650 −55.826 1.00 62.58 C ATOM 6241 CG LYS A 864 −2.945 32.006 −56.407 1.00 67.89 C ATOM 6242 CD LYS A 864 −1.754 32.924 −56.559 1.00 76.10 C ATOM 6243 CE LYS A 864 −2.026 34.034 −57.569 1.00 84.91 C ATOM 6244 NZ LYS A 864 −3.353 34.699 −57.433 1.00 86.63 N ATOM 6245 C LYS A 864 −0.556 29.316 −56.212 1.00 57.62 C ATOM 6246 O LYS A 864 −0.537 28.737 −55.165 1.00 56.52 O ATOM 6247 N GLU A 865 0.550 29.598 −56.872 1.00 62.80 N ATOM 6248 CA GLU A 865 1.844 29.217 −56.336 1.00 63.94 C ATOM 6249 CB GLU A 865 2.877 29.067 −57.422 1.00 69.37 C ATOM 6250 CG GLU A 865 4.248 28.791 −56.859 1.00 77.02 C ATOM 6251 CD GLU A 865 5.267 28.507 −57.927 1.00 79.92 C ATOM 6252 OE1 GLU A 865 6.380 28.085 −57.581 1.00 81.59 O ATOM 6253 OE2 GLU A 865 4.955 28.706 −59.111 1.00 77.41 O ATOM 6254 C GLU A 865 2.283 30.262 −55.368 1.00 61.46 C ATOM 6255 O GLU A 865 1.866 31.385 −55.487 1.00 66.70 O ATOM 6256 N VAL A 866 3.116 29.915 −54.403 1.00 55.78 N ATOM 6257 CA VAL A 866 3.557 30.905 −53.438 1.00 53.39 C ATOM 6258 CB VAL A 866 2.648 30.950 −52.246 1.00 51.61 C ATOM 6259 CG1 VAL A 866 3.165 31.984 −51.296 1.00 55.87 C ATOM 6260 CG2 VAL A 866 1.286 31.372 −52.714 1.00 51.77 C ATOM 6261 C VAL A 866 5.009 30.742 −53.081 1.00 51.55 C ATOM 6262 O VAL A 866 5.546 29.672 −53.208 1.00 48.96 O ATOM 6263 N LYS A 867 5.669 31.801 −52.653 1.00 51.96 N ATOM 6264 CA LYS A 867 7.128 31.630 −52.465 1.00 52.27 C ATOM 6265 CB LYS A 867 7.943 32.717 −53.257 1.00 47.81 C ATOM 6266 C LYS A 867 7.397 31.437 −50.915 1.00 54.96 C ATOM 6267 O LYS A 867 8.193 32.153 −50.243 1.00 53.46 O ATOM 6268 N GLY A 868 6.698 30.419 −50.387 1.00 57.45 N ATOM 6269 CA GLY A 868 6.676 30.051 −48.958 1.00 59.10 C ATOM 6270 C GLY A 868 5.536 29.105 −48.506 1.00 60.91 C ATOM 6271 O GLY A 868 4.585 28.796 −49.268 1.00 57.49 O ATOM 6272 N ALA A 869 5.645 28.647 −47.249 1.00 60.43 N ATOM 6273 CA ALA A 869 4.604 27.831 −46.579 1.00 55.70 C ATOM 6274 CB ALA A 869 5.169 27.204 −45.316 1.00 55.68 C ATOM 6275 C ALA A 869 3.389 28.651 −46.203 1.00 51.56 C ATOM 6276 O ALA A 869 3.522 29.696 −45.561 1.00 52.04 O ATOM 6277 N VAL A 870 2.216 28.174 −46.572 1.00 46.63 N ATOM 6278 CA VAL A 870 0.996 28.774 −46.107 1.00 47.33 C ATOM 6279 CB VAL A 870 −0.146 28.602 −47.112 1.00 47.82 C ATOM 6280 CG1 VAL A 870 −1.420 29.244 −46.581 1.00 48.57 C ATOM 6281 CG2 VAL A 870 0.218 29.189 −48.474 1.00 48.70 C ATOM 6282 C VAL A 870 0.616 28.122 −44.775 1.00 51.29 C ATOM 6283 O VAL A 870 −0.055 27.106 −44.735 1.00 51.88 O ATOM 6284 N TYR A 871 1.033 28.724 −43.668 1.00 56.05 N ATOM 6285 CA TYR A 871 0.732 28.204 −42.325 1.00 50.29 C ATOM 6286 CB TYR A 871 1.617 28.871 −41.274 1.00 47.62 C ATOM 6287 CG TYR A 871 3.103 28.584 −41.465 1.00 47.07 C ATOM 6288 CD1 TYR A 871 3.617 27.318 −41.249 1.00 48.93 C ATOM 6289 CE1 TYR A 871 4.983 27.045 −41.409 1.00 47.90 C ATOM 6290 CZ TYR A 871 5.837 28.037 −41.803 1.00 48.00 C ATOM 6291 OH TYR A 871 7.167 27.728 −41.974 1.00 54.27 O ATOM 6292 CE2 TYR A 871 5.358 29.312 −42.028 1.00 45.81 C ATOM 6293 CD2 TYR A 871 4.003 29.582 −41.852 1.00 46.32 C ATOM 6294 C TYR A 871 −0.743 28.385 −41.980 1.00 49.03 C ATOM 6295 O TYR A 871 −1.287 27.507 −41.311 1.00 53.21 O ATOM 6296 N SER A 872 −1.387 29.478 −42.426 1.00 46.04 N ATOM 6297 CA SER A 872 −2.808 29.745 −42.076 1.00 47.46 C ATOM 6298 CB SER A 872 −2.881 30.579 −40.834 1.00 48.51 C ATOM 6299 OG SER A 872 −2.027 30.001 −39.883 1.00 53.48 O ATOM 6300 C SER A 872 −3.583 30.490 −43.090 1.00 48.10 C ATOM 6301 O SER A 872 −2.990 31.074 −43.974 1.00 56.31 O ATOM 6302 N MET A 873 −4.906 30.484 −42.971 1.00 45.90 N ATOM 6303 CA MET A 873 −5.769 31.261 −43.857 1.00 48.41 C ATOM 6304 CB MET A 873 −6.178 30.456 −45.092 1.00 52.38 C ATOM 6305 CG MET A 873 −5.030 29.966 −45.972 1.00 56.65 C ATOM 6306 SD MET A 873 −5.516 29.129 −47.500 1.00 62.98 S ATOM 6307 CE MET A 873 −6.424 27.754 −46.861 1.00 59.46 C ATOM 6308 C MET A 873 −7.021 31.654 −43.124 1.00 49.06 C ATOM 6309 O MET A 873 −7.361 31.038 −42.149 1.00 52.23 O ATOM 6310 N VAL A 874 −7.731 32.672 −43.585 1.00 51.30 N ATOM 6311 CA VAL A 874 −9.045 32.990 −43.011 1.00 52.96 C ATOM 6312 CB VAL A 874 −8.934 33.887 −41.742 1.00 54.82 C ATOM 6313 CG1 VAL A 874 −7.577 34.043 −41.052 1.00 54.52 C ATOM 6314 CG2 VAL A 874 −10.126 34.794 −41.438 1.00 57.56 C ATOM 6315 C VAL A 874 −9.924 33.697 −44.022 1.00 51.25 C ATOM 6316 O VAL A 874 −9.432 34.543 −44.701 1.00 56.09 O ATOM 6317 N GLU A 875 −11.216 33.402 −44.098 1.00 50.11 N ATOM 6318 CA GLU A 875 −12.088 34.272 −44.872 1.00 49.71 C ATOM 6319 CB GLU A 875 −13.487 33.721 −45.028 1.00 51.37 C ATOM 6320 CG GLU A 875 −14.433 34.685 −45.753 1.00 55.49 C ATOM 6321 CD GLU A 875 −15.381 35.478 −44.859 1.00 60.79 C ATOM 6322 OE1 GLU A 875 −15.846 34.944 −43.825 1.00 61.73 O ATOM 6323 OE2 GLU A 875 −15.717 36.638 −45.220 1.00 70.65 O ATOM 6324 C GLU A 875 −12.168 35.620 −44.207 1.00 49.70 C ATOM 6325 O GLU A 875 −12.556 35.724 −43.058 1.00 48.98 O ATOM 6326 N PHE A 876 −11.846 36.647 −44.981 1.00 55.38 N ATOM 6327 CA PHE A 876 −11.737 38.029 −44.516 1.00 59.69 C ATOM 6328 CB PHE A 876 −10.287 38.466 −44.587 1.00 60.66 C ATOM 6329 CG PHE A 876 −10.030 39.749 −43.892 1.00 66.45 C ATOM 6330 CD1 PHE A 876 −10.211 39.845 −42.530 1.00 71.04 C ATOM 6331 CE1 PHE A 876 −9.979 41.040 −41.875 1.00 73.82 C ATOM 6332 CZ PHE A 876 −9.570 42.158 −42.588 1.00 70.95 C ATOM 6333 CE2 PHE A 876 −9.388 42.079 −43.949 1.00 69.82 C ATOM 6334 CD2 PHE A 876 −9.623 40.876 −44.595 1.00 72.32 C ATOM 6335 C PHE A 876 −12.600 38.970 −45.358 1.00 61.16 C ATOM 6336 O PHE A 876 −12.194 39.421 −46.421 1.00 62.24 O ATOM 6337 N ASN A 877 −13.822 39.204 −44.897 1.00 65.52 N ATOM 6338 CA ASN A 877 −14.776 40.125 −45.529 1.00 66.10 C ATOM 6339 CB ASN A 877 −14.322 41.559 −45.288 1.00 67.59 C ATOM 6340 CG ASN A 877 −14.152 41.845 −43.808 1.00 72.11 C ATOM 6341 OD1 ASN A 877 −15.103 41.708 −43.040 1.00 75.81 O ATOM 6342 ND2 ASN A 877 −12.936 42.189 −43.387 1.00 76.33 N ATOM 6343 C ASN A 877 −15.052 39.826 −46.992 1.00 64.55 C ATOM 6344 O ASN A 877 −15.311 40.715 −47.801 1.00 68.13 O ATOM 6345 N GLY A 878 −15.025 38.541 −47.302 1.00 64.36 N ATOM 6346 CA GLY A 878 −15.261 38.055 −48.640 1.00 64.80 C ATOM 6347 C GLY A 878 −14.022 37.936 −49.477 1.00 62.20 C ATOM 6348 O GLY A 878 −14.142 37.577 −50.649 1.00 68.53 O ATOM 6349 N LYS A 879 −12.860 38.242 −48.896 1.00 56.64 N ATOM 6350 CA LYS A 879 −11.562 38.030 −49.523 1.00 58.55 C ATOM 6351 CB LYS A 879 −10.770 39.335 −49.464 1.00 61.26 C ATOM 6352 CG LYS A 879 −11.509 40.503 −50.113 1.00 64.02 C ATOM 6353 CD LYS A 879 −10.780 41.840 −50.015 1.00 65.40 C ATOM 6354 CE LYS A 879 −11.690 42.960 −49.477 1.00 64.60 C ATOM 6355 NZ LYS A 879 −11.043 44.215 −49.924 1.00 66.24 N ATOM 6356 C LYS A 879 −10.833 36.907 −48.800 1.00 57.35 C ATOM 6357 O LYS A 879 −11.333 36.422 −47.827 1.00 63.42 O ATOM 6358 N LEU A 880 −9.655 36.493 −49.250 1.00 55.80 N ATOM 6359 CA LEU A 880 −8.937 35.387 −48.599 1.00 55.13 C ATOM 6360 CB LEU A 880 −8.689 34.227 −49.575 1.00 56.57 C ATOM 6361 CG LEU A 880 −8.075 32.949 −48.970 1.00 60.05 C ATOM 6362 CD1 LEU A 880 −9.183 32.000 −48.577 1.00 63.09 C ATOM 6363 CD2 LEU A 880 −7.128 32.192 −49.887 1.00 60.07 C ATOM 6364 C LEU A 880 −7.619 35.900 −48.058 1.00 53.26 C ATOM 6365 O LEU A 880 −6.754 36.334 −48.818 1.00 53.39 O ATOM 6366 N LEU A 881 −7.479 35.853 −46.740 1.00 50.99 N ATOM 6367 CA LEU A 881 −6.277 36.314 −46.040 1.00 49.27 C ATOM 6368 CB LEU A 881 −6.664 36.893 −44.688 1.00 49.88 C ATOM 6369 CG LEU A 881 −5.558 37.547 −43.878 1.00 51.79 C ATOM 6370 CD1 LEU A 881 −4.962 38.662 −44.711 1.00 54.17 C ATOM 6371 CD2 LEU A 881 −6.064 38.065 −42.535 1.00 51.49 C ATOM 6372 C LEU A 881 −5.459 35.104 −45.800 1.00 49.39 C ATOM 6373 O LEU A 881 −6.023 34.064 −45.554 1.00 53.03 O ATOM 6374 N ALA A 882 −4.143 35.222 −45.832 1.00 49.97 N ATOM 6375 CA ALA A 882 −3.284 34.042 −45.780 1.00 53.49 C ATOM 6376 CB ALA A 882 −3.303 33.321 −47.108 1.00 54.60 C ATOM 6377 C ALA A 882 −1.877 34.374 −45.469 1.00 55.87 C ATOM 6378 O ALA A 882 −1.361 35.346 −45.934 1.00 66.08 O ATOM 6379 N SER A 883 −1.228 33.522 −44.720 1.00 59.95 N ATOM 6380 CA SER A 883 0.114 33.797 −44.285 1.00 62.39 C ATOM 6381 CB SER A 883 0.305 33.503 −42.773 1.00 65.31 C ATOM 6382 OG SER A 883 −0.480 32.411 −42.291 1.00 69.64 O ATOM 6383 C SER A 883 0.985 32.944 −45.155 1.00 59.12 C ATOM 6384 O SER A 883 0.701 31.776 −45.356 1.00 63.60 O ATOM 6385 N ILE A 884 2.078 33.508 −45.622 1.00 55.06 N ATOM 6386 CA ILE A 884 3.044 32.757 −46.374 1.00 55.69 C ATOM 6387 CB ILE A 884 3.106 33.260 −47.803 1.00 51.19 C ATOM 6388 CG1 ILE A 884 1.723 33.234 −48.399 1.00 49.11 C ATOM 6389 CD1 ILE A 884 1.526 34.229 −49.495 1.00 47.80 C ATOM 6390 CG2 ILE A 884 4.019 32.400 −48.632 1.00 49.82 C ATOM 6391 C ILE A 884 4.303 33.150 −45.659 1.00 56.66 C ATOM 6392 O ILE A 884 4.690 34.289 −45.731 1.00 62.91 O ATOM 6393 N ASN A 885 4.933 32.236 −44.951 1.00 53.81 N ATOM 6394 CA ASN A 885 6.135 32.582 −44.228 1.00 59.51 C ATOM 6395 CB ASN A 885 7.312 32.709 −45.148 1.00 65.81 C ATOM 6396 CG ASN A 885 7.696 31.384 −45.726 1.00 79.47 C ATOM 6397 OD1 ASN A 885 6.841 30.554 −45.943 1.00 93.98 O ATOM 6398 ND2 ASN A 885 8.974 31.167 −45.961 1.00 84.91 N ATOM 6399 C ASN A 885 5.903 33.802 −43.371 1.00 57.87 C ATOM 6400 O ASN A 885 4.955 33.839 −42.631 1.00 54.69 O ATOM 6401 N SER A 886 6.751 34.806 −43.479 1.00 56.07 N ATOM 6402 CA SER A 886 6.584 35.998 −42.678 1.00 55.11 C ATOM 6403 CB SER A 886 7.918 36.661 −42.397 1.00 57.05 C ATOM 6404 OG SER A 886 8.202 37.679 −43.322 1.00 60.49 O ATOM 6405 C SER A 886 5.603 36.988 −43.256 1.00 56.85 C ATOM 6406 O SER A 886 5.365 38.011 −42.670 1.00 59.21 O ATOM 6407 N THR A 887 5.045 36.701 −44.415 1.00 55.53 N ATOM 6408 CA THR A 887 4.078 37.625 −45.035 1.00 56.86 C ATOM 6409 CB THR A 887 4.287 37.672 −46.562 1.00 59.91 C ATOM 6410 OG1 THR A 887 5.490 38.381 −46.835 1.00 65.24 O ATOM 6411 CG2 THR A 887 3.169 38.412 −47.278 1.00 61.35 C ATOM 6412 C THR A 887 2.609 37.297 −44.755 1.00 53.06 C ATOM 6413 O THR A 887 2.185 36.166 −44.866 1.00 47.37 O ATOM 6414 N VAL A 888 1.833 38.316 −44.440 1.00 53.58 N ATOM 6415 CA VAL A 888 0.391 38.210 −44.460 1.00 56.33 C ATOM 6416 CB VAL A 888 −0.244 39.005 −43.313 1.00 60.88 C ATOM 6417 CG1 VAL A 888 −1.701 39.283 −43.610 1.00 65.40 C ATOM 6418 CG2 VAL A 888 −0.140 38.242 −41.996 1.00 62.83 C ATOM 6419 C VAL A 888 −0.019 38.847 −45.760 1.00 57.70 C ATOM 6420 O VAL A 888 0.457 39.929 −46.050 1.00 65.46 O ATOM 6421 N ARG A 889 −0.933 38.220 −46.507 1.00 55.82 N ATOM 6422 CA ARG A 889 −1.280 38.620 −47.865 1.00 50.96 C ATOM 6423 CB ARG A 889 −0.488 37.765 −48.843 1.00 52.73 C ATOM 6424 CG ARG A 889 −0.817 38.034 −50.322 1.00 59.02 C ATOM 6425 CD ARG A 889 0.184 37.424 −51.321 1.00 61.53 C ATOM 6426 NE ARG A 889 1.602 37.662 −50.976 1.00 62.63 N ATOM 6427 CZ ARG A 889 2.651 36.959 −51.438 1.00 60.72 C ATOM 6428 NH1 ARG A 889 2.519 35.944 −52.309 1.00 61.51 N ATOM 6429 NH2 ARG A 889 3.862 37.281 −51.020 1.00 59.26 N ATOM 6430 C ARG A 889 −2.777 38.485 −48.129 1.00 48.97 C ATOM 6431 O ARG A 889 −3.356 37.452 −47.917 1.00 47.97 O ATOM 6432 N LEU A 890 −3.410 39.529 −48.628 1.00 50.59 N ATOM 6433 CA LEU A 890 −4.834 39.475 −48.947 1.00 50.80 C ATOM 6434 CB LEU A 890 −5.446 40.765 −48.506 1.00 50.30 C ATOM 6435 CG LEU A 890 −6.945 40.880 −48.595 1.00 53.20 C ATOM 6436 CD1 LEU A 890 −7.708 39.698 −48.058 1.00 53.14 C ATOM 6437 CD2 LEU A 890 −7.310 42.122 −47.802 1.00 57.82 C ATOM 6438 C LEU A 890 −5.055 39.262 −50.455 1.00 52.81 C ATOM 6439 O LEU A 890 −4.321 39.804 −51.258 1.00 50.86 O ATOM 6440 N TYR A 891 −6.035 38.433 −50.826 1.00 53.59 N ATOM 6441 CA TYR A 891 −6.300 38.031 −52.217 1.00 50.49 C ATOM 6442 CB TYR A 891 −6.053 36.498 −52.415 1.00 49.83 C ATOM 6443 CG TYR A 891 −4.606 35.948 −52.373 1.00 51.34 C ATOM 6444 CD1 TYR A 891 −3.753 36.079 −53.476 1.00 56.18 C ATOM 6445 CE1 TYR A 891 −2.449 35.595 −53.467 1.00 55.30 C ATOM 6446 CZ TYR A 891 −1.996 34.937 −52.368 1.00 55.74 C ATOM 6447 OH TYR A 891 −0.714 34.457 −52.406 1.00 58.21 O ATOM 6448 CE2 TYR A 891 −2.819 34.765 −51.267 1.00 53.31 C ATOM 6449 CD2 TYR A 891 −4.113 35.265 −51.275 1.00 50.70 C ATOM 6450 C TYR A 891 −7.781 38.288 −52.444 1.00 51.63 C ATOM 6451 O TYR A 891 −8.569 38.031 −51.512 1.00 48.72 O ATOM 6452 N GLU A 892 −8.175 38.783 −53.634 1.00 51.72 N ATOM 6453 CA GLU A 892 −9.596 38.823 −54.011 1.00 52.55 C ATOM 6454 CB GLU A 892 −9.956 40.141 −54.627 1.00 57.98 C ATOM 6455 CG GLU A 892 −10.188 41.302 −53.671 1.00 62.53 C ATOM 6456 CD GLU A 892 −9.788 42.617 −54.314 1.00 65.85 C ATOM 6457 OE1 GLU A 892 −10.652 43.485 −54.510 1.00 66.66 O ATOM 6458 OE2 GLU A 892 −8.597 42.756 −54.689 1.00 73.68 O ATOM 6459 C GLU A 892 −9.854 37.766 −55.047 1.00 54.43 C ATOM 6460 O GLU A 892 −8.914 37.245 −55.670 1.00 50.96 O ATOM 6461 N TRP A 893 −11.145 37.469 −55.247 1.00 58.70 N ATOM 6462 CA TRP A 893 −11.621 36.357 −56.143 1.00 58.85 C ATOM 6463 CB TRP A 893 −12.653 35.470 −55.371 1.00 55.44 C ATOM 6464 CG TRP A 893 −13.071 34.140 −56.008 1.00 50.44 C ATOM 6465 CD1 TRP A 893 −14.349 33.734 −56.280 1.00 50.69 C ATOM 6466 NE1 TRP A 893 −14.356 32.478 −56.830 1.00 49.69 N ATOM 6467 CE2 TRP A 893 −13.063 32.035 −56.895 1.00 51.01 C ATOM 6468 CD2 TRP A 893 −12.230 33.053 −56.383 1.00 48.03 C ATOM 6469 CE3 TRP A 893 −10.851 32.828 −56.326 1.00 48.95 C ATOM 6470 CZ3 TRP A 893 −10.333 31.599 −56.792 1.00 49.46 C ATOM 6471 CH2 TRP A 893 −11.179 30.624 −57.319 1.00 52.67 C ATOM 6472 CZ2 TRP A 893 −12.551 30.814 −57.368 1.00 53.80 C ATOM 6473 C TRP A 893 −12.217 36.904 −57.460 1.00 60.74 C ATOM 6474 O TRP A 893 −13.374 37.350 −57.484 1.00 55.54 O ATOM 6475 N THR A 894 −11.429 36.827 −58.543 1.00 66.75 N ATOM 6476 CA THR A 894 −11.794 37.413 −59.848 1.00 69.09 C ATOM 6477 CB THR A 894 −10.609 37.471 −60.907 1.00 69.50 C ATOM 6478 OG1 THR A 894 −10.603 36.359 −61.826 1.00 58.67 O ATOM 6479 CG2 THR A 894 −9.199 37.614 −60.262 1.00 71.06 C ATOM 6480 C THR A 894 −12.997 36.623 −60.381 1.00 74.83 C ATOM 6481 O THR A 894 −13.171 35.454 −60.005 1.00 71.50 O ATOM 6482 N THR A 895 −13.836 37.271 −61.212 1.00 81.67 N ATOM 6483 CA THR A 895 −14.958 36.592 −61.942 1.00 80.81 C ATOM 6484 CB THR A 895 −15.990 37.579 −62.589 1.00 83.47 C ATOM 6485 OG1 THR A 895 −15.348 38.819 −62.883 1.00 87.89 O ATOM 6486 CG2 THR A 895 −17.174 37.883 −61.645 1.00 85.65 C ATOM 6487 C THR A 895 −14.419 35.616 −62.993 1.00 73.06 C ATOM 6488 O THR A 895 −15.112 34.661 −63.352 1.00 69.72 O ATOM 6489 N GLU A 896 −13.170 35.845 −63.436 1.00 71.39 N ATOM 6490 CA GLU A 896 −12.370 34.863 −64.205 1.00 67.20 C ATOM 6491 CB GLU A 896 −11.140 35.544 −64.888 1.00 64.67 C ATOM 6492 C GLU A 896 −11.956 33.666 −63.324 1.00 63.20 C ATOM 6493 O GLU A 896 −11.192 32.805 −63.775 1.00 55.50 O ATOM 6494 N LYS A 897 −12.440 33.663 −62.061 1.00 69.66 N ATOM 6495 CA LYS A 897 −12.353 32.568 −61.060 1.00 68.82 C ATOM 6496 CB LYS A 897 −13.034 31.354 −61.641 1.00 70.84 C ATOM 6497 CG LYS A 897 −13.719 30.492 −60.634 1.00 73.40 C ATOM 6498 CD LYS A 897 −14.995 29.875 −61.206 1.00 75.38 C ATOM 6499 CE LYS A 897 −16.174 30.840 −61.118 1.00 74.53 C ATOM 6500 NZ LYS A 897 −17.430 30.052 −60.968 1.00 74.21 N ATOM 6501 C LYS A 897 −10.918 32.258 −60.548 1.00 69.44 C ATOM 6502 O LYS A 897 −10.528 31.090 −60.370 1.00 67.29 O ATOM 6503 N GLU A 898 −10.173 33.341 −60.289 1.00 70.13 N ATOM 6504 CA GLU A 898 −8.736 33.327 −60.000 1.00 73.04 C ATOM 6505 CB GLU A 898 −7.931 33.907 −61.185 1.00 85.84 C ATOM 6506 CG GLU A 898 −7.691 32.999 −62.390 1.00 92.83 C ATOM 6507 CD GLU A 898 −6.603 31.951 −62.154 1.00 101.60 C ATOM 6508 OE1 GLU A 898 −6.872 30.988 −61.387 1.00 107.78 O ATOM 6509 OE2 GLU A 898 −5.497 32.069 −62.754 1.00 100.24 O ATOM 6510 C GLU A 898 −8.439 34.184 −58.767 1.00 68.59 C ATOM 6511 O GLU A 898 −9.219 35.062 −58.378 1.00 66.20 O ATOM 6512 N LEU A 899 −7.287 33.937 −58.168 1.00 63.84 N ATOM 6513 CA LEU A 899 −6.918 34.610 −56.943 1.00 62.96 C ATOM 6514 CB LEU A 899 −6.299 33.635 −55.939 1.00 61.63 C ATOM 6515 CG LEU A 899 −7.263 32.847 −55.067 1.00 59.13 C ATOM 6516 CD1 LEU A 899 −6.507 31.727 −54.362 1.00 59.52 C ATOM 6517 CD2 LEU A 899 −7.982 33.750 −54.069 1.00 57.25 C ATOM 6518 C LEU A 899 −5.913 35.690 −57.243 1.00 64.87 C ATOM 6519 O LEU A 899 −4.747 35.394 −57.552 1.00 63.84 O ATOM 6520 N ARG A 900 −6.368 36.929 −57.101 1.00 65.56 N ATOM 6521 CA ARG A 900 −5.578 38.119 −57.337 1.00 60.24 C ATOM 6522 CB ARG A 900 −6.352 39.062 −58.250 1.00 60.32 C ATOM 6523 CG ARG A 900 −5.750 40.442 −58.386 1.00 60.77 C ATOM 6524 CD ARG A 900 −6.651 41.395 −59.140 1.00 60.35 C ATOM 6525 NE ARG A 900 −7.835 41.752 −58.388 1.00 57.89 N ATOM 6526 CZ ARG A 900 −9.052 41.766 −58.898 1.00 55.32 C ATOM 6527 NH1 ARG A 900 −9.235 41.457 −60.158 1.00 54.21 N ATOM 6528 NH2 ARG A 900 −10.083 42.109 −58.164 1.00 52.17 N ATOM 6529 C ARG A 900 −5.305 38.819 −56.037 1.00 53.84 C ATOM 6530 O ARG A 900 −6.211 39.071 −55.276 1.00 55.74 O ATOM 6531 N THR A 901 −4.043 39.127 −55.809 1.00 45.86 N ATOM 6532 CA THR A 901 −3.562 39.798 −54.626 1.00 45.81 C ATOM 6533 CB THR A 901 −2.064 39.875 −54.727 1.00 44.98 C ATOM 6534 OG1 THR A 901 −1.575 38.619 −55.169 1.00 48.04 O ATOM 6535 CG2 THR A 901 −1.488 40.195 −53.431 1.00 45.13 C ATOM 6536 C THR A 901 −3.975 41.235 −54.463 1.00 45.73 C ATOM 6537 O THR A 901 −4.079 41.950 −55.421 1.00 47.29 O ATOM 6538 N GLU A 902 −4.195 41.672 −53.235 1.00 47.55 N ATOM 6539 CA GLU A 902 −4.529 43.057 −52.998 1.00 47.59 C ATOM 6540 CB GLU A 902 −5.791 43.209 −52.175 1.00 49.43 C ATOM 6541 CG GLU A 902 −6.036 44.632 −51.730 1.00 54.00 C ATOM 6542 CD GLU A 902 −7.441 44.862 −51.255 1.00 60.61 C ATOM 6543 OE1 GLU A 902 −8.275 43.983 −51.440 1.00 61.51 O ATOM 6544 OE2 GLU A 902 −7.727 45.917 −50.687 1.00 67.26 O ATOM 6545 C GLU A 902 −3.389 43.725 −52.282 1.00 47.41 C ATOM 6546 O GLU A 902 −2.849 44.688 −52.753 1.00 53.87 O ATOM 6547 N CYS A 903 −3.006 43.195 −51.141 1.00 50.09 N ATOM 6548 CA CYS A 903 −1.921 43.761 −50.372 1.00 51.56 C ATOM 6549 CB CYS A 903 −2.388 44.776 −49.362 1.00 52.84 C ATOM 6550 SG CYS A 903 −3.980 44.436 −48.688 1.00 59.26 S ATOM 6551 C CYS A 903 −1.090 42.727 −49.704 1.00 50.96 C ATOM 6552 O CYS A 903 −1.393 41.573 −49.725 1.00 49.13 O ATOM 6553 N ASN A 904 0.003 43.168 −49.141 1.00 54.02 N ATOM 6554 CA ASN A 904 0.907 42.290 −48.498 1.00 57.37 C ATOM 6555 CB ASN A 904 2.074 42.129 −49.427 1.00 59.85 C ATOM 6556 CG ASN A 904 2.546 40.729 −49.517 1.00 65.41 C ATOM 6557 OD1 ASN A 904 2.026 39.946 −50.285 1.00 67.49 O ATOM 6558 ND2 ASN A 904 3.546 40.403 −48.744 1.00 69.58 N ATOM 6559 C ASN A 904 1.419 42.967 −47.273 1.00 63.35 C ATOM 6560 O ASN A 904 1.400 44.169 −47.199 1.00 74.58 O ATOM 6561 N HIS A 905 1.867 42.209 −46.293 1.00 64.19 N ATOM 6562 CA HIS A 905 2.471 42.804 −45.129 1.00 62.31 C ATOM 6563 CB HIS A 905 1.526 42.911 −43.984 1.00 61.77 C ATOM 6564 CG HIS A 905 1.856 44.040 −43.081 1.00 64.50 C ATOM 6565 ND1 HIS A 905 3.025 44.089 −42.361 1.00 67.98 N ATOM 6566 CE1 HIS A 905 3.063 45.209 −41.672 1.00 68.31 C ATOM 6567 NE2 HIS A 905 1.968 45.892 −41.931 1.00 67.67 N ATOM 6568 CD2 HIS A 905 1.201 45.187 −42.818 1.00 64.82 C ATOM 6569 C HIS A 905 3.642 41.966 −44.757 1.00 62.12 C ATOM 6570 O HIS A 905 3.499 40.785 −44.606 1.00 66.78 O ATOM 6571 N TYR A 906 4.804 42.561 −44.593 1.00 62.92 N ATOM 6572 CA TYR A 906 5.976 41.770 −44.272 1.00 68.27 C ATOM 6573 CB TYR A 906 7.202 42.241 −45.019 1.00 74.22 C ATOM 6574 CG TYR A 906 6.977 42.308 −46.536 1.00 88.29 C ATOM 6575 CD1 TYR A 906 6.452 43.464 −47.139 1.00 88.05 C ATOM 6576 CE1 TYR A 906 6.255 43.529 −48.512 1.00 90.27 C ATOM 6577 CZ TYR A 906 6.582 42.447 −49.311 1.00 91.26 C ATOM 6578 OH TYR A 906 6.381 42.564 −50.665 1.00 92.72 O ATOM 6579 CE2 TYR A 906 7.094 41.276 −48.757 1.00 90.90 C ATOM 6580 CD2 TYR A 906 7.288 41.206 −47.378 1.00 92.76 C ATOM 6581 C TYR A 906 6.092 41.972 −42.815 1.00 64.66 C ATOM 6582 O TYR A 906 5.714 43.033 −42.341 1.00 63.31 O ATOM 6583 N ASN A 907 6.499 40.934 −42.087 1.00 63.14 N ATOM 6584 CA ASN A 907 6.614 41.043 −40.644 1.00 62.41 C ATOM 6585 CB ASN A 907 5.601 40.176 −39.918 1.00 60.62 C ATOM 6586 CG ASN A 907 4.180 40.558 −40.259 1.00 63.38 C ATOM 6587 OD1 ASN A 907 3.713 41.633 −39.868 1.00 65.25 O ATOM 6588 ND2 ASN A 907 3.485 39.698 −41.024 1.00 65.32 N ATOM 6589 C ASN A 907 7.984 40.651 −40.285 1.00 62.72 C ATOM 6590 O ASN A 907 8.702 40.062 −41.105 1.00 58.53 O ATOM 6591 N ASN A 908 8.337 41.003 −39.055 1.00 66.67 N ATOM 6592 CA ASN A 908 9.598 40.562 −38.450 1.00 74.19 C ATOM 6593 CB ASN A 908 10.298 41.698 −37.624 1.00 80.35 C ATOM 6594 CG ASN A 908 9.319 42.592 −36.855 1.00 83.02 C ATOM 6595 OD1 ASN A 908 8.754 42.199 −35.841 1.00 74.98 O ATOM 6596 ND2 ASN A 908 9.128 43.810 −37.343 1.00 93.04 N ATOM 6597 C ASN A 908 9.374 39.282 −37.624 1.00 72.68 C ATOM 6598 O ASN A 908 10.251 38.859 −36.841 1.00 79.76 O ATOM 6599 N ILE A 909 8.195 38.676 −37.787 1.00 65.24 N ATOM 6600 CA ILE A 909 7.898 37.379 −37.222 1.00 61.27 C ATOM 6601 CB ILE A 909 6.937 37.501 −36.025 1.00 59.32 C ATOM 6602 CG1 ILE A 909 5.593 38.073 −36.450 1.00 62.21 C ATOM 6603 CD1 ILE A 909 4.513 37.831 −35.436 1.00 64.46 C ATOM 6604 CG2 ILE A 909 7.511 38.422 −34.979 1.00 56.06 C ATOM 6605 C ILE A 909 7.307 36.503 −38.321 1.00 60.19 C ATOM 6606 O ILE A 909 7.013 36.964 −39.416 1.00 55.75 O ATOM 6607 N MET A 910 7.107 35.237 −38.001 1.00 60.69 N ATOM 6608 CA MET A 910 6.603 34.276 −38.966 1.00 61.94 C ATOM 6609 CB MET A 910 7.366 32.943 −38.771 1.00 65.29 C ATOM 6610 CG MET A 910 6.645 31.631 −39.025 1.00 72.90 C ATOM 6611 SD MET A 910 7.744 30.186 −38.917 1.00 77.13 S ATOM 6612 CE MET A 910 8.620 30.275 −40.506 1.00 83.84 C ATOM 6613 C MET A 910 5.122 34.241 −38.667 1.00 62.01 C ATOM 6614 O MET A 910 4.759 34.043 −37.542 1.00 73.46 O ATOM 6615 N ALA A 911 4.251 34.512 −39.623 1.00 60.87 N ATOM 6616 CA ALA A 911 2.805 34.419 −39.340 1.00 60.69 C ATOM 6617 CB ALA A 911 2.019 35.129 −40.440 1.00 61.51 C ATOM 6618 C ALA A 911 2.273 32.969 −39.148 1.00 56.88 C ATOM 6619 O ALA A 911 1.676 32.410 −40.044 1.00 63.86 O ATOM 6620 N LEU A 912 2.466 32.355 −38.002 1.00 51.31 N ATOM 6621 CA LEU A 912 1.876 31.055 −37.813 1.00 54.90 C ATOM 6622 CB LEU A 912 2.470 30.298 −36.660 1.00 57.97 C ATOM 6623 CG LEU A 912 3.900 29.897 −36.806 1.00 65.96 C ATOM 6624 CD1 LEU A 912 4.144 28.902 −35.685 1.00 70.20 C ATOM 6625 CD2 LEU A 912 4.192 29.293 −38.170 1.00 68.34 C ATOM 6626 C LEU A 912 0.421 31.121 −37.484 1.00 56.14 C ATOM 6627 O LEU A 912 −0.334 30.258 −37.894 1.00 66.03 O ATOM 6628 N TYR A 913 0.033 32.058 −36.647 1.00 50.55 N ATOM 6629 CA TYR A 913 −1.333 32.133 −36.237 1.00 46.51 C ATOM 6630 CB TYR A 913 −1.387 32.258 −34.725 1.00 44.02 C ATOM 6631 CG TYR A 913 −0.691 31.157 −33.995 1.00 40.75 C ATOM 6632 CD1 TYR A 913 −1.249 29.959 −33.874 1.00 38.78 C ATOM 6633 CE1 TYR A 913 −0.645 28.952 −33.143 1.00 40.30 C ATOM 6634 CZ TYR A 913 0.592 29.121 −32.562 1.00 42.09 C ATOM 6635 OH TYR A 913 1.230 28.087 −31.880 1.00 40.03 O ATOM 6636 CE2 TYR A 913 1.177 30.352 −32.660 1.00 43.94 C ATOM 6637 CD2 TYR A 913 0.520 31.364 −33.367 1.00 44.13 C ATOM 6638 C TYR A 913 −1.959 33.334 −36.956 1.00 47.88 C ATOM 6639 O TYR A 913 −1.293 34.304 −37.214 1.00 55.04 O ATOM 6640 N LEU A 914 −3.225 33.245 −37.302 1.00 49.10 N ATOM 6641 CA LEU A 914 −3.964 34.316 −37.939 1.00 54.70 C ATOM 6642 CB LEU A 914 −4.075 34.068 −39.426 1.00 58.67 C ATOM 6643 CG LEU A 914 −3.276 34.832 −40.433 1.00 64.09 C ATOM 6644 CD1 LEU A 914 −3.752 34.361 −41.808 1.00 68.35 C ATOM 6645 CD2 LEU A 914 −3.499 36.317 −40.264 1.00 65.61 C ATOM 6646 C LEU A 914 −5.367 34.204 −37.451 1.00 54.78 C ATOM 6647 O LEU A 914 −5.979 33.171 −37.629 1.00 58.02 O ATOM 6648 N LYS A 915 −5.905 35.242 −36.873 1.00 52.85 N ATOM 6649 CA LYS A 915 −7.286 35.223 −36.519 1.00 51.64 C ATOM 6650 CB LYS A 915 −7.344 34.940 −35.045 1.00 55.39 C ATOM 6651 CG LYS A 915 −6.802 33.584 −34.649 1.00 58.45 C ATOM 6652 CD LYS A 915 −7.718 32.456 −35.156 1.00 63.14 C ATOM 6653 CE LYS A 915 −7.186 31.065 −34.834 1.00 63.03 C ATOM 6654 NZ LYS A 915 −7.535 30.691 −33.423 1.00 66.90 N ATOM 6655 C LYS A 915 −7.800 36.601 −36.857 1.00 50.19 C ATOM 6656 O LYS A 915 −7.012 37.490 −36.980 1.00 51.89 O ATOM 6657 N THR A 916 −9.096 36.786 −37.043 1.00 50.01 N ATOM 6658 CA THR A 916 −9.650 38.103 −37.355 1.00 52.88 C ATOM 6659 CB THR A 916 −9.919 38.341 −38.875 1.00 52.44 C ATOM 6660 OG1 THR A 916 −10.931 37.454 −39.321 1.00 57.44 O ATOM 6661 CG2 THR A 916 −8.701 38.092 −39.691 1.00 51.06 C ATOM 6662 C THR A 916 −10.957 38.351 −36.622 1.00 56.19 C ATOM 6663 O THR A 916 −11.638 37.415 −36.184 1.00 55.43 O ATOM 6664 N LYS A 917 −11.264 39.644 −36.480 1.00 60.57 N ATOM 6665 CA LYS A 917 −12.535 40.136 −35.979 1.00 61.28 C ATOM 6666 CB LYS A 917 −12.552 40.428 −34.458 1.00 59.53 C ATOM 6667 CG LYS A 917 −14.003 40.606 −34.038 1.00 63.94 C ATOM 6668 CD LYS A 917 −14.334 41.143 −32.662 1.00 68.91 C ATOM 6669 CE LYS A 917 −15.871 41.232 −32.575 1.00 75.74 C ATOM 6670 NZ LYS A 917 −16.414 41.739 −31.279 1.00 81.55 N ATOM 6671 C LYS A 917 −12.835 41.391 −36.761 1.00 64.84 C ATOM 6672 O LYS A 917 −12.175 42.420 −36.567 1.00 63.19 O ATOM 6673 N GLY A 918 −13.820 41.300 −37.652 1.00 70.55 N ATOM 6674 CA GLY A 918 −14.176 42.429 −38.503 1.00 71.54 C ATOM 6675 C GLY A 918 −13.006 42.680 −39.433 1.00 72.80 C ATOM 6676 O GLY A 918 −12.492 41.717 −40.058 1.00 73.84 O ATOM 6677 N ASP A 919 −12.576 43.950 −39.477 1.00 70.04 N ATOM 6678 CA ASP A 919 −11.353 44.358 −40.168 1.00 69.93 C ATOM 6679 CB ASP A 919 −11.452 45.818 −40.648 1.00 73.59 C ATOM 6680 CG ASP A 919 −12.310 46.007 −41.921 1.00 77.10 C ATOM 6681 OD1 ASP A 919 −12.790 45.016 −42.535 1.00 72.82 O ATOM 6682 OD2 ASP A 919 −12.494 47.203 −42.302 1.00 81.93 O ATOM 6683 C ASP A 919 −10.062 44.205 −39.331 1.00 69.26 C ATOM 6684 O ASP A 919 −8.984 44.479 −39.880 1.00 61.62 O ATOM 6685 N PHE A 920 −10.150 43.796 −38.036 1.00 73.69 N ATOM 6686 CA PHE A 920 −8.945 43.579 −37.147 1.00 72.44 C ATOM 6687 CB PHE A 920 −9.252 43.703 −35.632 1.00 77.60 C ATOM 6688 CG PHE A 920 −9.588 45.119 −35.167 1.00 99.97 C ATOM 6689 CD1 PHE A 920 −8.606 46.127 −35.116 1.00 106.06 C ATOM 6690 CE1 PHE A 920 −8.919 47.426 −34.693 1.00 104.91 C ATOM 6691 CZ PHE A 920 −10.217 47.743 −34.301 1.00 104.72 C ATOM 6692 CE2 PHE A 920 −11.204 46.770 −34.329 1.00 108.32 C ATOM 6693 CD2 PHE A 920 −10.895 45.462 −34.751 1.00 111.83 C ATOM 6694 C PHE A 920 −8.309 42.208 −37.456 1.00 66.97 C ATOM 6695 O PHE A 920 −9.012 41.231 −37.672 1.00 61.17 O ATOM 6696 N ILE A 921 −6.984 42.153 −37.512 1.00 61.05 N ATOM 6697 CA ILE A 921 −6.269 40.954 −37.860 1.00 56.97 C ATOM 6698 CB ILE A 921 −5.551 41.123 −39.181 1.00 60.08 C ATOM 6699 CG1 ILE A 921 −6.576 41.297 −40.280 1.00 67.84 C ATOM 6700 CD1 ILE A 921 −5.956 41.686 −41.605 1.00 75.47 C ATOM 6701 CG2 ILE A 921 −4.684 39.920 −39.503 1.00 56.91 C ATOM 6702 C ILE A 921 −5.225 40.748 −36.814 1.00 57.18 C ATOM 6703 O ILE A 921 −4.458 41.647 −36.558 1.00 59.53 O ATOM 6704 N LEU A 922 −5.194 39.552 −36.235 1.00 57.28 N ATOM 6705 CA LEU A 922 −4.251 39.153 −35.205 1.00 55.22 C ATOM 6706 CB LEU A 922 −5.021 38.497 −34.060 1.00 56.07 C ATOM 6707 CG LEU A 922 −4.201 37.743 −33.010 1.00 59.51 C ATOM 6708 CD1 LEU A 922 −2.986 38.521 −32.575 1.00 61.52 C ATOM 6709 CD2 LEU A 922 −5.056 37.457 −31.787 1.00 62.40 C ATOM 6710 C LEU A 922 −3.247 38.152 −35.782 1.00 53.46 C ATOM 6711 O LEU A 922 −3.649 37.119 −36.353 1.00 52.00 O ATOM 6712 N VAL A 923 −1.956 38.450 −35.633 1.00 49.17 N ATOM 6713 CA VAL A 923 −0.908 37.535 −36.080 1.00 49.35 C ATOM 6714 CB VAL A 923 0.055 38.168 −37.108 1.00 48.68 C ATOM 6715 CG1 VAL A 923 1.068 37.127 −37.570 1.00 48.17 C ATOM 6716 CG2 VAL A 923 −0.686 38.720 −38.320 1.00 49.54 C ATOM 6717 C VAL A 923 −0.049 37.073 −34.936 1.00 49.90 C ATOM 6718 O VAL A 923 0.309 37.858 −34.100 1.00 51.63 O ATOM 6719 N GLY A 924 0.368 35.815 −34.941 1.00 51.22 N ATOM 6720 CA GLY A 924 1.264 35.323 −33.885 1.00 50.24 C ATOM 6721 C GLY A 924 2.276 34.379 −34.460 1.00 48.41 C ATOM 6722 O GLY A 924 1.952 33.695 −35.441 1.00 44.82 O ATOM 6723 N ASP A 925 3.494 34.401 −33.893 1.00 48.42 N ATOM 6724 CA ASP A 925 4.503 33.352 −34.098 1.00 51.92 C ATOM 6725 CB ASP A 925 5.909 33.932 −34.496 1.00 57.33 C ATOM 6726 CG ASP A 925 6.757 34.468 −33.304 1.00 58.69 C ATOM 6727 OD1 ASP A 925 6.160 34.828 −32.275 1.00 60.93 O ATOM 6728 OD2 ASP A 925 8.021 34.541 −33.401 1.00 55.19 O ATOM 6729 C ASP A 925 4.549 32.413 −32.885 1.00 52.01 C ATOM 6730 O ASP A 925 3.883 32.647 −31.861 1.00 50.91 O ATOM 6731 N LEU A 926 5.345 31.355 −33.014 1.00 51.49 N ATOM 6732 CA LEU A 926 5.426 30.284 −32.008 1.00 50.62 C ATOM 6733 CB LEU A 926 6.238 29.108 −32.564 1.00 52.79 C ATOM 6734 CG LEU A 926 6.373 27.807 −31.763 1.00 53.25 C ATOM 6735 CD1 LEU A 926 5.017 27.111 −31.638 1.00 57.86 C ATOM 6736 CD2 LEU A 926 7.391 26.876 −32.394 1.00 53.11 C ATOM 6737 C LEU A 926 6.110 30.759 −30.752 1.00 50.29 C ATOM 6738 O LEU A 926 6.198 30.059 −29.744 1.00 48.89 O ATOM 6739 N MET A 927 6.625 31.956 −30.794 1.00 50.81 N ATOM 6740 CA MET A 927 7.381 32.402 −29.695 1.00 52.43 C ATOM 6741 CB MET A 927 8.742 32.783 −30.243 1.00 53.16 C ATOM 6742 CG MET A 927 9.843 32.206 −29.418 1.00 54.03 C ATOM 6743 SD MET A 927 11.338 31.887 −30.345 1.00 50.64 S ATOM 6744 CE MET A 927 12.296 31.443 −28.897 1.00 53.80 C ATOM 6745 C MET A 927 6.616 33.507 −28.950 1.00 49.65 C ATOM 6746 O MET A 927 7.207 34.333 −28.271 1.00 47.70 O ATOM 6747 N ARG A 928 5.286 33.493 −29.090 1.00 49.59 N ATOM 6748 CA ARG A 928 4.388 34.327 −28.325 1.00 51.23 C ATOM 6749 CB ARG A 928 4.534 33.950 −26.824 1.00 54.70 C ATOM 6750 CG ARG A 928 4.234 34.936 −25.705 1.00 58.79 C ATOM 6751 CD ARG A 928 2.768 35.021 −25.403 1.00 61.00 C ATOM 6752 NE ARG A 928 2.522 35.548 −24.060 1.00 65.27 N ATOM 6753 CZ ARG A 928 2.453 36.833 −23.710 1.00 64.60 C ATOM 6754 NH1 ARG A 928 2.631 37.834 −24.593 1.00 60.67 N ATOM 6755 NH2 ARG A 928 2.188 37.094 −22.427 1.00 66.73 N ATOM 6756 C ARG A 928 4.544 35.804 −28.682 1.00 50.79 C ATOM 6757 O ARG A 928 3.974 36.648 −28.015 1.00 54.23 O ATOM 6758 N SER A 929 5.259 36.126 −29.769 1.00 50.86 N ATOM 6759 CA SER A 929 5.219 37.480 −30.341 1.00 50.78 C ATOM 6760 CB SER A 929 6.230 37.761 −31.451 1.00 50.37 C ATOM 6761 OG SER A 929 7.324 36.879 −31.460 1.00 55.31 O ATOM 6762 C SER A 929 3.870 37.575 −30.954 1.00 51.91 C ATOM 6763 O SER A 929 3.451 36.640 −31.611 1.00 58.71 O ATOM 6764 N VAL A 930 3.167 38.677 −30.732 1.00 52.81 N ATOM 6765 CA VAL A 930 1.875 38.871 −31.366 1.00 52.03 C ATOM 6766 CB VAL A 930 0.677 38.479 −30.487 1.00 46.42 C ATOM 6767 CG1 VAL A 930 1.124 37.697 −29.278 1.00 45.68 C ATOM 6768 CG2 VAL A 930 −0.119 39.683 −30.066 1.00 46.36 C ATOM 6769 C VAL A 930 1.782 40.296 −31.855 1.00 55.93 C ATOM 6770 O VAL A 930 2.387 41.196 −31.272 1.00 61.03 O ATOM 6771 N LEU A 931 1.009 40.443 −32.929 1.00 56.79 N ATOM 6772 CA LEU A 931 0.830 41.649 −33.701 1.00 55.28 C ATOM 6773 CB LEU A 931 1.401 41.451 −35.077 1.00 55.57 C ATOM 6774 CG LEU A 931 2.724 42.144 −35.210 1.00 59.06 C ATOM 6775 CD1 LEU A 931 3.790 41.367 −34.462 1.00 61.01 C ATOM 6776 CD2 LEU A 931 3.020 42.286 −36.690 1.00 63.32 C ATOM 6777 C LEU A 931 −0.631 41.942 −33.886 1.00 57.65 C ATOM 6778 O LEU A 931 −1.485 41.092 −33.719 1.00 62.29 O ATOM 6779 N LEU A 932 −0.935 43.153 −34.286 1.00 59.79 N ATOM 6780 CA LEU A 932 −2.308 43.505 −34.417 1.00 61.15 C ATOM 6781 CB LEU A 932 −2.780 44.098 −33.100 1.00 65.94 C ATOM 6782 CG LEU A 932 −4.257 44.422 −33.060 1.00 71.78 C ATOM 6783 CD1 LEU A 932 −5.075 43.150 −33.186 1.00 74.04 C ATOM 6784 CD2 LEU A 932 −4.560 45.153 −31.764 1.00 74.17 C ATOM 6785 C LEU A 932 −2.428 44.442 −35.566 1.00 54.97 C ATOM 6786 O LEU A 932 −2.346 45.597 −35.380 1.00 56.08 O ATOM 6787 N LEU A 933 −2.573 43.887 −36.757 1.00 53.78 N ATOM 6788 CA LEU A 933 −2.742 44.617 −37.994 1.00 55.06 C ATOM 6789 CB LEU A 933 −2.270 43.745 −39.138 1.00 54.03 C ATOM 6790 CG LEU A 933 −0.882 43.133 −39.111 1.00 56.58 C ATOM 6791 CD1 LEU A 933 −0.766 42.108 −40.218 1.00 60.26 C ATOM 6792 CD2 LEU A 933 0.182 44.173 −39.333 1.00 60.95 C ATOM 6793 C LEU A 933 −4.218 45.012 −38.275 1.00 58.09 C ATOM 6794 O LEU A 933 −5.144 44.365 −37.785 1.00 61.84 O ATOM 6795 N ALA A 934 −4.416 46.067 −39.070 1.00 57.42 N ATOM 6796 CA ALA A 934 −5.732 46.440 −39.588 1.00 59.78 C ATOM 6797 CB ALA A 934 −6.248 47.680 −38.905 1.00 58.67 C ATOM 6798 C ALA A 934 −5.707 46.690 −41.090 1.00 62.20 C ATOM 6799 O ALA A 934 −4.716 47.167 −41.666 1.00 62.21 O ATOM 6800 N TYR A 935 −6.835 46.388 −41.708 1.00 61.90 N ATOM 6801 CA TYR A 935 −7.032 46.658 −43.097 1.00 60.92 C ATOM 6802 CB TYR A 935 −7.890 45.581 −43.736 1.00 60.76 C ATOM 6803 CG TYR A 935 −8.188 45.803 −45.187 1.00 61.27 C ATOM 6804 CD1 TYR A 935 −7.199 45.691 −46.141 1.00 65.28 C ATOM 6805 CE1 TYR A 935 −7.477 45.870 −47.488 1.00 68.24 C ATOM 6806 CZ TYR A 935 −8.768 46.167 −47.874 1.00 67.35 C ATOM 6807 OH TYR A 935 −9.075 46.362 −49.192 1.00 69.30 O ATOM 6808 CE2 TYR A 935 −9.765 46.271 −46.936 1.00 63.36 C ATOM 6809 CD2 TYR A 935 −9.468 46.091 −45.608 1.00 62.68 C ATOM 6810 C TYR A 935 −7.689 48.009 −43.132 1.00 60.63 C ATOM 6811 O TYR A 935 −8.484 48.366 −42.280 1.00 59.00 O ATOM 6812 N LYS A 936 −7.288 48.772 −44.117 1.00 64.70 N ATOM 6813 CA LYS A 936 −7.707 50.123 −44.275 1.00 69.16 C ATOM 6814 CB LYS A 936 −6.530 51.079 −44.009 1.00 73.80 C ATOM 6815 CG LYS A 936 −6.107 51.195 −42.540 1.00 77.49 C ATOM 6816 CD LYS A 936 −7.273 51.672 −41.658 1.00 84.16 C ATOM 6817 CE LYS A 936 −6.967 51.653 −40.169 1.00 89.81 C ATOM 6818 NZ LYS A 936 −5.903 52.633 −39.844 1.00 95.51 N ATOM 6819 C LYS A 936 −8.223 50.169 −45.706 1.00 69.78 C ATOM 6820 O LYS A 936 −7.454 50.265 −46.663 1.00 66.02 O ATOM 6821 N PRO A 937 −9.540 50.057 −45.867 1.00 71.21 N ATOM 6822 CA PRO A 937 −10.092 49.989 −47.222 1.00 73.53 C ATOM 6823 CB PRO A 937 −11.586 49.756 −46.988 1.00 73.18 C ATOM 6824 CG PRO A 937 −11.720 49.430 −45.529 1.00 70.50 C ATOM 6825 CD PRO A 937 −10.589 50.086 −44.841 1.00 69.63 C ATOM 6826 C PRO A 937 −9.881 51.256 −48.028 1.00 73.87 C ATOM 6827 O PRO A 937 −9.642 51.157 −49.216 1.00 75.16 O ATOM 6828 N MET A 938 −9.981 52.415 −47.367 1.00 78.37 N ATOM 6829 CA MET A 938 −9.657 53.727 −47.959 1.00 81.51 C ATOM 6830 CB MET A 938 −10.013 54.904 −47.016 1.00 83.62 C ATOM 6831 CG MET A 938 −11.485 55.281 −46.912 1.00 86.08 C ATOM 6832 SD MET A 938 −11.797 56.821 −45.979 1.00 97.74 S ATOM 6833 CE MET A 938 −11.357 56.517 −44.255 1.00 94.85 C ATOM 6834 C MET A 938 −8.184 53.885 −48.338 1.00 79.20 C ATOM 6835 O MET A 938 −7.873 54.817 −49.062 1.00 88.01 O ATOM 6836 N GLU A 939 −7.285 53.039 −47.829 1.00 73.71 N ATOM 6837 CA GLU A 939 −5.855 53.140 −48.118 1.00 71.56 C ATOM 6838 CB GLU A 939 −5.114 53.362 −46.790 1.00 80.54 C ATOM 6839 CG GLU A 939 −3.672 53.878 −46.852 1.00 88.10 C ATOM 6840 CD GLU A 939 −2.753 53.145 −45.862 1.00 95.88 C ATOM 6841 OE1 GLU A 939 −2.310 53.787 −44.893 1.00 99.69 O ATOM 6842 OE2 GLU A 939 −2.494 51.919 −46.020 1.00 96.97 O ATOM 6843 C GLU A 939 −5.304 51.923 −48.883 1.00 65.65 C ATOM 6844 O GLU A 939 −4.128 51.904 −49.209 1.00 58.41 O ATOM 6845 N GLY A 940 −6.151 50.924 −49.178 1.00 67.55 N ATOM 6846 CA GLY A 940 −5.757 49.668 −49.857 1.00 67.67 C ATOM 6847 C GLY A 940 −4.698 48.723 −49.267 1.00 68.12 C ATOM 6848 O GLY A 940 −4.364 47.760 −49.910 1.00 73.43 O ATOM 6849 N ASN A 941 −4.185 48.974 −48.064 1.00 68.84 N ATOM 6850 CA ASN A 941 −3.079 48.211 −47.479 1.00 71.70 C ATOM 6851 CB ASN A 941 −1.783 48.991 −47.612 1.00 75.00 C ATOM 6852 CG ASN A 941 −0.587 48.081 −47.802 1.00 83.48 C ATOM 6853 OD1 ASN A 941 −0.281 47.718 −48.927 1.00 88.10 O ATOM 6854 ND2 ASN A 941 0.085 47.683 −46.702 1.00 87.38 N ATOM 6855 C ASN A 941 −3.342 47.940 −46.000 1.00 72.07 C ATOM 6856 O ASN A 941 −4.352 48.387 −45.501 1.00 81.25 O ATOM 6857 N PHE A 942 −2.475 47.189 −45.311 1.00 68.43 N ATOM 6858 CA PHE A 942 −2.547 47.003 −43.844 1.00 65.95 C ATOM 6859 CB PHE A 942 −2.011 45.622 −43.471 1.00 67.86 C ATOM 6860 CG PHE A 942 −2.730 44.493 −44.112 1.00 67.00 C ATOM 6861 CD1 PHE A 942 −4.024 44.180 −43.724 1.00 67.57 C ATOM 6862 CE1 PHE A 942 −4.692 43.124 −44.305 1.00 68.45 C ATOM 6863 CZ PHE A 942 −4.069 42.360 −45.284 1.00 68.94 C ATOM 6864 CE2 PHE A 942 −2.768 42.655 −45.672 1.00 70.04 C ATOM 6865 CD2 PHE A 942 −2.104 43.718 −45.080 1.00 67.97 C ATOM 6866 C PHE A 942 −1.700 48.001 −43.040 1.00 63.61 C ATOM 6867 O PHE A 942 −0.587 48.305 −43.476 1.00 60.58 O ATOM 6868 N GLU A 943 −2.191 48.422 −41.857 1.00 62.40 N ATOM 6869 CA GLU A 943 −1.433 49.237 −40.841 1.00 66.30 C ATOM 6870 CB GLU A 943 −2.295 50.455 −40.436 1.00 71.73 C ATOM 6871 CG GLU A 943 −1.548 51.614 −39.738 1.00 78.47 C ATOM 6872 CD GLU A 943 −2.311 52.319 −38.582 1.00 81.22 C ATOM 6873 OE1 GLU A 943 −3.554 52.469 −38.611 1.00 79.65 O ATOM 6874 OE2 GLU A 943 −1.650 52.748 −37.606 1.00 84.44 O ATOM 6875 C GLU A 943 −1.122 48.446 −39.540 1.00 64.14 C ATOM 6876 O GLU A 943 −2.017 47.788 −39.051 1.00 65.92 O ATOM 6877 N GLU A 944 0.068 48.535 −38.934 1.00 62.32 N ATOM 6878 CA GLU A 944 0.233 48.006 −37.531 1.00 65.54 C ATOM 6879 CB GLU A 944 1.668 48.066 −37.032 1.00 70.50 C ATOM 6880 CG GLU A 944 2.665 47.307 −37.884 1.00 76.50 C ATOM 6881 CD GLU A 944 3.552 46.393 −37.058 1.00 82.95 C ATOM 6882 OE1 GLU A 944 3.640 46.582 −35.794 1.00 73.57 O ATOM 6883 OE2 GLU A 944 4.141 45.473 −37.706 1.00 91.19 O ATOM 6884 C GLU A 944 −0.540 48.809 −36.508 1.00 60.65 C ATOM 6885 O GLU A 944 −0.459 50.021 −36.530 1.00 64.70 O ATOM 6886 N ILE A 945 −1.253 48.157 −35.601 1.00 57.11 N ATOM 6887 CA ILE A 945 −1.982 48.856 −34.522 1.00 57.87 C ATOM 6888 CB ILE A 945 −3.440 48.370 −34.356 1.00 60.81 C ATOM 6889 CG1 ILE A 945 −4.125 48.232 −35.699 1.00 64.60 C ATOM 6890 CD1 ILE A 945 −3.930 49.417 −36.613 1.00 67.81 C ATOM 6891 CG2 ILE A 945 −4.270 49.327 −33.504 1.00 66.21 C ATOM 6892 C ILE A 945 −1.321 48.706 −33.169 1.00 57.86 C ATOM 6893 O ILE A 945 −1.544 49.524 −32.301 1.00 60.34 O ATOM 6894 N ALA A 946 −0.502 47.677 −32.988 1.00 60.88 N ATOM 6895 CA ALA A 946 −0.031 47.260 −31.653 1.00 60.42 C ATOM 6896 CB ALA A 946 −1.184 47.132 −30.663 1.00 58.22 C ATOM 6897 C ALA A 946 0.712 45.942 −31.737 1.00 63.27 C ATOM 6898 O ALA A 946 0.642 45.238 −32.739 1.00 70.57 O ATOM 6899 N ARG A 947 1.415 45.616 −30.664 1.00 65.32 N ATOM 6900 CA ARG A 947 2.311 44.473 −30.632 1.00 63.84 C ATOM 6901 CB ARG A 947 3.472 44.725 −31.600 1.00 63.47 C ATOM 6902 CG ARG A 947 4.878 44.691 −31.024 1.00 69.15 C ATOM 6903 CD ARG A 947 5.940 45.101 −32.042 1.00 74.73 C ATOM 6904 NE ARG A 947 5.518 44.905 −33.445 1.00 80.73 N ATOM 6905 CZ ARG A 947 6.268 44.382 −34.419 1.00 84.24 C ATOM 6906 NH1 ARG A 947 7.520 43.980 −34.207 1.00 91.10 N ATOM 6907 NH2 ARG A 947 5.757 44.268 −35.634 1.00 83.66 N ATOM 6908 C ARG A 947 2.768 44.199 −29.190 1.00 65.56 C ATOM 6909 O ARG A 947 2.702 45.067 −28.316 1.00 68.19 O ATOM 6910 N ASP A 948 3.164 42.963 −28.954 1.00 66.85 N ATOM 6911 CA ASP A 948 3.811 42.547 −27.715 1.00 70.62 C ATOM 6912 CB ASP A 948 2.761 42.073 −26.703 1.00 75.68 C ATOM 6913 CG ASP A 948 3.361 41.574 −25.374 1.00 81.91 C ATOM 6914 OD1 ASP A 948 4.607 41.464 −25.205 1.00 83.82 O ATOM 6915 OD2 ASP A 948 2.537 41.277 −24.480 1.00 83.63 O ATOM 6916 C ASP A 948 4.738 41.419 −28.138 1.00 65.34 C ATOM 6917 O ASP A 948 4.391 40.665 −29.026 1.00 68.40 O ATOM 6918 N PHE A 949 5.943 41.386 −27.593 1.00 60.77 N ATOM 6919 CA PHE A 949 6.895 40.331 −27.834 1.00 61.97 C ATOM 6920 CB PHE A 949 8.130 40.816 −28.598 1.00 62.94 C ATOM 6921 CG PHE A 949 7.954 40.894 −30.118 1.00 68.91 C ATOM 6922 CD1 PHE A 949 6.765 41.397 −30.723 1.00 72.63 C ATOM 6923 CE1 PHE A 949 6.618 41.502 −32.112 1.00 66.94 C ATOM 6924 CZ PHE A 949 7.658 41.121 −32.919 1.00 66.54 C ATOM 6925 CE2 PHE A 949 8.845 40.625 −32.352 1.00 67.62 C ATOM 6926 CD2 PHE A 949 8.998 40.523 −30.968 1.00 67.18 C ATOM 6927 C PHE A 949 7.290 39.898 −26.452 1.00 63.58 C ATOM 6928 O PHE A 949 7.755 40.688 −25.685 1.00 64.89 O ATOM 6929 N ASN A 950 7.075 38.643 −26.117 1.00 69.68 N ATOM 6930 CA ASN A 950 7.479 38.156 −24.816 1.00 70.55 C ATOM 6931 CB ASN A 950 6.407 38.502 −23.768 1.00 76.86 C ATOM 6932 CG ASN A 950 6.783 38.030 −22.368 1.00 82.27 C ATOM 6933 OD1 ASN A 950 5.929 37.996 −21.496 1.00 88.47 O ATOM 6934 ND2 ASN A 950 8.054 37.618 −22.159 1.00 80.96 N ATOM 6935 C ASN A 950 7.866 36.644 −24.886 1.00 60.43 C ATOM 6936 O ASN A 950 7.035 35.748 −24.831 1.00 54.54 O ATOM 6937 N PRO A 951 9.144 36.384 −25.024 1.00 50.47 N ATOM 6938 CA PRO A 951 9.597 35.094 −25.425 1.00 53.01 C ATOM 6939 CB PRO A 951 11.106 35.201 −25.185 1.00 52.87 C ATOM 6940 CG PRO A 951 11.395 36.570 −25.551 1.00 49.06 C ATOM 6941 CD PRO A 951 10.172 37.382 −25.257 1.00 47.28 C ATOM 6942 C PRO A 951 9.016 33.903 −24.686 1.00 50.75 C ATOM 6943 O PRO A 951 9.477 33.520 −23.645 1.00 57.04 O ATOM 6944 N ASN A 952 8.044 33.257 −25.261 1.00 52.11 N ATOM 6945 CA ASN A 952 7.650 31.941 −24.737 1.00 51.15 C ATOM 6946 CB ASN A 952 6.643 32.063 −23.580 1.00 47.81 C ATOM 6947 CG ASN A 952 6.874 31.036 −22.512 1.00 47.68 C ATOM 6948 OD1 ASN A 952 7.913 30.408 −22.471 1.00 46.82 O ATOM 6949 ND2 ASN A 952 5.897 30.851 −21.636 1.00 51.43 N ATOM 6950 C ASN A 952 7.066 31.084 −25.825 1.00 49.19 C ATOM 6951 O ASN A 952 6.718 31.553 −26.910 1.00 48.56 O ATOM 6952 N TRP A 953 6.948 29.815 −25.524 1.00 45.52 N ATOM 6953 CA TRP A 953 6.361 28.945 −26.471 1.00 43.53 C ATOM 6954 CB TRP A 953 6.778 27.539 −26.148 1.00 44.98 C ATOM 6955 CG TRP A 953 8.261 27.304 −26.244 1.00 46.92 C ATOM 6956 CD1 TRP A 953 9.054 26.704 −25.312 1.00 48.67 C ATOM 6957 NE1 TRP A 953 10.340 26.626 −25.769 1.00 53.06 N ATOM 6958 CE2 TRP A 953 10.395 27.189 −27.021 1.00 52.93 C ATOM 6959 CD2 TRP A 953 9.112 27.620 −27.351 1.00 49.04 C ATOM 6960 CE3 TRP A 953 8.912 28.232 −28.589 1.00 46.82 C ATOM 6961 CZ3 TRP A 953 9.948 28.387 −29.419 1.00 46.54 C ATOM 6962 CH2 TRP A 953 11.208 27.970 −29.077 1.00 49.96 C ATOM 6963 CZ2 TRP A 953 11.463 27.366 −27.880 1.00 54.03 C ATOM 6964 C TRP A 953 4.858 29.147 −26.503 1.00 41.66 C ATOM 6965 O TRP A 953 4.199 29.070 −25.483 1.00 40.00 O ATOM 6966 N MET A 954 4.317 29.439 −27.678 1.00 41.33 N ATOM 6967 CA MET A 954 2.885 29.676 −27.806 1.00 42.78 C ATOM 6968 CB MET A 954 2.624 31.058 −28.307 1.00 41.67 C ATOM 6969 CG MET A 954 1.187 31.474 −28.144 1.00 44.57 C ATOM 6970 SD MET A 954 0.872 33.211 −28.575 1.00 47.49 S ATOM 6971 CE MET A 954 0.659 33.079 −30.362 1.00 49.67 C ATOM 6972 C MET A 954 2.288 28.629 −28.750 1.00 44.79 C ATOM 6973 O MET A 954 2.877 28.324 −29.777 1.00 47.30 O ATOM 6974 N SER A 955 1.140 28.053 −28.357 1.00 44.36 N ATOM 6975 CA SER A 955 0.545 26.858 −29.001 1.00 39.53 C ATOM 6976 CB SER A 955 0.392 25.745 −27.995 1.00 37.80 C ATOM 6977 OG SER A 955 −0.616 26.061 −27.089 1.00 36.72 O ATOM 6978 C SER A 955 −0.779 27.094 −29.636 1.00 37.72 C ATOM 6979 O SER A 955 −1.160 26.347 −30.562 1.00 38.88 O ATOM 6980 N ALA A 956 −1.462 28.133 −29.164 1.00 37.14 N ATOM 6981 CA ALA A 956 −2.761 28.554 −29.708 1.00 39.95 C ATOM 6982 CB ALA A 956 −3.818 27.624 −29.171 1.00 40.49 C ATOM 6983 C ALA A 956 −3.128 30.005 −29.328 1.00 39.17 C ATOM 6984 O ALA A 956 −2.757 30.425 −28.270 1.00 38.60 O ATOM 6985 N VAL A 957 −3.852 30.739 −30.187 1.00 40.09 N ATOM 6986 CA VAL A 957 −4.393 32.073 −29.857 1.00 40.71 C ATOM 6987 CB VAL A 957 −3.565 33.235 −30.387 1.00 41.98 C ATOM 6988 CG1 VAL A 957 −2.506 33.583 −29.378 1.00 45.03 C ATOM 6989 CG2 VAL A 957 −2.939 32.911 −31.725 1.00 42.67 C ATOM 6990 C VAL A 957 −5.756 32.327 −30.390 1.00 41.92 C ATOM 6991 O VAL A 957 −6.098 31.835 −31.392 1.00 43.35 O ATOM 6992 N GLU A 958 −6.524 33.145 −29.703 1.00 49.11 N ATOM 6993 CA GLU A 958 −7.860 33.503 −30.130 1.00 51.25 C ATOM 6994 CB GLU A 958 −8.842 32.654 −29.345 1.00 55.02 C ATOM 6995 CG GLU A 958 −10.256 32.772 −29.868 1.00 57.92 C ATOM 6996 CD GLU A 958 −10.284 32.503 −31.338 1.00 60.78 C ATOM 6997 OE1 GLU A 958 −10.635 33.470 −32.042 1.00 63.49 O ATOM 6998 OE2 GLU A 958 −9.865 31.373 −31.760 1.00 60.98 O ATOM 6999 C GLU A 958 −8.177 34.975 −29.875 1.00 50.41 C ATOM 7000 O GLU A 958 −7.635 35.575 −28.936 1.00 50.08 O ATOM 7001 N ILE A 959 −9.070 35.543 −30.682 1.00 48.50 N ATOM 7002 CA ILE A 959 −9.601 36.907 −30.434 1.00 47.88 C ATOM 7003 CB ILE A 959 −9.906 37.612 −31.772 1.00 47.21 C ATOM 7004 CG1 ILE A 959 −8.584 37.890 −32.519 1.00 49.60 C ATOM 7005 CD1 ILE A 959 −8.735 38.114 −34.020 1.00 49.80 C ATOM 7006 CG2 ILE A 959 −10.757 38.868 −31.596 1.00 46.43 C ATOM 7007 C ILE A 959 −10.858 36.873 −29.562 1.00 48.07 C ATOM 7008 O ILE A 959 −11.908 36.483 −30.051 1.00 51.39 O ATOM 7009 N LEU A 960 −10.766 37.281 −28.295 1.00 46.32 N ATOM 7010 CA LEU A 960 −11.940 37.311 −27.450 1.00 48.81 C ATOM 7011 CB LEU A 960 −11.544 37.461 −26.005 1.00 50.69 C ATOM 7012 CG LEU A 960 −10.962 36.250 −25.269 1.00 53.46 C ATOM 7013 CD1 LEU A 960 −10.104 36.733 −24.122 1.00 55.94 C ATOM 7014 CD2 LEU A 960 −12.047 35.366 −24.688 1.00 54.91 C ATOM 7015 C LEU A 960 −12.901 38.434 −27.840 1.00 53.99 C ATOM 7016 O LEU A 960 −14.091 38.264 −27.744 1.00 56.26 O ATOM 7017 N ASP A 961 −12.375 39.596 −28.222 1.00 63.69 N ATOM 7018 CA ASP A 961 −13.149 40.746 −28.789 1.00 67.90 C ATOM 7019 CB ASP A 961 −14.196 41.329 −27.807 1.00 72.80 C ATOM 7020 CG ASP A 961 −13.593 41.854 −26.514 1.00 72.34 C ATOM 7021 OD1 ASP A 961 −12.414 42.233 −26.487 1.00 71.96 O ATOM 7022 OD2 ASP A 961 −14.329 41.886 −25.512 1.00 76.22 O ATOM 7023 C ASP A 961 −12.174 41.834 −29.307 1.00 69.82 C ATOM 7024 O ASP A 961 −10.939 41.599 −29.308 1.00 63.16 O ATOM 7025 N ASP A 962 −12.693 43.009 −29.712 1.00 73.09 N ATOM 7026 CA ASP A 962 −11.895 43.945 −30.537 1.00 75.97 C ATOM 7027 CB ASP A 962 −12.698 45.181 −30.997 1.00 82.31 C ATOM 7028 CG ASP A 962 −14.024 44.811 −31.739 1.00 87.87 C ATOM 7029 OD1 ASP A 962 −15.038 44.566 −31.030 1.00 84.23 O ATOM 7030 OD2 ASP A 962 −14.053 44.769 −33.012 1.00 89.01 O ATOM 7031 C ASP A 962 −10.649 44.365 −29.788 1.00 73.46 C ATOM 7032 O ASP A 962 −9.635 44.682 −30.434 1.00 73.24 O ATOM 7033 N ASP A 963 −10.744 44.284 −28.443 1.00 71.32 N ATOM 7034 CA ASP A 963 −9.699 44.651 −27.458 1.00 71.36 C ATOM 7035 CB ASP A 963 −10.357 45.422 −26.293 1.00 73.34 C ATOM 7036 CG ASP A 963 −11.254 46.584 −26.754 1.00 74.94 C ATOM 7037 OD1 ASP A 963 −11.056 47.136 −27.862 1.00 74.62 O ATOM 7038 OD2 ASP A 963 −12.156 46.954 −25.974 1.00 72.70 O ATOM 7039 C ASP A 963 −8.843 43.548 −26.770 1.00 69.86 C ATOM 7040 O ASP A 963 −7.747 43.862 −26.277 1.00 66.76 O ATOM 7041 N ASN A 964 −9.340 42.299 −26.672 1.00 69.75 N ATOM 7042 CA ASN A 964 −8.689 41.225 −25.830 1.00 63.76 C ATOM 7043 CB ASN A 964 −9.561 40.856 −24.614 1.00 64.66 C ATOM 7044 CG ASN A 964 −9.768 42.035 −23.676 1.00 68.22 C ATOM 7045 OD1 ASN A 964 −8.898 42.414 −22.896 1.00 62.68 O ATOM 7046 ND2 ASN A 964 −10.915 42.654 −23.796 1.00 76.27 N ATOM 7047 C ASN A 964 −8.329 39.971 −26.582 1.00 55.57 C ATOM 7048 O ASN A 964 −9.088 39.517 −27.398 1.00 55.68 O ATOM 7049 N PHE A 965 −7.168 39.414 −26.285 1.00 53.13 N ATOM 7050 CA PHE A 965 −6.616 38.300 −27.036 1.00 54.46 C ATOM 7051 CB PHE A 965 −5.397 38.769 −27.798 1.00 56.86 C ATOM 7052 CG PHE A 965 −5.687 39.992 −28.581 1.00 65.69 C ATOM 7053 CD1 PHE A 965 −6.683 39.970 −29.556 1.00 72.59 C ATOM 7054 CE1 PHE A 965 −7.025 41.123 −30.269 1.00 77.70 C ATOM 7055 CZ PHE A 965 −6.386 42.332 −29.983 1.00 75.79 C ATOM 7056 CE2 PHE A 965 −5.414 42.368 −28.990 1.00 73.03 C ATOM 7057 CD2 PHE A 965 −5.083 41.204 −28.285 1.00 72.60 C ATOM 7058 C PHE A 965 −6.258 37.240 −26.062 1.00 55.55 C ATOM 7059 O PHE A 965 −5.491 37.488 −25.164 1.00 60.51 O ATOM 7060 N LEU A 966 −6.857 36.063 −26.206 1.00 55.95 N ATOM 7061 CA LEU A 966 −6.526 34.893 −25.375 1.00 48.74 C ATOM 7062 CB LEU A 966 −7.786 34.062 −25.205 1.00 48.75 C ATOM 7063 CG LEU A 966 −7.704 32.738 −24.480 1.00 49.60 C ATOM 7064 CD1 LEU A 966 −7.078 32.908 −23.116 1.00 51.87 C ATOM 7065 CD2 LEU A 966 −9.099 32.174 −24.364 1.00 48.71 C ATOM 7066 C LEU A 966 −5.408 34.098 −26.067 1.00 44.29 C ATOM 7067 O LEU A 966 −5.366 33.975 −27.291 1.00 36.82 O ATOM 7068 N GLY A 967 −4.460 33.616 −25.287 1.00 42.44 N ATOM 7069 CA GLY A 967 −3.434 32.745 −25.833 1.00 41.01 C ATOM 7070 C GLY A 967 −3.072 31.671 −24.851 1.00 40.76 C ATOM 7071 O GLY A 967 −3.388 31.810 −23.663 1.00 41.53 O ATOM 7072 N ALA A 968 −2.450 30.592 −25.354 1.00 40.25 N ATOM 7073 CA ALA A 968 −1.986 29.450 −24.538 1.00 38.27 C ATOM 7074 CB ALA A 968 −2.667 28.181 −24.970 1.00 37.41 C ATOM 7075 C ALA A 968 −0.483 29.339 −24.691 1.00 38.88 C ATOM 7076 O ALA A 968 0.035 29.490 −25.774 1.00 36.11 O ATOM 7077 N GLU A 969 0.227 29.134 −23.590 1.00 43.01 N ATOM 7078 CA GLU A 969 1.675 29.362 −23.577 1.00 45.84 C ATOM 7079 CB GLU A 969 2.006 30.854 −23.360 1.00 48.58 C ATOM 7080 CG GLU A 969 2.262 31.344 −21.929 1.00 50.15 C ATOM 7081 CD GLU A 969 2.809 32.787 −21.875 1.00 56.07 C ATOM 7082 OE1 GLU A 969 4.028 32.971 −22.196 1.00 56.27 O ATOM 7083 OE2 GLU A 969 2.048 33.749 −21.494 1.00 58.91 O ATOM 7084 C GLU A 969 2.336 28.508 −22.550 1.00 47.76 C ATOM 7085 O GLU A 969 1.663 27.934 −21.715 1.00 54.41 O ATOM 7086 N ASN A 970 3.658 28.465 −22.598 1.00 50.69 N ATOM 7087 CA ASN A 970 4.439 27.333 −22.090 1.00 54.96 C ATOM 7088 CB ASN A 970 5.882 27.365 −22.606 1.00 55.19 C ATOM 7089 CG ASN A 970 6.864 26.610 −21.701 1.00 57.35 C ATOM 7090 OD1 ASN A 970 6.876 25.349 −21.677 1.00 51.19 O ATOM 7091 ND2 ASN A 970 7.693 27.374 −20.942 1.00 58.78 N ATOM 7092 C ASN A 970 4.441 27.082 −20.571 1.00 58.63 C ATOM 7093 O ASN A 970 4.507 28.019 −19.768 1.00 54.08 O ATOM 7094 N ALA A 971 4.497 25.760 −20.283 1.00 62.70 N ATOM 7095 CA ALA A 971 4.017 25.048 −19.106 1.00 54.62 C ATOM 7096 CB ALA A 971 4.773 25.463 −17.887 1.00 57.27 C ATOM 7097 C ALA A 971 2.536 25.299 −18.973 1.00 50.39 C ATOM 7098 O ALA A 971 2.082 25.947 −18.050 1.00 54.44 O ATOM 7099 N PHE A 972 1.779 24.863 −19.957 1.00 44.67 N ATOM 7100 CA PHE A 972 0.341 24.718 −19.759 1.00 43.74 C ATOM 7101 CB PHE A 972 0.114 23.533 −18.801 1.00 42.83 C ATOM 7102 CG PHE A 972 1.024 22.403 −19.103 1.00 43.63 C ATOM 7103 CD1 PHE A 972 0.765 21.556 −20.232 1.00 43.25 C ATOM 7104 CE1 PHE A 972 1.674 20.560 −20.596 1.00 38.31 C ATOM 7105 CZ PHE A 972 2.806 20.394 −19.840 1.00 36.97 C ATOM 7106 CE2 PHE A 972 3.077 21.227 −18.747 1.00 37.96 C ATOM 7107 CD2 PHE A 972 2.215 22.249 −18.403 1.00 38.86 C ATOM 7108 C PHE A 972 −0.379 25.928 −19.222 1.00 40.74 C ATOM 7109 O PHE A 972 −1.292 25.769 −18.395 1.00 39.63 O ATOM 7110 N ASN A 973 0.018 27.115 −19.657 1.00 38.26 N ATOM 7111 CA ASN A 973 −0.636 28.314 −19.166 1.00 40.12 C ATOM 7112 CB ASN A 973 0.391 29.358 −18.739 1.00 44.33 C ATOM 7113 CG ASN A 973 1.350 28.883 −17.638 1.00 45.80 C ATOM 7114 OD1 ASN A 973 0.949 28.516 −16.511 1.00 45.41 O ATOM 7115 ND2 ASN A 973 2.632 28.971 −17.940 1.00 45.51 N ATOM 7116 C ASN A 973 −1.585 28.973 −20.174 1.00 39.74 C ATOM 7117 O ASN A 973 −1.433 28.841 −21.409 1.00 38.34 O ATOM 7118 N LEU A 974 −2.584 29.673 −19.647 1.00 39.34 N ATOM 7119 CA LEU A 974 −3.331 30.622 −20.471 1.00 40.64 C ATOM 7120 CB LEU A 974 −4.826 30.448 −20.303 1.00 38.81 C ATOM 7121 CG LEU A 974 −5.444 29.095 −20.626 1.00 37.45 C ATOM 7122 CD1 LEU A 974 −6.955 29.169 −20.476 1.00 36.15 C ATOM 7123 CD2 LEU A 974 −5.071 28.706 −22.047 1.00 38.10 C ATOM 7124 C LEU A 974 −2.896 32.039 −20.081 1.00 43.48 C ATOM 7125 O LEU A 974 −2.494 32.289 −18.923 1.00 44.02 O ATOM 7126 N PHE A 975 −2.904 32.940 −21.067 1.00 45.72 N ATOM 7127 CA PHE A 975 −2.530 34.350 −20.863 1.00 46.17 C ATOM 7128 CB PHE A 975 −1.069 34.616 −21.240 1.00 45.99 C ATOM 7129 CG PHE A 975 −0.848 34.639 −22.684 1.00 48.32 C ATOM 7130 CD1 PHE A 975 −1.119 35.795 −23.417 1.00 50.74 C ATOM 7131 CE1 PHE A 975 −0.982 35.806 −24.801 1.00 53.92 C ATOM 7132 CZ PHE A 975 −0.581 34.636 −25.462 1.00 56.41 C ATOM 7133 CE2 PHE A 975 −0.322 33.458 −24.727 1.00 52.61 C ATOM 7134 CD2 PHE A 975 −0.469 33.475 −23.348 1.00 51.62 C ATOM 7135 C PHE A 975 −3.436 35.223 −21.688 1.00 46.53 C ATOM 7136 O PHE A 975 −3.917 34.798 −22.752 1.00 47.55 O ATOM 7137 N VAL A 976 −3.644 36.452 −21.222 1.00 48.96 N ATOM 7138 CA VAL A 976 −4.474 37.411 −21.948 1.00 49.55 C ATOM 7139 CB VAL A 976 −5.817 37.636 −21.262 1.00 51.47 C ATOM 7140 CG1 VAL A 976 −6.628 38.625 −22.079 1.00 53.93 C ATOM 7141 CG2 VAL A 976 −6.580 36.330 −21.134 1.00 51.36 C ATOM 7142 C VAL A 976 −3.842 38.752 −22.078 1.00 46.77 C ATOM 7143 O VAL A 976 −3.628 39.380 −21.100 1.00 49.83 O ATOM 7144 N CYS A 977 −3.604 39.176 −23.301 1.00 50.68 N ATOM 7145 CA CYS A 977 −3.206 40.529 −23.666 1.00 54.98 C ATOM 7146 CB CYS A 977 −2.392 40.545 −24.946 1.00 59.61 C ATOM 7147 SG CYS A 977 −0.699 40.016 −24.649 1.00 86.62 S ATOM 7148 C CYS A 977 −4.427 41.334 −23.949 1.00 55.30 C ATOM 7149 O CYS A 977 −5.311 40.876 −24.667 1.00 47.62 O ATOM 7150 N GLN A 978 −4.453 42.554 −23.406 1.00 63.17 N ATOM 7151 CA GLN A 978 −5.487 43.560 −23.711 1.00 65.31 C ATOM 7152 CB GLN A 978 −6.066 44.077 −22.404 1.00 63.91 C ATOM 7153 CG GLN A 978 −7.260 44.976 −22.561 1.00 65.79 C ATOM 7154 CD GLN A 978 −7.736 45.491 −21.246 1.00 65.64 C ATOM 7155 OE1 GLN A 978 −7.438 46.627 −20.853 1.00 69.88 O ATOM 7156 NE2 GLN A 978 −8.470 44.667 −20.547 1.00 65.96 N ATOM 7157 C GLN A 978 −4.916 44.710 −24.574 1.00 66.95 C ATOM 7158 O GLN A 978 −3.704 44.970 −24.568 1.00 62.77 O ATOM 7159 N LYS A 979 −5.796 45.374 −25.325 1.00 73.27 N ATOM 7160 CA LYS A 979 −5.410 46.450 −26.243 1.00 76.39 C ATOM 7161 CB LYS A 979 −6.561 46.841 −27.193 1.00 75.17 C ATOM 7162 CG LYS A 979 −6.096 47.630 −28.411 1.00 73.67 C ATOM 7163 CD LYS A 979 −6.793 47.286 −29.728 1.00 76.23 C ATOM 7164 CE LYS A 979 −8.140 47.992 −29.956 1.00 79.69 C ATOM 7165 NZ LYS A 979 −8.701 47.816 −31.348 1.00 81.14 N ATOM 7166 C LYS A 979 −4.904 47.679 −25.536 1.00 82.02 C ATOM 7167 O LYS A 979 −3.778 48.112 −25.793 1.00 88.03 O ATOM 7168 N ASP A 980 −5.701 48.245 −24.643 1.00 86.88 N ATOM 7169 CA ASP A 980 −5.381 49.598 −24.184 1.00 100.91 C ATOM 7170 CB ASP A 980 −6.544 50.205 −23.388 1.00 108.29 C ATOM 7171 CG ASP A 980 −6.538 51.728 −23.414 1.00 107.18 C ATOM 7172 OD1 ASP A 980 −5.731 52.296 −24.189 1.00 106.93 O ATOM 7173 OD2 ASP A 980 −7.346 52.343 −22.670 1.00 99.48 O ATOM 7174 C ASP A 980 −4.083 49.686 −23.366 1.00 103.43 C ATOM 7175 O ASP A 980 −3.524 50.775 −23.195 1.00 103.93 O ATOM 7176 N GLU A 987 −0.390 57.816 −30.545 1.00 98.86 N ATOM 7177 CA GLU A 987 0.068 57.835 −29.153 1.00 108.31 C ATOM 7178 CB GLU A 987 −1.180 57.994 −28.206 1.00 105.31 C ATOM 7179 CG GLU A 987 −1.194 57.523 −26.723 1.00 103.73 C ATOM 7180 CD GLU A 987 −0.624 58.476 −25.643 1.00 93.34 C ATOM 7181 OE1 GLU A 987 −1.380 58.850 −24.689 1.00 78.76 O ATOM 7182 OE2 GLU A 987 0.588 58.785 −25.706 1.00 82.26 O ATOM 7183 C GLU A 987 0.983 56.590 −28.954 1.00 111.31 C ATOM 7184 O GLU A 987 1.225 55.828 −29.903 1.00 105.74 O ATOM 7185 N GLU A 988 1.543 56.427 −27.758 1.00 113.09 N ATOM 7186 CA GLU A 988 2.429 55.306 −27.455 1.00 114.52 C ATOM 7187 CB GLU A 988 3.588 55.849 −26.579 1.00 120.48 C ATOM 7188 CG GLU A 988 4.958 55.466 −27.080 1.00 118.12 C ATOM 7189 CD GLU A 988 5.017 53.982 −27.306 1.00 119.63 C ATOM 7190 OE1 GLU A 988 4.845 53.545 −28.463 1.00 127.22 O ATOM 7191 OE2 GLU A 988 5.134 53.257 −26.303 1.00 118.45 O ATOM 7192 C GLU A 988 1.685 54.060 −26.825 1.00 110.75 C ATOM 7193 O GLU A 988 2.261 53.245 −26.072 1.00 95.57 O ATOM 7194 N ARG A 989 0.405 53.909 −27.171 1.00 106.52 N ATOM 7195 CA ARG A 989 −0.402 52.772 −26.750 1.00 100.82 C ATOM 7196 CB ARG A 989 −1.625 53.279 −25.983 1.00 108.39 C ATOM 7197 CG ARG A 989 −1.241 54.049 −24.697 1.00 114.01 C ATOM 7198 CD ARG A 989 −2.422 54.643 −23.899 1.00 120.16 C ATOM 7199 NE ARG A 989 −3.120 55.743 −24.597 1.00 122.21 N ATOM 7200 CZ ARG A 989 −3.957 56.624 −24.040 1.00 119.07 C ATOM 7201 NH1 ARG A 989 −4.249 56.565 −22.741 1.00 122.71 N ATOM 7202 NH2 ARG A 989 −4.509 57.577 −24.795 1.00 113.39 N ATOM 7203 C ARG A 989 −0.689 51.885 −27.999 1.00 94.40 C ATOM 7204 O ARG A 989 −1.801 51.730 −28.510 1.00 78.14 O ATOM 7205 N GLN A 990 0.429 51.383 −28.506 1.00 91.30 N ATOM 7206 CA GLN A 990 0.521 50.275 −29.399 1.00 82.30 C ATOM 7207 CB GLN A 990 1.138 50.737 −30.738 1.00 82.57 C ATOM 7208 CG GLN A 990 2.594 51.225 −30.749 1.00 82.76 C ATOM 7209 CD GLN A 990 3.099 51.639 −32.155 1.00 88.52 C ATOM 7210 OE1 GLN A 990 4.186 52.190 −32.294 1.00 91.04 O ATOM 7211 NE2 GLN A 990 2.309 51.377 −33.192 1.00 88.90 N ATOM 7212 C GLN A 990 1.360 49.191 −28.690 1.00 80.55 C ATOM 7213 O GLN A 990 1.916 48.305 −29.309 1.00 77.62 O ATOM 7214 N HIS A 991 1.490 49.282 −27.378 1.00 82.07 N ATOM 7215 CA HIS A 991 1.878 48.126 −26.597 1.00 86.55 C ATOM 7216 CB HIS A 991 2.904 48.489 −25.479 1.00 92.72 C ATOM 7217 CG HIS A 991 2.469 48.119 −24.073 1.00 106.38 C ATOM 7218 ND1 HIS A 991 3.012 47.058 −23.370 1.00 112.16 N ATOM 7219 CE1 HIS A 991 2.453 46.987 −22.171 1.00 106.88 C ATOM 7220 NE2 HIS A 991 1.556 47.952 −22.070 1.00 101.78 N ATOM 7221 CD2 HIS A 991 1.548 48.677 −23.240 1.00 106.06 C ATOM 7222 C HIS A 991 0.536 47.517 −26.099 1.00 82.29 C ATOM 7223 O HIS A 991 −0.551 48.160 −26.150 1.00 72.97 O ATOM 7224 N LEU A 992 0.646 46.268 −25.644 1.00 74.63 N ATOM 7225 CA LEU A 992 −0.469 45.438 −25.253 1.00 66.18 C ATOM 7226 CB LEU A 992 −0.465 44.190 −26.113 1.00 61.01 C ATOM 7227 CG LEU A 992 −0.883 44.389 −27.559 1.00 58.69 C ATOM 7228 CD1 LEU A 992 −0.586 43.193 −28.422 1.00 59.54 C ATOM 7229 CD2 LEU A 992 −2.367 44.658 −27.623 1.00 59.53 C ATOM 7230 C LEU A 992 −0.224 45.059 −23.831 1.00 67.62 C ATOM 7231 O LEU A 992 0.830 44.503 −23.512 1.00 71.37 O ATOM 7232 N GLN A 993 −1.191 45.357 −22.976 1.00 71.58 N ATOM 7233 CA GLN A 993 −1.067 45.135 −21.520 1.00 75.64 C ATOM 7234 CB GLN A 993 −2.067 46.045 −20.720 1.00 86.63 C ATOM 7235 CG GLN A 993 −1.472 47.154 −19.846 1.00 90.67 C ATOM 7236 CD GLN A 993 −0.480 46.580 −18.859 1.00 95.83 C ATOM 7237 OE1 GLN A 993 −0.855 46.040 −17.812 1.00 99.60 O ATOM 7238 NE2 GLN A 993 0.797 46.639 −19.216 1.00 97.29 N ATOM 7239 C GLN A 993 −1.309 43.656 −21.207 1.00 65.97 C ATOM 7240 O GLN A 993 −2.217 43.076 −21.778 1.00 62.98 O ATOM 7241 N GLU A 994 −0.510 43.068 −20.320 1.00 58.75 N ATOM 7242 CA GLU A 994 −0.725 41.705 −19.898 1.00 60.59 C ATOM 7243 CB GLU A 994 0.622 41.128 −19.370 1.00 69.13 C ATOM 7244 CG GLU A 994 0.651 39.620 −19.003 1.00 80.18 C ATOM 7245 CD GLU A 994 2.072 39.000 −18.821 1.00 87.84 C ATOM 7246 OE1 GLU A 994 2.684 39.123 −17.722 1.00 91.40 O ATOM 7247 OE2 GLU A 994 2.567 38.332 −19.766 1.00 84.40 O ATOM 7248 C GLU A 994 −1.878 41.623 −18.846 1.00 56.24 C ATOM 7249 O GLU A 994 −1.600 41.526 −17.694 1.00 65.12 O ATOM 7250 N VAL A 995 −3.156 41.603 −19.206 1.00 51.00 N ATOM 7251 CA VAL A 995 −4.199 41.483 −18.185 1.00 51.00 C ATOM 7252 CB VAL A 995 −5.557 42.077 −18.593 1.00 54.56 C ATOM 7253 CG1 VAL A 995 −5.398 43.461 −19.181 1.00 56.13 C ATOM 7254 CG2 VAL A 995 −6.287 41.166 −19.551 1.00 59.73 C ATOM 7255 C VAL A 995 −4.534 40.103 −17.612 1.00 52.17 C ATOM 7256 O VAL A 995 −5.302 40.028 −16.626 1.00 53.25 O ATOM 7257 N GLY A 996 −4.039 39.017 −18.191 1.00 51.56 N ATOM 7258 CA GLY A 996 −4.476 37.685 −17.718 1.00 52.92 C ATOM 7259 C GLY A 996 −3.380 36.641 −17.578 1.00 51.95 C ATOM 7260 O GLY A 996 −2.546 36.508 −18.474 1.00 50.70 O ATOM 7261 N LEU A 997 −3.384 35.894 −16.474 1.00 49.49 N ATOM 7262 CA LEU A 997 −2.482 34.766 −16.317 1.00 52.22 C ATOM 7263 CB LEU A 997 −1.225 35.207 −15.602 1.00 55.28 C ATOM 7264 CG LEU A 997 −0.390 36.327 −16.202 1.00 58.91 C ATOM 7265 CD1 LEU A 997 0.764 36.654 −15.270 1.00 60.90 C ATOM 7266 CD2 LEU A 997 0.153 35.986 −17.576 1.00 60.13 C ATOM 7267 C LEU A 997 −3.065 33.642 −15.495 1.00 51.77 C ATOM 7268 O LEU A 997 −3.658 33.900 −14.463 1.00 54.23 O ATOM 7269 N PHE A 998 −2.813 32.396 −15.897 1.00 48.48 N ATOM 7270 CA PHE A 998 −3.459 31.247 −15.289 1.00 44.78 C ATOM 7271 CB PHE A 998 −4.883 31.212 −15.793 1.00 44.74 C ATOM 7272 CG PHE A 998 −5.744 30.255 −15.081 1.00 49.19 C ATOM 7273 CD1 PHE A 998 −6.311 30.595 −13.855 1.00 52.21 C ATOM 7274 CE1 PHE A 998 −7.141 29.702 −13.160 1.00 50.23 C ATOM 7275 CZ PHE A 998 −7.395 28.464 −13.688 1.00 51.06 C ATOM 7276 CE2 PHE A 998 −6.839 28.111 −14.922 1.00 51.43 C ATOM 7277 CD2 PHE A 998 −6.021 29.008 −15.612 1.00 51.59 C ATOM 7278 C PHE A 998 −2.736 29.983 −15.685 1.00 43.79 C ATOM 7279 O PHE A 998 −2.464 29.775 −16.859 1.00 44.52 O ATOM 7280 N HIS A 999 −2.397 29.133 −14.727 1.00 44.60 N ATOM 7281 CA HIS A 999 −1.932 27.773 −15.066 1.00 44.12 C ATOM 7282 CB HIS A 999 −1.040 27.219 −14.006 1.00 41.81 C ATOM 7283 CG HIS A 999 −0.269 26.009 −14.427 1.00 43.29 C ATOM 7284 ND1 HIS A 999 −0.430 24.781 −13.823 1.00 44.49 N ATOM 7285 CE1 HIS A 999 0.443 23.920 −14.322 1.00 43.78 C ATOM 7286 NE2 HIS A 999 1.177 24.553 −15.217 1.00 44.01 N ATOM 7287 CD2 HIS A 999 0.755 25.857 −15.302 1.00 43.81 C ATOM 7288 C HIS A 999 −3.138 26.840 −15.248 1.00 45.96 C ATOM 7289 O HIS A 999 −3.880 26.582 −14.290 1.00 46.12 O ATOM 7290 N LEU A 1000 −3.342 26.379 −16.487 1.00 44.89 N ATOM 7291 CA LEU A 1000 −4.443 25.496 −16.830 1.00 43.56 C ATOM 7292 CB LEU A 1000 −4.613 25.507 −18.311 1.00 42.72 C ATOM 7293 CG LEU A 1000 −5.782 24.809 −18.957 1.00 42.86 C ATOM 7294 CD1 LEU A 1000 −7.080 25.324 −18.374 1.00 41.73 C ATOM 7295 CD2 LEU A 1000 −5.743 25.076 −20.466 1.00 43.05 C ATOM 7296 C LEU A 1000 −4.151 24.085 −16.422 1.00 43.72 C ATOM 7297 O LEU A 1000 −5.031 23.386 −15.956 1.00 45.46 O ATOM 7298 N GLY A 1001 −2.905 23.684 −16.599 1.00 43.69 N ATOM 7299 CA GLY A 1001 −2.502 22.304 −16.439 1.00 45.32 C ATOM 7300 C GLY A 1001 −2.738 21.421 −17.672 1.00 46.19 C ATOM 7301 O GLY A 1001 −2.531 20.206 −17.582 1.00 41.98 O ATOM 7302 N GLU A 1002 −3.189 22.028 −18.786 1.00 46.89 N ATOM 7303 CA GLU A 1002 −3.293 21.373 −20.092 1.00 47.52 C ATOM 7304 CB GLU A 1002 −4.758 21.263 −20.505 1.00 47.12 C ATOM 7305 CG GLU A 1002 −5.606 20.397 −19.593 1.00 47.47 C ATOM 7306 CD GLU A 1002 −5.145 18.952 −19.512 1.00 49.79 C ATOM 7307 OE1 GLU A 1002 −4.331 18.432 −20.349 1.00 52.28 O ATOM 7308 OE2 GLU A 1002 −5.611 18.314 −18.572 1.00 49.64 O ATOM 7309 C GLU A 1002 −2.594 22.139 −21.191 1.00 45.93 C ATOM 7310 O GLU A 1002 −2.403 23.322 −21.088 1.00 50.33 O ATOM 7311 N PHE A 1003 −2.294 21.451 −22.285 1.00 44.36 N ATOM 7312 CA PHE A 1003 −1.674 22.038 −23.492 1.00 39.17 C ATOM 7313 CB PHE A 1003 −0.625 21.079 −24.027 1.00 40.24 C ATOM 7314 CG PHE A 1003 0.277 21.642 −25.061 1.00 40.13 C ATOM 7315 CD1 PHE A 1003 −0.176 21.924 −26.329 1.00 42.98 C ATOM 7316 CE1 PHE A 1003 0.705 22.414 −27.287 1.00 43.30 C ATOM 7317 CZ PHE A 1003 2.037 22.602 −26.983 1.00 39.67 C ATOM 7318 CE2 PHE A 1003 2.491 22.282 −25.743 1.00 37.67 C ATOM 7319 CD2 PHE A 1003 1.623 21.793 −24.799 1.00 39.24 C ATOM 7320 C PHE A 1003 −2.745 22.222 −24.534 1.00 37.69 C ATOM 7321 O PHE A 1003 −3.375 21.281 −24.993 1.00 38.92 O ATOM 7322 N VAL A 1004 −2.950 23.457 −24.930 1.00 38.24 N ATOM 7323 CA VAL A 1004 −4.039 23.804 −25.829 1.00 36.67 C ATOM 7324 CB VAL A 1004 −4.546 25.183 −25.502 1.00 34.37 C ATOM 7325 CG1 VAL A 1004 −5.690 25.541 −26.424 1.00 34.56 C ATOM 7326 CG2 VAL A 1004 −4.973 25.151 −24.059 1.00 35.40 C ATOM 7327 C VAL A 1004 −3.574 23.805 −27.255 1.00 35.51 C ATOM 7328 O VAL A 1004 −2.604 24.439 −27.566 1.00 34.42 O ATOM 7329 N ASN A 1005 −4.272 23.082 −28.109 1.00 36.66 N ATOM 7330 CA ASN A 1005 −3.964 23.094 −29.527 1.00 37.57 C ATOM 7331 CB ASN A 1005 −4.112 21.716 −30.138 1.00 37.70 C ATOM 7332 CG ASN A 1005 −2.947 20.831 −29.842 1.00 37.63 C ATOM 7333 OD1 ASN A 1005 −1.794 21.243 −29.817 1.00 40.58 O ATOM 7334 ND2 ASN A 1005 −3.239 19.604 −29.625 1.00 38.98 N ATOM 7335 C ASN A 1005 −4.838 24.043 −30.285 1.00 37.10 C ATOM 7336 O ASN A 1005 −4.350 24.724 −31.180 1.00 39.51 O ATOM 7337 N VAL A 1006 −6.098 24.106 −29.924 1.00 34.97 N ATOM 7338 CA VAL A 1006 −7.027 24.819 −30.702 1.00 37.16 C ATOM 7339 CB VAL A 1006 −7.849 23.858 −31.554 1.00 41.02 C ATOM 7340 CG1 VAL A 1006 −8.489 22.685 −30.756 1.00 44.02 C ATOM 7341 CG2 VAL A 1006 −8.958 24.618 −32.228 1.00 41.86 C ATOM 7342 C VAL A 1006 −7.948 25.548 −29.777 1.00 39.51 C ATOM 7343 O VAL A 1006 −8.330 25.023 −28.744 1.00 42.91 O ATOM 7344 N PHE A 1007 −8.292 26.770 −30.145 1.00 42.10 N ATOM 7345 CA PHE A 1007 −9.394 27.494 −29.526 1.00 41.88 C ATOM 7346 CB PHE A 1007 −9.051 28.929 −29.121 1.00 41.03 C ATOM 7347 CG PHE A 1007 −8.105 29.054 −27.959 1.00 39.08 C ATOM 7348 CD1 PHE A 1007 −8.580 28.954 −26.674 1.00 37.79 C ATOM 7349 CE1 PHE A 1007 −7.756 29.115 −25.609 1.00 38.32 C ATOM 7350 CZ PHE A 1007 −6.404 29.398 −25.823 1.00 40.79 C ATOM 7351 CE2 PHE A 1007 −5.906 29.532 −27.125 1.00 38.93 C ATOM 7352 CD2 PHE A 1007 −6.758 29.348 −28.174 1.00 37.86 C ATOM 7353 C PHE A 1007 −10.357 27.627 −30.635 1.00 43.34 C ATOM 7354 O PHE A 1007 −9.946 27.751 −31.800 1.00 42.02 O ATOM 7355 N CYS A 1008 −11.631 27.660 −30.265 1.00 48.10 N ATOM 7356 CA CYS A 1008 −12.686 27.973 −31.211 1.00 52.33 C ATOM 7357 CB CYS A 1008 −12.862 26.786 −32.153 1.00 56.36 C ATOM 7358 SG CYS A 1008 −14.340 25.896 −31.875 1.00 65.02 S ATOM 7359 C CYS A 1008 −14.007 28.452 −30.569 1.00 48.86 C ATOM 7360 O CYS A 1008 −14.471 27.929 −29.580 1.00 47.72 O ATOM 7361 N HIS A 1009 −14.567 29.499 −31.133 1.00 49.60 N ATOM 7362 CA HIS A 1009 −15.731 30.163 −30.558 1.00 49.55 C ATOM 7363 CB HIS A 1009 −16.059 31.505 −31.260 1.00 47.71 C ATOM 7364 CG HIS A 1009 −15.060 32.582 −31.015 1.00 48.72 C ATOM 7365 ND1 HIS A 1009 −15.292 33.622 −30.141 1.00 52.52 N ATOM 7366 CE1 HIS A 1009 −14.231 34.410 −30.105 1.00 53.27 C ATOM 7367 NE2 HIS A 1009 −13.309 33.906 −30.908 1.00 51.98 N ATOM 7368 CD2 HIS A 1009 −13.810 32.769 −31.500 1.00 50.64 C ATOM 7369 C HIS A 1009 −16.861 29.226 −30.837 1.00 47.82 C ATOM 7370 O HIS A 1009 −16.987 28.735 −31.926 1.00 52.26 O ATOM 7371 N GLY A 1010 −17.674 28.988 −29.850 1.00 45.57 N ATOM 7372 CA GLY A 1010 −18.898 28.274 −30.047 1.00 46.62 C ATOM 7373 C GLY A 1010 −19.327 27.839 −28.662 1.00 46.22 C ATOM 7374 O GLY A 1010 −18.611 28.083 −27.692 1.00 43.44 O ATOM 7375 N SER A 1011 −20.494 27.213 −28.580 1.00 44.17 N ATOM 7376 CA SER A 1011 −20.949 26.666 −27.348 1.00 44.22 C ATOM 7377 CB SER A 1011 −21.650 27.770 −26.593 1.00 45.19 C ATOM 7378 OG SER A 1011 −22.792 27.383 −25.871 1.00 48.14 O ATOM 7379 C SER A 1011 −21.824 25.459 −27.614 1.00 46.61 C ATOM 7380 O SER A 1011 −22.501 25.381 −28.665 1.00 44.23 O ATOM 7381 N LEU A 1012 −21.807 24.525 −26.649 1.00 49.13 N ATOM 7382 CA LEU A 1012 −22.606 23.295 −26.716 1.00 50.67 C ATOM 7383 CB LEU A 1012 −21.789 22.061 −26.356 1.00 51.41 C ATOM 7384 CG LEU A 1012 −20.296 22.060 −26.637 1.00 55.02 C ATOM 7385 CD1 LEU A 1012 −19.593 21.110 −25.681 1.00 59.04 C ATOM 7386 CD2 LEU A 1012 −20.023 21.695 −28.067 1.00 58.13 C ATOM 7387 C LEU A 1012 −23.872 23.348 −25.850 1.00 52.62 C ATOM 7388 O LEU A 1012 −24.378 22.293 −25.495 1.00 57.41 O ATOM 7389 N VAL A 1013 −24.409 24.535 −25.540 1.00 54.08 N ATOM 7390 CA VAL A 1013 −25.751 24.631 −24.931 1.00 58.27 C ATOM 7391 CB VAL A 1013 −25.725 25.185 −23.512 1.00 54.60 C ATOM 7392 CG1 VAL A 1013 −24.982 24.246 −22.617 1.00 56.58 C ATOM 7393 CG2 VAL A 1013 −25.076 26.524 −23.470 1.00 56.15 C ATOM 7394 C VAL A 1013 −26.705 25.441 −25.800 1.00 65.09 C ATOM 7395 O VAL A 1013 −26.261 26.076 −26.751 1.00 67.17 O ATOM 7396 N MET A 1014 −28.000 25.379 −25.478 1.00 70.99 N ATOM 7397 CA MET A 1014 −29.029 25.993 −26.276 1.00 75.07 C ATOM 7398 CB MET A 1014 −30.277 25.098 −26.367 1.00 84.03 C ATOM 7399 CG MET A 1014 −29.990 23.676 −26.876 1.00 90.96 C ATOM 7400 SD MET A 1014 −31.317 22.630 −27.616 1.00 109.59 S ATOM 7401 CE MET A 1014 −32.615 22.593 −26.358 1.00 100.77 C ATOM 7402 C MET A 1014 −29.327 27.325 −25.659 1.00 70.94 C ATOM 7403 O MET A 1014 −29.336 28.311 −26.386 1.00 73.82 O ATOM 7404 N THR A 1024 −21.952 36.019 −17.479 1.00 59.52 N ATOM 7405 CA THR A 1024 −21.084 35.540 −18.622 1.00 61.75 C ATOM 7406 CB THR A 1024 −21.136 34.016 −18.815 1.00 66.10 C ATOM 7407 OG1 THR A 1024 −22.455 33.603 −19.267 1.00 64.43 O ATOM 7408 CG2 THR A 1024 −20.711 33.314 −17.494 1.00 67.78 C ATOM 7409 C THR A 1024 −21.366 36.067 −20.029 1.00 58.82 C ATOM 7410 O THR A 1024 −22.490 36.039 −20.490 1.00 58.68 O ATOM 7411 N GLN A 1025 −20.307 36.493 −20.708 1.00 65.07 N ATOM 7412 CA GLN A 1025 −20.349 37.049 −22.076 1.00 71.43 C ATOM 7413 CB GLN A 1025 −20.179 38.594 −22.063 1.00 83.00 C ATOM 7414 CG GLN A 1025 −21.095 39.415 −21.096 1.00 91.73 C ATOM 7415 CD GLN A 1025 −20.421 40.087 −19.837 1.00 93.79 C ATOM 7416 OE1 GLN A 1025 −19.265 40.618 −19.845 1.00 87.63 O ATOM 7417 NE2 GLN A 1025 −21.197 40.109 −18.753 1.00 92.61 N ATOM 7418 C GLN A 1025 −19.222 36.383 −22.929 1.00 68.26 C ATOM 7419 O GLN A 1025 −18.021 36.346 −22.523 1.00 62.24 O ATOM 7420 N GLY A 1026 −19.622 35.834 −24.087 1.00 61.12 N ATOM 7421 CA GLY A 1026 −18.732 35.082 −24.947 1.00 56.20 C ATOM 7422 C GLY A 1026 −18.714 33.612 −24.562 1.00 57.05 C ATOM 7423 O GLY A 1026 −19.130 33.230 −23.483 1.00 55.87 O ATOM 7424 N SER A 1027 −18.268 32.780 −25.496 1.00 56.89 N ATOM 7425 CA SER A 1027 −17.950 31.380 −25.263 1.00 50.84 C ATOM 7426 CB SER A 1027 −19.171 30.501 −25.544 1.00 49.63 C ATOM 7427 OG SER A 1027 −19.184 29.260 −24.793 1.00 49.52 O ATOM 7428 C SER A 1027 −16.798 31.046 −26.208 1.00 49.11 C ATOM 7429 O SER A 1027 −16.923 31.183 −27.408 1.00 50.75 O ATOM 7430 N VAL A 1028 −15.660 30.642 −25.662 1.00 48.63 N ATOM 7431 CA VAL A 1028 −14.569 30.066 −26.461 1.00 44.94 C ATOM 7432 CB VAL A 1028 −13.395 30.984 −26.442 1.00 41.96 C ATOM 7433 CG1 VAL A 1028 −12.138 30.240 −26.800 1.00 41.75 C ATOM 7434 CG2 VAL A 1028 −13.712 32.058 −27.433 1.00 42.57 C ATOM 7435 C VAL A 1028 −14.173 28.711 −25.936 1.00 41.85 C ATOM 7436 O VAL A 1028 −13.858 28.583 −24.796 1.00 41.88 O ATOM 7437 N LEU A 1029 −14.224 27.714 −26.799 1.00 41.31 N ATOM 7438 CA LEU A 1029 −13.955 26.337 −26.430 1.00 42.43 C ATOM 7439 CB LEU A 1029 −14.841 25.346 −27.209 1.00 43.17 C ATOM 7440 CG LEU A 1029 −16.297 25.397 −26.701 1.00 44.23 C ATOM 7441 CD1 LEU A 1029 −17.366 24.881 −27.677 1.00 42.25 C ATOM 7442 CD2 LEU A 1029 −16.356 24.685 −25.345 1.00 46.45 C ATOM 7443 C LEU A 1029 −12.541 26.110 −26.787 1.00 41.69 C ATOM 7444 O LEU A 1029 −12.040 26.693 −27.712 1.00 45.25 O ATOM 7445 N PHE A 1030 −11.884 25.245 −26.063 1.00 40.29 N ATOM 7446 CA PHE A 1030 −10.583 24.828 −26.483 1.00 39.72 C ATOM 7447 CB PHE A 1030 −9.491 25.626 −25.776 1.00 39.45 C ATOM 7448 CG PHE A 1030 −9.541 25.535 −24.290 1.00 38.57 C ATOM 7449 CD1 PHE A 1030 −8.886 24.538 −23.630 1.00 39.49 C ATOM 7450 CE1 PHE A 1030 −8.913 24.470 −22.244 1.00 38.97 C ATOM 7451 CZ PHE A 1030 −9.584 25.394 −21.530 1.00 36.69 C ATOM 7452 CE2 PHE A 1030 −10.269 26.372 −22.188 1.00 37.51 C ATOM 7453 CD2 PHE A 1030 −10.242 26.447 −23.554 1.00 38.03 C ATOM 7454 C PHE A 1030 −10.443 23.364 −26.201 1.00 39.24 C ATOM 7455 O PHE A 1030 −11.147 22.800 −25.342 1.00 38.02 O ATOM 7456 N GLY A 1031 −9.532 22.777 −26.961 1.00 37.68 N ATOM 7457 CA GLY A 1031 −9.280 21.375 −26.918 1.00 36.44 C ATOM 7458 C GLY A 1031 −7.815 21.239 −26.737 1.00 35.68 C ATOM 7459 O GLY A 1031 −7.049 22.127 −27.055 1.00 36.80 O ATOM 7460 N THR A 1032 −7.434 20.064 −26.308 1.00 35.56 N ATOM 7461 CA THR A 1032 −6.243 19.908 −25.608 1.00 36.11 C ATOM 7462 CB THR A 1032 −6.714 19.972 −24.153 1.00 36.91 C ATOM 7463 OG1 THR A 1032 −6.093 21.078 −23.511 1.00 44.15 O ATOM 7464 CG2 THR A 1032 −6.552 18.705 −23.402 1.00 34.16 C ATOM 7465 C THR A 1032 −5.627 18.578 −25.987 1.00 36.48 C ATOM 7466 O THR A 1032 −6.324 17.691 −26.437 1.00 39.40 O ATOM 7467 N VAL A 1033 −4.339 18.428 −25.726 1.00 34.84 N ATOM 7468 CA VAL A 1033 −3.580 17.187 −25.909 1.00 33.06 C ATOM 7469 CB VAL A 1033 −2.117 17.493 −25.578 1.00 33.29 C ATOM 7470 CG1 VAL A 1033 −1.230 16.266 −25.527 1.00 33.27 C ATOM 7471 CG2 VAL A 1033 −1.550 18.481 −26.607 1.00 33.71 C ATOM 7472 C VAL A 1033 −4.034 15.946 −25.102 1.00 35.01 C ATOM 7473 O VAL A 1033 −3.920 14.804 −25.553 1.00 39.90 O ATOM 7474 N ASN A 1034 −4.472 16.126 −23.872 1.00 37.09 N ATOM 7475 CA ASN A 1034 −4.984 15.024 −23.077 1.00 35.32 C ATOM 7476 CB ASN A 1034 −4.703 15.270 −21.609 1.00 37.64 C ATOM 7477 CG ASN A 1034 −3.226 15.249 −21.302 1.00 40.92 C ATOM 7478 OD1 ASN A 1034 −2.755 15.738 −20.263 1.00 45.55 O ATOM 7479 ND2 ASN A 1034 −2.468 14.714 −22.237 1.00 41.59 N ATOM 7480 C ASN A 1034 −6.406 14.824 −23.296 1.00 35.09 C ATOM 7481 O ASN A 1034 −7.022 14.104 −22.578 1.00 35.36 O ATOM 7482 N GLY A 1035 −6.966 15.434 −24.315 1.00 37.74 N ATOM 7483 CA GLY A 1035 −8.377 15.256 −24.572 1.00 39.04 C ATOM 7484 C GLY A 1035 −9.312 15.965 −23.633 1.00 38.69 C ATOM 7485 O GLY A 1035 −10.496 15.786 −23.721 1.00 37.94 O ATOM 7486 N MET A 1036 −8.799 16.752 −22.709 1.00 42.94 N ATOM 7487 CA MET A 1036 −9.644 17.699 −21.971 1.00 43.94 C ATOM 7488 CB MET A 1036 −8.910 18.275 −20.741 1.00 45.17 C ATOM 7489 CG MET A 1036 −9.588 19.436 −20.048 1.00 49.35 C ATOM 7490 SD MET A 1036 −9.137 21.149 −20.455 1.00 49.86 S ATOM 7491 CE MET A 1036 −10.280 21.875 −19.332 1.00 48.33 C ATOM 7492 C MET A 1036 −10.115 18.770 −22.946 1.00 41.84 C ATOM 7493 O MET A 1036 −9.478 19.034 −23.941 1.00 42.75 O ATOM 7494 N ILE A 1037 −11.304 19.267 −22.675 1.00 41.82 N ATOM 7495 CA ILE A 1037 −11.989 20.321 −23.396 1.00 40.94 C ATOM 7496 CB ILE A 1037 −13.262 19.816 −24.074 1.00 36.88 C ATOM 7497 CG1 ILE A 1037 −12.948 18.734 −25.088 1.00 35.90 C ATOM 7498 CD1 ILE A 1037 −14.165 18.095 −25.751 1.00 34.79 C ATOM 7499 CG2 ILE A 1037 −13.967 20.952 −24.761 1.00 38.65 C ATOM 7500 C ILE A 1037 −12.412 21.353 −22.324 1.00 45.81 C ATOM 7501 O ILE A 1037 −12.953 20.993 −21.242 1.00 42.24 O ATOM 7502 N GLY A 1038 −12.159 22.626 −22.626 1.00 49.31 N ATOM 7503 CA GLY A 1038 −12.446 23.707 −21.697 1.00 49.82 C ATOM 7504 C GLY A 1038 −13.183 24.795 −22.409 1.00 50.61 C ATOM 7505 O GLY A 1038 −13.190 24.873 −23.624 1.00 53.74 O ATOM 7506 N LEU A 1039 −13.834 25.615 −21.625 1.00 50.99 N ATOM 7507 CA LEU A 1039 −14.609 26.699 −22.114 1.00 49.89 C ATOM 7508 CB LEU A 1039 −16.044 26.412 −21.728 1.00 50.42 C ATOM 7509 CG LEU A 1039 −16.920 27.623 −21.944 1.00 55.77 C ATOM 7510 CD1 LEU A 1039 −18.265 27.265 −22.532 1.00 60.64 C ATOM 7511 CD2 LEU A 1039 −17.147 28.300 −20.611 1.00 60.54 C ATOM 7512 C LEU A 1039 −14.055 27.967 −21.458 1.00 48.92 C ATOM 7513 O LEU A 1039 −13.716 27.995 −20.277 1.00 50.79 O ATOM 7514 N VAL A 1040 −13.964 29.046 −22.201 1.00 49.48 N ATOM 7515 CA VAL A 1040 −13.620 30.334 −21.586 1.00 46.33 C ATOM 7516 CB VAL A 1040 −12.318 30.885 −22.113 1.00 42.74 C ATOM 7517 CG1 VAL A 1040 −12.104 32.274 −21.587 1.00 43.78 C ATOM 7518 CG2 VAL A 1040 −11.185 30.033 −21.613 1.00 43.78 C ATOM 7519 C VAL A 1040 −14.721 31.325 −21.845 1.00 48.14 C ATOM 7520 O VAL A 1040 −15.203 31.441 −22.965 1.00 54.01 O ATOM 7521 N THR A 1041 −15.133 32.040 −20.814 1.00 49.61 N ATOM 7522 CA THR A 1041 −16.107 33.089 −20.987 1.00 51.39 C ATOM 7523 CB THR A 1041 −17.458 32.637 −20.490 1.00 52.65 C ATOM 7524 OG1 THR A 1041 −18.422 33.491 −21.057 1.00 58.22 O ATOM 7525 CG2 THR A 1041 −17.567 32.704 −18.999 1.00 54.27 C ATOM 7526 C THR A 1041 −15.631 34.311 −20.272 1.00 52.38 C ATOM 7527 O THR A 1041 −14.598 34.266 −19.642 1.00 53.56 O ATOM 7528 N SER A 1042 −16.370 35.405 −20.386 1.00 57.34 N ATOM 7529 CA SER A 1042 −15.934 36.714 −19.848 1.00 58.09 C ATOM 7530 CB SER A 1042 −15.638 37.680 −20.995 1.00 60.08 C ATOM 7531 OG SER A 1042 −14.627 37.105 −21.821 1.00 66.91 O ATOM 7532 C SER A 1042 −16.977 37.260 −18.899 1.00 53.93 C ATOM 7533 O SER A 1042 −18.128 36.964 −19.054 1.00 52.87 O ATOM 7534 N LEU A 1043 −16.555 38.033 −17.904 1.00 54.58 N ATOM 7535 CA LEU A 1043 −17.401 38.426 −16.778 1.00 54.73 C ATOM 7536 CB LEU A 1043 −16.823 37.826 −15.507 1.00 55.25 C ATOM 7537 CG LEU A 1043 −16.824 36.319 −15.310 1.00 55.96 C ATOM 7538 CD1 LEU A 1043 −16.299 35.941 −13.925 1.00 55.37 C ATOM 7539 CD2 LEU A 1043 −18.225 35.771 −15.543 1.00 58.16 C ATOM 7540 C LEU A 1043 −17.415 39.911 −16.539 1.00 56.39 C ATOM 7541 O LEU A 1043 −16.418 40.582 −16.778 1.00 57.04 O ATOM 7542 N SER A 1044 −18.513 40.408 −15.974 1.00 57.59 N ATOM 7543 CA SER A 1044 −18.525 41.781 −15.448 1.00 58.17 C ATOM 7544 CB SER A 1044 −19.957 42.332 −15.167 1.00 61.70 C ATOM 7545 OG SER A 1044 −20.589 41.822 −13.991 1.00 62.51 O ATOM 7546 C SER A 1044 −17.673 41.842 −14.203 1.00 57.72 C ATOM 7547 O SER A 1044 −17.726 40.939 −13.340 1.00 53.14 O ATOM 7548 N GLU A 1045 −16.899 42.922 −14.123 1.00 60.20 N ATOM 7549 CA GLU A 1045 −16.081 43.224 −12.940 1.00 62.00 C ATOM 7550 CB GLU A 1045 −15.651 44.691 −12.943 1.00 64.15 C ATOM 7551 CG GLU A 1045 −14.409 44.897 −12.106 1.00 67.58 C ATOM 7552 CD GLU A 1045 −14.101 46.330 −11.732 1.00 71.08 C ATOM 7553 OE1 GLU A 1045 −14.963 47.230 −11.941 1.00 68.89 O ATOM 7554 OE2 GLU A 1045 −12.987 46.501 −11.160 1.00 71.84 O ATOM 7555 C GLU A 1045 −16.754 42.906 −11.591 1.00 59.68 C ATOM 7556 O GLU A 1045 −16.132 42.302 −10.718 1.00 54.67 O ATOM 7557 N SER A 1046 −18.003 43.330 −11.415 1.00 60.36 N ATOM 7558 CA SER A 1046 −18.736 42.979 −10.200 1.00 65.65 C ATOM 7559 CB SER A 1046 −20.235 43.394 −10.304 1.00 69.51 C ATOM 7560 OG SER A 1046 −21.126 42.589 −9.492 1.00 73.62 O ATOM 7561 C SER A 1046 −18.553 41.464 −9.894 1.00 65.72 C ATOM 7562 O SER A 1046 −18.059 41.098 −8.808 1.00 65.05 O ATOM 7563 N TRP A 1047 −18.903 40.623 −10.884 1.00 64.65 N ATOM 7564 CA TRP A 1047 −18.928 39.151 −10.742 1.00 62.81 C ATOM 7565 CB TRP A 1047 −19.624 38.452 −11.935 1.00 66.63 C ATOM 7566 CG TRP A 1047 −21.144 38.317 −11.809 1.00 69.96 C ATOM 7567 CD1 TRP A 1047 −22.083 39.091 −12.404 1.00 67.97 C ATOM 7568 NE1 TRP A 1047 −23.335 38.669 −12.064 1.00 67.73 N ATOM 7569 CE2 TRP A 1047 −23.232 37.595 −11.236 1.00 73.62 C ATOM 7570 CD2 TRP A 1047 −21.862 37.342 −11.055 1.00 76.16 C ATOM 7571 CE3 TRP A 1047 −21.476 36.291 −10.220 1.00 88.56 C ATOM 7572 CZ3 TRP A 1047 −22.473 35.527 −9.586 1.00 89.66 C ATOM 7573 CH2 TRP A 1047 −23.832 35.806 −9.794 1.00 86.74 C ATOM 7574 CZ2 TRP A 1047 −24.228 36.836 −10.616 1.00 81.04 C ATOM 7575 C TRP A 1047 −17.520 38.611 −10.599 1.00 56.09 C ATOM 7576 O TRP A 1047 −17.246 37.727 −9.787 1.00 51.59 O ATOM 7577 N TYR A 1048 −16.612 39.149 −11.379 1.00 49.72 N ATOM 7578 CA TYR A 1048 −15.266 38.770 −11.165 1.00 50.25 C ATOM 7579 CB TYR A 1048 −14.313 39.545 −12.055 1.00 52.38 C ATOM 7580 CG TYR A 1048 −12.878 39.156 −11.835 1.00 52.06 C ATOM 7581 CD1 TYR A 1048 −12.275 38.133 −12.553 1.00 50.52 C ATOM 7582 CE1 TYR A 1048 −10.961 37.768 −12.304 1.00 51.48 C ATOM 7583 CZ TYR A 1048 −10.247 38.438 −11.329 1.00 54.64 C ATOM 7584 OH TYR A 1048 −8.921 38.200 −11.008 1.00 55.15 O ATOM 7585 CE2 TYR A 1048 −10.849 39.440 −10.614 1.00 56.97 C ATOM 7586 CD2 TYR A 1048 −12.152 39.781 −10.860 1.00 54.33 C ATOM 7587 C TYR A 1048 −14.908 38.960 −9.708 1.00 51.25 C ATOM 7588 O TYR A 1048 −14.355 38.057 −9.098 1.00 52.40 O ATOM 7589 N ASN A 1049 −15.223 40.120 −9.134 1.00 54.11 N ATOM 7590 CA ASN A 1049 −14.808 40.379 −7.743 1.00 52.68 C ATOM 7591 CB ASN A 1049 −15.020 41.821 −7.385 1.00 52.68 C ATOM 7592 CG ASN A 1049 −14.035 42.706 −8.078 1.00 53.71 C ATOM 7593 OD1 ASN A 1049 −12.839 42.426 −8.113 1.00 52.42 O ATOM 7594 ND2 ASN A 1049 −14.531 43.774 −8.659 1.00 58.26 N ATOM 7595 C ASN A 1049 −15.443 39.468 −6.721 1.00 49.46 C ATOM 7596 O ASN A 1049 −14.757 38.913 −5.864 1.00 44.45 O ATOM 7597 N LEU A 1050 −16.742 39.293 −6.858 1.00 48.92 N ATOM 7598 CA LEU A 1050 −17.464 38.349 −6.053 1.00 51.63 C ATOM 7599 CB LEU A 1050 −18.873 38.250 −6.565 1.00 51.31 C ATOM 7600 CG LEU A 1050 −19.711 37.148 −5.959 1.00 54.05 C ATOM 7601 CD1 LEU A 1050 −19.619 37.080 −4.451 1.00 56.95 C ATOM 7602 CD2 LEU A 1050 −21.137 37.428 −6.346 1.00 58.09 C ATOM 7603 C LEU A 1050 −16.852 36.963 −6.081 1.00 56.96 C ATOM 7604 O LEU A 1050 −16.511 36.379 −5.015 1.00 65.50 O ATOM 7605 N LEU A 1051 −16.732 36.422 −7.297 1.00 55.43 N ATOM 7606 CA LEU A 1051 −16.262 35.044 −7.471 1.00 49.96 C ATOM 7607 CB LEU A 1051 −16.380 34.580 −8.923 1.00 48.32 C ATOM 7608 CG LEU A 1051 −17.779 34.495 −9.527 1.00 46.10 C ATOM 7609 CD1 LEU A 1051 −17.616 34.302 −11.029 1.00 46.82 C ATOM 7610 CD2 LEU A 1051 −18.630 33.399 −8.924 1.00 44.19 C ATOM 7611 C LEU A 1051 −14.845 34.864 −6.994 1.00 46.84 C ATOM 7612 O LEU A 1051 −14.516 33.765 −6.560 1.00 47.42 O ATOM 7613 N LEU A 1052 −14.029 35.925 −7.052 1.00 44.50 N ATOM 7614 CA LEU A 1052 −12.649 35.866 −6.527 1.00 46.59 C ATOM 7615 CB LEU A 1052 −11.855 37.132 −6.836 1.00 45.91 C ATOM 7616 CG LEU A 1052 −10.381 36.841 −7.096 1.00 47.36 C ATOM 7617 CD1 LEU A 1052 −9.641 38.126 −7.440 1.00 47.80 C ATOM 7618 CD2 LEU A 1052 −9.680 36.106 −5.962 1.00 49.67 C ATOM 7619 C LEU A 1052 −12.633 35.676 −5.028 1.00 48.30 C ATOM 7620 O LEU A 1052 −11.866 34.872 4.494 1.00 45.08 O ATOM 7621 N ASP A 1053 −13.475 36.455 −4.350 1.00 55.11 N ATOM 7622 CA ASP A 1053 −13.581 36.375 −2.916 1.00 60.36 C ATOM 7623 CB ASP A 1053 −14.637 37.365 −2.342 1.00 65.76 C ATOM 7624 CG ASP A 1053 −14.592 37.478 −0.769 1.00 70.90 C ATOM 7625 OD1 ASP A 1053 −13.540 37.214 −0.121 1.00 68.20 O ATOM 7626 OD2 ASP A 1053 −15.641 37.825 −0.179 1.00 76.05 O ATOM 7627 C ASP A 1053 −13.946 34.920 −2.692 1.00 58.30 C ATOM 7628 O ASP A 1053 −13.261 34.178 −1.956 1.00 57.98 O ATOM 7629 N MET A 1054 −14.969 34.490 −3.410 1.00 55.30 N ATOM 7630 CA MET A 1054 −15.480 33.193 −3.157 1.00 55.25 C ATOM 7631 CB MET A 1054 −16.754 33.001 −3.888 1.00 61.89 C ATOM 7632 CG MET A 1054 −17.740 32.398 −2.931 1.00 68.91 C ATOM 7633 SD MET A 1054 −19.256 32.483 −3.813 1.00 89.64 S ATOM 7634 CE MET A 1054 −19.010 31.045 −4.885 1.00 86.76 C ATOM 7635 C MET A 1054 −14.508 32.050 −3.397 1.00 50.45 C ATOM 7636 O MET A 1054 −14.514 31.070 −2.656 1.00 48.31 O ATOM 7637 N GLN A 1055 −13.640 32.183 −4.383 1.00 48.02 N ATOM 7638 CA GLN A 1055 −12.529 31.264 −4.488 1.00 48.29 C ATOM 7639 CB GLN A 1055 −11.566 31.731 −5.572 1.00 51.57 C ATOM 7640 CG GLN A 1055 −12.135 31.436 −6.951 1.00 53.12 C ATOM 7641 CD GLN A 1055 −11.136 31.461 −8.088 1.00 54.80 C ATOM 7642 OE1 GLN A 1055 −9.949 31.655 −7.940 1.00 56.67 O ATOM 7643 NE2 GLN A 1055 −11.651 31.288 −9.247 1.00 57.00 N ATOM 7644 C GLN A 1055 −11.812 31.104 −3.147 1.00 46.94 C ATOM 7645 O GLN A 1055 −11.706 29.996 −2.576 1.00 44.09 O ATOM 7646 N ASN A 1056 −11.386 32.238 −2.617 1.00 47.42 N ATOM 7647 CA ASN A 1056 −10.656 32.263 −1.360 1.00 46.32 C ATOM 7648 CB ASN A 1056 −10.223 33.682 −1.001 1.00 47.26 C ATOM 7649 CG ASN A 1056 −9.368 34.336 −2.085 1.00 48.75 C ATOM 7650 OD1 ASN A 1056 −9.376 35.507 −2.207 1.00 51.01 O ATOM 7651 ND2 ASN A 1056 −8.677 33.571 −2.882 1.00 54.66 N ATOM 7652 C ASN A 1056 −11.460 31.654 −0.240 1.00 45.09 C ATOM 7653 O ASN A 1056 −10.943 30.829 0.495 1.00 46.98 O ATOM 7654 N ARG A 1057 −12.729 32.003 −0.118 1.00 43.88 N ATOM 7655 CA ARG A 1057 −13.535 31.367 0.905 1.00 44.92 C ATOM 7656 CB ARG A 1057 −14.975 31.885 0.924 1.00 48.65 C ATOM 7657 CG ARG A 1057 −15.087 33.302 1.473 1.00 52.57 C ATOM 7658 CD ARG A 1057 −16.136 34.140 0.767 1.00 55.20 C ATOM 7659 NE ARG A 1057 −16.206 35.479 1.322 1.00 58.19 N ATOM 7660 CZ ARG A 1057 −16.700 35.794 2.533 1.00 57.70 C ATOM 7661 NH1 ARG A 1057 −17.236 34.897 3.372 1.00 51.75 N ATOM 7662 NH2 ARG A 1057 −16.695 37.073 2.880 1.00 61.11 N ATOM 7663 C ARG A 1057 −13.538 29.891 0.691 1.00 44.42 C ATOM 7664 O ARG A 1057 −13.357 29.149 1.661 1.00 44.75 O ATOM 7665 N LEU A 1058 −13.732 29.465 −0.564 1.00 42.01 N ATOM 7666 CA LEU A 1058 −13.701 28.041 −0.902 1.00 42.09 C ATOM 7667 CB LEU A 1058 −13.952 27.839 −2.387 1.00 44.09 C ATOM 7668 CG LEU A 1058 −15.441 27.916 −2.633 1.00 45.94 C ATOM 7669 CD1 LEU A 1058 −15.703 28.314 −4.076 1.00 46.41 C ATOM 7670 CD2 LEU A 1058 −16.137 26.605 −2.236 1.00 45.22 C ATOM 7671 C LEU A 1058 −12.411 27.324 −0.536 1.00 40.91 C ATOM 7672 O LEU A 1058 −12.435 26.258 0.100 1.00 36.73 O ATOM 7673 N ASN A 1059 −11.283 27.920 −0.898 1.00 38.80 N ATOM 7674 CA ASN A 1059 −10.047 27.291 −0.567 1.00 40.90 C ATOM 7675 CB ASN A 1059 −8.900 28.050 −1.127 1.00 42.59 C ATOM 7676 CG ASN A 1059 −8.947 28.147 −2.617 1.00 44.46 C ATOM 7677 OD1 ASN A 1059 −9.092 27.162 −3.336 1.00 52.81 O ATOM 7678 ND2 ASN A 1059 −8.803 29.333 −3.094 1.00 46.74 N ATOM 7679 C ASN A 1059 −9.815 27.103 0.905 1.00 43.88 C ATOM 7680 O ASN A 1059 −9.076 26.219 1.287 1.00 44.15 O ATOM 7681 N LYS A 1060 −10.410 27.937 1.750 1.00 51.64 N ATOM 7682 CA LYS A 1060 −10.331 27.697 3.208 1.00 56.31 C ATOM 7683 CB LYS A 1060 −10.961 28.810 4.070 1.00 60.73 C ATOM 7684 CG LYS A 1060 −10.231 30.138 4.137 1.00 64.97 C ATOM 7685 CD LYS A 1060 −11.064 31.160 4.916 1.00 72.36 C ATOM 7686 CE LYS A 1060 −10.363 32.504 5.142 1.00 77.47 C ATOM 7687 NZ LYS A 1060 −10.676 33.480 4.056 1.00 79.11 N ATOM 7688 C LYS A 1060 −11.012 26.397 3.562 1.00 52.13 C ATOM 7689 O LYS A 1060 −10.551 25.707 4.450 1.00 56.20 O ATOM 7690 N VAL A 1061 −12.072 26.055 2.845 1.00 48.95 N ATOM 7691 CA VAL A 1061 −13.005 25.003 3.282 1.00 47.62 C ATOM 7692 CB VAL A 1061 −14.432 25.577 3.076 1.00 48.79 C ATOM 7693 CG1 VAL A 1061 −15.290 24.713 2.141 1.00 48.13 C ATOM 7694 CG2 VAL A 1061 −15.105 25.789 4.406 1.00 51.95 C ATOM 7695 C VAL A 1061 −12.881 23.645 2.642 1.00 47.41 C ATOM 7696 O VAL A 1061 −13.368 22.708 3.259 1.00 48.51 O ATOM 7697 N ILE A 1062 −12.287 23.518 1.435 1.00 45.72 N ATOM 7698 CA ILE A 1062 −12.280 22.263 0.607 1.00 45.60 C ATOM 7699 CB ILE A 1062 −12.375 22.602 −0.910 1.00 44.84 C ATOM 7700 CG1 ILE A 1062 −13.796 22.918 −1.287 1.00 47.81 C ATOM 7701 CD1 ILE A 1062 −13.875 24.095 −2.226 1.00 50.68 C ATOM 7702 CG2 ILE A 1062 −11.888 21.517 −1.843 1.00 39.99 C ATOM 7703 C ILE A 1062 −10.995 21.474 0.797 1.00 48.29 C ATOM 7704 O ILE A 1062 −9.924 22.033 0.584 1.00 44.64 O ATOM 7705 N LYS A 1063 −11.096 20.176 1.144 1.00 55.28 N ATOM 7706 CA LYS A 1063 −9.898 19.325 1.321 1.00 58.71 C ATOM 7707 CB LYS A 1063 −10.171 17.980 2.094 1.00 67.62 C ATOM 7708 CG LYS A 1063 −9.085 16.892 1.720 1.00 88.08 C ATOM 7709 CD LYS A 1063 −8.728 15.688 2.659 1.00 95.36 C ATOM 7710 CE LYS A 1063 −7.202 15.302 2.665 1.00 91.60 C ATOM 7711 NZ LYS A 1063 −6.540 14.849 1.383 1.00 84.03 N ATOM 7712 C LYS A 1063 −9.258 19.132 −0.094 1.00 52.18 C ATOM 7713 O LYS A 1063 −9.954 18.902 −1.064 1.00 47.65 O ATOM 7714 N SER A 1064 −7.934 19.266 −0.137 1.00 47.72 N ATOM 7715 CA SER A 1064 −7.086 19.153 −1.317 1.00 41.72 C ATOM 7716 CB SER A 1064 −6.212 20.375 −1.457 1.00 39.50 C ATOM 7717 OG SER A 1064 −5.102 20.122 −2.273 1.00 35.59 O ATOM 7718 C SER A 1064 −6.241 17.950 −1.059 1.00 42.22 C ATOM 7719 O SER A 1064 −5.737 17.788 0.017 1.00 36.54 O ATOM 7720 N VAL A 1065 −6.087 17.096 −2.053 1.00 46.83 N ATOM 7721 CA VAL A 1065 −5.436 15.826 −1.851 1.00 45.71 C ATOM 7722 CB VAL A 1065 −5.573 15.011 −3.131 1.00 43.45 C ATOM 7723 CG1 VAL A 1065 −5.092 13.600 −2.948 1.00 45.12 C ATOM 7724 CG2 VAL A 1065 −7.020 14.956 −3.506 1.00 40.35 C ATOM 7725 C VAL A 1065 −4.016 15.694 −1.353 1.00 49.29 C ATOM 7726 O VAL A 1065 −3.807 14.966 −0.388 1.00 58.69 O ATOM 7727 N GLY A 1066 −3.064 16.400 −1.907 1.00 45.90 N ATOM 7728 CA GLY A 1066 −1.705 16.267 −1.437 1.00 45.11 C ATOM 7729 C GLY A 1066 −1.468 17.485 −0.637 1.00 42.30 C ATOM 7730 O GLY A 1066 −0.376 17.968 −0.560 1.00 42.40 O ATOM 7731 N LYS A 1067 −2.533 18.006 −0.073 1.00 42.56 N ATOM 7732 CA LYS A 1067 −2.465 19.322 0.612 1.00 43.29 C ATOM 7733 CB LYS A 1067 −1.827 19.201 1.998 1.00 46.06 C ATOM 7734 CG LYS A 1067 −2.481 18.113 2.855 1.00 50.02 C ATOM 7735 CD LYS A 1067 −2.714 18.486 4.326 1.00 53.56 C ATOM 7736 CE LYS A 1067 −3.099 17.252 5.148 1.00 56.62 C ATOM 7737 NZ LYS A 1067 −3.031 17.408 6.622 1.00 57.99 N ATOM 7738 C LYS A 1067 −1.799 20.424 −0.208 1.00 41.07 C ATOM 7739 O LYS A 1067 −0.983 21.199 0.265 1.00 40.48 O ATOM 7740 N ILE A 1068 −2.168 20.509 −1.455 1.00 38.58 N ATOM 7741 CA ILE A 1068 −1.522 21.450 −2.297 1.00 40.41 C ATOM 7742 CB ILE A 1068 −1.430 20.919 −3.742 1.00 41.90 C ATOM 7743 CG1 ILE A 1068 −0.631 19.613 −3.783 1.00 39.81 C ATOM 7744 CD1 ILE A 1068 −0.694 18.937 −5.153 1.00 41.22 C ATOM 7745 CG2 ILE A 1068 −0.902 22.019 −4.687 1.00 41.73 C ATOM 7746 C ILE A 1068 −2.361 22.696 −2.298 1.00 41.02 C ATOM 7747 O ILE A 1068 −3.545 22.613 −2.536 1.00 37.79 O ATOM 7748 N GLU A 1069 −1.739 23.855 −2.141 1.00 44.15 N ATOM 7749 CA GLU A 1069 −2.502 25.082 −2.185 1.00 47.04 C ATOM 7750 CB GLU A 1069 −1.662 26.258 −1.713 1.00 53.74 C ATOM 7751 CG GLU A 1069 −1.020 26.157 −0.334 1.00 62.07 C ATOM 7752 CD GLU A 1069 −2.007 26.267 0.811 1.00 69.59 C ATOM 7753 OE1 GLU A 1069 −2.956 27.062 0.686 1.00 76.82 O ATOM 7754 OE2 GLU A 1069 −1.826 25.570 1.844 1.00 75.28 O ATOM 7755 C GLU A 1069 −2.992 25.351 −3.623 1.00 44.38 C ATOM 7756 O GLU A 1069 −2.186 25.483 −4.550 1.00 46.15 O ATOM 7757 N HIS A 1070 −4.305 25.460 −3.804 1.00 40.23 N ATOM 7758 CA HIS A 1070 −4.896 25.972 −5.054 1.00 39.14 C ATOM 7759 CB HIS A 1070 −6.335 26.420 −4.847 1.00 40.21 C ATOM 7760 CG HIS A 1070 −7.040 26.826 −6.101 1.00 42.84 C ATOM 7761 ND1 HIS A 1070 −6.998 28.115 −6.587 1.00 42.67 N ATOM 7762 CE1 HIS A 1070 −7.714 28.179 −7.702 1.00 42.18 C ATOM 7763 NE2 HIS A 1070 −8.209 26.983 −7.961 1.00 41.18 N ATOM 7764 CD2 HIS A 1070 −7.804 26.114 −6.975 1.00 42.94 C ATOM 7765 C HIS A 1070 −4.167 27.121 −5.675 1.00 39.18 C ATOM 7766 O HIS A 1070 −4.121 27.213 −6.840 1.00 37.20 O ATOM 7767 N SER A 1071 −3.624 28.040 −4.907 1.00 47.71 N ATOM 7768 CA SER A 1071 −2.926 29.224 −5.515 1.00 50.50 C ATOM 7769 CB SER A 1071 −2.824 30.367 −4.519 1.00 49.64 C ATOM 7770 OG SER A 1071 −4.112 30.950 −4.452 1.00 51.51 O ATOM 7771 C SER A 1071 −1.565 28.895 −6.120 1.00 48.11 C ATOM 7772 O SER A 1071 −1.187 29.427 −7.169 1.00 48.92 O ATOM 7773 N PHE A 1072 −0.861 27.991 −5.463 1.00 44.44 N ATOM 7774 CA PHE A 1072 0.349 27.466 −5.997 1.00 42.39 C ATOM 7775 CB PHE A 1072 0.948 26.462 −5.018 1.00 40.30 C ATOM 7776 CG PHE A 1072 2.178 25.834 −5.516 1.00 39.69 C ATOM 7777 CD1 PHE A 1072 3.353 26.488 −5.452 1.00 40.45 C ATOM 7778 CE1 PHE A 1072 4.508 25.937 −5.944 1.00 42.92 C ATOM 7779 CZ PHE A 1072 4.480 24.701 −6.512 1.00 43.61 C ATOM 7780 CE2 PHE A 1072 3.284 24.021 −6.582 1.00 42.77 C ATOM 7781 CD2 PHE A 1072 2.145 24.599 −6.091 1.00 42.02 C ATOM 7782 C PHE A 1072 0.050 26.819 −7.338 1.00 44.50 C ATOM 7783 O PHE A 1072 0.795 27.041 −8.335 1.00 45.18 O ATOM 7784 N TRP A 1073 −1.035 26.023 −7.335 1.00 42.76 N ATOM 7785 CA TRP A 1073 −1.435 25.262 −8.503 1.00 41.77 C ATOM 7786 CB TRP A 1073 −2.606 24.349 −8.194 1.00 40.61 C ATOM 7787 CG TRP A 1073 −3.341 23.727 −9.364 1.00 41.13 C ATOM 7788 CD1 TRP A 1073 −4.678 23.762 −9.562 1.00 43.82 C ATOM 7789 NE1 TRP A 1073 −5.027 23.083 −10.728 1.00 42.21 N ATOM 7790 CE2 TRP A 1073 −3.882 22.558 −11.269 1.00 40.00 C ATOM 7791 CD2 TRP A 1073 −2.802 22.954 −10.450 1.00 39.89 C ATOM 7792 CE3 TRP A 1073 −1.521 22.574 −10.820 1.00 39.11 C ATOM 7793 CZ3 TRP A 1073 −1.365 21.815 −11.962 1.00 37.89 C ATOM 7794 CH2 TRP A 1073 −2.465 21.435 −12.746 1.00 36.90 C ATOM 7795 CZ2 TRP A 1073 −3.710 21.794 −12.430 1.00 37.19 C ATOM 7796 C TRP A 1073 −1.744 26.180 −9.651 1.00 41.63 C ATOM 7797 O TRP A 1073 −1.157 26.040 −10.699 1.00 42.97 O ATOM 7798 N ARG A 1074 −2.590 27.170 −9.448 1.00 41.38 N ATOM 7799 CA ARG A 1074 −2.990 28.024 −10.569 1.00 43.29 C ATOM 7800 CB ARG A 1074 −4.382 28.574 −10.368 1.00 42.95 C ATOM 7801 CG ARG A 1074 −5.426 27.495 −10.164 1.00 42.96 C ATOM 7802 CD ARG A 1074 −5.435 26.628 −11.382 1.00 44.53 C ATOM 7803 NE ARG A 1074 −6.752 26.090 −11.673 1.00 44.66 N ATOM 7804 CZ ARG A 1074 −6.992 25.297 −12.699 1.00 40.18 C ATOM 7805 NH1 ARG A 1074 −6.049 24.952 −13.551 1.00 40.05 N ATOM 7806 NH2 ARG A 1074 −8.198 24.908 −12.905 1.00 40.79 N ATOM 7807 C ARG A 1074 −2.022 29.128 −10.917 1.00 43.87 C ATOM 7808 O ARG A 1074 −2.309 29.958 −11.763 1.00 40.11 O ATOM 7809 N SER A 1075 −0.839 29.077 −10.339 1.00 47.62 N ATOM 7810 CA SER A 1075 0.119 30.116 −10.564 1.00 49.67 C ATOM 7811 CB SER A 1075 1.192 30.124 −9.477 1.00 52.21 C ATOM 7812 OG SER A 1075 0.704 30.814 −8.347 1.00 53.19 O ATOM 7813 C SER A 1075 0.759 29.875 −11.882 1.00 47.06 C ATOM 7814 O SER A 1075 1.249 28.792 −12.138 1.00 44.35 O ATOM 7815 N PHE A 1076 0.740 30.918 −12.696 1.00 48.12 N ATOM 7816 CA PHE A 1076 1.469 30.979 −13.928 1.00 50.95 C ATOM 7817 CB PHE A 1076 1.478 32.392 −14.475 1.00 50.87 C ATOM 7818 CG PHE A 1076 2.078 32.510 −15.835 1.00 53.54 C ATOM 7819 CD1 PHE A 1076 3.455 32.515 −16.005 1.00 56.47 C ATOM 7820 CE1 PHE A 1076 4.013 32.625 −17.270 1.00 56.75 C ATOM 7821 CZ PHE A 1076 3.190 32.748 −18.369 1.00 55.42 C ATOM 7822 CE2 PHE A 1076 1.822 32.728 −18.213 1.00 53.96 C ATOM 7823 CD2 PHE A 1076 1.269 32.610 −16.958 1.00 54.19 C ATOM 7824 C PHE A 1076 2.849 30.588 −13.599 1.00 54.20 C ATOM 7825 O PHE A 1076 3.437 31.218 −12.777 1.00 53.54 O ATOM 7826 N HIS A 1077 3.350 29.555 −14.264 1.00 68.19 N ATOM 7827 CA HIS A 1077 4.620 28.922 −13.922 1.00 82.28 C ATOM 7828 CB HIS A 1077 4.313 27.640 −13.113 1.00 91.48 C ATOM 7829 CG HIS A 1077 5.343 26.559 −13.255 1.00 100.86 C ATOM 7830 ND1 HIS A 1077 6.562 26.601 −12.607 1.00 101.07 N ATOM 7831 CE1 HIS A 1077 7.262 25.526 −12.930 1.00 104.05 C ATOM 7832 NE2 HIS A 1077 6.541 24.787 −13.757 1.00 104.74 N ATOM 7833 CD2 HIS A 1077 5.338 25.414 −13.985 1.00 102.26 C ATOM 7834 C HIS A 1077 5.449 28.601 −15.188 1.00 80.93 C ATOM 7835 O HIS A 1077 4.864 28.263 −16.216 1.00 65.95 O ATOM 7836 N THR A 1078 6.791 28.704 −15.071 1.00 83.40 N ATOM 7837 CA THR A 1078 7.765 28.188 −16.061 1.00 80.77 C ATOM 7838 CB THR A 1078 8.403 29.342 −16.860 1.00 79.58 C ATOM 7839 OG1 THR A 1078 9.130 30.200 −15.964 1.00 85.17 O ATOM 7840 CG2 THR A 1078 7.323 30.137 −17.579 1.00 74.66 C ATOM 7841 C THR A 1078 8.844 27.280 −15.395 1.00 79.77 C ATOM 7842 O THR A 1078 9.991 27.673 −15.121 1.00 81.29 O ATOM 7843 N LYS A 1081 10.270 32.522 −14.088 1.00 105.66 N ATOM 7844 CA LYS A 1081 9.051 33.117 −13.546 1.00 99.63 C ATOM 7845 CB LYS A 1081 8.193 33.779 −14.665 1.00 90.33 C ATOM 7846 C LYS A 1081 8.257 32.036 −12.780 1.00 96.09 C ATOM 7847 O LYS A 1081 8.360 30.826 −13.108 1.00 80.17 O ATOM 7848 N THR A 1082 7.572 32.499 −11.709 1.00 96.29 N ATOM 7849 CA THR A 1082 6.312 31.912 −11.138 1.00 87.28 C ATOM 7850 CB THR A 1082 6.553 30.786 −10.099 1.00 85.28 C ATOM 7851 OG1 THR A 1082 7.585 29.916 −10.552 1.00 90.82 O ATOM 7852 CG2 THR A 1082 5.309 29.933 −9.910 1.00 87.86 C ATOM 7853 C THR A 1082 5.462 33.020 −10.475 1.00 76.73 C ATOM 7854 O THR A 1082 5.811 33.484 −9.400 1.00 78.96 O ATOM 7855 N GLU A 1083 4.380 33.459 −11.119 1.00 71.55 N ATOM 7856 CA GLU A 1083 3.531 34.553 −10.584 1.00 75.19 C ATOM 7857 CB GLU A 1083 3.415 35.732 −11.571 1.00 83.76 C ATOM 7858 CG GLU A 1083 4.656 36.050 −12.398 1.00 95.44 C ATOM 7859 CD GLU A 1083 4.578 37.399 −13.139 1.00 110.55 C ATOM 7860 OE1 GLU A 1083 3.958 38.356 −12.600 1.00 124.78 O ATOM 7861 OE2 GLU A 1083 5.161 37.522 −14.257 1.00 116.47 O ATOM 7862 C GLU A 1083 2.097 34.104 −10.254 1.00 67.06 C ATOM 7863 O GLU A 1083 1.529 33.278 −10.943 1.00 57.65 O ATOM 7864 N PRO A 1084 1.490 34.674 −9.201 1.00 65.64 N ATOM 7865 CA PRO A 1084 0.058 34.518 −9.010 1.00 62.63 C ATOM 7866 CB PRO A 1084 −0.249 35.614 −7.981 1.00 61.65 C ATOM 7867 CG PRO A 1084 0.902 35.486 −7.059 1.00 63.98 C ATOM 7868 CD PRO A 1084 2.103 35.121 −7.937 1.00 66.21 C ATOM 7869 C PRO A 1084 −0.774 34.713 −10.256 1.00 55.41 C ATOM 7870 O PRO A 1084 −0.444 35.552 −11.082 1.00 55.98 O ATOM 7871 N ALA A 1085 −1.840 33.929 −10.359 1.00 49.46 N ATOM 7872 CA ALA A 1085 −2.754 34.022 −11.475 1.00 47.05 C ATOM 7873 CB ALA A 1085 −3.621 32.792 −11.611 1.00 47.39 C ATOM 7874 C ALA A 1085 −3.630 35.166 −11.254 1.00 48.28 C ATOM 7875 O ALA A 1085 −3.931 35.495 −10.125 1.00 45.88 O ATOM 7876 N THR A 1086 −4.113 35.705 −12.372 1.00 51.63 N ATOM 7877 CA THR A 1086 −4.839 36.951 −12.412 1.00 49.60 C ATOM 7878 CB THR A 1086 −3.852 38.144 −12.417 1.00 51.61 C ATOM 7879 OG1 THR A 1086 −4.327 39.136 −13.324 1.00 64.43 O ATOM 7880 CG2 THR A 1086 −2.413 37.778 −12.873 1.00 51.07 C ATOM 7881 C THR A 1086 −5.836 37.032 −13.591 1.00 49.78 C ATOM 7882 O THR A 1086 −5.528 36.789 −14.774 1.00 50.34 O ATOM 7883 N GLY A 1087 −7.054 37.411 −13.269 1.00 51.36 N ATOM 7884 CA GLY A 1087 −8.009 37.774 −14.319 1.00 52.41 C ATOM 7885 C GLY A 1087 −8.651 36.569 −14.919 1.00 52.13 C ATOM 7886 O GLY A 1087 −9.209 36.645 −16.000 1.00 53.29 O ATOM 7887 N PHE A 1088 −8.587 35.480 −14.150 1.00 53.49 N ATOM 7888 CA PHE A 1088 −9.135 34.186 −14.465 1.00 50.63 C ATOM 7889 CB PHE A 1088 −8.019 33.242 −14.876 1.00 51.67 C ATOM 7890 CG PHE A 1088 −7.684 33.341 −16.312 1.00 52.51 C ATOM 7891 CD1 PHE A 1088 −8.519 32.777 −17.242 1.00 49.88 C ATOM 7892 CE1 PHE A 1088 −8.274 32.864 −18.571 1.00 48.71 C ATOM 7893 CZ PHE A 1088 −7.178 33.531 −18.997 1.00 51.60 C ATOM 7894 CE2 PHE A 1088 −6.324 34.114 −18.075 1.00 55.30 C ATOM 7895 CD2 PHE A 1088 −6.596 34.039 −16.733 1.00 53.66 C ATOM 7896 C PHE A 1088 −9.781 33.613 −13.241 1.00 48.35 C ATOM 7897 O PHE A 1088 −9.112 33.436 −12.189 1.00 43.06 O ATOM 7898 N ILE A 1089 −11.060 33.295 −13.366 1.00 47.78 N ATOM 7899 CA ILE A 1089 −11.699 32.532 −12.319 1.00 48.72 C ATOM 7900 CB ILE A 1089 −13.050 33.116 −11.984 1.00 53.95 C ATOM 7901 CG1 ILE A 1089 −12.813 34.281 −11.006 1.00 57.73 C ATOM 7902 CD1 ILE A 1089 −13.865 35.332 −11.085 1.00 60.48 C ATOM 7903 CG2 ILE A 1089 −13.997 32.081 −11.374 1.00 55.61 C ATOM 7904 C ILE A 1089 −11.764 31.072 −12.669 1.00 47.00 C ATOM 7905 O ILE A 1089 −12.235 30.699 −13.760 1.00 46.06 O ATOM 7906 N ASP A 1090 −11.174 30.269 −11.782 1.00 42.60 N ATOM 7907 CA ASP A 1090 −11.271 28.822 −11.833 1.00 40.79 C ATOM 7908 CB ASP A 1090 −10.328 28.135 −10.812 1.00 40.70 C ATOM 7909 CG ASP A 1090 −10.212 26.620 −11.035 1.00 44.64 C ATOM 7910 OD1 ASP A 1090 −10.887 26.035 −11.970 1.00 46.49 O ATOM 7911 OD2 ASP A 1090 −9.430 26.006 −10.281 1.00 45.76 O ATOM 7912 C ASP A 1090 −12.686 28.352 −11.647 1.00 38.31 C ATOM 7913 O ASP A 1090 −13.083 28.013 −10.550 1.00 41.10 O ATOM 7914 N GLY A 1091 −13.433 28.300 −12.730 1.00 36.39 N ATOM 7915 CA GLY A 1091 −14.786 27.778 −12.702 1.00 36.94 C ATOM 7916 C GLY A 1091 −14.918 26.382 −12.099 1.00 37.95 C ATOM 7917 O GLY A 1091 −15.934 26.079 −11.454 1.00 36.21 O ATOM 7918 N ASP A 1092 −13.906 25.530 −12.283 1.00 39.74 N ATOM 7919 CA ASP A 1092 −13.959 24.229 −11.634 1.00 42.54 C ATOM 7920 CB ASP A 1092 −12.815 23.323 −12.081 1.00 48.47 C ATOM 7921 CG ASP A 1092 −13.014 22.723 −13.506 1.00 51.81 C ATOM 7922 OD1 ASP A 1092 −14.140 22.766 −14.086 1.00 51.55 O ATOM 7923 OD2 ASP A 1092 −11.990 22.181 −14.018 1.00 56.24 O ATOM 7924 C ASP A 1092 −13.988 24.343 −10.102 1.00 41.48 C ATOM 7925 O ASP A 1092 −14.745 23.652 −9.432 1.00 38.30 O ATOM 7926 N LEU A 1093 −13.194 25.241 −9.544 1.00 43.89 N ATOM 7927 CA LEU A 1093 −13.269 25.519 −8.112 1.00 44.43 C ATOM 7928 CB LEU A 1093 −12.256 26.568 −7.738 1.00 47.53 C ATOM 7929 CG LEU A 1093 −12.201 27.041 −6.282 1.00 52.35 C ATOM 7930 CD1 LEU A 1093 −11.904 25.865 −5.371 1.00 52.94 C ATOM 7931 CD2 LEU A 1093 −11.160 28.170 −6.138 1.00 53.99 C ATOM 7932 C LEU A 1093 −14.652 26.014 −7.737 1.00 43.21 C ATOM 7933 O LEU A 1093 −15.293 25.458 −6.787 1.00 42.56 O ATOM 7934 N ILE A 1094 −15.105 27.041 −8.467 1.00 38.42 N ATOM 7935 CA ILE A 1094 −16.337 27.674 −8.123 1.00 39.18 C ATOM 7936 CB ILE A 1094 −16.686 28.798 −9.059 1.00 39.83 C ATOM 7937 CG1 ILE A 1094 −15.765 29.982 −8.845 1.00 40.43 C ATOM 7938 CD1 ILE A 1094 −16.038 30.745 −7.582 1.00 42.87 C ATOM 7939 CG2 ILE A 1094 −18.152 29.203 −8.912 1.00 40.34 C ATOM 7940 C ILE A 1094 −17.455 26.650 −8.152 1.00 43.93 C ATOM 7941 O ILE A 1094 −18.243 26.602 −7.204 1.00 43.36 O ATOM 7942 N GLU A 1095 −17.533 25.827 −9.212 1.00 46.47 N ATOM 7943 CA GLU A 1095 −18.572 24.788 −9.258 1.00 46.63 C ATOM 7944 CB GLU A 1095 −18.595 24.039 −10.597 1.00 51.50 C ATOM 7945 CG GLU A 1095 −19.030 24.893 −11.793 1.00 57.97 C ATOM 7946 CD GLU A 1095 −19.107 24.171 −13.187 1.00 59.84 C ATOM 7947 OE1 GLU A 1095 −18.893 22.894 −13.212 1.00 56.16 O ATOM 7948 OE2 GLU A 1095 −19.373 24.945 −14.226 1.00 52.70 O ATOM 7949 C GLU A 1095 −18.466 23.792 −8.075 1.00 46.45 C ATOM 7950 O GLU A 1095 −19.477 23.321 −7.647 1.00 43.40 O ATOM 7951 N SER A 1096 −17.286 23.481 −7.524 1.00 47.97 N ATOM 7952 CA SER A 1096 −17.225 22.565 −6.347 1.00 50.09 C ATOM 7953 CB SER A 1096 −15.788 22.256 −5.830 1.00 50.49 C ATOM 7954 OG SER A 1096 −15.097 23.399 −5.343 1.00 48.11 O ATOM 7955 C SER A 1096 −18.055 23.071 −5.180 1.00 51.90 C ATOM 7956 O SER A 1096 −18.557 22.261 −4.421 1.00 52.68 O ATOM 7957 N PHE A 1097 −18.245 24.379 −5.023 1.00 50.47 N ATOM 7958 CA PHE A 1097 −19.186 24.830 −3.979 1.00 55.22 C ATOM 7959 CB PHE A 1097 −19.685 26.243 −4.272 1.00 59.43 C ATOM 7960 CG PHE A 1097 −20.723 26.750 −3.308 1.00 58.07 C ATOM 7961 CD1 PHE A 1097 −22.052 26.523 −3.529 1.00 58.08 C ATOM 7962 CE1 PHE A 1097 −23.011 27.008 −2.662 1.00 59.15 C ATOM 7963 CZ PHE A 1097 −22.633 27.726 −1.569 1.00 58.76 C ATOM 7964 CE2 PHE A 1097 −21.298 27.955 −1.340 1.00 61.11 C ATOM 7965 CD2 PHE A 1097 −20.355 27.470 −2.208 1.00 60.73 C ATOM 7966 C PHE A 1097 −20.410 23.922 −3.778 1.00 55.88 C ATOM 7967 O PHE A 1097 −20.756 23.618 −2.654 1.00 57.58 O ATOM 7968 N LEU A 1098 −21.052 23.507 −4.881 1.00 58.62 N ATOM 7969 CA LEU A 1098 −22.267 22.636 −4.873 1.00 53.73 C ATOM 7970 CB LEU A 1098 −22.856 22.458 −6.267 1.00 50.33 C ATOM 7971 CG LEU A 1098 −23.180 23.738 −7.025 1.00 52.85 C ATOM 7972 CD1 LEU A 1098 −23.563 23.412 −8.448 1.00 57.84 C ATOM 7973 CD2 LEU A 1098 −24.301 24.537 −6.429 1.00 53.12 C ATOM 7974 C LEU A 1098 −22.057 21.258 −4.240 1.00 51.60 C ATOM 7975 O LEU A 1098 −23.034 20.642 −3.808 1.00 52.46 O ATOM 7976 N ASP A 1099 −20.818 20.798 −4.144 1.00 49.53 N ATOM 7977 CA ASP A 1099 −20.521 19.501 −3.548 1.00 55.77 C ATOM 7978 CB ASP A 1099 −19.357 18.847 −4.304 1.00 61.18 C ATOM 7979 CG ASP A 1099 −19.598 18.767 −5.786 1.00 67.70 C ATOM 7980 OD1 ASP A 1099 −20.753 18.404 −6.154 1.00 68.10 O ATOM 7981 OD2 ASP A 1099 −18.635 19.071 −6.565 1.00 73.99 O ATOM 7982 C ASP A 1099 −20.131 19.542 −2.071 1.00 56.30 C ATOM 7983 O ASP A 1099 −19.780 18.519 −1.513 1.00 60.65 O ATOM 7984 N ILE A 1100 −20.136 20.700 −1.425 1.00 55.68 N ATOM 7985 CA ILE A 1100 −19.691 20.765 −0.022 1.00 53.95 C ATOM 7986 CB ILE A 1100 −18.819 22.044 0.233 1.00 51.56 C ATOM 7987 CG1 ILE A 1100 −19.651 23.351 0.405 1.00 51.21 C ATOM 7988 CD1 ILE A 1100 −18.904 24.685 0.280 1.00 48.28 C ATOM 7989 CG2 ILE A 1100 −17.838 22.206 −0.909 1.00 51.36 C ATOM 7990 C ILE A 1100 −20.940 20.605 0.885 1.00 55.28 C ATOM 7991 O ILE A 1100 −22.046 21.033 0.490 1.00 55.63 O ATOM 7992 N SER A 1101 −20.782 19.985 2.061 1.00 52.03 N ATOM 7993 CA SER A 1101 −21.863 19.974 3.045 1.00 53.01 C ATOM 7994 CB SER A 1101 −21.419 19.360 4.381 1.00 57.28 C ATOM 7995 OG SER A 1101 −20.511 20.162 5.106 1.00 56.94 O ATOM 7996 C SER A 1101 −22.492 21.347 3.309 1.00 51.74 C ATOM 7997 O SER A 1101 −21.846 22.371 3.266 1.00 47.35 O ATOM 7998 N ARG A 1102 −23.788 21.333 3.566 1.00 55.36 N ATOM 7999 CA ARG A 1102 −24.573 22.539 3.880 1.00 59.79 C ATOM 8000 CB ARG A 1102 −25.965 22.076 4.374 1.00 62.67 C ATOM 8001 CG ARG A 1102 −26.958 23.147 4.792 1.00 65.82 C ATOM 8002 CD ARG A 1102 −27.842 23.578 3.638 1.00 70.44 C ATOM 8003 NE ARG A 1102 −28.401 24.887 3.952 1.00 80.50 N ATOM 8004 CZ ARG A 1102 −28.941 25.721 3.064 1.00 86.50 C ATOM 8005 NH1 ARG A 1102 −29.046 25.371 1.768 1.00 87.09 N ATOM 8006 NH2 ARG A 1102 −29.387 26.914 3.486 1.00 83.68 N ATOM 8007 C ARG A 1102 −23.914 23.489 4.930 1.00 59.79 C ATOM 8008 O ARG A 1102 −24.056 24.728 4.834 1.00 55.92 O ATOM 8009 N PRO A 1103 −23.261 22.914 5.975 1.00 58.05 N ATOM 8010 CA PRO A 1103 −22.568 23.807 6.849 1.00 57.76 C ATOM 8011 CB PRO A 1103 −22.304 22.961 8.096 1.00 58.11 C ATOM 8012 CG PRO A 1103 −22.491 21.579 7.674 1.00 57.13 C ATOM 8013 CD PRO A 1103 −23.554 21.648 6.666 1.00 58.50 C ATOM 8014 C PRO A 1103 −21.314 24.407 6.225 1.00 59.22 C ATOM 8015 O PRO A 1103 −21.105 25.599 6.438 1.00 68.40 O ATOM 8016 N LYS A 1104 −20.531 23.682 5.417 1.00 61.04 N ATOM 8017 CA LYS A 1104 −19.365 24.333 4.743 1.00 59.39 C ATOM 8018 CB LYS A 1104 −18.444 23.388 3.983 1.00 58.42 C ATOM 8019 CG LYS A 1104 −17.976 22.159 4.704 1.00 63.33 C ATOM 8020 CD LYS A 1104 −17.193 22.477 5.943 1.00 73.40 C ATOM 8021 CE LYS A 1104 −15.723 22.150 5.803 1.00 82.84 C ATOM 8022 NZ LYS A 1104 −14.985 22.805 6.943 1.00 94.96 N ATOM 8023 C LYS A 1104 −19.848 25.437 3.793 1.00 60.11 C ATOM 8024 O LYS A 1104 −19.147 26.429 3.638 1.00 62.27 O ATOM 8025 N MET A 1105 −21.029 25.297 3.173 1.00 59.62 N ATOM 8026 CA MET A 1105 −21.583 26.417 2.400 1.00 61.10 C ATOM 8027 CB MET A 1105 −22.928 26.117 1.756 1.00 65.26 C ATOM 8028 CG MET A 1105 −22.799 25.209 0.563 1.00 73.41 C ATOM 8029 SD MET A 1105 −24.348 24.885 −0.287 1.00 77.03 S ATOM 8030 CE MET A 1105 −24.261 23.104 −0.223 1.00 75.35 C ATOM 8031 C MET A 1105 −21.743 27.586 3.303 1.00 57.05 C ATOM 8032 O MET A 1105 −21.277 28.674 2.976 1.00 60.32 O ATOM 8033 N GLN A 1106 −22.370 27.337 4.449 1.00 55.04 N ATOM 8034 CA GLN A 1106 −22.778 28.395 5.356 1.00 54.56 C ATOM 8035 CB GLN A 1106 −23.582 27.833 6.527 1.00 58.78 C ATOM 8036 CG GLN A 1106 −25.059 28.253 6.474 1.00 65.71 C ATOM 8037 CD GLN A 1106 −26.076 27.113 6.650 1.00 70.50 C ATOM 8038 OE1 GLN A 1106 −25.851 26.112 7.369 1.00 67.08 O ATOM 8039 NE2 GLN A 1106 −27.238 27.290 6.004 1.00 74.11 N ATOM 8040 C GLN A 1106 −21.566 29.206 5.764 1.00 52.05 C ATOM 8041 O GLN A 1106 −21.608 30.457 5.703 1.00 50.89 O ATOM 8042 N GLU A 1107 −20.517 28.485 6.078 1.00 47.40 N ATOM 8043 CA GLU A 1107 −19.259 29.009 6.499 1.00 48.27 C ATOM 8044 CB GLU A 1107 −18.347 27.822 6.702 1.00 50.20 C ATOM 8045 CG GLU A 1107 −17.147 28.040 7.574 1.00 53.68 C ATOM 8046 CD GLU A 1107 −16.427 26.754 7.861 1.00 60.36 C ATOM 8047 OE1 GLU A 1107 −15.198 26.748 7.786 1.00 67.92 O ATOM 8048 OE2 GLU A 1107 −17.074 25.746 8.162 1.00 56.10 O ATOM 8049 C GLU A 1107 −18.696 29.847 5.407 1.00 50.72 C ATOM 8050 O GLU A 1107 −18.132 30.887 5.631 1.00 48.51 O ATOM 8051 N VAL A 1108 −18.842 29.376 4.195 1.00 56.40 N ATOM 8052 CA VAL A 1108 −18.295 30.071 3.054 1.00 58.32 C ATOM 8053 CB VAL A 1108 −18.469 29.231 1.799 1.00 57.48 C ATOM 8054 CG1 VAL A 1108 −17.830 29.907 0.623 1.00 60.91 C ATOM 8055 CG2 VAL A 1108 −17.824 27.894 2.003 1.00 57.29 C ATOM 8056 C VAL A 1108 −18.873 31.432 2.796 1.00 56.80 C ATOM 8057 O VAL A 1108 −18.163 32.348 2.457 1.00 49.65 O ATOM 8058 N VAL A 1109 −20.169 31.559 2.948 1.00 58.50 N ATOM 8059 CA VAL A 1109 −20.816 32.817 2.683 1.00 71.11 C ATOM 8060 CB VAL A 1109 −22.187 32.579 2.083 1.00 71.10 C ATOM 8061 CG1 VAL A 1109 −22.050 31.611 0.948 1.00 75.45 C ATOM 8062 CG2 VAL A 1109 −23.093 31.971 3.111 1.00 76.57 C ATOM 8063 C VAL A 1109 −20.970 33.708 3.895 1.00 82.67 C ATOM 8064 O VAL A 1109 −21.576 34.768 3.810 1.00 89.35 O ATOM 8065 N ALA A 1110 −20.423 33.292 5.021 1.00 82.51 N ATOM 8066 CA ALA A 1110 −20.574 34.073 6.214 1.00 83.79 C ATOM 8067 CB ALA A 1110 −19.743 33.460 7.304 1.00 89.35 C ATOM 8068 C ALA A 1110 −20.099 35.469 5.963 1.00 83.79 C ATOM 8069 O ALA A 1110 −19.004 35.689 5.502 1.00 93.17 O ATOM 8070 N ASN A 1111 −20.954 36.417 6.297 1.00 86.51 N ATOM 8071 CA ASN A 1111 −20.672 37.833 6.139 1.00 91.87 C ATOM 8072 CB ASN A 1111 −19.711 38.353 7.192 1.00 98.48 C ATOM 8073 CG ASN A 1111 −19.906 39.830 7.448 1.00 106.05 C ATOM 8074 OD1 ASN A 1111 −18.956 40.564 7.707 1.00 110.53 O ATOM 8075 ND2 ASN A 1111 −21.150 40.279 7.356 1.00 106.80 N ATOM 8076 C ASN A 1111 −20.220 38.234 4.755 1.00 80.65 C ATOM 8077 O ASN A 1111 −19.293 39.002 4.604 1.00 72.66 O ATOM 8078 N LEU A 1112 −20.886 37.712 3.745 1.00 81.43 N ATOM 8079 CA LEU A 1112 −20.513 38.037 2.399 1.00 85.59 C ATOM 8080 CB LEU A 1112 −20.627 36.797 1.542 1.00 87.44 C ATOM 8081 CG LEU A 1112 −19.662 36.780 0.371 1.00 90.11 C ATOM 8082 CD1 LEU A 1112 −20.044 35.697 −0.609 1.00 88.37 C ATOM 8083 CD2 LEU A 1112 −19.605 38.134 −0.300 1.00 88.02 C ATOM 8084 C LEU A 1112 −21.450 39.049 1.835 1.00 92.93 C ATOM 8085 O LEU A 1112 −22.625 38.771 1.686 1.00 98.85 O ATOM 8086 N GLN A 1113 −20.941 40.223 1.489 1.00 96.92 N ATOM 8087 CA GLN A 1113 −21.816 41.248 0.900 1.00 97.38 C ATOM 8088 CB GLN A 1113 −21.189 42.663 1.029 1.00 87.49 C ATOM 8089 C GLN A 1113 −22.213 40.779 −0.566 1.00 93.07 C ATOM 8090 O GLN A 1113 −21.399 40.220 −1.296 1.00 74.53 O ATOM 8091 N TYR A 1114 −23.489 40.934 −0.930 1.00 96.50 N ATOM 8092 CA TYR A 1114 −24.036 40.364 −2.176 1.00 99.31 C ATOM 8093 CB TYR A 1114 −24.441 38.935 −1.904 1.00 94.19 C ATOM 8094 CG TYR A 1114 −25.161 38.224 −3.014 1.00 88.63 C ATOM 8095 CD1 TYR A 1114 −24.633 38.145 −4.284 1.00 86.48 C ATOM 8096 CE1 TYR A 1114 −25.301 37.455 −5.298 1.00 87.77 C ATOM 8097 CZ TYR A 1114 −26.499 36.791 −5.020 1.00 88.67 C ATOM 8098 OH TYR A 1114 −27.207 36.073 −5.978 1.00 76.59 O ATOM 8099 CE2 TYR A 1114 −27.013 36.846 −3.744 1.00 90.71 C ATOM 8100 CD2 TYR A 1114 −26.350 37.560 −2.761 1.00 90.76 C ATOM 8101 C TYR A 1114 −25.218 41.191 −2.693 1.00 104.75 C ATOM 8102 O TYR A 1114 −26.037 41.654 −1.908 1.00 101.29 O ATOM 8103 N ASP A 1115 −25.282 41.365 −4.017 1.00 117.43 N ATOM 8104 CA ASP A 1115 −26.043 42.463 −4.666 1.00 121.03 C ATOM 8105 CB ASP A 1115 −25.325 42.962 −5.944 1.00 127.29 C ATOM 8106 CG ASP A 1115 −23.849 43.375 −5.704 1.00 129.49 C ATOM 8107 OD1 ASP A 1115 −23.065 42.594 −5.106 1.00 119.77 O ATOM 8108 OD2 ASP A 1115 −23.467 44.479 −6.158 1.00 128.53 O ATOM 8109 C ASP A 1115 −27.475 42.088 −5.047 1.00 114.55 C ATOM 8110 O ASP A 1115 −27.768 40.898 −5.282 1.00 99.72 O ATOM 8111 N ASP A 1116 −28.297 43.153 −5.161 1.00 114.84 N ATOM 8112 CA ASP A 1116 −29.804 43.185 −5.282 1.00 115.28 C ATOM 8113 CB ASP A 1116 −30.500 41.835 −4.916 1.00 107.27 C ATOM 8114 CG ASP A 1116 −30.312 40.734 −5.973 1.00 94.60 C ATOM 8115 OD1 ASP A 1116 −30.480 41.020 −7.177 1.00 77.14 O ATOM 8116 OD2 ASP A 1116 −29.998 39.587 −5.566 1.00 81.68 O ATOM 8117 C ASP A 1116 −30.366 44.337 −4.362 1.00 110.43 C ATOM 8118 O ASP A 1116 −31.003 45.321 −4.792 1.00 90.27 O ATOM 8119 N LYS A 1121 −25.845 46.114 −0.932 1.00 120.25 N ATOM 8120 CA LYS A 1121 −25.757 44.660 −0.714 1.00 129.35 C ATOM 8121 CB LYS A 1121 −24.292 44.211 −0.910 1.00 126.25 C ATOM 8122 C LYS A 1121 −26.337 44.225 0.684 1.00 124.02 C ATOM 8123 O LYS A 1121 −26.803 45.085 1.441 1.00 110.93 O ATOM 8124 N ARG 1122 −26.346 42.912 0.985 1.00 119.73 N ATOM 8125 CA ARG 1122 −26.673 42.365 2.342 1.00 125.56 C ATOM 8126 CB ARG 1122 −28.216 42.272 2.580 1.00 134.15 C ATOM 8127 CG ARG 1122 −29.075 41.696 1.442 1.00 134.87 C ATOM 8128 CD ARG 1122 −29.883 40.427 1.755 1.00 128.57 C ATOM 8129 NE ARG 1122 −29.573 39.356 0.789 1.00 137.32 N ATOM 8130 CZ ARG 1122 −29.856 39.355 −0.530 1.00 138.94 C ATOM 8131 NH1 ARG 1122 −29.495 38.311 −1.285 1.00 127.82 N ATOM 8132 NH2 ARG 1122 −30.488 40.376 −1.122 1.00 141.69 N ATOM 8133 C ARG 1122 −25.968 41.008 2.650 1.00 126.60 C ATOM 8134 O ARG 1122 −25.315 40.441 1.764 1.00 128.12 O ATOM 8135 N GLU A 1123 −26.080 40.517 3.902 1.00 125.41 N ATOM 8136 CA GLU A 1123 −25.534 39.190 4.317 1.00 116.81 C ATOM 8137 CB GLU A 1123 −25.473 39.007 5.852 1.00 107.54 C ATOM 8138 C GLU A 1123 −26.342 38.063 3.633 1.00 114.45 C ATOM 8139 O GLU A 1123 −27.594 37.945 3.793 1.00 98.66 O ATOM 8140 N ALA A 1124 −25.580 37.258 2.876 1.00 108.84 N ATOM 8141 CA ALA A 1124 −26.072 36.389 1.797 1.00 93.41 C ATOM 8142 CB ALA A 1124 −25.096 36.443 0.639 1.00 88.14 C ATOM 8143 C ALA A 1124 −26.225 34.962 2.290 1.00 83.68 C ATOM 8144 O ALA A 1124 −25.523 34.547 3.198 1.00 79.13 O ATOM 8145 N THR A 1125 −27.146 34.217 1.702 1.00 77.96 N ATOM 8146 CA THR A 1125 −27.439 32.861 2.192 1.00 80.33 C ATOM 8147 CB THR A 1125 −28.962 32.610 2.368 1.00 82.35 C ATOM 8148 OG1 THR A 1125 −29.474 31.899 1.242 1.00 88.87 O ATOM 8149 CG2 THR A 1125 −29.764 33.923 2.568 1.00 81.94 C ATOM 8150 C THR A 1125 −26.788 31.723 1.356 1.00 75.32 C ATOM 8151 O THR A 1125 −26.206 31.935 0.302 1.00 72.16 O ATOM 8152 N ALA A 1126 −26.876 30.513 1.881 1.00 70.30 N ATOM 8153 CA ALA A 1126 −26.382 29.338 1.209 1.00 68.32 C ATOM 8154 CB ALA A 1126 −26.595 28.125 2.094 1.00 66.77 C ATOM 8155 C ALA A 1126 −27.139 29.158 −0.083 1.00 71.75 C ATOM 8156 O ALA A 1126 −26.564 28.976 −1.149 1.00 73.69 O ATOM 8157 N ASP A 1127 −28.455 29.224 0.025 1.00 78.64 N ATOM 8158 CA ASP A 1127 −29.320 29.073 −1.126 1.00 81.86 C ATOM 8159 CB ASP A 1127 −30.761 28.852 −0.685 1.00 83.87 C ATOM 8160 CG ASP A 1127 −30.931 27.556 0.117 1.00 87.63 C ATOM 8161 OD1 ASP A 1127 −30.786 26.457 −0.465 1.00 93.08 O ATOM 8162 OD2 ASP A 1127 −31.195 27.628 1.338 1.00 87.22 O ATOM 8163 C ASP A 1127 −29.182 30.232 −2.116 1.00 83.31 C ATOM 8164 O ASP A 1127 −29.364 30.019 −3.313 1.00 94.13 O ATOM 8165 N ASP A 1128 −28.830 31.426 −1.642 1.00 80.31 N ATOM 8166 CA ASP A 1128 −28.407 32.501 −2.547 1.00 88.29 C ATOM 8167 CB ASP A 1128 −27.889 33.733 −1.784 1.00 100.30 C ATOM 8168 CG ASP A 1128 −29.004 34.585 −1.170 1.00 109.02 C ATOM 8169 OD1 ASP A 1128 −30.185 34.436 −1.566 1.00 113.11 O ATOM 8170 OD2 ASP A 1128 −28.672 35.424 −0.285 1.00 113.50 O ATOM 8171 C ASP A 1128 −27.301 32.071 −3.508 1.00 82.61 C ATOM 8172 O ASP A 1128 −27.385 32.292 −4.714 1.00 85.57 O ATOM 8173 N LEU A 1129 −26.255 31.477 −2.968 1.00 77.55 N ATOM 8174 CA LEU A 1129 −25.132 31.089 −3.794 1.00 71.72 C ATOM 8175 CB LEU A 1129 −23.836 30.976 −2.999 1.00 71.49 C ATOM 8176 CG LEU A 1129 −23.125 32.318 −2.889 1.00 71.88 C ATOM 8177 CD1 LEU A 1129 −22.623 32.749 −4.239 1.00 71.37 C ATOM 8178 CD2 LEU A 1129 −24.034 33.402 −2.330 1.00 76.85 C ATOM 8179 C LEU A 1129 −25.416 29.824 −4.508 1.00 67.40 C ATOM 8180 O LEU A 1129 −24.960 29.675 −5.620 1.00 64.90 O ATOM 8181 N ILE A 1130 −26.171 28.912 −3.919 1.00 64.56 N ATOM 8182 CA ILE A 1130 −26.503 27.747 −4.687 1.00 71.94 C ATOM 8183 CB ILE A 1130 −27.432 26.750 −3.969 1.00 73.62 C ATOM 8184 CG1 ILE A 1130 −26.649 25.944 −2.907 1.00 74.67 C ATOM 8185 CD1 ILE A 1130 −27.416 24.820 −2.221 1.00 71.65 C ATOM 8186 CG2 ILE A 1130 −28.044 25.787 −4.993 1.00 74.03 C ATOM 8187 C ILE A 1130 −27.111 28.168 −6.030 1.00 75.95 C ATOM 8188 O ILE A 1130 −26.720 27.663 −7.059 1.00 75.96 O ATOM 8189 N LYS A 1131 −28.054 29.089 −6.055 1.00 84.17 N ATOM 8190 CA LYS A 1131 −28.716 29.328 −7.348 1.00 93.98 C ATOM 8191 CB LYS A 1131 −30.187 29.831 −7.182 1.00 101.96 C ATOM 8192 CG LYS A 1131 −30.402 31.277 −6.761 1.00 105.97 C ATOM 8193 CD LYS A 1131 −31.009 32.131 −7.880 1.00 106.51 C ATOM 8194 CE LYS A 1131 −31.179 33.583 −7.451 1.00 102.89 C ATOM 8195 NZ LYS A 1131 −29.910 34.156 −6.906 1.00 100.97 N ATOM 8196 C LYS A 1131 −27.834 30.097 −8.385 1.00 83.61 C ATOM 8197 O LYS A 1131 −28.072 29.986 −9.589 1.00 86.97 O ATOM 8198 N VAL A 1132 −26.825 30.824 −7.915 1.00 69.53 N ATOM 8199 CA VAL A 1132 −25.798 31.397 −8.779 1.00 68.14 C ATOM 8200 CB VAL A 1132 −24.820 32.263 −7.947 1.00 68.47 C ATOM 8201 CG1 VAL A 1132 −23.518 32.583 −8.693 1.00 67.52 C ATOM 8202 CG2 VAL A 1132 −25.506 33.527 −7.482 1.00 68.76 C ATOM 8203 C VAL A 1132 −24.939 30.330 −9.463 1.00 68.05 C ATOM 8204 O VAL A 1132 −24.682 30.372 −10.663 1.00 69.56 O ATOM 8205 N VAL A 1133 −24.443 29.413 −8.656 1.00 67.91 N ATOM 8206 CA VAL A 1133 −23.476 28.432 −9.091 1.00 66.60 C ATOM 8207 CB VAL A 1133 −22.802 27.716 −7.878 1.00 62.19 C ATOM 8208 CG1 VAL A 1133 −21.839 26.639 −8.292 1.00 63.29 C ATOM 8209 CG2 VAL A 1133 −22.006 28.696 −7.069 1.00 59.65 C ATOM 8210 C VAL A 1133 −24.198 27.496 −10.067 1.00 69.54 C ATOM 8211 O VAL A 1133 −23.618 27.170 −11.107 1.00 76.94 O ATOM 8212 N GLU A 1134 −25.465 27.143 −9.796 1.00 71.04 N ATOM 8213 CA GLU A 1134 −26.271 26.368 −10.767 1.00 71.48 C ATOM 8214 CB GLU A 1134 −27.547 25.725 −10.182 1.00 72.38 C ATOM 8215 CG GLU A 1134 −27.359 24.243 −9.776 1.00 81.36 C ATOM 8216 CD GLU A 1134 −28.215 23.760 −8.556 1.00 90.44 C ATOM 8217 OE1 GLU A 1134 −29.389 24.186 −8.424 1.00 100.22 O ATOM 8218 OE2 GLU A 1134 −27.745 22.927 −7.712 1.00 83.38 O ATOM 8219 C GLU A 1134 −26.557 27.176 −12.023 1.00 69.29 C ATOM 8220 O GLU A 1134 −26.689 26.594 −13.049 1.00 65.64 O ATOM 8221 N GLU A 1135 −26.594 28.498 −11.967 1.00 72.94 N ATOM 8222 CA GLU A 1135 −26.612 29.302 −13.201 1.00 76.92 C ATOM 8223 CB GLU A 1135 −27.069 30.771 −12.979 1.00 86.14 C ATOM 8224 CG GLU A 1135 −28.611 30.911 −12.809 1.00 96.25 C ATOM 8225 CD GLU A 1135 −29.130 32.353 −12.600 1.00 100.02 C ATOM 8226 OE1 GLU A 1135 −29.738 32.607 −11.527 1.00 97.06 O ATOM 8227 OE2 GLU A 1135 −28.956 33.225 −13.497 1.00 98.62 O ATOM 8228 C GLU A 1135 −25.285 29.237 −13.943 1.00 75.65 C ATOM 8229 O GLU A 1135 −25.250 29.373 −15.167 1.00 81.68 O ATOM 8230 N LEU A 1136 −24.195 29.020 −13.234 1.00 71.27 N ATOM 8231 CA LEU A 1136 −22.904 28.923 −13.897 1.00 67.34 C ATOM 8232 CB LEU A 1136 −21.773 29.302 −12.933 1.00 66.87 C ATOM 8233 CG LEU A 1136 −21.604 30.818 −12.728 1.00 63.63 C ATOM 8234 CD1 LEU A 1136 −20.439 31.164 −11.818 1.00 64.10 C ATOM 8235 CD2 LEU A 1136 −21.376 31.497 −14.058 1.00 64.04 C ATOM 8236 C LEU A 1136 −22.666 27.564 −14.533 1.00 65.34 C ATOM 8237 O LEU A 1136 −21.949 27.478 −15.539 1.00 64.68 O ATOM 8238 N THR A 1137 −23.272 26.514 −13.974 1.00 61.82 N ATOM 8239 CA THR A 1137 −23.104 25.175 −14.546 1.00 64.42 C ATOM 8240 CB THR A 1137 −23.729 23.994 −13.732 1.00 62.87 C ATOM 8241 OG1 THR A 1137 −25.034 24.319 −13.282 1.00 62.30 O ATOM 8242 CG2 THR A 1137 −22.883 23.612 −12.547 1.00 62.21 C ATOM 8243 C THR A 1137 −23.704 25.087 −15.909 1.00 67.85 C ATOM 8244 O THR A 1137 −23.273 24.273 −16.708 1.00 75.70 O ATOM 8245 N ARG A 1138 −24.707 25.915 −16.166 1.00 75.58 N ATOM 8246 CA ARG A 1138 −25.502 25.833 −17.383 1.00 76.40 C ATOM 8247 CB ARG A 1138 −26.987 26.184 −17.081 1.00 78.97 C ATOM 8248 CG ARG A 1138 −27.760 24.941 −16.607 1.00 82.77 C ATOM 8249 CD ARG A 1138 −29.058 25.221 −15.840 1.00 80.87 C ATOM 8250 NE ARG A 1138 −29.027 24.507 −14.556 1.00 78.71 N ATOM 8251 CZ ARG A 1138 −29.754 24.793 −13.469 1.00 77.26 C ATOM 8252 NH1 ARG A 1138 −30.681 25.769 −13.488 1.00 73.17 N ATOM 8253 NH2 ARG A 1138 −29.565 24.056 −12.351 1.00 76.98 N ATOM 8254 C ARG A 1138 −24.933 26.638 −18.548 1.00 73.29 C ATOM 8255 O ARG A 1138 −25.674 26.923 −19.493 1.00 81.67 O ATOM 8256 N ILE A 1139 −23.640 26.994 −18.503 1.00 66.38 N ATOM 8257 CA ILE A 1139 −22.959 27.474 −19.708 1.00 63.29 C ATOM 8258 CB ILE A 1139 −21.979 28.626 −19.445 1.00 61.84 C ATOM 8259 CG1 ILE A 1139 −20.709 28.167 −18.743 1.00 63.94 C ATOM 8260 CD1 ILE A 1139 −19.840 29.331 −18.298 1.00 65.73 C ATOM 8261 CG2 ILE A 1139 −22.644 29.723 −18.658 1.00 62.93 C ATOM 8262 C ILE A 1139 −22.211 26.394 −20.473 1.00 64.13 C ATOM 8263 O ILE A 1139 −21.513 26.731 −21.436 1.00 68.22 O ATOM 8264 N HIS A 1140 −22.342 25.121 −20.080 1.00 61.71 N ATOM 8265 CA HIS A 1140 −21.523 24.060 −20.674 1.00 61.54 C ATOM 8266 CB HIS A 1140 −20.081 24.172 −20.139 1.00 60.91 C ATOM 8267 CG HIS A 1140 −19.916 23.647 −18.745 1.00 59.88 C ATOM 8268 ND1 HIS A 1140 −19.527 22.355 −18.480 1.00 60.58 N ATOM 8269 CE1 HIS A 1140 −19.485 22.164 −17.179 1.00 58.80 C ATOM 8270 NE2 HIS A 1140 −19.848 23.279 −16.589 1.00 58.33 N ATOM 8271 CD2 HIS A 1140 −20.126 24.223 −17.545 1.00 60.23 C ATOM 8272 C HIS A 1140 −22.085 22.622 −20.482 1.00 60.81 C ATOM 8273 O HIS A 1140 −22.778 22.312 −19.517 1.00 60.07 O TER 8274 HIS A 1140 ATOM 8275 N ILE C 47 45.485 29.607 −47.725 1.00 76.28 N ATOM 8276 CA ILE C 47 45.722 30.399 −46.437 1.00 85.04 C ATOM 8277 CB ILE C 47 44.385 30.714 −45.680 1.00 89.53 C ATOM 8278 CG1 ILE C 47 44.609 31.736 −44.539 1.00 86.82 C ATOM 8279 CD1 ILE C 47 43.359 32.096 −43.759 1.00 83.92 C ATOM 8280 CG2 ILE C 47 43.719 29.424 −45.158 1.00 93.27 C ATOM 8281 C ILE C 47 46.724 29.765 −45.435 1.00 86.59 C ATOM 8282 O ILE C 47 46.509 28.640 −44.979 1.00 91.11 O ATOM 8283 N ASN C 48 47.787 30.489 −45.059 1.00 87.47 N ATOM 8284 CA ASN C 48 48.737 29.992 −44.030 1.00 89.53 C ATOM 8285 CB ASN C 48 49.847 29.135 −44.632 1.00 90.05 C ATOM 8286 CG ASN C 48 50.462 29.757 −45.877 1.00 90.10 C ATOM 8287 OD1 ASN C 48 50.288 29.217 −46.986 1.00 94.29 O ATOM 8288 ND2 ASN C 48 51.197 30.872 −45.715 1.00 82.18 N ATOM 8289 C ASN C 48 49.312 31.129 −43.210 1.00 93.00 C ATOM 8290 O ASN C 48 50.537 31.339 −43.115 1.00 95.29 O ATOM 8291 N PHE C 49 48.384 31.877 −42.635 1.00 91.27 N ATOM 8292 CA PHE C 49 48.682 32.955 −41.712 1.00 84.82 C ATOM 8293 CB PHE C 49 48.061 34.277 −42.219 1.00 80.58 C ATOM 8294 CG PHE C 49 47.895 35.335 −41.159 1.00 70.15 C ATOM 8295 CD1 PHE C 49 48.963 36.149 −40.798 1.00 64.30 C ATOM 8296 CE1 PHE C 49 48.804 37.131 −39.837 1.00 63.87 C ATOM 8297 CZ PHE C 49 47.569 37.318 −39.223 1.00 63.49 C ATOM 8298 CE2 PHE C 49 46.491 36.509 −39.573 1.00 65.05 C ATOM 8299 CD2 PHE C 49 46.655 35.528 −40.541 1.00 67.24 C ATOM 8300 C PHE C 49 48.099 32.498 −40.383 1.00 78.68 C ATOM 8301 O PHE C 49 47.046 31.844 −40.328 1.00 79.20 O ATOM 8302 N ASP C 50 48.787 32.851 −39.315 1.00 69.33 N ATOM 8303 CA ASP C 50 48.457 32.323 −38.024 1.00 62.13 C ATOM 8304 CB ASP C 50 49.642 32.542 −37.129 1.00 61.92 C ATOM 8305 CG ASP C 50 49.567 31.767 −35.892 1.00 60.39 C ATOM 8306 OD1 ASP C 50 48.524 31.801 −35.195 1.00 60.41 O ATOM 8307 OD2 ASP C 50 50.595 31.143 −35.608 1.00 63.25 O ATOM 8308 C ASP C 50 47.218 33.021 −37.508 1.00 62.25 C ATOM 8309 O ASP C 50 47.272 34.133 −36.956 1.00 62.44 O ATOM 8310 N THR C 51 46.078 32.363 −37.659 1.00 64.06 N ATOM 8311 CA THR C 51 44.821 33.033 −37.330 1.00 64.01 C ATOM 8312 CB THR C 51 43.576 32.289 −37.875 1.00 61.77 C ATOM 8313 OG1 THR C 51 43.554 30.976 −37.353 1.00 68.93 O ATOM 8314 CG2 THR C 51 43.628 32.189 −39.367 1.00 62.50 C ATOM 8315 C THR C 51 44.619 33.352 −35.850 1.00 62.45 C ATOM 8316 O THR C 51 43.541 33.807 −35.515 1.00 67.50 O ATOM 8317 N SER C 52 45.603 33.115 −34.971 1.00 62.62 N ATOM 8318 CA SER C 52 45.547 33.653 −33.581 1.00 65.23 C ATOM 8319 CB SER C 52 45.789 32.555 −32.537 1.00 62.29 C ATOM 8320 OG SER C 52 47.069 32.004 −32.691 1.00 61.74 O ATOM 8321 C SER C 52 46.434 34.907 −33.292 1.00 64.00 C ATOM 8322 O SER C 52 46.164 35.627 −32.308 1.00 61.44 O ATOM 8323 N LEU C 53 47.431 35.204 −34.150 1.00 63.48 N ATOM 8324 CA LEU C 53 48.299 36.407 −33.971 1.00 61.10 C ATOM 8325 CB LEU C 53 49.417 36.532 −35.083 1.00 51.50 C ATOM 8326 C LEU C 53 47.353 37.654 −33.782 1.00 63.15 C ATOM 8327 O LEU C 53 47.570 38.470 −32.883 1.00 65.58 O ATOM 8328 N PRO C 54 46.254 37.749 −34.569 1.00 63.96 N ATOM 8329 CA PRO C 54 45.376 38.929 −34.470 1.00 65.04 C ATOM 8330 CB PRO C 54 44.399 38.766 −35.653 1.00 63.78 C ATOM 8331 CG PRO C 54 45.130 37.905 −36.593 1.00 65.70 C ATOM 8332 CD PRO C 54 45.934 36.951 −35.767 1.00 65.33 C ATOM 8333 C PRO C 54 44.588 39.069 −33.193 1.00 61.09 C ATOM 8334 O PRO C 54 44.498 40.145 −32.629 1.00 61.73 O ATOM 8335 N THR C 55 43.994 38.002 −32.748 1.00 64.81 N ATOM 8336 CA THR C 55 43.256 38.105 −31.525 1.00 74.75 C ATOM 8337 CB THR C 55 42.454 36.821 −31.208 1.00 81.47 C ATOM 8338 OG1 THR C 55 41.473 37.161 −30.213 1.00 84.30 O ATOM 8339 CG2 THR C 55 43.375 35.604 −30.729 1.00 80.87 C ATOM 8340 C THR C 55 44.130 38.500 −30.309 1.00 71.82 C ATOM 8341 O THR C 55 43.584 38.971 −29.308 1.00 65.73 O ATOM 8342 N SER C 56 45.455 38.297 −30.367 1.00 69.23 N ATOM 8343 CA SER C 56 46.296 38.656 −29.207 1.00 65.03 C ATOM 8344 CB SER C 56 47.484 37.672 −28.991 1.00 63.23 C ATOM 8345 OG SER C 56 48.343 37.649 −30.093 1.00 60.76 O ATOM 8346 C SER C 56 46.738 40.105 −29.173 1.00 57.76 C ATOM 8347 O SER C 56 47.267 40.528 −28.150 1.00 58.45 O ATOM 8348 N HIS C 57 46.499 40.855 −30.252 1.00 54.29 N ATOM 8349 CA HIS C 57 46.774 42.304 −30.329 1.00 53.98 C ATOM 8350 CB HIS C 57 45.767 43.080 −29.500 1.00 51.92 C ATOM 8351 CG HIS C 57 44.368 42.906 −29.960 1.00 52.52 C ATOM 8352 ND1 HIS C 57 43.731 43.821 −30.762 1.00 57.14 N ATOM 8353 CE1 HIS C 57 42.506 43.406 −31.026 1.00 54.05 C ATOM 8354 NE2 HIS C 57 42.321 42.261 −30.410 1.00 54.38 N ATOM 8355 CD2 HIS C 57 43.477 41.922 −29.746 1.00 53.14 C ATOM 8356 C HIS C 57 48.199 42.684 −29.917 1.00 56.28 C ATOM 8357 O HIS C 57 48.423 43.488 −28.995 1.00 54.98 O ATOM 8358 N THR C 58 49.159 42.078 −30.608 1.00 61.04 N ATOM 8359 CA THR C 58 50.586 42.232 −30.277 1.00 62.63 C ATOM 8360 CB THR C 58 51.497 41.364 −31.168 1.00 62.62 C ATOM 8361 OG1 THR C 58 51.373 41.786 −32.540 1.00 65.30 O ATOM 8362 CG2 THR C 58 51.156 39.881 −31.023 1.00 61.74 C ATOM 8363 C THR C 58 51.035 43.667 −30.447 1.00 59.39 C ATOM 8364 O THR C 58 51.781 44.186 −29.647 1.00 65.69 O ATOM 8365 N TYR C 59 50.572 44.305 −31.494 1.00 54.88 N ATOM 8366 CA TYR C 59 50.864 45.708 −31.707 1.00 57.26 C ATOM 8367 CB TYR C 59 50.000 46.244 −32.842 1.00 60.65 C ATOM 8368 CG TYR C 59 48.521 46.225 −32.564 1.00 56.91 C ATOM 8369 CD1 TYR C 59 47.924 47.271 −31.897 1.00 56.91 C ATOM 8370 CE1 TYR C 59 46.559 47.284 −31.656 1.00 58.72 C ATOM 8371 CZ TYR C 59 45.780 46.240 −32.088 1.00 55.31 C ATOM 8372 OH TYR C 59 44.442 46.309 −31.849 1.00 52.37 O ATOM 8373 CE2 TYR C 59 46.355 45.166 −32.741 1.00 56.15 C ATOM 8374 CD2 TYR C 59 47.724 45.167 −32.978 1.00 55.79 C ATOM 8375 C TYR C 59 50.675 46.630 −30.512 1.00 53.64 C ATOM 8376 O TYR C 59 51.116 47.780 −30.550 1.00 50.49 O ATOM 8377 N LEU C 60 49.957 46.171 −29.499 1.00 52.53 N ATOM 8378 CA LEU C 60 49.948 46.880 −28.238 1.00 53.92 C ATOM 8379 CB LEU C 60 48.718 46.502 −27.430 1.00 53.51 C ATOM 8380 CG LEU C 60 47.368 46.886 −28.020 1.00 54.29 C ATOM 8381 CD1 LEU C 60 46.295 46.329 −27.104 1.00 56.38 C ATOM 8382 CD2 LEU C 60 47.194 48.390 −28.125 1.00 54.71 C ATOM 8383 C LEU C 60 51.204 46.696 −27.392 1.00 53.83 C ATOM 8384 O LEU C 60 51.362 47.414 −26.425 1.00 53.57 O ATOM 8385 N GLY C 61 52.106 45.800 −27.776 1.00 59.28 N ATOM 8386 CA GLY C 61 53.140 45.255 −26.875 1.00 72.32 C ATOM 8387 C GLY C 61 52.694 43.938 −26.217 1.00 83.65 C ATOM 8388 O GLY C 61 51.549 43.826 −25.716 1.00 82.22 O ATOM 8389 N ALA C 62 53.582 42.936 −26.207 1.00 90.91 N ATOM 8390 CA ALA C 62 53.187 41.569 −25.791 1.00 95.99 C ATOM 8391 CB ALA C 62 53.595 40.543 −26.869 1.00 90.56 C ATOM 8392 C ALA C 62 53.656 41.122 −24.368 1.00 99.55 C ATOM 8393 O ALA C 62 53.689 39.909 −24.103 1.00 99.54 O ATOM 8394 N ASP C 63 54.016 42.067 −23.471 1.00 98.59 N ATOM 8395 CA ASP C 63 54.252 41.743 −22.024 1.00 96.20 C ATOM 8396 CB ASP C 63 55.726 41.919 −21.579 1.00 94.76 C ATOM 8397 C ASP C 63 53.294 42.563 −21.155 1.00 87.49 C ATOM 8398 O ASP C 63 53.663 43.572 −20.567 1.00 83.25 O ATOM 8399 N MET C 64 52.047 42.106 −21.118 1.00 82.32 N ATOM 8400 CA MET C 64 50.970 42.743 −20.373 1.00 83.71 C ATOM 8401 CB MET C 64 49.689 42.766 −21.224 1.00 87.98 C ATOM 8402 CG MET C 64 49.752 43.511 −22.549 1.00 90.37 C ATOM 8403 SD MET C 64 48.260 44.495 −22.838 1.00 93.35 S ATOM 8404 CE MET C 64 48.360 44.706 −24.608 1.00 97.50 C ATOM 8405 C MET C 64 50.671 41.867 −19.169 1.00 79.81 C ATOM 8406 O MET C 64 50.605 40.656 −19.367 1.00 71.84 O ATOM 8407 N GLU C 65 50.465 42.446 −17.964 1.00 77.03 N ATOM 8408 CA GLU C 65 49.963 41.665 −16.785 1.00 75.21 C ATOM 8409 CB GLU C 65 50.120 42.426 −15.419 1.00 69.86 C ATOM 8410 C GLU C 65 48.500 41.190 −17.123 1.00 71.98 C ATOM 8411 O GLU C 65 47.714 41.948 −17.694 1.00 70.03 O ATOM 8412 N GLU C 66 48.205 39.939 −16.826 1.00 69.42 N ATOM 8413 CA GLU C 66 46.934 39.355 −17.153 1.00 70.40 C ATOM 8414 CB GLU C 66 47.152 38.086 −17.949 1.00 75.19 C ATOM 8415 CG GLU C 66 47.698 38.302 −19.339 1.00 84.30 C ATOM 8416 CD GLU C 66 48.019 37.004 −20.045 1.00 96.74 C ATOM 8417 OE1 GLU C 66 48.905 37.012 −20.922 1.00 103.78 O ATOM 8418 OE2 GLU C 66 47.393 35.972 −19.726 1.00 92.29 O ATOM 8419 C GLU C 66 46.167 38.988 −15.933 1.00 71.53 C ATOM 8420 O GLU C 66 46.729 38.591 −14.942 1.00 76.21 O ATOM 8421 N PHE C 67 44.860 39.125 −16.008 1.00 77.64 N ATOM 8422 CA PHE C 67 44.014 38.796 −14.894 1.00 80.54 C ATOM 8423 CB PHE C 67 43.252 40.033 −14.485 1.00 80.45 C ATOM 8424 CG PHE C 67 44.118 41.245 −14.385 1.00 81.65 C ATOM 8425 CD1 PHE C 67 44.358 42.023 −15.479 1.00 84.06 C ATOM 8426 CE1 PHE C 67 45.164 43.130 −15.399 1.00 82.68 C ATOM 8427 CZ PHE C 67 45.750 43.466 −14.215 1.00 77.70 C ATOM 8428 CE2 PHE C 67 45.528 42.688 −13.115 1.00 77.83 C ATOM 8429 CD2 PHE C 67 44.717 41.581 −13.206 1.00 79.62 C ATOM 8430 C PHE C 67 43.112 37.673 −15.346 1.00 84.78 C ATOM 8431 O PHE C 67 42.556 37.742 −16.425 1.00 90.09 O ATOM 8432 N HIS C 68 42.968 36.631 −14.536 1.00 83.49 N ATOM 8433 CA HIS C 68 42.156 35.512 −14.959 1.00 85.74 C ATOM 8434 CB HIS C 68 42.376 34.317 −14.057 1.00 83.79 C ATOM 8435 C HIS C 68 40.750 35.956 −14.836 1.00 92.68 C ATOM 8436 O HIS C 68 40.228 36.133 −13.749 1.00 84.18 O ATOM 8437 N GLY C 69 40.136 36.104 −15.995 1.00 106.99 N ATOM 8438 CA GLY C 69 38.789 36.596 −16.106 1.00 113.75 C ATOM 8439 C GLY C 69 37.718 35.764 −15.470 1.00 116.41 C ATOM 8440 O GLY C 69 37.740 34.551 −15.490 1.00 114.70 O ATOM 8441 N ARG C 70 36.757 36.450 −14.894 1.00 120.06 N ATOM 8442 CA ARG C 70 35.639 35.752 −14.272 1.00 115.01 C ATOM 8443 CB ARG C 70 36.267 34.767 −13.291 1.00 125.64 C ATOM 8444 CG ARG C 70 37.105 35.432 −12.187 1.00 129.65 C ATOM 8445 CD ARG C 70 36.424 35.363 −10.818 1.00 132.10 C ATOM 8446 NE ARG C 70 36.104 33.972 −10.416 1.00 123.68 N ATOM 8447 CZ ARG C 70 34.906 33.509 −10.026 1.00 109.22 C ATOM 8448 NH1 ARG C 70 33.837 34.312 −9.926 1.00 110.25 N ATOM 8449 NH2 ARG C 70 34.783 32.222 −9.700 1.00 94.55 N ATOM 8450 C ARG C 70 34.527 36.533 −13.528 1.00 103.06 C ATOM 8451 O ARG C 70 33.580 35.903 −13.071 1.00 93.46 O ATOM 8452 N THR C 71 34.608 37.860 −13.403 1.00 93.59 N ATOM 8453 CA THR C 71 33.662 38.610 −12.544 1.00 87.92 C ATOM 8454 CB THR C 71 34.142 40.062 −12.207 1.00 84.04 C ATOM 8455 OG1 THR C 71 33.748 40.976 −13.244 1.00 85.01 O ATOM 8456 CG2 THR C 71 35.671 40.143 −12.016 1.00 83.33 C ATOM 8457 C THR C 71 32.274 38.628 −13.252 1.00 81.29 C ATOM 8458 O THR C 71 32.200 39.038 −14.429 1.00 81.94 O ATOM 8459 N LEU C 72 31.213 38.164 −12.552 1.00 67.36 N ATOM 8460 CA LEU C 72 29.837 38.057 −13.098 1.00 59.85 C ATOM 8461 CB LEU C 72 29.504 36.614 −13.543 1.00 57.22 C ATOM 8462 CG LEU C 72 29.928 36.202 −14.964 1.00 57.76 C ATOM 8463 CD1 LEU C 72 29.116 34.979 −15.346 1.00 57.15 C ATOM 8464 CD2 LEU C 72 29.799 37.325 −16.032 1.00 56.03 C ATOM 8465 C LEU C 72 28.787 38.508 −12.109 1.00 55.74 C ATOM 8466 O LEU C 72 28.478 37.799 −11.170 1.00 62.92 O ATOM 8467 N HIS C 73 28.219 39.679 −12.328 1.00 51.20 N ATOM 8468 CA HIS C 73 27.194 40.205 −11.446 1.00 50.44 C ATOM 8469 CB HIS C 73 26.951 41.647 −11.761 1.00 50.96 C ATOM 8470 CG HIS C 73 28.134 42.503 −11.510 1.00 49.99 C ATOM 8471 ND1 HIS C 73 28.725 42.587 −10.274 1.00 53.06 N ATOM 8472 CE1 HIS C 73 29.737 43.428 −10.329 1.00 51.89 C ATOM 8473 NE2 HIS C 73 29.819 43.892 −11.558 1.00 49.80 N ATOM 8474 CD2 HIS C 73 28.824 43.330 −12.316 1.00 50.45 C ATOM 8475 C HIS C 73 25.874 39.483 −11.528 1.00 51.77 C ATOM 8476 O HIS C 73 25.519 38.969 −12.554 1.00 47.53 O ATOM 8477 N ASP C 74 25.143 39.482 −10.419 1.00 61.00 N ATOM 8478 CA ASP C 74 23.942 38.654 −10.263 1.00 66.70 C ATOM 8479 CB ASP C 74 23.488 38.597 −8.755 1.00 75.06 C ATOM 8480 CG ASP C 74 24.435 37.711 −7.798 1.00 80.54 C ATOM 8481 OD2 ASP C 74 25.435 38.191 −7.167 1.00 78.16 O ATOM 8482 OD1 ASP C 74 24.101 36.522 −7.602 1.00 84.83 O ATOM 8483 C ASP C 74 22.860 39.242 −11.204 1.00 63.26 C ATOM 8484 O ASP C 74 22.882 40.450 −11.522 1.00 55.42 O ATOM 8485 N ASP C 75 21.960 38.391 −11.692 1.00 65.44 N ATOM 8486 CA ASP C 75 20.861 38.864 −12.553 1.00 71.27 C ATOM 8487 CB ASP C 75 19.972 37.737 −13.052 1.00 73.65 C ATOM 8488 CG ASP C 75 20.630 36.887 −14.065 1.00 74.19 C ATOM 8489 OD1 ASP C 75 21.489 37.407 −14.808 1.00 73.53 O ATOM 8490 OD2 ASP C 75 20.266 35.691 −14.108 1.00 72.06 O ATOM 8491 C ASP C 75 19.926 39.761 −11.800 1.00 72.91 C ATOM 8492 O ASP C 75 19.491 39.430 −10.710 1.00 76.11 O ATOM 8493 N ASP C 76 19.587 40.871 −12.429 1.00 75.17 N ATOM 8494 CA ASP C 76 18.680 41.882 −11.891 1.00 73.34 C ATOM 8495 CB ASP C 76 17.309 41.289 −11.513 1.00 73.83 C ATOM 8496 CG ASP C 76 16.674 40.487 −12.676 1.00 81.22 C ATOM 8497 OD1 ASP C 76 16.222 41.088 −13.676 1.00 85.58 O ATOM 8498 OD2 ASP C 76 16.636 39.241 −12.609 1.00 87.30 O ATOM 8499 C ASP C 76 19.320 42.757 −10.800 1.00 68.70 C ATOM 8500 O ASP C 76 18.701 43.722 −10.364 1.00 68.89 O ATOM 8501 N SER C 77 20.590 42.510 −10.463 1.00 68.16 N ATOM 8502 CA SER C 77 21.306 43.326 −9.460 1.00 70.90 C ATOM 8503 CB SER C 77 22.616 42.653 −9.048 1.00 67.32 C ATOM 8504 OG SER C 77 23.637 42.911 −9.995 1.00 67.74 O ATOM 8505 C SER C 77 21.589 44.747 −9.988 1.00 73.21 C ATOM 8506 O SER C 77 21.450 44.989 −11.192 1.00 83.18 O ATOM 8507 N CYS C 78 21.953 45.676 −9.096 1.00 72.30 N ATOM 8508 CA CYS C 78 22.369 47.029 −9.500 1.00 71.12 C ATOM 8509 CB CYS C 78 21.533 48.100 −8.819 1.00 73.34 C ATOM 8510 SG CYS C 78 19.849 48.092 −9.494 1.00 91.20 S ATOM 8511 C CYS C 78 23.840 47.231 −9.240 1.00 67.19 C ATOM 8512 O CYS C 78 24.378 46.731 −8.272 1.00 66.47 O ATOM 8513 N GLN C 79 24.508 47.934 −10.137 1.00 67.96 N ATOM 8514 CA GLN C 79 25.949 48.134 −10.022 1.00 67.85 C ATOM 8515 CB GLN C 79 26.704 47.194 −10.973 1.00 69.96 C ATOM 8516 CG GLN C 79 26.515 45.706 −10.714 1.00 69.73 C ATOM 8517 CD GLN C 79 26.793 45.291 −9.284 1.00 65.30 C ATOM 8518 OE1 GLN C 79 27.566 45.924 −8.567 1.00 63.82 O ATOM 8519 NE2 GLN C 79 26.145 44.225 −8.863 1.00 63.47 N ATOM 8520 C GLN C 79 26.352 49.554 −10.341 1.00 65.61 C ATOM 8521 O GLN C 79 25.688 50.221 −11.129 1.00 59.34 O ATOM 8522 N VAL C 80 27.444 49.997 −9.715 1.00 66.52 N ATOM 8523 CA VAL C 80 28.015 51.287 −10.018 1.00 70.57 C ATOM 8524 CB VAL C 80 28.098 52.247 −8.812 1.00 73.00 C ATOM 8525 CG1 VAL C 80 28.109 53.666 −9.345 1.00 72.73 C ATOM 8526 CG2 VAL C 80 26.930 52.058 −7.846 1.00 74.19 C ATOM 8527 C VAL C 80 29.394 51.029 −10.604 1.00 72.07 C ATOM 8528 O VAL C 80 30.310 50.603 −9.912 1.00 72.99 O ATOM 8529 N ILE C 81 29.494 51.311 −11.899 1.00 70.25 N ATOM 8530 CA ILE C 81 30.612 51.006 −12.728 1.00 65.68 C ATOM 8531 CB ILE C 81 30.168 50.071 −13.859 1.00 71.76 C ATOM 8532 CG1 ILE C 81 29.131 49.074 −13.386 1.00 74.87 C ATOM 8533 CD1 ILE C 81 28.745 48.078 −14.460 1.00 77.00 C ATOM 8534 CG2 ILE C 81 31.345 49.295 −14.406 1.00 77.31 C ATOM 8535 C ILE C 81 31.000 52.298 −13.415 1.00 61.78 C ATOM 8536 O ILE C 81 30.143 53.010 −13.886 1.00 64.21 O ATOM 8537 N PRO C 82 32.287 52.581 −13.555 1.00 58.71 N ATOM 8538 CA PRO C 82 32.711 53.746 −14.342 1.00 56.56 C ATOM 8539 CB PRO C 82 34.202 53.835 −14.033 1.00 56.25 C ATOM 8540 CG PRO C 82 34.586 52.442 −13.740 1.00 57.24 C ATOM 8541 CD PRO C 82 33.436 51.843 −13.013 1.00 59.02 C ATOM 8542 C PRO C 82 32.495 53.636 −15.865 1.00 54.63 C ATOM 8543 O PRO C 82 32.114 52.598 −16.349 1.00 51.70 O ATOM 8544 N VAL C 83 32.739 54.714 −16.604 1.00 55.40 N ATOM 8545 CA VAL C 83 32.429 54.747 −18.027 1.00 58.94 C ATOM 8546 CB VAL C 83 31.163 55.569 −18.318 1.00 56.73 C ATOM 8547 CG1 VAL C 83 30.952 55.740 −19.811 1.00 57.75 C ATOM 8548 CG2 VAL C 83 29.936 54.925 −17.685 1.00 54.24 C ATOM 8549 C VAL C 83 33.613 55.317 −18.773 1.00 67.75 C ATOM 8550 O VAL C 83 34.135 56.359 −18.380 1.00 79.00 O ATOM 8551 N LEU C 84 34.044 54.600 −19.815 1.00 73.10 N ATOM 8552 CA LEU C 84 35.196 54.963 −20.585 1.00 79.84 C ATOM 8553 CB LEU C 84 35.449 53.975 −21.700 1.00 87.72 C ATOM 8554 CG LEU C 84 36.313 52.767 −21.452 1.00 93.86 C ATOM 8555 CD1 LEU C 84 36.458 52.068 −22.804 1.00 89.42 C ATOM 8556 CD2 LEU C 84 37.662 53.172 −20.828 1.00 97.29 C ATOM 8557 C LEU C 84 34.718 56.135 −21.272 1.00 88.06 C ATOM 8558 O LEU C 84 33.778 56.010 −22.035 1.00 96.02 O ATOM 8559 N PRO C 85 35.335 57.292 −21.042 1.00 104.09 N ATOM 8560 CA PRO C 85 34.862 58.401 −21.890 1.00 102.74 C ATOM 8561 CB PRO C 85 35.511 59.647 −21.257 1.00 108.87 C ATOM 8562 CG PRO C 85 36.300 59.162 −20.056 1.00 108.76 C ATOM 8563 CD PRO C 85 36.489 57.674 −20.205 1.00 105.90 C ATOM 8564 C PRO C 85 35.367 58.162 −23.299 1.00 95.64 C ATOM 8565 O PRO C 85 36.129 57.216 −23.552 1.00 93.36 O ATOM 8566 N GLN C 86 34.954 58.979 −24.235 1.00 91.24 N ATOM 8567 CA GLN C 86 35.638 58.957 −25.522 1.00 92.85 C ATOM 8568 CB GLN C 86 37.160 59.260 −25.358 1.00 88.35 C ATOM 8569 CG GLN C 86 37.583 60.661 −25.805 1.00 86.57 C ATOM 8570 CD GLN C 86 39.034 60.923 −25.467 1.00 88.16 C ATOM 8571 OE1 GLN C 86 39.361 61.843 −24.726 1.00 94.96 O ATOM 8572 NE2 GLN C 86 39.909 60.093 −25.983 1.00 90.19 N ATOM 8573 C GLN C 86 35.464 57.697 −26.367 1.00 90.02 C ATOM 8574 O GLN C 86 35.932 57.705 −27.501 1.00 96.04 O ATOM 8575 N VAL C 87 34.806 56.678 −25.861 1.00 90.08 N ATOM 8576 CA VAL C 87 34.638 55.518 −26.690 1.00 86.02 C ATOM 8577 CB VAL C 87 35.185 54.271 −26.017 1.00 88.43 C ATOM 8578 CG1 VAL C 87 34.887 53.045 −26.852 1.00 90.62 C ATOM 8579 CG2 VAL C 87 36.681 54.414 −25.844 1.00 90.63 C ATOM 8580 C VAL C 87 33.190 55.325 −26.985 1.00 82.25 C ATOM 8581 O VAL C 87 32.379 55.271 −26.091 1.00 80.67 O ATOM 8582 N MET C 88 32.875 55.214 −28.259 1.00 88.70 N ATOM 8583 CA MET C 88 31.515 54.988 −28.657 1.00 95.72 C ATOM 8584 CB MET C 88 31.099 56.037 −29.671 1.00 101.74 C ATOM 8585 CG MET C 88 31.656 57.403 −29.388 1.00 104.84 C ATOM 8586 SD MET C 88 30.868 57.967 −27.894 1.00 117.92 S ATOM 8587 CE MET C 88 32.062 59.178 −27.352 1.00 119.27 C ATOM 8588 C MET C 88 31.489 53.686 −29.382 1.00 86.45 C ATOM 8589 O MET C 88 32.087 53.572 −30.433 1.00 91.37 O ATOM 8590 N MET C 89 30.799 52.704 −28.842 1.00 75.44 N ATOM 8591 CA MET C 89 30.678 51.452 −29.540 1.00 74.44 C ATOM 8592 CB MET C 89 32.002 50.720 −29.688 1.00 72.22 C ATOM 8593 CG MET C 89 32.276 49.644 −28.682 1.00 76.87 C ATOM 8594 SD MET C 89 33.584 48.591 −29.286 1.00 84.72 S ATOM 8595 CE MET C 89 32.712 47.529 −30.404 1.00 73.20 C ATOM 8596 C MET C 89 29.596 50.665 −28.880 1.00 71.22 C ATOM 8597 O MET C 89 29.195 50.989 −27.784 1.00 81.02 O ATOM 8598 N ILE C 90 29.113 49.648 −29.564 1.00 63.74 N ATOM 8599 CA ILE C 90 28.038 48.800 −29.072 1.00 56.68 C ATOM 8600 CB ILE C 90 26.852 48.654 −30.060 1.00 58.23 C ATOM 8601 CG1 ILE C 90 25.987 49.914 −30.066 1.00 62.66 C ATOM 8602 CD1 ILE C 90 26.376 50.891 −31.129 1.00 68.38 C ATOM 8603 CG2 ILE C 90 25.935 47.519 −29.661 1.00 59.23 C ATOM 8604 C ILE C 90 28.774 47.533 −28.874 1.00 48.81 C ATOM 8605 O ILE C 90 29.044 46.833 −29.790 1.00 45.68 O ATOM 8606 N LEU C 91 29.110 47.269 −27.637 1.00 51.23 N ATOM 8607 CA LEU C 91 29.928 46.127 −27.252 1.00 51.24 C ATOM 8608 CB LEU C 91 30.660 46.446 −25.935 1.00 51.79 C ATOM 8609 CG LEU C 91 32.021 45.914 −25.510 1.00 50.66 C ATOM 8610 CD1 LEU C 91 31.916 45.500 −24.062 1.00 51.23 C ATOM 8611 CD2 LEU C 91 32.489 44.753 −26.347 1.00 51.26 C ATOM 8612 C LEU C 91 29.009 44.946 −27.048 1.00 49.80 C ATOM 8613 O LEU C 91 27.984 45.016 −26.359 1.00 48.82 O ATOM 8614 N ILE C 92 29.410 43.829 −27.600 1.00 49.21 N ATOM 8615 CA ILE C 92 28.622 42.626 −27.490 1.00 48.51 C ATOM 8616 CB ILE C 92 28.598 41.921 −28.838 1.00 46.59 C ATOM 8617 CG1 ILE C 92 27.892 42.837 −29.811 1.00 44.78 C ATOM 8618 CD1 ILE C 92 27.815 42.270 −31.202 1.00 47.09 C ATOM 8619 CG2 ILE C 92 27.925 40.565 −28.732 1.00 47.09 C ATOM 8620 C ILE C 92 29.282 41.751 −26.439 1.00 43.88 C ATOM 8621 O ILE C 92 30.484 41.644 −26.430 1.00 44.15 O ATOM 8622 N PRO C 93 28.505 41.096 −25.578 1.00 41.35 N ATOM 8623 CA PRO C 93 29.087 40.035 −24.731 1.00 38.54 C ATOM 8624 CB PRO C 93 27.877 39.247 −24.325 1.00 38.15 C ATOM 8625 CG PRO C 93 26.797 40.280 −24.195 1.00 39.44 C ATOM 8626 CD PRO C 93 27.072 41.300 −25.289 1.00 41.12 C ATOM 8627 C PRO C 93 30.077 39.144 −25.472 1.00 35.93 C ATOM 8628 O PRO C 93 29.924 38.873 −26.650 1.00 36.24 O ATOM 8629 N GLY C 94 31.155 38.798 −24.814 1.00 34.84 N ATOM 8630 CA GLY C 94 32.193 38.015 −25.426 1.00 36.77 C ATOM 8631 C GLY C 94 33.194 38.753 −26.290 1.00 40.04 C ATOM 8632 O GLY C 94 34.293 38.226 −26.483 1.00 41.74 O ATOM 8633 N GLN C 95 32.863 39.960 −26.772 1.00 42.15 N ATOM 8634 CA GLN C 95 33.672 40.664 −27.761 1.00 44.29 C ATOM 8635 CB GLN C 95 32.892 41.829 −28.398 1.00 48.46 C ATOM 8636 CG GLN C 95 33.324 42.216 −29.828 1.00 52.78 C ATOM 8637 CD GLN C 95 32.607 43.441 −30.402 1.00 53.63 C ATOM 8638 OE1 GLN C 95 33.214 44.204 −31.118 1.00 66.86 O ATOM 8639 NE2 GLN C 95 31.344 43.629 −30.100 1.00 51.26 N ATOM 8640 C GLN C 95 34.906 41.179 −27.088 1.00 45.91 C ATOM 8641 O GLN C 95 34.823 41.688 −25.996 1.00 48.19 O ATOM 8642 N THR C 96 36.055 40.990 −27.718 1.00 49.44 N ATOM 8643 CA THR C 96 37.330 41.463 −27.216 1.00 51.99 C ATOM 8644 CB THR C 96 38.491 40.542 −27.708 1.00 57.45 C ATOM 8645 OG1 THR C 96 39.477 40.365 −26.714 1.00 55.73 O ATOM 8646 CG2 THR C 96 39.234 41.091 −28.951 1.00 68.53 C ATOM 8647 C THR C 96 37.437 42.930 −27.719 1.00 55.64 C ATOM 8648 O THR C 96 37.212 43.221 −28.924 1.00 58.63 O ATOM 8649 N LEU C 97 37.771 43.821 −26.768 1.00 57.23 N ATOM 8650 CA LEU C 97 37.855 45.283 −26.904 1.00 49.43 C ATOM 8651 CB LEU C 97 36.794 45.923 −26.043 1.00 47.66 C ATOM 8652 CG LEU C 97 36.829 47.451 −25.918 1.00 48.84 C ATOM 8653 CD1 LEU C 97 37.174 48.137 −27.226 1.00 46.65 C ATOM 8654 CD2 LEU C 97 35.472 47.931 −25.384 1.00 50.11 C ATOM 8655 C LEU C 97 39.227 45.785 −26.417 1.00 48.39 C ATOM 8656 O LEU C 97 39.465 45.903 −25.205 1.00 44.01 O ATOM 8657 N PRO C 98 40.124 46.100 −27.361 1.00 48.07 N ATOM 8658 CA PRO C 98 41.434 46.657 −27.076 1.00 49.84 C ATOM 8659 CB PRO C 98 42.226 46.249 −28.323 1.00 47.23 C ATOM 8660 CG PRO C 98 41.244 46.380 −29.408 1.00 45.78 C ATOM 8661 CD PRO C 98 39.888 46.075 −28.815 1.00 46.55 C ATOM 8662 C PRO C 98 41.400 48.200 −26.949 1.00 52.52 C ATOM 8663 O PRO C 98 40.620 48.865 −27.647 1.00 45.29 O ATOM 8664 N LEU C 99 42.227 48.759 −26.058 1.00 56.62 N ATOM 8665 CA LEU C 99 42.241 50.210 −25.862 1.00 56.73 C ATOM 8666 CB LEU C 99 41.387 50.579 −24.678 1.00 53.55 C ATOM 8667 CG LEU C 99 39.968 50.088 −24.755 1.00 53.60 C ATOM 8668 CD1 LEU C 99 39.300 50.185 −23.402 1.00 51.87 C ATOM 8669 CD2 LEU C 99 39.219 50.904 −25.792 1.00 54.54 C ATOM 8670 C LEU C 99 43.609 50.812 −25.651 1.00 59.42 C ATOM 8671 O LEU C 99 44.537 50.130 −25.172 1.00 59.42 O ATOM 8672 N GLN C 100 43.694 52.094 −26.029 1.00 57.80 N ATOM 8673 CA GLN C 100 44.781 52.964 −25.681 1.00 57.91 C ATOM 8674 CB GLN C 100 45.610 53.303 −26.891 1.00 59.36 C ATOM 8675 CG GLN C 100 46.078 52.069 −27.657 1.00 63.95 C ATOM 8676 CD GLN C 100 47.461 52.211 −28.290 1.00 65.36 C ATOM 8677 OE1 GLN C 100 48.431 52.667 −27.649 1.00 70.20 O ATOM 8678 NE2 GLN C 100 47.557 51.819 −29.556 1.00 62.81 N ATOM 8679 C GLN C 100 44.197 54.227 −25.119 1.00 65.09 C ATOM 8680 O GLN C 100 43.375 54.909 −25.770 1.00 70.97 O ATOM 8681 N LEU C 101 44.633 54.532 −23.900 1.00 72.86 N ATOM 8682 CA LEU C 101 44.153 55.673 −23.098 1.00 75.33 C ATOM 8683 CB LEU C 101 43.533 55.127 −21.799 1.00 73.29 C ATOM 8684 CG LEU C 101 42.295 54.278 −22.080 1.00 68.74 C ATOM 8685 CD1 LEU C 101 41.932 53.430 −20.890 1.00 69.18 C ATOM 8686 CD2 LEU C 101 41.115 55.161 −22.454 1.00 68.42 C ATOM 8687 C LEU C 101 45.269 56.691 −22.780 1.00 72.12 C ATOM 8688 O LEU C 101 46.348 56.313 −22.330 1.00 64.55 O ATOM 8689 N PHE C 102 45.003 57.973 −23.017 1.00 76.94 N ATOM 8690 CA PHE C 102 46.013 59.024 −22.785 1.00 81.00 C ATOM 8691 CB PHE C 102 46.298 59.751 −24.089 1.00 79.51 C ATOM 8692 CG PHE C 102 46.637 58.840 −25.209 1.00 76.52 C ATOM 8693 CD1 PHE C 102 47.948 58.438 −25.421 1.00 74.63 C ATOM 8694 CE1 PHE C 102 48.279 57.581 −26.455 1.00 74.84 C ATOM 8695 CZ PHE C 102 47.300 57.104 −27.282 1.00 78.46 C ATOM 8696 CE2 PHE C 102 45.982 57.501 −27.078 1.00 83.77 C ATOM 8697 CD2 PHE C 102 45.652 58.364 −26.040 1.00 79.36 C ATOM 8698 C PHE C 102 45.649 60.033 −21.671 1.00 86.60 C ATOM 8699 O PHE C 102 46.474 60.267 −20.782 1.00 81.13 O ATOM 8700 N HIS C 103 44.435 60.609 −21.704 1.00 93.19 N ATOM 8701 CA HIS C 103 44.027 61.655 −20.737 1.00 101.02 C ATOM 8702 CB HIS C 103 42.606 62.190 −21.008 1.00 109.35 C ATOM 8703 CG HIS C 103 42.485 62.902 −22.326 1.00 121.76 C ATOM 8704 ND1 HIS C 103 41.930 62.317 −23.447 1.00 123.06 N ATOM 8705 CE1 HIS C 103 41.997 63.159 −24.464 1.00 121.27 C ATOM 8706 NE2 HIS C 103 42.576 64.269 −24.045 1.00 128.57 N ATOM 8707 CD2 HIS C 103 42.898 64.133 −22.714 1.00 129.72 C ATOM 8708 C HIS C 103 44.132 61.086 −19.336 1.00 100.09 C ATOM 8709 O HIS C 103 43.489 60.081 −19.055 1.00 100.20 O ATOM 8710 N PRO C 104 44.958 61.714 −18.460 1.00 98.96 N ATOM 8711 CA PRO C 104 45.367 61.121 −17.169 1.00 93.34 C ATOM 8712 CB PRO C 104 46.308 62.164 −16.597 1.00 93.23 C ATOM 8713 CG PRO C 104 45.804 63.449 −17.159 1.00 95.67 C ATOM 8714 CD PRO C 104 45.412 63.116 −18.565 1.00 96.39 C ATOM 8715 C PRO C 104 44.237 60.807 −16.171 1.00 91.50 C ATOM 8716 O PRO C 104 44.461 60.054 −15.236 1.00 90.25 O ATOM 8717 N GLN C 105 43.048 61.369 −16.376 1.00 95.30 N ATOM 8718 CA GLN C 105 41.824 60.908 −15.688 1.00 97.73 C ATOM 8719 CB GLN C 105 40.623 61.815 −16.011 1.00 104.46 C ATOM 8720 CG GLN C 105 40.810 63.328 −16.006 1.00 106.72 C ATOM 8721 CD GLN C 105 39.971 63.941 −17.117 1.00 115.97 C ATOM 8722 OE1 GLN C 105 40.385 63.944 −18.300 1.00 116.31 O ATOM 8723 NE2 GLN C 105 38.768 64.422 −16.757 1.00 118.63 N ATOM 8724 C GLN C 105 41.444 59.449 −16.107 1.00 91.15 C ATOM 8725 O GLN C 105 41.021 58.615 −15.285 1.00 82.50 O ATOM 8726 N GLU C 106 41.559 59.172 −17.408 1.00 87.71 N ATOM 8727 CA GLU C 106 41.345 57.827 −17.951 1.00 79.36 C ATOM 8728 CB GLU C 106 41.399 57.822 −19.480 1.00 75.26 C ATOM 8729 CG GLU C 106 40.420 58.698 −20.245 1.00 71.19 C ATOM 8730 CD GLU C 106 40.693 58.651 −21.758 1.00 72.43 C ATOM 8731 OE1 GLU C 106 41.879 58.521 −22.198 1.00 65.40 O ATOM 8732 OE2 GLU C 106 39.712 58.737 −22.530 1.00 74.16 O ATOM 8733 C GLU C 106 42.446 56.886 −17.428 1.00 77.28 C ATOM 8734 O GLU C 106 42.183 55.798 −16.911 1.00 80.68 O ATOM 8735 N VAL C 107 43.684 57.326 −17.547 1.00 70.42 N ATOM 8736 CA VAL C 107 44.796 56.552 −17.038 1.00 72.37 C ATOM 8737 CB VAL C 107 46.134 57.284 −17.319 1.00 74.96 C ATOM 8738 CG1 VAL C 107 47.340 56.591 −16.661 1.00 75.96 C ATOM 8739 CG2 VAL C 107 46.338 57.446 −18.820 1.00 75.74 C ATOM 8740 C VAL C 107 44.640 56.243 −15.533 1.00 73.46 C ATOM 8741 O VAL C 107 45.076 55.184 −15.068 1.00 70.81 O ATOM 8742 N SER C 108 44.033 57.157 −14.775 1.00 75.71 N ATOM 8743 CA SER C 108 43.815 56.923 −13.349 1.00 80.21 C ATOM 8744 CB SER C 108 43.339 58.191 −12.636 1.00 81.31 C ATOM 8745 OG SER C 108 44.335 59.175 −12.673 1.00 79.93 O ATOM 8746 C SER C 108 42.802 55.827 −13.105 1.00 83.19 C ATOM 8747 O SER C 108 43.125 54.802 −12.524 1.00 88.52 O ATOM 8748 N MET C 109 41.574 56.037 −13.551 1.00 82.02 N ATOM 8749 CA MET C 109 40.511 55.145 −13.144 1.00 85.87 C ATOM 8750 CB MET C 109 39.148 55.784 −13.420 1.00 91.14 C ATOM 8751 CG MET C 109 38.790 55.872 −14.888 1.00 94.00 C ATOM 8752 SD MET C 109 37.654 54.537 −15.281 1.00 94.36 S ATOM 8753 CE MET C 109 38.314 53.950 −16.841 1.00 94.78 C ATOM 8754 C MET C 109 40.656 53.725 −13.740 1.00 77.83 C ATOM 8755 O MET C 109 39.974 52.804 −13.284 1.00 79.05 O ATOM 8756 N VAL C 110 41.538 53.537 −14.723 1.00 67.18 N ATOM 8757 CA VAL C 110 41.897 52.184 −15.143 1.00 66.91 C ATOM 8758 CB VAL C 110 42.539 52.129 −16.548 1.00 62.80 C ATOM 8759 CG1 VAL C 110 43.044 50.731 −16.884 1.00 60.13 C ATOM 8760 CG2 VAL C 110 41.498 52.487 −17.563 1.00 63.27 C ATOM 8761 C VAL C 110 42.813 51.592 −14.093 1.00 67.12 C ATOM 8762 O VAL C 110 42.506 50.563 −13.497 1.00 69.70 O ATOM 8763 N ARG C 111 43.928 52.267 −13.869 1.00 69.84 N ATOM 8764 CA ARG C 111 44.844 51.984 −12.751 1.00 68.08 C ATOM 8765 CB ARG C 111 45.799 53.192 −12.560 1.00 72.31 C ATOM 8766 CG ARG C 111 47.103 52.930 −11.819 1.00 80.66 C ATOM 8767 CD ARG C 111 48.191 53.949 −12.207 1.00 82.86 C ATOM 8768 NE ARG C 111 48.861 53.572 −13.458 1.00 84.22 N ATOM 8769 CZ ARG C 111 49.741 54.314 −14.122 1.00 79.47 C ATOM 8770 NH1 ARG C 111 50.065 55.525 −13.689 1.00 72.93 N ATOM 8771 NH2 ARG C 111 50.283 53.833 −15.248 1.00 84.80 N ATOM 8772 C ARG C 111 44.050 51.607 −11.466 1.00 60.60 C ATOM 8773 O ARG C 111 44.395 50.594 −10.806 1.00 52.87 O ATOM 8774 N ASN C 112 42.967 52.371 −11.181 1.00 56.14 N ATOM 8775 CA ASN C 112 42.084 52.107 −10.052 1.00 55.28 C ATOM 8776 CB ASN C 112 41.019 53.177 −9.838 1.00 56.03 C ATOM 8777 CG ASN C 112 40.258 52.970 −8.503 1.00 59.66 C ATOM 8778 OD1 ASN C 112 40.805 53.239 −7.441 1.00 65.90 O ATOM 8779 ND2 ASN C 112 39.017 52.467 −8.554 1.00 58.09 N ATOM 8780 C ASN C 112 41.353 50.813 −10.223 1.00 59.19 C ATOM 8781 O ASN C 112 41.291 50.002 −9.308 1.00 62.35 O ATOM 8782 N LEU C 113 40.740 50.652 −11.388 1.00 63.01 N ATOM 8783 CA LEU C 113 39.932 49.473 −11.688 1.00 59.91 C ATOM 8784 CB LEU C 113 39.360 49.550 −13.098 1.00 63.19 C ATOM 8785 CG LEU C 113 37.844 49.651 −13.235 1.00 63.66 C ATOM 8786 CD1 LEU C 113 37.113 50.279 −12.027 1.00 64.23 C ATOM 8787 CD2 LEU C 113 37.576 50.319 −14.585 1.00 57.39 C ATOM 8788 C LEU C 113 40.707 48.209 −11.545 1.00 58.61 C ATOM 8789 O LEU C 113 40.184 47.278 −10.982 1.00 61.35 O ATOM 8790 N ILE C 114 41.949 48.214 −11.959 1.00 57.42 N ATOM 8791 CA ILE C 114 42.744 47.029 −11.874 1.00 60.47 C ATOM 8792 CB ILE C 114 44.170 47.346 −12.244 1.00 65.98 C ATOM 8793 CG1 ILE C 114 44.202 48.122 −13.540 1.00 69.16 C ATOM 8794 CD1 ILE C 114 44.006 47.271 −14.757 1.00 72.50 C ATOM 8795 CG2 ILE C 114 44.968 46.073 −12.357 1.00 67.53 C ATOM 8796 C ILE C 114 42.771 46.595 −10.447 1.00 63.85 C ATOM 8797 O ILE C 114 42.743 45.422 −10.153 1.00 61.10 O ATOM 8798 N GLN C 115 42.844 47.555 −9.552 1.00 68.20 N ATOM 8799 CA GLN C 115 42.858 47.248 −8.147 1.00 66.00 C ATOM 8800 CB GLN C 115 43.074 48.506 −7.342 1.00 71.71 C ATOM 8801 CG GLN C 115 44.418 49.145 −7.565 1.00 73.42 C ATOM 8802 CD GLN C 115 45.516 48.136 −7.650 1.00 73.16 C ATOM 8803 OE1 GLN C 115 45.762 47.576 −8.701 1.00 68.71 O ATOM 8804 NE2 GLN C 115 46.172 47.887 −6.540 1.00 75.49 N ATOM 8805 C GLN C 115 41.578 46.597 −7.713 1.00 70.81 C ATOM 8806 O GLN C 115 41.590 45.713 −6.881 1.00 61.77 O ATOM 8807 N LYS C 116 40.462 47.057 −8.246 1.00 84.66 N ATOM 8808 CA LYS C 116 39.194 46.487 −7.853 1.00 86.87 C ATOM 8809 CB LYS C 116 38.514 47.498 −6.936 1.00 84.54 C ATOM 8810 C LYS C 116 38.216 46.118 −8.958 1.00 80.07 C ATOM 8811 O LYS C 116 37.894 46.947 −9.777 1.00 94.73 O ATOM 8812 N ASP C 117 37.710 44.896 −8.982 1.00 66.54 N ATOM 8813 CA ASP C 117 36.682 44.540 −9.965 1.00 65.77 C ATOM 8814 CB ASP C 117 35.420 45.341 −9.722 1.00 71.42 C ATOM 8815 CG ASP C 117 34.748 44.964 −8.414 1.00 74.10 C ATOM 8816 OD1 ASP C 117 35.316 44.151 −7.666 1.00 70.16 O ATOM 8817 OD2 ASP C 117 33.653 45.479 −8.127 1.00 76.74 O ATOM 8818 C ASP C 117 37.079 44.442 −11.436 1.00 60.14 C ATOM 8819 O ASP C 117 36.860 43.429 −12.047 1.00 53.50 O ATOM 8820 N ARG C 118 37.639 45.481 −12.020 1.00 57.96 N ATOM 8821 CA ARG C 118 38.129 45.348 −13.374 1.00 56.80 C ATOM 8822 CB ARG C 118 38.939 44.064 −13.548 1.00 59.80 C ATOM 8823 CG ARG C 118 40.313 44.055 −12.849 1.00 63.98 C ATOM 8824 CD ARG C 118 41.261 42.920 −13.285 1.00 64.54 C ATOM 8825 NE ARG C 118 40.450 41.744 −13.577 1.00 65.34 N ATOM 8826 CZ ARG C 118 39.896 40.957 −12.675 1.00 64.51 C ATOM 8827 NH1 ARG C 118 40.162 41.138 −11.387 1.00 66.68 N ATOM 8828 NH2 ARG C 118 39.100 39.957 −13.075 1.00 68.09 N ATOM 8829 C ARG C 118 37.071 45.566 −14.499 1.00 58.53 C ATOM 8830 O ARG C 118 37.455 45.816 −15.638 1.00 58.86 O ATOM 8831 N THR C 119 35.775 45.524 −14.190 1.00 57.64 N ATOM 8832 CA THR C 119 34.723 45.873 −15.153 1.00 61.67 C ATOM 8833 CB THR C 119 33.411 45.191 −14.752 1.00 68.60 C ATOM 8834 OG1 THR C 119 33.174 45.526 −13.379 1.00 85.66 O ATOM 8835 CG2 THR C 119 33.480 43.601 −14.921 1.00 66.58 C ATOM 8836 C THR C 119 34.441 47.392 −15.328 1.00 56.20 C ATOM 8837 O THR C 119 34.659 48.189 −14.464 1.00 57.06 O ATOM 8838 N PHE C 120 33.956 47.761 −16.489 1.00 56.80 N ATOM 8839 CA PHE C 120 33.539 49.110 −16.792 1.00 56.08 C ATOM 8840 CB PHE C 120 34.691 49.986 −17.293 1.00 56.91 C ATOM 8841 CG PHE C 120 35.332 49.521 −18.555 1.00 60.93 C ATOM 8842 CD1 PHE C 120 34.807 49.871 −19.795 1.00 66.54 C ATOM 8843 CE1 PHE C 120 35.425 49.439 −20.973 1.00 66.64 C ATOM 8844 CZ PHE C 120 36.591 48.676 −20.913 1.00 64.04 C ATOM 8845 CE2 PHE C 120 37.133 48.351 −19.686 1.00 62.34 C ATOM 8846 CD2 PHE C 120 36.507 48.778 −18.521 1.00 64.24 C ATOM 8847 C PHE C 120 32.360 49.073 −17.766 1.00 56.75 C ATOM 8848 O PHE C 120 31.965 48.010 −18.258 1.00 57.69 O ATOM 8849 N ALA C 121 31.787 50.235 −18.030 1.00 56.48 N ATOM 8850 CA ALA C 121 30.583 50.313 −18.809 1.00 56.14 C ATOM 8851 CB ALA C 121 29.492 51.017 −18.029 1.00 55.99 C ATOM 8852 C ALA C 121 30.848 50.976 −20.154 1.00 55.81 C ATOM 8853 O ALA C 121 31.551 51.974 −20.272 1.00 53.32 O ATOM 8854 N VAL C 122 30.287 50.350 −21.176 1.00 56.67 N ATOM 8855 CA VAL C 122 30.471 50.754 −22.524 1.00 54.96 C ATOM 8856 CB VAL C 122 31.071 49.617 −23.326 1.00 51.63 C ATOM 8857 CG1 VAL C 122 31.039 49.968 −24.794 1.00 52.18 C ATOM 8858 CG2 VAL C 122 32.476 49.270 −22.842 1.00 49.49 C ATOM 8859 C VAL C 122 29.068 51.028 −22.990 1.00 59.96 C ATOM 8860 O VAL C 122 28.299 50.107 −23.231 1.00 54.94 O ATOM 8861 N LEU C 123 28.742 52.312 −23.102 1.00 70.33 N ATOM 8862 CA LEU C 123 27.368 52.733 −23.346 1.00 71.60 C ATOM 8863 CB LEU C 123 27.133 54.127 −22.763 1.00 71.76 C ATOM 8864 CG LEU C 123 27.347 54.171 −21.243 1.00 74.66 C ATOM 8865 CD1 LEU C 123 27.158 55.573 −20.679 1.00 75.65 C ATOM 8866 CD2 LEU C 123 26.428 53.196 −20.498 1.00 73.40 C ATOM 8867 C LEU C 123 27.080 52.709 −24.822 1.00 73.31 C ATOM 8868 O LEU C 123 27.943 53.094 −25.610 1.00 67.70 O ATOM 8869 N ALA C 124 25.876 52.226 −25.158 1.00 81.79 N ATOM 8870 CA ALA C 124 25.333 52.154 −26.526 1.00 89.93 C ATOM 8871 CB ALA C 124 24.566 50.852 −26.757 1.00 86.74 C ATOM 8872 C ALA C 124 24.390 53.315 −26.657 1.00 99.46 C ATOM 8873 O ALA C 124 23.439 53.420 −25.886 1.00 95.83 O ATOM 8874 N TYR C 125 24.619 54.164 −27.657 1.00 114.66 N ATOM 8875 CA TYR C 125 24.128 55.547 −27.606 1.00 119.11 C ATOM 8876 CB TYR C 125 25.216 56.469 −28.152 1.00 115.61 C ATOM 8877 CG TYR C 125 26.319 56.721 −27.134 1.00 114.02 C ATOM 8878 CD1 TYR C 125 26.046 57.404 −25.936 1.00 111.48 C ATOM 8879 CE1 TYR C 125 27.047 57.655 −24.989 1.00 106.86 C ATOM 8880 CZ TYR C 125 28.349 57.230 −25.230 1.00 106.36 C ATOM 8881 OH TYR C 125 29.325 57.475 −24.292 1.00 89.59 O ATOM 8882 CE2 TYR C 125 28.648 56.548 −26.410 1.00 114.61 C ATOM 8883 CD2 TYR C 125 27.636 56.294 −27.356 1.00 117.25 C ATOM 8884 C TYR C 125 22.746 55.856 −28.220 1.00 127.46 C ATOM 8885 O TYR C 125 22.286 55.149 −29.126 1.00 126.34 O ATOM 8886 N SER C 126 22.134 56.935 −27.688 1.00 135.63 N ATOM 8887 CA SER C 126 20.735 57.397 −27.933 1.00 135.87 C ATOM 8888 CB SER C 126 20.707 58.948 −27.977 1.00 124.42 C ATOM 8889 C SER C 126 19.984 56.814 −29.153 1.00 130.79 C ATOM 8890 O SER C 126 20.331 57.078 −30.312 1.00 126.37 O ATOM 8891 N GLU C 132 23.569 61.132 −22.953 1.00 127.81 N ATOM 8892 CA GLU C 132 23.277 59.920 −22.197 1.00 125.87 C ATOM 8893 CB GLU C 132 22.448 60.250 −20.941 1.00 111.40 C ATOM 8894 C GLU C 132 22.580 58.859 −23.095 1.00 138.28 C ATOM 8895 O GLU C 132 22.299 59.111 −24.299 1.00 134.18 O ATOM 8896 N ALA C 133 22.359 57.669 −22.508 1.00 140.67 N ATOM 8897 CA ALA C 133 21.732 56.505 −23.188 1.00 127.06 C ATOM 8898 CB ALA C 133 22.730 55.791 −24.088 1.00 125.01 C ATOM 8899 C ALA C 133 21.135 55.528 −22.173 1.00 113.54 C ATOM 8900 O ALA C 133 21.267 55.730 −20.964 1.00 105.95 O ATOM 8901 N GLN C 134 20.495 54.475 −22.675 1.00 104.75 N ATOM 8902 CA GLN C 134 19.594 53.653 −21.859 1.00 106.65 C ATOM 8903 CB GLN C 134 18.156 53.660 −22.433 1.00 114.91 C ATOM 8904 CG GLN C 134 17.739 54.894 −23.257 1.00 121.57 C ATOM 8905 CD GLN C 134 18.255 54.889 −24.712 1.00 130.61 C ATOM 8906 OE1 GLN C 134 18.452 53.831 −25.320 1.00 137.07 O ATOM 8907 NE2 GLN C 134 18.485 56.078 −25.266 1.00 130.54 N ATOM 8908 C GLN C 134 20.083 52.210 −21.681 1.00 100.53 C ATOM 8909 O GLN C 134 19.774 51.601 −20.640 1.00 93.20 O ATOM 8910 N PHE C 135 20.821 51.677 −22.676 1.00 92.43 N ATOM 8911 CA PHE C 135 21.357 50.291 −22.672 1.00 88.03 C ATOM 8912 CB PHE C 135 20.616 49.424 −23.698 1.00 91.59 C ATOM 8913 CG PHE C 135 19.154 49.294 −23.404 1.00 105.54 C ATOM 8914 CD1 PHE C 135 18.721 48.574 −22.288 1.00 108.02 C ATOM 8915 CE1 PHE C 135 17.369 48.475 −21.983 1.00 110.27 C ATOM 8916 CZ PHE C 135 16.427 49.107 −22.790 1.00 115.33 C ATOM 8917 CE2 PHE C 135 16.841 49.840 −23.896 1.00 114.60 C ATOM 8918 CD2 PHE C 135 18.199 49.940 −24.197 1.00 113.35 C ATOM 8919 C PHE C 135 22.861 50.213 −22.937 1.00 80.98 C ATOM 8920 O PHE C 135 23.417 51.020 −23.654 1.00 83.24 O ATOM 8921 N GLY C 136 23.532 49.237 −22.346 1.00 75.98 N ATOM 8922 CA GLY C 136 24.946 49.036 −22.627 1.00 68.27 C ATOM 8923 C GLY C 136 25.390 47.684 −22.153 1.00 64.41 C ATOM 8924 O GLY C 136 24.556 46.884 −21.709 1.00 69.67 O ATOM 8925 N THR C 137 26.699 47.445 −22.232 1.00 56.65 N ATOM 8926 CA THR C 137 27.290 46.158 −21.928 1.00 52.73 C ATOM 8927 CB THR C 137 27.684 45.442 −23.230 1.00 52.24 C ATOM 8928 OG1 THR C 137 26.499 45.126 −23.971 1.00 51.42 O ATOM 8929 CG2 THR C 137 28.419 44.140 −22.962 1.00 52.83 C ATOM 8930 C THR C 137 28.515 46.365 −21.078 1.00 51.53 C ATOM 8931 O THR C 137 29.267 47.293 −21.345 1.00 49.57 O ATOM 8932 N THR C 138 28.721 45.506 −20.066 1.00 51.08 N ATOM 8933 CA THR C 138 29.945 45.557 −19.237 1.00 50.51 C ATOM 8934 CB THR C 138 29.862 44.761 −17.929 1.00 51.67 C ATOM 8935 OG1 THR C 138 29.825 43.346 −18.193 1.00 53.04 O ATOM 8936 CG2 THR C 138 28.661 45.188 −17.128 1.00 52.63 C ATOM 8937 C THR C 138 31.179 45.038 −19.946 1.00 51.19 C ATOM 8938 O THR C 138 31.109 44.163 −20.787 1.00 49.29 O ATOM 8939 N ALA C 139 32.331 45.561 −19.581 1.00 52.10 N ATOM 8940 CA ALA C 139 33.570 45.036 −20.132 1.00 54.12 C ATOM 8941 CB ALA C 139 34.138 45.992 −21.172 1.00 53.88 C ATOM 8942 C ALA C 139 34.569 44.819 −19.010 1.00 54.11 C ATOM 8943 O ALA C 139 34.867 45.743 −18.304 1.00 54.10 O ATOM 8944 N GLU C 140 35.103 43.609 −18.887 1.00 54.57 N ATOM 8945 CA GLU C 140 36.150 43.302 −17.936 1.00 55.37 C ATOM 8946 CB GLU C 140 35.928 41.909 −17.379 1.00 62.00 C ATOM 8947 CG GLU C 140 36.715 41.597 −16.135 1.00 66.51 C ATOM 8948 CD GLU C 140 36.571 40.150 −15.702 1.00 71.67 C ATOM 8949 OE1 GLU C 140 35.433 39.625 −15.696 1.00 68.63 O ATOM 8950 OE2 GLU C 140 37.610 39.541 −15.351 1.00 86.32 O ATOM 8951 C GLU C 140 37.525 43.387 −18.587 1.00 52.66 C ATOM 8952 O GLU C 140 37.728 42.943 −19.705 1.00 46.81 O ATOM 8953 N ILE C 141 38.455 43.964 −17.839 1.00 54.60 N ATOM 8954 CA ILE C 141 39.841 44.076 −18.235 1.00 55.91 C ATOM 8955 CB ILE C 141 40.567 45.188 −17.474 1.00 56.05 C ATOM 8956 CG1 ILE C 141 39.959 46.522 −17.866 1.00 56.86 C ATOM 8957 CD1 ILE C 141 40.333 47.653 −16.955 1.00 59.81 C ATOM 8958 CG2 ILE C 141 42.044 45.216 −17.852 1.00 57.38 C ATOM 8959 C ILE C 141 40.526 42.779 −17.930 1.00 55.65 C ATOM 8960 O ILE C 141 40.474 42.308 −16.797 1.00 53.39 O ATOM 8961 N TYR C 142 41.152 42.193 −18.943 1.00 55.99 N ATOM 8962 CA TYR C 142 41.907 40.944 −18.733 1.00 56.17 C ATOM 8963 CB TYR C 142 41.313 39.743 −19.515 1.00 51.59 C ATOM 8964 CG TYR C 142 41.502 39.783 −21.037 1.00 48.06 C ATOM 8965 CD1 TYR C 142 42.703 39.407 −21.618 1.00 44.97 C ATOM 8966 CE1 TYR C 142 42.899 39.478 −22.976 1.00 44.13 C ATOM 8967 CZ TYR C 142 41.877 39.891 −23.803 1.00 44.01 C ATOM 8968 OH TYR C 142 42.098 39.899 −25.143 1.00 41.70 O ATOM 8969 CE2 TYR C 142 40.657 40.261 −23.278 1.00 46.78 C ATOM 8970 CD2 TYR C 142 40.471 40.214 −21.892 1.00 48.61 C ATOM 8971 C TYR C 142 43.376 41.107 −19.037 1.00 56.57 C ATOM 8972 O TYR C 142 44.091 40.161 −18.838 1.00 57.96 O ATOM 8973 N ALA C 143 43.827 42.271 −19.516 1.00 57.50 N ATOM 8974 CA ALA C 143 45.276 42.524 −19.651 1.00 61.88 C ATOM 8975 CB ALA C 143 45.779 41.878 −20.926 1.00 61.36 C ATOM 8976 C ALA C 143 45.692 44.040 −19.545 1.00 65.23 C ATOM 8977 O ALA C 143 45.049 44.903 −20.115 1.00 66.06 O ATOM 8978 N TYR C 144 46.736 44.354 −18.784 1.00 70.28 N ATOM 8979 CA TYR C 144 47.058 45.751 −18.449 1.00 78.93 C ATOM 8980 CB TYR C 144 46.916 46.020 −16.928 1.00 89.92 C ATOM 8981 CG TYR C 144 47.613 47.305 −16.411 1.00 105.21 C ATOM 8982 CD1 TYR C 144 47.220 48.585 −16.863 1.00 110.88 C ATOM 8983 CE1 TYR C 144 47.854 49.754 −16.407 1.00 111.98 C ATOM 8984 CZ TYR C 144 48.901 49.668 −15.486 1.00 112.15 C ATOM 8985 OH TYR C 144 49.522 50.826 −15.054 1.00 104.71 O ATOM 8986 CE2 TYR C 144 49.311 48.415 −15.020 1.00 113.02 C ATOM 8987 CD2 TYR C 144 48.669 47.245 −15.475 1.00 110.93 C ATOM 8988 C TYR C 144 48.472 45.991 −18.893 1.00 77.08 C ATOM 8989 O TYR C 144 49.285 45.065 −18.840 1.00 74.18 O ATOM 8990 N ARG C 145 48.756 47.227 −19.316 1.00 76.77 N ATOM 8991 CA ARG C 145 50.093 47.652 −19.748 1.00 83.67 C ATOM 8992 CB ARG C 145 50.282 47.393 −21.252 1.00 93.21 C ATOM 8993 CG ARG C 145 51.524 46.626 −21.635 1.00 99.74 C ATOM 8994 CD ARG C 145 52.791 47.387 −21.310 1.00 107.37 C ATOM 8995 NE ARG C 145 53.367 48.085 −22.461 1.00 110.28 N ATOM 8996 CZ ARG C 145 53.985 47.498 −23.485 1.00 104.41 C ATOM 8997 NH1 ARG C 145 54.500 48.268 −24.428 1.00 104.57 N ATOM 8998 NH2 ARG C 145 54.083 46.161 −23.582 1.00 102.27 N ATOM 8999 C ARG C 145 50.254 49.144 −19.489 1.00 88.06 C ATOM 9000 O ARG C 145 49.584 49.957 −20.141 1.00 89.69 O ATOM 9001 N GLU C 146 51.107 49.502 −18.520 1.00 96.33 N ATOM 9002 CA GLU C 146 51.553 50.895 −18.312 1.00 89.58 C ATOM 9003 CB GLU C 146 51.891 51.184 −16.828 1.00 79.82 C ATOM 9004 C GLU C 146 52.751 51.080 −19.252 1.00 85.81 C ATOM 9005 O GLU C 146 53.480 50.129 −19.544 1.00 77.18 O ATOM 9006 N GLU C 147 52.913 52.284 −19.776 1.00 90.31 N ATOM 9007 CA GLU C 147 54.075 52.581 −20.591 1.00 97.81 C ATOM 9008 CB GLU C 147 53.911 51.908 −21.965 1.00 98.02 C ATOM 9009 CG GLU C 147 54.426 52.662 −23.184 1.00 99.84 C ATOM 9010 CD GLU C 147 54.794 51.699 −24.291 1.00 102.95 C ATOM 9011 OE1 GLU C 147 53.882 51.056 −24.867 1.00 98.08 O ATOM 9012 OE2 GLU C 147 56.009 51.560 −24.553 1.00 107.97 O ATOM 9013 C GLU C 147 54.360 54.091 −20.640 1.00 104.58 C ATOM 9014 O GLU C 147 53.502 54.864 −21.044 1.00 104.80 O ATOM 9015 N GLN C 148 55.561 54.486 −20.190 1.00 120.25 N ATOM 9016 CA GLN C 148 55.976 55.910 −20.061 1.00 123.72 C ATOM 9017 CB GLN C 148 56.222 56.341 −18.584 1.00 121.73 C ATOM 9018 CG GLN C 148 56.116 55.260 −17.491 1.00 126.98 C ATOM 9019 CD GLN C 148 54.680 54.803 −17.151 1.00 130.08 C ATOM 9020 OE1 GLN C 148 53.716 55.573 −17.253 1.00 130.71 O ATOM 9021 NE2 GLN C 148 54.543 53.539 −16.729 1.00 127.97 N ATOM 9022 C GLN C 148 57.178 56.227 −20.960 1.00 125.29 C ATOM 9023 O GLN C 148 57.932 57.148 −20.674 1.00 119.48 O ATOM 9024 N ASP C 149 57.304 55.472 −22.063 1.00 137.08 N ATOM 9025 CA ASP C 149 58.374 55.621 −23.072 1.00 141.99 C ATOM 9026 CB ASP C 149 58.636 54.294 −23.823 1.00 145.84 C ATOM 9027 CG ASP C 149 59.026 53.129 −22.894 1.00 146.74 C ATOM 9028 OD1 ASP C 149 59.551 53.366 −21.779 1.00 146.59 O ATOM 9029 OD2 ASP C 149 58.807 51.962 −23.300 1.00 137.75 O ATOM 9030 C ASP C 149 58.010 56.699 −24.097 1.00 140.44 C ATOM 9031 O ASP C 149 56.827 56.951 −24.348 1.00 129.16 O ATOM 9032 N PHE C 150 59.046 57.282 −24.709 1.00 146.42 N ATOM 9033 CA PHE C 150 58.984 58.587 −25.402 1.00 148.83 C ATOM 9034 CB PHE C 150 57.988 58.599 −26.603 1.00 152.62 C ATOM 9035 CG PHE C 150 58.160 57.476 −27.624 1.00 152.24 C ATOM 9036 CD1 PHE C 150 59.420 56.976 −27.981 1.00 148.43 C ATOM 9037 CE1 PHE C 150 59.539 55.975 −28.944 1.00 144.37 C ATOM 9038 CZ PHE C 150 58.403 55.478 −29.584 1.00 143.63 C ATOM 9039 CE2 PHE C 150 57.146 55.976 −29.263 1.00 141.95 C ATOM 9040 CD2 PHE C 150 57.028 56.972 −28.300 1.00 146.88 C ATOM 9041 C PHE C 150 58.644 59.766 −24.436 1.00 147.25 C ATOM 9042 O PHE C 150 58.134 60.801 −24.887 1.00 146.24 O ATOM 9043 N GLY C 151 58.910 59.614 −23.127 1.00 143.07 N ATOM 9044 CA GLY C 151 58.541 60.619 −22.099 1.00 142.82 C ATOM 9045 C GLY C 151 57.099 60.614 −21.561 1.00 149.96 C ATOM 9046 O GLY C 151 56.889 60.794 −20.351 1.00 135.25 O ATOM 9047 N ILE C 152 56.122 60.380 −22.452 1.00 159.20 N ATOM 9048 CA ILE C 152 54.664 60.597 −22.211 1.00 154.27 C ATOM 9049 CB ILE C 152 53.928 61.024 −23.535 1.00 145.41 C ATOM 9050 CG1 ILE C 152 54.778 62.021 −24.358 1.00 138.15 C ATOM 9051 CD1 ILE C 152 55.101 61.528 −25.751 1.00 133.32 C ATOM 9052 CG2 ILE C 152 52.536 61.614 −23.260 1.00 137.36 C ATOM 9053 C ILE C 152 53.993 59.325 −21.630 1.00 148.12 C ATOM 9054 O ILE C 152 54.533 58.222 −21.754 1.00 141.52 O ATOM 9055 N GLU C 153 52.837 59.501 −20.981 1.00 139.09 N ATOM 9056 CA GLU C 153 52.009 58.396 −20.452 1.00 130.96 C ATOM 9057 CB GLU C 153 51.103 58.922 −19.341 1.00 125.53 C ATOM 9058 CG GLU C 153 51.818 59.365 −18.087 1.00 122.50 C ATOM 9059 CD GLU C 153 51.827 58.286 −17.032 1.00 125.87 C ATOM 9060 OE1 GLU C 153 50.816 57.556 −16.932 1.00 126.32 O ATOM 9061 OE2 GLU C 153 52.836 58.173 −16.301 1.00 124.46 O ATOM 9062 C GLU C 153 51.088 57.741 −21.510 1.00 128.54 C ATOM 9063 O GLU C 153 50.519 58.430 −22.373 1.00 128.49 O ATOM 9064 N ILE C 154 50.942 56.417 −21.424 1.00 113.81 N ATOM 9065 CA ILE C 154 49.927 55.663 −22.175 1.00 102.62 C ATOM 9066 CB ILE C 154 50.440 54.986 −23.507 1.00 110.36 C ATOM 9067 CG1 ILE C 154 51.683 55.645 −24.148 1.00 109.97 C ATOM 9068 CD1 ILE C 154 51.416 56.803 −25.085 1.00 112.69 C ATOM 9069 CG2 ILE C 154 49.307 54.837 −24.534 1.00 115.44 C ATOM 9070 C ILE C 154 49.505 54.521 −21.247 1.00 92.75 C ATOM 9071 O ILE C 154 50.339 53.997 −20.511 1.00 89.63 O ATOM 9072 N VAL C 155 48.226 54.139 −21.278 1.00 88.59 N ATOM 9073 CA VAL C 155 47.774 52.820 −20.751 1.00 82.70 C ATOM 9074 CB VAL C 155 46.734 52.951 −19.629 1.00 78.41 C ATOM 9075 CG1 VAL C 155 46.211 51.579 −19.221 1.00 78.70 C ATOM 9076 CG2 VAL C 155 47.380 53.634 −18.449 1.00 76.40 C ATOM 9077 C VAL C 155 47.197 51.958 −21.870 1.00 72.91 C ATOM 9078 O VAL C 155 46.523 52.452 −22.758 1.00 72.16 O ATOM 9079 N LYS C 156 47.455 50.668 −21.820 1.00 64.00 N ATOM 9080 CA LYS C 156 46.923 49.798 −22.832 1.00 62.40 C ATOM 9081 CB LYS C 156 48.051 49.279 −23.707 1.00 60.67 C ATOM 9082 CG LYS C 156 48.746 50.386 −24.480 1.00 61.31 C ATOM 9083 CD LYS C 156 50.108 49.897 −24.899 1.00 64.48 C ATOM 9084 CE LYS C 156 50.833 50.929 −25.729 1.00 66.41 C ATOM 9085 NZ LYS C 156 50.551 50.686 −27.169 1.00 71.08 N ATOM 9086 C LYS C 156 46.153 48.683 −22.166 1.00 60.21 C ATOM 9087 O LYS C 156 46.733 47.844 −21.486 1.00 58.31 O ATOM 9088 N VAL C 157 44.842 48.648 −22.366 1.00 61.25 N ATOM 9089 CA VAL C 157 44.083 47.472 −21.898 1.00 64.62 C ATOM 9090 CB VAL C 157 42.957 47.854 −20.920 1.00 67.54 C ATOM 9091 CG1 VAL C 157 43.550 48.517 −19.691 1.00 72.30 C ATOM 9092 CG2 VAL C 157 41.998 48.816 −21.552 1.00 70.49 C ATOM 9093 C VAL C 157 43.592 46.525 −23.006 1.00 59.21 C ATOM 9094 O VAL C 157 43.615 46.845 −24.219 1.00 59.83 O ATOM 9095 N LYS C 158 43.221 45.334 −22.563 1.00 51.90 N ATOM 9096 CA LYS C 158 42.378 44.438 −23.355 1.00 54.75 C ATOM 9097 CB LYS C 158 43.139 43.206 −23.837 1.00 54.01 C ATOM 9098 CG LYS C 158 44.201 43.588 −24.822 1.00 53.89 C ATOM 9099 CD LYS C 158 44.785 42.398 −25.512 1.00 53.73 C ATOM 9100 CE LYS C 158 45.795 41.685 −24.634 1.00 57.77 C ATOM 9101 NZ LYS C 158 46.933 41.205 −25.490 1.00 60.40 N ATOM 9102 C LYS C 158 41.181 44.029 −22.525 1.00 52.89 C ATOM 9103 O LYS C 158 41.300 43.238 −21.588 1.00 55.21 O ATOM 9104 N ALA C 159 40.030 44.606 −22.827 1.00 50.67 N ATOM 9105 CA ALA C 159 38.848 44.233 −22.102 1.00 50.67 C ATOM 9106 CB ALA C 159 38.053 45.463 −21.768 1.00 49.40 C ATOM 9107 C ALA C 159 38.002 43.174 −22.877 1.00 49.97 C ATOM 9108 O ALA C 159 38.267 42.834 −24.036 1.00 48.21 O ATOM 9109 N ILE C 160 36.994 42.638 −22.227 1.00 44.50 N ATOM 9110 CA ILE C 160 36.127 41.767 −22.929 1.00 44.82 C ATOM 9111 CB ILE C 160 36.566 40.309 −22.810 1.00 46.38 C ATOM 9112 CG1 ILE C 160 35.487 39.382 −23.324 1.00 44.43 C ATOM 9113 CD1 ILE C 160 36.030 38.020 −23.605 1.00 45.53 C ATOM 9114 CG2 ILE C 160 36.849 39.933 −21.371 1.00 48.37 C ATOM 9115 C ILE C 160 34.768 41.985 −22.333 1.00 46.74 C ATOM 9116 O ILE C 160 34.614 41.993 −21.112 1.00 41.89 O ATOM 9117 N GLY C 161 33.789 42.180 −23.227 1.00 48.67 N ATOM 9118 CA GLY C 161 32.430 42.478 −22.851 1.00 46.57 C ATOM 9119 C GLY C 161 31.975 41.251 −22.131 1.00 47.10 C ATOM 9120 O GLY C 161 32.490 40.191 −22.393 1.00 43.65 O ATOM 9121 N ARG C 162 31.043 41.415 −21.211 1.00 50.82 N ATOM 9122 CA ARG C 162 30.563 40.353 −20.347 1.00 51.39 C ATOM 9123 CB ARG C 162 31.225 40.484 −18.985 1.00 51.47 C ATOM 9124 CG ARG C 162 32.665 39.988 −18.968 1.00 53.83 C ATOM 9125 CD ARG C 162 32.774 38.499 −18.663 1.00 57.05 C ATOM 9126 NE ARG C 162 33.762 37.736 −19.472 1.00 61.84 N ATOM 9127 CZ ARG C 162 35.060 37.538 −19.165 1.00 68.56 C ATOM 9128 NH1 ARG C 162 35.625 38.076 −18.071 1.00 71.34 N ATOM 9129 NH2 ARG C 162 35.825 36.795 −19.974 1.00 69.40 N ATOM 9130 C ARG C 162 29.034 40.390 −20.259 1.00 52.86 C ATOM 9131 O ARG C 162 28.387 39.518 −20.824 1.00 58.20 O ATOM 9132 N GLN C 163 28.453 41.393 −19.600 1.00 50.90 N ATOM 9133 CA GLN C 163 27.006 41.424 −19.402 1.00 52.14 C ATOM 9134 CB GLN C 163 26.709 41.371 −17.933 1.00 52.93 C ATOM 9135 CG GLN C 163 27.187 40.111 −17.251 1.00 54.26 C ATOM 9136 CD GLN C 163 27.434 40.326 −15.777 1.00 53.47 C ATOM 9137 OE1 GLN C 163 28.292 41.164 −15.348 1.00 55.13 O ATOM 9138 NE2 GLN C 163 26.679 39.599 −14.984 1.00 50.83 N ATOM 9139 C GLN C 163 26.287 42.639 −19.957 1.00 54.30 C ATOM 9140 O GLN C 163 26.837 43.734 −19.954 1.00 55.57 O ATOM 9141 N ARG C 164 25.034 42.438 −20.373 1.00 56.04 N ATOM 9142 CA ARG C 164 24.176 43.537 −20.796 1.00 59.51 C ATOM 9143 CB ARG C 164 23.041 43.042 −21.704 1.00 63.23 C ATOM 9144 CG ARG C 164 23.431 42.553 −23.111 1.00 65.83 C ATOM 9145 CD ARG C 164 22.215 42.022 −23.872 1.00 67.76 C ATOM 9146 NE ARG C 164 21.578 41.012 −23.022 1.00 74.42 N ATOM 9147 CZ ARG C 164 20.281 40.712 −22.940 1.00 77.37 C ATOM 9148 NH1 ARG C 164 19.354 41.291 −23.710 1.00 80.85 N ATOM 9149 NH2 ARG C 164 19.919 39.772 −22.071 1.00 79.02 N ATOM 9150 C ARG C 164 23.542 44.236 −19.588 1.00 61.53 C ATOM 9151 O ARG C 164 23.196 43.596 −18.568 1.00 60.73 O ATOM 9152 N PHE C 165 23.342 45.545 −19.727 1.00 63.98 N ATOM 9153 CA PHE C 165 22.607 46.329 −18.718 1.00 65.81 C ATOM 9154 CB PHE C 165 23.577 46.968 −17.740 1.00 62.64 C ATOM 9155 CG PHE C 165 24.597 47.886 −18.384 1.00 61.31 C ATOM 9156 CD1 PHE C 165 24.231 49.142 −18.869 1.00 59.47 C ATOM 9157 CE1 PHE C 165 25.177 49.978 −19.418 1.00 59.69 C ATOM 9158 CZ PHE C 165 26.508 49.573 −19.501 1.00 60.18 C ATOM 9159 CE2 PHE C 165 26.884 48.331 −19.058 1.00 57.28 C ATOM 9160 CD2 PHE C 165 25.936 47.496 −18.493 1.00 59.20 C ATOM 9161 C PHE C 165 21.648 47.406 −19.276 1.00 67.98 C ATOM 9162 O PHE C 165 21.756 47.807 −20.444 1.00 63.36 O ATOM 9163 N LYS C 166 20.720 47.814 −18.400 1.00 69.94 N ATOM 9164 CA LYS C 166 19.896 49.006 −18.511 1.00 76.42 C ATOM 9165 CB LYS C 166 18.489 48.705 −17.973 1.00 87.18 C ATOM 9166 CG LYS C 166 17.414 49.785 −18.216 1.00 98.84 C ATOM 9167 CD LYS C 166 16.282 49.858 −17.154 1.00 101.35 C ATOM 9168 CE LYS C 166 15.641 48.515 −16.770 1.00 99.88 C ATOM 9169 NZ LYS C 166 14.816 47.928 −17.856 1.00 100.81 N ATOM 9170 C LYS C 166 20.527 50.075 −17.622 1.00 78.47 C ATOM 9171 O LYS C 166 20.930 49.786 −16.474 1.00 79.83 O ATOM 9172 N VAL C 167 20.602 51.309 −18.119 1.00 78.42 N ATOM 9173 CA VAL C 167 21.108 52.420 −17.294 1.00 78.77 C ATOM 9174 CB VAL C 167 21.686 53.591 −18.113 1.00 78.06 C ATOM 9175 CG1 VAL C 167 22.277 54.665 −17.195 1.00 78.23 C ATOM 9176 CG2 VAL C 167 22.755 53.098 −19.065 1.00 76.98 C ATOM 9177 C VAL C 167 19.977 52.942 −16.425 1.00 79.54 C ATOM 9178 O VAL C 167 18.816 52.931 −16.817 1.00 77.62 O ATOM 9179 N LEU C 168 20.338 53.364 −15.225 1.00 83.97 N ATOM 9180 CA LEU C 168 19.400 53.925 −14.266 1.00 87.72 C ATOM 9181 CB LEU C 168 19.394 53.102 −12.966 1.00 85.09 C ATOM 9182 CG LEU C 168 18.973 51.634 −13.200 1.00 84.45 C ATOM 9183 CD1 LEU C 168 19.020 50.774 −11.925 1.00 80.63 C ATOM 9184 CD2 LEU C 168 17.593 51.610 −13.881 1.00 82.38 C ATOM 9185 C LEU C 168 19.813 55.345 −14.021 1.00 90.59 C ATOM 9186 O LEU C 168 19.061 56.264 −14.312 1.00 105.38 O ATOM 9187 N GLU C 169 21.027 55.524 −13.525 1.00 90.17 N ATOM 9188 CA GLU C 169 21.543 56.834 −13.176 1.00 90.59 C ATOM 9189 CB GLU C 169 21.586 56.964 −11.623 1.00 92.97 C ATOM 9190 CG GLU C 169 21.120 58.294 −11.002 1.00 89.66 C ATOM 9191 CD GLU C 169 20.007 58.136 −9.963 1.00 89.91 C ATOM 9192 OE1 GLU C 169 19.156 59.081 −9.897 1.00 84.16 O ATOM 9193 OE2 GLU C 169 19.980 57.083 −9.238 1.00 79.23 O ATOM 9194 C GLU C 169 22.927 56.982 −13.832 1.00 90.59 C ATOM 9195 O GLU C 169 23.509 56.004 −14.304 1.00 87.52 O ATOM 9196 N LEU C 170 23.414 58.225 −13.849 1.00 93.84 N ATOM 9197 CA LEU C 170 24.696 58.640 −14.422 1.00 90.35 C ATOM 9198 CB LEU C 170 24.570 58.844 −15.958 1.00 86.96 C ATOM 9199 CG LEU C 170 25.054 57.750 −16.924 1.00 86.04 C ATOM 9200 CD1 LEU C 170 24.479 57.859 −18.331 1.00 81.87 C ATOM 9201 CD2 LEU C 170 26.569 57.782 −16.994 1.00 89.10 C ATOM 9202 C LEU C 170 25.125 59.946 −13.708 1.00 94.89 C ATOM 9203 O LEU C 170 25.052 61.043 −14.292 1.00 93.48 O ATOM 9204 N ARG C 171 25.691 59.816 −12.528 1.00 102.22 N ATOM 9205 CA ARG C 171 26.205 60.989 −11.887 1.00 104.95 C ATOM 9206 CB ARG C 171 26.270 60.772 −10.388 1.00 114.66 C ATOM 9207 CG ARG C 171 24.939 60.371 −9.779 1.00 124.54 C ATOM 9208 CD ARG C 171 24.665 58.889 −9.963 1.00 126.90 C ATOM 9209 NE ARG C 171 25.695 58.094 −9.313 1.00 123.11 N ATOM 9210 CZ ARG C 171 25.474 56.932 −8.722 1.00 109.16 C ATOM 9211 NH1 ARG C 171 26.472 56.292 −8.150 1.00 103.13 N ATOM 9212 NH2 ARG C 171 24.259 56.423 −8.690 1.00 107.17 N ATOM 9213 C ARG C 171 27.604 61.072 −12.438 1.00 90.62 C ATOM 9214 O ARG C 171 28.397 60.196 −12.197 1.00 84.96 O ATOM 9215 N THR C 172 27.917 62.119 −13.180 1.00 82.44 N ATOM 9216 CA THR C 172 29.258 62.251 −13.717 1.00 79.72 C ATOM 9217 CB THR C 172 29.367 63.186 −14.932 1.00 76.30 C ATOM 9218 OG1 THR C 172 29.868 64.459 −14.541 1.00 68.90 O ATOM 9219 CG2 THR C 172 28.035 63.336 −15.613 1.00 72.88 C ATOM 9220 C THR C 172 30.056 62.691 −12.516 1.00 80.38 C ATOM 9221 O THR C 172 29.481 62.918 −11.473 1.00 79.14 O ATOM 9222 N GLN C 173 31.369 62.762 −12.622 1.00 83.55 N ATOM 9223 CA GLN C 173 32.172 63.122 −11.467 1.00 86.74 C ATOM 9224 CB GLN C 173 32.961 61.914 −10.979 1.00 80.37 C ATOM 9225 C GLN C 173 33.095 64.295 −11.706 1.00 91.99 C ATOM 9226 O GLN C 173 33.401 64.634 −12.839 1.00 90.81 O ATOM 9227 N SER C 174 33.545 64.892 −10.611 1.00 95.35 N ATOM 9228 CA SER C 174 34.408 66.056 −10.633 1.00 93.15 C ATOM 9229 CB SER C 174 34.778 66.430 −9.219 1.00 89.95 C ATOM 9230 OG SER C 174 34.852 65.262 −8.431 1.00 89.80 O ATOM 9231 C SER C 174 35.643 65.704 −11.408 1.00 96.09 C ATOM 9232 O SER C 174 36.193 66.532 −12.113 1.00 95.70 O ATOM 9233 N ASP C 175 36.076 64.464 −11.282 1.00 100.02 N ATOM 9234 CA ASP C 175 37.231 64.000 −12.020 1.00 96.90 C ATOM 9235 CB ASP C 175 37.568 62.566 −11.647 1.00 87.05 C ATOM 9236 C ASP C 175 36.883 64.092 −13.502 1.00 105.36 C ATOM 9237 O ASP C 175 37.771 64.104 −14.346 1.00 101.69 O ATOM 9238 N GLY C 176 35.586 64.155 −13.809 1.00 115.12 N ATOM 9239 CA GLY C 176 35.100 64.249 −15.174 1.00 116.57 C ATOM 9240 C GLY C 176 34.712 62.921 −15.776 1.00 116.61 C ATOM 9241 O GLY C 176 34.425 62.811 −16.962 1.00 116.04 O ATOM 9242 N ILE C 177 34.705 61.904 −14.935 1.00 111.48 N ATOM 9243 CA ILE C 177 34.372 60.563 −15.334 1.00 101.15 C ATOM 9244 CB ILE C 177 35.338 59.608 −14.629 1.00 104.07 C ATOM 9245 CG1 ILE C 177 36.732 59.778 −15.207 1.00 104.44 C ATOM 9246 CD1 ILE C 177 36.808 59.453 −16.672 1.00 102.58 C ATOM 9247 CG2 ILE C 177 34.910 58.166 −14.772 1.00 104.14 C ATOM 9248 C ILE C 177 32.961 60.237 −14.899 1.00 91.61 C ATOM 9249 O ILE C 177 32.634 60.389 −13.746 1.00 87.75 O ATOM 9250 N GLN C 178 32.131 59.783 −15.827 1.00 84.40 N ATOM 9251 CA GLN C 178 30.762 59.419 −15.517 1.00 80.73 C ATOM 9252 CB GLN C 178 29.947 59.230 −16.776 1.00 81.14 C ATOM 9253 CG GLN C 178 29.165 60.446 −17.193 1.00 81.56 C ATOM 9254 CD GLN C 178 28.627 60.298 −18.582 1.00 86.61 C ATOM 9255 OE1 GLN C 178 29.296 59.770 −19.454 1.00 85.65 O ATOM 9256 NE2 GLN C 178 27.416 60.762 −18.800 1.00 91.90 N ATOM 9257 C GLN C 178 30.801 58.142 −14.739 1.00 77.00 C ATOM 9258 O GLN C 178 31.757 57.418 −14.826 1.00 75.25 O ATOM 9259 N GLN C 179 29.767 57.874 −13.967 1.00 72.36 N ATOM 9260 CA GLN C 179 29.714 56.682 −13.122 1.00 68.92 C ATOM 9261 CB GLN C 179 30.129 57.036 −11.680 1.00 70.45 C ATOM 9262 CG GLN C 179 31.627 56.948 −11.352 1.00 70.89 C ATOM 9263 CD GLN C 179 32.061 55.584 −10.812 1.00 74.90 C ATOM 9264 OE1 GLN C 179 31.233 54.753 −10.433 1.00 83.89 O ATOM 9265 NE2 GLN C 179 33.367 55.344 −10.780 1.00 74.58 N ATOM 9266 C GLN C 179 28.280 56.172 −13.181 1.00 67.27 C ATOM 9267 O GLN C 179 27.390 56.722 −12.541 1.00 67.54 O ATOM 9268 N ALA C 180 28.047 55.134 −13.957 1.00 69.58 N ATOM 9269 CA ALA C 180 26.708 54.618 −14.141 1.00 69.21 C ATOM 9270 CB ALA C 180 26.557 54.151 −15.562 1.00 68.11 C ATOM 9271 C ALA C 180 26.247 53.533 −13.216 1.00 67.93 C ATOM 9272 O ALA C 180 26.954 52.588 −12.969 1.00 59.81 O ATOM 9273 N LYS C 181 25.029 53.678 −12.722 1.00 76.13 N ATOM 9274 CA LYS C 181 24.426 52.697 −11.853 1.00 82.04 C ATOM 9275 CB LYS C 181 23.498 53.360 −10.852 1.00 92.83 C ATOM 9276 CG LYS C 181 22.471 52.406 −10.279 1.00 104.69 C ATOM 9277 CD LYS C 181 21.529 53.055 −9.287 1.00 110.86 C ATOM 9278 CE LYS C 181 21.874 52.664 −7.861 1.00 114.65 C ATOM 9279 NZ LYS C 181 20.754 52.930 −6.913 1.00 117.12 N ATOM 9280 C LYS C 181 23.635 51.901 −12.833 1.00 75.11 C ATOM 9281 O LYS C 181 22.873 52.459 −13.591 1.00 76.98 O ATOM 9282 N VAL C 182 23.810 50.593 −12.824 1.00 69.65 N ATOM 9283 CA VAL C 182 23.164 49.757 −13.806 1.00 68.82 C ATOM 9284 CB VAL C 182 24.248 49.190 −14.715 1.00 66.57 C ATOM 9285 CG1 VAL C 182 23.631 48.429 −15.864 1.00 68.31 C ATOM 9286 CG2 VAL C 182 25.116 50.306 −15.240 1.00 63.14 C ATOM 9287 C VAL C 182 22.385 48.573 −13.308 1.00 65.19 C ATOM 9288 O VAL C 182 22.609 48.097 −12.220 1.00 60.62 O ATOM 9289 N GLN C 183 21.467 48.104 −14.143 1.00 64.33 N ATOM 9290 CA GLN C 183 20.658 46.941 −13.836 1.00 67.80 C ATOM 9291 CB GLN C 183 19.201 47.237 −14.109 1.00 71.87 C ATOM 9292 CG GLN C 183 18.294 47.044 −12.916 1.00 75.76 C ATOM 9293 CD GLN C 183 17.687 45.675 −12.839 1.00 77.37 C ATOM 9294 OE1 GLN C 183 16.929 45.280 −13.706 1.00 82.46 O ATOM 9295 NE2 GLN C 183 17.997 44.952 −11.780 1.00 77.58 N ATOM 9296 C GLN C 183 21.141 45.870 −14.779 1.00 63.22 C ATOM 9297 O GLN C 183 21.143 46.053 −15.972 1.00 59.70 O ATOM 9298 N ILE C 184 21.557 44.749 −14.234 1.00 59.68 N ATOM 9299 CA ILE C 184 22.107 43.658 −15.024 1.00 63.19 C ATOM 9300 CB ILE C 184 22.986 42.708 −14.192 1.00 65.49 C ATOM 9301 CG1 ILE C 184 24.196 43.449 −13.616 1.00 65.36 C ATOM 9302 CD1 ILE C 184 25.284 43.758 −14.635 1.00 64.74 C ATOM 9303 CG2 ILE C 184 23.469 41.542 −15.051 1.00 65.81 C ATOM 9304 C ILE C 184 20.966 42.888 −15.655 1.00 62.10 C ATOM 9305 O ILE C 184 20.066 42.420 −14.971 1.00 59.03 O ATOM 9306 N LEU C 185 20.988 42.769 −16.971 1.00 62.51 N ATOM 9307 CA LEU C 185 19.845 42.186 −17.619 1.00 63.44 C ATOM 9308 CB LEU C 185 19.706 42.649 −19.047 1.00 65.05 C ATOM 9309 CG LEU C 185 19.625 44.144 −19.228 1.00 66.96 C ATOM 9310 CD1 LEU C 185 19.509 44.446 −20.711 1.00 68.46 C ATOM 9311 CD2 LEU C 185 18.473 44.735 −18.441 1.00 66.93 C ATOM 9312 C LEU C 185 20.017 40.698 −17.611 1.00 64.24 C ATOM 9313 O LEU C 185 21.064 40.213 −18.054 1.00 62.74 O ATOM 9314 N PRO C 186 18.971 39.970 −17.179 1.00 64.67 N ATOM 9315 CA PRO C 186 19.008 38.536 −17.215 1.00 67.45 C ATOM 9316 CB PRO C 186 17.658 38.162 −16.614 1.00 66.72 C ATOM 9317 CG PRO C 186 16.738 39.224 −17.097 1.00 63.83 C ATOM 9318 CD PRO C 186 17.577 40.462 −17.142 1.00 65.84 C ATOM 9319 C PRO C 186 19.093 38.041 −18.661 1.00 74.85 C ATOM 9320 O PRO C 186 18.638 38.719 −19.580 1.00 76.23 O ATOM 9321 N GLU C 187 19.665 36.870 −18.874 1.00 85.45 N ATOM 9322 CA GLU C 187 19.755 36.349 −20.218 1.00 85.27 C ATOM 9323 CB GLU C 187 21.110 35.707 −20.401 1.00 87.33 C ATOM 9324 CG GLU C 187 21.543 35.570 −21.839 1.00 93.16 C ATOM 9325 CD GLU C 187 21.770 36.898 −22.509 1.00 96.14 C ATOM 9326 OE1 GLU C 187 21.998 37.896 −21.815 1.00 78.72 O ATOM 9327 OE2 GLU C 187 21.716 36.937 −23.744 1.00 90.47 O ATOM 9328 C GLU C 187 18.686 35.302 −20.314 1.00 79.58 C ATOM 9329 O GLU C 187 18.811 34.259 −19.733 1.00 79.52 O ATOM 9330 N CYS C 188 17.638 35.566 −21.072 1.00 80.23 N ATOM 9331 CA CYS C 188 16.527 34.633 −21.173 1.00 86.54 C ATOM 9332 CB CYS C 188 15.388 35.296 −21.937 1.00 94.54 C ATOM 9333 SG CYS C 188 14.202 34.199 −22.732 1.00 102.98 S ATOM 9334 C CYS C 188 16.810 33.278 −21.774 1.00 80.44 C ATOM 9335 O CYS C 188 17.408 33.165 −22.821 1.00 69.36 O ATOM 9336 N VAL C 189 16.310 32.256 −21.095 1.00 79.57 N ATOM 9337 CA VAL C 189 16.448 30.871 −21.508 1.00 88.89 C ATOM 9338 CB VAL C 189 17.341 30.082 −20.570 1.00 91.49 C ATOM 9339 CG1 VAL C 189 18.781 30.199 −21.000 1.00 90.30 C ATOM 9340 CG2 VAL C 189 17.150 30.554 −19.145 1.00 101.41 C ATOM 9341 C VAL C 189 15.091 30.212 −21.498 1.00 83.67 C ATOM 9342 O VAL C 189 14.279 30.501 −20.651 1.00 87.56 O ATOM 9343 N LEU C 190 14.849 29.333 −22.454 1.00 76.66 N ATOM 9344 CA LEU C 190 13.583 28.654 −22.563 1.00 68.93 C ATOM 9345 CB LEU C 190 12.831 29.150 −23.776 1.00 65.37 C ATOM 9346 CG LEU C 190 12.458 30.604 −23.882 1.00 67.91 C ATOM 9347 CD1 LEU C 190 11.413 30.744 −24.953 1.00 69.80 C ATOM 9348 CD2 LEU C 190 11.886 31.013 −22.559 1.00 74.25 C ATOM 9349 C LEU C 190 13.883 27.219 −22.794 1.00 69.01 C ATOM 9350 O LEU C 190 14.932 26.901 −23.301 1.00 73.65 O ATOM 9351 N PRO C 191 12.978 26.334 −22.430 1.00 67.23 N ATOM 9352 CA PRO C 191 13.259 24.919 −22.670 1.00 73.25 C ATOM 9353 CB PRO C 191 12.361 24.214 −21.644 1.00 75.04 C ATOM 9354 CG PRO C 191 11.492 25.288 −21.020 1.00 69.02 C ATOM 9355 CD PRO C 191 11.649 26.524 −21.835 1.00 63.70 C ATOM 9356 C PRO C 191 12.948 24.475 −24.122 1.00 71.95 C ATOM 9357 O PRO C 191 12.495 25.284 −24.943 1.00 66.68 O ATOM 9358 N SER C 192 13.164 23.210 −24.402 1.00 70.61 N ATOM 9359 CA SER C 192 12.933 22.702 −25.713 1.00 72.19 C ATOM 9360 CB SER C 192 13.241 21.227 −25.779 1.00 78.74 C ATOM 9361 OG SER C 192 12.690 20.673 −26.947 1.00 75.63 O ATOM 9362 C SER C 192 11.495 22.886 −25.951 1.00 67.77 C ATOM 9363 O SER C 192 10.714 22.893 −25.041 1.00 66.54 O ATOM 9364 N THR C 193 11.159 23.058 −27.205 1.00 71.70 N ATOM 9365 CA THR C 193 9.811 23.275 −27.618 1.00 71.97 C ATOM 9366 CB THR C 193 9.790 23.477 −29.123 1.00 76.64 C ATOM 9367 OG1 THR C 193 11.032 23.031 −29.653 1.00 81.84 O ATOM 9368 CG2 THR C 193 9.721 24.903 −29.430 1.00 76.76 C ATOM 9369 C THR C 193 8.998 22.081 −27.236 1.00 71.40 C ATOM 9370 O THR C 193 7.863 22.198 −26.827 1.00 71.30 O ATOM 9371 N MET C 194 9.595 20.918 −27.383 1.00 71.27 N ATOM 9372 CA MET C 194 8.950 19.655 −27.078 1.00 74.36 C ATOM 9373 CB MET C 194 9.744 18.537 −27.718 1.00 76.39 C ATOM 9374 CG MET C 194 9.705 18.524 −29.221 1.00 73.67 C ATOM 9375 SD MET C 194 8.043 18.286 −29.784 1.00 73.52 S ATOM 9376 CE MET C 194 7.478 19.955 −29.760 1.00 67.77 C ATOM 9377 C MET C 194 8.776 19.289 −25.623 1.00 74.57 C ATOM 9378 O MET C 194 8.030 18.398 −25.298 1.00 73.00 O ATOM 9379 N SER C 195 9.460 19.971 −24.738 1.00 84.82 N ATOM 9380 CA SER C 195 9.442 19.611 −23.340 1.00 86.80 C ATOM 9381 CB SER C 195 10.310 20.593 −22.597 1.00 87.32 C ATOM 9382 OG SER C 195 9.821 21.892 −22.817 1.00 86.43 O ATOM 9383 C SER C 195 8.101 19.594 −22.662 1.00 82.67 C ATOM 9384 O SER C 195 7.826 18.689 −21.884 1.00 74.84 O ATOM 9385 N ALA C 196 7.276 20.588 −22.916 1.00 82.46 N ATOM 9386 CA ALA C 196 5.992 20.607 −22.277 1.00 84.89 C ATOM 9387 CB ALA C 196 5.311 21.908 −22.617 1.00 86.62 C ATOM 9388 C ALA C 196 5.127 19.462 −22.734 1.00 79.43 C ATOM 9389 O ALA C 196 4.582 18.723 −21.953 1.00 83.81 O ATOM 9390 N VAL C 197 5.039 19.315 −24.031 1.00 71.74 N ATOM 9391 CA VAL C 197 4.212 18.327 −24.667 1.00 69.68 C ATOM 9392 CB VAL C 197 4.062 18.666 −26.139 1.00 70.91 C ATOM 9393 CG1 VAL C 197 5.351 18.392 −26.850 1.00 67.53 C ATOM 9394 CG2 VAL C 197 2.963 17.843 −26.748 1.00 78.97 C ATOM 9395 C VAL C 197 4.573 16.872 −24.572 1.00 72.72 C ATOM 9396 O VAL C 197 3.726 16.011 −24.497 1.00 70.74 O ATOM 9397 N GLN C 198 5.855 16.608 −24.576 1.00 75.02 N ATOM 9398 CA GLN C 198 6.382 15.278 −24.696 1.00 77.31 C ATOM 9399 CB GLN C 198 7.874 15.386 −24.383 1.00 85.63 C ATOM 9400 CG GLN C 198 8.651 14.089 −24.366 1.00 90.98 C ATOM 9401 CD GLN C 198 9.561 13.970 −25.545 1.00 97.44 C ATOM 9402 OE1 GLN C 198 9.922 14.961 −26.148 1.00 109.04 O ATOM 9403 NE2 GLN C 198 9.948 12.757 −25.874 1.00 103.85 N ATOM 9404 C GLN C 198 5.852 14.145 −23.861 1.00 73.53 C ATOM 9405 O GLN C 198 5.717 14.231 −22.666 1.00 72.57 O ATOM 9406 N LEU C 199 5.577 13.057 −24.569 1.00 74.77 N ATOM 9407 CA LEU C 199 5.171 11.768 −23.981 1.00 72.13 C ATOM 9408 CB LEU C 199 4.935 10.693 −25.066 1.00 71.13 C ATOM 9409 CG LEU C 199 3.524 10.403 −25.594 1.00 74.69 C ATOM 9410 CD1 LEU C 199 2.755 11.662 −25.892 1.00 70.25 C ATOM 9411 CD2 LEU C 199 3.564 9.544 −26.857 1.00 81.50 C ATOM 9412 C LEU C 199 6.266 11.294 −23.031 1.00 67.51 C ATOM 9413 O LEU C 199 7.436 11.283 −23.399 1.00 67.17 O ATOM 9414 N GLU C 200 5.868 10.840 −21.851 1.00 65.18 N ATOM 9415 CA GLU C 200 6.805 10.465 −20.786 1.00 67.88 C ATOM 9416 CB GLU C 200 6.182 10.597 −19.381 1.00 74.15 C ATOM 9417 CG GLU C 200 5.040 11.611 −19.247 1.00 85.96 C ATOM 9418 CD GLU C 200 3.692 11.020 −19.675 1.00 97.34 C ATOM 9419 OE1 GLU C 200 3.140 11.392 −20.755 1.00 89.91 O ATOM 9420 OE2 GLU C 200 3.213 10.124 −18.954 1.00 105.42 O ATOM 9421 C GLU C 200 7.361 9.040 −21.021 1.00 66.52 C ATOM 9422 O GLU C 200 8.434 8.684 −20.529 1.00 66.68 O ATOM 9423 N SER C 201 6.648 8.226 −21.792 1.00 70.35 N ATOM 9424 CA SER C 201 7.200 6.952 −22.269 1.00 73.46 C ATOM 9425 CB SER C 201 6.135 6.101 −22.951 1.00 68.72 C ATOM 9426 OG SER C 201 5.564 6.815 −24.021 1.00 72.49 O ATOM 9427 C SER C 201 8.360 7.186 −23.224 1.00 73.72 C ATOM 9428 O SER C 201 9.265 6.348 −23.298 1.00 78.74 O ATOM 9429 N LEU C 202 8.322 8.325 −23.928 1.00 76.29 N ATOM 9430 CA LEU C 202 9.402 8.785 −24.825 1.00 80.07 C ATOM 9431 CB LEU C 202 8.793 9.425 −26.085 1.00 75.90 C ATOM 9432 CG LEU C 202 7.690 8.637 −26.808 1.00 81.48 C ATOM 9433 CD1 LEU C 202 7.230 9.383 −28.048 1.00 85.86 C ATOM 9434 CD2 LEU C 202 8.127 7.229 −27.182 1.00 82.90 C ATOM 9435 C LEU C 202 10.440 9.749 −24.188 1.00 81.31 C ATOM 9436 O LEU C 202 11.257 10.329 −24.903 1.00 83.41 O ATOM 9437 N ASN C 203 10.417 9.913 −22.863 1.00 84.76 N ATOM 9438 CA ASN C 203 11.482 10.627 −22.142 1.00 86.99 C ATOM 9439 CB ASN C 203 11.173 10.772 −20.637 1.00 85.09 C ATOM 9440 CG ASN C 203 10.159 11.869 −20.322 1.00 84.10 C ATOM 9441 OD1 ASN C 203 9.400 11.757 −19.355 1.00 79.43 O ATOM 9442 ND2 ASN C 203 10.149 12.932 −21.113 1.00 84.89 N ATOM 9443 C ASN C 203 12.799 9.883 −22.275 1.00 93.49 C ATOM 9444 O ASN C 203 13.841 10.488 −22.538 1.00 94.28 O ATOM 9445 N LYS C 204 12.729 8.563 −22.116 1.00 100.28 N ATOM 9446 CA LYS C 204 13.904 7.695 −22.109 1.00 101.29 C ATOM 9447 CB LYS C 204 13.484 6.237 −21.838 1.00 108.65 C ATOM 9448 CG LYS C 204 12.759 5.982 −20.510 1.00 117.30 C ATOM 9449 CD LYS C 204 12.212 4.549 −20.409 1.00 121.13 C ATOM 9450 CE LYS C 204 10.941 4.456 −19.566 1.00 117.74 C ATOM 9451 NZ LYS C 204 9.740 5.005 −20.269 1.00 110.50 N ATOM 9452 C LYS C 204 14.745 7.788 −23.406 1.00 101.61 C ATOM 9453 O LYS C 204 15.900 7.378 −23.406 1.00 106.00 O ATOM 9454 N CYS C 205 14.182 8.337 −24.489 1.00 103.49 N ATOM 9455 CA CYS C 205 14.858 8.420 −25.797 1.00 102.42 C ATOM 9456 CB CYS C 205 13.922 7.849 −26.861 1.00 96.36 C ATOM 9457 SG CYS C 205 13.019 6.425 −26.233 1.00 91.08 S ATOM 9458 C CYS C 205 15.308 9.824 −26.236 1.00 106.63 C ATOM 9459 O CYS C 205 15.621 10.017 −27.418 1.00 108.45 O ATOM 9460 N GLN C 206 15.362 10.784 −25.306 1.00 109.59 N ATOM 9461 CA GLN C 206 15.728 12.177 −25.634 1.00 112.01 C ATOM 9462 CB GLN C 206 15.116 13.173 −24.627 1.00 104.10 C ATOM 9463 CG GLN C 206 13.594 13.256 −24.651 1.00 102.80 C ATOM 9464 CD GLN C 206 13.014 13.371 −26.059 1.00 106.45 C ATOM 9465 OE1 GLN C 206 12.288 12.487 −26.513 1.00 106.70 O ATOM 9466 NE2 GLN C 206 13.357 14.446 −26.766 1.00 102.38 N ATOM 9467 C GLN C 206 17.240 12.421 −25.786 1.00 120.87 C ATOM 9468 O GLN C 206 17.645 13.327 −26.519 1.00 138.36 O ATOM 9469 N ILE C 207 18.072 11.636 −25.108 1.00 124.67 N ATOM 9470 CA ILE C 207 19.516 11.692 −25.340 1.00 128.28 C ATOM 9471 CB ILE C 207 20.326 11.301 −24.080 1.00 124.92 C ATOM 9472 CG1 ILE C 207 19.985 12.270 −22.937 1.00 113.64 C ATOM 9473 CD1 ILE C 207 20.962 12.301 −21.782 1.00 111.00 C ATOM 9474 CG2 ILE C 207 21.826 11.313 −24.382 1.00 133.59 C ATOM 9475 C ILE C 207 19.840 10.762 −26.499 1.00 126.20 C ATOM 9476 O ILE C 207 19.370 9.628 −26.524 1.00 134.58 O ATOM 9477 N PHE C 208 20.638 11.247 −27.448 1.00 125.95 N ATOM 9478 CA PHE C 208 21.101 10.434 −28.574 1.00 133.91 C ATOM 9479 CB PHE C 208 20.735 11.100 −29.902 1.00 133.81 C ATOM 9480 CG PHE C 208 19.375 11.733 −29.917 1.00 132.73 C ATOM 9481 CD1 PHE C 208 18.225 10.942 −29.927 1.00 143.33 C ATOM 9482 CE1 PHE C 208 16.965 11.524 −29.952 1.00 145.03 C ATOM 9483 CZ PHE C 208 16.844 12.910 −29.974 1.00 140.18 C ATOM 9484 CE2 PHE C 208 17.983 13.706 −29.971 1.00 133.55 C ATOM 9485 CD2 PHE C 208 19.239 13.119 −29.945 1.00 124.20 C ATOM 9486 C PHE C 208 22.624 10.251 −28.526 1.00 143.81 C ATOM 9487 O PHE C 208 23.313 10.971 −27.794 1.00 149.14 O ATOM 9488 N PRO C 209 23.154 9.284 −29.305 1.00 140.46 N ATOM 9489 CA PRO C 209 24.569 9.286 −29.713 1.00 145.75 C ATOM 9490 CB PRO C 209 24.747 7.912 −30.380 1.00 139.18 C ATOM 9491 CG PRO C 209 23.629 7.079 −29.859 1.00 131.14 C ATOM 9492 CD PRO C 209 22.490 8.026 −29.671 1.00 125.69 C ATOM 9493 C PRO C 209 24.868 10.439 −30.702 1.00 148.85 C ATOM 9494 O PRO C 209 23.964 10.874 −31.423 1.00 146.83 O ATOM 9495 N SER C 210 26.116 10.914 −30.741 1.00 148.30 N ATOM 9496 CA SER C 210 26.464 12.167 −31.455 1.00 156.12 C ATOM 9497 CB SER C 210 27.522 12.981 −30.677 1.00 157.41 C ATOM 9498 OG SER C 210 27.953 12.316 −29.501 1.00 152.88 O ATOM 9499 C SER C 210 26.861 12.033 −32.944 1.00 154.68 C ATOM 9500 O SER C 210 27.235 10.955 −33.421 1.00 141.26 O ATOM 9501 N LYS C 211 26.773 13.175 −33.634 1.00 159.06 N ATOM 9502 CA LYS C 211 26.839 13.288 −35.116 1.00 165.33 C ATOM 9503 CB LYS C 211 26.485 14.737 −35.583 1.00 156.94 C ATOM 9504 CG LYS C 211 27.141 15.927 −34.849 1.00 151.51 C ATOM 9505 CD LYS C 211 26.128 16.997 −34.388 1.00 142.43 C ATOM 9506 CE LYS C 211 26.333 17.455 −32.937 1.00 128.41 C ATOM 9507 NZ LYS C 211 25.178 18.221 −32.369 1.00 109.66 N ATOM 9508 C LYS C 211 28.140 12.784 −35.806 1.00 174.81 C ATOM 9509 O LYS C 211 29.216 13.335 −35.552 1.00 174.97 O ATOM 9510 N PRO C 212 28.038 11.741 −36.681 1.00 183.91 N ATOM 9511 CA PRO C 212 29.173 11.306 −37.526 1.00 189.11 C ATOM 9512 CB PRO C 212 28.583 10.130 −38.327 1.00 184.72 C ATOM 9513 CG PRO C 212 27.523 9.579 −37.443 1.00 174.62 C ATOM 9514 CD PRO C 212 26.914 10.784 −36.783 1.00 177.41 C ATOM 9515 C PRO C 212 29.737 12.402 −38.463 1.00 187.12 C ATOM 9516 O PRO C 212 29.116 12.740 −39.481 1.00 189.91 O ATOM 9517 N VAL C 213 30.916 12.926 −38.108 1.00 173.75 N ATOM 9518 CA VAL C 213 31.501 14.110 −38.769 1.00 156.85 C ATOM 9519 CB VAL C 213 32.713 14.696 −37.987 1.00 155.53 C ATOM 9520 CG1 VAL C 213 32.329 15.054 −36.549 1.00 147.29 C ATOM 9521 CG2 VAL C 213 33.918 13.752 −38.026 1.00 155.04 C ATOM 9522 C VAL C 213 31.923 13.841 −40.215 1.00 134.37 C ATOM 9523 O VAL C 213 32.141 14.777 −40.979 1.00 107.01 O ATOM 9524 N SER C 220 26.804 14.175 −43.186 1.00 134.21 N ATOM 9525 CA SER C 220 25.998 13.506 −42.182 1.00 134.51 C ATOM 9526 CB SER C 220 26.672 13.597 −40.825 1.00 129.00 C ATOM 9527 OG SER C 220 26.695 14.933 −40.378 1.00 118.01 O ATOM 9528 C SER C 220 24.625 14.138 −42.106 1.00 128.89 C ATOM 9529 O SER C 220 24.039 14.239 −41.048 1.00 121.53 O ATOM 9530 N TYR C 221 24.111 14.553 −43.244 1.00 126.86 N ATOM 9531 CA TYR C 221 22.813 15.176 −43.306 1.00 122.10 C ATOM 9532 CB TYR C 221 22.571 15.735 −44.709 1.00 133.46 C ATOM 9533 CG TYR C 221 21.411 15.185 −45.508 1.00 150.11 C ATOM 9534 CD1 TYR C 221 20.533 16.041 −46.142 1.00 157.98 C ATOM 9535 CE1 TYR C 221 19.477 15.567 −46.884 1.00 154.09 C ATOM 9536 CZ TYR C 221 19.287 14.222 −46.994 1.00 148.81 C ATOM 9537 OH TYR C 221 18.233 13.743 −47.735 1.00 136.82 O ATOM 9538 CE2 TYR C 221 20.145 13.347 −46.369 1.00 148.31 C ATOM 9539 CD2 TYR C 221 21.203 13.833 −45.636 1.00 151.42 C ATOM 9540 C TYR C 221 21.744 14.211 −42.859 1.00 122.62 C ATOM 9541 O TYR C 221 20.764 14.599 −42.259 1.00 112.00 O ATOM 9542 N LYS C 222 21.940 12.945 −43.169 1.00 132.11 N ATOM 9543 CA LYS C 222 20.983 11.914 −42.828 1.00 128.11 C ATOM 9544 CB LYS C 222 21.487 10.560 −43.294 1.00 140.52 C ATOM 9545 CG LYS C 222 22.816 10.147 −42.687 1.00 139.23 C ATOM 9546 CD LYS C 222 23.449 9.029 −43.497 1.00 135.67 C ATOM 9547 CE LYS C 222 23.784 9.485 −44.908 1.00 132.32 C ATOM 9548 NZ LYS C 222 24.959 10.396 −44.962 1.00 129.03 N ATOM 9549 C LYS C 222 20.817 11.900 −41.340 1.00 112.93 C ATOM 9550 O LYS C 222 19.745 11.657 −40.825 1.00 115.88 O ATOM 9551 N TRP C 223 21.898 12.161 −40.642 1.00 98.85 N ATOM 9552 CA TRP C 223 21.851 12.176 −39.209 1.00 89.83 C ATOM 9553 CB TRP C 223 23.214 12.563 −38.702 1.00 81.14 C ATOM 9554 CG TRP C 223 23.334 12.486 −37.278 1.00 79.13 C ATOM 9555 CD1 TRP C 223 23.798 11.450 −36.573 1.00 82.60 C ATOM 9556 NE1 TRP C 223 23.779 11.732 −35.246 1.00 85.50 N ATOM 9557 CE2 TRP C 223 23.291 12.993 −35.081 1.00 88.29 C ATOM 9558 CD2 TRP C 223 23.005 13.493 −36.346 1.00 88.13 C ATOM 9559 CE3 TRP C 223 22.498 14.776 −36.457 1.00 95.07 C ATOM 9560 CZ3 TRP C 223 22.299 15.500 −35.315 1.00 96.01 C ATOM 9561 CH2 TRP C 223 22.588 14.973 −34.074 1.00 89.61 C ATOM 9562 CZ2 TRP C 223 23.080 13.720 −33.935 1.00 88.64 C ATOM 9563 C TRP C 223 20.869 13.218 −38.739 1.00 90.39 C ATOM 9564 O TRP C 223 20.119 12.983 −37.823 1.00 97.71 O ATOM 9565 N TRP C 224 20.860 14.375 −39.369 1.00 84.48 N ATOM 9566 CA TRP C 224 19.956 15.429 −38.961 1.00 86.32 C ATOM 9567 CB TRP C 224 20.296 16.724 −39.674 1.00 90.45 C ATOM 9568 CG TRP C 224 21.480 17.338 −39.083 1.00 89.08 C ATOM 9569 CD1 TRP C 224 22.750 17.201 −39.492 1.00 87.42 C ATOM 9570 NE1 TRP C 224 23.588 17.892 −38.670 1.00 88.10 N ATOM 9571 CE2 TRP C 224 22.845 18.485 −37.691 1.00 89.37 C ATOM 9572 CD2 TRP C 224 21.516 18.149 −37.920 1.00 90.97 C ATOM 9573 CE3 TRP C 224 20.546 18.637 −37.056 1.00 92.16 C ATOM 9574 CZ3 TRP C 224 20.928 19.418 −36.021 1.00 94.21 C ATOM 9575 CH2 TRP C 224 22.253 19.735 −35.814 1.00 97.08 C ATOM 9576 CZ2 TRP C 224 23.229 19.280 −36.640 1.00 90.66 C ATOM 9577 C TRP C 224 18.500 15.067 −39.114 1.00 89.06 C ATOM 9578 O TRP C 224 17.676 15.478 −38.324 1.00 91.19 O ATOM 9579 N GLN C 225 18.188 14.296 −40.133 1.00 92.24 N ATOM 9580 CA GLN C 225 16.816 13.814 −40.391 1.00 92.08 C ATOM 9581 CB GLN C 225 16.692 13.076 −41.720 1.00 101.27 C ATOM 9582 CG GLN C 225 16.386 13.992 −42.885 1.00 116.12 C ATOM 9583 CD GLN C 225 16.729 13.334 −44.203 1.00 128.51 C ATOM 9584 OE1 GLN C 225 16.272 12.227 −44.478 1.00 127.93 O ATOM 9585 NE2 GLN C 225 17.558 13.992 −45.014 1.00 138.02 N ATOM 9586 C GLN C 225 16.339 12.896 −39.303 1.00 79.95 C ATOM 9587 O GLN C 225 15.186 12.995 −38.895 1.00 74.85 O ATOM 9588 N LYS C 226 17.212 11.985 −38.868 1.00 75.24 N ATOM 9589 CA LYS C 226 16.877 11.053 −37.791 1.00 76.95 C ATOM 9590 CB LYS C 226 17.902 9.906 −37.698 1.00 70.79 C ATOM 9591 C LYS C 226 16.719 11.824 −36.463 1.00 77.63 C ATOM 9592 O LYS C 226 15.798 11.545 −35.685 1.00 76.77 O ATOM 9593 N TYR C 227 17.601 12.801 −36.230 1.00 78.72 N ATOM 9594 CA TYR C 227 17.454 13.791 −35.139 1.00 76.58 C ATOM 9595 CB TYR C 227 18.576 14.841 −35.231 1.00 74.81 C ATOM 9596 CG TYR C 227 18.451 16.043 −34.306 1.00 73.65 C ATOM 9597 CD1 TYR C 227 17.654 17.147 −34.657 1.00 79.89 C ATOM 9598 CE1 TYR C 227 17.545 18.254 −33.821 1.00 78.09 C ATOM 9599 CZ TYR C 227 18.255 18.275 −32.627 1.00 73.27 C ATOM 9600 OH TYR C 227 18.143 19.369 −31.794 1.00 76.19 O ATOM 9601 CE2 TYR C 227 19.063 17.202 −32.271 1.00 67.31 C ATOM 9602 CD2 TYR C 227 19.160 16.101 −33.104 1.00 66.44 C ATOM 9603 C TYR C 227 16.092 14.487 −35.192 1.00 73.06 C ATOM 9604 O TYR C 227 15.370 14.559 −34.204 1.00 74.23 O ATOM 9605 N GLN C 228 15.758 15.015 −36.354 1.00 70.90 N ATOM 9606 CA GLN C 228 14.477 15.680 −36.530 1.00 71.11 C ATOM 9607 CB GLN C 228 14.340 16.240 −37.944 1.00 66.53 C ATOM 9608 CG GLN C 228 13.689 17.603 −37.974 1.00 67.42 C ATOM 9609 CD GLN C 228 12.966 17.877 −39.266 1.00 70.52 C ATOM 9610 OE1 GLN C 228 12.853 19.026 −39.703 1.00 61.74 O ATOM 9611 NE2 GLN C 228 12.457 16.817 −39.887 1.00 76.01 N ATOM 9612 C GLN C 228 13.299 14.739 −36.224 1.00 74.75 C ATOM 9613 O GLN C 228 12.377 15.134 −35.533 1.00 83.32 O ATOM 9614 N LYS C 229 13.330 13.507 −36.734 1.00 79.81 N ATOM 9615 CA LYS C 229 12.274 12.522 −36.434 1.00 78.02 C ATOM 9616 CB LYS C 229 12.405 11.238 −37.293 1.00 70.09 C ATOM 9617 C LYS C 229 12.240 12.188 −34.924 1.00 73.15 C ATOM 9618 O LYS C 229 11.156 12.114 −34.350 1.00 76.30 O ATOM 9619 N ARG C 230 13.401 12.020 −34.281 1.00 65.27 N ATOM 9620 CA ARG C 230 13.432 11.567 −32.877 1.00 67.48 C ATOM 9621 CB ARG C 230 14.804 10.969 −32.471 1.00 56.97 C ATOM 9622 C ARG C 230 12.985 12.695 −31.935 1.00 74.38 C ATOM 9623 O ARG C 230 12.003 12.538 −31.208 1.00 82.97 O ATOM 9624 N LYS C 231 13.675 13.839 −31.999 1.00 80.18 N ATOM 9625 CA LYS C 231 13.418 14.995 −31.132 1.00 70.98 C ATOM 9626 CB LYS C 231 14.380 16.128 −31.450 1.00 74.74 C ATOM 9627 CG LYS C 231 14.129 17.393 −30.636 1.00 78.93 C ATOM 9628 CD LYS C 231 15.402 18.214 −30.466 1.00 84.48 C ATOM 9629 CE LYS C 231 15.348 19.102 −29.232 1.00 89.91 C ATOM 9630 NZ LYS C 231 16.701 19.194 −28.625 1.00 92.05 N ATOM 9631 C LYS C 231 12.010 15.540 −31.233 1.00 66.38 C ATOM 9632 O LYS C 231 11.425 15.878 −30.219 1.00 77.22 O ATOM 9633 N PHE C 232 11.466 15.628 −32.436 1.00 56.58 N ATOM 9634 CA PHE C 232 10.144 16.214 −32.619 1.00 58.23 C ATOM 9635 CB PHE C 232 10.233 17.262 −33.712 1.00 61.95 C ATOM 9636 CG PHE C 232 11.264 18.295 −33.423 1.00 71.01 C ATOM 9637 CD1 PHE C 232 11.034 19.252 −32.433 1.00 73.52 C ATOM 9638 CE1 PHE C 232 11.993 20.191 −32.128 1.00 73.80 C ATOM 9639 CZ PHE C 232 13.202 20.180 −32.807 1.00 76.12 C ATOM 9640 CE2 PHE C 232 13.454 19.222 −33.781 1.00 75.17 C ATOM 9641 CD2 PHE C 232 12.489 18.279 −34.078 1.00 74.16 C ATOM 9642 C PHE C 232 8.999 15.234 −32.885 1.00 61.58 C ATOM 9643 O PHE C 232 7.956 15.637 −33.432 1.00 56.44 O ATOM 9644 N HIS C 233 9.139 13.973 −32.460 1.00 62.84 N ATOM 9645 CA HIS C 233 8.069 12.990 −32.689 1.00 64.19 C ATOM 9646 CB HIS C 233 8.447 11.591 −32.161 1.00 71.54 C ATOM 9647 CG HIS C 233 7.371 10.561 −32.353 1.00 78.79 C ATOM 9648 ND1 HIS C 233 6.572 10.114 −31.319 1.00 86.04 N ATOM 9649 CE1 HIS C 233 5.697 9.241 −31.780 1.00 84.38 C ATOM 9650 NE2 HIS C 233 5.898 9.107 −33.079 1.00 85.13 N ATOM 9651 CD2 HIS C 233 6.941 9.918 −33.462 1.00 79.26 C ATOM 9652 C HIS C 233 6.775 13.496 −32.055 1.00 59.12 C ATOM 9653 O HIS C 233 5.702 13.445 −32.666 1.00 56.98 O ATOM 9654 N CYS C 234 6.888 14.057 −30.857 1.00 57.84 N ATOM 9655 CA CYS C 234 5.713 14.536 −30.162 1.00 59.74 C ATOM 9656 CB CYS C 234 5.996 14.702 −28.674 1.00 65.60 C ATOM 9657 SG CYS C 234 6.112 13.066 −27.895 1.00 75.39 S ATOM 9658 C CYS C 234 5.096 15.765 −30.798 1.00 55.59 C ATOM 9659 O CYS C 234 4.067 16.237 −30.338 1.00 59.11 O ATOM 9660 N ALA C 235 5.667 16.248 −31.897 1.00 52.95 N ATOM 9661 CA ALA C 235 4.982 17.240 −32.721 1.00 56.48 C ATOM 9662 CB ALA C 235 5.816 17.630 −33.934 1.00 56.85 C ATOM 9663 C ALA C 235 3.614 16.767 −33.176 1.00 57.69 C ATOM 9664 O ALA C 235 2.742 17.594 −33.464 1.00 56.76 O ATOM 9665 N ASN C 236 3.427 15.444 −33.237 1.00 60.89 N ATOM 9666 CA ASN C 236 2.151 14.863 −33.653 1.00 61.59 C ATOM 9667 CB ASN C 236 2.311 13.372 −33.896 1.00 68.05 C ATOM 9668 CG ASN C 236 2.871 13.085 −35.272 1.00 75.93 C ATOM 9669 OD1 ASN C 236 4.084 12.918 −35.430 1.00 82.92 O ATOM 9670 ND2 ASN C 236 1.990 13.052 −36.286 1.00 75.10 N ATOM 9671 C ASN C 236 0.981 15.127 −32.718 1.00 57.06 C ATOM 9672 O ASN C 236 −0.161 14.927 −33.115 1.00 52.90 O ATOM 9673 N LEU C 237 1.278 15.601 −31.507 1.00 51.47 N ATOM 9674 CA LEU C 237 0.279 15.937 −30.523 1.00 47.82 C ATOM 9675 CB LEU C 237 0.841 15.738 −29.134 1.00 52.03 C ATOM 9676 CG LEU C 237 1.575 14.407 −28.880 1.00 54.59 C ATOM 9677 CD1 LEU C 237 2.151 14.360 −27.471 1.00 55.55 C ATOM 9678 CD2 LEU C 237 0.650 13.246 −29.135 1.00 51.47 C ATOM 9679 C LEU C 237 −0.122 17.364 −30.624 1.00 46.73 C ATOM 9680 O LEU C 237 −1.108 17.742 −30.045 1.00 43.08 O ATOM 9681 N THR C 238 0.661 18.169 −31.329 1.00 53.28 N ATOM 9682 CA THR C 238 0.443 19.611 −31.422 1.00 54.27 C ATOM 9683 CB THR C 238 1.762 20.377 −31.440 1.00 55.98 C ATOM 9684 OG1 THR C 238 2.286 20.355 −32.772 1.00 54.95 O ATOM 9685 CG2 THR C 238 2.790 19.782 −30.444 1.00 55.10 C ATOM 9686 C THR C 238 −0.211 19.845 −32.753 1.00 55.28 C ATOM 9687 O THR C 238 −0.455 18.879 −33.462 1.00 56.51 O ATOM 9688 N SER C 239 −0.450 21.102 −33.131 1.00 56.83 N ATOM 9689 CA SER C 239 −1.003 21.370 −34.465 1.00 61.86 C ATOM 9690 CB SER C 239 −2.275 22.251 −34.402 1.00 63.29 C ATOM 9691 OG SER C 239 −2.054 23.565 −33.965 1.00 65.25 O ATOM 9692 C SER C 239 0.051 21.821 −35.503 1.00 60.84 C ATOM 9693 O SER C 239 −0.306 22.545 −36.450 1.00 58.85 O ATOM 9694 N TRP C 240 1.310 21.348 −35.344 1.00 58.74 N ATOM 9695 CA TRP C 240 2.430 21.624 −36.286 1.00 58.34 C ATOM 9696 CB TRP C 240 3.170 22.932 −35.904 1.00 61.57 C ATOM 9697 CG TRP C 240 2.481 24.048 −36.556 1.00 65.59 C ATOM 9698 CD1 TRP C 240 2.336 24.281 −37.924 1.00 74.23 C ATOM 9699 NE1 TRP C 240 1.558 25.378 −38.153 1.00 72.97 N ATOM 9700 CE2 TRP C 240 1.172 25.865 −36.945 1.00 67.79 C ATOM 9701 CD2 TRP C 240 1.749 25.036 −35.921 1.00 59.98 C ATOM 9702 CE3 TRP C 240 1.514 25.322 −34.603 1.00 55.20 C ATOM 9703 CZ3 TRP C 240 0.741 26.365 −34.326 1.00 64.99 C ATOM 9704 CH2 TRP C 240 0.184 27.189 −35.368 1.00 74.61 C ATOM 9705 CZ2 TRP C 240 0.402 26.938 −36.673 1.00 67.22 C ATOM 9706 C TRP C 240 3.468 20.505 −36.571 1.00 57.59 C ATOM 9707 O TRP C 240 3.609 19.554 −35.810 1.00 69.85 O ATOM 9708 N PRO C 241 4.200 20.624 −37.692 1.00 53.99 N ATOM 9709 CA PRO C 241 5.189 19.631 −38.070 1.00 54.08 C ATOM 9710 CB PRO C 241 5.463 19.937 −39.535 1.00 55.17 C ATOM 9711 CG PRO C 241 4.592 21.044 −39.939 1.00 53.33 C ATOM 9712 CD PRO C 241 3.985 21.621 −38.751 1.00 54.28 C ATOM 9713 C PRO C 241 6.533 19.656 −37.372 1.00 55.90 C ATOM 9714 O PRO C 241 6.984 20.668 −36.858 1.00 53.72 O ATOM 9715 N ARG C 242 7.216 18.534 −37.483 1.00 61.02 N ATOM 9716 CA ARG C 242 8.569 18.426 −36.980 1.00 66.20 C ATOM 9717 CB ARG C 242 9.129 17.012 −37.209 1.00 71.48 C ATOM 9718 CG ARG C 242 8.155 15.877 −36.837 1.00 87.64 C ATOM 9719 CD ARG C 242 8.838 14.516 −36.607 1.00 99.23 C ATOM 9720 NE ARG C 242 8.168 13.402 −37.293 1.00 94.22 N ATOM 9721 CZ ARG C 242 8.156 13.218 −38.619 1.00 86.41 C ATOM 9722 NH1 ARG C 242 8.768 14.072 −39.448 1.00 74.02 N ATOM 9723 NH2 ARG C 242 7.510 12.172 −39.132 1.00 95.36 N ATOM 9724 C ARG C 242 9.432 19.500 −37.664 1.00 64.77 C ATOM 9725 O ARG C 242 10.319 20.072 −37.032 1.00 66.81 O ATOM 9726 N TRP C 243 9.161 19.774 −38.947 1.00 62.61 N ATOM 9727 CA TRP C 243 9.956 20.746 −39.722 1.00 59.00 C ATOM 9728 CB TRP C 243 9.796 20.600 −41.252 1.00 49.73 C ATOM 9729 CG TRP C 243 8.458 20.845 −41.801 1.00 44.84 C ATOM 9730 CD1 TRP C 243 7.538 19.902 −42.094 1.00 45.53 C ATOM 9731 NE1 TRP C 243 6.383 20.488 −42.592 1.00 45.30 N ATOM 9732 CE2 TRP C 243 6.564 21.839 −42.649 1.00 41.61 C ATOM 9733 CD2 TRP C 243 7.872 22.106 −42.159 1.00 41.95 C ATOM 9734 CE3 TRP C 243 8.300 23.419 −42.086 1.00 41.35 C ATOM 9735 CZ3 TRP C 243 7.416 24.423 −42.502 1.00 44.23 C ATOM 9736 CH2 TRP C 243 6.121 24.116 −43.004 1.00 40.74 C ATOM 9737 CZ2 TRP C 243 5.686 22.836 −43.075 1.00 39.38 C ATOM 9738 C TRP C 243 9.760 22.197 −39.287 1.00 63.47 C ATOM 9739 O TRP C 243 10.691 22.997 −39.426 1.00 67.76 O ATOM 9740 N LEU C 244 8.585 22.534 −38.755 1.00 62.07 N ATOM 9741 CA LEU C 244 8.404 23.836 −38.116 1.00 60.66 C ATOM 9742 CB LEU C 244 6.938 24.162 −37.909 1.00 59.51 C ATOM 9743 CG LEU C 244 6.702 25.488 −37.192 1.00 59.78 C ATOM 9744 CD1 LEU C 244 7.500 26.629 −37.796 1.00 61.45 C ATOM 9745 CD2 LEU C 244 5.230 25.795 −37.276 1.00 64.08 C ATOM 9746 C LEU C 244 9.118 23.913 −36.769 1.00 62.02 C ATOM 9747 O LEU C 244 9.871 24.841 −36.540 1.00 65.00 O ATOM 9748 N TYR C 245 8.880 22.959 −35.873 1.00 60.22 N ATOM 9749 CA TYR C 245 9.584 22.961 −34.590 1.00 59.98 C ATOM 9750 CB TYR C 245 9.134 21.784 −33.675 1.00 69.13 C ATOM 9751 CG TYR C 245 7.702 21.941 −33.183 1.00 58.82 C ATOM 9752 CD1 TYR C 245 7.375 22.935 −32.281 1.00 57.57 C ATOM 9753 CE1 TYR C 245 6.079 23.115 −31.850 1.00 57.91 C ATOM 9754 CZ TYR C 245 5.079 22.295 −32.311 1.00 58.80 C ATOM 9755 OH TYR C 245 3.811 22.540 −31.861 1.00 58.40 O ATOM 9756 CE2 TYR C 245 5.361 21.284 −33.211 1.00 57.85 C ATOM 9757 CD2 TYR C 245 6.669 21.117 −33.649 1.00 61.00 C ATOM 9758 C TYR C 245 11.124 23.019 −34.787 1.00 61.17 C ATOM 9759 O TYR C 245 11.830 23.627 −33.959 1.00 67.17 O ATOM 9760 N SER C 246 11.630 22.450 −35.891 1.00 58.72 N ATOM 9761 CA SER C 246 13.081 22.444 −36.171 1.00 60.73 C ATOM 9762 CB SER C 246 13.443 21.467 −37.321 1.00 58.19 C ATOM 9763 OG SER C 246 14.649 20.740 −37.027 1.00 59.16 O ATOM 9764 C SER C 246 13.627 23.865 −36.429 1.00 60.03 C ATOM 9765 O SER C 246 14.749 24.192 −36.040 1.00 58.17 O ATOM 9766 N LEU C 247 12.801 24.700 −37.055 1.00 60.87 N ATOM 9767 CA LEU C 247 13.104 26.119 −37.275 1.00 59.16 C ATOM 9768 CB LEU C 247 12.094 26.738 −38.256 1.00 55.85 C ATOM 9769 CG LEU C 247 12.163 26.200 −39.681 1.00 54.10 C ATOM 9770 CD1 LEU C 247 10.986 26.677 −40.513 1.00 54.36 C ATOM 9771 CD2 LEU C 247 13.478 26.601 −40.320 1.00 57.05 C ATOM 9772 C LEU C 247 13.158 26.995 −36.011 1.00 61.67 C ATOM 9773 O LEU C 247 13.624 28.130 −36.103 1.00 63.33 O ATOM 9774 N TYR C 248 12.678 26.510 −34.859 1.00 57.99 N ATOM 9775 CA TYR C 248 12.933 27.188 −33.581 1.00 54.97 C ATOM 9776 CB TYR C 248 11.631 27.524 −32.895 1.00 55.17 C ATOM 9777 CG TYR C 248 10.782 28.516 −33.635 1.00 60.07 C ATOM 9778 CD1 TYR C 248 9.838 28.101 −34.568 1.00 60.73 C ATOM 9779 CE1 TYR C 248 9.016 29.018 −35.218 1.00 61.48 C ATOM 9780 CZ TYR C 248 9.144 30.362 −34.953 1.00 61.97 C ATOM 9781 OH TYR C 248 8.350 31.273 −35.595 1.00 61.64 O ATOM 9782 CE2 TYR C 248 10.073 30.797 −34.030 1.00 65.85 C ATOM 9783 CD2 TYR C 248 10.883 29.875 −33.372 1.00 63.01 C ATOM 9784 C TYR C 248 13.814 26.382 −32.639 1.00 51.69 C ATOM 9785 O TYR C 248 13.725 26.541 −31.419 1.00 55.77 O ATOM 9786 N ASP C 249 14.698 25.559 −33.194 1.00 47.71 N ATOM 9787 CA ASP C 249 15.507 24.649 −32.377 1.00 49.29 C ATOM 9788 CB ASP C 249 15.516 23.218 −32.983 1.00 50.49 C ATOM 9789 CG ASP C 249 16.340 22.188 −32.141 1.00 50.38 C ATOM 9790 OD1 ASP C 249 16.167 22.001 −30.924 1.00 48.46 O ATOM 9791 OD2 ASP C 249 17.168 21.512 −32.740 1.00 55.10 O ATOM 9792 C ASP C 249 16.905 25.165 −32.304 1.00 45.92 C ATOM 9793 O ASP C 249 17.575 25.144 −33.320 1.00 50.53 O ATOM 9794 N ALA C 250 17.378 25.559 −31.121 1.00 44.56 N ATOM 9795 CA ALA C 250 18.735 26.143 −30.994 1.00 44.29 C ATOM 9796 CB ALA C 250 19.220 26.290 −29.547 1.00 38.91 C ATOM 9797 C ALA C 250 19.730 25.331 −31.805 1.00 50.14 C ATOM 9798 O ALA C 250 20.396 25.867 −32.689 1.00 60.18 O ATOM 9799 N GLU C 251 19.782 24.038 −31.551 1.00 53.06 N ATOM 9800 CA GLU C 251 20.836 23.197 −32.093 1.00 56.16 C ATOM 9801 CB GLU C 251 20.732 21.813 −31.454 1.00 66.43 C ATOM 9802 CG GLU C 251 21.479 21.695 −30.141 1.00 71.00 C ATOM 9803 CD GLU C 251 22.997 21.734 −30.346 1.00 77.05 C ATOM 9804 OE1 GLU C 251 23.491 21.584 −31.525 1.00 77.89 O ATOM 9805 OE2 GLU C 251 23.683 21.926 −29.302 1.00 78.52 O ATOM 9806 C GLU C 251 20.813 23.091 −33.608 1.00 51.73 C ATOM 9807 O GLU C 251 21.848 23.229 −34.246 1.00 50.63 O ATOM 9808 N THR C 252 19.636 22.850 −34.167 1.00 49.50 N ATOM 9809 CA THR C 252 19.466 22.911 −35.590 1.00 50.62 C ATOM 9810 CB THR C 252 17.995 22.683 −36.046 1.00 51.12 C ATOM 9811 OG1 THR C 252 17.437 21.437 −35.604 1.00 49.00 O ATOM 9812 CG2 THR C 252 17.960 22.700 −37.557 1.00 53.71 C ATOM 9813 C THR C 252 19.946 24.324 −36.103 1.00 51.51 C ATOM 9814 O THR C 252 20.736 24.413 −37.043 1.00 51.17 O ATOM 9815 N LEU C 253 19.473 25.413 −35.489 1.00 50.28 N ATOM 9816 CA LEU C 253 19.836 26.783 −35.916 1.00 49.76 C ATOM 9817 CB LEU C 253 19.091 27.819 −35.081 1.00 52.09 C ATOM 9818 CG LEU C 253 17.553 27.919 −35.132 1.00 54.12 C ATOM 9819 CD1 LEU C 253 17.022 28.637 −33.904 1.00 55.56 C ATOM 9820 CD2 LEU C 253 17.087 28.682 −36.347 1.00 54.30 C ATOM 9821 C LEU C 253 21.340 27.084 −35.801 1.00 50.33 C ATOM 9822 O LEU C 253 21.893 27.774 −36.639 1.00 46.58 O ATOM 9823 N MET C 254 22.006 26.592 −34.752 1.00 54.36 N ATOM 9824 CA MET C 254 23.466 26.767 −34.617 1.00 54.30 C ATOM 9825 CB MET C 254 24.001 26.298 −33.264 1.00 58.02 C ATOM 9826 CG MET C 254 23.645 27.221 −32.105 1.00 62.52 C ATOM 9827 SD MET C 254 24.347 26.667 −30.522 1.00 69.15 S ATOM 9828 CE MET C 254 22.901 25.870 −29.873 1.00 66.84 C ATOM 9829 C MET C 254 24.166 26.037 −35.737 1.00 52.91 C ATOM 9830 O MET C 254 25.002 26.608 −36.402 1.00 48.43 O ATOM 9831 N ASP C 255 23.800 24.787 −35.987 1.00 55.59 N ATOM 9832 CA ASP C 255 24.431 24.066 −37.093 1.00 57.64 C ATOM 9833 CB ASP C 255 24.007 22.586 −37.073 1.00 61.03 C ATOM 9834 CG ASP C 255 24.623 21.766 −38.234 1.00 65.64 C ATOM 9835 OD1 ASP C 255 25.822 21.383 −38.033 1.00 64.58 O ATOM 9836 OD2 ASP C 255 23.895 21.519 −39.289 1.00 57.57 O ATOM 9837 C ASP C 255 24.214 24.763 −38.488 1.00 52.82 C ATOM 9838 O ASP C 255 25.106 24.799 −39.318 1.00 48.47 O ATOM 9839 N ARG C 256 23.051 25.345 −38.725 1.00 51.66 N ATOM 9840 CA ARG C 256 22.809 26.075 −39.990 1.00 53.45 C ATOM 9841 CB ARG C 256 21.318 26.459 −40.108 1.00 51.60 C ATOM 9842 CG ARG C 256 20.422 25.308 −40.514 1.00 49.55 C ATOM 9843 CD ARG C 256 18.974 25.687 −40.429 1.00 49.04 C ATOM 9844 NE ARG C 256 18.677 26.752 −41.361 1.00 49.06 N ATOM 9845 CZ ARG C 256 17.658 27.611 −41.269 1.00 53.96 C ATOM 9846 NH1 ARG C 256 16.746 27.547 −40.289 1.00 58.53 N ATOM 9847 NH2 ARG C 256 17.539 28.570 −42.182 1.00 55.13 N ATOM 9848 C ARG C 256 23.720 27.321 −40.171 1.00 54.69 C ATOM 9849 O ARG C 256 24.292 27.560 −41.262 1.00 53.34 O ATOM 9850 N ILE C 257 23.841 28.092 −39.091 1.00 56.12 N ATOM 9851 CA ILE C 257 24.777 29.206 −39.038 1.00 60.71 C ATOM 9852 CB ILE C 257 24.701 30.008 −37.710 1.00 58.11 C ATOM 9853 CG1 ILE C 257 23.324 30.613 −37.524 1.00 55.91 C ATOM 9854 CD1 ILE C 257 23.045 30.854 −36.075 1.00 57.77 C ATOM 9855 CG2 ILE C 257 25.758 31.126 −37.667 1.00 57.74 C ATOM 9856 C ILE C 257 26.217 28.696 −39.224 1.00 63.16 C ATOM 9857 O ILE C 257 27.014 29.352 −39.888 1.00 72.69 O ATOM 9858 N LYS C 258 26.547 27.541 −38.656 1.00 61.72 N ATOM 9859 CA LYS C 258 27.900 27.034 −38.749 1.00 60.94 C ATOM 9860 CB LYS C 258 28.093 25.782 −37.941 1.00 62.36 C ATOM 9861 CG LYS C 258 28.266 26.002 −36.475 1.00 66.71 C ATOM 9862 CD LYS C 258 28.283 24.634 −35.830 1.00 73.39 C ATOM 9863 CE LYS C 258 28.892 24.645 −34.448 1.00 77.70 C ATOM 9864 NZ LYS C 258 28.819 23.248 −33.957 1.00 79.38 N ATOM 9865 C LYS C 258 28.284 26.718 −40.152 1.00 62.35 C ATOM 9866 O LYS C 258 29.441 26.497 −40.408 1.00 67.86 O ATOM 9867 N LYS C 259 27.332 26.668 −41.062 1.00 66.64 N ATOM 9868 CA LYS C 259 27.664 26.402 −42.426 1.00 71.48 C ATOM 9869 CB LYS C 259 26.544 25.658 −43.093 1.00 72.80 C ATOM 9870 CG LYS C 259 26.548 24.249 −42.571 1.00 76.72 C ATOM 9871 CD LYS C 259 25.215 23.558 −42.660 1.00 81.57 C ATOM 9872 CE LYS C 259 25.395 22.118 −42.210 1.00 88.20 C ATOM 9873 NZ LYS C 259 24.368 21.263 −42.852 1.00 95.48 N ATOM 9874 C LYS C 259 28.064 27.646 −43.159 1.00 79.30 C ATOM 9875 O LYS C 259 29.022 27.541 −43.906 1.00 90.65 O ATOM 9876 N GLN C 260 27.425 28.819 −42.950 1.00 86.51 N ATOM 9877 CA GLN C 260 28.027 30.095 −43.522 1.00 91.27 C ATOM 9878 CB GLN C 260 27.149 31.400 −43.633 1.00 94.88 C ATOM 9879 CG GLN C 260 25.625 31.355 −43.427 1.00 104.21 C ATOM 9880 CD GLN C 260 24.806 30.468 −44.379 1.00 102.82 C ATOM 9881 OE1 GLN C 260 23.562 30.512 −44.369 1.00 92.30 O ATOM 9882 NE2 GLN C 260 25.482 29.647 −45.169 1.00 103.01 N ATOM 9883 C GLN C 260 29.349 30.400 −42.813 1.00 78.57 C ATOM 9884 O GLN C 260 30.259 30.922 −43.430 1.00 85.82 O ATOM 9885 N LEU C 261 29.476 30.037 −41.553 1.00 68.99 N ATOM 9886 CA LEU C 261 30.778 30.120 −40.886 1.00 71.21 C ATOM 9887 CB LEU C 261 30.642 29.922 −39.365 1.00 67.62 C ATOM 9888 CG LEU C 261 29.826 30.958 −38.572 1.00 67.41 C ATOM 9889 CD1 LEU C 261 29.905 30.630 −37.091 1.00 65.89 C ATOM 9890 CD2 LEU C 261 30.286 32.400 −38.838 1.00 69.25 C ATOM 9891 C LEU C 261 31.865 29.171 −41.428 1.00 74.55 C ATOM 9892 O LEU C 261 33.051 29.528 −41.404 1.00 75.53 O ATOM 9893 N ARG C 262 31.491 27.976 −41.889 1.00 79.28 N ATOM 9894 CA ARG C 262 32.478 27.057 −42.476 1.00 82.08 C ATOM 9895 CB ARG C 262 31.924 25.639 −42.661 1.00 90.78 C ATOM 9896 CG ARG C 262 32.963 24.516 −42.517 1.00 100.04 C ATOM 9897 CD ARG C 262 32.319 23.114 −42.464 1.00 107.07 C ATOM 9898 NE ARG C 262 31.336 22.962 −41.369 1.00 108.21 N ATOM 9899 CZ ARG C 262 31.627 22.768 −40.075 1.00 108.25 C ATOM 9900 NH1 ARG C 262 32.892 22.682 −39.650 1.00 112.35 N ATOM 9901 NH2 ARG C 262 30.641 22.668 −39.185 1.00 104.36 N ATOM 9902 C ARG C 262 33.002 27.598 −43.804 1.00 78.74 C ATOM 9903 O ARG C 262 34.153 27.358 −44.125 1.00 87.52 O ATOM 9904 N GLU C 263 32.211 28.342 −44.554 1.00 71.98 N ATOM 9905 CA GLU C 263 32.752 28.851 −45.795 1.00 75.35 C ATOM 9906 CB GLU C 263 31.684 29.109 −46.826 1.00 78.86 C ATOM 9907 CG GLU C 263 30.637 30.077 −46.401 1.00 87.82 C ATOM 9908 CD GLU C 263 29.562 30.167 −47.436 1.00 96.74 C ATOM 9909 OE1 GLU C 263 29.232 29.123 −48.019 1.00 89.56 O ATOM 9910 OE2 GLU C 263 29.060 31.277 −47.668 1.00 107.65 O ATOM 9911 C GLU C 263 33.663 30.043 −45.583 1.00 73.97 C ATOM 9912 O GLU C 263 34.587 30.251 −46.338 1.00 77.78 O ATOM 9913 N TRP C 264 33.398 30.842 −44.570 1.00 73.71 N ATOM 9914 CA TRP C 264 34.290 31.928 −44.233 1.00 71.00 C ATOM 9915 CB TRP C 264 33.669 32.833 −43.196 1.00 70.18 C ATOM 9916 CG TRP C 264 32.533 33.574 −43.746 1.00 66.22 C ATOM 9917 CD1 TRP C 264 32.217 33.709 −45.047 1.00 66.03 C ATOM 9918 NE1 TRP C 264 31.105 34.475 −45.188 1.00 63.82 N ATOM 9919 CE2 TRP C 264 30.683 34.857 −43.950 1.00 60.86 C ATOM 9920 CD2 TRP C 264 31.566 34.312 −43.023 1.00 63.81 C ATOM 9921 CE3 TRP C 264 31.348 34.551 −41.676 1.00 66.60 C ATOM 9922 CZ3 TRP C 264 30.289 35.315 −41.316 1.00 68.19 C ATOM 9923 CH2 TRP C 264 29.440 35.850 −42.259 1.00 63.45 C ATOM 9924 CZ2 TRP C 264 29.617 35.630 −43.582 1.00 59.24 C ATOM 9925 C TRP C 264 35.550 31.261 −43.713 1.00 76.45 C ATOM 9926 O TRP C 264 36.656 31.680 −43.982 1.00 70.93 O ATOM 9927 N ASP C 265 35.329 30.194 −42.952 1.00 85.62 N ATOM 9928 CA ASP C 265 36.351 29.333 −42.359 1.00 82.69 C ATOM 9929 CB ASP C 265 37.355 28.885 −43.407 1.00 83.49 C ATOM 9930 CG ASP C 265 37.785 27.454 −43.221 1.00 85.85 C ATOM 9931 OD1 ASP C 265 38.205 27.102 −42.107 1.00 87.40 O ATOM 9932 OD2 ASP C 265 37.712 26.680 −44.190 1.00 79.43 O ATOM 9933 C ASP C 265 37.062 29.924 −41.170 1.00 82.49 C ATOM 9934 O ASP C 265 37.949 29.298 −40.610 1.00 73.71 O ATOM 9935 N ASP C 270 35.989 25.968 −39.580 1.00 72.36 N ATOM 9936 CA ASP C 270 37.196 25.170 −39.547 1.00 86.48 C ATOM 9937 CB ASP C 270 38.271 25.746 −40.478 1.00 82.60 C ATOM 9938 C ASP C 270 37.639 25.229 −38.122 1.00 90.78 C ATOM 9939 O ASP C 270 38.719 25.713 −37.824 1.00 84.79 O ATOM 9940 N ASP C 271 36.785 24.739 −37.232 1.00 101.59 N ATOM 9941 CA ASP C 271 37.093 24.762 −35.815 1.00 107.33 C ATOM 9942 CB ASP C 271 37.585 26.145 −35.409 1.00 103.38 C ATOM 9943 C ASP C 271 35.920 24.375 −34.937 1.00 112.23 C ATOM 9944 O ASP C 271 34.952 23.773 −35.391 1.00 100.91 O ATOM 9945 N SER C 272 36.046 24.719 −33.661 1.00 122.93 N ATOM 9946 CA SER C 272 35.035 24.452 −32.651 1.00 122.81 C ATOM 9947 CB SER C 272 35.590 23.527 −31.584 1.00 110.79 C ATOM 9948 OG SER C 272 36.162 22.390 −32.187 1.00 101.24 O ATOM 9949 C SER C 272 34.552 25.753 −32.020 1.00 121.46 C ATOM 9950 O SER C 272 35.337 26.653 −31.724 1.00 103.59 O ATOM 9951 N LEU C 273 33.242 25.832 −31.820 1.00 123.28 N ATOM 9952 CA LEU C 273 32.585 27.003 −31.259 1.00 116.79 C ATOM 9953 CB LEU C 273 31.741 27.703 −32.306 1.00 117.04 C ATOM 9954 CG LEU C 273 32.512 28.587 −33.274 1.00 114.95 C ATOM 9955 CD1 LEU C 273 33.927 28.095 −33.522 1.00 115.59 C ATOM 9956 CD2 LEU C 273 31.741 28.670 −34.571 1.00 107.70 C ATOM 9957 C LEU C 273 31.748 26.668 −30.050 1.00 111.56 C ATOM 9958 O LEU C 273 31.462 25.512 −29.771 1.00 121.15 O ATOM 9959 N PRO C 274 31.362 27.762 −29.300 1.00 106.85 N ATOM 9960 CA PRO C 274 30.634 27.433 −28.068 1.00 104.93 C ATOM 9961 CB PRO C 274 30.226 28.802 −27.520 1.00 102.73 C ATOM 9962 CG PRO C 274 31.201 29.751 −28.056 1.00 102.92 C ATOM 9963 CD PRO C 274 31.344 29.285 −29.450 1.00 105.09 C ATOM 9964 C PRO C 274 29.372 26.595 −28.091 1.00 102.65 C ATOM 9965 O PRO C 274 28.454 26.893 −28.820 1.00 105.18 O ATOM 9966 N SER C 275 29.327 25.567 −27.257 1.00 95.38 N ATOM 9967 CA SER C 275 28.097 24.797 −27.045 1.00 84.85 C ATOM 9968 CB SER C 275 28.280 23.803 −25.882 1.00 85.79 C ATOM 9969 OG SER C 275 29.646 23.635 −25.544 1.00 87.81 O ATOM 9970 C SER C 275 26.892 25.719 −26.722 1.00 77.02 C ATOM 9971 O SER C 275 25.804 25.534 −27.244 1.00 70.76 O ATOM 9972 N ASN C 276 27.078 26.717 −25.864 1.00 72.54 N ATOM 9973 CA ASN C 276 25.931 27.481 −25.408 1.00 67.97 C ATOM 9974 CB ASN C 276 26.292 28.373 −24.230 1.00 70.85 C ATOM 9975 CG ASN C 276 25.056 28.861 −23.484 1.00 76.37 C ATOM 9976 OD1 ASN C 276 24.215 29.592 −24.025 1.00 81.18 O ATOM 9977 ND2 ASN C 276 24.928 28.449 −22.239 1.00 78.65 N ATOM 9978 C ASN C 276 25.253 28.327 −26.511 1.00 65.01 C ATOM 9979 O ASN C 276 25.871 29.216 −27.124 1.00 63.06 O ATOM 9980 N PRO C 277 23.964 28.085 −26.742 1.00 58.92 N ATOM 9981 CA PRO C 277 23.190 29.007 −27.565 1.00 59.42 C ATOM 9982 CB PRO C 277 21.754 28.586 −27.311 1.00 56.38 C ATOM 9983 CG PRO C 277 21.822 27.216 −26.794 1.00 55.10 C ATOM 9984 CD PRO C 277 23.141 27.032 −26.154 1.00 55.93 C ATOM 9985 C PRO C 277 23.389 30.521 −27.241 1.00 61.01 C ATOM 9986 O PRO C 277 23.714 31.275 −28.125 1.00 75.08 O ATOM 9987 N ILE C 278 23.238 30.976 −26.014 1.00 61.07 N ATOM 9988 CA ILE C 278 23.538 32.379 −25.728 1.00 61.43 C ATOM 9989 CB ILE C 278 23.586 32.646 −24.229 1.00 57.67 C ATOM 9990 CG1 ILE C 278 22.212 32.512 −23.642 1.00 57.15 C ATOM 9991 CD1 ILE C 278 22.261 32.240 −22.170 1.00 60.10 C ATOM 9992 CG2 ILE C 278 24.052 34.062 −23.990 1.00 59.03 C ATOM 9993 C ILE C 278 24.916 32.803 −26.301 1.00 64.79 C ATOM 9994 O ILE C 278 25.043 33.798 −27.058 1.00 55.87 O ATOM 9995 N ASP C 279 25.939 32.030 −25.921 1.00 66.93 N ATOM 9996 CA ASP C 279 27.328 32.364 −26.249 1.00 67.06 C ATOM 9997 CB ASP C 279 28.317 31.455 −25.509 1.00 70.56 C ATOM 9998 CG ASP C 279 28.299 31.684 −23.995 1.00 75.30 C ATOM 9999 OD1 ASP C 279 27.588 32.601 −23.495 1.00 75.41 O ATOM 10000 OD2 ASP C 279 28.999 30.929 −23.302 1.00 82.09 O ATOM 10001 C ASP C 279 27.556 32.324 −27.733 1.00 59.14 C ATOM 10002 O ASP C 279 27.944 33.311 −28.330 1.00 61.45 O ATOM 10003 N PHE C 280 27.268 31.199 −28.335 1.00 53.48 N ATOM 10004 CA PHE C 280 27.249 31.137 −29.785 1.00 52.81 C ATOM 10005 CB PHE C 280 26.538 29.861 −30.257 1.00 52.64 C ATOM 10006 CG PHE C 280 26.758 29.547 −31.700 1.00 51.37 C ATOM 10007 CD2 PHE C 280 25.860 29.964 −32.651 1.00 51.85 C ATOM 10008 CE2 PHE C 280 26.040 29.677 −33.984 1.00 52.24 C ATOM 10009 CZ PHE C 280 27.145 28.957 −34.373 1.00 56.25 C ATOM 10010 CE1 PHE C 280 28.050 28.518 −33.415 1.00 57.45 C ATOM 10011 CD1 PHE C 280 27.854 28.830 −32.090 1.00 53.95 C ATOM 10012 C PHE C 280 26.568 32.374 −30.376 1.00 48.86 C ATOM 10013 O PHE C 280 27.170 33.096 −31.157 1.00 49.19 O ATOM 10014 N SER C 281 25.343 32.640 −29.959 1.00 45.41 N ATOM 10015 CA SER C 281 24.576 33.699 −30.554 1.00 47.73 C ATOM 10016 CB SER C 281 23.148 33.763 −29.987 1.00 49.00 C ATOM 10017 OG SER C 281 23.103 34.532 −28.801 1.00 51.42 O ATOM 10018 C SER C 281 25.261 35.075 −30.445 1.00 48.28 C ATOM 10019 O SER C 281 25.157 35.877 −31.367 1.00 45.65 O ATOM 10020 N TYR C 282 25.952 35.336 −29.335 1.00 49.76 N ATOM 10021 CA TYR C 282 26.722 36.591 −29.182 1.00 49.30 C ATOM 10022 CB TYR C 282 27.046 36.907 −27.716 1.00 47.42 C ATOM 10023 CG TYR C 282 25.877 37.453 −26.984 1.00 46.84 C ATOM 10024 CD1 TYR C 282 25.106 38.450 −27.536 1.00 49.64 C ATOM 10025 CE1 TYR C 282 24.004 38.937 −26.901 1.00 51.66 C ATOM 10026 CZ TYR C 282 23.681 38.435 −25.687 1.00 51.99 C ATOM 10027 OH TYR C 282 22.593 38.953 −25.053 1.00 67.24 O ATOM 10028 CE2 TYR C 282 24.402 37.427 −25.118 1.00 47.77 C ATOM 10029 CD2 TYR C 282 25.497 36.939 −25.775 1.00 47.04 C ATOM 10030 C TYR C 282 28.009 36.616 −29.978 1.00 52.26 C ATOM 10031 O TYR C 282 28.453 37.678 −30.407 1.00 53.45 O ATOM 10032 N ARG C 283 28.600 35.451 −30.157 1.00 56.28 N ATOM 10033 CA ARG C 283 29.750 35.344 −30.997 1.00 59.67 C ATOM 10034 CB ARG C 283 30.350 33.944 −30.916 1.00 69.46 C ATOM 10035 CG ARG C 283 31.779 33.862 −31.427 1.00 82.10 C ATOM 10036 CD ARG C 283 32.791 34.581 −30.523 1.00 89.24 C ATOM 10037 NE ARG C 283 33.820 33.622 −30.126 1.00 100.19 N ATOM 10038 CZ ARG C 283 33.733 32.769 −29.092 1.00 109.61 C ATOM 10039 NH1 ARG C 283 34.740 31.918 −28.855 1.00 112.90 N ATOM 10040 NH2 ARG C 283 32.674 32.764 −28.269 1.00 109.41 N ATOM 10041 C ARG C 283 29.359 35.703 −32.429 1.00 53.64 C ATOM 10042 O ARG C 283 30.011 36.530 −33.034 1.00 46.54 O ATOM 10043 N VAL C 284 28.283 35.138 −32.966 1.00 50.99 N ATOM 10044 CA VAL C 284 28.090 35.313 −34.388 1.00 52.17 C ATOM 10045 CB VAL C 284 27.199 34.258 −35.128 1.00 55.21 C ATOM 10046 CG1 VAL C 284 27.021 32.991 −34.310 1.00 56.37 C ATOM 10047 CG2 VAL C 284 25.865 34.824 −35.637 1.00 53.87 C ATOM 10048 C VAL C 284 27.627 36.719 −34.576 1.00 52.13 C ATOM 10049 O VAL C 284 27.886 37.304 −35.613 1.00 56.73 O ATOM 10050 N ALA C 285 26.970 37.272 −33.570 1.00 51.83 N ATOM 10051 CA ALA C 285 26.529 38.665 −33.631 1.00 52.06 C ATOM 10052 CB ALA C 285 25.948 39.109 −32.310 1.00 51.27 C ATOM 10053 C ALA C 285 27.638 39.594 −34.012 1.00 54.02 C ATOM 10054 O ALA C 285 27.415 40.497 −34.831 1.00 59.06 O ATOM 10055 N ALA C 286 28.814 39.384 −33.407 1.00 56.11 N ATOM 10056 CA ALA C 286 30.018 40.204 −33.680 1.00 57.23 C ATOM 10057 CB ALA C 286 31.102 39.987 −32.641 1.00 58.16 C ATOM 10058 C ALA C 286 30.610 40.044 −35.067 1.00 58.41 C ATOM 10059 O ALA C 286 31.097 40.986 −35.577 1.00 65.42 O ATOM 10060 N CYS C 287 30.562 38.880 −35.687 1.00 64.17 N ATOM 10061 CA CYS C 287 30.903 38.743 −37.117 1.00 67.80 C ATOM 10062 CB CYS C 287 30.660 37.309 −37.573 1.00 73.27 C ATOM 10063 SG CYS C 287 31.392 36.131 −36.464 1.00 82.76 S ATOM 10064 C CYS C 287 30.079 39.590 −38.087 1.00 63.51 C ATOM 10065 O CYS C 287 30.453 39.747 −39.231 1.00 64.16 O ATOM 10066 N LEU C 288 28.917 40.057 −37.699 1.00 60.32 N ATOM 10067 CA LEU C 288 28.076 40.632 −38.702 1.00 62.82 C ATOM 10068 CB LEU C 288 26.616 40.414 −38.390 1.00 63.18 C ATOM 10069 CG LEU C 288 26.160 39.025 −38.030 1.00 63.29 C ATOM 10070 CD1 LEU C 288 24.647 39.091 −38.140 1.00 63.51 C ATOM 10071 CD2 LEU C 288 26.776 37.922 −38.908 1.00 66.66 C ATOM 10072 C LEU C 288 28.346 42.120 −38.883 1.00 65.85 C ATOM 10073 O LEU C 288 28.172 42.910 −37.898 1.00 57.97 O ATOM 10074 N PRO C 289 28.751 42.496 −40.136 1.00 71.69 N ATOM 10075 CA PRO C 289 28.918 43.885 −40.534 1.00 74.49 C ATOM 10076 CB PRO C 289 29.705 43.780 −41.839 1.00 75.98 C ATOM 10077 CG PRO C 289 29.256 42.479 −42.458 1.00 74.09 C ATOM 10078 CD PRO C 289 28.951 41.584 −41.300 1.00 73.51 C ATOM 10079 C PRO C 289 27.541 44.431 −40.779 1.00 76.02 C ATOM 10080 O PRO C 289 26.971 44.241 −41.865 1.00 74.09 O ATOM 10081 N ILE C 290 26.993 45.021 −39.728 1.00 75.03 N ATOM 10082 CA ILE C 290 25.654 45.591 −39.744 1.00 77.74 C ATOM 10083 CB ILE C 290 24.589 44.714 −38.990 1.00 78.37 C ATOM 10084 CG1 ILE C 290 25.027 44.358 −37.559 1.00 78.45 C ATOM 10085 CD1 ILE C 290 23.879 43.893 −36.704 1.00 75.12 C ATOM 10086 CG2 ILE C 290 24.253 43.430 −39.746 1.00 74.27 C ATOM 10087 C ILE C 290 25.769 46.958 −39.105 1.00 76.08 C ATOM 10088 O ILE C 290 26.740 47.215 −38.420 1.00 68.41 O ATOM 10089 N ASP C 291 24.781 47.822 −39.328 1.00 81.29 N ATOM 10090 CA ASP C 291 24.826 49.185 −38.789 1.00 84.93 C ATOM 10091 CB ASP C 291 23.919 50.186 −39.542 1.00 96.32 C ATOM 10092 CG ASP C 291 22.478 49.706 −39.695 1.00 108.44 C ATOM 10093 OD1 ASP C 291 22.251 48.667 −40.374 1.00 116.16 O ATOM 10094 OD2 ASP C 291 21.574 50.390 −39.161 1.00 117.36 O ATOM 10095 C ASP C 291 24.505 49.148 −37.326 1.00 75.76 C ATOM 10096 O ASP C 291 23.997 48.154 −36.838 1.00 69.00 O ATOM 10097 N ASP C 292 24.825 50.248 −36.652 1.00 76.41 N ATOM 10098 CA ASP C 292 24.695 50.393 −35.197 1.00 79.53 C ATOM 10099 CB ASP C 292 25.105 51.825 −34.693 1.00 83.34 C ATOM 10100 CG ASP C 292 26.644 52.040 −34.538 1.00 84.16 C ATOM 10101 OD1 ASP C 292 27.421 51.787 −35.509 1.00 83.52 O ATOM 10102 OD2 ASP C 292 27.053 52.534 −33.443 1.00 75.96 O ATOM 10103 C ASP C 292 23.252 50.121 −34.744 1.00 79.18 C ATOM 10104 O ASP C 292 23.011 49.793 −33.577 1.00 80.31 O ATOM 10105 N VAL C 293 22.278 50.297 −35.623 1.00 77.77 N ATOM 10106 CA VAL C 293 20.914 50.313 −35.129 1.00 81.77 C ATOM 10107 CB VAL C 293 20.029 51.403 −35.842 1.00 83.33 C ATOM 10108 CG1 VAL C 293 19.145 50.827 −36.967 1.00 77.83 C ATOM 10109 CG2 VAL C 293 19.231 52.200 −34.779 1.00 81.19 C ATOM 10110 C VAL C 293 20.365 48.901 −35.095 1.00 75.02 C ATOM 10111 O VAL C 293 19.539 48.603 −34.237 1.00 76.74 O ATOM 10112 N LEU C 294 20.853 48.039 −35.983 1.00 69.56 N ATOM 10113 CA LEU C 294 20.495 46.626 −35.941 1.00 75.36 C ATOM 10114 CB LEU C 294 20.768 45.947 −37.277 1.00 80.19 C ATOM 10115 CG LEU C 294 20.025 46.395 −38.532 1.00 85.58 C ATOM 10116 CD1 LEU C 294 20.155 45.275 −39.560 1.00 87.90 C ATOM 10117 CD2 LEU C 294 18.563 46.762 −38.290 1.00 88.35 C ATOM 10118 C LEU C 294 21.254 45.869 −34.841 1.00 76.69 C ATOM 10119 O LEU C 294 20.667 45.055 −34.111 1.00 78.02 O ATOM 10120 N ARG C 295 22.564 46.105 −34.747 1.00 70.40 N ATOM 10121 CA ARG C 295 23.344 45.652 −33.607 1.00 63.89 C ATOM 10122 CB ARG C 295 24.600 46.493 −33.472 1.00 67.15 C ATOM 10123 CG ARG C 295 25.859 45.861 −32.910 1.00 65.37 C ATOM 10124 CD ARG C 295 26.391 44.853 −33.902 1.00 70.46 C ATOM 10125 NE ARG C 295 27.795 44.913 −34.293 1.00 67.34 N ATOM 10126 CZ ARG C 295 28.819 45.237 −33.524 1.00 61.84 C ATOM 10127 NH1 ARG C 295 28.680 45.604 −32.251 1.00 56.61 N ATOM 10128 NH2 ARG C 295 30.021 45.188 −34.068 1.00 62.27 N ATOM 10129 C ARG C 295 22.476 45.825 −32.377 1.00 62.29 C ATOM 10130 O ARG C 295 22.274 44.874 −31.661 1.00 73.38 O ATOM 10131 N ILE C 296 21.893 47.001 −32.171 1.00 57.98 N ATOM 10132 CA ILE C 296 21.041 47.211 −31.005 1.00 60.60 C ATOM 10133 CB ILE C 296 20.698 48.702 −30.728 1.00 62.26 C ATOM 10134 CG1 ILE C 296 21.967 49.513 −30.493 1.00 67.75 C ATOM 10135 CD1 ILE C 296 21.764 51.018 −30.585 1.00 71.44 C ATOM 10136 CG2 ILE C 296 19.889 48.860 −29.446 1.00 59.91 C ATOM 10137 C ILE C 296 19.779 46.356 −31.055 1.00 60.96 C ATOM 10138 O ILE C 296 19.389 45.845 −30.026 1.00 64.67 O ATOM 10139 N GLN C 297 19.131 46.198 −32.201 1.00 66.26 N ATOM 10140 CA GLN C 297 17.989 45.264 −32.282 1.00 76.28 C ATOM 10141 CB GLN C 297 17.453 45.018 −33.727 1.00 91.66 C ATOM 10142 CG GLN C 297 16.982 46.205 −34.574 1.00 101.09 C ATOM 10143 CD GLN C 297 15.773 46.916 −34.006 1.00 105.06 C ATOM 10144 OE1 GLN C 297 14.735 46.996 −34.659 1.00 114.20 O ATOM 10145 NE2 GLN C 297 15.907 47.451 −32.794 1.00 97.92 N ATOM 10146 C GLN C 297 18.407 43.906 −31.725 1.00 71.34 C ATOM 10147 O GLN C 297 17.758 43.376 −30.824 1.00 73.11 O ATOM 10148 N LEU C 298 19.484 43.366 −32.288 1.00 65.05 N ATOM 10149 CA LEU C 298 20.041 42.116 −31.871 1.00 63.38 C ATOM 10150 CB LEU C 298 21.364 41.888 −32.547 1.00 62.00 C ATOM 10151 CG LEU C 298 21.386 41.004 −33.752 1.00 63.58 C ATOM 10152 CD1 LEU C 298 22.818 40.503 −33.879 1.00 67.05 C ATOM 10153 CD2 LEU C 298 20.446 39.817 −33.650 1.00 63.80 C ATOM 10154 C LEU C 298 20.310 42.040 −30.392 1.00 66.91 C ATOM 10155 O LEU C 298 19.990 41.055 −29.738 1.00 78.15 O ATOM 10156 N LEU C 299 20.950 43.059 −29.865 1.00 67.09 N ATOM 10157 CA LEU C 299 21.248 43.100 −28.428 1.00 68.52 C ATOM 10158 CB LEU C 299 22.054 44.351 −28.111 1.00 68.12 C ATOM 10159 CG LEU C 299 23.556 44.141 −28.065 1.00 71.12 C ATOM 10160 CD1 LEU C 299 23.909 44.005 −26.594 1.00 80.41 C ATOM 10161 CD2 LEU C 299 24.079 42.944 −28.860 1.00 72.31 C ATOM 10162 C LEU C 299 20.024 43.060 −27.545 1.00 67.34 C ATOM 10163 O LEU C 299 20.000 42.361 −26.528 1.00 65.26 O ATOM 10164 N LYS C 300 19.020 43.820 −27.950 1.00 69.80 N ATOM 10165 CA LYS C 300 17.825 43.956 −27.168 1.00 75.00 C ATOM 10166 CB LYS C 300 16.977 45.142 −27.666 1.00 75.53 C ATOM 10167 CG LYS C 300 17.520 46.512 −27.239 1.00 75.88 C ATOM 10168 CD LYS C 300 16.409 47.481 −26.845 1.00 80.67 C ATOM 10169 CE LYS C 300 16.765 48.918 −27.216 1.00 87.48 C ATOM 10170 NZ LYS C 300 15.673 49.894 −26.931 1.00 90.31 N ATOM 10171 C LYS C 300 17.057 42.617 −27.060 1.00 77.49 C ATOM 10172 O LYS C 300 16.665 42.228 −25.948 1.00 77.84 O ATOM 10173 N ILE C 301 16.890 41.909 −28.185 1.00 78.10 N ATOM 10174 CA ILE C 301 16.444 40.478 −28.216 1.00 74.29 C ATOM 10175 CB ILE C 301 16.696 39.876 −29.635 1.00 74.47 C ATOM 10176 CG1 ILE C 301 15.442 40.047 −30.502 1.00 80.31 C ATOM 10177 CD1 ILE C 301 15.680 39.951 −32.014 1.00 85.92 C ATOM 10178 CG2 ILE C 301 17.158 38.426 −29.617 1.00 72.23 C ATOM 10179 C ILE C 301 17.123 39.669 −27.098 1.00 71.81 C ATOM 10180 O ILE C 301 18.351 39.547 −27.044 1.00 70.60 O ATOM 10181 N GLY C 302 16.317 39.177 −26.171 1.00 73.23 N ATOM 10182 CA GLY C 302 16.850 38.595 −24.917 1.00 76.32 C ATOM 10183 C GLY C 302 17.048 37.092 −24.995 1.00 76.44 C ATOM 10184 O GLY C 302 17.978 36.515 −24.328 1.00 66.11 O ATOM 10185 N SER C 303 16.155 36.501 −25.821 1.00 71.52 N ATOM 10186 CA SER C 303 16.111 35.075 −26.163 1.00 64.18 C ATOM 10187 CB SER C 303 14.727 34.768 −26.733 1.00 67.60 C ATOM 10188 OG SER C 303 14.811 34.087 −27.969 1.00 68.29 O ATOM 10189 C SER C 303 17.127 34.677 −27.212 1.00 54.90 C ATOM 10190 O SER C 303 17.083 35.208 −28.308 1.00 50.27 O ATOM 10191 N ALA C 304 18.000 33.717 −26.928 1.00 48.26 N ATOM 10192 CA ALA C 304 18.993 33.316 −27.946 1.00 47.96 C ATOM 10193 CB ALA C 304 20.059 32.408 −27.353 1.00 47.70 C ATOM 10194 C ALA C 304 18.403 32.682 −29.215 1.00 47.54 C ATOM 10195 O ALA C 304 18.925 32.815 −30.281 1.00 45.52 O ATOM 10196 N ILE C 305 17.303 31.991 −29.093 1.00 49.44 N ATOM 10197 CA ILE C 305 16.698 31.398 −30.254 1.00 51.24 C ATOM 10198 CB ILE C 305 15.475 30.520 −29.864 1.00 52.26 C ATOM 10199 CG1 ILE C 305 15.883 29.378 −28.954 1.00 49.68 C ATOM 10200 CD1 ILE C 305 16.839 28.429 −29.617 1.00 51.01 C ATOM 10201 CG2 ILE C 305 14.754 29.946 −31.091 1.00 53.19 C ATOM 10202 C ILE C 305 16.289 32.481 −31.248 1.00 50.62 C ATOM 10203 O ILE C 305 16.508 32.333 −32.452 1.00 51.27 O ATOM 10204 N GLN C 306 15.683 33.556 −30.775 1.00 53.33 N ATOM 10205 CA GLN C 306 15.315 34.651 −31.702 1.00 58.97 C ATOM 10206 CB GLN C 306 14.385 35.681 −31.052 1.00 60.03 C ATOM 10207 CG GLN C 306 12.981 35.128 −30.879 1.00 64.60 C ATOM 10208 CD GLN C 306 12.151 35.853 −29.829 1.00 70.01 C ATOM 10209 OE1 GLN C 306 12.678 36.504 −28.920 1.00 72.00 O ATOM 10210 NE2 GLN C 306 10.830 35.730 −29.945 1.00 74.80 N ATOM 10211 C GLN C 306 16.552 35.332 −32.285 1.00 59.15 C ATOM 10212 O GLN C 306 16.510 35.740 −33.447 1.00 67.07 O ATOM 10213 N ARG C 307 17.631 35.423 −31.487 1.00 54.03 N ATOM 10214 CA ARG C 307 18.909 35.997 −31.916 1.00 50.35 C ATOM 10215 CB ARG C 307 19.911 36.083 −30.744 1.00 52.19 C ATOM 10216 CG ARG C 307 20.737 37.364 −30.723 1.00 54.21 C ATOM 10217 CD ARG C 307 21.639 37.538 −29.490 1.00 56.93 C ATOM 10218 NE ARG C 307 20.886 37.812 −28.263 1.00 55.51 N ATOM 10219 CZ ARG C 307 20.867 37.024 −27.186 1.00 59.80 C ATOM 10220 NH1 ARG C 307 21.604 35.920 −27.114 1.00 60.19 N ATOM 10221 NH2 ARG C 307 20.110 37.340 −26.135 1.00 64.72 N ATOM 10222 C ARG C 307 19.515 35.213 −33.079 1.00 48.56 C ATOM 10223 O ARG C 307 19.938 35.798 −34.055 1.00 53.19 O ATOM 10224 N LEU C 308 19.519 33.889 −32.974 1.00 48.13 N ATOM 10225 CA LEU C 308 20.055 32.985 −33.982 1.00 44.96 C ATOM 10226 CB LEU C 308 20.048 31.558 −33.475 1.00 42.71 C ATOM 10227 CG LEU C 308 20.922 31.384 −32.262 1.00 44.92 C ATOM 10228 CD1 LEU C 308 20.440 30.284 −31.331 1.00 45.43 C ATOM 10229 CD2 LEU C 308 22.330 31.114 −32.712 1.00 46.01 C ATOM 10230 C LEU C 308 19.218 33.048 −35.250 1.00 46.74 C ATOM 10231 O LEU C 308 19.727 32.921 −36.349 1.00 48.62 O ATOM 10232 N ARG C 309 17.924 33.221 −35.132 1.00 49.44 N ATOM 10233 CA ARG C 309 17.120 33.240 −36.355 1.00 55.02 C ATOM 10234 CB ARG C 309 15.665 33.058 −36.028 1.00 52.02 C ATOM 10235 CG ARG C 309 15.433 31.688 −35.490 1.00 52.07 C ATOM 10236 CD ARG C 309 14.143 31.739 −34.776 1.00 54.64 C ATOM 10237 NE ARG C 309 13.151 32.319 −35.656 1.00 51.99 N ATOM 10238 CZ ARG C 309 12.554 31.653 −36.606 1.00 51.06 C ATOM 10239 NH1 ARG C 309 11.646 32.254 −37.327 1.00 53.49 N ATOM 10240 NH2 ARG C 309 12.833 30.378 −36.819 1.00 53.82 N ATOM 10241 C ARG C 309 17.310 34.539 −37.109 1.00 57.69 C ATOM 10242 O ARG C 309 17.397 34.579 −38.349 1.00 61.67 O ATOM 10243 N CYS C 310 17.325 35.591 −36.323 1.00 57.45 N ATOM 10244 CA CYS C 310 17.594 36.885 −36.795 1.00 59.70 C ATOM 10245 CB CYS C 310 17.414 37.870 −35.636 1.00 63.19 C ATOM 10246 SG CYS C 310 17.885 39.467 −36.223 1.00 76.75 S ATOM 10247 C CYS C 310 19.005 36.924 −37.420 1.00 56.48 C ATOM 10248 O CYS C 310 19.221 37.573 −38.436 1.00 58.02 O ATOM 10249 N GLU C 311 19.968 36.227 −36.849 1.00 53.51 N ATOM 10250 CA GLU C 311 21.293 36.207 −37.471 1.00 54.87 C ATOM 10251 CB GLU C 311 22.328 35.714 −36.483 1.00 53.70 C ATOM 10252 CG GLU C 311 22.636 36.701 −35.376 1.00 51.83 C ATOM 10253 CD GLU C 311 23.218 36.013 −34.156 1.00 54.27 C ATOM 10254 OE1 GLU C 311 23.628 36.730 −33.230 1.00 53.49 O ATOM 10255 OE2 GLU C 311 23.285 34.750 −34.120 1.00 55.88 O ATOM 10256 C GLU C 311 21.356 35.364 −38.759 1.00 56.18 C ATOM 10257 O GLU C 311 22.173 35.591 −39.616 1.00 55.15 O ATOM 10258 N LEU C 312 20.518 34.348 −38.860 1.00 61.05 N ATOM 10259 CA LEU C 312 20.391 33.592 −40.091 1.00 57.42 C ATOM 10260 CB LEU C 312 19.529 32.357 −39.913 1.00 56.61 C ATOM 10261 CG LEU C 312 20.329 31.125 −39.530 1.00 59.86 C ATOM 10262 CD1 LEU C 312 19.359 29.971 −39.312 1.00 65.67 C ATOM 10263 CD2 LEU C 312 21.336 30.744 −40.601 1.00 61.02 C ATOM 10264 C LEU C 312 19.802 34.467 −41.136 1.00 55.75 C ATOM 10265 O LEU C 312 20.289 34.481 −42.240 1.00 58.67 O ATOM 10266 N ASP C 313 18.764 35.208 −40.788 1.00 55.33 N ATOM 10267 CA ASP C 313 18.127 36.089 −41.746 1.00 58.16 C ATOM 10268 CB ASP C 313 16.962 36.850 −41.117 1.00 62.68 C ATOM 10269 CG ASP C 313 15.932 37.266 −42.129 1.00 73.12 C ATOM 10270 OD1 ASP C 313 15.233 36.348 −42.603 1.00 83.27 O ATOM 10271 OD2 ASP C 313 15.801 38.484 −42.454 1.00 84.53 O ATOM 10272 C ASP C 313 19.178 37.050 −42.306 1.00 56.77 C ATOM 10273 O ASP C 313 19.445 37.042 −43.500 1.00 54.82 O ATOM 10274 N ILE C 314 19.843 37.797 −41.429 1.00 57.88 N ATOM 10275 CA ILE C 314 20.811 38.817 −41.841 1.00 56.63 C ATOM 10276 CB ILE C 314 21.551 39.446 −40.631 1.00 57.04 C ATOM 10277 CG1 ILE C 314 20.604 40.290 −39.758 1.00 57.36 C ATOM 10278 CD1 ILE C 314 20.926 40.214 −38.261 1.00 55.70 C ATOM 10279 CG2 ILE C 314 22.689 40.341 −41.075 1.00 54.93 C ATOM 10280 C ILE C 314 21.792 38.148 −42.790 1.00 55.40 C ATOM 10281 O ILE C 314 21.982 38.592 −43.914 1.00 55.07 O ATOM 10282 N MET C 315 22.362 37.039 −42.375 1.00 54.51 N ATOM 10283 CA MET C 315 23.300 36.366 −43.241 1.00 58.70 C ATOM 10284 CB MET C 315 23.955 35.160 −42.560 1.00 62.59 C ATOM 10285 CG MET C 315 24.873 35.419 −41.368 1.00 62.93 C ATOM 10286 SD MET C 315 25.016 33.818 −40.520 1.00 66.58 S ATOM 10287 CE MET C 315 26.783 33.747 −40.301 1.00 72.97 C ATOM 10288 C MET C 315 22.736 35.918 −44.602 1.00 58.77 C ATOM 10289 O MET C 315 23.509 35.828 −45.549 1.00 66.41 O ATOM 10290 N ASN C 316 21.457 35.589 −44.739 1.00 57.58 N ATOM 10291 CA ASN C 316 20.998 35.088 −46.055 1.00 60.47 C ATOM 10292 CB ASN C 316 19.882 34.044 −45.969 1.00 61.87 C ATOM 10293 CG ASN C 316 20.274 32.830 −45.127 1.00 65.73 C ATOM 10294 OD1 ASN C 316 21.372 32.291 −45.240 1.00 70.27 O ATOM 10295 ND2 ASN C 316 19.380 32.417 −44.250 1.00 68.04 N ATOM 10296 C ASN C 316 20.595 36.243 −46.943 1.00 64.77 C ATOM 10297 O ASN C 316 21.055 36.317 −48.095 1.00 70.91 O ATOM 10298 N LYS C 317 19.776 37.153 −46.397 1.00 65.68 N ATOM 10299 CA LYS C 317 19.275 38.339 −47.119 1.00 63.55 C ATOM 10300 CB LYS C 317 18.124 39.015 −46.322 1.00 56.69 C ATOM 10301 C LYS C 317 20.424 39.319 −47.517 1.00 67.89 C ATOM 10302 O LYS C 317 20.637 39.563 −48.679 1.00 66.62 O ATOM 10303 N CYS C 318 21.196 39.826 −46.565 1.00 82.04 N ATOM 10304 CA CYS C 318 22.182 40.913 −46.827 1.00 89.35 C ATOM 10305 CB CYS C 318 22.633 41.587 −45.496 1.00 94.63 C ATOM 10306 SG CYS C 318 21.297 42.266 −44.429 1.00 93.58 S ATOM 10307 C CYS C 318 23.410 40.407 −47.580 1.00 86.84 C ATOM 10308 O CYS C 318 24.188 39.636 −47.031 1.00 92.06 O ATOM 10309 N THR C 319 23.600 40.875 −48.812 1.00 87.09 N ATOM 10310 CA THR C 319 24.667 40.357 −49.710 1.00 83.63 C ATOM 10311 CB THR C 319 24.019 39.623 −50.866 1.00 85.73 C ATOM 10312 OG1 THR C 319 23.012 40.480 −51.423 1.00 81.93 O ATOM 10313 CG2 THR C 319 23.416 38.308 −50.340 1.00 89.50 C ATOM 10314 C THR C 319 25.698 41.333 −50.330 1.00 75.50 C ATOM 10315 O THR C 319 26.768 40.882 −50.741 1.00 73.31 O ATOM 10316 N SER C 320 25.371 42.624 −50.444 1.00 68.15 N ATOM 10317 CA SER C 320 26.339 43.657 −50.841 1.00 64.38 C ATOM 10318 CB SER C 320 25.769 44.617 −51.920 1.00 63.68 C ATOM 10319 OG SER C 320 24.964 45.668 −51.375 1.00 63.30 O ATOM 10320 C SER C 320 26.681 44.426 −49.601 1.00 63.33 C ATOM 10321 O SER C 320 26.015 44.299 −48.593 1.00 72.63 O ATOM 10322 N LEU C 321 27.721 45.231 −49.684 1.00 59.64 N ATOM 10323 CA LEU C 321 28.085 46.149 −48.635 1.00 55.79 C ATOM 10324 CB LEU C 321 29.228 45.538 −47.824 1.00 56.93 C ATOM 10325 CG LEU C 321 28.885 44.397 −46.870 1.00 54.06 C ATOM 10326 CD1 LEU C 321 30.057 43.522 −46.520 1.00 54.92 C ATOM 10327 CD2 LEU C 321 28.351 45.004 −45.615 1.00 53.62 C ATOM 10328 C LEU C 321 28.561 47.386 −49.352 1.00 54.79 C ATOM 10329 O LEU C 321 29.326 47.278 −50.297 1.00 52.31 O ATOM 10330 N CYS C 322 28.100 48.551 −48.917 1.00 56.71 N ATOM 10331 CA CYS C 322 28.351 49.836 −49.595 1.00 56.03 C ATOM 10332 CB CYS C 322 27.068 50.341 −50.209 1.00 57.76 C ATOM 10333 SG CYS C 322 26.318 49.035 −51.187 1.00 70.46 S ATOM 10334 C CYS C 322 28.859 50.897 −48.644 1.00 55.51 C ATOM 10335 O CYS C 322 28.942 50.721 −47.442 1.00 55.55 O ATOM 10336 N CYS C 323 29.229 52.013 −49.225 1.00 54.06 N ATOM 10337 CA CYS C 323 29.794 53.108 −48.502 1.00 51.54 C ATOM 10338 CB CYS C 323 30.462 54.027 −49.518 1.00 50.83 C ATOM 10339 SG CYS C 323 30.870 55.680 −48.977 1.00 48.55 S ATOM 10340 C CYS C 323 28.624 53.750 −47.796 1.00 54.01 C ATOM 10341 O CYS C 323 27.647 54.047 −48.422 1.00 55.68 O ATOM 10342 N LYS C 324 28.697 53.910 −46.480 1.00 59.33 N ATOM 10343 CA LYS C 324 27.598 54.498 −45.714 1.00 58.51 C ATOM 10344 CB LYS C 324 27.922 54.566 −44.226 1.00 61.62 C ATOM 10345 CG LYS C 324 26.750 54.817 −43.270 1.00 67.51 C ATOM 10346 CD LYS C 324 27.143 54.470 −41.816 1.00 72.37 C ATOM 10347 CE LYS C 324 26.248 55.064 −40.715 1.00 79.29 C ATOM 10348 NZ LYS C 324 25.222 54.154 −40.084 1.00 80.93 N ATOM 10349 C LYS C 324 27.288 55.877 −46.244 1.00 59.16 C ATOM 10350 O LYS C 324 26.134 56.205 −46.375 1.00 66.75 O ATOM 10351 N GLN C 325 28.313 56.714 −46.401 1.00 59.17 N ATOM 10352 CA GLN C 325 28.109 58.096 −46.839 1.00 62.07 C ATOM 10353 CB GLN C 325 29.394 58.905 −46.629 1.00 66.88 C ATOM 10354 CG GLN C 325 29.287 60.360 −47.053 1.00 74.67 C ATOM 10355 CD GLN C 325 28.213 61.112 −46.291 1.00 84.94 C ATOM 10356 OE1 GLN C 325 27.534 60.547 −45.433 1.00 91.35 O ATOM 10357 NE2 GLN C 325 28.054 62.393 −46.601 1.00 91.02 N ATOM 10358 C GLN C 325 27.595 58.320 −48.258 1.00 62.10 C ATOM 10359 O GLN C 325 26.664 59.099 −48.464 1.00 60.70 O ATOM 10360 N CYS C 326 28.191 57.645 −49.235 1.00 67.47 N ATOM 10361 CA CYS C 326 27.742 57.810 −50.609 1.00 60.32 C ATOM 10362 CB CYS C 326 28.695 57.105 −51.575 1.00 51.56 C ATOM 10363 SG CYS C 326 30.396 57.715 −51.524 1.00 47.70 S ATOM 10364 C CYS C 326 26.342 57.245 −50.747 1.00 64.60 C ATOM 10365 O CYS C 326 25.457 57.845 −51.357 1.00 70.48 O ATOM 10366 N GLN C 327 26.169 56.067 −50.161 1.00 66.87 N ATOM 10367 CA GLN C 327 24.908 55.348 −50.172 1.00 75.33 C ATOM 10368 CB GLN C 327 23.737 56.306 −49.947 1.00 80.37 C ATOM 10369 CG GLN C 327 22.375 55.632 −49.946 1.00 85.62 C ATOM 10370 CD GLN C 327 22.244 54.582 −48.861 1.00 89.48 C ATOM 10371 OE1 GLN C 327 23.177 54.347 −48.093 1.00 91.97 O ATOM 10372 NE2 GLN C 327 21.081 53.944 −48.792 1.00 89.03 N ATOM 10373 C GLN C 327 24.754 54.630 −51.508 1.00 76.75 C ATOM 10374 O GLN C 327 23.794 53.888 −51.716 1.00 81.01 O ATOM 10375 N GLU C 328 25.704 54.855 −52.413 1.00 74.61 N ATOM 10376 CA GLU C 328 25.653 54.223 −53.726 1.00 81.84 C ATOM 10377 CB GLU C 328 24.809 55.070 −54.685 1.00 98.99 C ATOM 10378 CG GLU C 328 23.370 55.267 −54.237 1.00 105.83 C ATOM 10379 CD GLU C 328 22.567 56.108 −55.210 1.00 111.97 C ATOM 10380 OE1 GLU C 328 21.368 56.340 −54.948 1.00 110.95 O ATOM 10381 OE2 GLU C 328 23.135 56.538 −56.236 1.00 107.47 O ATOM 10382 C GLU C 328 27.001 53.890 −54.376 1.00 79.02 C ATOM 10383 O GLU C 328 27.347 54.476 −55.403 1.00 72.82 O ATOM 10384 N THR C 329 27.756 52.952 −53.813 1.00 71.09 N ATOM 10385 CA THR C 329 28.986 52.879 −54.427 1.00 68.53 C ATOM 10386 CB THR C 329 30.068 53.481 −53.916 1.00 68.77 C ATOM 10387 OG1 THR C 329 29.583 54.816 −54.017 1.00 79.34 O ATOM 10388 CG2 THR C 329 31.301 53.337 −54.734 1.00 62.51 C ATOM 10389 C THR C 329 29.107 51.254 −53.796 1.00 69.82 C ATOM 10390 O THR C 329 28.999 51.178 −52.590 1.00 69.34 O ATOM 10391 N GLU C 330 29.338 50.208 −54.568 1.00 66.54 N ATOM 10392 CA GLU C 330 29.418 48.907 −53.966 1.00 66.32 C ATOM 10393 CB GLU C 330 28.867 47.866 −54.908 1.00 73.03 C ATOM 10394 CG GLU C 330 28.281 46.673 −54.203 1.00 81.79 C ATOM 10395 CD GLU C 330 28.349 45.421 −55.028 1.00 85.68 C ATOM 10396 OE1 GLU C 330 27.332 44.725 −55.103 1.00 90.09 O ATOM 10397 OE2 GLU C 330 29.412 45.130 −55.603 1.00 81.79 O ATOM 10398 C GLU C 330 30.826 48.586 −53.659 1.00 65.24 C ATOM 10399 O GLU C 330 31.603 48.335 −54.546 1.00 69.17 O ATOM 10400 N ILE C 331 31.144 48.575 −52.379 1.00 65.56 N ATOM 10401 CA ILE C 331 32.514 48.240 −51.907 1.00 62.03 C ATOM 10402 CB ILE C 331 32.842 48.755 −50.477 1.00 63.25 C ATOM 10403 CG1 ILE C 331 32.439 50.219 −50.261 1.00 64.10 C ATOM 10404 CD1 ILE C 331 32.996 51.202 −51.252 1.00 65.71 C ATOM 10405 CG2 ILE C 331 34.332 48.620 −50.168 1.00 64.58 C ATOM 10406 C ILE C 331 32.816 46.729 −51.984 1.00 56.99 C ATOM 10407 O ILE C 331 33.879 46.384 −52.417 1.00 54.02 O ATOM 10408 N THR C 332 31.908 45.846 −51.574 1.00 57.20 N ATOM 10409 CA THR C 332 32.144 44.386 −51.691 1.00 59.62 C ATOM 10410 CB THR C 332 33.243 43.902 −50.700 1.00 60.14 C ATOM 10411 OG1 THR C 332 33.612 42.542 −50.998 1.00 59.59 O ATOM 10412 CG2 THR C 332 32.767 44.025 −49.235 1.00 58.65 C ATOM 10413 C THR C 332 30.874 43.501 −51.529 1.00 60.48 C ATOM 10414 O THR C 332 29.762 44.023 −51.344 1.00 62.74 O ATOM 10415 N THR C 333 31.063 42.173 −51.603 1.00 58.28 N ATOM 10416 CA THR C 333 29.978 41.200 −51.442 1.00 60.59 C ATOM 10417 CB THR C 333 29.702 40.461 −52.771 1.00 65.84 C ATOM 10418 OG1 THR C 333 30.677 39.421 −52.985 1.00 74.56 O ATOM 10419 CG2 THR C 333 29.756 41.433 −53.955 1.00 65.30 C ATOM 10420 C THR C 333 30.260 40.168 −50.334 1.00 56.23 C ATOM 10421 O THR C 333 31.396 39.926 −49.979 1.00 50.53 O ATOM 10422 N LYS C 334 29.195 39.571 −49.813 1.00 57.17 N ATOM 10423 CA LYS C 334 29.249 38.412 −48.914 1.00 59.65 C ATOM 10424 CB LYS C 334 27.833 37.817 −48.717 1.00 67.92 C ATOM 10425 CG LYS C 334 27.717 36.429 −48.029 1.00 77.63 C ATOM 10426 CD LYS C 334 26.333 35.769 −48.250 1.00 81.26 C ATOM 10427 CE LYS C 334 26.332 34.253 −48.022 1.00 82.21 C ATOM 10428 NZ LYS C 334 25.922 33.859 −46.643 1.00 85.96 N ATOM 10429 C LYS C 334 30.178 37.336 −49.442 1.00 56.11 C ATOM 10430 O LYS C 334 30.890 36.698 −48.659 1.00 51.96 O ATOM 10431 N ASN C 335 30.174 37.120 −50.757 1.00 56.08 N ATOM 10432 CA ASN C 335 31.061 36.115 −51.351 1.00 59.70 C ATOM 10433 CB ASN C 335 31.032 36.205 −52.876 1.00 70.75 C ATOM 10434 CG ASN C 335 30.055 35.254 −53.511 1.00 76.17 C ATOM 10435 OD1 ASN C 335 30.030 35.130 −54.743 1.00 87.29 O ATOM 10436 ND2 ASN C 335 29.256 34.568 −52.699 1.00 72.75 N ATOM 10437 C ASN C 335 32.509 36.237 −50.937 1.00 57.14 C ATOM 10438 O ASN C 335 33.236 35.263 −50.970 1.00 55.63 O ATOM 10439 N GLU C 336 32.919 37.461 −50.609 1.00 57.34 N ATOM 10440 CA GLU C 336 34.298 37.812 −50.398 1.00 55.23 C ATOM 10441 CB GLU C 336 34.585 39.218 −50.961 1.00 60.72 C ATOM 10442 CG GLU C 336 34.213 39.457 −52.433 1.00 66.27 C ATOM 10443 CD GLU C 336 34.834 38.449 −53.424 1.00 74.85 C ATOM 10444 OE1 GLU C 336 34.182 38.205 −54.478 1.00 84.59 O ATOM 10445 OE2 GLU C 336 35.946 37.891 −53.167 1.00 75.15 O ATOM 10446 C GLU C 336 34.648 37.784 −48.951 1.00 50.33 C ATOM 10447 O GLU C 336 35.801 37.682 −48.625 1.00 51.45 O ATOM 10448 N ILE C 337 33.681 37.882 −48.054 1.00 48.79 N ATOM 10449 CA ILE C 337 34.000 37.883 −46.625 1.00 48.12 C ATOM 10450 CB ILE C 337 32.735 37.959 −45.771 1.00 46.70 C ATOM 10451 CG1 ILE C 337 32.202 39.393 −45.785 1.00 46.46 C ATOM 10452 CD1 ILE C 337 30.765 39.529 −45.281 1.00 47.54 C ATOM 10453 CG2 ILE C 337 33.001 37.523 −44.341 1.00 46.62 C ATOM 10454 C ILE C 337 34.746 36.632 −46.280 1.00 49.17 C ATOM 10455 O ILE C 337 34.407 35.586 −46.800 1.00 55.79 O ATOM 10456 N PHE C 338 35.751 36.735 −45.419 1.00 50.59 N ATOM 10457 CA PHE C 338 36.488 35.554 −44.954 1.00 54.39 C ATOM 10458 CB PHE C 338 37.473 35.069 −46.027 1.00 55.70 C ATOM 10459 CG PHE C 338 38.771 35.807 −46.035 1.00 55.30 C ATOM 10460 CD1 PHE C 338 38.802 37.175 −46.250 1.00 56.42 C ATOM 10461 CE1 PHE C 338 40.006 37.856 −46.264 1.00 59.84 C ATOM 10462 CZ PHE C 338 41.205 37.167 −46.060 1.00 61.18 C ATOM 10463 CE2 PHE C 338 41.176 35.803 −45.858 1.00 60.88 C ATOM 10464 CD2 PHE C 338 39.958 35.134 −45.829 1.00 57.73 C ATOM 10465 C PHE C 338 37.230 35.834 −43.664 1.00 54.00 C ATOM 10466 O PHE C 338 37.440 37.007 −43.334 1.00 51.54 O ATOM 10467 N SER C 339 37.653 34.771 −42.968 1.00 54.52 N ATOM 10468 CA SER C 339 38.244 34.915 −41.629 1.00 58.90 C ATOM 10469 CB SER C 339 37.536 34.032 −40.625 1.00 55.95 C ATOM 10470 OG SER C 339 36.203 34.454 −40.497 1.00 56.64 O ATOM 10471 C SER C 339 39.741 34.667 −41.521 1.00 65.07 C ATOM 10472 O SER C 339 40.219 33.555 −41.840 1.00 64.88 O ATOM 10473 N LEU C 340 40.442 35.731 −41.069 1.00 70.38 N ATOM 10474 CA LEU C 340 41.804 35.673 −40.519 1.00 70.00 C ATOM 10475 CB LEU C 340 42.650 36.852 −40.979 1.00 69.34 C ATOM 10476 CG LEU C 340 42.864 36.955 −42.470 1.00 70.59 C ATOM 10477 CD1 LEU C 340 43.730 38.175 −42.718 1.00 73.21 C ATOM 10478 CD2 LEU C 340 43.529 35.709 −43.001 1.00 69.77 C ATOM 10479 C LEU C 340 41.879 35.681 −39.008 1.00 71.69 C ATOM 10480 O LEU C 340 42.927 35.358 −38.500 1.00 81.40 O ATOM 10481 N SER C 341 40.838 36.101 −38.281 1.00 72.91 N ATOM 10482 CA SER C 341 40.843 35.997 −36.798 1.00 68.51 C ATOM 10483 CB SER C 341 40.135 37.189 −36.084 1.00 72.22 C ATOM 10484 OG SER C 341 40.695 37.558 −34.798 1.00 73.99 O ATOM 10485 C SER C 341 40.138 34.732 −36.444 1.00 64.76 C ATOM 10486 O SER C 341 39.111 34.387 −36.993 1.00 63.85 O ATOM 10487 N LEU C 342 40.673 34.055 −35.471 1.00 69.05 N ATOM 10488 CA LEU C 342 39.899 33.061 −34.768 1.00 70.23 C ATOM 10489 CB LEU C 342 40.666 32.602 −33.556 1.00 71.53 C ATOM 10490 CG LEU C 342 40.650 31.110 −33.509 1.00 73.64 C ATOM 10491 CD1 LEU C 342 41.929 30.629 −34.183 1.00 71.07 C ATOM 10492 CD2 LEU C 342 40.492 30.693 −32.040 1.00 81.16 C ATOM 10493 C LEU C 342 38.563 33.593 −34.277 1.00 69.11 C ATOM 10494 O LEU C 342 37.595 32.853 −34.213 1.00 73.46 O ATOM 10495 N CYS C 343 38.535 34.861 −33.873 1.00 71.08 N ATOM 10496 CA CYS C 343 37.282 35.559 −33.562 1.00 73.25 C ATOM 10497 CB CYS C 343 37.560 36.996 −33.117 1.00 76.24 C ATOM 10498 SG CYS C 343 38.451 37.112 −31.555 1.00 80.48 S ATOM 10499 C CYS C 343 36.236 35.585 −34.700 1.00 69.09 C ATOM 10500 O CYS C 343 35.033 35.615 −34.424 1.00 71.64 O ATOM 10501 N GLY C 344 36.683 35.579 −35.955 1.00 63.38 N ATOM 10502 CA GLY C 344 35.786 35.683 −37.094 1.00 59.70 C ATOM 10503 C GLY C 344 36.228 36.616 −38.208 1.00 59.05 C ATOM 10504 O GLY C 344 37.373 37.082 −38.245 1.00 60.80 O ATOM 10505 N PRO C 345 35.304 36.900 −39.146 1.00 59.03 N ATOM 10506 CA PRO C 345 35.638 37.805 −40.219 1.00 58.21 C ATOM 10507 CB PRO C 345 34.483 37.616 −41.200 1.00 57.49 C ATOM 10508 CG PRO C 345 33.326 37.282 −40.350 1.00 56.10 C ATOM 10509 CD PRO C 345 33.917 36.414 −39.286 1.00 58.21 C ATOM 10510 C PRO C 345 35.703 39.232 −39.772 1.00 57.19 C ATOM 10511 O PRO C 345 36.255 40.016 −40.491 1.00 61.52 O ATOM 10512 N MET C 346 35.158 39.580 −38.613 1.00 56.75 N ATOM 10513 CA MET C 346 35.249 40.954 −38.164 1.00 58.62 C ATOM 10514 CB MET C 346 33.973 41.709 −38.555 1.00 56.79 C ATOM 10515 CG MET C 346 33.845 43.090 −37.942 1.00 55.24 C ATOM 10516 SD MET C 346 32.414 43.986 −38.521 1.00 53.69 S ATOM 10517 CE MET C 346 31.185 43.396 −37.384 1.00 56.80 C ATOM 10518 C MET C 346 35.526 41.017 −36.663 1.00 60.33 C ATOM 10519 O MET C 346 35.159 40.102 −35.921 1.00 66.43 O ATOM 10520 N ALA C 347 36.177 42.111 −36.251 1.00 56.90 N ATOM 10521 CA ALA C 347 36.733 42.280 −34.924 1.00 51.86 C ATOM 10522 CB ALA C 347 37.841 41.285 −34.701 1.00 50.85 C ATOM 10523 C ALA C 347 37.287 43.675 −34.725 1.00 51.42 C ATOM 10524 O ALA C 347 37.660 44.353 −35.665 1.00 55.87 O ATOM 10525 N ALA C 348 37.392 44.046 −33.462 1.00 53.28 N ATOM 10526 CA ALA C 348 37.738 45.384 −33.005 1.00 51.74 C ATOM 10527 CB ALA C 348 36.941 45.702 −31.724 1.00 51.30 C ATOM 10528 C ALA C 348 39.248 45.473 −32.748 1.00 50.15 C ATOM 10529 O ALA C 348 39.797 44.586 −32.117 1.00 55.65 O ATOM 10530 N TYR C 349 39.887 46.522 −33.268 1.00 49.77 N ATOM 10531 CA TYR C 349 41.317 46.811 −33.122 1.00 50.32 C ATOM 10532 CB TYR C 349 42.057 46.545 −34.437 1.00 51.01 C ATOM 10533 CG TYR C 349 41.897 45.111 −34.942 1.00 52.09 C ATOM 10534 CD1 TYR C 349 42.511 44.043 −34.304 1.00 52.62 C ATOM 10535 CE1 TYR C 349 42.357 42.734 −34.752 1.00 52.46 C ATOM 10536 CZ TYR C 349 41.565 42.464 −35.842 1.00 53.79 C ATOM 10537 OH TYR C 349 41.390 41.159 −36.317 1.00 54.92 O ATOM 10538 CE2 TYR C 349 40.940 43.520 −36.475 1.00 55.71 C ATOM 10539 CD2 TYR C 349 41.114 44.824 −36.024 1.00 52.80 C ATOM 10540 C TYR C 349 41.434 48.284 −32.767 1.00 50.39 C ATOM 10541 O TYR C 349 40.567 49.058 −33.149 1.00 48.88 O ATOM 10542 N VAL C 350 42.456 48.679 −32.011 1.00 51.23 N ATOM 10543 CA VAL C 350 42.636 50.110 −31.752 1.00 54.36 C ATOM 10544 CB VAL C 350 42.928 50.545 −30.301 1.00 54.87 C ATOM 10545 CG1 VAL C 350 41.633 50.924 −29.646 1.00 59.12 C ATOM 10546 CG2 VAL C 350 43.634 49.495 −29.493 1.00 53.81 C ATOM 10547 C VAL C 350 43.754 50.588 −32.582 1.00 56.42 C ATOM 10548 O VAL C 350 44.716 49.838 −32.831 1.00 57.45 O ATOM 10549 N ASN C 351 43.647 51.847 −32.983 1.00 52.82 N ATOM 10550 CA ASN C 351 44.725 52.436 −33.724 1.00 54.22 C ATOM 10551 CB ASN C 351 44.168 53.298 −34.861 1.00 55.67 C ATOM 10552 CG ASN C 351 43.786 54.681 −34.440 1.00 54.78 C ATOM 10553 OD1 ASN C 351 43.720 55.014 −33.255 1.00 56.66 O ATOM 10554 ND2 ASN C 351 43.510 55.503 −35.424 1.00 54.50 N ATOM 10555 C ASN C 351 45.647 53.158 −32.762 1.00 54.94 C ATOM 10556 O ASN C 351 45.445 53.104 −31.523 1.00 56.91 O ATOM 10557 N PRO C 352 46.660 53.836 −33.304 1.00 53.49 N ATOM 10558 CA PRO C 352 47.627 54.461 −32.432 1.00 54.74 C ATOM 10559 CB PRO C 352 48.591 55.074 −33.411 1.00 52.95 C ATOM 10560 CG PRO C 352 48.578 54.117 −34.531 1.00 52.55 C ATOM 10561 CD PRO C 352 47.127 53.860 −34.693 1.00 52.81 C ATOM 10562 C PRO C 352 47.072 55.531 −31.500 1.00 56.94 C ATOM 10563 O PRO C 352 47.627 55.733 −30.400 1.00 58.56 O ATOM 10564 N HIS C 353 46.000 56.192 −31.936 1.00 56.29 N ATOM 10565 CA HIS C 353 45.422 57.295 −31.189 1.00 59.20 C ATOM 10566 CB HIS C 353 44.963 58.390 −32.160 1.00 60.73 C ATOM 10567 CG HIS C 353 46.078 58.932 −33.009 1.00 64.95 C ATOM 10568 ND1 HIS C 353 47.160 59.605 −32.479 1.00 66.74 N ATOM 10569 CE1 HIS C 353 47.996 59.932 −33.450 1.00 69.10 C ATOM 10570 NE2 HIS C 353 47.499 59.493 −34.593 1.00 68.51 N ATOM 10571 CD2 HIS C 353 46.301 58.861 −34.345 1.00 68.30 C ATOM 10572 C HIS C 353 44.311 56.861 −30.230 1.00 61.16 C ATOM 10573 O HIS C 353 43.797 57.686 −29.444 1.00 58.86 O ATOM 10574 N GLY C 354 43.976 55.567 −30.268 1.00 61.78 N ATOM 10575 CA GLY C 354 42.974 54.985 −29.387 1.00 60.08 C ATOM 10576 C GLY C 354 41.601 54.997 −29.987 1.00 58.33 C ATOM 10577 O GLY C 354 40.643 54.821 −29.244 1.00 60.53 O ATOM 10578 N TYR C 355 41.508 55.214 −31.308 1.00 57.14 N ATOM 10579 CA TYR C 355 40.273 55.022 −32.059 1.00 59.57 C ATOM 10580 CB TYR C 355 40.315 55.717 −33.410 1.00 66.46 C ATOM 10581 CG TYR C 355 40.087 57.217 −33.354 1.00 85.96 C ATOM 10582 CD1 TYR C 355 40.971 58.083 −32.643 1.00 93.18 C ATOM 10583 CE1 TYR C 355 40.765 59.467 −32.593 1.00 93.64 C ATOM 10584 CZ TYR C 355 39.671 60.017 −33.266 1.00 102.46 C ATOM 10585 OH TYR C 355 39.428 61.376 −33.238 1.00 102.82 O ATOM 10586 CE2 TYR C 355 38.801 59.191 −33.990 1.00 105.92 C ATOM 10587 CD2 TYR C 355 39.009 57.803 −34.034 1.00 98.25 C ATOM 10588 C TYR C 355 40.137 53.529 −32.289 1.00 57.91 C ATOM 10589 O TYR C 355 41.095 52.883 −32.763 1.00 59.69 O ATOM 10590 N VAL C 356 38.979 52.972 −31.926 1.00 52.84 N ATOM 10591 CA VAL C 356 38.703 51.549 −32.116 1.00 52.60 C ATOM 10592 CB VAL C 356 37.691 50.998 −31.078 1.00 54.75 C ATOM 10593 CG1 VAL C 356 37.425 49.514 −31.314 1.00 55.56 C ATOM 10594 CG2 VAL C 356 38.151 51.227 −29.655 1.00 53.06 C ATOM 10595 C VAL C 356 38.041 51.352 −33.456 1.00 49.80 C ATOM 10596 O VAL C 356 37.099 52.043 −33.767 1.00 46.07 O ATOM 10597 N HIS C 357 38.469 50.370 −34.223 1.00 52.32 N ATOM 10598 CA HIS C 357 37.818 50.080 −35.519 1.00 55.88 C ATOM 10599 CB HIS C 357 38.746 50.355 −36.725 1.00 59.49 C ATOM 10600 CG HIS C 357 39.001 51.806 −36.995 1.00 58.51 C ATOM 10601 ND1 HIS C 357 38.681 52.400 −38.193 1.00 58.47 N ATOM 10602 CE1 HIS C 357 38.993 53.680 −38.140 1.00 61.43 C ATOM 10603 NE2 HIS C 357 39.511 53.937 −36.954 1.00 59.43 N ATOM 10604 CD2 HIS C 357 39.542 52.776 −36.226 1.00 59.88 C ATOM 10605 C HIS C 357 37.456 48.623 −35.547 1.00 54.91 C ATOM 10606 O HIS C 357 38.295 47.779 −35.246 1.00 52.60 O ATOM 10607 N GLU C 358 36.225 48.338 −35.954 1.00 56.26 N ATOM 10608 CA GLU C 358 35.791 46.969 −36.164 1.00 56.27 C ATOM 10609 CB GLU C 358 34.347 46.832 −35.795 1.00 58.59 C ATOM 10610 CG GLU C 358 34.117 47.294 −34.379 1.00 61.13 C ATOM 10611 CD GLU C 358 32.764 46.897 −33.874 1.00 62.04 C ATOM 10612 OE1 GLU C 358 32.534 45.685 −33.635 1.00 56.56 O ATOM 10613 OE2 GLU C 358 31.933 47.824 −33.750 1.00 69.40 O ATOM 10614 C GLU C 358 36.012 46.641 −37.614 1.00 54.88 C ATOM 10615 O GLU C 358 35.355 47.179 −38.495 1.00 54.39 O ATOM 10616 N THR C 359 36.962 45.767 −37.887 1.00 54.30 N ATOM 10617 CA THR C 359 37.387 45.653 −39.256 1.00 54.05 C ATOM 10618 CB THR C 359 38.794 46.224 −39.494 1.00 50.96 C ATOM 10619 OG1 THR C 359 39.622 45.233 −40.103 1.00 52.14 O ATOM 10620 CG2 THR C 359 39.378 46.787 −38.243 1.00 47.63 C ATOM 10621 C THR C 359 37.127 44.250 −39.814 1.00 52.22 C ATOM 10622 O THR C 359 37.625 43.239 −39.341 1.00 54.38 O ATOM 10623 N LEU C 360 36.271 44.244 −40.803 1.00 49.33 N ATOM 10624 CA LEU C 360 35.873 43.075 −41.477 1.00 52.13 C ATOM 10625 CB LEU C 360 34.463 43.294 −42.044 1.00 55.97 C ATOM 10626 CG LEU C 360 33.949 42.304 −43.109 1.00 58.25 C ATOM 10627 CD1 LEU C 360 33.601 41.004 −42.417 1.00 56.25 C ATOM 10628 CD2 LEU C 360 32.784 42.869 −43.942 1.00 58.72 C ATOM 10629 C LEU C 360 36.860 42.813 −42.619 1.00 51.08 C ATOM 10630 O LEU C 360 37.055 43.656 −43.489 1.00 54.31 O ATOM 10631 N THR C 361 37.401 41.609 −42.643 1.00 47.34 N ATOM 10632 CA THR C 361 38.354 41.185 −43.627 1.00 47.71 C ATOM 10633 CB THR C 361 39.359 40.204 −42.974 1.00 47.33 C ATOM 10634 OG1 THR C 361 38.712 39.236 −42.107 1.00 49.67 O ATOM 10635 CG2 THR C 361 40.285 40.987 −42.140 1.00 47.74 C ATOM 10636 C THR C 361 37.703 40.510 −44.816 1.00 49.82 C ATOM 10637 O THR C 361 36.999 39.540 −44.630 1.00 55.74 O ATOM 10638 N VAL C 362 37.967 40.982 −46.038 1.00 50.38 N ATOM 10639 CA VAL C 362 37.466 40.331 −47.281 1.00 48.47 C ATOM 10640 CB VAL C 362 36.372 41.170 −47.940 1.00 50.15 C ATOM 10641 CG1 VAL C 362 35.265 41.440 −46.952 1.00 51.77 C ATOM 10642 CG2 VAL C 362 36.900 42.499 −48.468 1.00 52.27 C ATOM 10643 C VAL C 362 38.580 40.123 −48.282 1.00 47.04 C ATOM 10644 O VAL C 362 39.565 40.819 −48.188 1.00 44.92 O ATOM 10645 N TYR C 363 38.422 39.184 −49.220 1.00 50.37 N ATOM 10646 CA TYR C 363 39.446 38.894 −50.257 1.00 56.43 C ATOM 10647 CB TYR C 363 39.192 37.602 −51.041 1.00 59.78 C ATOM 10648 CG TYR C 363 39.542 36.380 −50.258 1.00 68.48 C ATOM 10649 CD1 TYR C 363 40.856 36.118 −49.931 1.00 73.24 C ATOM 10650 CE1 TYR C 363 41.196 35.007 −49.165 1.00 76.10 C ATOM 10651 CZ TYR C 363 40.216 34.124 −48.748 1.00 76.60 C ATOM 10652 OH TYR C 363 40.629 33.056 −48.009 1.00 82.67 O ATOM 10653 CE2 TYR C 363 38.881 34.340 −49.057 1.00 73.25 C ATOM 10654 CD2 TYR C 363 38.548 35.470 −49.804 1.00 73.31 C ATOM 10655 C TYR C 363 39.584 39.973 −51.285 1.00 58.39 C ATOM 10656 O TYR C 363 40.697 40.153 −51.769 1.00 60.66 O ATOM 10657 N LYS C 364 38.469 40.634 −51.629 1.00 59.20 N ATOM 10658 CA LYS C 364 38.391 41.612 −52.726 1.00 64.50 C ATOM 10659 CB LYS C 364 37.986 40.941 −54.049 1.00 74.47 C ATOM 10660 CG LYS C 364 39.085 40.854 −55.137 1.00 87.51 C ATOM 10661 CD LYS C 364 40.012 39.613 −55.082 1.00 94.46 C ATOM 10662 CE LYS C 364 39.272 38.271 −55.244 1.00 97.47 C ATOM 10663 NZ LYS C 364 39.649 37.457 −56.435 1.00 98.52 N ATOM 10664 C LYS C 364 37.452 42.807 −52.465 1.00 61.34 C ATOM 10665 O LYS C 364 36.395 42.691 −51.844 1.00 57.80 O ATOM 10666 N ALA C 365 37.847 43.964 −52.970 1.00 57.60 N ATOM 10667 CA ALA C 365 37.054 45.146 −52.797 1.00 56.66 C ATOM 10668 CB ALA C 365 37.504 45.878 −51.567 1.00 56.77 C ATOM 10669 C ALA C 365 37.177 46.015 −54.006 1.00 57.44 C ATOM 10670 O ALA C 365 38.084 45.865 −54.784 1.00 64.68 O ATOM 10671 N CYS C 366 36.255 46.938 −54.156 1.00 59.73 N ATOM 10672 CA CYS C 366 36.144 47.716 −55.373 1.00 65.32 C ATOM 10673 CB CYS C 366 34.962 47.200 −56.166 1.00 67.01 C ATOM 10674 SG CYS C 366 35.421 45.652 −56.916 1.00 70.80 S ATOM 10675 C CYS C 366 35.945 49.181 −55.091 1.00 63.72 C ATOM 10676 O CYS C 366 35.554 49.535 −53.985 1.00 68.53 O ATOM 10677 N ASN C 367 36.188 50.013 −56.104 1.00 54.92 N ATOM 10678 CA ASN C 367 35.939 51.446 −56.022 1.00 53.17 C ATOM 10679 CB ASN C 367 34.440 51.733 −55.976 1.00 52.34 C ATOM 10680 CG ASN C 367 33.655 50.913 −56.946 1.00 48.55 C ATOM 10681 OD1 ASN C 367 32.745 50.212 −56.558 1.00 47.29 O ATOM 10682 ND2 ASN C 367 34.023 50.952 −58.189 1.00 48.73 N ATOM 10683 C ASN C 367 36.592 52.122 −54.829 1.00 54.27 C ATOM 10684 O ASN C 367 36.026 53.041 −54.181 1.00 51.28 O ATOM 10685 N LEU C 368 37.777 51.628 −54.519 1.00 56.96 N ATOM 10686 CA LEU C 368 38.536 52.139 −53.418 1.00 56.09 C ATOM 10687 CB LEU C 368 38.894 51.010 −52.476 1.00 54.24 C ATOM 10688 CG LEU C 368 37.791 50.303 −51.736 1.00 51.55 C ATOM 10689 CD1 LEU C 368 38.390 49.324 −50.723 1.00 53.04 C ATOM 10690 CD2 LEU C 368 36.937 51.348 −51.046 1.00 52.49 C ATOM 10691 C LEU C 368 39.766 52.701 −54.067 1.00 56.35 C ATOM 10692 O LEU C 368 40.301 52.092 −54.992 1.00 61.83 O ATOM 10693 N ASN C 369 40.171 53.879 −53.640 1.00 54.58 N ATOM 10694 CA ASN C 369 41.404 54.476 −54.121 1.00 55.13 C ATOM 10695 CB ASN C 369 41.180 55.927 −54.615 1.00 54.12 C ATOM 10696 CG ASN C 369 40.545 55.982 −55.991 1.00 57.35 C ATOM 10697 OD1 ASN C 369 40.665 55.040 −56.764 1.00 65.22 O ATOM 10698 ND2 ASN C 369 39.855 57.074 −56.307 1.00 62.32 N ATOM 10699 C ASN C 369 42.329 54.334 −52.925 1.00 54.38 C ATOM 10700 O ASN C 369 41.849 54.400 −51.777 1.00 55.08 O ATOM 10701 N LEU C 370 43.615 54.070 −53.201 1.00 51.25 N ATOM 10702 CA LEU C 370 44.642 53.802 −52.178 1.00 48.72 C ATOM 10703 CB LEU C 370 45.508 52.648 −52.601 1.00 45.31 C ATOM 10704 CG LEU C 370 44.758 51.362 −52.797 1.00 44.46 C ATOM 10705 CD1 LEU C 370 45.451 50.405 −53.755 1.00 42.70 C ATOM 10706 CD2 LEU C 370 44.530 50.739 −51.432 1.00 46.40 C ATOM 10707 C LEU C 370 45.530 54.999 −52.081 1.00 52.46 C ATOM 10708 O LEU C 370 46.037 55.478 −53.091 1.00 57.05 O ATOM 10709 N ILE C 371 45.727 55.539 −50.903 1.00 57.54 N ATOM 10710 CA ILE C 371 46.541 56.743 −50.863 1.00 65.22 C ATOM 10711 CB ILE C 371 45.709 58.067 −50.732 1.00 69.81 C ATOM 10712 CG1 ILE C 371 45.301 58.340 −49.290 1.00 74.09 C ATOM 10713 CD1 ILE C 371 46.270 59.242 −48.544 1.00 80.49 C ATOM 10714 CG2 ILE C 371 44.477 58.052 −51.656 1.00 68.15 C ATOM 10715 C ILE C 371 47.598 56.526 −49.821 1.00 61.40 C ATOM 10716 O ILE C 371 47.377 55.827 −48.857 1.00 61.03 O ATOM 10717 N GLY C 372 48.759 57.116 −50.052 1.00 62.66 N ATOM 10718 CA GLY C 372 49.933 56.866 −49.230 1.00 62.72 C ATOM 10719 C GLY C 372 50.642 55.568 −49.560 1.00 60.91 C ATOM 10720 O GLY C 372 50.268 54.854 −50.504 1.00 54.32 O ATOM 10721 N ARG C 373 51.673 55.268 −48.766 1.00 62.57 N ATOM 10722 CA ARG C 373 52.475 54.111 −49.034 1.00 63.26 C ATOM 10723 CB ARG C 373 53.845 54.569 −49.516 1.00 70.60 C ATOM 10724 CG ARG C 373 54.009 54.230 −51.003 1.00 80.59 C ATOM 10725 CD ARG C 373 54.534 55.318 −51.919 1.00 88.87 C ATOM 10726 NE ARG C 373 55.913 55.097 −52.388 1.00 102.49 N ATOM 10727 CZ ARG C 373 56.386 53.997 −53.008 1.00 107.67 C ATOM 10728 NH1 ARG C 373 57.674 53.967 −53.399 1.00 107.60 N ATOM 10729 NH2 ARG C 373 55.610 52.916 −53.232 1.00 106.17 N ATOM 10730 C ARG C 373 52.452 53.015 −47.959 1.00 57.81 C ATOM 10731 O ARG C 373 52.157 53.296 −46.787 1.00 56.79 O ATOM 10732 N PRO C 374 52.645 51.738 −48.379 1.00 52.75 N ATOM 10733 CA PRO C 374 52.359 50.657 −47.449 1.00 53.03 C ATOM 10734 CB PRO C 374 52.682 49.385 −48.259 1.00 51.32 C ATOM 10735 CG PRO C 374 52.350 49.771 −49.639 1.00 50.56 C ATOM 10736 CD PRO C 374 52.899 51.182 −49.716 1.00 53.08 C ATOM 10737 C PRO C 374 53.221 50.766 −46.254 1.00 50.84 C ATOM 10738 O PRO C 374 54.311 51.259 −46.387 1.00 57.62 O ATOM 10739 N SER C 375 52.715 50.370 −45.101 1.00 48.15 N ATOM 10740 CA SER C 375 53.438 50.532 −43.846 1.00 49.11 C ATOM 10741 CB SER C 375 53.055 51.834 −43.131 1.00 47.80 C ATOM 10742 OG SER C 375 53.597 51.923 −41.825 1.00 44.07 O ATOM 10743 C SER C 375 53.044 49.383 −43.002 1.00 52.63 C ATOM 10744 O SER C 375 51.922 48.899 −43.112 1.00 57.57 O ATOM 10745 N THR C 376 53.961 48.966 −42.142 1.00 53.34 N ATOM 10746 CA THR C 376 53.717 47.886 −41.209 1.00 51.18 C ATOM 10747 CB THR C 376 54.877 46.935 −41.286 1.00 47.74 C ATOM 10748 OG1 THR C 376 56.023 47.591 −40.759 1.00 47.05 O ATOM 10749 CG2 THR C 376 55.162 46.601 −42.702 1.00 48.45 C ATOM 10750 C THR C 376 53.624 48.471 −39.796 1.00 53.32 C ATOM 10751 O THR C 376 53.603 47.736 −38.797 1.00 56.85 O ATOM 10752 N GLU C 377 53.559 49.796 −39.710 1.00 54.24 N ATOM 10753 CA GLU C 377 53.641 50.448 −38.432 1.00 57.82 C ATOM 10754 CB GLU C 377 53.921 51.935 −38.567 1.00 60.62 C ATOM 10755 CG GLU C 377 54.524 52.555 −37.330 1.00 67.35 C ATOM 10756 CD GLU C 377 54.651 54.066 −37.454 1.00 82.35 C ATOM 10757 OE1 GLU C 377 54.350 54.661 −38.561 1.00 92.77 O ATOM 10758 OE2 GLU C 377 55.043 54.658 −36.419 1.00 84.76 O ATOM 10759 C GLU C 377 52.326 50.198 −37.771 1.00 55.27 C ATOM 10760 O GLU C 377 51.285 50.490 −38.333 1.00 62.99 O ATOM 10761 N HIS C 378 52.382 49.572 −36.615 1.00 51.49 N ATOM 10762 CA HIS C 378 51.226 49.393 −35.771 1.00 50.76 C ATOM 10763 CB HIS C 378 50.636 −50.741 −35.461 1.00 50.11 C ATOM 10764 CG HIS C 378 49.831 50.759 −34.227 1.00 51.40 C ATOM 10765 ND1 HIS C 378 48.462 50.659 −34.235 1.00 57.26 N ATOM 10766 CE1 HIS C 378 48.005 50.760 −33.000 1.00 56.04 C ATOM 10767 NE2 HIS C 378 49.036 50.908 −32.196 1.00 53.88 N ATOM 10768 CD2 HIS C 378 50.190 50.907 −32.941 1.00 53.83 C ATOM 10769 C HIS C 378 50.189 48.485 −36.391 1.00 48.51 C ATOM 10770 O HIS C 378 49.020 48.518 −36.019 1.00 50.74 O ATOM 10771 N SER C 379 50.634 47.646 −37.313 1.00 45.39 N ATOM 10772 CA SER C 379 49.724 46.834 −38.057 1.00 45.00 C ATOM 10773 CB SER C 379 50.399 46.156 −39.216 1.00 43.37 C ATOM 10774 OG SER C 379 49.527 45.182 −39.703 1.00 41.91 O ATOM 10775 C SER C 379 49.114 45.764 −37.186 1.00 50.14 C ATOM 10776 O SER C 379 49.794 45.001 −36.503 1.00 55.29 O ATOM 10777 N TRP C 380 47.807 45.674 −37.298 1.00 54.02 N ATOM 10778 CA TRP C 380 46.991 44.773 −36.516 1.00 52.59 C ATOM 10779 CB TRP C 380 45.546 45.214 −36.652 1.00 51.97 C ATOM 10780 CG TRP C 380 45.248 46.556 −36.216 1.00 52.35 C ATOM 10781 CD1 TRP C 380 45.794 47.232 −35.176 1.00 52.72 C ATOM 10782 NE1 TRP C 380 45.223 48.482 −35.074 1.00 53.90 N ATOM 10783 CE2 TRP C 380 44.262 48.597 −36.044 1.00 52.06 C ATOM 10784 CD2 TRP C 380 44.270 47.411 −36.791 1.00 53.21 C ATOM 10785 CE3 TRP C 380 43.387 47.282 −37.861 1.00 52.77 C ATOM 10786 CZ3 TRP C 380 42.548 48.327 −38.150 1.00 51.84 C ATOM 10787 CH2 TRP C 380 42.565 49.483 −37.383 1.00 51.86 C ATOM 10788 CZ2 TRP C 380 43.410 49.627 −36.322 1.00 50.98 C ATOM 10789 C TRP C 380 47.055 43.308 −36.980 1.00 52.11 C ATOM 10790 O TRP C 380 46.584 42.391 −36.277 1.00 54.45 O ATOM 10791 N PHE C 381 47.553 43.103 −38.186 1.00 49.89 N ATOM 10792 CA PHE C 381 47.734 41.781 −38.706 1.00 51.02 C ATOM 10793 CB PHE C 381 46.889 41.583 −39.949 1.00 50.95 C ATOM 10794 CG PHE C 381 45.418 41.654 −39.720 1.00 47.99 C ATOM 10795 CD1 PHE C 381 44.721 40.532 −39.406 1.00 46.54 C ATOM 10796 CE1 PHE C 381 43.378 40.565 −39.241 1.00 47.87 C ATOM 10797 CZ PHE C 381 42.697 41.745 −39.423 1.00 49.21 C ATOM 10798 CE2 PHE C 381 43.379 42.873 −39.789 1.00 48.95 C ATOM 10799 CD2 PHE C 381 44.741 42.819 −39.943 1.00 49.04 C ATOM 10800 C PHE C 381 49.197 41.648 −39.073 1.00 50.17 C ATOM 10801 O PHE C 381 49.587 42.056 −40.152 1.00 51.21 O ATOM 10802 N PRO C 382 50.019 41.084 −38.181 1.00 50.59 N ATOM 10803 CA PRO C 382 51.442 41.025 −38.467 1.00 52.39 C ATOM 10804 CB PRO C 382 52.009 40.411 −37.215 1.00 51.15 C ATOM 10805 CG PRO C 382 51.120 40.931 −36.159 1.00 51.04 C ATOM 10806 CD PRO C 382 49.769 40.757 −36.776 1.00 50.87 C ATOM 10807 C PRO C 382 51.828 40.202 −39.666 1.00 55.27 C ATOM 10808 O PRO C 382 51.225 39.152 −39.951 1.00 55.66 O ATOM 10809 N GLY C 383 52.824 40.718 −40.378 1.00 56.47 N ATOM 10810 CA GLY C 383 53.231 40.142 −41.656 1.00 58.57 C ATOM 10811 C GLY C 383 52.639 40.945 −42.785 1.00 57.15 C ATOM 10812 O GLY C 383 53.139 40.923 −43.878 1.00 56.06 O ATOM 10813 N TYR C 384 51.577 41.676 −42.504 1.00 57.82 N ATOM 10814 CA TYR C 384 50.943 42.479 −43.490 1.00 57.05 C ATOM 10815 CB TYR C 384 49.453 42.093 −43.584 1.00 58.31 C ATOM 10816 CG TYR C 384 49.199 40.711 −44.150 1.00 57.53 C ATOM 10817 CD1 TYR C 384 49.330 40.465 −45.499 1.00 60.22 C ATOM 10818 CE1 TYR C 384 49.112 39.189 −46.032 1.00 63.00 C ATOM 10819 CZ TYR C 384 48.725 38.129 −45.204 1.00 61.12 C ATOM 10820 OH TYR C 384 48.498 36.886 −45.727 1.00 53.17 O ATOM 10821 CE2 TYR C 384 48.558 38.361 −43.853 1.00 61.16 C ATOM 10822 CD2 TYR C 384 48.802 39.651 −43.336 1.00 61.37 C ATOM 10823 C TYR C 384 51.193 43.992 −43.191 1.00 56.81 C ATOM 10824 O TYR C 384 51.361 44.446 −42.009 1.00 53.77 O ATOM 10825 N ALA C 385 51.311 44.722 −44.306 1.00 53.88 N ATOM 10826 CA ALA C 385 51.361 46.159 −44.329 1.00 52.95 C ATOM 10827 CB ALA C 385 52.412 46.636 −45.286 1.00 51.79 C ATOM 10828 C ALA C 385 50.022 46.677 −44.793 1.00 55.28 C ATOM 10829 O ALA C 385 49.314 46.022 −45.563 1.00 55.77 O ATOM 10830 N TRP C 386 49.726 47.899 −44.367 1.00 54.32 N ATOM 10831 CA TRP C 386 48.453 48.514 −44.602 1.00 53.20 C ATOM 10832 CB TRP C 386 47.766 48.831 −43.282 1.00 51.97 C ATOM 10833 CG TRP C 386 48.539 49.599 −42.337 1.00 51.56 C ATOM 10834 CD1 TRP C 386 49.260 49.110 −41.311 1.00 52.93 C ATOM 10835 NE1 TRP C 386 49.872 50.133 −40.609 1.00 53.61 N ATOM 10836 CE2 TRP C 386 49.537 51.320 −41.191 1.00 53.47 C ATOM 10837 CD2 TRP C 386 48.688 51.020 −42.295 1.00 53.55 C ATOM 10838 CE3 TRP C 386 48.192 52.074 −43.071 1.00 50.53 C ATOM 10839 CZ3 TRP C 386 48.548 53.368 −42.723 1.00 50.36 C ATOM 10840 CH2 TRP C 386 49.347 53.627 −41.599 1.00 50.77 C ATOM 10841 CZ2 TRP C 386 49.862 52.618 −40.828 1.00 50.83 C ATOM 10842 C TRP C 386 48.615 49.759 −45.447 1.00 53.53 C ATOM 10843 O TRP C 386 49.555 50.506 −45.273 1.00 60.62 O ATOM 10844 N THR C 387 47.699 49.953 −46.380 1.00 52.97 N ATOM 10845 CA THR C 387 47.568 51.187 −47.148 1.00 52.60 C ATOM 10846 CB THR C 387 47.671 50.915 −48.644 1.00 53.67 C ATOM 10847 OG1 THR C 387 48.924 50.279 −48.938 1.00 57.32 O ATOM 10848 CG2 THR C 387 47.496 52.184 −49.432 1.00 52.77 C ATOM 10849 C THR C 387 46.160 51.659 −46.950 1.00 50.11 C ATOM 10850 O THR C 387 45.256 50.854 −46.951 1.00 53.44 O ATOM 10851 N VAL C 388 45.970 52.953 −46.825 1.00 46.97 N ATOM 10852 CA VAL C 388 44.650 53.515 −46.586 1.00 46.18 C ATOM 10853 CB VAL C 388 44.824 54.970 −46.107 1.00 45.36 C ATOM 10854 CG1 VAL C 388 43.533 55.787 −46.122 1.00 44.74 C ATOM 10855 CG2 VAL C 388 45.436 54.964 −44.736 1.00 46.64 C ATOM 10856 C VAL C 388 43.777 53.452 −47.852 1.00 47.76 C ATOM 10857 O VAL C 388 44.224 53.815 −48.934 1.00 49.17 O ATOM 10858 N ALA C 389 42.529 53.013 −47.701 1.00 49.13 N ATOM 10859 CA ALA C 389 41.566 52.960 −48.807 1.00 50.92 C ATOM 10860 CB ALA C 389 40.998 51.563 −48.919 1.00 51.61 C ATOM 10861 C ALA C 389 40.420 53.947 −48.592 1.00 52.68 C ATOM 10862 O ALA C 389 39.861 53.992 −47.475 1.00 53.97 O ATOM 10863 N GLN C 390 40.060 54.710 −49.637 1.00 50.12 N ATOM 10864 CA GLN C 390 38.858 55.532 −49.579 1.00 50.43 C ATOM 10865 CB GLN C 390 39.181 57.036 −49.363 1.00 50.20 C ATOM 10866 CG GLN C 390 40.508 57.546 −49.884 1.00 53.02 C ATOM 10867 CD GLN C 390 40.975 58.898 −49.280 1.00 54.09 C ATOM 10868 OE1 GLN C 390 41.359 58.963 −48.132 1.00 59.38 O ATOM 10869 NE2 GLN C 390 41.010 59.945 −50.084 1.00 52.65 N ATOM 10870 C GLN C 390 37.871 55.272 −50.731 1.00 51.32 C ATOM 10871 O GLN C 390 38.220 54.672 −51.736 1.00 52.84 O ATOM 10872 N CYS C 391 36.619 55.688 −50.533 1.00 50.95 N ATOM 10873 CA CYS C 391 35.601 55.660 −51.566 1.00 51.82 C ATOM 10874 CB CYS C 391 34.249 56.095 −51.013 1.00 53.56 C ATOM 10875 SG CYS C 391 32.721 55.917 −52.024 1.00 58.62 S ATOM 10876 C CYS C 391 36.042 56.630 −52.637 1.00 53.32 C ATOM 10877 O CYS C 391 36.244 57.830 −52.409 1.00 57.91 O ATOM 10878 N LYS C 392 35.996 56.074 −53.820 1.00 50.33 N ATOM 10879 CA LYS C 392 36.326 56.669 −55.058 1.00 44.20 C ATOM 10880 CB LYS C 392 36.001 55.606 −56.086 1.00 43.62 C ATOM 10881 CG LYS C 392 35.688 56.075 −57.468 1.00 46.84 C ATOM 10882 CD LYS C 392 34.752 55.107 −58.162 1.00 45.10 C ATOM 10883 CE LYS C 392 35.427 53.815 −58.518 1.00 45.47 C ATOM 10884 NZ LYS C 392 34.561 53.091 −59.471 1.00 46.85 N ATOM 10885 C LYS C 392 35.458 57.882 −55.245 1.00 42.93 C ATOM 10886 O LYS C 392 35.889 58.853 −55.794 1.00 42.11 O ATOM 10887 N ILE C 393 34.218 57.829 −54.809 1.00 41.91 N ATOM 10888 CA ILE C 393 33.315 58.950 −54.973 1.00 42.65 C ATOM 10889 CB ILE C 393 31.885 58.424 −55.008 1.00 44.17 C ATOM 10890 CG1 ILE C 393 31.789 57.203 −55.881 1.00 44.37 C ATOM 10891 CD1 ILE C 393 31.852 57.506 −57.344 1.00 44.99 C ATOM 10892 CG2 ILE C 393 30.927 59.476 −55.502 1.00 43.96 C ATOM 10893 C ILE C 393 33.236 60.036 −53.930 1.00 42.33 C ATOM 10894 O ILE C 393 33.250 61.185 −54.244 1.00 48.08 O ATOM 10895 N CYS C 394 33.129 59.646 −52.685 1.00 41.11 N ATOM 10896 CA CYS C 394 32.911 60.521 −51.551 1.00 42.59 C ATOM 10897 CB CYS C 394 31.779 59.967 −50.670 1.00 40.60 C ATOM 10898 SG CYS C 394 32.085 58.445 −49.811 1.00 41.76 S ATOM 10899 C CYS C 394 34.147 60.783 −50.705 1.00 46.71 C ATOM 10900 O CYS C 394 34.119 61.662 −49.855 1.00 50.52 O ATOM 10901 N ALA C 395 35.225 60.027 −50.940 1.00 48.52 N ATOM 10902 CA ALA C 395 36.484 60.168 −50.208 1.00 45.80 C ATOM 10903 CB ALA C 395 36.866 61.616 −50.149 1.00 45.61 C ATOM 10904 C ALA C 395 36.492 59.544 −48.794 1.00 47.94 C ATOM 10905 O ALA C 395 37.475 59.654 −48.034 1.00 46.06 O ATOM 10906 N SER C 396 35.424 58.832 −48.446 1.00 50.73 N ATOM 10907 CA SER C 396 35.270 58.345 −47.085 1.00 50.59 C ATOM 10908 CB SER C 396 33.855 57.786 −46.847 1.00 52.05 C ATOM 10909 OG SER C 396 32.873 58.827 −46.856 1.00 58.68 O ATOM 10910 C SER C 396 36.329 57.288 −46.829 1.00 50.09 C ATOM 10911 O SER C 396 36.541 56.415 −47.632 1.00 47.09 O ATOM 10912 N HIS C 397 37.017 57.400 −45.710 1.00 53.33 N ATOM 10913 CA HIS C 397 37.879 56.353 −45.280 1.00 54.59 C ATOM 10914 CB HIS C 397 38.655 56.794 −44.066 1.00 58.23 C ATOM 10915 CG HIS C 397 39.667 55.803 −43.639 1.00 67.82 C ATOM 10916 ND1 HIS C 397 39.323 54.572 −43.117 1.00 77.34 N ATOM 10917 CE1 HIS C 397 40.418 53.892 −42.852 1.00 80.46 C ATOM 10918 NE2 HIS C 397 41.457 54.635 −43.194 1.00 82.40 N ATOM 10919 CD2 HIS C 397 41.013 55.836 −43.685 1.00 71.07 C ATOM 10920 C HIS C 397 37.039 55.099 −45.004 1.00 55.08 C ATOM 10921 O HIS C 397 36.421 54.961 −43.951 1.00 53.65 O ATOM 10922 N ILE C 398 37.028 54.202 −45.985 1.00 56.59 N ATOM 10923 CA ILE C 398 36.366 52.884 −45.918 1.00 55.63 C ATOM 10924 CB ILE C 398 36.120 52.356 −47.373 1.00 55.85 C ATOM 10925 CG1 ILE C 398 35.063 53.189 −48.074 1.00 59.80 C ATOM 10926 CD1 ILE C 398 33.763 53.358 −47.313 1.00 63.49 C ATOM 10927 CG2 ILE C 398 35.671 50.920 −47.461 1.00 55.04 C ATOM 10928 C ILE C 398 37.164 51.837 −45.125 1.00 55.91 C ATOM 10929 O ILE C 398 36.571 50.877 −44.645 1.00 57.92 O ATOM 10930 N GLY C 399 38.492 51.979 −45.002 1.00 55.44 N ATOM 10931 CA GLY C 399 39.354 50.850 −44.535 1.00 51.73 C ATOM 10932 C GLY C 399 40.817 50.865 −44.995 1.00 48.62 C ATOM 10933 O GLY C 399 41.449 51.945 −45.123 1.00 48.63 O ATOM 10934 N TRP C 400 41.363 49.670 −45.200 1.00 42.81 N ATOM 10935 CA TRP C 400 42.744 49.513 −45.584 1.00 44.53 C ATOM 10936 CB TRP C 400 43.669 49.360 −44.356 1.00 45.66 C ATOM 10937 CG TRP C 400 43.625 50.497 −43.357 1.00 46.57 C ATOM 10938 CD1 TRP C 400 44.434 51.585 −43.316 1.00 47.05 C ATOM 10939 NE1 TRP C 400 44.084 52.405 −42.287 1.00 47.56 N ATOM 10940 CE2 TRP C 400 43.027 51.838 −41.634 1.00 49.37 C ATOM 10941 CD2 TRP C 400 42.721 50.638 −42.282 1.00 47.78 C ATOM 10942 CE3 TRP C 400 41.667 49.858 −41.799 1.00 51.80 C ATOM 10943 CZ3 TRP C 400 40.974 50.282 −40.688 1.00 53.57 C ATOM 10944 CH2 TRP C 400 41.303 51.495 −40.057 1.00 54.33 C ATOM 10945 CZ2 TRP C 400 42.325 52.282 −40.517 1.00 53.39 C ATOM 10946 C TRP C 400 42.926 48.286 −46.446 1.00 47.26 C ATOM 10947 O TRP C 400 42.432 47.197 −46.128 1.00 49.37 O ATOM 10948 N LYS C 401 43.648 48.449 −47.541 1.00 49.85 N ATOM 10949 CA LYS C 401 44.212 47.311 −48.242 1.00 51.10 C ATOM 10950 CB LYS C 401 44.705 47.748 −49.592 1.00 49.87 C ATOM 10951 CG LYS C 401 45.155 46.591 −50.402 1.00 50.51 C ATOM 10952 CD LYS C 401 45.605 47.039 −51.767 1.00 52.22 C ATOM 10953 CE LYS C 401 45.951 45.770 −52.523 1.00 54.14 C ATOM 10954 NZ LYS C 401 45.524 45.913 −53.915 1.00 59.62 N ATOM 10955 C LYS C 401 45.397 46.784 −47.441 1.00 53.72 C ATOM 10956 O LYS C 401 46.259 47.566 −47.048 1.00 55.77 O ATOM 10957 N PHE C 402 45.453 45.470 −47.214 1.00 55.85 N ATOM 10958 CA PHE C 402 46.620 44.819 −46.572 1.00 53.27 C ATOM 10959 CB PHE C 402 46.207 43.945 −45.388 1.00 51.61 C ATOM 10960 CG PHE C 402 45.719 44.730 −44.184 1.00 49.13 C ATOM 10961 CD2 PHE C 402 44.392 45.025 −44.020 1.00 46.56 C ATOM 10962 CE2 PHE C 402 43.960 45.736 −42.918 1.00 46.24 C ATOM 10963 CZ PHE C 402 44.850 46.171 −41.978 1.00 44.51 C ATOM 10964 CE1 PHE C 402 46.171 45.886 −42.127 1.00 46.67 C ATOM 10965 CD1 PHE C 402 46.607 45.181 −43.225 1.00 48.88 C ATOM 10966 C PHE C 402 47.369 43.991 −47.595 1.00 55.34 C ATOM 10967 O PHE C 402 46.760 43.340 −48.455 1.00 55.47 O ATOM 10968 N THR C 403 48.698 44.045 −47.500 1.00 59.11 N ATOM 10969 CA THR C 403 49.637 43.453 −48.498 1.00 56.23 C ATOM 10970 CB THR C 403 50.225 44.526 −49.475 1.00 49.96 C ATOM 10971 OG1 THR C 403 50.804 45.618 −48.750 1.00 46.32 O ATOM 10972 CG2 THR C 403 49.149 45.070 −50.311 1.00 47.32 C ATOM 10973 C THR C 403 50.768 42.722 −47.750 1.00 56.56 C ATOM 10974 O THR C 403 51.266 43.212 −46.732 1.00 58.24 O ATOM 10975 N ALA C 404 51.146 41.552 −48.255 1.00 57.04 N ATOM 10976 CA ALA C 404 52.140 40.683 −47.623 1.00 58.15 C ATOM 10977 CB ALA C 404 52.066 39.336 −48.280 1.00 61.48 C ATOM 10978 C ALA C 404 53.581 41.199 −47.704 1.00 58.44 C ATOM 10979 O ALA C 404 53.951 41.730 −48.727 1.00 61.73 O ATOM 10980 N THR C 405 54.372 41.035 −46.633 1.00 60.89 N ATOM 10981 CA THR C 405 55.774 41.515 −46.568 1.00 61.21 C ATOM 10982 CB THR C 405 56.233 42.153 −45.195 1.00 60.72 C ATOM 10983 OG1 THR C 405 55.929 41.314 −44.081 1.00 64.18 O ATOM 10984 CG2 THR C 405 55.562 43.492 −44.947 1.00 59.65 C ATOM 10985 C THR C 405 56.742 40.443 −47.008 1.00 62.56 C ATOM 10986 O THR C 405 57.746 40.792 −47.546 1.00 65.05 O ATOM 10987 N LYS C 406 56.436 39.159 −46.795 1.00 72.23 N ATOM 10988 CA LYS C 406 57.206 38.016 −47.350 1.00 73.01 C ATOM 10989 CB LYS C 406 57.461 36.946 −46.278 1.00 78.76 C ATOM 10990 CG LYS C 406 57.717 37.388 −44.821 1.00 84.74 C ATOM 10991 CD LYS C 406 57.731 36.133 −43.923 1.00 94.25 C ATOM 10992 CE LYS C 406 56.961 36.241 −42.600 1.00 100.40 C ATOM 10993 NZ LYS C 406 57.817 36.011 −41.396 1.00 104.54 N ATOM 10994 C LYS C 406 56.397 37.377 −48.491 1.00 73.88 C ATOM 10995 O LYS C 406 55.172 37.383 −48.462 1.00 72.19 O ATOM 10996 N LYS C 407 57.066 36.778 −49.470 1.00 81.65 N ATOM 10997 CA LYS C 407 56.420 36.402 −50.757 1.00 84.93 C ATOM 10998 CB LYS C 407 57.388 36.635 −51.913 1.00 93.10 C ATOM 10999 CG LYS C 407 57.837 38.101 −52.012 1.00 104.68 C ATOM 11000 CD LYS C 407 56.969 38.916 −52.956 1.00 104.60 C ATOM 11001 CE LYS C 407 57.445 38.691 −54.386 1.00 106.38 C ATOM 11002 NZ LYS C 407 56.332 38.784 −55.368 1.00 108.87 N ATOM 11003 C LYS C 407 55.877 34.997 −50.819 1.00 79.45 C ATOM 11004 O LYS C 407 55.467 34.551 −51.864 1.00 78.10 O ATOM 11005 N ASP C 408 55.818 34.332 −49.679 1.00 81.30 N ATOM 11006 CA ASP C 408 55.269 32.984 −49.549 1.00 85.40 C ATOM 11007 CB ASP C 408 56.397 32.075 −49.091 1.00 87.70 C ATOM 11008 CG ASP C 408 56.917 32.473 −47.729 1.00 87.25 C ATOM 11009 OD1 ASP C 408 57.253 33.656 −47.547 1.00 84.95 O ATOM 11010 OD2 ASP C 408 56.943 31.629 −46.828 1.00 100.38 O ATOM 11011 C ASP C 408 54.133 32.908 −48.500 1.00 87.26 C ATOM 11012 O ASP C 408 53.797 31.818 −48.029 1.00 92.52 O ATOM 11013 N MET C 409 53.613 34.059 −48.121 1.00 86.38 N ATOM 11014 CA MET C 409 52.528 34.131 −47.185 1.00 79.70 C ATOM 11015 CB MET C 409 52.416 35.524 −46.615 1.00 77.96 C ATOM 11016 CG MET C 409 53.541 35.994 −45.743 1.00 74.98 C ATOM 11017 SD MET C 409 52.931 37.477 −44.967 1.00 75.58 S ATOM 11018 CE MET C 409 54.194 37.755 −43.754 1.00 79.27 C ATOM 11019 C MET C 409 51.314 33.952 −48.022 1.00 75.41 C ATOM 11020 O MET C 409 51.356 34.211 −49.200 1.00 74.86 O ATOM 11021 N SER C 410 50.224 33.516 −47.427 1.00 72.56 N ATOM 11022 CA SER C 410 48.991 33.421 −48.159 1.00 73.08 C ATOM 11023 CB SER C 410 48.744 32.029 −48.667 1.00 78.16 C ATOM 11024 OG SER C 410 47.460 31.974 −49.242 1.00 81.84 O ATOM 11025 C SER C 410 47.901 33.795 −47.205 1.00 69.09 C ATOM 11026 O SER C 410 47.907 33.296 −46.103 1.00 66.45 O ATOM 11027 N PRO C 411 46.887 34.664 −47.590 1.00 63.85 N ATOM 11028 CA PRO C 411 46.956 35.239 −48.934 1.00 62.37 C ATOM 11029 CB PRO C 411 45.555 35.727 −49.139 1.00 65.32 C ATOM 11030 CG PRO C 411 45.264 36.341 −47.850 1.00 68.06 C ATOM 11031 CD PRO C 411 45.626 35.239 −46.940 1.00 67.59 C ATOM 11032 C PRO C 411 47.889 36.432 −49.034 1.00 62.80 C ATOM 11033 O PRO C 411 48.234 36.992 −48.012 1.00 63.03 O ATOM 11034 N GLN C 412 48.299 36.778 −50.254 1.00 64.57 N ATOM 11035 CA GLN C 412 49.184 37.908 −50.543 1.00 65.40 C ATOM 11036 CB GLN C 412 49.682 37.856 −51.981 1.00 67.79 C ATOM 11037 CG GLN C 412 50.895 36.970 −52.192 1.00 68.80 C ATOM 11038 CD GLN C 412 52.150 37.541 −51.590 1.00 73.09 C ATOM 11039 OE1 GLN C 412 52.624 38.590 −51.995 1.00 75.31 O ATOM 11040 NE2 GLN C 412 52.696 36.847 −50.621 1.00 72.30 N ATOM 11041 C GLN C 412 48.586 39.264 −50.246 1.00 63.27 C ATOM 11042 O GLN C 412 49.253 40.128 −49.723 1.00 62.35 O ATOM 11043 N LYS C 413 47.326 39.445 −50.597 1.00 62.93 N ATOM 11044 CA LYS C 413 46.606 40.665 −50.293 1.00 61.89 C ATOM 11045 CB LYS C 413 46.659 41.621 −51.493 1.00 68.00 C ATOM 11046 CG LYS C 413 45.593 41.530 −52.597 1.00 75.00 C ATOM 11047 CD LYS C 413 45.771 40.404 −53.608 1.00 84.90 C ATOM 11048 CE LYS C 413 44.571 39.454 −53.573 1.00 100.96 C ATOM 11049 NZ LYS C 413 44.777 38.150 −54.272 1.00 107.82 N ATOM 11050 C LYS C 413 45.184 40.417 −49.817 1.00 57.19 C ATOM 11051 O LYS C 413 44.631 39.330 −49.980 1.00 51.84 O ATOM 11052 N PHE C 414 44.625 41.446 −49.192 1.00 54.96 N ATOM 11053 CA PHE C 414 43.232 41.457 −48.739 1.00 54.18 C ATOM 11054 CB PHE C 414 42.943 40.422 −47.644 1.00 51.40 C ATOM 11055 CG PHE C 414 43.549 40.725 −46.319 1.00 47.97 C ATOM 11056 CD1 PHE C 414 42.895 41.514 −45.417 1.00 49.55 C ATOM 11057 CE1 PHE C 414 43.423 41.766 −44.159 1.00 49.34 C ATOM 11058 CZ PHE C 414 44.618 41.213 −43.807 1.00 48.75 C ATOM 11059 CE2 PHE C 414 45.274 40.414 −44.713 1.00 48.68 C ATOM 11060 CD2 PHE C 414 44.732 40.172 −45.956 1.00 47.38 C ATOM 11061 C PHE C 414 42.891 42.816 −48.205 1.00 54.46 C ATOM 11062 O PHE C 414 43.789 43.608 −47.958 1.00 56.42 O ATOM 11063 N TRP C 415 41.607 43.065 −47.996 1.00 52.85 N ATOM 11064 CA TRP C 415 41.167 44.359 −47.561 1.00 54.67 C ATOM 11065 CB TRP C 415 40.191 44.937 −48.577 1.00 57.33 C ATOM 11066 CG TRP C 415 40.751 45.576 −49.899 1.00 64.12 C ATOM 11067 CD1 TRP C 415 40.961 46.962 −50.197 1.00 67.17 C ATOM 11068 NE1 TRP C 415 41.403 47.114 −51.496 1.00 64.95 N ATOM 11069 CE2 TRP C 415 41.462 45.862 −52.064 1.00 70.16 C ATOM 11070 CD2 TRP C 415 41.050 44.888 −51.089 1.00 63.96 C ATOM 11071 CE3 TRP C 415 41.040 43.546 −51.435 1.00 67.78 C ATOM 11072 CZ3 TRP C 415 41.434 43.181 −52.754 1.00 81.27 C ATOM 11073 CH2 TRP C 415 41.827 44.155 −53.697 1.00 82.52 C ATOM 11074 CZ2 TRP C 415 41.855 45.499 −53.362 1.00 80.24 C ATOM 11075 C TRP C 415 40.515 44.199 −46.178 1.00 56.94 C ATOM 11076 O TRP C 415 39.828 43.200 −45.910 1.00 54.90 O ATOM 11077 N GLY C 416 40.761 45.168 −45.293 1.00 57.27 N ATOM 11078 CA GLY C 416 40.162 45.214 −43.955 1.00 55.33 C ATOM 11079 C GLY C 416 39.356 46.482 −43.948 1.00 56.47 C ATOM 11080 O GLY C 416 39.948 47.557 −43.995 1.00 61.28 O ATOM 11081 N LEU C 417 38.022 46.361 −43.932 1.00 54.60 N ATOM 11082 CA LEU C 417 37.094 47.488 −44.096 1.00 50.94 C ATOM 11083 CB LEU C 417 36.060 47.179 −45.144 1.00 50.76 C ATOM 11084 CG LEU C 417 36.592 46.593 −46.439 1.00 51.17 C ATOM 11085 CD1 LEU C 417 35.525 45.773 −47.151 1.00 50.29 C ATOM 11086 CD2 LEU C 417 37.124 47.688 −47.331 1.00 51.22 C ATOM 11087 C LEU C 417 36.380 47.745 −42.791 1.00 51.81 C ATOM 11088 O LEU C 417 36.024 46.837 −42.057 1.00 53.19 O ATOM 11089 N THR C 418 36.133 49.004 −42.526 1.00 52.02 N ATOM 11090 CA THR C 418 35.870 49.453 −41.176 1.00 51.55 C ATOM 11091 CB THR C 418 36.644 50.772 −40.866 1.00 52.35 C ATOM 11092 OG1 THR C 418 36.131 51.393 −39.737 1.00 56.03 O ATOM 11093 CG2 THR C 418 36.484 51.857 −41.887 1.00 56.05 C ATOM 11094 C THR C 418 34.365 49.552 −41.073 1.00 51.47 C ATOM 11095 O THR C 418 33.760 50.348 −41.759 1.00 51.53 O ATOM 11096 N ARG C 419 33.772 48.706 −40.228 1.00 53.28 N ATOM 11097 CA ARG C 419 32.305 48.608 −40.013 1.00 50.71 C ATOM 11098 CB ARG C 419 31.956 47.943 −38.668 1.00 52.00 C ATOM 11099 CG ARG C 419 30.482 47.548 −38.506 1.00 54.53 C ATOM 11100 CD ARG C 419 30.131 46.893 −37.162 1.00 56.43 C ATOM 11101 NE ARG C 419 29.940 47.874 −36.092 1.00 61.63 N ATOM 11102 CZ ARG C 419 28.788 48.407 −35.678 1.00 69.97 C ATOM 11103 NH1 ARG C 419 28.811 49.312 −34.695 1.00 73.86 N ATOM 11104 NH2 ARG C 419 27.610 48.054 −36.200 1.00 73.82 N ATOM 11105 C ARG C 419 31.560 49.907 −40.136 1.00 49.04 C ATOM 11106 O ARG C 419 30.663 50.007 −40.937 1.00 49.26 O ATOM 11107 N SER C 420 31.935 50.935 −39.406 1.00 51.24 N ATOM 11108 CA SER C 420 31.127 52.182 −39.465 1.00 54.77 C ATOM 11109 CB SER C 420 31.681 53.248 −38.533 1.00 56.67 C ATOM 11110 OG SER C 420 32.885 53.759 −39.077 1.00 62.18 O ATOM 11111 C SER C 420 30.973 52.819 −40.851 1.00 53.24 C ATOM 11112 O SER C 420 30.024 53.550 −41.094 1.00 51.97 O ATOM 11113 N ALA C 421 31.929 52.555 −41.730 1.00 55.54 N ATOM 11114 CA ALA C 421 31.968 53.146 −43.074 1.00 57.82 C ATOM 11115 CB ALA C 421 33.399 53.171 −43.598 1.00 59.68 C ATOM 11116 C ALA C 421 31.129 52.427 −44.072 1.00 54.71 C ATOM 11117 O ALA C 421 30.968 52.942 −45.170 1.00 51.68 O ATOM 11118 N LEU C 422 30.632 51.255 −43.677 1.00 56.97 N ATOM 11119 CA LEU C 422 29.901 50.339 −44.523 1.00 62.41 C ATOM 11120 CB LEU C 422 30.371 48.921 −44.226 1.00 65.16 C ATOM 11121 CG LEU C 422 31.766 48.638 −44.799 1.00 68.81 C ATOM 11122 CD1 LEU C 422 32.290 47.304 −44.296 1.00 69.74 C ATOM 11123 CD2 LEU C 422 31.768 48.683 −46.331 1.00 67.47 C ATOM 11124 C LEU C 422 28.396 50.399 −44.328 1.00 65.83 C ATOM 11125 O LEU C 422 27.922 50.979 −43.380 1.00 78.90 O ATOM 11126 N LEU C 423 27.647 49.784 −45.231 1.00 67.80 N ATOM 11127 CA LEU C 423 26.196 49.738 −45.150 1.00 68.67 C ATOM 11128 CB LEU C 423 25.629 51.005 −45.784 1.00 71.16 C ATOM 11129 CG LEU C 423 24.215 51.533 −45.490 1.00 72.49 C ATOM 11130 CD1 LEU C 423 23.288 51.391 −46.718 1.00 71.31 C ATOM 11131 CD2 LEU C 423 23.643 50.955 −44.166 1.00 72.52 C ATOM 11132 C LEU C 423 25.694 48.482 −45.856 1.00 73.79 C ATOM 11133 O LEU C 423 25.713 48.435 −47.083 1.00 70.72 O ATOM 11134 N PRO C 424 25.282 47.433 −45.085 1.00 88.28 N ATOM 11135 CA PRO C 424 24.843 46.204 −45.749 1.00 91.80 C ATOM 11136 CB PRO C 424 24.639 45.217 −44.595 1.00 91.55 C ATOM 11137 CG PRO C 424 24.250 46.083 −43.452 1.00 93.55 C ATOM 11138 CD PRO C 424 25.083 47.333 −43.620 1.00 94.39 C ATOM 11139 C PRO C 424 23.549 46.478 −46.466 1.00 94.56 C ATOM 11140 O PRO C 424 22.722 47.221 −45.956 1.00 86.24 O ATOM 11141 N THR C 425 23.374 45.841 −47.611 1.00 107.49 N ATOM 11142 CA THR C 425 22.194 46.023 −48.419 1.00 108.14 C ATOM 11143 CB THR C 425 22.517 46.981 −49.557 1.00 100.65 C ATOM 11144 OG1 THR C 425 23.110 48.156 −49.008 1.00 87.95 O ATOM 11145 CG2 THR C 425 21.263 47.365 −50.253 1.00 106.34 C ATOM 11146 C THR C 425 21.638 44.739 −49.013 1.00 111.97 C ATOM 11147 O THR C 425 22.317 43.733 −49.075 1.00 106.64 O ATOM 11148 N ILE C 426 20.382 44.781 −49.435 1.00 119.03 N ATOM 11149 CA ILE C 426 19.755 43.636 −50.083 1.00 121.37 C ATOM 11150 CB ILE C 426 18.522 43.097 −49.340 1.00 118.00 C ATOM 11151 CG1 ILE C 426 17.382 44.094 −49.361 1.00 116.20 C ATOM 11152 CD1 ILE C 426 16.219 43.638 −48.509 1.00 121.35 C ATOM 11153 CG2 ILE C 426 18.869 42.764 −47.904 1.00 113.87 C ATOM 11154 C ILE C 426 19.464 44.094 −51.504 1.00 112.71 C ATOM 11155 O ILE C 426 18.885 45.144 −51.729 1.00 102.94 O ATOM 11156 N PRO C 427 19.906 43.241 −52.495 1.00 111.44 N ATOM 11157 CA PRO C 427 19.744 43.735 −53.871 1.00 116.12 C ATOM 11158 CB PRO C 427 20.459 42.678 −54.703 1.00 115.01 C ATOM 11159 CG PRO C 427 20.174 41.430 −53.979 1.00 115.80 C ATOM 11160 CD PRO C 427 20.534 41.849 −52.596 1.00 112.68 C ATOM 11161 C PRO C 427 18.382 43.980 −54.493 1.00 115.11 C ATOM 11162 O PRO C 427 17.363 43.432 −54.108 1.00 113.38 O ATOM 11163 N ASP C 428 18.421 44.858 −55.488 1.00 108.40 N ATOM 11164 CA ASP C 428 17.244 45.269 −56.281 1.00 105.21 C ATOM 11165 CB ASP C 428 15.981 44.340 −56.147 1.00 104.41 C ATOM 11166 CG ASP C 428 16.145 42.955 −56.840 1.00 97.39 C ATOM 11167 OD1 ASP C 428 17.063 42.788 −57.675 1.00 92.07 O ATOM 11168 OD2 ASP C 428 15.330 42.041 −56.562 1.00 84.49 O ATOM 11169 C ASP C 428 16.907 46.717 −55.915 1.00 98.25 C ATOM 11170 O ASP C 428 17.141 47.632 −56.707 1.00 86.27 O TER 11171 ASP C 428 HETATM 11172 C22 MOL E 1 52.219 55.861 −30.232 1.00 165.51 C HETATM 11173 C23 MOL E 1 51.226 56.603 −29.327 1.00 173.28 C HETATM 11174 O5 MOL E 1 51.429 58.038 −29.381 1.00 169.11 O HETATM 11175 C24 MOL E 1 51.362 58.545 −30.730 1.00 156.65 C HETATM 11176 C25 MOL E 1 52.393 57.812 −31.594 1.00 158.72 C HETATM 11177 N3 MOL E 1 52.073 56.374 −31.602 1.00 155.78 N HETATM 11178 C21 MOL E 1 52.945 55.643 −32.543 1.00 131.27 C HETATM 11179 C20 MOL E 1 52.372 55.752 −33.967 1.00 104.63 C HETATM 11180 C19 MOL E 1 52.293 54.632 −34.791 1.00 94.32 C HETATM 11181 C17 MOL E 1 51.767 54.754 −36.078 1.00 97.81 C HETATM 11182 C18 MOL E 1 51.925 56.985 −34.439 1.00 100.94 C HETATM 11183 C16 MOL E 1 51.401 57.107 −35.722 1.00 99.76 C HETATM 11184 C15 MOL E 1 51.318 55.991 −36.549 1.00 101.01 C HETATM 11185 C14 MOL E 1 50.789 56.135 −37.841 1.00 93.53 C HETATM 11186 O4 MOL E 1 49.814 55.208 −38.385 1.00 82.82 O HETATM 11187 C3 MOL E 1 48.512 55.568 −38.169 1.00 71.21 C HETATM 11188 C2 MOL E 1 48.154 56.874 −37.858 1.00 69.98 C HETATM 11189 C1 MOL E 1 46.814 57.200 −37.650 1.00 69.30 C HETATM 11190 C4 MOL E 1 45.817 56.235 −37.746 1.00 64.04 C HETATM 11191 C5 MOL E 1 46.165 54.930 −38.064 1.00 69.09 C HETATM 11192 C8 MOL E 1 45.424 53.758 −38.215 1.00 68.74 C HETATM 11193 O1 MOL E 1 44.208 53.673 −38.052 1.00 64.61 O HETATM 11194 C6 MOL E 1 47.505 54.617 −38.264 1.00 70.76 C HETATM 11195 C7 MOL E 1 47.613 53.135 −38.585 1.00 73.04 C HETATM 11196 N1 MOL E 1 46.208 52.721 −38.490 1.00 68.39 N HETATM 11197 C9 MOL E 1 45.746 51.339 −38.642 1.00 63.16 C HETATM 11198 C10 MOL E 1 46.070 50.827 −40.043 1.00 61.46 C HETATM 11199 C11 MOL E 1 45.735 49.342 −40.156 1.00 63.25 C HETATM 11200 C12 MOL E 1 46.446 48.544 −39.064 1.00 62.86 C HETATM 11201 O3 MOL E 1 46.731 47.365 −39.255 1.00 63.54 O HETATM 11202 N2 MOL E 1 46.784 49.144 −37.847 1.00 63.79 N HETATM 11203 C13 MOL E 1 46.470 50.484 −37.594 1.00 64.54 C HETATM 11204 O2 MOL E 1 46.780 50.978 −36.510 1.00 59.72 O HETATM 11205 ZN ZN D 1 31.556 56.746 −50.977 1.00 126.39 ZN END

TABLE 7 Atomic coordinates for CRBN(TBD): Compound B (Murine protein) HEADER - - - - XX-XXX-XX   xxxx COMPND - - - REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.6.0117 REMARK 3 AUTHORS : MURSHUDOV,VAGIN,DODSON REMARK 3 REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS): 2.21 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 REMARK 3 DATA CUTOFF (SIGMA(F)) : NONE REMARK 3 COMPLETENESS FOR RANGE (%) : 99.03 REMARK 3 NUMBER OF REFLECTIONS : 7777 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSSVALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.22404 REMARK 3 R VALUE (WORKING SET) : 0.22296 REMARK 3 FREE R VALUE : 0.24841 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.6 REMARK 3 FREE R VALUETEST SET COUNT : 379 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH : 2.206 REMARK 3 BIN RESOLUTION RANGE LOW : 2.263 REMARK 3 REFLECTION IN BIN (WORKING SET) : 484 REMARK 3 BIN R VALUE (WORKING + TEST) (%) : 98.44 REMARK 3 BIN R VALUE (WORKING SET) : 0.232 REMARK 3 BIN FREE R VALUE SET COUNT : 21 REMARK 3 BIN FREE R VALUE : 0.226 REMARK 3 REMARK 3 NUMBER OF NONHYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 ALL ATOMS : 902 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 43.420 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : −0.57 REMARK 3 B22 (A**2) : −0.57 REMARK 3 B33 (A**2) : 0.85 REMARK 3 B12 (A**2) : −0.28 REMARK 3 B13 (A**2) : 0.00 REMARK 3 B23 (A**2) : 0.00 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A) : 0.233 REMARK 3 ESU BASED ON FREE R VALUE (A) : 0.190 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A) : 0.140 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 9.721 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FOFC : 0.943 REMARK 3 CORRELATION COEFFICIENT FOFC FREE : 0.942 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES  COUNT   RMS   WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A) :    916 ;   0.012 ;   0.019 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES) :  1250 ;   1.637 ;   1.919 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES) :   108 ;   11.923 ;   5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES) :   31 ;   31.950 ;   23.548 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES) :   144 ;   19.557 ;   15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES) : 2 ; 26.606 ; 15.000 REMARK 3 CHIRALCENTER RESTRAINTS (A**3): 136 ; 0.108 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A) : 676 ; 0.018 ; 0.021 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF NCS GROUPS : NULL REMARK 3 REMARK 3 TWIN DETAILS REMARK 3 NUMBER OF TWIN DOMAINS : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 1 REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3 TLS GROUP : 1 REMARK 3 NUMBER OF COMPONENTS GROUP : 1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE : D −10 D 9999 REMARK 3 ORIGIN FOR THE GROUP (A): 24.9839 −14.3091 −7.2602 REMARK 3 T TENSOR REMARK 3 T11: 0.0185 T22: 0.0562 REMARK 3 T33: 0.1037 T12: −0.0004 REMARK 3 T13: 0.0131 T23: −0.0551 REMARK 3 L TENSOR REMARK 3 L11: 0.8932 L22: 1.0237 REMARK 3 L33: 0.9694 L12: −0.1495 REMARK 3 L13: 0.2113 L23: −0.2061 REMARK 3 S TENSOR REMARK 3 S11: 0.0330 S12: −0.0487 S13: 0.0462 REMARK 3 S21: −0.0824 S22: −0.1677 S23: 0.1793 REMARK 3 S31: 0.1011 S32: −0.1109 S33: 0.1347 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT REMARK 3 U VALUES : RESIDUAL ONLY REMARK 3 LINKR CYS D 346   PRO D 348   gap LINKR SER D 344   MET D 349   gap LINKR SER D 344   GLU? D 361   gap CRYST1 75.625   75.625   90.989   90.00   90.00   120.00   P 64 2 2 SCALE1 0.013223   0.007634   0.000000   0.00000 SCALE2 0.000000   0.015269   0.000000   0.00000 SCALE3 0.000000   0.000000   0.010990   0.00000 ATOM 1 N THR D 322 13.672 −7.475 −20.728 1.00 55.10 N ATOM 2 CA THR D 322 14.200 −7.347 −19.335 1.00 60.06 C ATOM 3 CB THR D 322 13.050 −7.203 −18.304 1.00 64.30 C ATOM 4 OG1 THR D 322 12.333 −8.446 −18.191 1.00 62.59 O ATOM 5 CG2 THR D 322 12.088 −6.078 −18.710 1.00 65.54 C ATOM 6 C THR D 322 15.107 −8.534 −18.957 1.00 55.03 C ATOM 7 O THR D 322 15.077 −9.032 −17.831 1.00 53.46 O ATOM 8 N SER D 323 15.912 −8.979 −19.912 1.00 55.16 N ATOM 9 CA SER D 323 16.828 −10.090 −19.702 1.00 55.75 C ATOM 10 CB SER D 323 17.131 −10.771 −21.028 1.00 60.48 C ATOM 11 OG SER D 323 15.947 −11.036 −21.744 1.00 72.98 O ATOM 12 C SER D 323 18.145 −9.584 −19.162 1.00 55.35 C ATOM 13 O SER D 323 18.665 −8.571 −19.651 1.00 56.06 O ATOM 14 N LEU D 324 18.696 −10.301 −18.178 1.00 52.68 N ATOM 15 CA LEU D 324 20.077 −10.068 −17.735 1.00 51.99 C ATOM 16 CB LEU D 324 20.194 −9.944 −16.211 1.00 52.06 C ATOM 17 CG LEU D 324 19.509 −8.747 −15.536 1.00 57.37 C ATOM 18 CD1 LEU D 324 19.826 −8.718 −14.052 1.00 60.77 C ATOM 19 CD2 LEU D 324 19.875 −7.414 −16.175 1.00 61.96 C ATOM 20 C LEU D 324 20.953 −11.183 −18.242 1.00 49.84 C ATOM 21 O LEU D 324 20.694 −12.368 −17.987 1.00 51.57 O ATOM 22 N CYS D 325 21.990 −10.795 −18.977 1.00 46.85 N ATOM 23 CA CYS D 325 22.846 −11.749 −19.666 1.00 46.10 C ATOM 24 CB CYS D 325 22.657 −11.629 −21.184 1.00 49.02 C ATOM 25 SG CYS D 325 23.426 −10.165 −21.913 1.00 60.70 S ATOM 26 C CYS D 325 24.310 −11.564 −19.287 1.00 42.99 C ATOM 27 O CYS D 325 24.696 −10.532 −18.728 1.00 43.59 O ATOM 28 N CYS D 326 25.119 −12.574 −19.575 1.00 40.31 N ATOM 29 CA CYS D 326 26.543 −12.489 −19.361 1.00 39.19 C ATOM 30 CB CYS D 326 27.203 −13.794 −19.740 1.00 38.72 C ATOM 31 SG CYS D 326 28.997 −13.701 −19.671 1.00 41.08 S ATOM 32 C CYS D 326 27.141 −11.334 −20.174 1.00 41.88 C ATOM 33 O CYS D 326 26.911 −11.242 −21.375 1.00 36.63 O ATOM 34 N LYS D 327 27.879 −10.447 −19.500 1.00 42.93 N ATOM 35 CA LYS D 327 28.453 −9.273 −20.145 1.00 45.29 C ATOM 36 CB LYS D 327 29.097 −8.335 −19.128 1.00 43.86 C ATOM 37 CG LYS D 327 30.084 −7.342 −19.737 1.00 46.50 C ATOM 38 CD LYS D 327 29.730 −5.904 −19.397 1.00 46.09 C ATOM 39 CE LYS D 327 30.236 −5.506 −18.025 1.00 50.55 C ATOM 40 NZ LYS D 327 29.270 −4.636 −17.300 1.00 44.51 N ATOM 41 C LYS D 327 29.473 −9.638 −21.224 1.00 50.10 C ATOM 42 O LYS D 327 29.498 −9.025 −22.295 1.00 50.45 O ATOM 43 N GLN D 328 30.313 −10.622 −20.939 1.00 47.77 N ATOM 44 CA GLN D 328 31.357 −11.005 −21.872 1.00 50.83 C ATOM 45 CB GLN D 328 32.446 −11.817 −21.160 1.00 55.48 C ATOM 46 CG GLN D 328 32.938 −13.014 −21.959 1.00 63.92 C ATOM 47 CD GLN D 328 34.450 −13.079 −22.068 1.00 71.71 C ATOM 48 OE1 GLN D 328 35.169 −12.249 −21.500 1.00 82.03 O ATOM 49 NE2 GLN D 328 34.944 −14.062 −22.823 1.00 68.78 N ATOM 50 C GLN D 328 30.823 −11.722 −23.122 1.00 48.23 C ATOM 51 O GLN D 328 31.237 −11.420 −24.230 1.00 51.14 O ATOM 52 N CYS D 329 29.901 −12.660 −22.970 1.00 47.76 N ATOM 53 CA CYS D 329 29.475 −13.403 −24.160 1.00 47.26 C ATOM 54 CB CYS D 329 29.583 −14.920 −23.951 1.00 47.05 C ATOM 55 SG CYS D 329 28.319 −15.712 −22.918 1.00 43.18 S ATOM 56 C CYS D 329 28.137 −12.981 −24.785 1.00 49.59 C ATOM 57 O CYS D 329 27.953 −13.153 −25.987 1.00 52.20 O ATOM 58 N GLN D 330 27.225 −12.422 −23.985 1.00 50.36 N ATOM 59 CA GLN D 330 25.881 −12.010 −24.448 1.00 55.28 C ATOM 60 CB GLN D 330 25.960 −11.017 −25.599 1.00 58.87 C ATOM 61 CG GLN D 330 25.703 −9.583 −25.205 1.00 70.06 C ATOM 62 CD GLN D 330 26.989 −8.839 −24.959 1.00 72.93 C ATOM 63 OE1 GLN D 330 27.182 −7.734 −25.455 1.00 73.11 O ATOM 64 NE2 GLN D 330 27.893 −9.456 −24.212 1.00 76.86 N ATOM 65 C GLN D 330 24.966 −13.135 −24.884 1.00 57.66 C ATOM 66 O GLN D 330 23.834 −12.882 −25.289 1.00 59.24 O ATOM 67 N GLU? D 331 25.442 −14.368 −24.822 1.00 58.30 N ATOM 68 CA GLU? D 331 24.738 −15.452 −25.491 1.00 60.98 C ATOM 69 CB GLU? D 331 25.695 −16.568 −25.838 1.00 58.80 C ATOM 70 CG GLU? D 331 26.536 −16.291 −27.060 1.00 59.50 C ATOM 71 CD GLU? D 331 27.337 −17.508 −27.439 1.00 62.16 C ATOM 72 OE1 GLU? D 331 28.555 −17.360 −27.714 1.00 59.84 O ATOM 73 OE2 GLU? D 331 26.744 −18.618 −27.421 1.00 60.25 O ATOM 74 C GLU? D 331 23.603 −16.045 −24.693 1.00 63.63 C ATOM 75 O GLU? D 331 22.728 −16.703 −25.263 1.00 61.62 O ATOM 76 N THR D 332 23.635 −15.860 −23.380 1.00 57.44 N ATOM 77 CA THR D 332 22.675 −16.538 −22.525 1.00 57.63 C ATOM 78 CB THR D 332 23.376 −17.554 −21.605 1.00 62.66 C ATOM 79 OG1 THR D 332 24.622 −17.002 −21.145 1.00 69.08 O ATOM 80 CG2 THR D 332 23.626 −18.869 −22.353 1.00 63.16 C ATOM 81 C THR D 332 21.939 −15.562 −21.653 1.00 51.94 C ATOM 82 O THR D 332 22.478 −14.538 −21.305 1.00 51.40 O ATOM 83 N GLU? D 333 20.709 −15.906 −21.293 1.00 49.82 N ATOM 84 CA GLU? D 333 19.986 −15.213 −20.244 1.00 53.71 C ATOM 85 CB GLU? D 333 18.487 −15.207 −20.554 1.00 51.89 C ATOM 86 CG GLU? D 333 17.589 −14.979 −19.348 1.00 55.85 C ATOM 87 CD GLU? D 333 16.227 −14.397 −19.707 1.00 64.62 C ATOM 88 OE1 GLU? D 333 16.170 −13.361 −20.405 1.00 64.59 O ATOM 89 OE2 GLU? D 333 15.201 −14.964 −19.272 1.00 67.76 O ATOM 90 C GLU? D 333 20.270 −15.861 −18.883 1.00 50.97 C ATOM 91 O GLU? D 333 19.865 −16.987 −18.643 1.00 54.02 O ATOM 92 N ILE D 334 20.982 −15.156 −18.005 1.00 48.03 N ATOM 93 CA ILE D 334 21.256 −15.671 −16.659 1.00 43.93 C ATOM 94 CB ILE D 334 22.414 −14.918 −15.951 1.00 43.22 C ATOM 95 CG1 ILE D 334 23.753 −15.043 −16.707 1.00 39.78 C ATOM 96 CD1 ILE D 334 23.954 −16.331 −17.461 1.00 41.83 C ATOM 97 CG2 ILE D 334 22.536 −15.367 −14.495 1.00 39.59 C ATOM 98 C ILE D 334 20.014 −15.571 −15.764 1.00 44.49 C ATOM 99 O ILE D 334 19.691 −16.511 −15.052 1.00 41.45 O ATOM 100 N THR D 335 19.356 −14.404 −15.783 1.00 47.71 N ATOM 101 CA THR D 335 18.174 −14.122 −14.950 1.00 47.01 C ATOM 102 CB THR D 335 18.585 −13.724 −13.490 1.00 46.70 C ATOM 103 OG1 THR D 335 17.500 −13.962 −12.589 1.00 50.66 O ATOM 104 CG2 THR D 335 18.971 −12.262 −13.390 1.00 47.13 C ATOM 105 C THR D 335 17.312 −13.017 −15.613 1.00 48.38 C ATOM 106 O THR D 335 17.643 −12.515 −16.694 1.00 47.10 O ATOM 107 N THR D 336 16.212 −12.642 −14.973 1.00 45.55 N ATOM 108 CA THR D 336 15.429 −11.501 −15.450 1.00 48.89 C ATOM 109 CB THR D 336 14.041 −11.921 −15.965 1.00 48.02 C ATOM 110 OG1 THR D 336 13.214 −12.302 −14.862 1.00 51.32 O ATOM 111 CG2 THR D 336 14.153 −13.083 −16.943 1.00 50.95 C ATOM 112 C THR D 336 15.247 −10.485 −14.337 1.00 48.43 C ATOM 113 O THR D 336 15.254 −10.849 −13.156 1.00 47.18 O ATOM 114 N LYS D 337 15.077 −9.217 −14.719 1.00 50.86 N ATOM 115 CA LYS D 337 14.824 −8.141 −13.771 1.00 51.17 C ATOM 116 CB LYS D 337 14.395 −6.868 −14.503 1.00 56.99 C ATOM 117 CG LYS D 337 15.464 −6.306 −15.420 1.00 64.36 C ATOM 118 CD LYS D 337 15.199 −4.850 −15.768 1.00 70.89 C ATOM 119 CE LYS D 337 16.086 −4.422 −16.928 1.00 76.12 C ATOM 120 NZ LYS D 337 16.871 −3.210 −16.572 1.00 72.92 N ATOM 121 C ASN D 338 13.759 −8.562 −12.769 1.00 48.42 C ATOM 122 O ASN D 338 13.821 −8.206 −11.607 1.00 48.74 O ATOM 123 N ASN D 338 12.803 −9.355 −13.230 1.00 52.15 N ATOM 124 CA ASN D 338 11.773 −9.937 −12.381 1.00 52.19 C ATOM 125 CB ASN D 338 10.890 −10.866 −13.217 1.00 62.08 C ATOM 126 CG ASN D 338 9.575 −10.238 −13.572 1.00 66.93 C ATOM 127 OD1 ASN D 338 9.447 −9.014 −13.608 1.00 73.47 O ATOM 128 ND2 ASN D 338 8.580 −11.072 −13.831 1.00 74.44 N ATOM 129 C ASN D 338 12.246 −10.710 −11.1448 1.00 49.72 C ATOM 130 O ASN D 338 11.534 −10.748 −10.145 1.00 41.89 O ATOM 131 N GLU? D 339 13.419 −11.349 −11.221 1.00 48.97 N ATOM 132 CA GLU? D 339 13.862 −12.262 −10.143 1.00 46.62 C ATOM 133 CB GLU? D 339 14.691 −13.405 −10.714 1.00 48.90 C ATOM 134 CG GLU? D 339 13.960 −14.220 −11.763 1.00 54.86 C ATOM 135 CD GLU? D 339 13.057 −15.306 −11.178 1.00 62.15 C ATOM 136 OE1 GLU? D 339 12.878 −15.378 −9.947 1.00 66.09 O ATOM 137 OE2 GLU? D 339 12.519 −16.109 −11.963 1.00 71.69 O ATOM 138 C GLU? D 339 14.653 −11.568 −9.053 1.00 44.83 C ATOM 139 O GLU? D 339 15.026 −12.189 −8.053 1.00 46.84 O ATOM 140 N ILE D 340 14.922 −10.283 −9.249 1.00 42.40 N ATOM 141 CA ILE D 340 15.812 −9.533 −8.361 1.00 40.37 C ATOM 142 CB ILE D 340 16.287 −8.216 −9.023 1.00 39.20 C ATOM 143 CG1 ILE D 340 17.166 −8.491 −10.245 1.00 40.09 C ATOM 144 CD1 ILE D 340 17.382 −7.264 −11.101 1.00 43.03 C ATOM 145 CG2 ILE D 340 17.013 −7.336 −8.021 1.00 37.72 C ATOM 146 C ILE D 340 15.083 −9.191 −7.076 1.00 42.58 C ATOM 147 O ILE D 340 14.002 −8.592 −7.123 1.00 45.17 O ATOM 148 N PHE D 341 15.644 −9.558 −5.926 1.00 41.65 N ATOM 149 CA PHE D 341 15.063 −9.077 −4.688 1.00 42.66 C ATOM 150 CB PHE D 341 14.412 −10.194 −3.856 1.00 53.18 C ATOM 151 CG PHE D 341 15.324 −10.870 −2.885 1.00 57.26 C ATOM 152 CD1 PHE D 341 16.056 −11.991 −3.267 1.00 62.53 C ATOM 153 CE1 PHE D 341 16.873 −12.648 −2.354 1.00 69.00 C ATOM 154 CZ PHE D 341 16.946 −12.198 −1.039 1.00 70.84 C ATOM 155 CE2 PHE D 341 16.208 −11.085 −0.645 1.00 72.90 C ATOM 156 CD2 PHE D 341 15.386 −10.441 −1.562 1.00 64.73 C ATOM 157 C PHE D 341 15.926 −8.115 −3.875 1.00 42.76 C ATOM 158 O PHE D 341 15.478 −7.609 −2.849 1.00 41.40 O ATOM 159 N SER D 342 17.145 −7.848 −4.353 1.00 41.60 N ATOM 160 CA SER D 342 17.962 −6.754 −3.823 1.00 36.63 C ATOM 161 CB SER D 342 18.645 −7.169 −2.525 1.00 39.13 C ATOM 162 OG SER D 342 19.395 −6.088 −1.994 1.00 40.72 O ATOM 163 C SER D 342 18.998 −6.353 −4.849 1.00 36.76 C ATOM 164 O SER D 342 19.571 −7.213 −5.528 1.00 32.26 O ATOM 165 N LEU D 343 19.250 −5.051 −4.950 1.00 34.67 N ATOM 166 CA LEU D 343 20.213 −4.510 −5.908 1.00 37.22 C ATOM 167 CB LEU D 343 19.724 −3.133 −6.407 1.00 38.61 C ATOM 168 CG LEU D 343 18.511 −3.099 −7.359 1.00 40.84 C ATOM 169 CD1 LEU D 343 18.004 −1.680 −7.529 1.00 41.60 C ATOM 170 CD2 LEU D 343 18.890 −3.675 −8.716 1.00 41.46 C ATOM 171 C LEU D 343 21.645 −4.402 −5.333 1.00 38.12 C ATOM 172 O LEU D 343 22.602 −4.175 −6.071 1.00 41.91 O ATOM 173 N SER D 344 21.780 −4.585 −4.021 1.00 36.37 N ATOM 174 CA SER D 344 22.981 −4.203 −3.292 1.00 37.65 C ATOM 175 CB SER D 344 22.841 −2.752 −2.797 1.00 38.80 C ATOM 176 OG SER D 344 23.108 −1.853 −3.840 1.00 43.64 O ATOM 177 C SER D 344 23.124 −5.057 −2.069 1.00 37.13 C ATOM 178 O SER D 344 22.120 −5.490 −1.498 1.00 36.88 O ATOM 179 N LEU D 345 24.359 −5.226 −1.606 1.00 34.29 N ATOM 180 CA LEU D 345 24.596 −5.918 −0.330 1.00 34.20 C ATOM 181 CB LEU D 345 25.628 −7.012 −0.512 1.00 33.97 C ATOM 182 CG LEU D 345 25.154 −8.231 −1.299 1.00 37.95 C ATOM 183 CD1 LEU D 345 26.248 −9.291 −1.308 1.00 37.75 C ATOM 184 CD2 LEU D 345 23.878 −8.799 −0.700 1.00 38.57 C ATOM 185 C LEU D 345 25.098 −4.905 0.661 1.00 36.81 C ATOM 186 O LEU D 345 26.272 −4.531 0.581 1.00 34.68 O ATOM 187 N CYS D 346 24.217 −4.446 1.576 1.00 33.97 N ATOM 188 CA CYS D 346 24.463 −3.261 2.402 1.00 38.44 C ATOM 189 CB CYS D 346 23.227 −2.352 2.404 1.00 38.01 C ATOM 190 SG CYS D 346 22.911 −1.658 0.778 1.00 34.64 S ATOM 191 C CYS D 346 24.901 −3.507 3.856 1.00 43.99 C ATOM 192 O CYS D 346 25.138 −2.549 4.607 1.00 39.75 O ATOM 193 N GLY D 347 25.025 −4.771 4.253 1.00 44.40 N ATOM 194 CA GLY D 347 25.299 −5.092 5.653 1.00 45.93 C ATOM 195 C GLY D 347 26.779 −5.199 5.995 1.00 46.79 C ATOM 196 O GLY D 347 27.609 −4.435 5.467 1.00 47.07 O ATOM 197 N PRO D 348 27.123 −6.156 6.878 1.00 44.92 N ATOM 198 CA PRO D 348 28.504 −6.388 7.298 1.00 49.59 C ATOM 199 CB PRO D 348 28.418 −7.727 8.032 1.00 49.37 C ATOM 200 CG PRO D 348 27.029 −7.764 8.560 1.00 53.70 C ATOM 201 CD PRO D 348 26.196 −7.127 7.486 1.00 49.19 C ATOM 202 C PRO D 348 29.496 −6.489 6.127 1.00 48.81 C ATOM 203 O PRO D 348 30.683 −6.222 6.316 1.00 52.83 O ATOM 204 N MET D 349 29.007 −6.853 4.936 1.00 43.15 N ATOM 205 CA MET D 349 29.872 −7.139 3.781 1.00 41.18 C ATOM 206 CB MET D 349 29.378 −8.417 3.058 1.00 44.97 C ATOM 207 CG MET D 349 28.079 −8.286 2.269 1.00 45.26 C ATOM 208 SD MET D 349 26.553 −7.939 3.171 1.00 48.44 S ATOM 209 CE MET D 349 26.236 −9.477 4.047 1.00 46.69 C ATOM 210 C MET D 349 30.022 −5.966 2.802 1.00 41.48 C ATOM 211 O MET D 349 30.768 −6.049 1.812 1.00 39.74 O ATOM 212 N ALA D 350 29.336 −4.870 3.098 1.00 37.77 N ATOM 213 CA ALA D 350 29.321 −3.672 2.256 1.00 38.84 C ATOM 214 CB ALA D 350 28.498 −2.570 2.918 1.00 35.44 C ATOM 215 C ALA D 350 30.706 −3.131 1.950 1.00 37.71 C ATOM 216 O ALA D 350 30.915 −2.547 0.890 1.00 34.71 O ATOM 217 N ALA D 351 31.647 −3.306 2.867 1.00 34.15 N ATOM 218 CA ALA D 351 33.004 −2.798 2.633 1.00 35.31 C ATOM 219 CB ALA D 351 33.641 −2.362 3.938 1.00 35.21 C ATOM 220 C ALA D 351 33.920 −3.773 1.899 1.00 34.97 C ATOM 221 O ALA D 351 35.053 −3.419 1.537 1.00 34.00 O ATOM 222 N TYR D 352 33.465 −5.001 1.678 1.00 33.17 N ATOM 223 CA TYR D 352 34.368 −6.018 1.138 1.00 30.89 C ATOM 224 CB TYR D 352 33.808 −7.431 1.323 1.00 33.53 C ATOM 225 CG TYR D 352 33.696 −7.859 2.755 1.00 33.55 C ATOM 226 CD1 TYR D 352 34.237 −7.080 3.779 1.00 37.29 C ATOM 227 CE1 TYR D 352 34.140 −7.464 5.095 1.00 37.88 C ATOM 228 CZ TYR D 352 33.490 −8.641 5.400 1.00 37.64 C ATOM 229 OH TYR D 352 33.396 −9.028 6.706 1.00 41.85 O ATOM 230 CE2 TYR D 352 32.962 −9.438 4.416 1.00 34.39 C ATOM 231 CD2 TYR D 352 33.072 −9.042 3.092 1.00 36.66 C ATOM 232 C TYR D 352 34.701 −5.804 −0.322 1.00 33.74 C ATOM 233 O TYR D 352 33.823 −5.413 −1.119 1.00 35.01 O ATOM 234 N VAL D 353 35.969 −6.082 −0.657 1.00 29.98 N ATOM 235 CA VAL D 353 36.518 −6.037 −2.030 1.00 31.48 C ATOM 236 CB VAL D 353 37.477 −4.844 −2.241 1.00 33.99 C ATOM 237 CG1 VAL D 353 37.852 −4.708 −3.724 1.00 34.44 C ATOM 238 CG2 VAL D 353 36.869 −3.534 −1.707 1.00 36.35 C ATOM 239 C VAL D 353 37.337 −7.298 −2.283 1.00 35.11 C ATOM 240 O VAL D 353 38.289 −7.610 −1.548 1.00 34.94 O ATOM 241 N ASN D 354 36.958 −8.025 −3.321 1.00 36.34 N ATOM 242 CA ASN D 354 37.617 −9.247 −3.681 1.00 33.91 C ATOM 243 CB ASN D 354 36.687 −10.417 −3.351 1.00 33.51 C ATOM 244 CG ASN D 354 35.402 −10.347 −4.106 1.00 32.02 C ATOM 245 OD1 ASN D 354 35.335 −9.674 −5.136 1.00 31.31 O ATOM 246 ND2 ASN D 354 34.387 −11.090 −3.652 1.00 27.89 N ATOM 247 C ASN D 354 38.021 −9.173 −5.175 1.00 31.50 C ATOM 248 O ASN D 354 37.840 −8.140 −5.791 1.00 30.41 O ATOM 249 N PRO D 355 38.607 −10.251 −5.746 1.00 33.55 N ATOM 250 CA PRO D 355 39.047 −10.148 −7.134 1.00 33.78 C ATOM 251 CB PRO D 355 39.667 −11.538 −7.404 1.00 36.77 C ATOM 252 CG PRO D 355 40.162 −12.004 −6.051 1.00 31.10 C ATOM 253 CD PRO D 355 39.045 −11.527 −5.131 1.00 35.18 C ATOM 254 C PRO D 355 37.906 −9.874 −8.123 1.00 37.04 C ATOM 255 O PRO D 355 38.164 −9.586 −9.283 1.00 40.58 O ATOM 256 N HIS D 356 36.660 −9.984 −7.676 1.00 35.20 N ATOM 257 CA HIS D 356 35.524 −9.695 −8.529 1.00 33.81 C ATOM 258 CB HIS D 356 34.427 −10.771 −8.308 1.00 34.41 C ATOM 259 CG HIS D 356 34.967 −12.192 −8.302 1.00 32.15 C ATOM 260 ND1 HIS D 356 35.501 −12.766 −9.402 1.00 33.62 N ATOM 261 CE1 HIS D 356 35.942 −14.037 −9.096 1.00 33.26 C ATOM 262 NE2 HIS D 356 35.690 −14.262 −7.781 1.00 32.82 N ATOM 263 CD2 HIS D 356 35.091 −13.114 −7.256 1.00 33.01 C ATOM 264 C HIS D 356 35.015 −8.286 −8.272 1.00 35.75 C ATOM 265 O HIS D 356 33.956 −7.931 −8.748 1.00 35.60 O ATOM 266 N GLY D 357 35.747 −7.461 −7.502 1.00 34.83 N ATOM 267 CA GLY D 357 35.316 −6.054 −7.292 1.00 33.87 C ATOM 268 C GLY D 357 34.536 −5.832 −5.997 1.00 37.52 C ATOM 269 O GLY D 357 34.703 −6.577 −5.035 1.00 38.70 O ATOM 270 N TYR D 358 33.693 −4.808 −5.960 1.00 35.58 N ATOM 271 CA TYR D 358 33.031 −4.434 −4.711 1.00 41.06 C ATOM 272 CB TYR D 358 32.494 −3.008 −4.787 1.00 45.53 C ATOM 273 CG TYR D 358 33.595 −2.005 −4.684 1.00 52.36 C ATOM 274 CD1 TYR D 358 34.183 −1.721 −3.448 1.00 52.81 C ATOM 275 CE1 TYR D 358 35.226 −0.819 −3.345 1.00 54.83 C ATOM 276 CA TYR D 358 35.701 −0.201 −4.485 1.00 54.91 C ATOM 277 OH TYR D 358 36.723 −0.710 −4.371 1.00 69.32 O ATOM 278 CE2 TYR D 358 35.138 −0.458 −5.727 1.00 58.91 C ATOM 279 CD2 TYR D 358 34.090 −1.365 −5.821 1.00 56.33 C ATOM 280 C TYR D 358 31.905 −5.357 −4.354 1.00 36.98 C ATOM 281 O TYR D 358 30.943 −5.438 −5.082 1.00 35.51 O ATOM 282 N VAL D 359 32.003 −6.013 −3.206 1.00 34.40 N ATOM 283 CA VAL D 359 30.945 −6.934 −2.776 1.00 33.37 C ATOM 284 CB VAL D 359 31.317 −7.653 −1.468 1.00 32.59 C ATOM 285 CG1 VAL D 359 30.114 −8.484 −0.957 1.00 31.19 C ATOM 286 CG2 VAL D 359 32.539 −8.539 −1.733 1.00 29.07 C ATOM 287 C VAL D 359 29.577 −6.223 −2.663 1.00 35.54 C ATOM 288 O VAL D 359 28.518 −6.806 −2.911 1.00 33.18 O ATOM 289 N HIS D 360 29.611 −4.946 −2.354 1.00 32.00 N ATOM 290 CA HIS D 360 28.389 −4.172 −2.316 1.00 34.31 C ATOM 291 CB HIS D 360 28.707 −2.716 −2.009 1.00 33.04 C ATOM 292 CG HIS D 360 27.494 −1.841 −1.972 1.00 35.05 C ATOM 293 ND1 HIS D 360 27.142 −1.054 −3.012 1.00 32.98 N ATOM 294 CE1 HIS D 360 26.002 −0.402 −2.702 1.00 35.22 C ATOM 295 NE2 HIS D 360 25.623 −0.784 −1.459 1.00 35.09 N ATOM 296 CD2 HIS D 360 26.514 −1.671 −0.986 1.00 29.00 C ATOM 297 C HIS D 360 27.634 −4.307 −3.617 1.00 34.23 C ATOM 298 O HIS D 360 26.429 −4.516 −3.607 1.00 35.51 O ATOM 299 N GLU? D 361 28.352 −4.296 −4.749 1.00 34.92 N ATOM 300 CA GLU? D 361 27.716 −4.318 −6.094 1.00 32.30 C ATOM 301 CB GLU? D 361 28.625 −3.578 −7.098 1.00 36.49 C ATOM 302 CG GLU? D 361 29.007 −2.159 −6.642 1.00 36.65 C ATOM 303 CD GLU? D 361 27.779 −1.286 −6.402 1.00 41.90 C ATOM 304 OE1 GLU? D 361 27.742 −0.557 −5.385 1.00 41.98 O ATOM 305 OE2 GLU? D 361 26.835 −1.349 −7.229 1.00 44.98 O ATOM 306 C GLU? D 361 27.289 −5.727 −6.591 1.00 35.28 C ATOM 307 O GLU? D 361 27.724 −6.223 −7.666 1.00 33.77 O ATOM 308 N THR D 362 26.464 −6.369 −5.773 1.00 35.76 N ATOM 309 CA THR D 362 25.969 −7.721 −6.004 1.00 37.70 C ATOM 310 CB THR D 362 26.528 −8.682 −4.956 1.00 41.76 C ATOM 311 OG1 THR D 362 27.932 −8.497 −4.868 1.00 41.20 O ATOM 312 CG2 THR D 362 26.217 −10.170 −5.291 1.00 37.69 C ATOM 313 C THR D 362 24.442 −7.736 −5.872 1.00 39.83 C ATOM 314 O THR D 362 23.886 −7.254 −4.857 1.00 36.64 O ATOM 315 N LEU D 363 23.791 −8.273 −6.909 1.00 36.29 N ATOM 316 CA LEU D 363 22.342 −8.508 −6.964 1.00 36.95 C ATOM 317 CB LEU D 363 21.927 −8.748 −8.426 1.00 35.28 C ATOM 318 CG LEU D 363 21.385 −7.651 −9.312 1.00 37.37 C ATOM 319 CD1 LEU D 363 21.771 −6.251 −8.852 1.00 36.72 C ATOM 320 CD2 LEU D 363 21.821 −7.913 −10.740 1.00 34.13 C ATOM 321 C LEU D 363 22.013 −9.783 −6.225 1.00 40.43 C ATOM 322 O LEU D 363 22.779 −10.748 −6.305 1.00 44.36 O ATOM 323 N THR D 364 20.871 −9.826 −5.541 1.00 37.95 N ATOM 324 CA THR D 364 20.370 −11.099 −5.034 1.00 40.03 C ATOM 325 CB THR D 364 20.140 −11.092 −3.516 1.00 40.52 C ATOM 326 OG1 THR D 364 19.181 −10.089 −3.203 1.00 58.15 O ATOM 327 CG2 THR D 364 21.403 −10.775 −2.803 1.00 43.74 C ATOM 328 C THR D 364 19.085 −11.438 −5.782 1.00 39.43 C ATOM 329 O THR D 364 18.166 −10.626 −5.848 1.00 37.48 O ATOM 330 N VAL D 365 19.065 −12.615 −6.397 1.00 37.36 N ATOM 331 CA VAL D 365 17.980 −13.021 −7.257 1.00 37.39 C ATOM 332 CB VAL D 365 18.388 −13.006 −8.759 1.00 38.96 C ATOM 333 CG1 VAL D 365 19.146 −11.729 −9.074 1.00 41.95 C ATOM 334 CG2 VAL D 365 19.262 −14.187 −9.131 1.00 39.31 C ATOM 335 C VAL D 365 17.472 −14.371 −6.812 1.00 37.49 C ATOM 336 O VAL D 365 18.209 −15.138 −6.198 1.00 34.12 O ATOM 337 N TYR D 366 16.186 −14.633 −7.066 1.00 41.73 N ATOM 338 CA TYR D 366 15.564 −15.911 −6.728 1.00 41.31 C ATOM 339 CB TYR D 366 14.045 −15.802 −6.795 1.00 48.43 C ATOM 340 CG TYR D 366 13.453 −14.932 −5.738 1.00 46.52 C ATOM 341 CD1 TYR D 366 13.550 −15.277 −4.390 1.00 49.31 C ATOM 342 CE1 TYR D 366 12.991 −14.477 −3.410 1.00 53.15 C ATOM 343 CZ TYR D 366 12.315 −13.326 −3.785 1.00 53.40 C ATOM 344 OH TYR D 366 11.768 −12.521 −2.831 1.00 59.53 O ATOM 345 CE2 TYR D 366 12.202 −12.966 −5.111 1.00 52.37 C ATOM 346 CD2 TYR D 366 12.778 −13.767 −6.081 1.00 49.58 C ATOM 347 C TYR D 366 15.985 −17.071 −7.614 1.00 37.88 C ATOM 348 O TYR D 366 16.056 −18.194 −7.152 1.00 37.98 O ATOM 349 N LYS D 367 16.227 −16.803 −8.885 1.00 39.35 N ATOM 350 CA LYS D 367 16.515 −17.853 −9.850 1.00 42.45 C ATOM 351 CB LYS D 367 15.247 −18.249 −10.610 1.00 47.41 C ATOM 352 CG LYS D 367 14.501 −19.412 −10.004 1.00 55.96 C ATOM 353 CD LYS D 367 13.025 −19.362 −10.355 1.00 59.54 C ATOM 354 CE LYS D 367 12.238 −20.254 −9.408 1.00 59.93 C ATOM 355 NZ LYS D 367 10.780 −20.050 −9.600 1.00 64.09 N ATOM 356 C LYS D 367 17.488 −17.314 −10.850 1.00 41.59 C ATOM 357 O LYS D 367 17.423 −16.142 −11.212 1.00 38.46 O ATOM 358 N ALA D 368 18.384 −18.180 −11.297 1.00 39.65 N ATOM 359 CA ALA D 368 19.311 −17.870 −12.381 1.00 39.60 C ATOM 360 CB ALA D 368 20.649 −17.404 −11.820 1.00 37.21 C ATOM 361 C ALA D 368 19.489 −19.174 −13.087 1.00 38.56 C ATOM 362 O ALA D 368 19.334 −20.214 −12.480 1.00 43.24 O ATOM 363 N SER D 369 19.832 −19.149 −14.356 1.00 40.49 N ATOM 364 CA SER D 369 20.224 −20.388 −15.015 1.00 42.25 C ATOM 365 CB SER D 369 19.043 −20.939 −15.798 1.00 45.22 C ATOM 366 OG SER D 369 18.521 −19.910 −16.598 1.00 48.44 O ATOM 367 C SER D 369 21.394 −20.113 −15.938 1.00 40.57 C ATOM 368 O SER D 369 21.865 −18.974 −16.021 1.00 41.30 O ATOM 369 N ASN D 370 21.838 −21.150 −16.638 1.00 37.10 N ATOM 370 CA ASN D 370 22.961 −21.072 −17.585 1.00 38.54 C ATOM 371 CB ASN D 370 22.675 −20.083 −18.714 1.00 36.89 C ATOM 372 CG ASN D 370 21.498 −20.523 −19.575 1.00 44.46 C ATOM 373 OD1 ASN D 370 20.618 −19.724 −19.891 1.00 46.79 O ATOM 374 ND2 ASN D 370 21.458 −21.801 −19.929 1.00 43.86 N ATOM 375 C ASN D 370 24.329 −20.828 −16.960 1.00 35.25 C ATOM 376 O ASN D 370 25.214 −20.228 −17.583 1.00 36.57 O ATOM 377 N LEU D 371 24.484 −21.331 −15.742 1.00 33.74 N ATOM 378 CA LEU D 371 25.664 −21.133 −14.908 1.00 34.91 C ATOM 379 CB LEU D 371 25.224 −20.452 −13.609 1.00 31.20 C ATOM 380 CG LEU D 371 24.705 −19.026 −13.788 1.00 34.14 C ATOM 381 CD1 LEU D 371 24.271 −18.387 −12.469 1.00 34.93 C ATOM 382 CD2 LEU D 371 25.763 −18.163 −14.428 1.00 30.61 C ATOM 383 C LEU D 371 26.235 −22.489 −14.580 1.00 34.53 C ATOM 384 O LEU D 371 25.484 −23.420 −14.366 1.00 39.51 O ATOM 385 N ASN D 372 27.550 −22.630 −14.588 1.00 35.09 N ATOM 386 CA ASN D 372 28.174 −23.846 −14.082 1.00 34.71 C ATOM 387 CB ASN D 372 29.463 −24.170 −14.855 1.00 33.95 C ATOM 388 CG ASN D 372 29.204 −24.930 −16.157 1.00 32.71 C ATOM 389 OD1 ASN D 372 28.227 −25.648 −16.276 1.00 31.70 O ATOM 390 ND2 ASN D 372 30.078 −24.763 −17.126 1.00 31.04 N ATOM 391 C ASN D 372 28.522 −23.594 −12.620 1.00 37.24 C ATOM 392 O ASN D 372 28.977 −22.506 −12.269 1.00 33.78 O ATOM 393 N LEU D 373 28.315 −24.592 −11.770 1.00 37.90 N ATOM 394 CA LEU D 373 28.715 −24.474 −10.353 1.00 36.96 C ATOM 395 CB LEU D 373 27.639 −25.039 −9.426 1.00 34.06 C ATOM 396 CG LEU D 373 26.225 −24.418 −9.508 1.00 37.03 C ATOM 397 CD1 LEU D 373 25.176 −25.200 −8.709 1.00 36.31 C ATOM 398 CD2 LEU D 373 26.225 −22.949 −9.085 1.00 36.31 C ATOM 399 C LEU D 373 30.056 −25.149 −10.152 1.00 37.16 C ATOM 400 O LEU D 373 30.275 −26.259 −10.640 1.00 39.83 O ATOM 401 N ILE D 374 30.968 −24.452 −9.488 1.00 35.93 N ATOM 402 CA ILE D 374 32.318 −24.956 −9.239 1.00 36.73 C ATOM 403 CB ILE D 374 33.392 −23.933 −9.672 1.00 39.27 C ATOM 404 CG1 ILE D 374 33.048 −23.222 −11.004 1.00 40.22 C ATOM 405 CD1 ILE D 374 32.856 −24.144 −12.184 1.00 40.74 C ATOM 406 CG2 ILE D 374 34.771 −24.558 −9.670 1.00 42.35 C ATOM 407 C ILE D 374 32.523 −25.202 −7.748 1.00 38.26 C ATOM 408 O ILE D 374 32.465 −24.262 −6.950 1.00 39.25 O ATOM 409 N GLY D 375 32.771 −26.453 −7.378 1.00 36.61 N ATOM 410 CA GLY D 375 33.059 −26.827 −5.991 1.00 39.66 C ATOM 411 C GLY D 375 31.859 −27.338 −5.205 1.00 42.80 C ATOM 412 O GLY D 375 30.754 −27.469 −5.738 1.00 40.54 O ATOM 413 N ARG D 376 32.095 −27.649 −3.935 1.00 43.08 N ATOM 414 CA ARG D 376 31.050 −28.018 −2.992 1.00 44.29 C ATOM 415 CB ARG D 376 31.598 −29.073 −2.006 1.00 50.84 C ATOM 416 CG ARG D 376 31.730 −30.485 −2.569 1.00 59.41 C ATOM 417 CD ARG D 376 30.389 −31.236 −2.555 1.00 69.31 C ATOM 418 NE ARG D 376 30.362 −32.513 −3.304 1.00 78.56 N ATOM 419 CZ ARG D 376 31.369 −33.390 −3.405 1.00 79.37 C ATOM 420 NH1 ARG D 376 32.529 −33.167 −2.796 1.00 73.26 N ATOM 421 NH2 ARG D 376 31.210 −34.506 −4.118 1.00 78.15 N ATOM 422 C ARG D 376 30.643 −26.750 −2.228 1.00 39.46 C ATOM 423 O ARG D 376 31.475 −25.872 −2.012 1.00 43.83 O ATOM 424 N PRO D 377 29.376 −26.644 −1.799 1.00 39.18 N ATOM 425 CA PRO D 377 28.999 −25.446 −1.012 1.00 36.85 C ATOM 426 CB PRO D 377 27.574 −25.777 −0.539 1.00 36.38 C ATOM 427 CG PRO D 377 27.068 −26.825 −1.491 1.00 37.82 C ATOM 428 CD PRO D 377 28.291 −27.650 −1.809 1.00 39.22 C ATOM 429 C PRO D 377 29.921 −25.243 0.199 1.00 34.83 C ATOM 430 O PRO D 377 30.331 −26.213 0.803 1.00 38.01 O ATOM 431 N SER D 378 30.261 −24.000 0.533 1.00 33.49 N ATOM 432 CA SER D 378 31.112 −23.726 1.695 1.00 32.07 C ATOM 433 CB SER D 378 32.481 −23.222 1.209 1.00 33.70 C ATOM 434 OG SER D 378 33.272 −22.803 2.310 1.00 38.53 O ATOM 435 C SER D 378 30.451 −22.699 2.608 1.00 33.15 C ATOM 436 O SER D 378 29.805 −21.758 2.124 1.00 34.08 O ATOM 437 N THR D 379 30.551 −22.891 3.921 1.00 32.45 N ATOM 438 CA THR D 379 30.063 −21.883 4.859 1.00 35.64 C ATOM 439 CB THR D 379 29.446 −22.493 6.132 1.00 38.35 C ATOM 440 OG1 THR D 379 30.425 −23.336 6.748 1.00 39.57 O ATOM 441 CG2 THR D 379 28.163 −23.311 5.812 1.00 35.73 C ATOM 442 C THR D 379 31.160 −20.921 5.321 1.00 36.20 C ATOM 443 O THR D 379 30.853 −19.907 5.942 1.00 35.85 O ATOM 444 N VAL D 380 32.429 −21.217 5.038 1.00 36.69 N ATOM 445 CA VAL D 380 33.520 −20.286 5.452 1.00 35.32 C ATOM 446 CB VAL D 380 34.907 −20.834 5.066 1.00 35.62 C ATOM 447 CG1 VAL D 380 36.019 −19.926 5.595 1.00 35.88 C ATOM 448 CG2 VAL D 380 35.062 −22.214 5.659 1.00 33.88 C ATOM 449 C VAL D 380 33.303 −18.841 4.952 1.00 32.73 C ATOM 450 O VAL D 380 33.172 −18.594 3.763 1.00 35.46 O ATOM 451 N HIS D 381 33.190 −17.902 5.891 1.00 31.84 N ATOM 452 CA HIS D 381 32.978 −16.487 5.582 1.00 32.06 C ATOM 453 CB HIS D 381 34.218 −15.871 4.903 1.00 32.91 C ATOM 454 CG HIS D 381 35.481 −15.854 5.770 1.00 32.96 C ATOM 455 ND1 HIS D 381 35.479 −15.452 7.066 1.00 35.59 N ATOM 456 CE1 HIS D 381 36.756 −15.510 7.565 1.00 35.85 C ATOM 457 NE2 HIS D 381 37.590 −15.919 6.558 1.00 31.51 N ATOM 458 CD2 HIS D 381 36.841 −16.141 5.445 1.00 37.26 C ATOM 459 C HIS D 381 31.749 −16.233 4.746 1.00 34.61 C ATOM 460 O HIS D 381 31.709 −15.280 3.954 1.00 31.70 O ATOM 461 N SER D 382 30.711 −17.064 4.899 1.00 34.29 N ATOM 462 CA SER D 382 29.481 −16.835 4.144 1.00 32.01 C ATOM 463 CB SER D 382 28.421 −17.878 4.476 1.00 31.79 C ATOM 464 OG SER D 382 27.241 −17.553 3.755 1.00 33.80 O ATOM 465 C SER D 382 28.928 −15.426 4.408 1.00 33.44 C ATOM 466 O SER D 382 28.932 −14.971 5.544 1.00 32.57 O ATOM 467 N TRP D 383 28.456 −14.728 3.374 1.00 34.23 N ATOM 468 CA TRP D 383 27.835 −13.422 3.631 1.00 35.12 C ATOM 469 CB TRP D 383 27.711 −12.616 2.362 1.00 31.98 C ATOM 470 CG TRP D 383 29.009 −12.338 1.666 1.00 34.15 C ATOM 471 CD1 TRP D 383 30.259 −12.059 2.236 1.00 33.46 C ATOM 472 NE1 TRP D 383 31.206 −11.853 1.247 1.00 31.44 N ATOM 473 CE2 TRP D 383 30.632 −11.955 0.022 1.00 33.83 C ATOM 474 CD2 TRP D 383 29.211 −12.261 0.230 1.00 31.29 C ATOM 475 CE3 TRP D 383 28.392 −12.427 −0.864 1.00 34.28 C ATOM 476 CZ3 TRP D 383 28.957 −12.287 −2.140 1.00 35.89 C ATOM 477 CH2 TRP D 383 30.307 −12.007 −2.316 1.00 33.47 C ATOM 478 CZ2 TRP D 383 31.177 −11.839 −1.242 1.00 33.32 C ATOM 479 C TRP D 383 26.469 −13.529 4.267 1.00 38.94 C ATOM 480 O TRP D 383 25.943 −12.538 4.781 1.00 34.44 O ATOM 481 N PHE D 384 25.850 −14.698 4.195 1.00 38.99 N ATOM 482 CA PHE D 384 24.489 −14.849 4.722 1.00 38.88 C ATOM 483 CB PHE D 384 23.496 −15.090 3.576 1.00 37.96 C ATOM 484 CG PHE D 384 23.478 −13.994 2.546 1.00 42.43 C ATOM 485 CD1 PHE D 384 22.687 −12.858 2.728 1.00 44.37 C ATOM 486 CE1 PHE D 384 22.669 −11.844 1.775 1.00 43.34 C ATOM 487 CZ PHE D 384 23.451 −11.957 0.634 1.00 45.17 C ATOM 488 CE2 PHE D 384 24.242 −13.083 0.447 1.00 41.11 C ATOM 489 CD2 PHE D 384 24.240 −14.095 1.387 1.00 39.47 C ATOM 490 C PHE D 384 24.502 −16.032 5.666 1.00 39.96 C ATOM 491 O PHE D 384 24.377 −17.166 5.213 1.00 40.65 O ATOM 492 N PRO D 385 24.709 −15.782 6.974 1.00 43.72 N ATOM 493 CA PRO D 385 24.856 −16.883 7.926 1.00 45.44 C ATOM 494 CB PRO D 385 24.890 −16.169 9.282 1.00 48.76 C ATOM 495 CG PRO D 385 25.502 −14.838 8.960 1.00 48.53 C ATOM 496 CD PRO D 385 24.856 −14.473 7.642 1.00 46.37 C ATOM 497 C PRO D 385 23.684 −17.865 7.838 1.00 45.59 C ATOM 498 O PRO D 385 22.535 −17.450 7.676 1.00 41.55 O ATOM 499 N GLY D 386 24.011 −19.157 7.882 1.00 43.27 N ATOM 500 CA GLY D 386 23.053 −20.233 7.683 1.00 40.86 C ATOM 501 C GLY D 386 22.961 −20.714 6.250 1.00 39.65 C ATOM 502 O GLY D 386 22.235 −21.676 5.961 1.00 35.59 O ATOM 503 N TYR D 387 23.625 −19.995 5.343 1.00 36.22 N ATOM 504 CA TYR D 387 23.713 −20.396 3.930 1.00 35.77 C ATOM 505 CB TYR D 387 23.211 −19.270 2.994 1.00 34.92 C ATOM 506 CG TYR D 387 21.746 −19.073 3.038 1.00 37.77 C ATOM 507 CD1 TYR D 387 20.911 −19.807 2.202 1.00 37.84 C ATOM 508 CE1 TYR D 387 19.555 −19.655 2.245 1.00 41.24 C ATOM 509 CZ TYR D 387 18.994 −18.762 3.152 1.00 43.55 C ATOM 510 OH TYR D 387 17.615 −18.617 3.183 1.00 42.93 O ATOM 511 CE2 TYR D 387 19.799 −18.011 3.997 1.00 40.40 C ATOM 512 CD2 TYR D 387 21.176 −18.173 3.934 1.00 38.33 C ATOM 513 C TYR D 387 25.141 −20.713 3.570 1.00 34.68 C ATOM 514 O TYR D 387 26.075 −20.042 4.051 1.00 37.38 O ATOM 515 N ALA D 388 25.313 −21.691 2.685 1.00 33.11 N ATOM 516 CA ALA D 388 26.621 −21.984 2.084 1.00 36.22 C ATOM 517 CB ALA D 388 26.884 −23.495 2.092 1.00 36.42 C ATOM 518 C ALA D 388 26.654 −21.438 0.660 1.00 32.65 C ATOM 519 O ALA D 388 25.597 −21.287 0.036 1.00 35.53 O ATOM 520 N TRP D 389 27.848 −21.151 0.146 1.00 32.91 N ATOM 521 CA TRP D 389 28.015 −20.560 −1.191 1.00 32.32 C ATOM 522 CB TRP D 389 28.688 −19.181 −1.085 1.00 30.82 C ATOM 523 CG TRP D 389 29.981 −19.160 −0.290 1.00 30.29 C ATOM 524 CD1 TRP D 389 30.148 −18.845 1.055 1.00 30.87 C ATOM 525 NE1 TRP D 389 31.470 −18.925 1.411 1.00 29.58 N ATOM 526 CE2 TRP D 389 32.226 −19.269 0.352 1.00 31.08 C ATOM 527 CD2 TRP D 389 31.329 −19.419 −0.789 1.00 28.42 C ATOM 528 CE3 TRP D 389 31.858 −19.785 −2.027 1.00 30.50 C ATOM 529 CZ3 TRP D 389 33.247 −19.972 −2.135 1.00 32.88 C ATOM 530 CH2 TRP D 389 34.100 −19.794 −1.023 1.00 31.66 C ATOM 531 CZ2 TRP D 389 33.610 −19.458 0.242 1.00 31.85 C ATOM 532 C TRP D 389 28.796 −21.427 2.135 1.00 33.16 C ATOM 533 O TRP D 389 29.711 −22.144 −1.735 1.00 32.77 O ATOM 534 N THR D 390 28.463 −21.355 −3.413 1.00 34.00 N ATOM 535 CA THR D 390 29.249 −22.053 −4.436 1.00 34.64 C ATOM 536 CB THR D 390 28.508 −23.307 −4.949 1.00 33.33 C ATOM 537 OG1 THR D 390 28.116 −24.103 −3.832 1.00 33.41 O ATOM 538 CG2 THR D 390 29.412 −24.133 −5.861 1.00 32.88 C ATOM 539 C THR D 390 29.493 −21.120 −5.602 1.00 33.95 C ATOM 540 O THR D 390 28.561 −20.464 −6.062 1.00 32.10 O ATOM 541 N ILE D 391 30.737 −21.043 −6.071 1.00 33.47 N ATOM 542 CA ILE D 391 31.087 −20.121 −7.135 1.00 33.01 C ATOM 543 CB ILE D 391 32.606 −20.144 −7.432 1.00 34.39 C ATOM 544 CG1 ILE D 391 33.361 −19.302 −6.389 1.00 36.06 C ATOM 545 CD1 ILE D 391 34.776 −19.786 −6.120 1.00 34.24 C ATOM 546 CG2 ILE D 391 32.902 −19.578 −8.825 1.00 33.97 C ATOM 547 C ILE D 391 30.278 −20.501 −8.380 1.00 37.87 C ATOM 548 O ILE D 391 30.084 −21.699 −8.654 1.00 35.49 O ATOM 549 N ALA D 392 29.803 −19.498 −9.126 1.00 32.41 N ATOM 550 CA ALA D 392 29.001 −19.767 −10.334 1.00 34.27 C ATOM 551 CB ALA D 392 27.520 −19.451 −10.098 1.00 31.15 C ATOM 552 C ALA D 392 29.545 −18.999 −11.537 1.00 34.93 C ATOM 553 O ALA D 392 29.826 −17.796 −11.447 1.00 35.86 O ATOM 554 N GLN D 393 29.750 −19.717 −12.645 1.00 35.74 N ATOM 555 CA GLN D 393 30.371 −19.151 −13.841 1.00 34.38 C ATOM 556 CB GLN D 393 31.771 −19.753 −14.018 1.00 35.51 C ATOM 557 CG GLN D 393 32.717 −19.230 −12.959 1.00 37.26 C ATOM 558 CD GLN D 393 34.109 −19.856 −12.981 1.00 41.66 C ATOM 559 OE1 GLN D 393 34.992 −19.391 −12.256 1.00 42.29 O ATOM 560 NE2 GLN D 393 34.312 −20.903 −13.789 1.00 35.80 N ATOM 561 C GLN D 393 29.522 −19.408 −15.077 1.00 35.24 C ATOM 562 O GLN D 393 28.816 −20.416 −15.131 1.00 35.93 O ATOM 563 N CYS D 394 29.602 −18.496 −16.062 1.00 34.04 N ATOM 564 CA CYS D 394 28.857 −18.599 −17.314 1.00 31.09 C ATOM 565 CB CYS D 394 29.263 −17.465 −18.264 1.00 32.23 C ATOM 566 SG CYS D 394 28.391 −17.420 −19.869 1.00 39.18 S ATOM 567 C CYS D 394 29.189 −19.922 −17.959 1.00 33.67 C ATOM 568 O CYS D 394 30.372 −20.245 −18.113 1.00 29.95 O ATOM 569 N LYS D 395 28.163 −20.691 −18.338 1.00 34.37 N ATOM 570 CA LYS D 395 28.411 −22.011 −18.933 1.00 41.50 C ATOM 571 CB LYS D 395 27.182 −22.952 −18.839 1.00 45.54 C ATOM 572 CG LYS D 395 26.122 −22.791 −19.905 1.00 47.12 C ATOM 573 CD LYS D 395 24.937 −23.739 −19.661 1.00 49.98 C ATOM 574 CE LYS D 395 23.863 −23.555 −20.749 1.00 53.69 C ATOM 575 NZ LYS D 395 22.586 −24.319 −20.540 1.00 50.24 N ATOM 576 C LYS D 395 28.966 −21.894 −20.349 1.00 42.42 C ATOM 577 O LYS D 395 29.616 −22.814 −20.837 1.00 44.12 O ATOM 578 N ILE D 396 28.764 −20.735 −20.974 1.00 42.06 N ATOM 579 CA ILE D 396 29.261 −20.491 −22.331 1.00 42.15 C ATOM 580 CB ILE D 396 28.384 −19.482 −23.109 1.00 43.00 C ATOM 581 CG1 ILE D 396 26.926 −19.984 −23.235 1.00 41.49 C ATOM 582 CD1 ILE D 396 26.759 −21.455 −23.591 1.00 43.33 C ATOM 583 CG2 ILE D 396 28.999 −19.182 −24.467 1.00 43.69 C ATOM 584 C ILE D 396 30.731 −20.059 −22.374 1.00 42.04 C ATOM 585 O ILE D 396 31.530 −20.640 −23.119 1.00 38.64 O ATOM 586 N CYS D 397 31.084 −19.040 −21.589 1.00 39.02 N ATOM 587 CA CYS D 397 32.433 −18.471 −21.642 1.00 37.29 C ATOM 588 CB CYS D 397 32.367 −16.984 −22.041 1.00 38.27 C ATOM 589 SG CYS D 397 31.705 −15.879 −20.761 1.00 37.94 S ATOM 590 C CYS D 397 33.272 −18.628 −20.361 1.00 38.44 C ATOM 591 O CYS D 397 34.394 −18.116 −20.304 1.00 37.89 O ATOM 592 N ALA D 398 32.740 −19.323 −19.346 1.00 32.84 N ATOM 593 CA ALA D 398 33.430 −19.503 −18.036 1.00 33.52 C ATOM 594 CB ALA D 398 34.680 −20.374 −18.178 1.00 30.64 C ATOM 595 C ALA D 398 33.778 −18.191 −17.294 1.00 33.76 C ATOM 596 O ALA D 398 34.530 −18.198 −16.327 1.00 36.76 O ATOM 597 N SER D 399 33.233 −17.062 −17.706 1.00 34.22 N ATOM 598 CA SER D 399 33.563 −15.878 −16.961 1.00 38.18 C ATOM 599 CB SER D 399 33.417 −14.599 −17.809 1.00 42.95 C ATOM 600 OG SER D 399 32.099 −14.121 −17.775 1.00 50.88 O ATOM 601 C SER D 399 32.796 −15.858 −15.609 1.00 39.23 C ATOM 602 O SER D 399 31.726 −16.507 −15.449 1.00 38.31 O ATOM 603 N HIS D 400 33.393 −15.191 −14.620 1.00 36.83 N ATOM 604 CA HIS D 400 32.762 −15.067 −13.323 1.00 35.18 C ATOM 605 CB HIS D 400 33.591 −14.214 −12.413 1.00 34.42 C ATOM 606 CG HIS D 400 32.891 −13.910 −11.129 1.00 33.73 C ATOM 607 ND1 HIS D 400 32.704 −14.838 −10.188 1.00 34.26 N ATOM 608 CE1 HIS D 400 32.003 −14.312 −9.167 1.00 31.11 C ATOM 609 NE2 HIS D 400 31.767 −13.035 −9.447 1.00 33.25 N ATOM 610 CD2 HIS D 400 32.276 −12.755 −10.673 1.00 34.61 C ATOM 611 C HIS D 400 31.392 −14.462 −13.420 1.00 34.30 C ATOM 612 O HIS D 400 31.220 −13.426 −14.040 1.00 31.33 O ATOM 613 N ILE D 401 30.403 −15.095 −12.796 1.00 31.58 N ATOM 614 CA ILE D 401 29.085 −14.479 −12.702 1.00 31.70 C ATOM 615 CB ILE D 401 28.001 −15.369 −13.367 1.00 34.13 C ATOM 616 CG1 ILE D 401 28.245 −15.536 −14.887 1.00 31.21 C ATOM 617 CD1 ILE D 401 28.050 −14.243 −15.677 1.00 34.84 C ATOM 618 CG2 ILE D 401 26.602 −14.823 −13.073 1.00 34.61 C ATOM 619 C ILE D 401 28.679 −14.165 −11.235 1.00 31.39 C ATOM 620 O ILE D 401 28.111 −13.103 −10.950 1.00 31.52 O ATOM 621 N GLY D 402 28.954 −15.080 −10.313 1.00 29.37 N ATOM 622 CA GLY D 402 28.449 −14.910 −8.945 1.00 31.30 C ATOM 623 C GLY D 402 28.556 −16.148 −8.114 1.00 32.12 C ATOM 624 O GLY D 402 29.518 −16.885 −8.261 1.00 34.75 O ATOM 625 N TRP D 403 27.600 −16.340 −7.198 1.00 31.94 N ATOM 626 CA TRP D 403 27.563 −17.476 −6.280 1.00 31.38 C ATOM 627 CB TRP D 403 28.156 −17.120 −4.896 1.00 30.77 C ATOM 628 CG TRP D 403 29.554 −16.505 −4.998 1.00 29.59 C ATOM 629 CD1 TRP D 403 30.758 −17.140 −4.867 1.00 29.27 C ATOM 630 NE1 TRP D 403 31.818 −16.247 −5.068 1.00 26.94 N ATOM 631 CE2 TRP D 403 31.336 −15.008 −5.356 1.00 30.23 C ATOM 632 CD2 TRP D 403 29.883 −15.097 −5.318 1.00 28.99 C ATOM 633 CE3 TRP D 403 29.132 −13.950 −5.564 1.00 30.63 C ATOM 634 CZ3 TRP D 403 29.812 −12.731 −5.856 1.00 30.71 C ATOM 635 CH2 TRP D 403 31.209 −12.666 −5.882 1.00 28.58 C ATOM 636 CZ2 TRP D 403 32.002 −13.800 −5.636 1.00 32.44 C ATOM 637 C TRP D 403 26.143 −17.955 −6.098 1.00 36.21 C ATOM 638 O TRP D 403 25.220 −17.147 −6.071 1.00 39.69 O ATOM 639 N LYS D 404 25.965 −19.269 −5.948 1.00 32.03 N ATOM 640 CA LYS D 404 24.699 −19.832 −5.492 1.00 32.64 C ATOM 641 CB LYS D 404 24.404 −21.136 −6.212 1.00 34.16 C ATOM 642 CG LYS D 404 23.037 −21.734 −5.920 1.00 34.90 C ATOM 643 CD LYS D 404 22.876 −23.068 −6.624 1.00 33.57 C ATOM 644 CE LYS D 404 21.507 −23.678 −6.343 1.00 38.06 C ATOM 645 NZ LYS D 404 21.367 −24.924 −7.135 1.00 36.03 N ATOM 646 C LYS D 404 24.812 −20.100 −4.014 1.00 32.19 C ATOM 647 O LYS D 404 25.830 −20.654 −3.543 1.00 31.34 O ATOM 648 N PHE D 405 23.760 −19.693 −3.304 1.00 29.65 N ATOM 649 CA PHE D 405 23.622 −19.876 −1.879 1.00 30.63 C ATOM 650 CB PHE D 405 23.218 −18.562 −1.232 1.00 31.42 C ATOM 651 CG PHE D 405 24.288 −17.527 −1.286 1.00 31.75 C ATOM 652 CD1 PHE D 405 25.274 −17.487 −0.307 1.00 35.92 C ATOM 653 CE1 PHE D 405 26.311 −16.539 −0.370 1.00 32.85 C ATOM 654 CZ PHE D 405 26.370 −15.663 −1.445 1.00 33.62 C ATOM 655 CE2 PHE D 405 25.400 −15.706 −2.437 1.00 32.72 C ATOM 656 CD2 PHE D 405 24.365 −16.641 −2.358 1.00 32.11 C ATOM 657 C PHE D 405 22.566 −20.932 −1.590 1.00 33.31 C ATOM 658 O PHE D 405 21.451 −20.855 −2.111 1.00 36.54 O ATOM 659 N THR D 406 22.926 −21.902 −0.760 1.00 33.36 N ATOM 660 CA THR D 406 22.062 −23.021 −0.436 1.00 38.06 C ATOM 661 CB THR D 406 22.601 −24.342 −1.053 1.00 38.53 C ATOM 662 OG1 THR D 406 23.974 −24.507 −0.704 1.00 35.56 O ATOM 663 CG2 THR D 406 22.501 −24.312 −2.588 1.00 37.55 C ATOM 664 C THR D 406 21.935 −23.134 1.091 1.00 40.79 C ATOM 665 O THR D 406 22.954 −23.092 1.812 1.00 37.09 O ATOM 666 N ALA D 407 20.691 −23.263 1.585 1.00 40.64 N ATOM 667 CA ALA D 407 20.417 −23.362 3.038 1.00 41.09 C ATOM 668 CB ALA D 407 18.912 −23.505 3.283 1.00 45.14 C ATOM 669 C ALA D 407 21.180 −24.530 3.653 1.00 37.86 C ATOM 670 O ALA D 407 21.373 −25.540 2.995 1.00 43.09 O ATOM 671 N THR D 408 21.657 −24.385 4.888 1.00 40.60 N ATOM 672 CA THR D 408 22.302 −25.517 5.596 1.00 42.26 C ATOM 673 CB THR D 408 23.536 −25.097 6.437 1.00 44.72 C ATOM 674 OG1 THR D 408 23.170 −24.066 7.366 1.00 46.70 O ATOM 675 CG2 THR D 408 24.660 −24.580 5.539 1.00 40.92 C ATOM 676 C THR D 408 21.309 −26.316 6.462 1.00 46.74 C ATOM 677 O THR D 408 21.604 −27.452 6.836 1.00 49.03 O ATOM 678 N LYS D 409 20.136 −25.726 6.746 1.00 47.36 N ATOM 679 CA LYS D 409 19.074 −26.346 7.577 1.00 48.62 C ATOM 680 CB LYS D 409 18.809 −25.522 8.824 1.00 45.69 C ATOM 681 CG LYS D 409 19.944 −25.541 9.835 1.00 51.26 C ATOM 682 CD LYS D 409 19.983 −24.258 10.648 1.00 53.2.4 C ATOM 683 CE LYS D 409 18.628 −23.967 11.290 1.00 61.47 C ATOM 684 NZ LYS D 409 18.340 −22.508 11.425 1.00 63.72 N ATOM 685 C LYS D 409 17.764 −26.517 6.795 1.00 51.47 C ATOM 686 O LYS D 409 17.393 −25.659 5.970 1.00 49.06 O ATOM 687 N LYS D 410 17.060 −27.615 7.065 1.00 53.93 N ATOM 688 CA LYS D 410 15.940 −28.027 6.209 1.00 58.44 C ATOM 689 CB LYS D 410 15.453 −29.488 6.497 1.00 64.54 C ATOM 690 CG LYS D 410 15.784 −30.075 7.887 1.00 65.93 C ATOM 691 CD LYS D 410 16.639 −31.354 7.834 1.00 65.85 C ATOM 692 CE LYS D 410 18.146 −31.054 8.138 1.00 65.05 C ATOM 693 NZ LYS D 410 18.359 −30.001 9.191 1.00 60.95 N ATOM 694 C LYS D 410 14.785 −27.011 6.212 1.00 56.91 C ATOM 695 O LYS D 410 13.947 −27.013 5.313 1.00 57.57 O ATOM 696 N ASP D 411 14.783 −26.111 7.186 1.00 59.08 N ATOM 697 CA ASP D 411 13.618 −25.258 7.430 1.00 65.72 C ATOM 698 CB ASP D 411 13.082 −25.535 8.833 1.00 73.37 C ATOM 699 CG ASP D 411 14.147 −25.367 9.897 1.00 81.80 C ATOM 700 OD1 ASP D 411 15.291 −25.851 9.685 1.00 88.21 O ATOM 701 OD2 ASP D 411 13.846 −24.740 10.937 1.00 80.86 O ATOM 702 C ASP D 411 13.850 −23.743 7.248 1.00 64.74 C ATOM 703 O ASP D 411 13.125 −22.921 7.827 1.00 63.98 O ATOM 704 N MET D 412 14.845 −23.374 6.449 1.00 55.03 N ATOM 705 CA MET D 412 15.019 −21.981 6.059 1.00 52.58 C ATOM 706 CB MET D 412 16.493 −21.687 5.786 1.00 47.34 C ATOM 707 CG MET D 412 17.346 −21.684 7.039 1.00 53.29 C ATOM 708 SD MET D 412 19.096 −21.889 6.646 1.00 53.58 S ATOM 709 CE MET D 412 19.824 −22.015 8.279 1.00 54.84 C ATOM 710 C MET D 412 14.212 −21.743 4.807 1.00 46.92 C ATOM 711 O MET D 412 14.058 −22.640 3.996 1.00 48.77 0 ATOM 712 N SER D 413 13.685 −20.544 4.644 1.00 48.92 N ATOM 713 CA SER D 413 13.066 −20.189 3.369 1.00 53.36 C ATOM 714 CB SER D 413 11.565 −19.872 3.502 1.00 52.93 C ATOM 715 OG SER D 413 11.341 −18.485 3.667 1.00 60.47 0 ATOM 716 C SER D 413 13.900 −19.048 2.788 1.00 56.70 C ATOM 717 O SER D 413 14.492 −18.287 3.556 1.00 60.21 0 ATOM 718 N PRO D 414 13.797 −18.821 1.459 1.00 56.00 N ATOM 719 CA PRO D 414 14.803 −19.185 0.495 1.00 49.97 C ATOM 720 CB PRO D 414 15.658 −17.905 0.397 1.00 52.55 C ATOM 721 CG PRO D 414 14.699 −16.793 0.729 1.00 52.15 C ATOM 722 CD PRO D 414 13.390 −17.432 1.186 1.00 58.26 C ATOM 723 C PRO D 414 15.585 −20.440 0.924 1.00 47.31 C ATOM 724 O PRO D 414 16.342 −20.389 1.886 1.00 53.96 0 ATOM 725 N GLN D 415 15.336 −21.575 0.267 1.00 44.49 N ATOM 726 CA GLN D 415 16.218 −22.720 0.396 1.00 44.36 C ATOM 727 CB GLN D 415 15.508 −24.040 0.075 1.00 46.40 C ATOM 728 CG GLN D 415 14.827 −24.681 1.295 1.00 50.25 C ATOM 729 CD GLN D 415 15.794 −25.347 2.298 1.00 49.90 C ATOM 730 OE1 GLN D 415 15.825 −24.993 3.493 1.00 45.63 0 ATOM 731 NE2 GLN D 415 16.560 −26.341 1.822 1.00 47.81 N ATOM 732 C GLN D 415 17.435 −22.527 −0.501 1.00 43.40 C ATOM 733 O GLN D 415 18.494 −23.077 −0.246 1.00 43.07 0 ATOM 734 N LYS D 416 17.268 −21.758 −1.566 1.00 45.58 N ATOM 735 CA LYS D 416 18.397 −21.281 −2.356 1.00 45.59 C ATOM 736 CB LYS D 416 18.837 −22.293 −3.436 1.00 49.29 C ATOM 737 CG LYS D 416 17.801 −22.692 −4.471 1.00 52.09 C ATOM 738 CD LYS D 416 17.878 −24.199 −4.679 1.00 61.35 C ATOM 739 CE LYS D 416 17.847 −24.606 −6.150 1.00 68.77 C ATOM 740 NZ LYS D 416 16.579 −24.219 −6.834 1.00 73.29 N ATOM 741 C LYS D 416 18.074 −19.938 −2.963 1.00 44.98 C ATOM 742 O LYS D 416 16.912 −19.546 −3.040 1.00 40.71 0 ATOM 743 N PHE D 417 19.127 −19.233 −3.352 1.00 40.53 N ATOM 744 CA PHE D 417 19.041 −17.970 −4.067 1.00 38.14 C ATOM 745 CB PHE D 417 18.583 −16.823 −3.146 1.00 36.09 C ATOM 746 CG PHE D 417 19.581 −16.433 −2.078 1.00 34.05 C ATOM 747 CD1 PHE D 417 20.497 −15.407 −2.296 1.00 32.39 C ATOM 748 CE1 PHE D 417 21.386 −15.040 −1.312 1.00 29.72 C ATOM 749 CZ PHE D 417 21.354 −15.673 −0.085 1.00 30.91 C ATOM 750 CE2 PHE D 417 20.441 −16.688 0.154 1.00 32.01 C ATOM 751 CD2 PHE D 417 19.552 −17.045 −0.831 1.00 32.25 C ATOM 752 C PHE D 417 20.426 −17.676 −4.634 1.00 36.13 C ATOM 753 O PHE D 417 21.382 −18.394 −4.322 1.00 38.34 O ATOM 754 N TRP D 418 20.547 −16.623 −5.449 1.00 34.85 N ATOM 755 CA TRP D 418 21.834 −16.301 −6.086 1.00 34.57 C ATOM 756 CB TRP D 418 21.774 −16.533 −7.590 1.00 35.19 C ATOM 757 CG TRP D 418 21.245 −17.888 −8.005 1.00 42.13 C ATOM 758 CD1 TRP D 418 19.926 −18.363 −7.906 1.00 44.36 C ATOM 759 NE1 TRP D 418 19.826 −19.627 −8.414 1.00 48.62 N ATOM 760 CE2 TRP D 418 21.034 −20.45 −8.876 1.00 46.98 C ATOM 761 CD2 TRP D 418 21.990 −18.960 −8.643 1.00 44.41 C ATOM 762 CE3 TRP D 418 23.307 −19.126 −9.036 1.00 47.59 C ATOM 763 CZ3 TRP D 418 23.679 −20.342 −9.637 1.00 50.85 C ATOM 764 CH2 TRP D 418 22.753 −21.369 −9.850 1.00 48.68 C ATOM 765 CZ2 TRP D 418 21.410 −21.240 −9.465 1.00 49.90 C ATOM 766 C TRP D 418 22.271 −14.900 −5.817 1.00 35.46 C ATOM 767 O TRP D 418 21.443 −13.975 −5.710 1.00 30.00 O ATOM 768 N GLY D 419 23.582 −14.734 −5.683 1.00 33.82 N ATOM 769 CA GLY D 419 24.192 −13.419 −5.663 1.00 33.01 C ATOM 770 C GLY D 419 24.971 −13.284 −6.963 1.00 36.02 C ATOM 771 O GLY D 419 25.888 −14.092 −7.241 1.00 35.80 O ATOM 772 N LEU D 420 24.592 −12.290 −7.765 1.00 36.03 N ATOM 773 CA LEU D 420 25.197 −12.041 −9.054 1.00 34.91 C ATOM 774 CB LEU D 420 24.132 −11.980 −10.127 1.00 35.27 C ATOM 775 CG LEU D 420 23.136 −13.140 −10.175 1.00 38.07 C ATOM 776 CD1 LEU D 420 22.183 −12.964 −11.347 1.00 38.18 C ATOM 777 CD2 LEU D 420 23.871 −14.465 −10.279 1.00 39.20 C ATOM 778 C LEU D 420 25.973 −10.741 −9.037 1.00 34.88 C ATOM 779 O LEU D 420 25.449 −9.728 −8.633 1.00 33.14 O ATOM 780 N THR D 421 27.223 −10.789 −9.500 1.00 33.61 N ATOM 781 CA THR D 421 28.070 −9.614 −9.646 1.00 33.48 C ATOM 782 CB THR D 421 29.501 −10.031 −10.021 1.00 35.48 C ATOM 783 OG1 THR D 421 30.020 −10.861 −8.988 1.00 35.63 O ATOM 784 CG2 THR D 421 30.429 −8.792 −10.220 1.00 31.94 C ATOM 785 C THR D 421 27.541 −8.673 −10.745 1.00 34.91 C ATOM 786 O THR D 421 27.532 −9.028 −11.912 1.00 32.45 O ATOM 787 N ARG D 422 27.150 −7.462 −10.356 1.00 32.57 N ATOM 788 CA ARG D 422 26.544 −6.500 −11.265 1.00 35.67 C ATOM 789 CB ARG D 422 26.186 −5.188 −10.545 1.00 32.53 C ATOM 790 CG ARG D 422 24.976 −5.395 −9.664 1.00 34.37 C ATOM 791 CD ARG D 422 24.599 −4.133 −8.920 1.00 39.73 C ATOM 792 NE ARG D 422 23.741 −3.255 −9.707 1.00 41.31 N ATOM 793 CZ ARG D 422 23.105 −2.214 −9.186 1.00 45.47 C ATOM 794 NH1 ARG D 422 22.344 −1.437 −9.941 1.00 52.28 N ATOM 795 NH2 ARG D 422 23.231 −1.955 −7.894 1.00 44.48 N ATOM 796 C ARG D 422 27.377 −6.217 −12.480 1.00 37.00 C ATOM 797 O ARG D 422 26.841 −6.177 −13.599 1.00 35.54 O ATOM 798 N SER D 423 28.673 −6.010 −12.276 1.00 35.16 N ATOM 799 CA SER D 423 29.548 −5.649 −13.384 1.00 37.50 C ATOM 800 CB SER D 423 30.908 −5.159 −12.869 1.00 37.61 C ATOM 801 OG SER D 423 31.581 −6.218 −12.213 1.00 40.96 O ATOM 802 C SER D 423 29.743 −6.811 −14.366 1.00 36.57 C ATOM 803 O SER D 423 30.273 −6.603 −15.457 1.00 37.90 O ATOM 804 N ALA D 424 29.285 −8.010 −13.992 1.00 35.52 N ATOM 805 CA ALA D 424 29.423 −9.214 −14.839 1.00 39.23 C ATOM 806 CB ALA D 424 29.606 −10.459 −13.971 1.00 34.36 C ATOM 807 C ALA D 424 28.236 −9.415 −15.785 1.00 40.37 C ATOM 808 O ALA D 424 28.254 −10.297 −16.646 1.00 40.75 O ATOM 809 N LEU D 425 27.203 −8.605 −15.608 1.00 40.47 N ATOM 810 CA LEU D 425 25.929 −8.783 −16.310 1.00 42.94 C ATOM 811 CB LEU D 425 24.818 −8.943 −15.278 1.00 40.50 C ATOM 812 CG LEU D 425 24.869 −10.120 −14.338 1.00 37.11 C ATOM 813 CD1 LEU D 425 23.696 −10.009 −13.385 1.00 41.00 C ATOM 814 CD2 LEU D 425 24.796 −11.419 −15.117 1.00 40.09 C ATOM 815 C LEU D 425 25.603 −7.574 −17.187 1.00 45.36 C ATOM 816 O LEU D 425 25.896 −6.444 −16.799 1.00 48.02 O ATOM 817 N LEU D 426 24.983 −7.797 −18.353 1.00 48.44 N ATOM 818 CA LEU D 426 24.461 −6.669 −19.159 1.00 49.08 C ATOM 819 CB LEU D 426 24.909 −6.721 −20.623 1.00 47.43 C ATOM 820 CG LEU D 426 26.233 −5.972 −20.861 1.00 47.17 C ATOM 821 CD1 LEU D 426 26.625 −5.950 −22.337 1.00 43.13 C ATOM 822 CD2 LEU D 426 26.189 −4.555 −20.304 1.00 45.78 C ATOM 823 C LEU D 426 22.956 −6.470 −18.997 1.00 55.73 C ATOM 824 O LEU D 426 22.272 −7.377 −18.544 1.00 60.24 O ATOM 825 N PRO D 427 22.420 −5.365 −19.550 1.00 59.65 N ATOM 826 CA PRO D 427 21.879 −4.240 −18.826 1.00 54.11 C ATOM 827 CB PRO D 427 20.416 −4.640 −18.617 1.00 58.08 C ATOM 828 CG PRO D 427 20.119 −5.550 −19.797 1.00 59.27 C ATOM 829 CD PRO D 427 21.423 −5.779 −20.550 1.00 61.29 C ATOM 830 C PRO D 427 22.635 −3.929 −17.524 1.00 54.24 C ATOM 831 O PRO D 427 22.547 −4.670 −16.543 1.00 49.51 O ATOM 832 N THR D 428 23.438 −2.866 −17.559 1.00 56.51 N ATOM 833 CA THR D 428 23.823 −2.148 −16.345 1.00 59.23 C ATOM 834 CB THR D 428 24.746 −0.977 −16.688 1.00 60.62 C ATOM 835 OG1 THR D 428 26.050 −1.479 −16.979 1.00 57.71 O ATOM 836 CG2 THR D 428 24.809 0.056 −15.529 1.00 56.02 C ATOM 837 C THR D 428 22.569 −1.555 −15.695 1.00 61.51 C ATOM 838 O THR D 428 21.866 −0.773 −16.330 1.00 64.20 O ATOM 839 N ILE D 429 22.293 −1.925 −14.446 1.00 60.26 N ATOM 840 CA ILE D 429 21.167 −1.351 −13.698 1.00 60.74 C ATOM 841 CB ILE D 429 20.656 −2.333 −12.611 1.00 58.14 C ATOM 842 CG1 ILE D 429 19.943 −3.507 −13.301 1.00 56.28 C ATOM 843 CD1 ILE D 429 19.804 −4.765 −12.474 1.00 49.01 C ATOM 844 CG2 ILE D 429 19.715 −1.634 −11.630 1.00 57.91 C ATOM 845 C ILE D 429 21.527 0.051 −13.147 1.00 66.55 C ATOM 846 O ILE D 429 22.592 0.224 −12.553 1.00 64.35 O ATOM 847 N PRO D 430 20.655 1.067 −13.385 1.00 69.25 N ATOM 848 CA PRO D 430 20.988 2.438 −12.986 1.00 71.23 C ATOM 849 CB PRO D 430 20.248 3.294 −14.025 1.00 69.05 C ATOM 850 CG PRO D 430 19.161 2.414 −14.583 1.00 69.00 C ATOM 851 CD PRO D 430 19.339 1.012 −14.051 1.00 68.13 C ATOM 852 C PRO D 430 20.489 2.769 −11.586 1.00 74.22 C ATOM 853 O PRO D 430 21.271 2.765 −10.639 1.00 79.89 0 ATOM 854 ZN ZN A 1 29.497 −15.700 −20.832 1.00 47.26 ZN ATOM 855 ZN ZN A 2 24.275 0.066 −0.106 1.00 42.90 ZN ATOM 856 ZN ZN A 3 36.150 −15.869 −6.982 1.00 41.44 ZN ATOM 857 C20 MOL E 1 35.312 −25.069 −2.357 1.00 69.98 C ATOM 858 C21 MOL E 1 34.783 −26.389 −1.776 1.00 73.54 C ATOM 859 O5 MOL E 1 34.913 −27.449 −2.740 1.00 67.11 O ATOM 860 C22 MOL E 1 36.311 −27.662 −2.954 1.00 72.97 C ATOM 861 C23 MOL E 1 36.924 −26.420 −3.618 1.00 70.46 C ATOM 862 N3 MOL E 1 36.713 −25.195 −2.812 1.00 67.80 N ATOM 863 C19 MOL E 1 36.946 −24.107 −3.762 1.00 57.15 C ATOM 864 C18 MOL E 1 37.379 −22.768 −3.139 1.00 50.27 C ATOM 865 C24 MOL E 1 38.406 −22.665 −2.199 1.00 43.80 C ATOM 866 C25 MOL E 1 38.773 −21.408 −1.702 1.00 43.53 C ATOM 867 C17 MOL E 1 36.744 −21.619 −3.592 1.00 46.35 C ATOM 868 C16 MOL E 1 37.108 −20.374 −3.101 1.00 45.03 C ATOM 869 C15 MOL E 1 38.126 −20.260 −2.163 1.00 39.75 C ATOM 870 C14 MOL E 1 38.438 −18.981 −1.709 1.00 38.24 C ATOM 871 O4 MOL E 1 37.335 −18.072 −1.694 1.00 40.16 O ATOM 872 C3 MOL E 1 37.533 −16.727 −1.732 1.00 38.85 C ATOM 873 C2 MOL E 1 38.780 −16.122 −1.874 1.00 39.41 C ATOM 874 Cl MOL E 1 38.862 −14.727 −1.898 1.00 34.38 C ATOM 875 C7 MOL E 1 37.709 −13.937 −1.777 1.00 39.90 C ATOM 876 C6 MOL E 1 36.460 −14.550 −1.652 1.00 39.47 C ATOM 877 C8 MOL E 1 35.150 −14.077 −1.475 1.00 41.09 C ATOM 878 O1 MOL E 1 34.839 −12.888 −1.348 1.00 39.84 O ATOM 879 C4 MOL E 1 36.407 −15.934 −1.618 1.00 38.12 C ATOM 880 C5 MOL E 1 34.969 −16.373 −1.448 1.00 38.27 C ATOM 881 N1 MOL E 1 34.288 −15.085 −1.307 1.00 40.64 N ATOM 882 C9 MOL E 1 32.864 −14.914 −0.964 1.00 38.72 C ATOM 883 C13 MOL E 1 31.932 −15.946 −1.616 1.00 36.16 C ATOM 884 C12 MOL E 1 30.485 −15.586 −1.237 1.00 36.41 C ATOM 885 C11 MOL E 1 30.336 −15.577 0.299 1.00 39.73 C ATOM 886 O2 MOL E 1 29.256 −15.858 0.824 1.00 42.02 O ATOM 887 N2 MOL E 1 31.447 −15.316 1.116 1.00 35.12 N ATOM 888 C10 MOL E 1 32.695 −14.981 0.560 1.00 40.61 C ATOM 889 O3 MOL E 1 33.643 −14.726 1.309 1.00 35.82 O ATOM 890 O HOH C 1 32.948 −22.507 −16.031 1.00 66.61 O ATOM 891 O HOH C 2 30.369 −11.514 −17.508 1.00 36.77 O ATOM 892 O HOH C 3 24.026 −5.425 −14.082 1.00 47.87 O ATOM 893 O HOH C 4 31.867 −3.597 −1.435 1.00 41.94 O ATOM 894 O HOH C 5 32.172 −23.320 −2.350 1.00 40.01 O ATOM 895 O HOH C 6 29.775 −5.487 −9.681 1.00 44.79 O ATOM 896 O HOH C 7 32.901 −22.606 −4.847 1.00 34.25 O ATOM 897 O HOH C 8 34.512 −16.875 −10.391 1.00 38.11 O ATOM 898 O HOH C 9 35.680 −11.173 −11.710 1.00 44.70 O ATOM 899 O HOH C 10 37.220 −13.035 −12.607 1.00 58.31 O ATOM 900 O HOH C 11 33.259 −14.936 8.906 1.00 68.37 O ATOM 901 O HOH C 12 33.552 −18.239 8.752 1.00 52.97 O ATOM 902 O HOH C 13 33.576 −12.668 3.223 1.00 43.35 O END

TABLE 8 Atomic coordinates for unbound CRBN-CRBN (TBD) (Apo) (Murine protein) HEADER XX-XXX-9-   xxxx COMPND REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.6.0117 REMARK 3 AUTHORS : MURSHUDOV, VAGIN, DODSON REMARK 3 REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.30 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 REMARK 3 DATA CUTOFF (SIGMA(F)) : NONE REMARK 3 COMPLETENESS FOR RANGE (%) : 99.87 REMARK 3 NUMBER OF REFLECTIONS : 12075 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSSVALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VAL UE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.22851 REMARK 3 R VALUE (WORKING SET) : 0.22458 REMARK 3 FREE R VALUE : 0.30679 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.9 REMARK 3 FREE R VALUE TEST SET COUNT : 620 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH : 2.300 REMARK 3 BIN RESOLUTION RANGE LOW : 2.360 REMARK 3 REFLECTION IN BIN (WORKING SET) : 803 REMARK 3 BIN COMPLETENESS (WORKING + TEST) (%) : 99.88 REMARK 3 BIN R VALUE (WORKING SET) : 0.259 REMARK 3 BIN FREE R VALUE SET COUNT 38 REMARK 3 BIN FREE R VALUE : 0.368 REMARK 3 REMARK 3 NUMBER OF NONHYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 ALL ATOMS : 1610 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 52.954 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : NULL REMARK 3 B22 (A**2) : NULL REMARK 3 B33 (A**2) : NULL REMARK 3 B12 (A**2) : NULL REMARK 3 B13 (A**2) : NULL REMARK 3 B23 (A**2) : NULL REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A ): 0.281 REMARK 3 ESU BASED ON FREE R VAL UE (A) : 0.262 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A) : 0.203 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD(A**2) : 8.210 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FOFC : 0.943 REMARK 3 CORRELATION COEFFICIENT FOFC FREE : 0.913 REMARK 3 REMARK 3 RMS DEVIATIONS FROMIDEAL VALUES   COUNT   RMS   WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A):     1642 ;   0.015 ;   0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES):  2234 ;   1.899 ;   1.954 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES):    198 ;   8.790 ;   5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES):   56 ;43.   316 ;  23.750 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES):   273 ;   18.925 ;  15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES):   4 ;    17.860 ;  15.000 REMARK 3 CHIRALCENTER RESTRAINTS (A**3):     256 ;    0.122;    0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A):   1170 ;     0.014 ;   0.021 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NCS TYPE: LOCAL REMARK 3 NUMBER OF DIFFERENT NCS PAIRS : 1 REMARK 3 GROUP  CHAIN1  RANGE  CHAIN2   RANGE  COUNT  RMS  WEIGHT REMARK 3   1   D  322   427    A   322   427   118   0.19   0.05 REMARK 3 REMARK 3 TWIN DETAILS REMARK 3 NUMBER OF TWIN DOMAINS : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED: MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT REMARK 3 U VALUES : REFINED INDIVIDUALLY REMARK 3 CISPEP 1 SER D   413   PRO D   414 0.00 CISPEP 2 SER A   413   PRO A   414 0.00 SSBOND 1 CYS A   329   CYS A   326 LINKR       PRO D   355   GLU D   361   gap LINKR       ALA A   351   TYR A   358   gap LINKR       SER D   344   GLU D   361   gap LINKR       SER A   344   GLU A   361   gap CRYST1 119.260   119.260   119.260   90.00   90.00   90.00 I 21 3 SCALE1   0.008385   0.000000   0.000000   0.00000 SCALE2   0.000000   0.008385   0.000000   0.00000 SCALE3   0.000000   0.000000   0.008385   0.00000 ATOM 1 N THR D 322 3.272 14.657 13.569 1.00 64.62 N ATOM 2 CA THR D 322 3.270 14.354 12.096 1.00 56.77 C ATOM 3 CB THR D 322 4.075 13.067 11.736 1.00 59.13 C ATOM 4 OG1 THR D 322 3.399 11.904 12.224 1.00 62.54 O ATOM 5 CG2 THR D 322 5.549 13.085 12.213 1.00 69.21 C ATOM 6 C THR D 322 1.878 14.263 11.376 1.00 53.27 C ATOM 7 O THR D 322 1.814 14.024 10.159 1.00 46.87 O ATOM 8 N SER D 323 0.777 14.411 12.102 1.00 49.61 N ATOM 9 CA SER D 323 −0.552 14.200 11.499 1.00 48.06 C ATOM 10 CB SER D 323 −1.613 14.020 12.582 1.00 47.31 C ATOM 11 OG SER D 323 −1.239 12.953 13.380 1.00 50.21 O ATOM 12 C SER D 323 −1.008 15.334 10.653 1.00 48.09 C ATOM 13 O SER D 323 −0.835 16.497 11.019 1.00 54.45 O ATOM 14 N LEU D 324 −1.641 14.999 9.537 1.00 46.35 N ATOM 15 CA LEU D 324 −2.317 16.012 8.747 1.00 46.17 C ATOM 16 CB LEU D 324 −1.777 16.028 7.326 1.00 44.87 C ATOM 17 CG LEU D 324 −0.272 16.315 7.262 1.00 52.31 C ATOM 18 CD1 LEU D 324 −0.296 15.937 5.905 1.00 46.65 C ATOM 19 CD2 LEU D 324 −0.068 17.770 7.615 1.00 50.32 C ATOM 20 C LEU D 324 −3.825 15.725 8.795 1.00 49.15 C ATOM 21 O LEU D 324 −4.305 14.664 8.342 1.00 47.14 O ATOM 22 N CYS D 325 −4.548 16.675 9.383 1.00 43.84 N ATOM 23 CA CYS D 325 −5.932 16.496 9.817 1.00 44.84 C ATOM 24 CB CYS D 325 −6.077 16.857 11.309 1.00 42.45 C ATOM 25 SG CYS D 325 −5.337 15.652 12.480 1.00 58.67 S ATOM 26 C CYS D 325 −6.837 17.393 8.971 1.00 45.43 C ATOM 27 O CYS D 325 −6.404 18.460 8.525 1.00 40.81 O ATOM 28 N CYS D 326 −8.073 16.955 8.745 1.00 45.40 N ATOM 29 CA CYS D 326 −9.097 17.797 8.109 1.00 47.57 C ATOM 30 CB CYS D 326 −10.438 17.038 8.128 1.00 42.62 C ATOM 31 SG CYS D 326 −11.946 17.943 7.666 1.00 46.51 S ATOM 32 C CYS D 326 −9.225 19.113 8.897 1.00 50.01 C ATOM 33 O CYS D 326 −9.475 19.062 10.111 1.00 49.04 O ATOM 34 N LYS D 327 −9.020 20.252 8.213 1.00 47.57 N ATOM 35 CA LYS D 327 −9.212 21.628 8.751 1.00 55.56 C ATOM 36 CB LYS D 327 −8.862 22.705 7.689 1.00 55.05 C ATOM 37 CG LYS D 327 −8.733 24.143 8.220 1.00 64.17 C ATOM 38 CD LYS D 327 −8.407 25.203 7.146 1.00 67.49 C ATOM 39 CE LYS D 327 −9.487 25.335 6.061 1.00 76.07 C ATOM 40 NZ LYS D 327 −9.698 26.728 5.544 1.00 78.00 N ATOM 41 C LYS D 327 −10.614 21.901 9.328 1.00 52.50 C ATOM 42 O LYS D 327 −10.728 22.565 10.359 1.00 55.95 O ATOM 43 N GLN D 328 −11.659 21.387 8.678 1.00 50.49 N ATOM 44 CA GLN D 328 −13.044 21.577 9.143 1.00 51.61 C ATOM 45 CB GLN D 328 −14.044 21.073 8.103 1.00 56.84 C ATOM 46 CG GLN D 328 −15.532 21.278 8.463 1.00 54.76 C ATOM 47 CD GLN D 328 −15.879 22.743 8.801 1.00 61.69 C ATOM 48 OE1 GLN D 328 −15.462 23.677 8.112 1.00 57.77 O ATOM 49 NE2 GLN D 328 −16.643 22.937 9.885 1.00 54.96 N ATOM 50 C GLN D 328 −13.364 20.966 10.523 1.00 52.52 C ATOM 51 O GLN D 328 −13.807 21.664 11.429 1.00 51.02 O ATOM 52 N CYS D 329 −13.140 19.666 10.693 1.00 51.16 N ATOM 53 CA CYS D 329 −13.587 18.987 11.901 1.00 44.18 C ATOM 54 CB CYS D 329 −14.281 17.682 11.497 1.00 47.66 C ATOM 55 SG CYS D 329 −13.146 16.391 10.863 1.00 48.39 S ATOM 56 C CYS D 329 −12.432 18.710 12.878 1.00 45.42 C ATOM 57 O CYS D 329 −12.658 18.281 14.001 1.00 58.56 O ATOM 58 N GLN D 330 −11.204 18.864 12.399 1.00 47.51 N ATOM 59 CA GLN D 330 −9.956 18.803 13.195 1.00 55.76 C ATOM 60 CB GLN D 330 −9.780 20.049 14.095 1.00 62.32 C ATOM 61 CG GLN D 330 −9.205 21.205 13.280 1.00 67.86 C ATOM 62 CD GLN D 330 −9.431 22.609 13.850 1.00 74.43 C ATOM 63 OE1 GLN D 330 −9.254 22.847 15.058 1.00 74.35 O ATOM 64 NE2 GLN D 330 −9.783 23.568 12.954 1.00 59.71 N ATOM 65 C GLN D 330 −9.548 17.498 13.872 1.00 52.39 C ATOM 66 O GLN D 330 −8.399 17.127 13.784 1.00 58.40 O ATOM 67 N GLU D 331 −10.470 16.814 14.535 1.00 55.50 N ATOM 68 CA GLU D 331 −10.276 15.436 15.021 1.00 62.68 C ATOM 69 CB GLU D 331 −11.655 14.822 15.216 1.00 67.97 C ATOM 70 CG GLU D 331 −12.291 15.037 16.545 1.00 81.75 C ATOM 71 CD GLU D 331 −13.408 14.064 16.755 1.00 75.98 C ATOM 72 OE1 GLU D 331 −14.019 14.134 17.841 1.00 80.04 O ATOM 73 OE2 GLU D 331 −13.648 13.228 15.849 1.00 68.70 O ATOM 74 C GLU D 331 −9.661 14.451 14.020 1.00 55.88 C ATOM 75 O GLU D 331 −8.964 13.516 14.370 1.00 48.88 O ATOM 76 N THR D 332 −10.060 14.585 12.777 1.00 49.03 N ATOM 77 CA THR D 332 −9.875 13.475 11.862 1.00 48.41 C ATOM 78 CB THR D 332 −11.034 13.358 10.870 1.00 42.25 C ATOM 79 OG1 THR D 332 −12.289 13.595 11.562 1.00 41.02 O ATOM 80 CG2 THR D 332 −11.031 11.971 10.349 1.00 42.26 C ATOM 81 C THR D 332 −8.559 13.549 11.109 1.00 44.70 C ATOM 82 O THR D 332 −8.333 14.480 10.320 1.00 47.53 O ATOM 83 N GLU D 333 −7.714 12.539 11.331 1.00 47.04 N ATOM 84 CA GLU D 333 −6.434 12.454 10.605 1.00 49.38 C ATOM 85 CB GLU D 333 −5.421 11.595 11.367 1.00 41.74 C ATOM 86 CG GLU D 333 −4.051 11.576 10.707 1.00 41.19 C ATOM 87 CD GLU D 333 −3.153 10.525 11.310 1.00 41.58 C ATOM 88 OE1 GLU D 333 −2.560 10.821 12.360 1.00 39.87 O ATOM 89 OE2 GLU D 333 −3.052 9.398 10.746 1.00 40.49 O ATOM 90 C GLU D 333 −6.659 11.933 9.203 1.00 40.60 C ATOM 91 O GLU D 333 −7.309 10.913 9.003 1.00 44.41 O ATOM 92 N ILE D 334 −6.145 12.648 8.221 1.00 39.13 N ATOM 93 CA ILE D 334 −6.305 12.230 6.832 1.00 40.13 C ATOM 94 CB ILE D 334 −6.720 13.432 5.933 1.00 45.63 C ATOM 95 CG1 ILE D 334 −8.014 14.067 6.481 1.00 44.93 C ATOM 96 CD1 ILE D 334 −9.218 13.139 6.374 1.00 40.94 C ATOM 97 CG2 ILE D 334 −6.996 12.987 4.493 1.00 42.26 C ATOM 98 C ILE D 334 −5.044 11.496 6.295 1.00 40.76 C ATOM 99 O ILE D 334 −5.145 10.589 5.489 1.00 41.96 O ATOM 100 N THR D 335 −3.865 11.918 6.731 1.00 41.54 N ATOM 101 CA THR D 335 −2.600 11.324 6.320 1.00 39.19 C ATOM 102 CB THR D 335 −2.206 11.633 4.850 1.00 41.57 C ATOM 103 OG1 THR D 335 −1.105 10.796 4.440 1.00 37.99 O ATOM 104 CG2 THR D 335 −1.809 13.099 4.663 1.00 45.26 C ATOM 105 C THR D 335 −1.534 11.778 7.312 1.00 43.17 C ATOM 106 O THR D 335 −1.810 12.524 8.299 1.00 44.12 O ATOM 107 N THR D 336 −0.314 11.316 7.105 1.00 42.30 N ATOM 108 CA THR D 336 0.775 11.774 7.968 1.00 35.78 C ATOM 109 CB THR D 336 1.281 10.659 8.921 1.00 36.27 C ATOM 110 OG1 THR D 336 2.135 9.755 8.234 1.00 37.81 O ATOM 111 CG2 THR D 336 0.169 9.921 9.657 1.00 35.90 C ATOM 112 C THR D 336 1.882 12.247 7.092 1.00 36.85 C ATOM 113 O THR D 336 1.907 11.962 5.864 1.00 41.31 O ATOM 114 N LYS D 337 2.840 12.931 7.686 1.00 40.98 N ATOM 115 CA LYS D 337 3.978 13.453 6.909 1.00 39.49 C ATOM 116 CB LYS D 337 4.846 14.377 7.789 1.00 44.44 C ATOM 117 CG LYS D 337 4.342 15.837 7.937 1.00 54.47 C ATOM 118 CD LYS D 337 5.148 16.721 8.956 1.00 54.95 C ATOM 119 CE LYS D 337 4.562 16.604 10.380 1.00 62.13 C ATOM 120 NZ LYS D 337 5.006 17.542 11.471 1.00 54.68 N ATOM 121 C LYS D 337 4.831 12.309 6.376 1.00 38.83 C ATOM 122 O LYS D 337 5.518 12.471 5.382 1.00 36.42 O ATOM 123 N ASN D 338 4.802 11.155 7.033 1.00 39.65 N ATOM 124 CA ASN D 338 5.576 9.971 6.599 1.00 37.97 C ATOM 125 CB ASN D 338 5.376 8.861 7.605 1.00 42.07 C ATOM 126 CG ASN D 338 6.010 9.186 8.956 1.00 48.60 C ATOM 127 OD1 ASN D 338 5.328 9.296 9.958 1.00 51.36 O ATOM 128 ND2 ASN D 338 7.311 9.327 8.976 1.00 41.86 N ATOM 129 C ASN D 338 5.165 9.433 5.214 1.00 40.36 C ATOM 130 O ASN D 338 5.935 8.741 4.543 1.00 36.07 O ATOM 131 N GLU D 339 3.939 9.737 4.802 1.00 35.85 N ATOM 132 CA GLU D 339 3.418 9.219 3.527 1.00 35.86 C ATOM 133 CB GLU D 339 1.939 8.920 3.628 1.00 33.23 C ATOM 134 CG GLU D 339 1.613 8.095 4.871 1.00 38.12 C ATOM 135 CD GLU D 339 2.348 6.765 4.843 1.00 41.29 C ATOM 136 OE1 GLU D 339 2.328 6.076 3.766 1.00 36.54 O ATOM 137 OE2 GLU D 339 2.993 6.435 5.864 1.00 42.89 O ATOM 138 C GLU D 339 3.681 10.101 2.308 1.00 35.63 C ATOM 139 O GLU D 339 3.378 9.686 1.212 1.00 39.41 O ATOM 140 N ILE D 340 4.229 11.299 2.519 1.00 38.49 N ATOM 141 CA ILE D 340 4.489 12.247 1.448 1.00 37.67 C ATOM 142 CB ILE D 340 4.963 13.601 2.002 1.00 39.26 C ATOM 143 CG1 ILE D 340 3.784 14.299 2.689 1.00 40.96 C ATOM 144 CD1 ILE D 340 4.163 15.546 3.489 1.00 42.37 C ATOM 145 CG2 ILE D 340 5.452 14.503 0.849 1.00 42.48 C ATOM 146 C ILE D 340 5.549 11.738 0.505 1.00 39.51 C ATOM 147 O ILE D 340 6.581 11.198 0.924 1.00 35.48 O ATOM 148 N PHE D 341 5.290 11.921 −0.787 1.00 41.90 N ATOM 149 CA PHE D 341 6.286 11.635 −1.785 1.00 40.38 C ATOM 150 CB PHE D 341 6.175 10.184 −2.294 1.00 38.00 C ATOM 151 CG PHE D 341 5.026 9.945 −3.207 1.00 36.08 C ATOM 152 CD1 PHE D 341 5.235 9.719 −4.552 1.00 32.92 C ATOM 153 CE1 PHE D 341 4.165 9.524 −5.391 1.00 32.01 C ATOM 154 CZ PHE D 341 2.871 9.484 −4.878 1.00 37.44 C ATOM 155 CE2 PHE D 341 2.648 9.672 −3.541 1.00 33.23 C ATOM 156 CD2 PHE D 341 3.719 9.919 −2.704 1.00 36.33 C ATOM 157 C PHE D 341 6.230 12.645 −2.911 1.00 44.71 C ATOM 158 O PHE D 341 5.365 13.506 −2.927 1.00 42.80 O ATOM 159 N SER D 342 7.139 12.497 −3.877 1.00 46.63 N ATOM 160 CA SER D 342 7.237 13.424 −4.989 1.00 44.33 C ATOM 161 CB SER D 342 8.622 14.091 −4.979 1.00 48.28 C ATOM 162 OG SER D 342 8.759 14.915 −6.117 1.00 52.70 O ATOM 163 C SER D 342 7.011 12.708 −6.301 1.00 43.33 C ATOM 164 O SER D 342 7.859 11.973 −6.759 1.00 42.07 O ATOM 165 N LEU D 343 5.842 12.908 −6.885 1.00 47.09 N ATOM 166 CA LEU D 343 5.453 12.273 −8.133 1.00 46.30 C ATOM 167 CB LEU D 343 3.934 12.213 −8.227 1.00 43.43 C ATOM 168 CG LEU D 343 3.118 11.373 −9.221 1.00 48.56 C ATOM 169 CD1 LEU D 343 2.726 12.187 −10.436 1.00 60.72 C ATOM 170 CD2 LEU D 343 3.761 10.053 −9.627 1.00 46.02 C ATOM 171 C LEU D 343 5.996 13.147 −9.265 1.00 48.21 C ATOM 172 O LEU D 343 5.705 14.346 −9.347 1.00 40.71 O ATOM 173 N SER D 344 6.791 12.548 −10.138 1.00 40.44 N ATOM 174 CA SER D 344 7.365 13.341 −11.194 1.00 50.50 C ATOM 175 CB SER D 344 8.653 12.670 −11.683 1.00 53.39 C ATOM 176 OG SER D 344 8.725 12.771 −13.086 1.00 58.30 O ATOM 177 C SER D 344 6.319 13.528 −12.307 1.00 51.02 C ATOM 178 O SER D 344 5.720 12.547 −12.750 1.00 45.55 O ATOM 179 N LEU D 345 6.084 17.791 −12.708 1.00 54.39 N ATOM 180 CA LEU D 345 5.132 15.159 −13.762 1.00 57.02 C ATOM 181 CB LEU D 345 4.702 16.607 −13.568 1.00 56.01 C ATOM 182 CG LEU D 345 3.586 16.832 −12.526 1.00 68.64 C ATOM 183 CD1 LEU D 345 2.686 15.601 −12.349 1.00 50.71 C ATOM 184 CD2 LEU D 345 4.129 17.319 −11.179 1.00 63.77 C ATOM 185 C LEU D 345 5.633 14.956 −15.199 1.00 59.80 C ATOM 186 O LEU D 345 4.883 14.603 −16.119 1.00 59.84 O ATOM 187 N CYS D 346 6.908 15.196 −15.418 1.00 60.63 N ATOM 188 CA CYS D 346 7.452 15.068 −16.769 1.00 58.10 C ATOM 189 CB CYS D 346 8.806 15.738 −16.763 1.00 59.30 C ATOM 190 SG CYS D 346 9.932 14.849 −15.676 1.00 62.23 S ATOM 191 C CYS D 346 7.536 13.570 −17.152 1.00 56.66 C ATOM 192 O CYS D 346 7.422 12.698 −16.273 1.00 52.17 O ATOM 193 N GLY D 347 7.715 13.259 −18.439 1.00 59.35 N ATOM 194 CA GLY D 347 7.877 11.847 −18.869 1.00 58.45 C ATOM 195 C GLY D 347 9.314 11.454 −19.283 1.00 59.10 O ATOM 196 O GLY D 347 10.289 11.997 −18.749 1.00 52.27 O ATOM 197 N PRO D 348 9.468 10.510 −20.243 1.00 58.55 N ATOM 198 CA PRO D 348 10.842 10.133 −20.666 1.00 52.91 C ATOM 199 CB PRO D 348 10.610 9.237 −21.887 1.00 57.72 C ATOM 200 CG PRO D 348 9.221 8.681 −21.690 1.00 59.26 C ATOM 201 CD PRO D 348 8.434 9.771 −21.004 1.00 57.37 C ATOM 202 C PRO D 348 11.683 11.367 −21.030 1.00 47.28 C ATOM 203 O PRO D 348 11.170 12.312 −21.652 1.00 53.63 O ATOM 204 N MET D 349 12.933 11.348 −20.560 1.00 45.09 N ATOM 205 CA MET D 349 13.940 12.391 −20.717 1.00 51.67 C ATOM 206 CB MET D 349 14.184 12.691 −22.195 1.00 56.76 C ATOM 207 CG MET D 349 15.321 11.882 −22.768 1.00 67.16 C ATOM 208 SD MET D 349 14.804 10.194 −23.122 1.00 82.62 S ATOM 209 CE MET D 349 16.093 9.809 −24.307 1.00 76.12 C ATOM 210 C MET D 349 13.655 13.680 −19.954 1.00 56.01 C ATOM 211 O MET D 349 14.421 14.659 −20.060 1.00 51.99 O ATOM 212 N ALA D 350 12.570 13.672 −19.179 1.00 45.92 N ATOM 213 CA ALA D 350 12.125 14.837 −18.435 1.00 48.64 C ATOM 214 CB ALA D 350 13.080 15.192 −17.305 1.00 43.75 C ATOM 215 C ALA D 350 11.941 15.984 −19.396 1.00 54.11 C ATOM 216 O ALA D 350 12.371 17.111 −19.133 1.00 55.10 O ATOM 217 N ALA D 351 11.304 15.678 −20.527 1.00 55.10 N ATOM 218 CA ALA D 351 10.814 16.715 −21.412 1.00 54.65 C ATOM 219 CB ALA D 351 10.135 16.080 −22.623 1.00 58.21 C ATOM 220 C ALA D 351 9.851 17.672 −20.710 1.00 60.94 C ATOM 221 O ALA D 351 9.202 17.335 −19.704 1.00 63.45 O ATOM 222 N TYR D 352 9.783 18.874 −21.269 1.00 59.73 N ATOM 223 CA TYR D 352 8.778 19.850 −20.962 1.00 61.26 C ATOM 224 CB TYR D 352 8.935 21.000 −21.934 1.00 53.79 C ATOM 225 CG TYR D 352 7.957 22.130 −21.737 1.00 64.11 C ATOM 226 CD1 TYR D 352 8.116 23.025 −20.679 1.00 61.81 C ATOM 227 CE1 TYR D 352 7.244 24.070 −20.485 1.00 56.93 C ATOM 228 CZ TYR D 352 6.170 24.245 −21.347 1.00 62.45 C ATOM 229 OH TYR D 352 5.306 25.291 −21.109 1.00 54.95 O ATOM 230 CE2 TYR D 352 5.976 23.377 −22.410 1.00 66.12 C ATOM 231 CD2 TYR D 352 6.875 22.320 −22.608 1.00 64.41 C ATOM 232 C TYR D 352 7.345 19.298 −21.107 1.00 67.24 C ATOM 233 O TYR D 352 7.085 18.389 −21.930 1.00 56.50 O ATOM 234 N VAL D 353 6.441 19.864 −20.295 1.00 58.64 N ATOM 235 CA VAL D 353 4.986 19.817 −20.536 1.00 72.92 C ATOM 236 CB VAL D 353 4.369 18.431 −20.280 1.00 72.72 C ATOM 237 CG1 VAL D 353 4.159 17.726 −21.611 1.00 67.44 C ATOM 238 CG2 VAL D 353 5.218 17.604 −19.314 1.00 69.43 C ATOM 239 C VAL D 353 4.221 20.909 −19.787 1.00 74.75 C ATOM 240 O VAL D 353 4.808 21.584 −18.927 1.00 75.27 O ATOM 241 N ASN D 354 2.943 21.112 −20.146 1.00 91.62 N ATOM 242 CA ASN D 354 2.011 21.982 −19.378 1.00 95.01 C ATOM 243 CB ASN D 354 2.582 23.392 −19.156 1.00 93.07 C ATOM 244 CG ASN D 354 2.112 24.036 −17.849 1.00 87.99 C ATOM 245 OD1 ASN D 354 2.590 25.109 −17.480 1.00 83.95 O ATOM 246 ND2 ASN D 354 1.190 23.385 −17.141 1.00 91.44 N ATOM 247 C ASN D 354 0.650 22.141 −20.029 1.00 108.66 C ATOM 248 O ASN D 354 0.515 22.94 −20.917 1.00 95.74 O ATOM 256 N GLU D 361 0.649 23.536 −4.858 1.00 73.70 N ATOM 257 CA GLU D 361 −0.666 23.174 −5.386 1.00 78.86 C ATOM 258 CB GLU D 361 −0.494 22.797 −6.882 1.00 94.81 C ATOM 259 CG GLU D 361 −1.725 22.293 −7.657 1.00 101.97 C ATOM 260 CD GLU D 361 −2.660 23.403 −8.126 1.00 103.74 C ATOM 261 OE1 GLU D 361 −3.437 23.920 −7.292 1.00 110.47 O ATOM 262 OE2 GLU D 361 −2.639 23.749 −9.328 1.00 94.85 O ATOM 263 C GLU D 361 −1.306 22.021 −4.557 1.00 81.00 C ATOM 264 O GLU D 361 −2.135 22.230 −3.647 1.00 76.96 O ATOM 265 N THR D 362 −0.883 20.802 −4.865 1.00 67.78 N ATOM 266 CA THR D 362 −1.449 19.598 −4.271 1.00 65.60 C ATOM 267 CB THR D 362 −2.137 18.781 −5.366 1.00 58.43 C ATOM 268 OG1 THR D 362 −3.241 19.541 −5.857 1.00 61.92 O ATOM 269 CG2 THR D 362 −2.654 17.508 −4.836 1.00 62.36 C ATOM 270 C THR D 362 −0.363 18.772 −3.591 1.00 56.83 C ATOM 271 O THR D 362 0.740 18.661 −4.108 1.00 56.12 O ATOM 272 N LEU D 363 −0.669 18.256 −2.411 1.00 47.66 N ATOM 273 CA LEU D 363 0.222 17.332 −1.693 1.00 47.65 C ATOM 274 CB LEU D 363 −0.058 17.445 −0.214 1.00 40.60 C ATOM 275 CG LEU D 363 0.709 16.582 0.759 1.00 47.08 C ATOM 276 CD1 LEU D 363 2.125 17.170 0.863 1.00 47.86 C ATOM 277 CD2 LEU D 363 0.006 16.680 2.113 1.00 47.04 C ATOM 278 C LEU D 363 −0.097 15.883 −2.076 1.00 47.68 C ATOM 279 O LEU D 363 −1.232 15.464 −1.920 1.00 47.43 O ATOM 280 N THR D 364 0.905 15.125 −2.511 1.00 37.30 N ATOM 281 CA THR D 364 0.759 13.717 −2.939 1.00 38.68 C ATOM 282 CB THR D 364 1.527 13.428 −4.270 1.00 39.48 C ATOM 283 OG1 THR D 364 2.922 13.730 −4.087 1.00 39.46 O ATOM 284 CG2 THR D 364 0.991 14.328 −5.444 1.00 37.70 C ATOM 285 C THR D 364 1.275 12.763 −1.874 1.00 38.47 C ATOM 286 O THR D 364 2.427 12.858 −1.452 1.00 35.55 O ATOM 287 N VAL D 365 0.430 11.843 −1.418 1.00 39.09 N ATOM 288 CA VAL D 365 0.832 10.889 −0.363 1.00 38.75 C ATOM 289 CB VAL D 365 0.120 11.180 0.978 1.00 39.39 C ATOM 290 CG1 VAL D 365 0.534 12.535 1.550 1.00 32.92 C ATOM 291 CG2 VAL D 365 −1.392 11.170 0.774 1.00 36.96 C ATOM 292 C VAL D 365 0.501 9.452 −0.788 1.00 42.90 C ATOM 293 O VAL D 365 −0.470 9.218 −1.523 1.00 42.04 O ATOM 294 N TYR D 366 1.300 8.486 −0.327 1.00 39.07 N ATOM 295 CA TYR D 366 1.034 7.080 −0.654 1.00 36.94 C ATOM 296 CB TYR D 366 2.202 6.194 −0.251 1.00 35.53 C ATOM 297 CG TYR D 366 3.417 6.305 −1.144 1.00 38.31 C ATOM 298 CD1 TYR D 366 3.355 5.936 −2.461 1.00 35.27 C ATOM 299 CE1 TYR D 366 4.485 5.986 −3.266 1.00 41.62 C ATOM 300 CZ TYR D 366 5.708 6.440 −2.738 1.00 39.52 C ATOM 301 OH TYR D 366 6.828 6.512 −3.537 1.00 43.05 O ATOM 302 CE2 TYR D 366 5.780 6.825 −1.433 1.00 38.78 C ATOM 303 CD2 TYR D 366 4.633 6.749 −0.635 1.00 40.22 C ATOM 304 C TYR D 366 −0.236 6.485 −0.040 1.00 36.53 C ATOM 305 O TYR D 366 −0.811 5.546 −0.607 1.00 36.31 O ATOM 306 N LYS D 367 −0.661 7.019 1.101 1.00 37.66 N ATOM 307 CA LYS D 367 −1.670 6.372 1.966 1.00 35.38 C ATOM 308 CB LYS D 367 −0.965 5.543 3.026 1.00 38.11 C ATOM 309 CG LYS D 367 −0.436 4.217 2.493 1.00 41.05 C ATOM 310 CD LYS D 367 −1.614 3.256 2.343 1.00 36.63 C ATOM 311 CE LYS D 367 −1.182 1.988 1.668 1.00 40.20 C ATOM 312 NZ LYS D 367 −2.253 0.942 1.671 1.00 31.91 N ATOM 313 C LYS D 367 −2.459 7.463 2.678 1.00 38.13 C ATOM 314 O LYS D 367 −1.894 8.493 3.058 1.00 35.35 O ATOM 315 N ALA D 368 −3.762 7.239 2.852 1.00 37.55 N ATOM 316 CA ALA D 368 −4.611 8.184 3.545 1.00 36.54 C ATOM 317 CB ALA D 368 −5.122 9.273 2.599 1.00 33.79 C ATOM 318 C ALA D 368 −5.755 7.443 4.206 1.00 40.87 C ATOM 319 O ALA D 368 −6.066 6.270 3.855 1.00 43.72 O ATOM 320 N SER D 369 −6.341 8.093 5.206 1.00 37.45 N ATOM 321 CA SER D 369 −7.318 7.408 6.046 1.00 41.38 C ATOM 322 CB SER D 369 −6.699 7.157 7.407 1.00 39.35 C ATOM 323 OG SER D 369 −6.208 8.382 7.910 1.00 39.78 O ATOM 324 C SER D 369 −8.576 8.261 6.232 1.00 40.88 C ATOM 325 O SER D 369 −8.511 9.483 6.118 1.00 40.71 O ATOM 326 N ASN D 370 −9.704 7.610 6.527 1.00 39.09 N ATOM 327 CA ASN D 370 −10.904 8.288 6.977 1.00 40.01 C ATOM 328 CB ASN D 370 −10.580 9.133 8.230 1.00 37.02 C ATOM 329 CG ASN D 370 −10.023 8.298 9.379 1.00 41.00 C ATOM 330 OD1 ASN D 370 −9.061 8.703 10.045 1.00 46.22 O ATOM 331 ND2 ASN D 370 −10.642 7.156 9.653 1.00 34.91 N ATOM 332 C ASN D 370 −11.526 9.176 5.902 1.00 39.22 C ATOM 333 O ASN D 370 −12.187 10.154 6.233 1.00 41.94 O ATOM 334 N LEU D 371 −11.277 8.844 4.633 1.00 39.96 N ATOM 335 CA ASN D 371 −11.895 9.514 3.478 1.00 39.72 C ATOM 336 CB ASN D 371 −10.846 9.841 .2.411 1.00 39.71 C ATOM 337 CG ASN D 371 −9.838 10.877 2.862 1.00 46.23 C ATOM 338 CD1 ASN D 371 −8.630 10.941 1.912 1.00 46.82 C ATOM 339 CD2 ASN D 371 −10.554 12.248 2.980 1.00 40.38 C ATOM 340 C ASN D 371 −12.993 8.626 2.875 1.00 42.32 C ATOM 341 O LEU D 371 −12.897 7.403 2.907 1.00 43.33 0 ATOM 342 N ASN D 372 −14.052 9.254 2.353 1.00 43.09 N ATOM 343 CA ASN D 372 −15.061 8.551 1.613 1.00 41.55 C ATOM 344 CB ASN D 372 −16.425 8.994 2.092 1.00 60.96 C ATOM 345 CG ASN D 372 −17.477 7.948 1.854 1.00 83.91 C ATOM 346 OD1 ASN D 372 −17.369 7.139 0.903 1.00 97.06 O ATOM 347 ND2 ASN D 372 −18.514 7.943 2.726 1.00 100.60 N ATOM 348 C ASN D 372 −14.865 8.887 0.141 1.00 41.59 C ATOM 349 O ASN D 372 −14.626 10.039 −0.218 1.00 35.99 O ATOM 350 N LEU D 373 −14.926 7.874 −0.696 1.00 39.15 N ATOM 351 CA LEU D 373 −14.715 8.019 −2.132 1.00 45.44 C ATOM 352 CB LEU D 373 −14.082 6.750 −2.696 1.00 41.00 C ATOM 353 CG LEU D 373 −12.629 6.605 −2.294 1.00 43.32 C ATOM 354 CD1 LEU D 373 −12.054 5.283 −2.839 1.00 43.67 C ATOM 355 CD2 LEU D 373 −11.930 7.826 −2.876 1.00 39.94 C ATOM 356 C LEU D 373 −16.059 8.158 −2.756 1.00 42.30 C ATOM 357 O LEU D 373 −16.950 7.403 −2.402 1.00 44.24 O ATOM 358 N ILE D 374 −16.193 9.140 −3.646 1.00 43.01 N ATOM 359 CA ILE D 374 −17.456 9.519 −4.303 1.00 48.13 C ATOM 360 CB ILE D 374 −17.662 11.062 −4.241 1.00 49.81 C ATOM 361 CG1 ILE D 374 −17.615 11.564 −2.798 1.00 52.05 C ATOM 362 CD1 ILE D 374 −18.683 10.926 −1.906 1.00 55.93 C ATOM 363 CG2 ILE D 374 −18.985 11.484 −4.864 1.00 51.81 C ATOM 364 C ILE D 374 −17.444 9.080 −5.769 1.00 51.44 C ATOM 365 O ILE D 374 −16.584 9.510 −6.553 1.00 48.09 O ATOM 366 N GLY D 375 −18.393 8.225 −6.140 1.00 53.31 N ATOM 367 CA GLY D 375 −18.530 7.774 −7.525 1.00 51.35 C ATOM 368 C GLY D 375 −17.399 6.856 −7.948 1.00 60.66 C ATOM 369 O GLY D 375 −16.756 6.261 −7.095 1.00 53.98 O ATOM 370 N ARG D 376 −17.165 6.727 −9.263 1.00 63.05 N ATOM 371 CA ARG D 376 −16.105 5.852 −9.794 1.00 63.00 C ATOM 372 CB ARG D 376 −16.702 4.795 −10.726 1.00 77.33 C ATOM 373 CG ARG D 376 −16.828 3.412 −10.077 1.00 95.98 C ATOM 374 CD ARG D 376 −17.982 2.607 −10.659 1.00 106.73 C ATOM 375 NE ARG D 376 −19.238 3.371 −10.650 1.00 113.18 N ATOM 376 CZ ARG D 376 −20.104 3.408 −9.636 1.00 116.94 C ATOM 377 NH1 ARG D 376 −19.875 2.720 −8.523 1.00 117.62 N ATOM 378 NH2 ARG D 376 −21.209 4.136 −9.736 1.00 118.46 N ATOM 379 C ARG D 376 −14.940 6.591 −10.488 1.00 57.87 C ATOM 380 O ARG D 376 −15.070 7.754 −10.918 1.00 55.41 O ATOM 381 N PRO D 377 −13.786 5.926 −10.613 1.00 54.88 N ATOM 382 CA PRO D 377 −12.634 6.681 −11.146 1.00 49.44 C ATOM 383 CB PRO D 377 −11.522 5.619 −11.266 1.00 52.32 C ATOM 384 CG PRO D 377 −12.137 4.293 −10.854 1.00 49.53 C ATOM 385 CD PRO D 377 −13.447 4.558 −10.179 1.00 47.67 C ATOM 386 C PRO D 377 −12.957 7.337 −12.519 1.00 55.60 C ATOM 387 O PRO D 377 −13.724 6.777 −13.313 1.00 53.18 O ATOM 388 N SER D 378 −12.398 8.518 −12.787 1.00 48.60 N ATOM 389 CA SER D 378 −12.622 9.211 −14.072 1.00 45.64 C ATOM 390 CB SER D 378 −13.476 10.463 −13.846 1.00 41.40 C ATOM 391 OG SER D 378 −13.537 11.269 −15.016 1.00 48.26 O ATOM 392 C SER D 378 −11.304 9.636 −14.673 1.00 45.17 C ATOM 393 O SER D 378 −10.420 10.051 −13.933 1.00 46.90 O ATOM 394 N THR D 379 −11.155 9.553 −16.001 1.00 45.76 N ATOM 395 CA THR D 379 −9.981 10.138 −16.657 1.00 50.65 C ATOM 396 CB THR D 379 −9.368 9.217 −17.731 1.00 52.80 C ATOM 397 OG1 THR D 379 −10.421 8.681 −18.531 1.00 59.91 O ATOM 398 CG2 THR D 379 −8.549 8.062 −17.106 1.00 55.70 C ATOM 399 C THR D 379 −10.229 11.515 −17.305 1.00 54.20 C ATOM 400 O THR D 379 −9.394 11.971 −18.089 1.00 57.96 O ATOM 401 N VAL D 380 −11.342 12.176 −17.001 1.00 52.30 N ATOM 402 CA VAL D 380 −11.613 13.514 −17.586 1.00 49.06 C ATOM 403 CB VAL D 380 −13.090 13.921 −17.452 1.00 58.92 C ATOM 404 CG1 VAL D 380 −13.295 15.250 −18.165 1.00 52.92 C ATOM 405 CG2 VAL D 380 −14.018 12.826 −18.024 1.00 43.39 C ATOM 406 C VAL D 380 −10.732 14.632 −17.010 1.00 49.46 C ATOM 407 O VAL D 380 −10.798 14.906 −15.840 1.00 45.09 O ATOM 408 N HIS D 381 −9.910 15.275 −17.847 1.00 53.26 N ATOM 409 CA HIS D 381 −8.976 16.354 −17.425 1.00 53.95 C ATOM 410 CB HIS D 381 −9.716 17.676 −17.250 1.00 65.96 C ATOM 411 CG HIS D 381 −10.171 18.287 −18.546 1.00 84.42 C ATOM 412 ND1 HIS D 381 −9.477 19.255 −19.170 1.00 93.36 N ATOM 413 CE1 HIS D 381 −10.115 19.596 −20.308 1.00 91.59 C ATOM 414 NE2 HIS D 381 −11.219 18.832 −20.414 1.00 90.03 N ATOM 415 CD2 HIS D 381 −11.283 18.013 −19.350 1.00 88.54 C ATOM 416 C HIS D 381 −8.162 16.078 −16.187 1.00 51.81 C ATOM 417 O HIS D 381 −8.008 16.952 −15.333 1.00 44.62 O ATOM 418 N SER D 382 −7.653 14.853 −16.056 1.00 50.47 N ATOM 419 CA SER D 382 −6.966 14.459 −14.848 1.00 46.86 C ATOM 420 CB SER D 382 −6.538 13.009 −14.963 1.00 48.71 C ATOM 421 OG SER D 382 −5.752 12.678 −13.831 1.00 43.96 O ATOM 422 C SER D 382 −5.734 15.331 −14.635 1.00 50.18 C ATOM 423 O SER D 382 −4.974 15.626 −15.571 1.00 48.42 O ATOM 424 N TRP D 383 −5.530 15.740 −13.400 1.00 52.27 N ATOM 425 CA TRP D 383 −4.386 16.566 −13.062 1.00 54.54 C ATOM 426 CB TRP D 383 −4.544 17.206 −11.697 1.00 50.70 C ATOM 427 CG TRP D 383 −5.514 18.336 −11.624 1.00 53.73 C ATOM 428 CD1 TRP D 383 −6.380 18.798 −12.620 1.00 54.90 C ATOM 429 NE1 TRP D 383 −7.163 19.826 −12.147 1.00 51.82 N ATOM 430 CE2 TRP D 383 −6.890 20.075 −10.840 1.00 52.80 C ATOM 431 CD2 TRP D 383 −5.823 19.148 −10.438 1.00 54.50 C ATOM 432 CE3 TRP D 383 −5.358 19.180 −9.120 1.00 59.36 C ATOM 433 CZ3 TRP D 383 −5.905 20.120 −8.233 1.00 59.86 C ATOM 434 CH2 TRP D 383 −6.907 21.021 −8.646 1.00 59.60 C ATOM 435 CZ2 TRP D 383 −7.415 21.015 −9.960 1.00 55.96 C ATOM 436 C TRP D 383 −3.105 15.795 −13.030 1.00 57.94 C ATOM 437 O TRP D 383 −2.072 16.416 −12.884 1.00 59.08 O ATOM 438 N PHE D 384 −3.164 14.457 −13.086 1.00 50.79 N ATOM 439 CA PHE D 384 −1.970 13.623 −13.224 1.00 42.57 C ATOM 440 CB PHE D 384 −1.587 12.887 −11.910 1.00 44.85 C ATOM 441 CG PHE D 384 −1.349 13.807 −10.713 1.00 42.92 C ATOM 442 CD1 PHE D 384 −0.057 14.251 −10.385 1.00 49.71 C ATOM 443 CE1 PHE D 384 −0.178 15.082 −9.276 1.00 44.42 C ATOM 444 CZ PHE D 384 −0.887 15.481 −8.476 1.00 39.31 C ATOM 445 CE2 PHE D 384 −2.163 15.032 −8.772 1.00 36.25 C ATOM 446 CD2 PHE D 384 −2.399 14.197 −9.882 1.00 40.18 C ATOM 447 C PHE D 384 −2.220 12.629 −14.344 1.00 41.35 C ATOM 448 O PHE D 384 −2.713 11.521 −14.105 1.00 42.65 O ATOM 449 N PRO D 385 −1.863 13.013 −15.589 1.00 44.97 N ATOM 450 CA PRO D 385 −2.053 12.210 −16.802 1.00 42.45 C ATOM 451 CB PRO D 385 −1.156 12.920 −17.843 1.00 44.36 C ATOM 452 CG PRO D 385 −1.071 14.337 −17.353 1.00 50.89 C ATOM 453 CD PRO D 385 −1.091 14.255 −15.853 1.00 48.53 C ATOM 454 C PRO D 385 −1.536 10.801 −16.604 1.00 42.33 C ATOM 455 O PRO D 385 −0.432 10.636 −16.099 1.00 50.35 O ATOM 456 N GLY D 386 −2.274 9.795 −17.038 1.00 38.27 N ATOM 457 CA GLY D 386 −1.931 8.404 −16.702 1.00 42.50 C ATOM 458 C GLY D 386 −2.665 7.859 −15.475 1.00 43.67 C ATOM 459 O GLY D 386 −2.632 6.637 −15.242 1.00 53.89 O ATOM 460 N TYR D 387 −3.316 8.747 −14.707 1.00 40.11 N ATOM 461 CA TYR D 387 −4.195 8.374 −13.557 1.00 43.85 C ATOM 462 CB TYR D 387 −3.653 8.934 −12.250 1.00 41.31 C ATOM 463 CG TYR D 387 −2.323 8.374 −11.869 1.00 39.68 C ATOM 464 CD1 TYR D 387 −2.243 7.258 −11.020 1.00 38.46 C ATOM 465 CE1 TYR D 387 −1.012 6.738 −10.633 1.00 36.60 C ATOM 466 CZ TYR D 387 0.161 7.295 −11.112 1.00 38.29 C ATOM 467 OH TYR D 387 1.355 6.741 −10.698 1.00 36.98 O ATOM 468 CE2 TYR D 387 0.123 8.422 −11.968 1.00 36.77 C ATOM 469 CD2 TYR D 387 −1.138 8.955 −12.332 1.00 35.98 C ATOM 470 C TYR D 387 −5.618 8.908 −13.664 1.00 45.38 C ATOM 471 O TYR D 387 −5.859 10.031 −14.149 1.00 43.20 O ATOM 472 N ALA D 388 −6.542 8.105 −13.164 1.00 42.87 N ATOM 473 CA ALA D 388 −7.945 8.457 −13.058 1.00 42.04 C ATOM 474 CB ALA D 388 −8.803 7.219 −13.258 1.00 43.84 C ATOM 475 C ALA D 388 −8.105 8.982 −11.638 1.00 42.38 C ATOM 476 O ALA D 388 −7.279 8.688 −10.765 1.00 41.27 O ATOM 477 N TRP D 389 −9.141 9.780 −11.397 1.00 36.99 N ATOM 478 CA TRP D 389 −9.271 10.391 −10.125 1.00 38.00 C ATOM 479 CB TRP D 389 −9.011 11.904 −10.260 1.00 41.25 C ATOM 480 CG TRP D 389 −9.824 12.546 −11.350 1.00 41.91 C ATOM 481 CD1 TRP D 389 −9.432 12.777 −12.682 1.00 46.68 C ATOM 482 NE1 TRP D 389 −10.436 13.380 −13.394 1.00 40.83 N ATOM 483 CE2 TRP D 389 −11.525 13.582 −12.611 1.00 43.61 C ATOM 484 CD2 TRP D 389 −11.196 13.053 −11.262 1.00 38.53 C ATOM 485 CE3 TRP D 389 −12.162 13.123 −10.249 1.00 42.34 C ATOM 486 CZ3 TRP D 389 −13.425 13.708 −10.563 1.00 44.28 C ATOM 487 CH2 TRP D 389 −13.711 14.200 −11.861 1.00 42.67 C ATOM 488 CZ2 TRP D 389 −12.771 14.131 −12.911 1.00 40.00 C ATOM 489 C TRP D 389 −10.629 10.049 −9.583 1.00 40.55 C ATOM 490 O TRP D 389 −11.539 9.689 −10.331 1.00 43.50 O ATOM 491 N THR D 390 −10.780 10.105 −8.272 1.00 42.62 N ATOM 492 CA THR D 390 −12.090 9.887 −7.642 1.00 40.01 C ATOM 493 CB THR D 390 −12.226 8.452 −7.030 1.00 46.04 C ATOM 494 OG1 THR D 390 −11.890 7.460 −8.012 1.00 48.23 O ATOM 495 CG2 THR D 390 −13.677 8.182 −6.494 1.00 38.86 C ATOM 496 C THR D 390 −12.091 10.876 −6.500 1.00 39.38 C ATOM 497 O THR D 390 −11.141 10.920 −5.695 1.00 40.56 O ATOM 498 N ILE D 391 −13.130 11.684 −6.440 1.00 41.62 N ATOM 499 CA ILE D 391 −13.316 12.674 −5.359 1.00 40.76 C ATOM 500 CB ILE D 391 −14.666 13.482 −5.525 1.00 41.33 C ATOM 501 CG1 ILE D 391 −14.584 14.425 −6.743 1.00 45.36 C ATOM 502 CD1 ILE D 391 −15.924 14.737 −7.389 1.00 49.09 C ATOM 503 CG2 ILE D 391 −14.974 14.394 −4.326 1.00 37.13 C ATOM 504 C ILE D 391 −13.260 11.973 −4.015 1.00 42.74 C ATOM 505 O ILE D 391 −13.914 10.940 −3.808 1.00 39.42 O ATOM 506 N ALA D 392 −12.534 12.587 −3.082 1.00 38.01 N ATOM 507 CA ALA D 392 −12.400 12.019 −1.758 1.00 39.29 C ATOM 508 CB ALA D 392 −10.935 11.681 −1.500 1.00 29.28 C ATOM 509 C ALA D 392 −12.852 13.110 −0.789 1.00 42.75 C ATOM 510 O ALA D 392 −12.394 14.239 −0.890 1.00 37.28 O ATOM 511 N GLN D 393 −13.702 12.769 0.171 1.00 41.74 N ATOM 512 CA GLN D 393 −14.149 13.770 1.122 1.00 42.74 C ATOM 513 CB GLN D 393 −15.574 14.200 0.742 1.00 47.76 C ATOM 514 CG GLN D 393 −16.642 13.237 1.256 1.00 48.89 C ATOM 515 CD GLN D 393 −18.051 13.497 0.718 1.00 51.53 C ATOM 516 OE1 GLN D 393 −18.270 14.303 −0.212 1.00 50.62 O ATOM 517 NE2 GLN D 393 −19.016 12.787 1.300 1.00 45.92 N ATOM 518 C GLN D 393 −14.059 13.221 2.559 1.00 39.76 C ATOM 519 O GLN D 393 −14.148 12.031 2.780 1.00 41.47 O ATOM 520 N CYS D 394 −13.879 14.086 3.551 1.00 44.74 N ATOM 521 CA CYS D 394 −13.650 13.608 4.915 1.00 42.99 C ATOM 522 CB CYS D 394 −13.417 14.783 5.850 1.00 47.08 C ATOM 523 SG CYS D 394 −13.518 14.299 7.582 1.00 43.84 S ATOM 524 C CYS D 394 −14.844 12.817 5.385 1.00 44.07 C ATOM 525 O CYS D 394 −15.977 13.233 5.150 1.00 40.98 O ATOM 526 N LYS D 395 −14.628 11.668 6.031 1.00 42.19 N ATOM 527 CA LYS D 395 −15.783 10.888 6.476 1.00 43.20 C ATOM 528 CB LYS D 395 −15.439 9.413 6.727 1.00 47.27 C ATOM 529 CG LYS D 395 −15.180 8.968 8.162 1.00 59.07 C ATOM 530 CD LYS D 395 −15.579 7.496 8.372 1.00 60.30 C ATOM 531 CE LYS D 395 −14.678 9.802 9.406 1.00 64.42 C ATOM 532 NZ LYS D 395 −13.411 6.224 8.811 1.00 55.03 N ATOM 533 C LYS D 395 −16.595 11.499 7.637 1.00 46.36 C ATOM 534 O LYS D 395 −17.764 11.176 7.822 1.00 41.91 O ATOM 535 N ILE D 396 −15.978 12.348 8.447 1.00 47.11 N ATOM 536 CA ILE D 396 −16.734 12.978 9.550 1.00 48.08 C ATOM 537 CB ILE D 396 −15.826 13.524 10.668 1.00 42.20 C ATOM 538 CG1 ILE D 396 −15.330 12.401 11.564 1.00 41.23 C ATOM 539 CD1 ILE D 396 −14.976 11.064 10.920 1.00 42.65 C ATOM 540 CG2 ILE D 396 −16.590 14.544 11.535 1.00 43.94 C ATOM 541 C ILE D 396 −17.636 14.106 9.060 1.00 47.33 C ATOM 542 O ILE D 396 −18.845 14.116 9.348 1.00 51.46 O ATOM 543 N CYS D 397 −17.051 15.039 8.320 1.00 46.61 N ATOM 544 CA CYS D 397 −17.767 16.287 7.972 1.00 47.51 C ATOM 545 CB CYS D 397 −16.956 17.468 8.475 1.00 41.13 C ATOM 546 SG CYS D 397 −15.425 17.685 7.558 1.00 49.86 S ATOM 547 C CYS D 397 −18.057 16.477 6.477 1.00 49.04 C ATOM 548 O CYS D 397 −18.652 17.493 6.104 1.00 44.62 O ATOM 549 N ALA D 398 −17.619 15.522 5.636 1.00 40.01 N ATOM 550 CA ALA D 398 −17.849 15.531 4.175 1.00 42.02 C ATOM 551 CB ALA D 398 −19.337 15.407 3.824 1.00 44.31 C ATOM 552 C ALA D 398 −17.196 16.678 3.429 1.00 41.97 C ATOM 553 O ALA D 398 −17.464 16.912 2.231 1.00 48.25 O ATOM 554 N SER D 399 −16.300 17.377 4.115 1.00 43.92 N ATOM 555 CA SER D 399 −15.410 18.318 3.428 1.00 45.15 C ATOM 556 CB SER D 399 −14.559 19.044 4.469 1.00 52.47 C ATOM 557 OG SER D 399 −13.484 19.731 3.870 1.00 60.55 O ATOM 558 C SER D 399 −14.552 17.652 2.298 1.00 51.34 C ATOM 559 O SER D 399 −14.106 16.486 2.414 1.00 45.92 O ATOM 560 N HIS D 400 −14.379 18.384 1.191 1.00 50.86 N ATOM 561 CA HIS D 400 −13.648 17.918 0.022 1.00 54.81 C ATOM 562 CB HIS D 400 −14.102 18.690 −1.220 1.00 61.57 C ATOM 563 CG HIS D 400 −15.394 18.180 −1.803 1.00 78.23 C ATOM 564 ND1 HIS D 400 −16.556 18.195 −1.116 1.00 84.09 N ATOM 565 CE1 HIS D 400 −17.534 17.672 −1.885 1.00 90.14 C ATOM 566 NE2 HIS D 400 −16.993 17.320 −3.070 1.00 86.52 N ATOM 567 CD2 HIS D 400 −15.679 17.616 −3.052 1.00 82.95 C ATOM 568 C HIS D 400 −12.150 18.031 0.175 1.00 53.59 C ATOM 569 O HIS D 400 −11.571 19.105 −0.026 1.00 53.51 O ATOM 570 N ILE D 401 −11.499 16.913 0.481 1.00 47.50 N ATOM 571 CA ILE D 401 −10.083 16.951 0.822 1.00 45.10 C ATOM 572 CB ILE D 401 −9.728 15.921 1.911 1.00 42.94 C ATOM 573 CG1 ILE D 401 −10.757 15.997 3.045 1.00 45.50 C ATOM 574 CD1 ILE D 401 −10.668 17.273 3.885 1.00 39.69 C ATOM 575 CG2 ILE D 401 −8.354 16.203 2.466 1.00 37.75 C ATOM 576 C ILE D 401 −9.223 16.857 −0.435 1.00 44.49 C ATOM 577 O ILE D 401 −8.246 17.590 −0.563 1.00 42.61 O ATOM 578 N GLY D 402 −9.617 16.012 −1.392 1.00 42.46 N ATOM 579 CA GLY D 402 −8.882 15.932 −2.657 1.00 39.09 C ATOM 580 C GLY D 402 −9.381 14.750 −3.451 1.00 41.48 C ATOM 581 O GLY D 402 −10.584 14.539 −3.537 1.00 41.87 O ATOM 582 N TRP D 403 −8.457 13.957 −3.988 1.00 36.54 N ATOM 583 CA TRP D 403 −8.792 12.842 −4.873 1.00 40.48 C ATOM 584 CB TRP D 403 −8.616 13.271 −6.336 1.00 37.91 C ATOM 585 CG TRP D 403 −9.384 14.512 −6.666 1.00 42.10 C ATOM 586 CD1 TRP D 403 −10.648 14.605 −7.249 1.00 41.93 C ATOM 587 NE1 TRP D 403 −11.035 15.908 −7.371 1.00 41.26 N ATOM 588 CE2 TRP D 403 −10.083 16.744 −6.891 1.00 43.17 C ATOM 589 CD2 TRP D 403 −8.983 15.900 −6.399 1.00 44.10 C ATOM 590 CE3 TRP D 403 −7.852 16.513 −5.824 1.00 46.41 C ATOM 591 CZ3 TRP D 403 −7.833 17.926 −5.742 1.00 50.37 C ATOM 592 CH2 TRP D 403 −8.923 18.707 −6.191 1.00 45.40 C ATOM 593 CZ2 TRP D 403 −10.060 18.132 −6.775 1.00 41.77 C ATOM 594 C TRP D 403 −7.891 11.625 −4.628 1.00 40.57 C ATOM 595 O TRP D 403 −6.745 11.748 −4.208 1.00 38.29 O ATOM 596 N LYS D 404 −8.434 10.453 −4.885 1.00 38.50 N ATOM 597 CA LYS D 404 −7.677 9.229 −5.005 1.00 42.00 C ATOM 598 CB LYS D 404 −8.509 8.029 −4.551 1.00 42.95 C ATOM 599 CG LYS D 404 −7.693 6.731 −4.510 1.00 44.50 C ATOM 600 CD LYS D 404 −8.558 5.507 −4.293 1.00 39.95 C ATOM 601 CE LYS D 404 −7.774 4.405 −3.602 1.00 44.57 C ATOM 602 NZ LYS D 404 −8.598 3.165 −3.496 1.00 53.29 N ATOM 603 C LYS D 404 −7.378 9.036 −6.472 1.00 37.59 C ATOM 604 O LYS D 404 −8.281 9.143 −7.282 1.00 42.46 O ATOM 605 N PHE D 405 −6.112 8.780 −6.794 1.00 36.10 N ATOM 606 CA PHE D 405 −5.652 8.599 −8.167 1.00 34.19 C ATOM 607 CB PHE D 405 −4.438 9.502 −8.424 1.00 29.96 C ATOM 608 CG PHE D 405 −4.804 10.945 −8.531 1.00 32.29 C ATOM 609 CD1 PHE D 405 −5.256 11.469 −9.748 1.00 33.11 C ATOM 610 CE1 PHE D 405 −5.649 12.815 −9.852 1.00 35.15 C ATOM 611 CZ PHE D 405 −5.585 13.654 −8.734 1.00 31.06 C ATOM 612 CE2 PHE D 405 −5.110 13.140 −7.516 1.00 33.07 C ATOM 613 CD2 PHE D 405 −4.766 11.785 −7.400 1.00 27.95 C ATOM 614 C PHE D 405 −5.263 7.147 −8.372 1.00 39.42 C ATOM 615 O PHE D 405 −4.500 6.567 −7.550 1.00 39.39 O ATOM 616 N THR D 406 −5.772 6.580 −9.461 1.00 37.16 N ATOM 617 CA THR D 406 −5.612 5.159 −9.759 1.00 46.82 C ATOM 618 CB THR D 406 −6.958 4.428 −9.571 1.00 48.0 C ATOM 619 OG1 THR D 406 −7.994 5.162 −10.241 1.00 42.68 O ATOM 620 CG2 THR D 406 −7.315 4.392 −8.060 1.00 45.15 C ATOM 621 C THR D 406 −5.025 4.986 −11.174 1.00 47.06 C ATOM 622 O THR D 406 −5.504 5.589 −12.125 1.00 47.37 O ATOM 623 N ALA D 407 −3.934 4.232 −11.286 1.00 50.53 N ATOM 624 CA ALA D 407 −3.209 4.107 −12.559 1.00 47.98 C ATOM 625 CB ALA D 407 −1.893 3.360 −12.359 1.00 43.70 C ATOM 626 C ALA D 407 −4.046 3.455 −13.660 1.00 47.47 C ATOM 627 O ALA D 407 −4.741 2.490 −13.417 1.00 47.99 O ATOM 628 N THR D 408 −3.995 4.004 −14.867 1.00 50.73 N ATOM 629 CA THR D 408 −4.638 3.368 −16.019 1.00 48.90 C ATOM 630 CB THR D 408 −4.865 4.390 −17.148 1.00 52.90 C ATOM 631 OG1 THR D 408 −3.604 4.736 −17.718 1.00 65.03 O ATOM 632 CG2 THR D 408 −5.528 5.665 −16.633 1.00 48.66 C ATOM 633 C THR D 408 −3.818 2.180 −16.588 1.00 55.73 C ATOM 634 O THR D 408 −4.393 1.297 −17.220 1.00 65.03 O ATOM 635 N LYS D 409 −2.495 2.164 −16.370 1.00 43.84 N ATOM 636 CA LYS D 409 −1.614 1.121 −16.904 1.00 48.40 C ATOM 637 CB LYS D 409 −0.568 1.703 −17.872 1.00 51.56 C ATOM 638 CG LYS D 409 −1.173 2.110 −19.221 1.00 59.85 C ATOM 639 CD LYS D 409 −0.410 3.235 −19.904 1.00 61.89 C ATOM 640 CE LYS D 409 −0.731 2.718 −20.772 1.00 68.88 C ATOM 641 NZ LYS D 409 −2.036 2.799 −20.050 1.00 75.28 N ATOM 642 C LYS D 409 −0.919 0.421 −15.753 1.00 51.14 C ATOM 643 O LYS D 409 −0.483 1.075 −14.788 1.00 44.23 O ATOM 644 N LYS D 410 −0.824 −0.900 −15.868 1.00 46.98 N ATOM 645 CA LYS D 410 −0.291 −1.747 −14.805 1.00 55.57 C ATOM 646 CB LYS D 410 −0.725 −3.220 −14.948 1.00 59.07 C ATOM 647 CG LYS D 410 −2.012 −3.489 −14.171 1.00 71.02 C ATOM 648 CD LYS D 410 −2.625 −4.838 −14.509 1.00 84.77 C ATOM 649 CE LYS D 410 −4.135 −4.829 −14.275 1.00 84.74 C ATOM 650 NZ LYS D 410 −4.805 −5.993 −14.930 1.00 73.33 N ATOM 651 C LYS D 410 1.201 −1.639 −14.656 1.00 48.11 C ATOM 652 O LYS D 410 1.733 −2.047 −13.626 1.00 50.91 O ATOM 653 N ASP D 411 1.867 −1.040 −15.634 1.00 44.66 N ATOM 654 CA ASP D 411 3.312 −0.918 −15.543 1.00 51.79 C ATOM 655 CB ASP D 411 3.940 −0.997 −16.936 1.00 54.31 C ATOM 656 CG ASP D 411 3.753 0.282 −17.724 1.00 66.92 C ATOM 657 OD1 ASP D 411 2.809 1.046 −17.407 1.00 66.28 O ATOM 658 OD2 ASP D 411 4.560 0.538 −18.648 1.00 66.53 O ATOM 659 C ASP D 411 3.827 0.332 −14.774 1.00 52.63 C ATOM 660 O ASP D 411 5.030 0.484 −14.659 1.00 50.01 O ATOM 661 N MET D 412 2.922 1.203 −14.285 1.00 52.18 N ATOM 662 CA MET D 412 3.228 2.462 −13.535 1.00 51.12 C ATOM 663 CB MET D 412 2.043 3.462 −13.622 1.00 43.95 C ATOM 664 CG MET D 412 1.655 3.867 −15.059 1.00 53.82 C ATOM 665 SD MET D 412 0.110 4.811 −15.230 1.00 54.87 S ATOM 666 CE MET D 412 0.258 5.437 −16.910 1.00 72.85 C ATOM 667 C MET D 412 3.498 2.163 −12.050 1.00 52.53 C ATOM 668 O MET D 412 3.096 1.21 −11.566 1.00 45.87 O ATOM 669 N SER D 413 4.173 3.083 −11.350 1.00 42.79 N ATOM 670 CA SER D 413 4.338 3.032 −9.890 1.00 44.77 C ATOM 671 CB SER D 413 5.660 2.390 −9.467 1.00 38.64 C ATOM 672 OG SER D 413 6.756 3.225 −9.841 1.00 43.86 O ATOM 673 C SER D 413 4.330 4.482 −9.409 1.00 43.78 C ATOM 674 O SER D 413 4.971 5.343 −10.033 1.00 41.02 O ATOM 675 N PRO D 414 3.599 4.760 −8.316 1.00 41.67 N ATOM 676 CA PRO D 414 2.765 3.778 −7.629 1.00 38.99 C ATOM 677 CB PRO D 414 2.460 4.468 −6.282 1.00 36.69 C ATOM 678 CG PRO D 414 2.520 5.926 −6.576 1.00 37.60 C ATOM 679 CD PRO D 414 3.585 6.081 −7.640 1.00 40.40 C ATOM 680 C PRO D 414 1.485 3.560 −8.437 1.00 41.67 C ATOM 681 O PRO D 414 1.142 4.428 −9.245 1.00 37.86 O ATOM 682 N GLN D 415 0.812 2.413 −8.258 1.00 41.52 N ATOM 683 CA GLN D 415 −0.457 2.115 −8.923 1.00 39.90 C ATOM 684 CB GLN D 415 −0.856 0.642 −7.743 1.00 40.25 C ATOM 685 CG GLN D 415 −0.038 −0.315 −9.645 1.00 46.99 C ATOM 686 CD GLN D 415 −0.534 −0.221 −11.08 1.00 45.75 C ATOM 687 OE1 GLN D 415 0.074 0.443 −11.919 1.00 47.06 O ATOM 688 NE2 GLN D 415 −1.680 −0.781 −11.346 1.00 44.81 N ATOM 689 C GLN D 415 −1.575 2.997 −8.380 1.00 45.16 C ATOM 690 O GLN D 415 −2.599 3.211 −9.052 1.00 40.41 O ATOM 691 N LYS D 416 −1.383 3.497 −7.157 1.00 40.90 N ATOM 692 CA LYS D 416 −2.377 4.357 −6.547 1.00 38.81 C ATOM 693 CB LYS D 416 −3.413 3.545 −5.788 1.00 40.96 C ATOM 694 CG LYS D 416 −3.221 3.550 −4.291 1.00 46.93 C ATOM 695 CD LYS D 416 −4.224 2.645 −3.604 1.00 58.00 C ATOM 696 CE LYS D 416 −3.684 1.249 −3.310 1.00 61.52 C ATOM 697 NZ LYS D 416 −4.170 0.286 −4.344 1.00 61.46 N ATOM 698 C LYS D 416 −1.716 5.371 −5.643 1.00 36.91 C ATOM 699 O LYS D 416 −0.654 5.125 −5.069 1.00 39.65 O ATOM 700 N PHE D 417 −2.320 6.546 −5.547 1.00 39.07 N ATOM 701 CA PHE D 417 −1.925 7.523 −4.536 1.00 37.64 C ATOM 702 CB PHE D 417 −0.646 8.263 −4.918 1.00 34.93 C ATOM 703 CG PHE D 417 −0.787 9.161 −6.127 1.00 36.63 C ATOM 704 CD1 PHE D 417 −0.990 10.526 −5.972 1.00 36.94 C ATOM 705 CE1 PHE D 417 −1.108 11.353 −7.059 1.00 38.17 C ATOM 706 CZ PHE D 417 −0.980 10.826 −8.339 1.00 38.78 C ATOM 707 CE2 PHE D 417 −0.722 9.475 −8.499 1.00 40.57 C ATOM 708 CD2 PHE D 417 −0.629 8.654 −7.392 1.00 32.68 C ATOM 709 C PHE D 417 −3.054 8.489 −4.272 1.00 37.38 C ATOM 710 O PHE D 417 −4.091 8.425 −4.945 1.00 39.45 O ATOM 711 N TRP D 418 −2.853 9.369 −3.284 1.00 36.23 N ATOM 712 CA TRP D 418 −3.817 10.438 −3.005 1.00 35.46 C ATOM 713 CB TRP D 418 −4.232 10.374 −1.542 1.00 37.90 C ATOM 714 CG TRP D 418 −4.797 9.022 −1.149 1.00 36.92 C ATOM 715 CD1 TRP D 418 −4.085 7.871 −0.809 1.00 34.34 C ATOM 716 NE1 TRP D 418 −4.953 6.830 −0.528 1.00 40.86 N ATOM 717 CE2 TRP D 418 −6.259 7.225 −0.645 1.00 37.10 C ATOM 718 CD2 TRP D 418 −6.239 8.637 −1.057 1.00 36.55 C ATOM 719 CE3 TRP D 418 −7.449 9.294 −1.290 1.00 34.99 C ATOM 720 CZ3 TRP D 418 −8.647 8.600 −1.068 1.00 36.53 C ATOM 721 CH2 TRP D 418 −8.647 7.244 −0.664 1.00 36.09 C ATOM 722 CZ2 TRP D 418 −7.447 6.538 −0.436 1.00 32.77 C ATOM 723 C TRP D 418 −3.236 11.796 −3.301 1.00 39.49 C ATOM 724 O TRP D 418 −2.076 12.102 −2.926 1.00 34.44 O ATOM 725 N GLY D 419 −4.033 12.645 −3.941 1.00 39.81 N ATOM 726 CA GLY D 419 −3.646 14.044 −4.118 1.00 35.88 C ATOM 727 C GLY D 419 −4.574 14.972 −3.357 1.00 38.09 C ATOM 728 O GLY D 419 −5.763 15.079 −3.691 1.00 36.01 O ATOM 729 N LEU D 420 −4.027 15.631 −2.333 1.00 35.20 N ATOM 730 CA LEU D 420 −4.813 16.284 −1.311 1.00 39.17 C ATOM 731 CB LEU D 420 −4.465 15.779 0.113 1.00 33.44 C ATOM 732 CG LEU D 420 −4.481 14.282 0.351 1.00 36.32 C ATOM 733 CD1 LEU D 420 −4.012 13.963 1.766 1.00 33.31 C ATOM 734 CD2 LEU D 420 −5.872 13.716 0.068 1.00 30.06 C ATOM 735 C LEU D 420 −4.583 17.765 −1.331 1.00 41.11 C ATOM 736 O LEU D 420 −3.459 18.224 −1.469 1.00 47.66 O ATOM 737 N THR D 421 −5.650 18.504 −1.077 1.00 41.59 N ATOM 738 CA THR D 421 −5.626 19.948 −1.255 1.00 42.61 C ATOM 739 CB THR D 421 −7.098 20.389 −1.469 1.00 39.99 C ATOM 740 OG1 THR D 421 −7.473 19.935 −2.779 1.00 36.52 O ATOM 741 CG2 THR D 421 −7.267 21.937 −1.387 1.00 37.00 C ATOM 742 C THR D 421 −4.992 20.516 −0.002 1.00 40.83 C ATOM 743 O THR D 421 −5.558 20.333 1.067 1.00 40.91 O ATOM 744 N ARG D 422 −3.810 21.130 −0.086 1.00 43.97 N ATOM 745 CA ARG D 422 −3.107 21.522 1.181 1.00 47.70 C ATOM 746 CB ARG D 422 −1.784 22.256 0.936 1.00 53.26 C ATOM 747 CG ARG D 422 0.851 21.590 −0.061 1.00 58.13 C ATOM 748 CD ARG D 422 0.301 22.512 −0.467 1.00 62.45 C ATOM 749 NE ARG D 422 1.233 21.765 −1.317 1.00 66.62 N ATOM 750 CZ ARG D 422 2.222 21.012 −0.839 1.00 69.30 C ATOM 751 NH1 ARG D 422 2.422 20.932 0.479 1.00 69.64 N ATOM 752 NH2 ARG D 422 3.004 20.338 −1.671 1.00 68.91 N ATOM 753 C ARG D 422 −3.953 22.400 2.089 1.00 45.82 C ATOM 754 O ARG D 422 −3.925 22.254 3.293 1.00 44.86 O ATOM 755 N SER D 423 −4.706 23.327 1.511 1.00 54.61 N ATOM 756 CA SER D 423 −5.417 24.313 2.334 1.00 59.28 C ATOM 757 CB SER D 423 −5.905 25.452 1.455 1.00 56.59 C ATOM 758 OG SER D 423 −6.555 24.911 0.320 1.00 57.41 O ATOM 759 C SER D 423 −6.579 23.682 3.126 1.00 60.54 C ATOM 760 O SER D 423 −7.067 24.276 4.099 1.00 64.65 O ATOM 761 N ALA D 424 −7.007 22.481 2.706 1.00 57.18 N ATOM 762 CA ALA D 424 −7.994 21.682 3.443 1.00 49.63 C ATOM 763 CB ALA D 424 −8.744 20.770 2.483 1.00 47.70 C ATOM 764 C ALA D 424 −7.418 20.887 4.666 1.00 51.41 C ATOM 765 O ALA D 424 −8.166 20.287 5.428 1.00 41.35 O ATOM 766 N LEU D 425 −6.103 20.903 4.872 1.00 47.84 N ATOM 767 CA LEU D 425 −5.516 20.205 6.043 1.00 55.50 C ATOM 768 CB LEU D 425 −4.444 19.194 5.586 1.00 50.02 C ATOM 769 CG LEU D 425 −4.880 18.369 4.380 1.00 54.22 C ATOM 770 CD1 LEU D 425 −3.714 17.651 3.699 1.00 50.36 C ATOM 771 CD2 LEU D 425 −5.975 17.421 4.844 1.00 50.91 C ATOM 772 C LEU D 425 −4.907 21.114 7.126 1.00 58.16 C ATOM 773 O LEU D 425 −4.373 22.179 6.816 1.00 57.38 0 ATOM 774 N LEU D 426 −4.967 20.668 8.384 1.00 60.87 N ATOM 775 CA LEU D 426 −4.254 21.328 9.480 1.00 67.03 C ATOM 776 CB LEU D 426 −5.098 21.377 10.743 1.00 69.83 C ATOM 777 CG LEU D 426 −5.629 22.764 11.119 1.00 82.14 C ATOM 778 CD1 LEU D 426 −5.743 22.807 12.643 1.00 83.61 C ATOM 779 CD2 LEU D 426 −4.747 23.905 10.596 1.00 75.32 C ATOM 780 C LEU D 426 −2.898 20.687 9.772 1.00 67.50 C ATOM 781 O LEU D 426 −2.844 19.470 9.937 1.00 60.80 O ATOM 782 N PRO D 427 −1.888 21.535 10.084 1.00 74.12 N ATOM 783 CA PRO D 427 −0.568 21.863 9.570 1.00 83.22 C ATOM 784 CB PRO D 427 0.311 20.759 10.203 1.00 72.67 C ATOM 785 CG PRO D 427 −0.415 20.397 11.488 1.00 66.90 C ATOM 786 CD PRO D 427 −1.690 21.235 11.518 1.00 77.02 C ATOM 787 C PRO D 427 −0.405 22.046 8.016 1.00 100.76 C ATOM 788 O PRO D 427 −1.283 21.653 7.231 1.00 98.35 O ATOM 789 N THR D 428 0.690 22.696 7.596 1.00 115.94 N ATOM 790 CA THR D 428 1.160 22.653 6.193 1.00 109.64 C ATOM 791 CB THR D 428 1.679 24.016 5.680 1.00 107.37 C ATOM 792 OG1 THR D 428 0.839 25.079 6.154 1.00 104.87 O ATOM 793 CG2 THR D 428 1.742 24.020 4.130 1.00 99.22 C ATOM 794 C THR D 428 2.312 21.651 6.085 1.00 105.13 C ATOM 795 O THR D 428 2.346 20.805 5.193 1.00 82.97 O ATOM 796 N THR A 322 −31.414 15.182 38.883 1.00 64.74 N ATOM 797 CA THR A 322 −31.507 15.948 37.592 1.00 65.13 C ATOM 798 CB THR A 322 −32.053 17.388 37.762 1.00 63.14 C ATOM 799 OG1 THR A 322 −30.973 18.299 38.049 1.00 63.52 O ATOM 800 CG2 THR A 322 −33.157 17.474 38.815 1.00 75.66 C ATOM 801 C THR A 322 −30.200 16.078 36.763 1.00 63.22 C ATOM 802 O THR A 322 −30.272 16.554 35.618 1.00 55.31 O ATOM 803 N SER A 323 −29.035 15.703 37.321 1.00 56.23 N ATOM 804 CA SER A 323 −27.752 15.798 36.575 1.00 52.49 C ATOM 805 CB SER A 323 −26.487 15.611 37.422 1.00 45.96 C ATOM 806 OG SER A 323 −26.608 16.384 38.563 1.00 50.41 O ATOM 807 C SER A 323 −27.694 14.728 35.578 1.00 53.59 C ATOM 808 O SER A 323 −28.065 13.573 35.850 1.00 56.66 O ATOM 809 N LEU A 324 −27.160 15.115 34.433 1.00 51.12 N ATOM 810 CA LEU A 324 −26.909 14.197 33.353 1.00 50.45 C ATOM 811 CB LEU A 324 −27.661 14.631 32.096 1.00 42.68 C ATOM 812 CG LEU A 324 −29.186 14.555 32.201 1.00 57.69 C ATOM 813 CD1 LEU A 324 −29.809 14.881 30.853 1.00 57.87 C ATOM 814 CD2 LEU A 324 −29.685 13.178 32.656 1.00 63.57 C ATOM 815 C LEU A 324 −25.424 14.265 33.143 1.00 50.07 C ATOM 816 O LEU A 324 −24.888 15.335 32.857 1.00 47.17 O ATOM 817 N CYS A 325 −24.774 13.113 33.282 1.00 46.51 N ATOM 818 CA CYS A 325 −23.331 13.020 33.311 1.00 46.36 C ATOM 819 CB CYS A 325 −22.900 12.349 34.615 1.00 52.16 C ATOM 820 SG CYS A 325 −23.474 13.245 36.063 1.00 64.13 S ATOM 821 C CYS A 325 −22.794 12.234 32.133 1.00 43.72 C ATOM 822 O CYS A 325 −23.529 11.484 31.509 1.00 45.76 O ATOM 823 N CYS A 326 −21.496 12.393 31.866 1.00 40.87 N ATOM 824 CA CYS A 326 −20.781 11.694 30.820 1.00 47.88 C ATOM 825 CB CYS A 326 −19.357 12.248 30.796 1.00 49.28 C ATOM 826 SG CYS A 326 −17.955 11.249 30.203 1.00 50.74 S ATOM 827 C CYS A 326 −20.835 10.217 31.176 1.00 48.89 C ATOM 828 O CYS A 326 −20.460 9.853 32.275 1.00 56.30 O ATOM 829 N LYS A 327 −21.386 9.392 30.296 1.00 56.90 N ATOM 830 CA LYS A 327 −21.465 7.952 30.562 1.00 60.17 C ATOM 831 CB LYS A 327 −22.308 7.194 29.534 1.00 61.38 C ATOM 832 CG LYS A 327 −22.346 5.683 29.804 1.00 67.09 C ATOM 833 CD LYS A 327 −23.713 5.090 29.553 1.00 60.22 C ATOM 834 CE LYS A 327 −23.893 4.768 28.091 1.00 68.01 C ATOM 835 NZ LYS A 327 −25.351 4.786 27.794 1.00 67.37 N ATOM 836 C LYS A 327 −20.073 7.337 30.645 1.00 63.57 C ATOM 837 O LYS A 327 −19.748 6.715 31.670 1.00 63.43 O ATOM 838 N GLN A 328 −19.246 7.533 29.610 1.00 60.66 N ATOM 839 CA GLN A 328 −17.916 6.925 29.629 1.00 72.61 C ATOM 840 CB GLN A 328 −17.072 7.320 28.419 1.00 72.02 C ATOM 841 CG GLN A 328 −15.917 6.342 28.214 1.00 82.06 C ATOM 842 CD GLN A 328 −14.676 6.945 27.569 1.00 84.95 C ATOM 843 OE1 GLN A 328 −14.714 7.448 26.442 1.00 94.25 O ATOM 844 NE2 GLN A 328 −13.553 6.862 28.274 1.00 86.62 N ATOM 845 C GLN A 328 −17.151 7.187 30.948 1.00 74.82 C ATOM 846 O GLN A 328 −16.449 6.308 31.437 1.00 78.05 O ATOM 847 N CYS A 329 −17.308 8.373 31.536 1.00 69.12 N ATOM 848 CA CYS A 329 −16.484 8.764 32.691 1.00 62.17 C ATOM 849 CB CYS A 329 −15.686 10.045 32.373 1.00 67.93 C ATOM 850 SG CYS A 329 −16.526 11.591 31.831 1.00 56.12 S ATOM 851 C CYS A 329 −17.206 8.903 34.026 1.00 61.90 C ATOM 852 O CYS A 329 −16.589 8.781 35.073 1.00 54.67 O ATOM 853 N GLN A 330 −18.506 9.185 33.996 1.00 64.20 N ATOM 854 CA GLN A 330 −19.273 9.522 35.209 1.00 59.62 C ATOM 855 CB GLN A 330 −19.587 8.275 36.037 1.00 70.87 C ATOM 856 CG GLN A 330 −20.882 7.568 35.633 1.00 80.09 C ATOM 857 CD GLN A 330 −21.102 6.259 36.389 1.00 87.88 C ATOM 858 OE1 GLN A 330 −21.255 6.248 37.619 1.00 90.17 O ATOM 859 NE2 GLN A 330 −21.128 5.148 35.655 1.00 86.39 N ATOM 860 C GLN A 330 −18.643 10.589 36.087 1.00 54.02 C ATOM 861 O GLN A 330 −19.181 10.905 37.135 1.00 60.58 O ATOM 862 N GLU A 331 −17.525 11.170 35.680 1.00 54.07 N ATOM 863 CA GLU A 331 −16.919 12.212 36.536 1.00 73.03 C ATOM 864 CB GLU A 331 −15.414 12.367 36.265 1.00 72.64 C ATOM 865 CG GLU A 331 −14.531 11.323 36.943 1.00 79.25 C ATOM 866 CD GLU A 331 −14.334 11.514 38.459 1.00 80.32 C ATOM 867 OE1 GLU A 331 −14.517 10.511 39.196 1.00 80.47 O ATOM 868 OE2 GLU A 331 −13.967 12.636 38.912 1.00 73.65 O ATOM 869 C GLU A 331 −17.635 13.571 36.405 1.00 72.63 C ATOM 870 O GLU A 331 −17.721 14.335 37.361 1.00 79.20 O ATOM 871 N THR A 332 −18.205 13.809 35.229 1.00 62.77 N ATOM 872 CA THR A 332 −18.537 15.143 34.770 1.00 62.82 C ATOM 873 CB THR A 332 −17.703 15.424 33.518 1.00 66.12 C ATOM 874 OG1 THR A 332 −16.445 14.752 33.667 1.00 68.14 O ATOM 875 CG2 THR A 332 −17.442 16.871 33.408 1.00 60.32 C ATOM 876 C THR A 332 −20.024 15.345 34.453 1.00 54.02 C ATOM 877 O THR A 332 −20.628 14.551 33.709 1.00 49.63 O ATOM 878 N GLU A 333 −20.613 16.381 35.043 1.00 44.93 N ATOM 879 CA GLU A 333 −21.970 16.796 34.662 1.00 45.79 C ATOM 880 CB GLU A 333 −22.646 17.659 35.710 1.00 41.88 C ATOM 881 CG GLU A 333 −24.107 18.037 35.307 1.00 41.57 C ATOM 882 CD GLU A 333 −24.785 18.918 36.342 1.00 44.48 C ATOM 883 OE1 GLU A 333 −25.213 18.381 37.397 1.00 49.79 O ATOM 884 OE2 GLU A 333 −24.863 20.159 36.132 1.00 43.44 O ATOM 885 C GLU A 333 −21.901 17.556 33.344 1.00 44.03 C ATOM 886 O GLU A 333 −21.093 18.454 33.231 1.00 47.11 O ATOM 887 N ILE A 334 −22.744 17.169 32.373 1.00 39.63 N ATOM 888 CA ILE A 334 −22.823 17.787 31.043 1.00 42.29 C ATOM 889 CB ILE A 334 −22.929 16.704 29.933 1.00 42.43 C ATOM 890 CG1 ILE A 334 −21.714 15.715 29.954 1.00 46.99 C ATOM 891 CD1 ILE A 334 −20.329 16.329 29.651 1.00 43.86 C ATOM 892 CG2 ILE A 334 −23.054 17.334 28.587 1.00 42.58 C ATOM 893 C ILE A 334 −23.988 18.785 30.910 1.00 41.09 C ATOM 894 O ILE A 334 −23.860 19.810 30.235 1.00 41.01 O ATOM 895 N THR A 335 −25.134 18.472 31.517 1.00 40.66 N ATOM 896 CA THR A 335 −26.299 19.366 31.489 1.00 37.57 C ATOM 897 CB THR A 335 −27.016 19.396 30.127 1.00 38.85 C ATOM 898 OG1 THR A 335 −28.079 20.346 30.218 1.00 42.46 O ATOM 899 CG2 THR A 335 −27.640 18.028 29.760 1.00 41.75 C ATOM 900 C THR A 335 −27.239 18.935 32.601 1.00 43.86 C ATOM 901 O THR A 335 −26.916 17.975 33.317 1.00 44.98 O ATOM 902 N THR A 336 −28.383 19.613 32.763 1.00 45.29 N ATOM 903 CA THR A 336 −29.393 19.185 33.748 1.00 45.65 C ATOM 904 CB THR A 336 −29.512 20.143 34.967 1.00 47.73 C ATOM 905 OG1 THR A 336 −30.147 21.349 34.565 1.00 45.83 O ATOM 906 CG2 THR A 336 −28.161 20.478 35.589 1.00 51.69 C ATOM 907 C THR A 336 −30.774 19.040 33.071 1.00 47.57 C ATOM 908 O THR A 336 −30.995 19.556 31.984 1.00 44.30 O ATOM 909 N LYS A 337 −31.704 18.355 33.732 1.00 47.45 N ATOM 910 CA LYS A 337 −33.047 18.167 33.189 1.00 50.85 C ATOM 911 CB LYS A 337 −33.876 17.226 34.077 1.00 55.34 C ATOM 912 CG LYS A 337 −33.520 15.757 33.878 1.00 65.18 C ATOM 913 CD LYS A 337 −34.263 14.859 34.850 1.00 73.47 C ATOM 914 CE LYS A 337 −34.269 13.447 34.309 1.00 81.28 C ATOM 915 NZ LYS A 337 −34.549 12.492 35.413 1.00 88.29 N ATOM 916 C LYS A 337 −33.772 19.490 33.005 1.00 47.39 C ATOM 917 O LYS A 337 −34.641 19.597 32.142 1.00 46.09 O ATOM 918 N ASN A 338 −33.400 20.491 33.804 1.00 44.39 N ATOM 919 CA ASN A 338 −33.970 21.838 33.722 1.00 41.29 C ATOM 920 CB ASN A 338 −33.481 22.681 34.896 1.00 44.93 C ATOM 921 CG ASN A 338 −33.830 22.059 36.224 1.00 52.51 C ATOM 922 OD1 ASN A 338 −33.006 21.427 36.867 1.00 57.16 O ATOM 923 ND2 ASN A 338 −35.053 22.209 36.621 1.00 51.44 N ATOM 924 C ASN A 338 −33.678 22.560 32.401 1.00 41.09 C ATOM 925 O ASN A 338 −34.430 23.457 31.997 1.00 40.58 O ATOM 926 N GLU A 339 −32.627 22.141 31.703 1.00 38.41 N ATOM 927 CA GLU A 339 −32.253 22.798 30.431 1.00 38.84 C ATOM 928 CB GLU A 339 −30.716 22.853 30.297 1.00 34.72 C ATOM 929 CG GLU A 339 −30.014 23.462 31.522 1.00 34.35 C ATOM 930 CD GLU A 339 −30.507 24.918 31.772 1.00 43.96 C ATOM 931 OE1 GLU A 339 −30.537 25.730 30.817 1.00 39.26 O ATOM 932 OE2 GLU A 339 −30.971 25.257 32.888 1.00 46.21 O ATOM 933 C GLU A 339 −32.892 22.172 29.186 1.00 40.42 C ATOM 934 O GLU A 339 −32.756 22.707 28.084 1.00 47.50 O ATOM 935 N ILE A 340 −33.596 21.047 29.353 1.00 44.38 N ATOM 936 CA ILE A 340 −34.286 20.369 28.220 1.00 39.11 C ATOM 937 CB ILE A 340 −34.846 18.973 28.612 1.00 40.87 C ATOM 938 CG1 ILE A 340 −33.715 18.109 29.195 1.00 43.08 C ATOM 939 CD1 ILE A 340 −34.170 16.809 29.853 1.00 47.03 C ATOM 940 CG2 ILE A 340 −35.482 18.281 27.387 1.00 44.41 C ATOM 941 C ILE A 340 −35.413 21.246 27.644 1.00 41.35 C ATOM 942 O ILE A 340 −36.215 21.795 28.374 1.00 39.08 O ATOM 943 N PHE A 341 −35.428 21.424 26.327 1.00 37.10 N ATOM 944 CA PHE A 341 −36.558 22.049 25.690 1.00 37.83 C ATOM 945 CB PHE A 341 −36.284 23.502 25.351 1.00 33.12 C ATOM 946 CG PHE A 341 −35.296 23.704 24.227 1.00 37.76 C ATOM 947 CD1 PHE A 341 −35.732 24.118 22.959 1.00 38.80 C ATOM 948 CE1 PHE A 341 −34.824 24.334 21.940 1.00 32.41 C ATOM 949 CZ PHE A 341 −33.457 24.152 22.179 1.00 30.75 C ATOM 950 CE2 PHE A 341 −33.009 23.733 23.415 1.00 30.54 C ATOM 951 CD2 PHE A 341 −33.922 23.534 24.436 1.00 35.39 C ATOM 952 C PHE A 341 −36.839 21.260 24.435 1.00 38.22 C ATOM 953 O PHE A 341 −36.107 20.355 24.067 1.00 42.66 O ATOM 954 N SER A 342 −37.862 21.634 23.704 1.00 46.41 N ATOM 955 CA SER A 342 −38.199 20.918 22.485 1.00 51.38 C ATOM 956 CB SER A 342 −39.610 20.386 22.556 1.00 57.79 C ATOM 957 OG SER A 342 −39.659 19.279 23.409 1.00 75.28 O ATOM 958 C SER A 342 −38.084 21.742 21.241 1.00 48.74 C ATOM 959 O SER A 342 −38.958 22.464 20.908 1.00 48.80 O ATOM 960 N LEU A 343 −37.003 21.610 20.528 1.00 47.75 N ATOM 961 CA LEU A 343 −36.826 22.435 19.322 1.00 50.19 C ATOM 962 CB LEU A 343 −35.459 22.162 18.661 1.00 45.08 C ATOM 963 CG LEU A 343 −34.648 23.130 17.750 1.00 49.41 C ATOM 964 CD1 LEU A 343 −34.709 22.910 16.236 1.00 49.16 C ATOM 965 CD2 LEU A 343 −34.833 24.614 18.066 1.00 45.09 C ATOM 966 C LEU A 343 −37.944 22.195 18.315 1.00 52.22 C ATOM 967 O LEU A 343 −38.415 23.113 17.637 1.00 56.71 O ATOM 968 N SER A 344 −38.345 20.948 18.185 1.00 58.08 N ATOM 969 CA SER A 344 −39.508 20.641 17.365 1.00 69.47 C ATOM 970 CB SER A 344 −39.114 20.197 15.945 1.00 67.92 C ATOM 971 OG SER A 344 −39.927 19.108 15.518 1.00 69.32 O ATOM 972 C SER A 344 −40.374 19.604 18.055 1.00 66.17 C ATOM 973 O SER A 344 −39.871 18.571 18.537 1.00 70.56 O ATOM 974 N ALA A 345 −41.674 19.896 18.082 1.00 62.07 N ATOM 975 CA ALA A 345 −42.677 18.988 18.619 1.00 63.73 C ATOM 976 CB ALA A 345 −43.948 19.773 18.968 1.00 63.20 C ATOM 977 C ALA A 345 −42.964 17.792 17.656 1.00 67.80 C ATOM 978 O ALA A 345 −43.657 16.856 18.045 1.00 62.78 O ATOM 979 N ALA A 345 −42.400 17.824 16.432 1.00 62.89 N` ATOM 980 CA CYS A 346 −42.583 16.769 15.392 1.00 69.62 C ATOM 981 CB CYS A 346 −41.932 15.434 15.800 1.00 68.65 C ATOM 982 SG CYS A 346 −40.189 15.554 16.252 1.00 84.42 S ATOM 983 C CYS A 346 −44.061 16.515 15.085 1.00 60.24 C ATOM 984 O CYS A 346 −44.485 15.370 14.971 1.00 50.99 O ATOM 985 N GLY A 347 −44.832 17.590 15.009 1.00 49.48 N ATOM 986 CA GLY A 347 −46.210 17.515 14.650 1.00 52.95 C ATOM 987 C GLY A 347 −46.246 17.478 13.151 1.00 53.01 C ATOM 988 O GLY A 347 −45.200 17.467 12.518 1.00 61.62 O ATOM 989 N PRO A 348 −47.454 17.476 12.578 1.00 52.91 N ATOM 990 CA PRO A 348 −47.645 17.442 11.124 1.00 54.65 C ATOM 991 CB PRO A 348 −49.172 17.268 10.945 1.00 52.63 C ATOM 992 CG PRO A 348 −49.778 17.349 12.304 1.00 47.70 C ATOM 993 CD PRO A 348 −48.699 17.266 13.339 1.00 50.70 C ATOM 994 C PRO A 348 −47.151 18.697 10.431 1.00 54.83 C ATOM 995 O PRO A 348 −46.631 18.632 9.308 1.00 54.59 O ATOM 996 N MET A 349 −47.310 19.842 11.079 1.00 61.26 N ATOM 997 CA MET A 349 −46.863 21.093 10.456 1.00 68.28 C ATOM 998 CB MET A 349 −47.793 22.275 10.819 1.00 74.12 C ATOM 999 CG MET A 349 −48.982 22.495 9.859 1.00 79.45 C ATOM 1000 SD MET A 349 −48.717 21.930 8.144 1.00 87.13 S ATOM 1001 CE MET A 349 −49.873 22.932 7.193 1.00 90.16 C ATOM 1002 C MET A 349 −45.364 21.388 10.737 1.00 72.94 C ATOM 1003 O MET A 349 −44.918 22.530 10.658 1.00 73.72 O ATOM 1004 N ALA A 350 −44.589 20.353 11.056 1.00 73.90 N ATOM 1005 CA ALA A 350 −43.156 20.535 11.320 1.00 84.99 C ATOM 1006 CB ALA A 350 −42.747 19.851 12.626 1.00 76.62 C ATOM 1007 C ALA A 350 −42.316 20.037 10.137 1.00 80.23 C ATOM 1008 O ALA A 350 −42.188 18.832 9.918 1.00 79.05 O ATOM 1009 N ALA A 351 −41.784 20.968 9.346 1.00 88.56 N ATOM 1010 CA ALA A 351 −40.859 20.603 8.256 1.00 101.15 C ATOM 1011 CB ALA A 351 −41.061 21.481 7.017 1.00 94.52 C ATOM 1012 C ALA A 351 −39.430 20.701 8.778 1.00 91.22 C ATOM 1013 O ALA A 351 −39.234 21.038 9.946 1.00 86.64 O ATOM 1014 N TYR A 358 −32.217 14.583 14.906 1.00 76.26 N ATOM 1015 CA TYR A 358 −32.697 13.381 15.570 1.00 87.03 C ATOM 1016 CB TYR A 358 −31.523 12.517 16.024 1.00 87.26 C ATOM 1017 CG TYR A 358 −30.790 11.826 14.900 1.00 90.83 C ATOM 1018 CD1 TYR A 358 −29.710 10.976 15.177 1.00 96.91 C ATOM 1019 CE1 TYR A 358 −29.016 10.334 14.158 1.00 94.54 C ATOM 1020 CZ TYR A 358 −29.406 10.527 12.840 1.00 96.88 C ATOM 1021 OH TYR A 358 −28.712 9.878 11.838 1.00 93.98 O ATOM 1022 CE2 TYR A 358 −30.485 11.356 12.535 1.00 98.54 C ATOM 1023 CD2 TYR A 358 −31.175 11.994 13.561 1.00 94.83 C ATOM 1024 C TYR A 358 −33.577 13.740 16.749 1.00 83.80 C ATOM 1025 O TYR A 358 −33.576 14.892 17.206 1.00 74.42 O ATOM 1026 N VAL A 359 −34.294 12.742 17.264 1.00 90.76 N ATOM 1027 CA VAL A 359 −35.467 13.014 18.097 1.00 94.80 C ATOM 1028 CB VAL A 359 −36.788 12.745 17.316 1.00 99.96 C ATOM 1029 CG1 VAL A 359 −37.433 14.069 16.928 1.00 98.31 C ATOM 1030 CG2 VAL A 359 −36.571 11.853 16.085 1.00 85.58 C ATOM 1031 C VAL A 359 −35.489 12.407 19.516 1.00 102.77 C ATOM 1032 O VAL A 359 −35.563 13.146 20.515 1.00 86.81 O ATOM 1033 N HIS A 360 −35.462 11.072 19.592 1.00 112.12 N ATOM 1034 CA HIS A 360 −35.299 10.328 20.854 1.00 104.65 C ATOM 1035 CB HIS A 360 −36.416 9.307 21.072 1.00 116.16 C ATOM 1036 CG HIS A 360 −36.922 8.681 19.796 1.00 133.85 C ATOM 1037 ND1 HIS A 360 −38.083 9.056 19.216 1.00 138.07 N ATOM 1038 CE1 HIS A 360 −38.270 8.343 18.088 1.00 139.22 C ATOM 1039 NE2 HIS A 360 −37.220 7.513 17.939 1.00 138.53 N ATOM 1040 CD2 HIS A 360 −36.369 7.698 18.894 1.00 136.91 C ATOM 1041 C HIS A 360 −33.943 9.671 20.861 1.00 104.71 C ATOM 1042 O HIS A 360 −33.644 8.788 21.868 1.00 87.11 O ATOM 1043 N GLU A 361 −33.112 10.102 19.915 1.00 90.48 N ATOM 1044 CA GLU A 361 −31.701 9.778 19.922 1.00 83.91 C ATOM 1045 CB GLU A 361 −31.206 9.488 18.506 1.00 84.72 C ATOM 1046 CG GLU A 361 −31.883 8.313 17.817 1.00 102.02 C ATOM 1047 CD GLU A 361 −31.828 8.436 16.304 1.00 103.03 C ATOM 1048 OE1 GLU A 361 −30.769 8.103 15.730 1.00 99.43 O ATOM 1049 OE2 GLU A 361 −32.839 8.872 15.698 1.00 100.80 O ATOM 1050 C GLU A 361 −30.948 10.977 20.503 1.00 76.97 C ATOM 1051 O GLU A 361 −29.887 10.806 21.106 1.00 65.34 O ATOM 1052 N THR A 362 −31.529 12.171 20.320 1.00 72.35 N ATOM 1053 CA THR A 362 −30.872 13.462 20.588 1.00 67.50 C ATOM 1054 CB THR A 362 −30.474 14.191 19.289 1.00 71.14 C ATOM 1055 OG1 THR A 362 −29.448 13.445 18.643 1.00 66.76 O ATOM 1056 CG2 THR A 362 −29.921 15.590 19.567 1.00 64.02 C ATOM 1057 C THR A 362 −31.719 14.380 21.465 1.00 62.30 C ATOM 1058 O THR A 362 −32.871 14.711 21.151 1.00 62.12 O ATOM 1059 N LEU A 363 −31.121 14.761 22.580 1.00 52.70 N ATOM 1060 CA LEU A 363 −31.707 15.666 23.529 1.00 48.22 C ATOM 1061 CB LEU A 363 −31.118 15.272 24.855 1.00 52.62 C ATOM 1062 CG LEU A 363 −31.753 15.524 26.190 1.00 51.68 C ATOM 1063 CD1 LEU A 363 −33.179 15.013 26.229 1.00 54.33 C ATOM 1064 CD2 LEU A 363 −30.892 14.724 27.139 1.00 55.72 C ATOM 1065 C LEU A 363 −31.230 17.063 23.138 1.00 47.89 C ATOM 1066 O LEU A 363 −30.056 17.221 22.792 1.00 52.97 O ATOM 1067 N THR A 364 −32.132 18.044 23.087 1.00 45.95 N ATOM 1068 CA THR A 364 −31.773 19.454 22.795 1.00 40.45 C ATOM 1069 CB THR A 364 −32.771 20.135 21.816 1.00 40.59 C ATOM 1070 OG1 THR A 364 −34.119 19.925 22.285 1.00 40.37 O ATOM 1071 CG2 THR A 364 −32.577 19.587 20.362 1.00 37.83 C ATOM 1072 C THR A 364 −31.816 20.214 24.136 1.00 40.76 C ATOM 1073 O THR A 364 −32.822 20.139 24.829 1.00 33.60 O ATOM 1074 N VAL A 365 −30.717 20.877 24.536 1.00 36.90 N ATOM 1075 CA VAL A 365 −30.706 21.622 25.821 1.00 33.17 C ATOM 1076 CB VAL A 365 −29.881 20.935 26.949 1.00 34.05 C ATOM 1077 CG1 VAL A 365 −30.501 19.597 27.359 1.00 34.55 C ATOM 1078 CG2 VAL A 365 −28.383 20.790 26.590 1.00 30.19 C ATOM 1079 C VAL A 365 −30.188 23.022 25.566 1.00 33.35 C ATOM 1080 O VAL A 365 −29.449 23.241 24.621 1.00 37.80 O ATOM 1081 N TYR A 366 −30.642 23.985 26.354 1.00 35.60 N ATOM 1082 CA TYR A 366 −30.252 25.373 26.171 1.00 33.19 C ATOM 1083 CB TYR A 366 −31.205 26.240 27.000 1.00 37.48 C ATOM 1084 CG TYR A 366 −32.550 26.504 26.367 1.00 33.76 C ATOM 1085 CD1 TYR A 366 −32.624 27.001 25.079 1.00 37.46 C ATOM 1086 CE1 TYR A 366 −33.846 27.271 24.482 1.00 40.20 C ATOM 1087 CZ TYR A 366 −35.029 27.039 25.197 1.00 40.18 C ATOM 1088 OH TYR A 366 −36.237 27.315 24.589 1.00 38.19 O ATOM 1089 CE2 TYR A 366 −34.980 26.532 26.490 1.00 37.59 C ATOM 1090 CD2 TYR A 366 −33.735 26.270 27.069 1.00 34.30 C ATOM 1091 C TYR A 366 −28.844 25.602 26.665 1.00 30.48 C ATOM 1092 O TYR A 366 −28.112 26.451 26.168 1.00 34.80 O ATOM 1093 N LYS A 367 −28.450 24.857 27.693 1.00 34.30 N ATOM 1094 CA LYS A 367 −27.126 25.031 28.291 1.00 34.09 C ATOM 1095 CB LYS A 367 −27.236 25.866 29.590 1.00 35.39 C ATOM 1096 CG LYS A 367 −27.661 27.326 29.403 1.00 42.37 C ATOM 1097 CD LYS A 367 −26.500 28.160 28.829 1.00 37.61 C ATOM 1098 CE LYS A 367 −26.588 29.642 29.109 1.00 40.08 C ATOM 1099 NZ LYS A 367 −25.262 30.243 28.743 1.00 44.44 N ATOM 1100 C LYS A 367 −26.484 23.667 28.621 1.00 33.71 C ATOM 1101 O LYS A 367 −27.164 22.678 28.991 1.00 29.89 O ATOM 1102 N ALA A 368 −25.169 23.671 28.629 1.00 32.16 N ATOM 1103 CA ALA A 368 −24.383 22.504 28.875 1.00 36.79 C ATOM 1104 CB ALA A 368 −24.205 21.746 27.569 1.00 38.81 C ATOM 1105 C ALA A 368 −23.013 22.918 29.469 1.00 39.58 C ATOM 1106 O ALA A 368 −22.578 24.053 29.340 1.00 35.20 O ATOM 1107 N SER A 369 −22.341 21.994 30.139 1.00 37.78 N ATOM 1108 CA SER A 369 −21.075 22.333 30.775 1.00 39.32 C ATOM 1109 CB SER A 369 −21.323 22.454 32.265 1.00 38.18 C ATOM 1110 OG SER A 369 −21.894 21.240 32.747 1.00 42.15 O ATOM 1111 C SER A 369 −20.047 21.239 30.531 1.00 40.37 C ATOM 1112 O SER A 369 −20.408 20.075 30.272 1.00 37.13 O ATOM 1113 N ASN A 370 −18.768 21.610 30.574 1.00 42.00 N ATOM 1114 CA ASN A 370 −17.668 20.630 30.562 1.00 44.71 C ATOM 1115 CB ASN A 370 −17.804 19.3634 31.727 1.00 42.34 C ATOM 1116 CH ASN A 370 −17.826 20.336 33.063 1.00 46.61 C ATOM 1117 OD1 ASN A 370 −18.656 20.068 33.937 1.00 48.41 O ATOM 1118 ND2 ASN A 370 −16.939 21.285 33.207 1.00 45.13 N ATOM 1119 C ASN A 370 −17.469 19.878 29.251 1.00 47.30 C ATOM 1120 O ASN A 370 −17.003 18.723 29.250 1.00 46.85 O ATOM 1121 N LEU A 371 −17.797 20.557 28.159 1.00 44.74 N ATOM 1122 CA LEU A 371 −17.615 20.060 26.789 1.00 42.12 C ATOM 1123 CB LEU A 371 −18.932 20.189 25.977 1.00 33.71 C ATOM 1124 CG LEU A 371 −20.047 19.206 26.391 1.00 38.67 C ATOM 1125 CD1 LEU A 371 −21.387 19.519 25.736 1.00 39.53 C ATOM 1126 CD2 LEU A 371 −19.676 17.722 26.139 1.00 32.94 C ATOM 1127 C LEU A 371 −16.556 20.924 26.165 1.00 44.99 C ATOM 1128 O LEU A 371 −16.569 22.141 26.359 1.00 49.20 O ATOM 1129 N ASN A 372 −15.631 20.297 25.438 1.00 45.74 N ATOM 1130 CA ASN A 372 −14.690 21.003 24.575 1.00 49.09 C ATOM 1131 CB ASN A 372 −13.292 20.364 24.625 1.00 50.76 C ATOM 1132 CG ASN A 372 −12.584 20.640 25.923 1.00 52.77 C ATOM 1133 OD1 ASN A 372 −12.783 21.694 26.522 1.00 57.63 O ATOM 1134 ND2 ASN A 372 −11.768 19.695 26.379 1.00 51.24 N ATOM 1135 C ASN A 372 −15.203 20.995 23.150 1.00 45.87 C ATOM 1136 O ASN A 372 −15.686 19.971 22.692 1.00 38.93 O ATOM 1137 N LEU A 373 −15.089 22.135 22.466 1.00 44.12 N ATOM 1138 CA LEU A 373 −15.444 22.237 21.055 1.00 43.92 C ATOM 1139 CB LEU A 373 −15.850 23.673 20.678 1.00 38.68 C ATOM 1140 CG LEU A 373 −16.992 24.295 21.473 1.00 45.58 C ATOM 1141 CD1 LEU A 373 −17.197 25.765 21.041 1.00 44.85 C ATOM 1142 CD2 LEU A 373 −18.262 23.466 21.277 1.00 39.83 C ATOM 1143 C LEU A 373 −14.284 21.798 20.194 1.00 49.50 C ATOM 1144 O LEU A 373 −13.115 22.191 20.420 1.00 52.34 O ATOM 1145 N ILE A 374 −14.623 21.025 19.170 1.00 44.70 N ATOM 1146 CA ILE A 374 −13.621 20.370 18.335 1.00 41.52 C ATOM 1147 CB ILE A 374 −13.760 18.825 18.416 1.00 43.27 C ATOM 1148 CG1 ILE A 374 −13.568 18.317 19.859 1.00 44.55 C ATOM 1149 CD1 ILE A 374 −12.189 18.570 20.449 1.00 43.82 C ATOM 1150 CG2 ILE A 374 −12.768 18.145 17.483 1.00 43.53 C ATOM 1151 C ILE A 374 −13.922 20.799 16.923 1.00 43.89 C ATOM 1152 O ILE A 374 −15.040 20.573 16.427 1.00 48.03 O ATOM 1153 N GLY A 375 −12.935 21.405 16.272 1.00 40.77 N ATOM 1154 CA GLY A 375 −13.061 21.842 14.868 1.00 45.94 C ATOM 1155 C GLY A 375 −13.937 23.097 14.732 1.00 54.11 C ATOM 1156 O GLY A 375 −14.292 23.684 15.730 1.00 45.38 O ATOM 1157 N ARG A 376 −14.255 23.512 13.501 1.00 58.28 N ATOM 1158 CA ARG A 376 −15.126 24.671 13.250 1.00 57.12 C ATOM 1159 CB ARG A 376 −14.607 25.598 12.130 1.00 53.14 C ATOM 1160 CG ARG A 376 −13.791 25.030 10.991 1.00 59.61 C ATOM 1161 CD ARG A 376 −12.290 25.201 11.188 1.00 61.21 C ATOM 1162 NE ARG A 376 −11.825 26.542 11.512 1.00 66.84 N ATOM 1163 CZ ARG A 376 −11.049 27.315 10.744 1.00 74.19 C ATOM 1164 NH1 ARG A 376 −10.641 26.926 9.531 1.00 54.90 N ATOM 1165 NH2 ARG A 376 −10.964 28.522 11.202 1.00 75.02 N ATOM 1166 C ARG A 376 −16.594 24.274 12.981 1.00 55.95 C ATOM 1167 O ARG A 376 −16.894 23.073 12.804 1.00 49.02 O ATOM 1168 N PRO A 377 −17.515 25.273 12.989 1.00 48.67 N ATOM 1169 CA PRO A 377 −18.934 24.983 12.714 1.00 45.57 C ATOM 1170 CB PRO A 377 −19.653 26.311 13.043 1.00 50.52 C ATOM 1171 CG PRO A 377 −18.563 27.366 13.026 1.00 52.89 C ATOM 1172 CD PRO A 377 −17.327 26.649 13.517 1.00 54.19 C ATOM 1173 C PRO A 377 −19.187 24.564 11.270 1.00 44.11 C ATOM 1174 O PRO A 377 −18.568 25.073 10.357 1.00 46.74 O ATOM 1175 N SER A 378 −20.097 23.628 11.072 1.00 44.73 N ATOM 1176 CA SER A 378 −20.440 23.246 9.740 1.00 52.10 C ATOM 1177 CB SER A 378 −19.958 21.818 9.473 1.00 49.37 C ATOM 1178 OG SER A 378 −20.572 21.366 8.284 1.00 54.59 O ATOM 1179 C SER A 378 −21.939 23.360 9.449 1.00 53.64 C ATOM 1180 O SER A 378 −22.773 22.952 10.251 1.00 62.33 O ATOM 1181 N THR A 379 −22.226 23.886 8.262 1.00 61.19 N ATOM 1182 CA THR A 379 −23.557 24.110 7.730 1.00 64.57 C ATOM 1183 CB THR A 379 −23.642 25.511 7.088 1.00 67.63 C ATOM 1184 OG1 THR A 379 −22.486 25.734 6.262 1.00 69.24 O ATOM 1185 CG2 THR A 379 −23.707 26.625 8.156 1.00 65.63 C ATOM 1186 C THR A 379 −23.858 23.078 6.650 1.00 69.89 C ATOM 1187 O THR A 379 −24.837 23.225 5.930 1.00 70.61 O ATOM 1188 N VAL A 380 −23.014 22.036 6.546 1.00 71.89 N ATOM 1189 CA VAL A 380 −23.190 20.907 5.594 1.00 60.25 C ATOM 1190 CB VAL A 380 −21.819 20.342 5.070 1.00 66.55 C ATOM 1191 CG1 VAL A 380 −22.045 19.135 4.150 1.00 65.20 C ATOM 1192 CG2 VAL A 380 −20.952 21.416 4.385 1.00 55.02 C ATOM 1193 C VAL A 380 −23.925 19.744 6.278 1.00 58.18 C ATOM 1194 O VAL A 380 −23.459 19.211 7.268 1.00 55.18 O ATOM 1195 N HIS A 381 −25.072 19.343 5.755 1.00 56.88 N ATOM 1196 CA HIS A 381 −25.825 18.250 6.358 1.00 66.60 C ATOM 1197 CB HIS A 381 −25.111 16.902 6.145 1.00 76.83 C ATOM 1198 CG HIS A 381 −25.088 16.450 4.695 1.00 94.88 C ATOM 1199 ND1 HIS A 381 −26.201 16.461 3.905 1.00 102.32 N ATOM 1200 CE1 HIS A 381 −25.877 16.019 2.672 1.00 103.55 C ATOM 1201 NE2 HIS A 381 −24.556 15.724 2.668 1.00 102.79 N ATOM 1202 CD2 HIS A 381 −24.044 15.974 3.899 1.00 91.39 C ATOM 1203 C HIS A 381 −26.169 18.436 7.811 1.00 66.26 C ATOM 1204 O HIS A 381 −26.255 17.474 8.557 1.00 73.24 O ATOM 1205 N SER A 382 −26.420 19.665 8.236 1.00 59.39 N ATOM 1206 CA SER A 382 −26.861 19.880 9.604 1.00 56.18 C ATOM 1207 CB SER A 382 −26.969 21.374 9.925 1.00 53.01 C ATOM 1208 OG SER A 382 −27.450 21.511 11.270 1.00 52.72 O ATOM 1209 C SER A 382 −28.199 19.187 9.902 1.00 52.61 C ATOM 1210 O SER A 382 −29.104 19.225 9.108 1.00 50.12 O ATOM 1211 N TRP A 383 −28.326 18.588 11.074 1.00 54.29 N ATOM 1212 CA TRP A 383 −29.575 17.934 11.469 1.00 54.64 C ATOM 1213 CB TRP A 383 −29.327 17.010 12.665 1.00 62.52 C ATOM 1214 CG TRP A 383 −28.406 15.848 12.350 1.00 68.50 C ATOM 1215 CD1 TRP A 383 −28.012 15.398 11.091 1.00 65.80 C ATOM 1216 NE1 TRP A 383 −27.197 14.309 11.200 1.00 71.15 N ATOM 1217 CE2 TRP A 383 −27.018 13.962 12.487 1.00 67.46 C ATOM 1218 CD2 TRP A 383 −27.783 14.912 13.296 1.00 66.88 C ATOM 1219 CE3 TRP A 383 −27.781 14.772 14.670 1.00 69.07 C ATOM 1220 CZ3 TRP A 383 −27.042 13.726 15.231 1.00 65.27 C ATOM 1221 CH2 TRP A 383 −26.311 12.829 14.441 1.00 66.51 C ATOM 1222 CZ2 TRP A 383 −26.284 12.929 13.055 1.00 66.29 C ATOM 1223 C TRP A 383 −30.709 18.846 11.810 1.00 56.65 C ATOM 1224 O TRP A 383 −31.830 18.381 12.035 1.00 53.65 O ATOM 1225 N PHE A 384 −30.433 20.149 11.865 1.00 55.34 N ATOM 1226 CA PHE A 384 −31.373 21.135 12.380 1.00 49.78 C ATOM 1227 CB PHE A 384 −31.026 21.526 13.828 1.00 46.49 C ATOM 1228 CG PHE A 384 −31.443 20.499 14.861 1.00 42.91 C ATOM 1229 CD1 PHE A 384 −32.785 20.294 15.145 1.00 50.84 C ATOM 1230 CE1 PHE A 384 −33.191 19.359 16.077 1.00 48.30 C ATOM 1231 CZ PHE A 384 −32.245 18.596 16.740 1.00 41.55 C ATOM 1232 CE2 PHE A 384 −30.905 18.798 16.475 1.00 44.68 C ATOM 1233 CD2 PHE A 384 −30.511 19.755 15.546 1.00 46.48 C ATOM 1234 C PHE A 384 −31.190 22.321 11.465 1.00 55.27 C ATOM 1235 O PHE A 384 −30.302 23.158 11.712 1.00 50.89 O ATOM 1236 N PRO A 385 −32.015 22.393 10.395 1.00 56.35 N ATOM 1237 CA PRO A 385 −31.851 23.393 9.336 1.00 59.39 C ATOM 1238 CB PRO A 385 −33.073 23.172 8.433 1.00 60.57 C ATOM 1239 CG PRO A 385 −33.552 21.803 8.753 1.00 62.49 C ATOM 1240 CD PRO A 385 −33.212 21.556 10.188 1.00 57.37 C ATOM 1241 C PRO A 385 −31.888 24.773 9.942 1.00 58.77 C ATOM 1242 O PRO A 385 −32.671 25.014 10.856 1.00 55.86 O ATOM 1243 N GLY A 386 −31.026 25.658 9.465 1.00 52.17 N ATOM 1244 CA GLY A 386 −30.873 26.933 10.104 1.00 54.56 C ATOM 1245 C GLY A 386 −29.711 27.039 11.067 1.00 54.18 C ATOM 1246 O GLY A 386 −29.319 28.151 11.452 1.00 56.11 O ATOM 1247 N TYR A 387 −29.150 25.902 11.456 1.00 50.58 N ATOM 1248 CA TYR A 387 −28.034 25.885 12.440 1.00 51.00 C ATOM 1249 CB TYR A 387 −28.468 25.226 13.754 1.00 44.20 C ATOM 1250 CG TYR A 387 −29.576 25.940 14.524 1.00 42.14 C ATOM 1251 CD1 TYR A 387 −29.261 26.824 15.539 1.00 44.50 C ATOM 1252 CE1 TYR A 387 −30.236 27.480 16.268 1.00 41.88 C ATOM 1253 CZ TYR A 387 −31.547 27.262 15.992 1.00 39.72 C ATOM 1254 OH TYR A 387 −32.450 27.944 16.743 1.00 42.41 O ATOM 1255 CE2 TYR A 387 −31.931 26.381 14.987 1.00 45.31 C ATOM 1256 CD2 TYR A 387 −30.933 25.707 14.255 1.00 46.96 C ATOM 1257 C TYR A 387 −26.820 25.129 11.908 1.00 54.53 C ATOM 1258 O TYR A 387 −26.974 24.108 11.236 1.00 54.49 O ATOM 1259 N ALA A 388 −25.632 25.651 12.211 1.00 51.55 N ATOM 1260 CA ALA A 388 −24.368 24.975 11.971 1.00 51.75 C ATOM 1261 CB ALA A 388 −23.258 25.994 11.797 1.00 55.46 C ATOM 1262 C ALA A 388 −24.044 24.076 13.159 1.00 51.24 C ATOM 1263 O ALA A 388 −24.496 24.339 14.271 1.00 50.10 O ATOM 1264 N TRP A 389 −23.268 23.016 12.939 1.00 45.80 N ATOM 1265 CA TRP A 389 −22.907 22.127 14.055 1.00 47.94 C ATOM 1266 CB TRP A 389 −23.379 20.694 13.811 1.00 55.02 C ATOM 1267 CG TRP A 389 −22.997 20.096 12.466 1.00 61.96 C ATOM 1268 CD1 TRP A 389 −23.733 20.121 11.284 1.00 60.81 C ATOM 1269 NE1 TRP A 389 −23.066 19.479 10.278 1.00 58.40 N ATOM 1270 CE2 TRP A 389 −21.886 19.000 10.707 1.00 63.93 C ATOM 1271 CD2 TRP A 389 −21.761 19.370 12.121 1.00 61.33 C ATOM 1272 CE3 TRP A 389 −20.607 19.004 12.814 1.00 62.97 C ATOM 1273 CZ3 TRP A 389 −19.612 18.275 12.128 1.00 55.66 C ATOM 1274 CH2 TRP A 389 −19.759 17.933 10.776 1.00 59.86 C ATOM 1275 CZ2 TRP A 389 −20.889 18.295 10.037 1.00 60.84 C ATOM 1276 C TRP A 389 −21.452 22.176 14.331 1.00 48.46 C ATOM 1277 O TRP A 389 −20.665 22.430 13.417 1.00 53.89 O ATOM 1278 N THR A 390 −21.097 22.023 15.604 1.00 46.43 N ATOM 1279 CA THR A 390 −19.718 21.863 16.040 1.00 42.72 C ATOM 1280 CB THR A 390 −19.174 23.145 16.683 1.00 47.53 C ATOM 1281 OG1 THR A 390 −19.311 24.231 15.755 1.00 47.46 O ATOM 1282 CG2 THR A 390 −17.677 22.992 17.028 1.00 40.46 C ATOM 1283 C THR A 390 −19.628 20.716 17.061 1.00 46.44 C ATOM 1284 O THR A 390 −20.387 20.670 18.048 1.00 42.76 O ATOM 1285 N ILE A 391 −18.688 19.802 16.826 1.00 42.41 N ATOM 1286 CA ILE A 391 −18.476 18.637 17.667 1.00 40.33 C ATOM 1287 CB ILE A 391 −17.309 17.791 17.119 1.00 41.51 C ATOM 1288 CG1 ILE A 391 −17.683 17.254 15.766 1.00 44.96 C ATOM 1289 CD1 ILE A 391 −16.497 17.049 14.849 1.00 45.22 C ATOM 1290 CG2 ILE A 391 −16.964 16.644 18.082 1.00 45.22 C ATOM 1291 C ILE A 391 −18.132 19.028 19.095 1.00 38.44 C ATOM 1292 O ILE A 391 −17.345 19.924 19.318 1.00 43.16 O ATOM 1293 N ALA A 392 −18.671 18.299 20.061 1.00 41.48 N ATOM 1294 CA ALA A 392 −18.401 18.602 21.469 1.00 40.50 C ATOM 1295 CB ALA A 392 −19.625 19.267 22.086 1.00 36.53 C ATOM 1296 C ALA A 392 −18.113 17.310 22.204 1.00 44.24 C ATOM 1297 O ALA A 392 −18.925 16.368 22.130 1.00 41.57 O ATOM 1298 N GLN A 393 −17.013 17.290 22.966 1.00 45.37 N ATOM 1299 CA GLN A 393 −16.682 16.151 23.808 1.00 41.94 C ATOM 1300 CB GLN A 393 −15.485 15.394 23.195 1.00 46.38 C ATOM 1301 CG GLN A 393 −14.158 16.130 23.317 1.00 40.87 C ATOM 1302 CD GLN A 393 −13.092 15.637 22.333 1.00 49.74 C ATOM 1303 OE1 GLN A 393 −13.381 15.120 21.240 1.00 60.53 O ATOM 1304 NE2 GLN A 393 −11.850 15.854 22.697 1.00 50.95 N ATOM 1305 C GLN A 393 −16.380 16.469 25.274 1.00 44.97 C ATOM 1306 O GLN A 393 −16.041 17.580 25.608 1.00 46.77 O ATOM 1307 N CYS A 394 −16.482 15.453 26.132 1.00 41.89 N ATOM 1308 CA CYS A 394 −16.067 15.520 27.524 1.00 48.15 C ATOM 1309 CB CYS A 394 −16.088 14.136 28.139 1.00 47.98 C ATOM 1310 SG CYS A 394 −15.985 14.274 29.902 1.00 53.56 S ATOM 1311 C CYS A 394 −14.684 16.083 27.676 1.00 50.29 C ATOM 1312 O CYS A 394 −13.783 15.758 26.911 1.00 51.40 O ATOM 1313 N LYS A 395 −14.514 16.967 28.645 1.00 58.80 N ATOM 1314 CA LYS A 395 −13.245 17.654 28.768 1.00 58.39 C ATOM 1315 CB LYS A 395 −13.382 19.031 29.439 1.00 61.48 C ATOM 1316 CG LYS A 395 −14.058 18.984 30.782 1.00 67.98 C ATOM 1317 CD LYS A 395 −13.663 20.151 31.672 1.00 70.73 C ATOM 1318 CE LYS A 395 −14.036 19.816 33.116 1.00 68.12 C ATOM 1319 NZ LYS A 395 −14.124 21.001 34.013 1.00 64.24 N ATOM 1320 C LYS A 395 −12.324 16.755 29.540 1.00 58.11 C ATOM 1321 O LYS A 395 −11.128 16.883 29.410 1.00 54.52 O ATOM 1322 N ILE A 396 −12.904 15.838 30.325 1.00 59.76 N ATOM 1323 CA ILE A 396 −12.151 14.868 31.135 1.00 55.20 C ATOM 1324 CB ILE A 396 −13.024 14.298 32.281 1.00 62.35 C ATOM 1325 CG1 ILE A 396 −13.529 15.414 33.203 1.00 56.32 C ATOM 1326 CD1 ILE A 396 −12.470 16.338 33.739 1.00 62.62 C ATOM 1327 CG2 ILE A 396 −12.328 13.166 33.058 1.00 60.23 C ATOM 1328 C ILE A 396 −11.617 13.733 30.267 1.00 58.86 C ATOM 1329 O ILE A 396 −10.382 13.614 30.071 1.00 60.14 O ATOM 1330 N CYS A 397 −12.546 12.951 29.701 1.00 53.47 N ATOM 1331 CA CYS A 397 −12.247 11.654 29.081 1.00 56.06 C ATOM 1332 CB CYS A 397 −13.257 10.614 29.574 1.00 53.39 C ATOM 1333 SG CYS A 397 −14.852 10.712 28.712 1.00 53.83 S ATOM 1334 C CYS A 397 −12.307 11.670 27.561 1.00 60.07 C ATOM 1335 O CYS A 397 −11.992 10.684 26.896 1.00 65.82 O ATOM 1336 N ALA A 398 −12.765 12.776 26.998 1.00 60.44 N ATOM 1337 CA ALA A 398 −12.826 12.901 25.555 1.00 47.74 C ATOM 1338 CB ALA A 398 −11.496 12.460 24.944 1.00 52.19 C ATOM 1339 C ALA A 398 −13.999 12.170 24.901 1.00 47.71 C ATOM 1340 O ALA A 398 −14.087 12.149 23.678 1.00 44.78 O ATOM 1341 N SER A 399 −14.914 11.577 25.673 1.00 45.53 N ATOM 1342 CA SER A 399 −16.079 10.944 25.030 1.00 48.46 C ATOM 1343 CB SER A 399 −16.906 10.242 26.079 1.00 44.55 C ATOM 1344 OG SER A 399 −18.127 9.798 25.546 1.00 53.65 O ATOM 1345 C SER A 399 −16.958 11.936 24.203 1.00 57.68 C ATOM 1346 O SER A 399 −17.172 13.074 24.632 1.00 57.72 O ATOM 1347 N HIS A 400 −17.450 11.514 23.030 1.00 52.97 N ATOM 1348 CA HIS A 400 −18.225 12.385 22.147 1.00 56.67 C ATOM 1349 CB HIS A 400 −18.264 11.865 20.713 1.00 48.92 C ATOM 1350 CG HIS A 400 −16.969 12.035 19.998 1.00 59.48 C ATOM 1351 ND1 HIS A 400 −15.794 12.106 20.655 1.00 61.72 N ATOM 1352 CE1 HIS A 400 −14.806 12.237 19.763 1.00 62.17 C ATOM 1353 NE2 HIS A 400 −15.346 12.235 18.543 1.00 56.58 N ATOM 1354 CD2 HIS A 400 −16.675 12.121 18.653 1.00 58.53 C ATOM 1355 C HIS A 400 −19.603 12.492 22.632 1.00 59.47 C ATOM 1356 O HIS A 400 −20.384 11.560 22.470 1.00 65.12 O ATOM 1357 N ILE A 401 −19.956 13.623 23.230 1.00 52.92 N ATOM 1358 CA ILE A 401 −21.286 13.667 23.788 1.00 45.82 C ATOM 1359 CB ILE A 401 −21.300 14.482 25.078 1.00 47.51 C ATOM 1360 CG1 ILE A 401 −20.154 14.006 25.984 1.00 48.01 C ATOM 1361 CD1 ILE A 401 −20.429 12.742 26.777 1.00 47.02 C ATOM 1362 CG2 ILE A 401 −22.651 14.436 25.804 1.00 43.21 C ATOM 1363 C ILE A 401 −22.250 14.160 22.702 1.00 45.88 C ATOM 1364 O ILE A 401 −23.383 13.715 22.623 1.00 47.58 O ATOM 1365 N GLY A 402 −21.807 15.094 21.874 1.00 45.44 N ATOM 1366 CA GLY A 402 −22.694 15.608 20.855 1.00 41.84 C ATOM 1367 C GLY A 402 −22.195 16.864 20.201 1.00 42.30 C ATOM 1368 O GLY A 402 −21.032 16.922 19.773 1.00 44.96 O ATOM 1369 N TRP A 403 −23.068 17.882 20.128 1.00 36.73 N ATOM 1370 CA TRP A 403 −22.796 19.046 19.289 1.00 37.78 C ATOM 1371 CB TRP A 403 −23.451 18.859 17.900 1.00 38.58 C ATOM 1372 CG TRP A 403 −22.985 17.628 17.160 1.00 44.12 C ATOM 1373 CD1 TRP A 403 −21.931 17.532 16.244 1.00 42.52 C ATOM 1374 NE1 TRP A 403 −21.763 16.251 15.829 1.00 39.15 N ATOM 1375 CE2 TRP A 403 −22.650 15.416 16.432 1.00 47.67 C ATOM 1376 CD2 TRP A 403 −23.495 16.248 17.300 1.00 45.43 C ATOM 1377 CE3 TRP A 403 −24.536 15.647 18.020 1.00 46.26 C ATOM 1378 CZ3 TRP A 403 −24.725 14.257 17.904 1.00 49.94 C ATOM 1379 CH2 TRP A 403 −23.921 13.476 17.043 1.00 53.93 C ATOM 1380 CZ2 TRP A 403 −22.869 14.041 16.284 1.00 46.89 C ATOM 1381 C TRP A 403 −23.342 20.327 19.891 1.00 41.61 C ATOM 1382 O TRP A 403 −24.407 20.327 20.522 1.00 38.88 O ATOM 1383 N LYS A 404 −22.642 21.424 19.625 1.00 36.36 N ATOM 1384 CA LYS A 404 −23.180 22.743 19.755 1.00 42.82 C ATOM 1385 CB LYS A 404 −22.069 23.742 20.078 1.00 44.40 C ATOM 1386 CG LYS A 404 −22.567 25.124 20.549 1.00 47.41 C ATOM 1387 CD LYS A 404 −21.430 26.149 20.621 1.00 52.01 C ATOM 1388 CE LYS A 404 −21.605 27.125 21.786 1.00 59.97 C ATOM 1389 NZ LYS A 404 −20.430 28.027 22.061 1.00 57.40 N ATOM 1390 C LYS A 404 −23.819 23.117 18.431 1.00 45.19 C ATOM 1391 O LYS A 404 −23.175 22.983 17.388 1.00 48.81 O ATOM 1392 N PHE A 405 −25.072 23.569 18.469 1.00 38.31 N ATOM 1393 CA PHE A 405 −25.705 24.123 17.271 1.00 40.90 C ATOM 1394 CB PHE A 405 −27.094 23.496 17.069 1.00 39.47 C ATOM 1395 CG PHE A 405 −27.037 22.035 16.641 1.00 39.51 C ATOM 1396 CD1 PHE A 405 −26.885 21.693 15.275 1.00 39.99 C ATOM 1397 CE1 PHE A 405 −26.786 20.362 14.873 1.00 41.24 C ATOM 1398 CZ PHE A 405 −26.877 19.356 15.833 1.00 43.05 C ATOM 1399 CE2 PHE A 405 −27.015 19.690 17.184 1.00 43.92 C ATOM 1400 CD2 PHE A 405 −27.097 21.014 17.582 1.00 38.87 C ATOM 1401 C PHE A 405 −25.769 25.655 17.324 1.00 42.45 C ATOM 1402 O PHE A 405 −26.161 26.221 18.341 1.00 42.52 O ATOM 1403 N THR A 406 −25.339 26.328 16.257 1.00 43.08 N ATOM 1404 CA THR A 406 −25.296 27.802 16.239 1.00 46.58 C ATOM 1405 CB THR A 406 −23.841 28.323 16.135 1.00 48.64 C ATOM 1406 OG1 THR A 406 −23.115 27.450 15.281 1.00 47.40 O ATOM 1407 CG2 THR A 406 −23.144 28.325 17.488 1.00 41.25 C ATOM 1408 C THR A 406 −26.125 28.352 15.065 1.00 45.32 C ATOM 1409 O THR A 406 −25.953 27.902 13.938 1.00 46.96 O ATOM 1410 N ALA A 407 −27.044 29.290 15.326 1.00 42.01 N ATOM 1411 CA ALA A 407 −27.908 29.851 14.253 1.00 43.20 C ATOM 1412 CB ALA A 407 −28.890 30.890 14.827 1.00 36.73 C ATOM 1413 C ALA A 407 −27.110 30.499 13.120 1.00 40.45 C ATOM 1414 O ALA A 407 −26.270 31.319 13.385 1.00 40.73 O ATOM 1415 N THR A 408 −27.410 30.161 11.866 1.00 47.02 N ATOM 1416 CA THR A 408 −26.847 30.869 10.707 1.00 48.85 C ATOM 1417 CB THR A 408 −26.990 30.053 9.413 1.00 48.14 C ATOM 1418 OG1 THR A 408 −28.344 30.097 8.977 1.00 61.55 O ATOM 1419 CG2 THR A 408 −26.602 28.623 9.604 1.00 45.87 C ATOM 1420 C THR A 408 −27.465 32.283 10.468 1.00 57.62 C ATOM 1421 O THR A 408 −26.811 33.126 9.864 1.00 62.00 O ATOM 1422 N LYS A 409 −28.690 32.533 10.961 1.00 52.67 N ATOM 1423 CA LYS A 409 −29.369 33.872 10.887 1.00 56.68 C ATOM 1424 CB LYS A 409 −30.601 33.855 9.974 1.00 53.63 C ATOM 1425 CG LYS A 409 −30.261 33.596 8.524 1.00 68.12 C ATOM 1426 CD LYS A 409 −31.478 33.137 7.734 1.00 83.27 C ATOM 1427 CE LYS A 409 −32.061 34.259 6.878 1.00 84.67 C ATOM 1428 NZ LYS A 409 −33.306 34.824 7.466 1.00 87.15 N ATOM 1429 C LYS A 409 −29.748 34.481 12.235 1.00 46.56 C ATOM 1430 O LYS A 409 −30.131 33.795 13.170 1.00 45.30 O ATOM 1431 N LYS A 410 −29.606 35.791 12.316 1.00 48.26 N ATOM 1432 CA LYS A 410 −29.712 36.532 13.563 1.00 52.99 C ATOM 1433 CB LYS A 410 −29.044 37.886 13.396 1.00 56.59 C ATOM 1434 CG LYS A 410 −27.544 37.867 13.637 1.00 67.81 C ATOM 1435 CD LYS A 410 −27.196 38.721 14.851 1.00 70.64 C ATOM 1436 CE LYS A 410 −25.851 39.419 14.664 1.00 71.13 C ATOM 1437 NZ LYS A 410 −25.809 40.799 15.245 1.00 72.83 N ATOM 1438 C LYS A 410 −31.138 36.709 14.086 1.00 54.59 C ATOM 1439 O LYS A 410 −31.338 37.003 15.272 1.00 47.67 O ATOM 1440 N ASP A 411 −32.126 36.494 13.222 1.00 50.60 N ATOM 1441 CA ASP A 411 −33.499 36.594 13.669 1.00 55.97 C ATOM 1442 CB ASP A 411 −34.382 37.161 12.549 1.00 60.11 C ATOM 1443 CG ASP A 411 −34.525 36.224 11.359 1.00 62.81 C ATOM 1444 OD1 ASP A 411 −34.074 35.067 11.370 1.00 62.81 O ATOM 1445 0D2 ASP A 411 −35.119 36.663 10.375 1.00 64.67 O ATOM 1446 C ASP A 411 −34.088 35.300 14.281 1.00 56.90 C ATOM 1447 O ASP A 411 −35.233 35.307 14.706 1.00 63.74 O ATOM 1448 N MET A 412 −33.303 34.210 14.305 1.00 49.60 N ATOM 1449 CA MET A 412 −33.696 32.907 14.903 1.00 51.10 C ATOM 1450 CB MET A 412 −32.748 31.787 14.436 1.00 40.68 C ATOM 1451 CG MET A 412 −32.989 31.408 12.982 1.00 58.61 C ATOM 1452 SD MET A 412 −32.027 30.014 12.337 1.00 63.69 S ATOM 1453 CE MET A 412 −30.594 30.851 11.709 1.00 58.46 C ATOM 1454 C MET A 412 −33.676 32.894 16.425 1.00 48.39 C ATOM 1455 O MET A 412 −32.952 33.678 17.053 1.00 42.71 O ATOM 1456 N SER A 413 −34.414 31.957 17.026 1.00 44.90 N ATOM 1457 CA SER A 413 −34.235 31.744 18.446 1.00 42.44 C ATOM 1458 CB SER A 413 −35.302 32.474 19.227 1.00 42.13 C ATOM 1459 OG SER A 413 −36.572 31.990 18.812 1.00 46.24 O ATOM 1460 C SER A 413 −34.360 30.257 18.679 1.00 37.75 C ATOM 1461 O SER A 413 −35.225 29.640 18.086 1.00 38.47 O ATOM 1462 N PRO A 414 −33.515 29.678 19.560 1.00 33.40 N ATOM 1463 CA PRO A 414 −32.410 30.358 20.180 1.00 35.27 C ATOM 1464 CB PRO A 414 −32.070 29.457 21.356 1.00 37.15 C ATOM 1465 CG PRO A 414 −32.436 28.091 20.911 1.00 37.45 C ATOM 1466 CD PRO A 414 −33.674 28.301 20.075 1.00 36.86 C ATOM 1467 C PRO A 414 −31.225 30.528 19.228 1.00 37.68 C ATOM 1468 O PRO A 414 −31.229 29.925 18.146 1.00 34.36 O ATOM 1469 N GLN A 415 −30.268 31.404 19.573 1.00 37.06 N ATOM 1470 CA GLN A 415 −29.066 31.587 18.696 1.00 35.80 C ATOM 1471 CB GLN A 415 −28.296 32.908 18.990 1.00 38.30 C ATOM 1472 CG GLN A 415 −28.996 34.164 18.389 1.00 43.27 C ATOM 1473 CD GLN A 415 −28.987 34.180 16.846 1.00 41.84 C ATOM 1474 OE1 GLN A 415 −29.992 33.869 16.200 1.00 43.35 O ATOM 1475 NE2 GLN A 415 −27.865 34.531 16.262 1.00 39.58 N ATOM 1476 C GLN A 415 −28.119 30.401 18.756 1.00 33.60 C ATOM 1477 O GLN A 415 −27.382 30.139 17.823 1.00 34.13 O ATOM 1478 N LYS A 416 −28.200 29.674 19.856 1.00 39.79 N ATOM 1479 CA LYS A 416 −27.375 28.527 20.097 1.00 43.58 C ATOM 1480 CB LYS A 416 −26.003 28.954 20.686 1.00 50.16 C ATOM 1481 CG LYS A 416 −26.000 29.133 22.187 1.00 54.46 C ATOM 1482 CD LYS A 416 −24.815 29.949 22.676 1.00 54.77 C ATOM 1483 CE LYS A 416 −25.247 30.768 23.869 1.00 50.07 C ATOM 1484 NZ LYS A 416 −25.911 32.082 23.480 1.00 39.14 N ATOM 1485 C LYS A 416 −28.118 27.553 21.025 1.00 41.06 C ATOM 1486 O LYS A 416 −28.958 27.944 21.853 1.00 39.51 O ATOM 1487 N PHE A 417 −27.823 26.275 20.839 1.00 41.90 N ATOM 1488 CA PHE A 417 −28.221 25.224 21.750 1.00 39.41 C ATOM 1489 CB PHE A 417 −29.697 24.827 21.523 1.00 34.05 C ATOM 1490 CG PHE A 417 −29.963 24.160 20.207 1.00 35.43 C ATOM 1491 CD1 PHE A 417 −29.968 22.735 20.091 1.00 34.81 C ATOM 1492 CE1 PHE A 417 −30.216 22.142 18.839 1.00 35.79 C ATOM 1493 CZ PHE A 417 −30.509 22.944 17.720 1.00 33.80 C ATOM 1494 CE2 PHE A 417 −30.567 24.345 17.852 1.00 32.41 C ATOM 1495 CD2 PHE A 417 −30.296 24.929 19.085 1.00 32.34 C ATOM 1496 C PHE A 417 −27.265 24.011 21.566 1.00 38.54 C ATOM 1497 O PHE A 417 −26.400 24.036 20.678 1.00 42.55 O ATOM 1498 N TRP A 418 −27.472 22.951 22.368 1.00 33.60 N ATOM 1499 CA TRP A 418 −26.664 21.745 22.329 1.00 37.44 C ATOM 1500 CB TRP A 418 −25.983 21.492 23.668 1.00 37.59 C ATOM 1501 CG TRP A 418 −25.132 22.628 24.130 1.00 38.53 C ATOM 1502 CD1 TRP A 418 −25.553 23.753 24.847 1.00 40.93 C ATOM 1503 NE1 TRP A 418 −24.492 24.599 25.095 1.00 39.89 N ATOM 1504 CE2 TRP A 418 −23.332 24.092 24.557 1.00 45.82 C ATOM 1505 CD2 TRP A 418 −23.681 22.819 23.907 1.00 42.89 C ATOM 1506 CE3 TRP A 418 −22.662 22.069 23.287 1.00 42.54 C ATOM 1507 CZ3 TRP A 418 −21.371 22.569 23.294 1.00 44.20 C ATOM 1508 CH2 TRP A 418 −21.055 23.807 23.930 1.00 45.59 C ATOM 1509 CZ2 TRP A 418 −22.018 24.573 24.575 1.00 38.75 C ATOM 1510 C TRP A 418 −27.532 20.560 21.999 1.00 39.78 C ATOM 1511 O TRP A 418 −28.676 20.460 22.473 1.00 36.22 O ATOM 1512 N GLY A 419 −26.977 19.648 21.197 1.00 43.31 N ATOM 1513 CA GLY A 419 −27.676 18.410 20.786 1.00 40.79 C ATOM 1514 C GLY A 419 −26.857 17.291 21.372 1.00 38.98 C ATOM 1515 O GLY A 419 −25.721 17.096 20.980 1.00 41.76 O ATOM 1516 N LEU A 420 −27.447 16.564 22.310 1.00 42.02 N ATOM 1517 CA LEU A 420 −26.730 15.576 23.083 1.00 43.66 C ATOM 1518 CB LEU A 420 −26.794 15.907 24.569 1.00 41.30 C ATOM 1519 CG LEU A 420 −26.281 17.276 25.020 1.00 43.93 C ATOM 1520 CD1 LEU A 420 −26.274 17.287 26.545 1.00 45.97 C ATOM 1521 CD2 LEU A 420 −24.904 17.620 24.432 1.00 44.93 C ATOM 1522 C LEU A 420 −27.300 14.196 22.843 1.00 45.63 C ATOM 1523 O LEU A 420 −28.523 13.983 22.988 1.00 47.89 O ATOM 1524 N THR A 421 −26.403 13.275 22.475 1.00 47.19 N ATOM 1525 CA THR A 421 −26.755 11.873 22.179 1.00 50.41 C ATOM 1526 CB THR A 421 −25.580 11.141 21.497 1.00 57.95 C ATOM 1527 OG1 THR A 421 −25.099 11.920 20.399 1.00 53.64 O ATOM 1528 CG2 THR A 421 −26.023 9.735 20.980 1.00 59.01 C ATOM 1529 C THR A 421 −27.133 11.185 23.483 1.00 47.41 C ATOM 1530 O THR A 421 −26.315 11.072 24.382 1.00 42.69 O ATOM 1531 N ARG A 422 −28.403 10.830 23.627 1.00 50.09 N ATOM 1532 CA ARG A 422 −28.910 10.249 24.875 1.00 53.93 C ATOM 1533 CB ARG A 422 −30.353 9.743 24.671 1.00 59.09 C ATOM 1534 CG ARG A 422 −31.413 10.603 25.351 1.00 70.59 C ATOM 1535 CD ARG A 422 −32.758 9.888 25.504 1.00 76.14 C ATOM 1536 NE ARG A 422 −33.693 10.198 24.41 1.00 87.31 N ATOM 1537 CZ ARG A 422 −34.200 11.409 24.159 1.00 89.80 C ATOM 1538 NH1 ARG A 422 −33.862 12.444 24.913 1.00 92.14 N ATOM 1539 NH2 ARG A 422 −35.044 11.600 23.147 1.00 82.65 N ATOM 1540 C ARG A 422 −28.029 9.095 25.397 1.00 59.55 C ATOM 1541 O ARG A 422 −27.778 8.963 26.600 1.00 55.46 O ATOM 1542 N SER A 423 −27.561 8.246 24.490 1.00 58.91 N ATOM 1543 CA SER A 423 −26.897 7.040 24.959 1.00 65.33 C ATOM 1544 CB SER A 423 −26.910 5.919 23.884 1.00 53.93 C ATOM 1545 OG SER A 423 −25.971 6.168 22.859 1.00 62.93 O ATOM 1546 C SER A 423 −25.498 7.389 25.497 1.00 67.39 C ATOM 1547 O SER A 423 −24.847 6.539 26.110 1.00 64.90 O ATOM 1548 N ALA A 424 −25.048 8.646 25.315 1.00 56.20 N ATOM 1549 CA ALA A 424 −23.737 9.041 25.835 1.00 49.33 C ATOM 1550 CB ALA A 424 −23.026 9.967 24.875 1.00 49.27 C ATOM 1551 C ALA A 424 −23.799 9.636 27.239 1.00 53.75 C ATOM 1552 O ALA A 424 −22.765 10.037 27.813 1.00 59.49 O ATOM 1553 N LEU A 425 −24.995 9.639 27.821 1.00 48.80 N ATOM 1554 CA LEU A 425 −25.202 10.259 29.140 1.00 56.48 C ATOM 1555 CB LEU A 425 −26.202 11.423 28.987 1.00 56.27 C ATOM 1556 CG LEU A 425 −25.822 12.571 28.057 1.00 55.42 C ATOM 1557 CD1 LEU A 425 −27.011 13.497 27.869 1.00 52.51 C ATOM 1558 CD2 LEU A 425 −24.651 13.316 28.687 1.00 56.42 C ATOM 1559 C LEU A 425 −25.722 9.264 30.170 1.00 51.66 C ATOM 1560 O LEU A 425 −26.254 8.226 29.786 1.00 62.08 O ATOM 1561 N LEU A 426 −25.593 9.576 31.460 1.00 52.97 N ATOM 1562 CA LEU A 426 −26.245 8.775 32.509 1.00 60.78 C ATOM 1563 CB LEU A 426 −25.238 7.986 33.358 1.00 62.95 C ATOM 1564 CG LEU A 426 −24.984 6.515 32.925 1.00 74.12 C ATOM 1565 CD1 LEU A 426 −24.024 5.859 33.903 1.00 71.58 C ATOM 1566 CD2 LEU A 426 −26.234 5.629 32.719 1.00 65.84 C ATOM 1567 C LEU A 426 −27.290 9.495 33.366 1.00 63.28 C ATOM 1568 O LEU A 426 −27.105 10.649 33.686 1.00 64.25 O ATOM 1569 N PRO A 427 −28.291 8.749 33.872 1.00 75.24 N ATOM 1570 CA PRO A 427 −29.720 8.955 33.938 1.00 80.59 C ATOM 1571 CB PRO A 427 −29.868 9.778 35.216 1.00 84.11 C ATOM 1572 CG PRO A 427 −28.765 9.224 36.105 1.00 87.05 C ATOM 1573 CD PRO A 427 −27.865 8.362 35.229 1.00 86.56 C ATOM 1574 C PRO A 427 −30.291 9.651 32.713 1.00 83.29 C ATOM 1575 O PRO A 427 −29.994 9.220 31.596 1.00 78.84 O ATOM 1576 04 SO4 B 1 −6.780 3.107 0.782 0.50 55.03 O ATOM 1577 S SO4 B 1 −6.029 2.170 0.074 0.50 54.80 S ATOM 1578 O1 SO4 B 1 −4.565 2.401 0.097 0.50 58.00 O ATOM 1579 O2 SO4 B 1 −6.458 2.438 1.462 0.50 49.67 O ATOM 1580 O3 SO4 B 1 −6.297 0.773 0.307 0.50 53.83 O ATOM 1581 O4 SO4 B 2 −0.580 0.259 1.180 0.30 35.16 O ATOM 1582 S SO4 B 2 −1.057 0.990 0.964 0.30 34.90 S ATOM 1583 O1 SO4 B 2 −0.558 1.519 0.182 0.30 36.43 O ATOM 1584 O2 SO4 B 2 −0.682 1.755 1.988 0.30 35.33 O ATOM 1585 O3 SO4 B 2 −2.418 0.997 0.928 0.30 33.76 O ATOM 1586 O4 SO4 B 3 −2.177 0.336 4.453 0.50 40.70 ZN ATOM 1587 S SO4 B 3 −1.783 0.126 5.881 0.50 40.38 ZN ATOM 1588 O1 SO4 B 3 −2.811 0.622 6.819 0.50 39.17 O ATOM 1589 O2 SO4 B 3 −0.546 0.912 5.979 0.50 40.18 O ATOM 1590 O3 SO4 B 3 −1.601 1.301 6.178 0.50 44.17 O ATOM 1591 O4 SO4 B 4 −28.980 34.035 22.827 0.50 50.39 O ATOM 1592 S SO4 B 4 −30.024 32.990 22.735 0.50 50.79 S ATOM 1593 O1 SO4 B 4 −29.392 31.765 22.156 0.50 49.15 O ATOM 1594 O2 SO4 B 4 −31.178 33.475 21.919 0.50 44.58 O ATOM 1595 O3 SO4 B 4 −30.494 32.644 24.092 0.50 43.93 O ATOM 1596 O4 SO4 B 5 −28.084 33.478 27.010 0.50 58.70 O ATOM 1597 S SO4 B 5 −26.741 32.887 26.875 0.33 58.19 S ATOM 1598 O1 SO4 B 5 −25.831 33.787 26.132 0.33 60.90 O ATOM 1599 O2 SO4 B 5 −26.885 31.590 26.189 0.50 58.81 O ATOM 1600 O3 SO4 B 5 −26.226 32.618 28.230 0.50 57.58 O ATOM 1601 O4 SO4 B 6 −21.748 30.361 26.457 0.50 50.00 O ATOM 1602 S SO4 B 6 −22.401 29.102 26.030 0.50 440.04 S ATOM 1603 O1 SO4 B 6 −22.378 29.007 24.546 0.50 40.17 O ATOM 1604 O2 SO4 B 6 −23.779 29.118 26.605 0.50 41.89 O ATOM 1605 O3 SO4 B 6 −21.665 27.934 26.545 0.50 41.23 O ATOM 1606 ZN ZN C 1 −16.053 11.896 30.232 1.00 57.84 ZN ATOM 1607 ZN ZN C 2 −13.578 16.559 8.567 1.00 48.31 ZN ATOM 1608 O HOH E 1 −35.314 17.552 23.944 1.00 47.35 O ATOM 1609 O HOH E 2 0.054 4.032 −2.779 1.00 36.31 O ATOM 1610 O HOH E 3 4.531 2.010 −4.613 1.00 38.13 O END

A search for structural homologs to the TBD reveals that despite very low sequence identity (<14%), the same fold is found in other proteins including methionine sulfoxide reductase (MSR), an enzyme involved in the repair of oxidized proteins, dsRNA binding proteins RIG-I, MDA5 and LGP2 which are involved in sensing viral RNAs as part of the innate immune response (Lu et al. Structure, 2010. 18(8):1032-43; Li et al. J Biol Chem, 2009. 284(20): 13881-91). Despite sharing the same fold, the tri-Trp pocket residues are not conserved in any of these structurally similar proteins, indicating that these cannot bind immunomodulatory agent drugs in the same manner as CRBN. However, CRBN orthologues can be identified across animal and plant kingdoms, and these proteins exhibit 100% sequence conservation in the immunomodulatory agent drug binding pocket (FIG. 19). This level of sequence conservation is indicative of strong functional constraint(s), which suggests there may be an endogenous ligand with which immunomodulatory agent drugs compete. Tryptophan residues 380 (W380), 386 (W386) and 400 (W400) are fully conserved across CRBN orthologues (FIG. 19). The glutarimide binding pocket formed by these three tryptophan residues is reminiscent of the aromatic pockets used for binding methylated lysine and/or arginine found in royal family proteins containing chromodomains, tudor domains, plant homeo domain (PHD) fingers and malignant brain tumor (MBT) repeats, as well as bromodomains for binding to acetylated lysines and the tryptophan box of betaine-binding proteins such as ProX31 and BetP32. However, our isothermal titration calorimetry (ITC) analysis showed no significant binding affinity to modified lysines, arginines or betaines (data not shown).

A combination of mutations at both Tyrosine 384 (Y384) and W386 has been reported to cause a loss of the immunomodulatory agent drug effects. As shown in FIG. 15, W386 is part of the lenalidomide binding site and mutation of that residue would be expected to have consequences for immunomodulatory agent drug binding. Y384 however does not make any direct interactions with lenalidomide, and might be expected to have a more general effect on the stability of the domain.

6.9.3.2 Mutational Analysis of Residues Proximal to the Immunomodulatory Agent Binding Site

To better understand the role of the residues involved in the CRBN-immunomodulatory agent interactions in a cellular context, we performed mutagenesis of residues W386 or W400 to alanine and used lentiviral expression vectors to re-express full length wild type (CRBN^(WT)), W386A (CRBN^(W386A)) or W400A (CRBN^(W400A)) mutant versions of CRBN in a CRBN deficient myeloma cell line (DF15R) (Lopez-Girona et al., Leukemia. 26(11):2326-35). Transduction of the lentiviral constructs into DF15R cells and selection with puromycin generated cell lines that stably expressed wild type or mutant forms of CRBN at levels similar to the matched immunomodulatory agent-sensitive DF15 cell line (Lopez-Girona et al., Leukemia. 26(11):2326-35) (FIGS. 24A-24B). Immunoprecipitation-Western blotting analysis confirmed that similar to recombinant, wild type CRBN, mutants CRBN^(W386A) and CRBN^(W400A) interacted with DDB1 indicating that these proteins were properly folded and competent to form CRL4^(cRBN) complexes in cells (FIG. 24C) (Ito et al., Science, 2010. 327(5971):1345-50). Cell extracts from these lines were then used to assay the ability of CRBN to bind immunomodulatory agent compound. We used the thalidomide analog-coupled affinity bead assay (Ito et al., Science, 2010. 327(5971):1345-50; Lopez-Girona et al., Leukemia. 26(11):2326-35) (FIG. 24D) to demonstrate binding of recombinant CRBN to immunomodulatory agent compounds in cell extracts. Similar to the endogenous protein in DF15 cell extracts, the recombinant CRBN^(WT) expressed in DF15R was able to bind thalidomide analog-beads (FIG. 22A), and preincubation of cell extracts with free thalidomide or pomalidomide competed for binding to the beads. In contrast, the tryptophan mutants CRBN^(W386A) and CRBN^(W400A) were unable to bind thalidomide analog-beads (FIG. 22A), consistent with the structural information that both tryptophan residues in CRBN are needed for the interaction with immunomodulatory agent compounds.

The antiproliferative effect of immunomodulatory agent compounds on myeloma cells is mediated through CRBN protein. Thus, engineered cells (FIG. 25) (Lopez-Girona et al., Leukemia. 26(11):2326-35; Zhu et al., Blood. 2011. 118(18):4771-9) or cells made resistant to immunomodulatory agent drugs (Lopez-Girona et al., Leukemia. 26(11):2326-35) that lack detectable levels of CRBN, e.g., DF15R, become insensitive to the antiproliferative effects of the immunomodulatory agent compounds (FIG. 22B; FIG. 25). Significantly, the re-expression of a single recombinant protein, CRBN^(WT), is sufficient to restore the sensitivity to immunomodulatory agent compounds in the resistant line DF15R (FIG. 22B) as well as in other cell lines (data not shown). In these cells, re-expression of CRBN^(WT) also restores immunomodulatory agent-induced degradation of aiolos, and, as expected, restores the inhibition of c-Myc, IRF4, and phophorylated pRB expression (FIG. 22C). All of these downstream effects are consistent with the regained antiproliferative effect of pomalidomide (Gandhi et al., Br J Haematol.; Lu et al., Science; Kronke, et al., Science, 2014. 343(6168):301-5; Lopez-Girona et al. Br J Haematol, 2011. 154(3):325-36). In contrast, expression of the immunomodulatory agent-binding defective mutants, CRBN^(W386A) or CRBN^(W400A), does not re-sensitize DF15R cells to the antiproliferative effects of immunomodulatory agent drugs (FIGS. 22B and 22C). These cellular data are consistent with the structural data indicating that both W386 and W400 residues mediate CRBN binding to immunomodulatory agents, and CRBN mediates the antiproliferative effects characteristic of immunomodulatory agent compounds in myeloma cells.

6.9.3.3 Mutation of Variable Residues in the Immunomodulatory Agent Binding Site of CRBN

Since we hypothesized that immunomodulatory agents are essential for altering the interaction between CRBN and substrate, we also investigated the role of other proximal residues. It is known that rodents do not respond to immunomodulatory agent drugs in the same way that humans do. Rodents appear to be resistant to the IL-2 induction (FIG. 26), antiproliferative effects and also immunomodulatory agent compound induced teratogenicity (Newman et al., Reprod Toxicol, 1993. 7(4):359-90). A key step in understanding immunomodulatory agent biology and ultimately engineering immunomodulatory agent analogs without teratogenicity may indeed come from pin-pointing the key features which underlie the biological differences seen between rodents and humans. Within the immunomodulatory agent binding domain there are four differences between mouse and human proteins. Two of the variable residues are proximal to the immunomodulatory agent binding site (FIG. 19). One of these residues features a substantial change in properties from an acidic residue (glutamate 377) in human to a hydrophobic residue (valine) in mouse and rat.

To probe the function of the residues proximal to the bound immunomodulatory agent drug, we performed mutagenesis of residue E377 to valine in the human CRBN sequence and re-expressed the protein using a lentiviral system in DF15R cells. Cell extracts from this line were used to assay the ability of CRBN^(E377V) to bind Immunomodulatory agent compound. Similar to the recombinant CRBN^(WT), but in contrast to the CRBN^(W386A) or CRBN^(W400A) mutants, the CRBN^(E377V) mutant was able to bind thalidomide analog-beads, and this binding was competed by preincubation of cell extracts with free thalidomide or pomalidomide comparable to CRBN^(WT) (FIG. 23A). This is consistent with the structure that shows E377V is proximal to but does not directly interact with bound lenalidomide. CRBN^(E377V) re-expression in DF15R was unable to rescue sensitivity to pomalidomide or to rescue the degradation of Aiolos (FIG. 23B and FIG. 23B insert). Immunomodulatory agent binding to CRBN has been shown to enhance both the recruitment to CRL4^(CRBN) and the degradation of Ikaros and Aiolos Gandhi et al., Br J Haematol.; Lu et al., Science; Kronke, et al., Science, 2014. 343(6168):301-5). To determine whether Aiolos binding had been altered, we performed pull-down assays to compare the ability of CRBN^(WT) or CRBN^(E377V) to interact with Aiolos in the presence or absence of immunomodulatory agent compounds.

The function of the residues proximal to the bound immunomodulatory agent drug in degradation of CRBN substrates induced by immunomodulatory agent drug was studied. 293FT CRBN−/− cells were transiently transfected with plasmids expressing V5-tagged IKZF1, FLAG-tagged IKZF3, Myc-tagged Substrate X, GFP, human CRNB (hCRBN) or variants thereof, or mouse CRBN (mCRBN) or variants thereof. Thirty-six hours after transfection, cells were treated with DMSO, 10 μM lenalidomide or 1 μM Compound C for additional 12 hours. Cells were then wished with ice-cold 1×PBS twice, lysed in buffer A [50 mM Tris. CL, 150 mM NaCL, 1% triton-x 100, complete protease inhibitor tablet (roche), phosphatase inhibitor tablet (roche)]. Whole cell extracts were then harvested and subjected to immunoblot analysis. The results are shown in FIG. 27. As shown, V388 is essential for the destruction of Ikaros (IKZF1) or Aiolos (IKZF3) by lenalidomide. This result indicates that residue 388 of CRBN plays an important role in degradation of CRBN substrates, e.g., Ikaros or Aiolos, induced by immunomodulatory agent drug.

6.9.4. Discussion

Ito et al. first reported CRBN as the primary molecular target of thalidomide, and through mutagenesis demonstrated that the C-terminal domain encompassed the thalidomide binding domain (Ito et al., Science, 2010. 327(5971):1345-50).

Herein, we have presented the crystal structure of CRBN in complex with DDB1 and lenalidomide, thus providing the first structural description of immunomodulatory agent drug binding. The immunomodulatory agent-binding site is a shallow hydrophobic pocket on the surface of CRBN: three tryptophan residues form the binding site for the glutarimide ring of the immunomodulatory agent drug, with 3 hydrogen bonds observed between CRBN and the glutarimide ring. The glutarimide ring is a defining feature of the immunomodulatory agent class of molecules and all immunomodulatory agent-CRBN structures solved to date replicate the CRBN-immunomodulatory agent binding interaction described herein.

We have demonstrated that immunomodulatory agent binding and cellular function is dependent upon these key tryptophan interactions by comparing mutant knock-ins to wild type CRBN in a CRBN-deficient myeloma cell line, DF15R. We further used the knock-in system to study a glutamate residue, E377, which although proximal to bound lenalidomide, does not directly interact with the ligand. E377 is of keen interest as this residue is a valine in rodent species, which are resistant to teratogenic and other cellular immunomodulatory agent drug effects. We observe that knock-in of a human E377V mutant CRBN behaves in an identical manner to the knock-in of murine CRBN into our human myeloma cell line: neither mouse CRBN, nor human E377V mutant CRBN are able to rescue the immunomodulatory agent response although immunomodulatory agent binding is clearly evident (FIG. 23). In addition, we found that residue 388 of CRBN is essential for the destruction of Aiolos and Ikaros by lenalidomide. Of note is that we have not detected an E377V mutation in the setting of clinical resistance but our work here implies that a single amino acid change could mediate resistance to immunomodulatory agent drugs. CRBN down-regulation is certainly a mode of immunomodulatory agent resistance as evidenced by our in vitro experiments and has been suggested by a number of reports as a mechanism for innate or acquired resistance to immunomodulatory agent drugs in the clinical setting.

We establish that immunomodulatory agent drug binding alone, although necessary for inducing the E3 ligase mediated degradation of Aiolos and Ikaros, may not be sufficient as demonstrated here with the E377V mutant. Interestingly, the lenalidomide isoindolinone group is presented on the surface of the CRBN protein. This binding mode generates a surface with a number of available hydrogen bonds from both the protein and lenalidomide in the proximity of an exposed hydrophobic group. Immunomodulatory agent drug binding to CRBN has been demonstrated to increase the recruitment of substrates (e.g., Ikaros and Aiolos) to the ubiquitin ligase complex and enhance their degradation Gandhi et al., Br J Haematol.; Lu et al., Science; Kronke, et al., Science, 2014. 343(6168):301-5.). It is an interesting finding by us that V388 of CRBN is essential for immunomodulatory agent drug (e.g., lenalidomide) induced degradation of Ikaros and Aiolos. The unsatisfied bonding potential around the bound immunomodulatory agent drug could therefore form the basis of an artificially introduced interaction hotspot, thereby conferring a pharmacologically induced ‘neomorphic’ function to this E3 ligase.

However, in the case of CRBN, we have shown that the immunomodulatory agent binding pocket is extremely conserved across the known orthologues, which indicates that immunomodulatory agent drugs may be binding in place of an endogenous ligand, which has yet to be identified. There are several examples of endogenous ligands that have been demonstrated to regulate substrate recruitment to ubiquitin ligase complexes in plant systems. For example, auxin and jasmonate are small molecule regulators of ligases in plants (Tan et al. Nature, 2007. 446(7136):640-5; Chini et al., Nature, 2007. 448(7154):666-71). Similarly, a number of natural products exhibit pharmacological activity by scaffolding macromolecular interactions (Thiel et al. Angew Chem Int Ed Engl, 2012. 51(9):2012-8).

The ability for a small molecule to scaffold a specific macromolecular interaction to an E3 ubiquitin ligase has particularly exciting implications for drug discovery. We have observed several categories of variation proximal to the immunomodulatory agent drug binding site: variations in the presentation and substitution pattern of the solvent exposed ligand groups, protein conformational differences, and species sequence differences. To fully rationalize the role of these in immunomodulatory agent drug biology, several further advancements are anticipated, such as identification of the endogenous ligand(s) and the binding mode of the substrate proteins, such as Aiolos, when recruited to the Cul4:Rbx1:DDB1:CRBN complex upon immunomodulatory agent drug treatment. By describing the crystal structure of an immunomodulatory agent bound to CRBN, a substrate adapter for an E3 ubiquitin ligase, progress towards the rational design of ubiquitin ligase modulators is made.

6.10 Compound C-Induced Recruitment of GSPT1 to CRBN and the Crystal Structure of CRBN-DDB1-GSPT1-Compound C Complex

6.10.1 Summary

CRBN is the biological receptor for immunomodulatory drugs, which alter the specificity of the CRBN E3 ubiquitin ligase to confer differential patterns of substrate ubiquitylation and degradation. Here we report the structure of CRBN in complex with a novel small molecule CRBN modulator, Compound C, and a novel substrate, the translation termination factor GSPT1. GSPT1 binding is mediated by a surface turn which interacts with both Compound C and a “hotspot” on the CRBN surface. Substrate interactions with CRBN are predominantly backbone mediated with a Glycine (G) residue at a key position. We provide a molecular/mechanistic understanding of Compound C-directed GSPT1 recruitment, and define a structural degron that may underlie CRBN substrate selectivity. Finally, despite potent anti-tumor effects in humans, rodents remain resistant to Compound C effects via a CRBN mutation, E377V.

6.10.2 Materials and Methods

6.10.2.1 Protein Expression and Purification

Purification of CRBN-DDB1 was performed essentially as previously described (Chamberlain 2014). 6×His-ZZ-domain-thrombin tagged human CRBN (amino acids 40-442) and full length human DDB1 were co-expressed in SF9 insect cells in ESF921 medium in the presence of 50 uM zinc acetate. Cells were resuspended in buffer containing 50 mM Tris-HCl pH 7.5, 500 mM NaCl, 10 mM imidazole, 10% Glycerol, 2 mM TCEP, 1× Protease Inhibitor Cocktail (San Diego Biosciences, San Diego, Calif.), and 40,000U Benzonase (Novagen, Billerica, Mass.), and sonicated for 30 s. Lysate was clarified by high speed spin at 30,000 rpm for 30 minutes, and incubated with Ni-NTA affinity resin (Qiagen, Germany) for 1 hour. Complex was eluted with 500 mM imidazole, and the 6×his-zz-domain tag removed by thrombin (Enzyme Research Laboratories, South Bend, Ind.) cleavage overnight combined with dialysis into 10 mM imidazole buffer. Cleaved eluate was incubated with Ni-NTA sepharose, and the flow-through diluted to 200 mM NaCl for further purification over an ANX HiTrap ion exchange column (GE Healthcare, Piscataway, N.J.). The ANX column was washed with 10 column volumes of 50 mM Tris-HCl pH 7.5, 200 mM NaCl, 3 mM TCEP, followed by 10 column volumes of 50 mM Bis-Tris pH 6.0, 200 mM NaCl, 3 mM TCEP, and the CRBN-DDB1 peak eluted at 210 mM NaCl. The peak was collected and further purified by size exclusion chromatography using a Sephacryl 400 16/60 (GE Healthcare, Piscataway, N.J.) in buffer containing 10 mM HEPES pH 7, 240 mM NaCl, 3.0 mM TECP. The CRBN-DDB1 complex was concentrated to 30 mg/mL for crystallization trials.

GSPT1 domains 2 and 3 (amino acids 437-633) was expressed as an MBP-fusion in E. coli BL21 (DE3) star cells (Life Technologies, Carlsbad, Calif.) using 2XYT media (Teknova, Hollister, Calif.). Cells were induced at OD₆₀₀ 0.6 for 18 hours at 16° C. Cells were pelleted, resuspended in buffer containing 200 mM NaCl, 50 mM Tris pH 7.5, 1 mM TCEP, 10% glycerol, x mg/mL lysozyme, 10,000 U benzonase, and 1×SD Bioscience protease inhibitors. Resuspended cells were frozen, thawed for purification, and sonicated for 30 s before high speed spin at 30,000 rpm for 30 minutes. Clarified lysate was incubated with maltose resin (NEB) at 4° C. for 1 hour before beads were washed. Protein was eluted with buffer containing 10 mM maltose, and the MBP tag was removed by overnight cleavage with thrombin (Enzyme Research Laboratories, South Bend, Ind.). Cleaved GSPT1 was diluted into buffer containing 90 mM Nacl and further separated over a Heparin HiTrap column (GE healthcare, Piscataway, N.J.). The GSPT1 peak eluting at 100 mM NaCl was collected, concentrated, and further separated by size exclusion chromatography over a Sepharose 75 16/60 column (GE Healthcare, Piscataway, N.J.) in buffer containing 10 mM HEPES pH7, 240 mM NaCl, 3.0 mM TECP. GSPT1 eluted at 75 mL and was concentrated to 16 mg/mL for crystallization trials.

6.10.2.2 Crystallization and Structure Determination

Crystallization of the complex was achieved by sitting drop vapor diffusion. CRBN-DDB1 and GSPT1 were mixed together to equimolar stoichiometry at a final concentration of 170 uM. The solution of CRBN-DDB1-GSPT1 in the presence of 500 uM Compound C was mixed 1:1 with, and subsequently equilibrated against a mother liquor solution of 200 mM sodium citrate, Tris-HCl pH 8.4-8.6, 17-20% PEG 3350 and incubated at 9° C. Crystals were cryoprotected in the reservoir solution supplemented with 20% Ethylene glycol and cooled under liquid nitrogen. Data were collected from a single crystal at the Advanced Light Source, beamline 5.0.2. The structure of human CRBN-DDB1-GSPT1-Compound C was solved by molecular replacement using Phaser, with human CRBN-DDB1 (PDB code 4TZ4) and GSPT1 (pdb code 3E1Y) as search models. Subsequent manual model building using Coot and refinement were performed using Refmac5 with non-crystallographic symmetry and external structure restraints. Crystallographic statistics are summarized in Table 9.

TABLE 9 Crystallographic Statistics CRBN-DDB1-Compound C-GSPT1 Data collection Space group P2 Cell dimensions a, b, c (Å) 156.8 111.5 175.1 α, β, γ (°) 90 95.8 90 Resolution (Å)   50-3.6 (3.66-3.6)* R_(merge) (%) 19.8 (79.6) I/σI 10.6 (2.1)  Completeness (%) 94.4 (93.9) Redundancy 4.8 (4.5) Refinement Resolution (Å) 50.0-3.6 No. reflections 62827 R_(work)/R_(free) 0.223/0.279 No. atoms Protein 25202 Ligand/ion 62/2  Water 0 B factors Protein 117.9 Ligand/ion  99.9/167.6 Water N/A r.m.s. deviations Bond lengths (Å) 0.015 Bond angles (°) 1.853 *Values in parentheses are for highest-resolution shell.

6.10.2.3 Surface Plasmon Resonance Binding Assay

Binding kinetics was measured using a Biacore T200. Using the GST-capture kit (GE Healthcare, BR-1002-23), ˜2000 RU of anti-GST antibody was immobilized on a CM5 chip (GE Healthcare, Piscataway, N.J.). GST-GSTP1-domain 2 and 3 (0.07 ug/mL) or GST (0.15 ug/mL, reference channel) was then flowed over the chip at 10 ul/min for 2 min, resulting in a capture level of approximately 10 RU. A 3-fold dilution series of CRBN-DDB1 (3 uM to 3 nM) was then flown over both channels at a rate of 30 ul/min for 300 s contact time, followed by 900 s dissociation time. After each cycle of binding and dissociation, the surface was regenerated with 10 mM glycine pH 2.1 for 120 s at 30 ul/min, followed by 3M MgCl₂ for 60 s at 30 ul/min. All reagents (GST, GST-GSPT1 domain 2 and 3, CRBN-DDB1, and running buffer) were in 10 mM HEPES pH 7.4, 150 mM NaCl, 0.05% v/v Surfactant P20 containing 0.02% DMSO and saturating levels of the relevant compound, glutarimide or Compound C (Compound C at 10 uM, Glutarimide at 100 uM given its significantly lower affinity for CRBN). The apparent on- and off-rate constants were globally fit with a 1:1 kinetic binding model to the sensograms (black lines) using the Bioacore T200 kinetic analysis software package.

6.10.2.4 Co-Immunoprecipitation of CRBN-DDB1 with Substrates

Co-immunoprecipitation of CRBN-DDB1 with either GSPT1 or IKZF1 was performed using the same protocol. Tagged substrate, either GST-GSPT1-domain 3 (a.a. 526-633) or MBP-IKZF1 (a.a. 140-168), was expressed in bacteria and purified using affinity and size exclusion chromatography. Substrate was then bound to magnetic beads for 1 hour. Beads were washed 3 times in IP buffer (50 mM Tris pH 7.5, 150 mM NaCl, 10% glycerol, 0.01% NP-40, 1 mM TCEP) to remove excess unbound substrate, before the addition of DMSO or 100 uM compound (Compound C for GSPT1 and pomalidomide for IKZF1) and 50 uM CRBN-DDB1, purified from insect cells using affinity, ion exchange, and size exclusion chromatography. After one hour incubation with occasional gentle mixing at room temperature, unbound CRBN-DDB1 was removed and beads were washed 3 times in IP buffer, for a total of around 30 s. Substrate and co-immunoprecipitated CRBN-DDB1 was eluted using either 20 mM reduced glutathione or 10 mM maltose, separated by SDS-PAGE, and coomassie stained.

6.10.3 Results

6.10.3.1 a Truncated Form of Human GSPT1 Maintained the Functionality of the Full-Length Protein

FIG. 28A illustrates a full-length human GSPT1 and a truncated mutant form, which lacks the N-terminal 138 amino acid residues. FIG. 28B shows that, in 293T HEK cells, Compound C induced degradation of the full-length GSPT1 and the truncated form. FIG. 28C shows that Compound C induced interaction of CRBN with the full-length GSPT1 as well as the truncated GSPT1. Thus, the truncated mutant human GSPT1 maintained the functionality of the full-length protein and can be used in studies below.

6.10.3.2 Glycine (G) 575 in Human GSPT1 is Essential for the Functionality of GSPT1

FIG. 29A shows a high degree of homology between the human GSPT1 and the yeast homologue SUP35. However, FIG. 29B shows that SUP35 did not exhibit Compound C-induced degradation, in contrast to human GSPT1.

To determine the critical region in the human GSPT1 that contributes to the Compound C-induced degradation, a plethora of chimeric constructs containing various domains of human GSPT1 and yeast SUP35 were generated (FIG. 30A). These recombinant proteins were tested for Compound C-induced degradation by Western blot (FIGS. 30B-30D). As the results shown, a 32-amino acid fragment in the C-terminus of human GSPT1 (residues 562-593) is critical for Compound C-induced degradation.

To further map the essential amino acid residues in this 32-amino acid fragment of human GSPT1, various point mutations within the fragment were generated and tested for Compound C-induced degradation of GSPT1 and Compound C-induced interaction between CRBN and GSPT1. FIG. 31A shows the sequence comparison among human GSPT1, human GSPT2, human HBS1L, mouse GSPT1, mouse GSPT2, mouse HBS1L, and yeast SUP35. Among these homologues, only the yeast SUP35 is resistant to Compound C. Sequence alignment suggested that glycine (G) at position 575 of human GSPT1 may contribute to the sensitivity to Compound C. FIG. 31B shows that a G575N mutation in GSPT1 blocked Compound C-induced degradation, but a E576R mutation had no effect. Other mutations, such as I567L, C568H, L569K, R581P. R583A, V585A, and Q589M, exhibited no effect on Compound C-induced degradation of GSPT1 (data not shown). Further, FIG. 31C shows that the G575N mutation in GSPT1 blocked Compound C-induced interaction between CRBN and GSPT1, but the E576R mutation had no effect.

FIGS. 32A-32B demonstrate that the G575N mutation in GSPT1 blocked Compound C-induced growth inhibition and Compound C-induced downstream activation of ATF4 and apoptosis pathways.

6.10.3.3 Crystal Structure of GSPT1-CRBN Complex in the Presence of Compound C

We determined the crystal structure of full length human DDB1 bound to human CRBN (amino acids 40-442), Compound C, and domains 2 and 3 of human GSPT1 (amino acids 437-633) to 3.6 Angstroms resolution. The interaction between purified GSPT1 domains 2 and 3 and purified CRBN-DDB1 complex was not observable in the absence of Compound C, and had a KD of 400 nM in the presence of Compound C, as determined by surface plasmon resonance (data not shown). GSPT1 domain 3 docks against CRBN at the site of Compound C binding, with direct interactions to both Compound C and to the proximal CRBN surface. GSPT1 domain 2 does not directly contact either Compound C or CRBN. This is consistent with biochemical characterization of the interaction between CRBN and GSPT1 by co-immunoprecipitation, which indicated that domain 3 of GSPT1 mediates CRBN interactions (data not shown). CRBN is in a highly similar conformation to the previously described structures, and is bound to DDB1 in a manner consistent with the previously determined structures of CRBN-DDB1. Chamberlain et al., Nature structural & mole. biol. 2014, 21:803-809; Fischer et al., Nature 2014, 512:49-53. Compound C is bound in the tri-Trp pocket of CRBN through its glutarimide ring, with 3 hydrogen bonds to the backbone of W380, H378, and to the side chain of H378 in CRBN (FIGS. 33E and 35A). The isoindolinone ring of Compound C is presented on the surface of CRBN, interacts with both CRBN and GSPT1, and sets up a “hotspot” on CRBN surface (FIG. 35B). The key Glycine (G) residue at position 575 of GSPT1 is engaged. The chemical structure of Compound C is extended compared to the immunomodulatory drugs lenalidomide or pomalidomide (FIGS. 33A-33C), allowing for further interactions with both CRBN and GSPT1. The urea moiety of Compound C is positioned between E377 and H353, with hydrogen bonds to both side chains (FIG. 35C). The species resistance to Compound C is conferred by this region of CRBN. The terminal methyl-chloro-phenyl ring is positioned against the beta sheet core of GSPT1 domain 3 with direct Van der Waals interactions (FIG. 35D).

FIGS. 34A-34C demonstrate excellent agreement between structure and mutational analysis. Point mutations were generated on the surface of CRBN. These mutants were tested in CRBN immunoprecipitation experiment in the presence of vehicle or Compound C. As shown in FIG. 34A, E377V, E377A, and H357A disrupted the binding of GSPT1 to CRBN. H397 partially disrupted the binding. V388I had no effect on the GSPT1-CRBN binding, whereas V388A partially blocked the binding. This indicates that V388 itself is not essential for the interaction between GSPT1 and CRBN, but the substitution (A or I) affects the interaction. Other mutations, such as I371A, R373A, T376A, K406A, and K407A, had no effect on the GSPT1-CRBN binding. FIG. 34B shows the structure of GSPT1-CRBN binding, with mapped SUP35 region in yellow and the key Glycine (G) residue in red. FIG. 34C shows the structure of GSPT1-CRBN binding, with amino acid residues disrupting binding in red, amino acid residues partially disrupting binding in orange, amino acid residues not affecting binding in green, amino acid residues not tested in mutational analysis in blue.

FIG. 36A shows the non-conserved amino acid residues in red between GSPT1 and GSPT2, and FIG. 36A shows the non-conserved amino acid residues in red between GSPT1 and HBS1L. Compound C is shown in green. CRBN is shown in blue. The disparity between GSPT2 and HBS1L in comparison with GSPT1 suggests that the interaction between GSPT2 and CRBN may be very much like that between GSPT1 and CRBN, but that that the interaction between HBS1L and CRBN may be different from that between GSPT1 and CRBN.

FIG. 37 shows backbone-mediated interactions between CRBN and GSPT1 in the presence of Compound C. N351, H357, and W400 are amino acid residues in CRBN. D571, K572, and S574 are amino acid residues in GSPT1. Interactions between CRBN and GSPT1 are indicated by yellow dashed lines. Interactions between amino acid residues within GSPT1 are indicated by black dashed lines.

FIG. 38 shows that the key anchoring motif of GSPT1 is stabilized by internal hydrogen bonds from ASX and ST motifs. The hydrogen bonds between D571 and S574 are indicated by black dashed lines.

The GSPT1 motif which mediates interactions with CRBN-Compound C is a solvent exposed region composed of residues 569 to 578 including a small anti-parallel β-sheet with an a-turn from residues 571-575 (FIG. 41A). Despite the degree of solvent exposure, the turn is well ordered in both the prior GSPT1 crystal structure and in the complex with CRBN. The conformational stability of the turn is likely due to the intramolecular bonding pattern, with an ASX-motif and an ST-turn mediated by D571 and S574, respectively (FIG. 38). These intramolecular motifs might be expected to rigidify and stabilize the conformation of the turn, thereby maintaining a competent conformation prior to cereblon binding (FIG. 41A). This is supported by the immunoprecipitation data, which shows that the D571A and S574A mutants lose CRBN binding (FIG. 41C). The key hydrogen bonds to CRBN are all mediated by backbone carbonyl oxygen atoms, which are displayed in an array at the end of the turn. Carbonyl oxygen atoms from GSPT1 K572, K573, and S574 accept hydrogen bonds from cereblon residues N351, H357, and W400, respectively (FIG. 41A). The fact that key bonds are formed from the backbone of the substrate protein, rather than from side chain residues presents the intriguing possibility that there may be considerable sequence tolerance in substrate recruitment, as long as the backbone remains in the appropriate conformation. The GSPT1 turn lies on top of the isoindolinone ring of Compound C, making hydrophobic and Van der Waals interactions. A key interaction occurs from G575 to the isoindolinone moiety of Compound C. This Glycine residue is of particular importance in determining substrate recruitment, as not only does G575 contribute binding interactions, but also the close sterics at this position indicate that no other residue would be tolerated at this position. This is consistent with the site-direct mutagenesis of the GSPT1 turn, which indicates that G575A loses Compound C dependent CRBN binding (FIG. 41C). Therefore, the key motif that enables substrate recruitment, or the “degron,” is not the linear peptide sequence, but rather the geometric arrangement of 3 backbone hydrogen bond acceptors at the apex of a turn (positions i, i+1, and i+2), with a glycine residue at a key position (i+3). If such a structural degron is shown to be a common factor in recruitment of substrates to drug-bound cereblon, this could present a powerful tool for the identification of new substrate candidates. Other residues within the motif appear to contribute some binding affinity to the complex. For example, V570 exhibits Van der Waals interactions with the methylene-urea linker, and accordingly the V570A mutant displays reduced CRBN binding (FIG. 41C). However, the side chains of the 2 lysine residues K572 and K573 do not affect GSPT1-Compound C-CRBN binding. The amino acid residue E576 is similarly dispensable.

6.10.3.4 Superposition of IKZF1-CRBN Complex Model with GSPT1-CRBN Complex Structure in the Presence of Compound C

FIGS. 39A-39B show the effect of specific amino acid residue mutations on CRBN surface upon substrate binding by immunoprecipitation. FIG. 39A is immunoprecipitation of GSPT1. FIG. 39B is immunoprecipitation of IKZF1. Cereblon and substrate protein were co-expressed in HEK293T cells and co-immunoprecipitated in the presence or absence of lenalidomide, pomalidomide, Compound B or Compound C.

FIGS. 40A-40B map the effect of specific amino acid residue mutations on CRBN surface upon substrate binding. Red indicates amino acid residues whose mutations caused strong reduction in substrate binding. Orange indicates amino acid residues whose mutations caused some reduction in substrate binding. Green indicates amino acid residues whose mutations had no effect on substrate binding. Blue indicates amino acid residues that have not been tested in mutational analysis. FIG. 40A shows the effect on GSPT1 binding. FIG. 40B shows the effect on IKZF1 binding. In particular, E377 appeared to be critical for GSPT1 binding but not for IKZF1 binding.

The similar pattern of sensitivity to mutations on the surface of CRBN between GSPT1 binding and IKZF1 binding (FIGS. 40A-40B) suggests that a similar anchoring motif may be present in IKZF1. A homology model of IKZF1 was constructed based on homologous structures found in the protein data bank. The model of IKZF1 indicates that a zinc finger domain is capable of presenting a turn able to make the 3 key hydrogen bonds with a glycine at the critical position (FIG. 41B). A key glutamine residue on IKZF1, Q146, plays a critical role in cereblon binding. Kronke et al., Science 2014, 343:301-305; Lu et al., Science 2014, 343:305-309. The putative anchoring motif modeled in IKZF1 positions the critical residue, Q146, in a position oriented towards both bound immunomodulatory drug and the CRBN surface. Crucially, there is no sequence homology between IKZF1 and GSPT1 in the anchoring motif regions as modeled, except for the glycine residue at position i+3 (FIG. 41E). The implications of this model were tested by co-immunoprecipitation of CRBN with alanine mutation targeting the putative IKZF1 anchoring motif. A minimal domain of IKZF1 containing only one predicted zinc finger domain is sufficient to pull down CRBN-DDB1 in the presence of pomalidomide (FIG. 41D). However, mutation of the key glycine residue (G151) abrogates this interaction, while mutation of other residues has no effect. Mutation of the putative anchoring motif in IKZF1 reveals that Q146H, as tested by Lu et al. and Kronke et al., is indeed highly deleterious to CRBN binding. In contrast, the Q146A mutation is similar to wild type, suggesting that it is negative consequences of placing a histidine residue at this position, rather than a loss of key interactions from the glutamine that is responsible for the loss of cereblon binding in the Q146H mutants. N148 and Q149 in the proposed anchoring motif do not affect cereblon binding when mutated, in a manner consistent with K572 and K573 in GSPT1, which are predicted to occur at equivalent positions in the complex.

6.10.3.5 Superposition of CK1a-CRBN Complex Model with GSPT1-CRBN Complex Structure in the Presence of Compound C

FIG. 42 shows that CK1a-CRBN complex model superposes with the anchoring motif of GSPT1-CRBN complex. CK1a-CRBN complex model was generated from the closest crystal structure (CK1e). The turn in N-lobe of CK1a aligns well with the turn of GSPT1: the key backbone carbonyls are placed for hydrogen bonds, and the Glycine (G) residue is placed at the key position. This model suggests that CK1a could conceivably bind in a manner consistent with GSPT1, thereby revealing all key elements of the degron. The sequence alignment among GSPT1, IKZF1, and CK1a is shown at the bottom of FIG. 42, with the key Glycine in bold.

6.10.3.6 Specific Amino Acid Residues Determine Compound-Induced Specific Recruitment of Different Substrates of CRBN

A key feature of immunomodulatory drug biology is the striking resistance observed in rodent species. This feature was historically a confounding factor in establishing the efficacy and safety risks associated with thalidomide. It was shown that, in contrast to human cereblon, murine cereblon is unable to rescue immunomodulatory drug sensitivity. Chamberlain et al., Nature structural & mole. biol. 2014, 21:803-809. It was proposed that the molecular basis for this would lie in two variable residues on the cereblon surface proximal to the tri-Tryp pocket, E377V and V388I. The V388I mutation was subsequently shown to mediate mouse resistance to lenalidomide induced CK1a degradation. Kronke et al., Nature 2015, 523:183-188. Despite the potent effect seen on human cells, murine cells are resistant to the antiproliferative and pro-apoptotic effects of Compound C (data not shown). To test the effects of the proximal surface mutations upon substrate degradation, either wild-type (WT) or mutant CRBN were co-transfected with IKZF1 into HEK293T cells, which were treated with Compound C or lenalidomide to examine the effects on substrate degradation. As shown in FIG. 43A, expression of human WT CRBN leads to the degradation of IKZF1 upon treatment with lenalidomide, or to the degradation of both IKZF1 and GSPT1 upon treatment with Compound C. Introduction of the mouse residue E377V blocks the degradation of GSPT1 by Compound C; however, degradation of IKZF1 by either ligand is maintained. In contrast, the mouse mutation V388I blocks the degradation of IKZF1 by both lenalidomide and Compound C, but GSPT1 degradation by Compound C is maintained. FIG. 43B shows that the murine CRBN is unable to mediate degradation of either IKZF1 or GSPT1 regardless of ligand tested. However, substrate degradation can be restored with the human point mutations: V377E restores GSPT1 degradation by Compound C, and I388V restores IKZF1 degradation. The dependence of GSPT1 degradation upon E377 can be rationalized by the crystal structure: the side chain of E377 mediates hydrogen bond interactions with the urea moiety of Compound C. Furthermore, lenalidomide and other immunomodulatory drugs that do not contain the urea moiety are not affected by mutation of E377. This result also suggests that despite an overall similar pattern of substrate dependence on the CRBN surface (FIG. 40), there remain some key differences in CRBN and ligand binding between substrates which may provide opportunities to engineer substrate selectivity.

6.10.4 Discussion

Many efforts are underway aiming to modulate E3 ubiquitin ligase specificity and thereby redirect protein degradation towards novel substrates. PROTACS-type approaches are based around modular small molecules, with discrete moieties that interact with the ubiquitin ligase on one side, and potential substrates on the other, with the 2 functionalities separated by a linker. Winter et al., Science 2015, 348:1376-1381; Deshaies, Nature chem. biol. 2015, 11:634-635. In contrast to PROTACS and related molecules, immunomodulatory drugs are low molecular weight and do not contain discrete, high affinity binders separated by a linker region. It was therefore a question how immunomodulatory molecules are able to scaffold CRBN-substrate interactions with such efficiency. As revealed by the CRBN-DDB1-GSPT1-Compound C structure, Compound C is capable of interacting with both CRBN and GSPT1. However, in contrast to linker based approaches, there is a further effect where Compound C acts by creating an interaction “hotspot” on the CRBN surface for direct interactions with the bound substrate. The contribution from the CRBN surface supports the function of small drug-like molecules without the pharmacokinetic liabilities that might come from ligase modulators incorporating large flexible linkers.

The surface of CRBN also underlies the historically significant phenomena of species sensitivity. Previous safety, efficacy, and mechanistic studies have been severely hampered by the unexplained and dramatic variations in species sensitivity to thalidomide analogues. Considerable progress has been made towards understanding the underlying molecular causes of the variation. It is now clear that rodent resistance can be mediated by 2 surface mutations. Interestingly, these mutations confer resistance to different substrates, with E377V responsible for GSPT1, and V388I mediating CK1a and IKZF1 resistance. This differential effect provides the exciting possibility that there are both common and unique interactions between CRBN, ligand, and substrate, which may be engineered to provide the desired selectivity range.

Many ligases recognize substrates based on linear peptide sequence or features such as post-translational modifications. Such “degrons” establish the substrate degradation sensitivity and therefore define the E3 ligase spectrum. In contrast, CRBN-Compound C recruits GSPT1 through the recognition of a surface turn. Significantly, the interactions are composed of hydrogen bonds from the backbone of GSPT1, which may indicate that the degron in this instance will not be revealed by primary sequence, but instead by the geometry and sterics of a surface turn. A key to the steric compatibility is the presence of a glycine at the precise position within the turn. This glycine residue packs up tightly against the isoindolinone of Compound C, and conformational changes in the protein would be necessary to accommodate any other residue in this complex.

Our modeling and mutational work on IKZF1 raises the possibility of a common structural degron, and it may become possible to identify candidate substrates by searching for such a CRBN response element across the proteome. Such candidate substrates may then form the targets for exploitation by the next generation of CRBN modulators. 

What is claimed is:
 1. A method of identifying a CRBN-associated protein (CAP), or identifying a target of a compound, comprising: (I) (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay; and (c) identifying the protein as a CAP if the protein specifically binds to CRBN in the CRBN-binding assay; or (II) (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay; and (c) identifying the protein as a CAP if the protein level decreases in the CRBN-mediated degradation assay; or (III) (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-binding assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein specifically binds to CRBN in the CRBN-binding assay; or (IV) (a) searching a protein database for a protein comprising an amino acid sequence of a degron in a CAP; (b) testing the protein in a CRBN-mediated degradation assay in the presence of the compound; and (c) identifying the protein as the target of the compound if the protein level decreases in the CRBN-mediated degradation assay; and wherein the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11), CXXCG (SEQ ID NO:16), or NXXNG (SEQ ID NO:17), wherein X can be any amino acid residue.
 2. The method of claim 1, wherein the CAP is a substrate of CRBN.
 3. The method of claim 1, wherein the amino acid sequence of the degron is [D/N]XX[S/T]G (SEQ ID NO:11), wherein X can be any amino acid residue.
 4. The method of claim 1, wherein the amino acid sequence of the degron is CXXCG (SEQ ID NO:16) or NXXNG (SEQ ID NO:17), wherein X can be any amino acid residue.
 5. The method of claim 1, wherein the CRBN-binding assay is performed in the presence of a compound.
 6. The method of claim 5, wherein the compound is a cereblon modifying agent (CMA).
 7. The method of claim 5, wherein the compound is an immunomodulatory compound.
 8. The method of claim 5, wherein the compound is selected from the group consisting of thalidomide, lenalidomide, pomalidomide, Compound A (3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione), Compound B (3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione), Compound C (1-(3-chloro-4-methylphenyl)-3-42-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea), Compound D (2-(4-chlorophenyl)-N-42-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide), and Compound E (2-(4-flurophenyl)-N-42-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide). 